CN202814866U - Color difference assessment system for biochemical analyzer - Google Patents

Abstract

The utility model relates to a color difference evaluation system for a biochemical analyzer. The system takes the color image of the biochemical sample test paper through the color digital system and inputs it into the computer, obtains the standard threshold color in the sample analysis item through the standard threshold acquisition unit, and converts the RGB value of the standard threshold color into the chromaticity of the standard threshold value; set up the RGB color space of the standard threshold value acquisition unit by the calibration unit, and convert the RGB color space and CIEXYZ space to each other; convert the RGB value of the sample color obtained by the chromaticity value acquisition unit into a chromaticity value; The chromaticity value is displayed through the display unit; use the chromaticity value of the sample and the chromaticity value of the standard threshold to calculate the color difference and obtain a set of color difference values, select the minimum color difference value in the set of color difference values, and pass the color difference The evaluation unit completes the color difference evaluation of biochemical analysis.

Description

The aberration assessment system that is used for Biochemical Analyzer

Technical field: the utility model belongs to aberration evaluation field, the aberration assessment system that particularly carries out medico's fractional analysis with the color aberration.

Background technology: along with the raising of people's living standard, health more and more is subject to special attention.People note health care more, check at any time, and it is dynamic to grasp health and the state of an illness.Thereby, easy to operate, can popularize the favor that also more and more is subject to people in detection means family, that can realize complete monitoring and analysis.

Medico's fractional analysis is the important inspection diagnostic means of hospital clinical, and the urine sample biochemical analysis has become clinical the most widely inspection item, 10 remainders of carrying out the urine sample biochemical analysis detect, and what essence embodied all is that urine and urine test paper react the afterwards change color of each.According to the color that presents, determine normal or undesired, and under undesired+number quantity, the i.e. order of severity of the state of an illness.Biochemical Analyzer kind in the past is a lot, but its limitation is respectively arranged.Along with the arrival of digital times, color image processing device such as color digital camera and color scanner, is widely used.

Summary of the invention: for solve in the past urine and test paper reaction after utilize human eye to differentiate to cause to have too much subjective factor or hospital to utilize reflectivity size some characteristic wavelength (such as 550nm, 620nm, 720nm etc.) under quantitatively to detect to cause and detect and the problem of inconvenience, the purpose of this invention is to provide and a kind ofly can quantitatively accurately judge state of an illness rank, no matter be hospital, or the individual all can realize conveniently, the cheap and aberration assessment system of the Biochemical Analyzer of urinalysis accurately.This aberration assessment system also can be used for other medico fractional analysis relevant with color.

Aberration assessment system for Biochemical Analyzer of the present invention, described Biochemical Analyzer comprises: reaction tray, be used for carrying a plurality of reaction cup, described reaction cup is the cuvette of carrying biochemical samples to be measured, this reaction tray is by the reaction tray drive unit drives; The test paper feed unit is used for providing the test paper that reacts with biochemical samples; Control module is used for analysis and Control reaction tray driver element and test paper feed unit; Image acquisition unit is used for obtaining the reacted test paper image of biochemical samples; It is characterized in that: described aberration assessment system comprises the level threshold value acquiring unit, is used for obtaining the level threshold value color at the biochemical samples analysis project, and this level threshold value color rgb value is converted to the chromatic value of level threshold value; Image storage unit is used for storing above-mentioned image; Calibrate the unit, be used for setting up the RGB color space of described level threshold value acquiring unit, and this RGB color space and CIEXYZ space are changed mutually; The aberration evaluation unit, utilize described image, the rgb value of the biochemical samples color that obtains is converted to the chromatic value of biochemical samples, utilize the chromatic value of biochemical samples and the chromatic value of level threshold value to carry out Colorimetry and obtain one group of value of chromatism, choose the minimum value of chromatism in this group value of chromatism, obtain the data result that biochemical samples checks, determine the check result of biochemical samples according to these data, finish the aberration evaluation of biochemical analysis.

