CN201917521U - Confocal fluorescent detection device and immunity bedside detector adopting same - Google Patents
Confocal fluorescent detection device and immunity bedside detector adopting same Download PDFInfo
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- CN201917521U CN201917521U CN201020664739XU CN201020664739U CN201917521U CN 201917521 U CN201917521 U CN 201917521U CN 201020664739X U CN201020664739X U CN 201020664739XU CN 201020664739 U CN201020664739 U CN 201020664739U CN 201917521 U CN201917521 U CN 201917521U
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Abstract
The utility model provides a confocal fluorescent detection device and an immunity bedside detector adopting the same. The confocal fluorescent detection device mainly comprises a beam splitter, an excitation light source, a microobjective, a chip micro-channel, and a detector, wherein the beam splitter can reflect excitation light and transmit fluorescent light; the excitation light source has a transmitting direction facing to the beam splitter; the microobjective is arranged in the reflection direction of the beam splitter; the chip micro-channel is arranged on one side of the microobjective and has fluorescent substances distributed thereon; and the detector is arranged in the transmission direction of the beam splitter. The immunity bedside detector mainly comprises a casing, and the confocal fluorescent detection device, a scanning device, a circuit processing module, and a communication module which are arranged in the casing, wherein a socket is arranged on the casing; the confocal fluorescent detection device, the scanning device, and the communication module are all connected with the circuit processing module; and the scanning device adopts an immunochromatography test strip or a microfluidic chip transmission scanning device arranged at the socket. By adopting the utility model, the result quantification of both fluorescent immunochromatography and microfluidic chip agent detection is realized.
Description
Technical field
The utility model relates to a kind of clinical examination equipment of technical field of medical instruments, particularly relates to a kind of myocardium mark (as myocardium fatty acid binding protein H-FABP, myocardium calcium protein cTnI, isoenzymes of creatine kinase CK-MB, myoglobins Myoglobin), Type B natriuretic peptide BNP of being used for) an a kind of confocal fluorescent pick-up unit that special-purpose quantitative bed side is detected and an immunity other detector of using this device.
Background technology
Cardiovascular medicine is one of the swiftest and the most violent subject of 21st century medical development, and preventive medicine, evidence-based medicine EBM and interventional therapeutic technique have all been obtained the achievement that attracts people's attention, and people bring in constant renewal in for the treatment idea and the means of angiocardiopathy.We have realized that have only to cardiovascular patient carry out morning prevention, early find, treatment early, could at utmost prevent to disable, lethal effect, at utmost improve patient's prognosis and quality of life.
Cardiovascular check is " bottleneck " subject in the whole cardiovascular field, because only correctly diagnose the illness in the short as far as possible time, could be timely and effectively advanced person's treatment means is used for clinical, and the patient is benefited.
Since 2000, having begun to list in an other real-time test in the U.S. AACC meeting--POCT (Point Of Care Testing) content, European MEDICA in 2006 has also increased technical report and the on-the-spot demonstration report of POCT.POCT becomes the highest product of rate of growth in global medicine equipment and the medical diagnosis industry.Wherein, heart disease check in real time becomes part with fastest developing speed in all POCT detections.
But, the other detecting instrument of existing bed is employed, be single fluorescence immunoassay reagent, comprise fluorescence immune chromatography and fluorescence immunoassay micro-fluidic chip, it can only carry out the sxemiquantitative diagnosis, and testing result interpretation subjectivity is big, the result should not preserve, therefore in structure and use, obviously still have inconvenience and defective, and demand urgently further being improved.How to found a kind of confocal fluorescent pick-up unit of the new structure of realizing fluorescence immune chromatography and micro-fluidic chip reagent testing result quantification and use the other detector of immunity bed of this device, the real important improvement target that belongs to current this area.
The utility model content
The technical problems to be solved in the utility model provides a kind of confocal fluorescent pick-up unit and uses the other detector of immunity bed of this device, make it can realize fluorescence immune chromatography and micro-fluidic chip reagent testing result quantification, thereby overcome the deficiency of the other detector of existing fluorescence immunoassay bed.
For solving the problems of the technologies described above, a kind of confocal fluorescent pick-up unit of the utility model mainly comprises: the spectroscope that can reflect exciting light and transmission fluorescence; Transmit direction is towards spectroscopical excitation source; Be arranged on the microcobjective on the spectroscope reflection direction; Be positioned at the microcobjective opposite side and be furnished with the chip microchannel of fluorescent material; And be arranged on detecting device on the spectroscope transmission direction.
As a kind of improvement of the present utility model, described chip microchannel is positioned at the focus place of microcobjective.
Also be provided with emission light optical filter between described excitation source and the spectroscope.
