CN203700242U - Device for collecting animal parotid saliva - Google Patents

Abstract

The utility model discloses a device for collecting parotid saliva of animals, which comprises a collection bag, a collection tube communicating with the inside of the collection bag and a release plug arranged at the bottom of the collection bag, and a fistula is connected with the top of the collection tube, and the fistula includes two The infusion tubes are arranged side by side, the upper part of the two infusion tubes is forked, and the lower part is closely connected. The device for collecting animal parotid gland saliva is respectively inserted into the animal parotid duct near the oral cavity end and the parotid gland end through the two side-by-side infusion tubes on the fistula connected to the collection tube, the saliva enters the collection bag through the infusion tube near the parotid gland end, and opens the bottom of the collection bag The release plug can take out the parotid saliva in the collection bag at one time. This collection device can collect the parotid saliva without pollution for a long time and isolated from the outside world. This utility model is used in the technical field of bioengineering.

Description

A device for collecting animal parotid saliva

technical field

The utility model relates to the technical field of bioengineering, in particular to a device for collecting animal parotid saliva.

Background technique

With the development of transgenic technology, the use of transgenic animals to produce pharmaceutical proteins, especially in the mammary glands of transgenic animals is the most successful, but there are also shortcomings. For example, only female animals can express pharmaceutical proteins in mammary glands, and milk production can only be carried out in a certain season or time. These shortcomings hinder the development of mammary gland bioreactors.

At present, the technology of expressing foreign proteins in the parotid glands of domestic animals has also been successful using parotid gland-specific promoters. Compared with mammary gland bioreactors, parotid gland bioreactors have many advantages: 1. There is no gender difference; 2. No time Differences; 3. Animals do not need to wait until sexual maturity to mate and produce milk to collect purified protein, which shortens the time to obtain recombinant protein; 4. There are few protein components in parotid saliva, and recombinant protein is easy to separate and purify.

To purify recombinant proteins from parotid saliva, there must be a method for long-term and stable collection of large quantities of non-contaminated parotid saliva. Among the current saliva collection methods, only fistula surgery can meet this demand, but so far there is no convenient and effective collection device.

The existing methods for collecting animal saliva mainly include: one is to anesthetize the animal, inject pilocarpine, induce the animal to secrete saliva, and then directly suck the saliva from the opening of the parotid gland. This method needs to anesthetize and fix the animal every time the saliva is collected, which is time-consuming It is laborious, and the amount of saliva collected is unstable and easily contaminated by other substances in the mouth; the other is to put cotton cloth or cotton rope into the animal's mouth, let it chew for a period of time, squeeze the saliva on the cotton cloth or cotton rope or The saliva collected by this method is mixed saliva, and the amount collected is very small; there is also a fistula operation method, which separates the parotid duct from the front of the masseter muscle and the mandible, and inserts the duct towards the parotid gland. The parotid gland saliva is drained out. This method can collect a large amount of non-polluted parotid gland saliva, but it is difficult to nurse during the collection period, and it is easy to cause the fistula to be pulled out, and saliva is wasted when the saliva is not collected.

Utility model content

In order to solve the above problems, the utility model provides a device that can collect a large amount of animal parotid saliva for a long time without pollution.

The technical scheme that the utility model solves its technical problem adopts is:

A device for collecting parotid saliva of animals, comprising a collection bag, a collection tube connected to the inside of the collection bag, and a release plug arranged at the bottom of the collection bag, and a fistula is connected to the top of the collection tube, and the fistula includes two parallel infusion tubes , the upper part of the two infusion tubes is forked, and the lower part is closely connected.

As a further improvement of the technical solution of the utility model, grooves surrounding the infusion tubes are provided at the bottoms of the bifurcated parts of the two infusion tubes.

As a further improvement of the technical solution of the utility model, the inner diameters of the two infusion tubes along the length direction are consistent, and the outer diameters of the two infusion tubes gradually increase from the inlet end to the connecting part of the two infusion tubes.

As a further improvement of the technical solution of the utility model, the outer diameter of the connecting part of the two infusion tubes on the fistula is the same, and the inner diameter of the fistula gradually increases from the bifurcation of the two infusion tubes to the bottom end.

As a further improvement of the technical solution of the utility model, a ring of protrusions with an undercut portion is provided on the periphery of the top end of the collecting tube, and the protrusions are embedded in the fistula for airtight connection.

As a further improvement of the technical solution of the utility model, there is also a fistula joint that can be installed at the bottom of the fistula, and the two sides of the bottom of the fistula joint are connected.

As a further improvement of the technical solution of the utility model, a handle is provided on the collection bag.

Beneficial effects of the utility model: the device for collecting animal parotid saliva is respectively inserted into the end near the oral cavity and the end near the parotid gland of the animal parotid duct through two parallel infusion tubes on the fistula connected to the collection tube, and the saliva enters and collects through the infusion tube near the parotid gland end. In the bag, open the release plug at the bottom of the collection bag to take out the parotid saliva in the collection bag at one time. This collection device can collect the parotid saliva for a long time without pollution from the outside world.