Preferably, described biochemical samples is urine sample.

Technical scheme by the invention described above.Aberration assessment system of the present invention passes through the colored digital system calibration, can solve accurately, compactly the colored digital system by different brands, perhaps the problem that same color can collect different color tristimulus values (rgb value) is absorbed by the color digital camera system of same brand different batches.Aberration assessment system of the present invention also utilizes the evaluation method of color distinction in the colorimetry, can accurately draw the aberration of urine sample chromatic value and threshold value chromatic value, and then can judge more accurately the order of severity of the state of an illness, be that the present invention utilizes the colored digital system that steps into huge numbers of families, make the medical science Biochemical Analyzer enter into a new field, solved the limitation of background technology medical science Biochemical Analyzer, avoided the human factor of measuring, be not only and make detection more accurate, the more important thing is to make to detect to become more simple, convenient.

Description of drawings:

Fig. 1 is the structural representation for Biochemical Analyzer of the present invention

Embodiment:

The present invention is further described in conjunction with the accompanying drawings and embodiments as an example of urine sample example for the below, but the embodiment of aberration assessment system urine analysis of the present invention, it can also be widely used in the biochemical samples check relevant with the color aberration outside the urine analysis.

Be used for the aberration assessment system structure of Biochemical Analyzer referring to Fig. 1, described Biochemical Analyzer comprises: reaction tray 1 is used for carrying a plurality of reaction cup 2, and described reaction cup is the cuvette of carrying biochemical samples to be measured, and this reaction tray 1 is driven by reaction tray driver element 3; Test paper feed unit 4 is used for providing the test paper that reacts with biochemical samples; Control module 5 is used for analysis and Control reaction tray driver element 3 and test paper feed unit 4; Image acquisition unit 6 is used for obtaining the reacted test paper image of biochemical samples; It is characterized in that: described aberration assessment system 7 comprises: level threshold value acquiring unit 8 is used for obtaining the level threshold value color at the biochemical samples analysis project, and this level threshold value color rgb value is converted to the chromatic value of level threshold value; Image storage unit 9 is used for storing above-mentioned image; Calibrate unit 10, be used for setting up the RGB color space of described level threshold value acquiring unit, and this RGB color space and CIEXYZ space are changed mutually; Aberration evaluation unit 11, utilize described image, the rgb value of the biochemical samples color that obtains is converted to the chromatic value of biochemical samples, utilize the chromatic value of biochemical samples and the chromatic value of level threshold value to carry out Colorimetry and obtain one group of value of chromatism, choose the minimum value of chromatism in this group value of chromatism, obtain the data result that biochemical samples checks, determine the check result of biochemical samples according to these data, finish the aberration evaluation of biochemical analysis.

According to the requirement of aberration evaluation, use above-mentioned assessment system calibration after, realize utilizing aberration to carry out the purpose of medico's fractional analysis.Namely at first utilize the colored digital system that the level threshold value color in the sample analysis project is taken, obtain level threshold value color tristimulus values (rgb value), and convert the chromatic value of level threshold value to.Convert the tristimulus values (rgb value) of the urine sample that obtains the chromatic value of corresponding urine sample to, and carry out Colorimetry with the chromatic value of level threshold value, can judge the degree of the state of an illness.

The colored digital system can adopt color digital camera or camera.Standard illuminants can adopt standard illuminants A and standard illuminants D65.

1, the aberration assessment system for Biochemical Analyzer of the present invention, the acquisition of its level threshold value and color space conversion are achieved in that

1) acquisition of level threshold value: utilize color digital camera under CIE standard working flare A, the level threshold value color in the urine analysis project to be taken.The threshold value color tristimulus values (rgb value) of taking acquisition is converted to the chromatic value of corresponding color space.