Also be provided with the exciting light optical filter between described spectroscope and the detecting device.
Described exciting light optical filter is a bandpass filter.
In addition, the utility model also provides a kind of other detector of immunity bed of using said apparatus, mainly comprise casing, and be installed in confocal fluorescent pick-up unit, scanister, processing of circuit module and communication module in the casing, wherein: casing is provided with socket; Confocal fluorescent pick-up unit, scanister and communication module all are connected with the processing of circuit module; Scanister is immuno-chromatographic test paper strip or micro-fluidic chip transmission scanister, is arranged on spigot.
As further improvement, described confocal fluorescent pick-up unit is connected with the processing of circuit module by optical signal amplifying large compensation module.
Described communication module is a bluetooth module.
Described processing of circuit module also is connected with memory module.
Described processing of circuit module also is connected with display module.
After adopting such structure, the utility model is complied with cardiovascular diagnosis and treatment technology rapid development, cooperate fluorescence immunoassay reagent, comprise fluorescence immune chromatography and fluorescence immunoassay micro-fluidic chip, can in 15 minutes, measure the blood of human body sample, comprise whole blood, myocardium mark in serum and the blood plasma, realized the quantification of fluorescence immunoassay diagnostic reagent is detected, measurement result is direct, accurately, be clinical rescue, treatment, more the back is observed provides foundation, become the POCT system that medical institutions' diagnosis monitor patients is used with realistic meaning, and compact integral structure, clean environment firendly, operate simple and easy, need not debug during use, thereby have good market outlook and economic benefit.
Description of drawings
Above-mentioned only is the general introduction of technical solutions of the utility model, and for can clearer understanding technological means of the present utility model, the utility model is described in further detail below in conjunction with accompanying drawing and embodiment.
Fig. 1 is the structural representation of a kind of confocal fluorescent pick-up unit of the utility model.
Fig. 2 is a kind of external structure synoptic diagram of using the other detector of immunity bed of confocal fluorescent pick-up unit of the utility model.
Fig. 3 is that a kind of module of using the other detector of immunity bed of confocal fluorescent pick-up unit of the utility model is formed synoptic diagram.
Embodiment
See also shown in Figure 1ly, a kind of confocal fluorescent pick-up unit of the utility model mainly comprises spectroscope 1, excitation source 2, microcobjective 3, chip microchannel 4 and detecting device 5.
Wherein, spectroscope 1 can reflect exciting light and transmission fluorescence, its role is to make the emission light of excitation source 2 to be reflected and can not see through, and the fluorescence of longer wavelength then can major part see through, thereby eliminates the interference of strong exciting light to fluoroscopic examination effectively.
The transmit direction of excitation source 2 is towards spectroscope 1.
Be distributed with fluorescent material in the chip microchannel 4, be divided into the both sides of microcobjective 3 with spectroscope 1.Preferable, chip microchannel 4 is arranged on the focus place of microcobjective 3.
Detecting device 5 is arranged on the transmission direction of spectroscope 1.
In addition, emission light optical filter 6 also can be set between excitation source 2 and spectroscope 1, and between spectroscope 1 and detecting device 5, be provided with exciting light optical filter 7.Exciting light optical filter 7 is preferably bandpass filter, and only the fluorescence for specific band sees through, to reduce the ground unrest of detecting device.
Be the basic light path of the utility model confocal fluorescent pick-up unit shown in Fig. 1 arrow: the exciting light that sends from excitation source 2 is after 6 filtering of emission light optical filter, reflected by dichroic beam splitter 1, focus in the chip microchannel 4 by microcobjective 3 again, send the fluorescence of respective wavelength to excite fluorescent material in the microchannel 4; Fluorescence is collected by same object lens 3, see through dichroic beam splitter 1 after, by exciting light optical filter 7 elimination parasitic lights, enter detecting device 5 at last and be converted into electric signal.Because the focusing of exciting light and the collection of fluorescence are all finished by same microcobjective 3, and exciting light focal beam spot and diaphragm be in respectively on two conjugate focuses, so be referred to as common focus type detecting device.
See also Fig. 2, shown in Figure 3, a kind of other detector of immunity bed of using above-mentioned confocal fluorescent pick-up unit of the utility model, mainly comprise: casing 9, be installed in the processing of circuit module in the casing 9, the scanister that is connected with the processing of circuit module, communication module, display module, memory module, optical signal amplifying large compensation module, and the confocal fluorescent pick-up unit that is connected with optical signal amplifying large compensation module.
Wherein, casing 9 is provided with immunochromatography reagent and micro-fluidic chip socket 91.