Description of drawings

Below in conjunction with accompanying drawing, the utility model is further described:

Fig. 1 is a schematic diagram of the overall structure of the utility model embodiment;

Fig. 2 is a schematic diagram of the cooperative structure of the fistula and the joint of the fistula in the embodiment of the utility model;

Fig. 3 is a schematic diagram of the connection structure at the top of the collection pipe of the present invention.

Detailed ways

Referring to Figures 1 to 3, the utility model is a device for collecting animal parotid saliva, including a collection bag 1, a collection tube 2 communicating with the inside of the collection bag 1, and a release plug 3 arranged at the bottom of the collection bag 1, which is connected to the collection bag 1. The top of the tube 2 is connected with a fistula 4. The fistula 4 includes two parallel infusion tubes. The upper part of the two infusion tubes is forked and the lower part is closely connected.

This device for collecting animal parotid gland saliva is respectively inserted into the near oral cavity end and the near parotid gland end of the animal parotid gland duct through two transfusion tubes on the fistula 4 connected to the collection tube 2, and the saliva enters the collection bag 1 through the transfusion tube near the parotid gland end, and opens The release plug 3 at the bottom of the collection bag 1 can take out the parotid saliva in the collection bag at one time, and the collection device can collect the parotid saliva for a long time without pollution from the outside world.

As a preferred embodiment of the present invention, grooves 41 surrounding the infusion tubes are provided at the bottoms of the bifurcated parts of the two infusion tubes.

After the two infusion tubes are connected with the parotid gland duct in the animal body, the infusion tube can be fastened and fixed at the groove 41 position to prevent the fistula 4 from being pulled out.

As a preferred embodiment of the present invention, the inner diameters of the two infusion tubes along the length direction are the same, and the outer diameters of the two infusion tubes gradually increase from the inlet end to the connecting part of the two infusion tubes.

As a preferred embodiment of the present invention, the outer diameters of the connecting parts of the two infusion tubes on the fistula 4 are the same, and the inner diameter of the fistula 4 gradually increases from the bifurcation of the two infusion tubes to the bottom end.

As a preferred embodiment of the present invention, a ring of protrusions 22 with an undercut portion 21 is provided on the periphery of the top end of the collecting tube 2 , and the protrusions 22 are embedded in the fistula 4 for airtight connection.

As a preferred embodiment of the present invention, there is also a fistula connector 5 that can be installed on the bottom of the fistula 4 , and the two sides of the bottom of the fistula connector 5 communicate.

When it is not necessary to collect parotid gland saliva through the collection bag 1, the fistula 4 can be separated from the collection tube 2, and the fistula joint 5 can be inserted at the tail end of the fistula 4, so that the infusion tubes on both sides of the fistula 4 can form backflow, so that the saliva secreted by the animal It can also flow back to the oral cavity, avoiding waste when the saliva is not collected.

As a preferred embodiment of the present invention, the collection bag 1 is provided with a handle 6 .

The collection bag 1 is provided with a handle 6, the collection bag 1 can be hung on the animal, so that the animal can walk freely, or the collection bag 1 is hung on the column when the animal is restricted to walk freely, and the collection bag 1 has a capacity scale. The volume of collected saliva can be measured. There is an outlet at the bottom of the collection bag 1. When collecting saliva, the outlet is covered. When the saliva is collected, the outlet is opened, and the saliva can be transferred to other collection bottles that can be preserved for a long time.

Of course, the present invention is not limited to the above-mentioned embodiments. Those skilled in the art can also make equivalent modifications or replacements without violating the spirit of the present utility model. These equivalent modifications or replacements are all included in the claims of this application. within the limited range.

Claims (7)

1. collect the device of animal parotid sputum for one kind, it is characterized in that: the collection tube (2) that comprise collecting bag (1), communicates with described collecting bag (1) inside and be arranged at the release plug mouth (3) of described collecting bag (1) bottom, be connected and be provided with fistula (4) with the top of described collection tube (2), described fistula (4) comprises the tubing that twice are arranged side by side, and described in two, tubing top bifurcated, bottom are close to connected.

2. the device of collection animal parotid sputum according to claim 1, is characterized in that: described in two, the bottom of tubing upper bifurcation part is equipped with the groove (41) around tubing.

3. the device of collection animal parotid sputum according to claim 1 and 2, is characterized in that: described in two, internal diameter is consistent along its length for tubing, and described in two, the external diameter of tubing increases gradually from the connecting portion of inlet end to two tubing.

4. the device of collection animal parotid sputum according to claim 1 and 2, is characterized in that: the connected position of upper two tubings of described fistula (4) external diameter is in the same size, and described fistula (4) is upper to be increased gradually from two tubing bifurcation to bottom internal diameters.

5. the device of collection animal parotid sputum according to claim 1 and 2, it is characterized in that: outside the top of described collection tube (2), be arranged with the projection (22) that a circle has back-off part (21), described projection (22) embeds in fistula (4) carries out airtight connection.

6. the device of collection animal parotid sputum according to claim 5, is characterized in that: be also provided with the fistula joint (5) that can be installed on described fistula (4) bottom, the both sides of described fistula joint (5) bottom communicate.

7. the device of collection animal parotid sputum according to claim 1 and 2, is characterized in that: described collecting bag (1) is provided with handle (6).