When for example measuring urobilinogen: the color tristimulus values of the urobilinogen level threshold value point under the standard illuminants A (XYZ value), tristimulus values (Lab value), the chromaticity coordinate value (x, y value) of color that thus chromatic value of level threshold value is converted into the even color space is as shown in the table.

By this table as seen, the chromatism data between the level threshold value critical point is considerably beyond the threshold value of human eye resolution color distinction.

2) color space conversion: adopt look-up table, polynomial regression method, neural network etc., finish the color space conversion.If only 50 or 60 in the color that relates to, linear transformation can meet the demands.

X＝a11R+a12G+a13B

Y＝a2IR+a22G+a23B

Z＝a31R+a32G+a33B

For the urobilinogen test-based examination, matrix of coefficients is:

0.1167 0.3234 -0.0783

0.0480 0.3736 -0.0061

-0.0228 0.0510 0.5578

2, the aberration assessment system for Biochemical Analyzer of the present invention, its aberration evaluation is achieved in that

According to the even color space tristimulus values (L1a1b1) of the level threshold value color of test item tinctorial pattern and the even color space tristimulus values (L2a2b2) of urine sample color to be measured, just can utilize following formula to calculate aberration between the two.

$\mathrm{\&Delta;E}=\sqrt{{({\mathrm{<figure-callout\; id="2"\; label="L"\; filenames="DEST\_PATH\_HSB00001006805400011.png"\; state="\{\{state\}\}">L</figure-callout>}}_2^{*}-L_1^{*})}^2+{(a_2^{*}-a_1^{*})}^2+{(b_2^{*}-b_1^{*})}^2}$

Press the minimum result who determines this item inspection of aberration, namely normal, accurate normal ,+number, ++ number, +++number etc.

Embodiment 2

The main element of Biochemical Analyzer is identical with embodiment 1, does not repeat them here, and is with the difference of embodiment 1:

The acquisition of level threshold value realizes like this:

Utilize camera under the standard illuminants D65 of International Commission on Illumination (ClE), the level threshold value color in the urine analysis project to be taken.The threshold value color tristimulus values (rgb value) of taking acquisition is converted to the chromatic value of corresponding color space.When for example measuring protein: the color tristimulus values of the protein level threshold value point under the standard illuminants D65 (XYZ value), and it is as shown in the table thus the chromatic value of level threshold value to be converted into tristimulus values (Lab value), the chromaticity coordinate value (x, y value) of color of the even color space:

Claims (2)

1. A color difference evaluation system for a biochemical analyzer, said biochemical analyzer comprising: a reaction tray for carrying a plurality of cuvettes, said cuvettes are cuvettes carrying biochemical samples to be measured, the reaction The disk is driven by the reaction disk drive unit; the test paper supply unit is used to provide the test paper reacted with the biochemical sample; the control unit is used to analyze and control the reaction disk drive unit and the test paper supply unit; the image acquisition unit is used to obtain the reaction of the biochemical sample The final test paper image; it is characterized in that: the color difference evaluation system includes a standard threshold acquisition unit, which is used to obtain the standard threshold color in the biochemical sample analysis project, and convert the standard threshold color RGB value into the chromaticity of the standard threshold Value; Image storage unit, for storing above-mentioned image; Calibration unit, for setting up the RGB color space of described standard threshold acquisition unit, and this RGB color space and CIEXYZ space mutual conversion; Color difference evaluation unit, utilize described image , convert the obtained RGB value of the color of the biochemical sample into the chromaticity value of the biochemical sample, use the chromaticity value of the biochemical sample and the chromaticity value of the standard threshold to calculate the color difference and obtain a set of color difference values, select this set The minimum color difference value in the color difference value is used to obtain the data result of the biochemical sample inspection, and the inspection result of the biochemical sample is determined according to the data, and the color difference evaluation of the biochemical analysis is completed. 2. The color difference evaluation system according to claim 1, wherein the biochemical sample is a urine sample. the

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