The processing of circuit module is the procedure stores and the performance element of detector, by programmed control confocal fluorescent pick-up unit, optical signal amplifying large compensation module, scanister, communication module, display module detects and data storage, adopt the concentration relationship of foundation of T line (detection line) and C line (nature controlling line) signal ratio and detected sample, set up mathematical model with its rule, incorporate embedded from demarcating and self check software, can compensate automatically many interference signals when making test, improve the sensitivity and the accuracy of instrument.
The confocal fluorescent pick-up unit can reduce bias light to be disturbed, particularly reduce exciting light to detecting the influence of light path, realize detecting with fluorescence immune chromatography reagent strip and fluorescence micro-fluidic chip the detection by quantitative of immune substance, this is the key point that realizes the high sensitivity fluoroscopic examination.
Scanister is immuno-chromatographic test paper strip or micro-fluidic chip transmission scanister, is arranged on socket 91 places, can make the confocal fluorescent module find the scanning area of photoluminescence peak accurately.
Optical signal amplifying large compensation module is to the optical signal amplifying large compensation, and interference source added up reject and analyze, and eliminates background interference.
Communication module is preferably bluetooth module, realize that by PC and software fluorescence immune chromatography reagent strip and fluorescence micro-fluidic chip criticize a calibration curve and measure the communication setting of technical parameters such as number of times, avoided fault by IC-card is stored and transmission may bring, guarantee the accuracy of use and testing result, reduced cost simultaneously.In addition, the setting of communication module also can utilize functions such as installed software realization telecommunication, case storage, printing as a result, networking, compatible hospital information system on external PC.
In addition, the utility model also can utilize the standard fluorescence card of outfit, and instrument is returned to zero and the standard value demarcation, calibrates at any time and self check, has strengthened the Quality Control ability.
Because many immune substances content in patient's blood sample is lower, but must detect, and the detection zone of fluorescence immune chromatography reagent and micro-fluidic chip only be the fine rule of about 1mm that detection time signal is extremely faint.Traditional fluorescence detection optical path adopts orthogonal design, and the difficult interference of eliminating bias light can cause certain error to testing result, therefore only is applicable to the conventional sense that the sample cell volume is bigger.Utilize fluorescence immune chromatography test paper and the fluorescence micro-fluidic chip that the utility model discloses a kind of special use carry out the other detector of hand-held bed of the quantitative fast detecting of fluorescence immunoassay, utilize confocal fluorescent pick-up unit and scanister, improved resolution T line in fluorescence immune chromatography test paper bar or the micro-fluidic chip and C line; Adopt confocal fluorescent light path design technology, and the light signal that produces during to scanning amplifies, compensates, make scalable dozens or even hundreds of times of photoelectricity inverted signal, thereby the detection sensitivity of making and precision are higher, effectively raise the accuracy of detection.
Detection sensitivity with myocardium mark is an example, and the utility model can reach:
H-FABP H-FABP---0.6ng/ml,
Myocardium calcium protein cTnI---0.2ng/ml,
Isoenzymes of creatine kinase CK-MB---1.0ng/ml,
Myoglobins Myoglobin---5ng/ml;
The detection sensitivity of heart failure mark can reach:
Type B natriuretic peptide BNP---5pg/ml.
As mentioned above, the sensitivity of the other detector of the utility model immunity bed is apparently higher than domestic existing product, and the key technical indexes has also reached international like product advanced level, and product structure is simple, meets cost benefit, is more suitable for extensive popularization.
The above; it only is preferred embodiment of the present utility model; be not that the utility model is done any pro forma restriction, those skilled in the art utilize the technology contents of above-mentioned announcement to make a little simple modification, equivalent variations or modification, all drop in the protection domain of the present utility model.
Claims (10)
1. confocal fluorescent pick-up unit is characterized in that mainly comprising:
Can reflect the spectroscope of exciting light and transmission fluorescence;
Transmit direction is towards spectroscopical excitation source;
Be arranged on the microcobjective on the spectroscope reflection direction;
Be positioned at the microcobjective opposite side and be furnished with the chip microchannel of fluorescent material; And
Be arranged on the detecting device on the spectroscope transmission direction.
2. confocal fluorescent pick-up unit according to claim 1 is characterized in that described chip microchannel is positioned at the focus place of microcobjective.
3. confocal fluorescent pick-up unit according to claim 2 is characterized in that also being provided with between described excitation source and the spectroscope emission light optical filter.
4. confocal fluorescent pick-up unit according to claim 2 is characterized in that also being provided with between described spectroscope and the detecting device exciting light optical filter.
5. confocal fluorescent pick-up unit according to claim 4 is characterized in that described exciting light optical filter is a bandpass filter.
6. an application rights requires the other detector of immunity bed of each described device among the 1-5, and it is characterized in that mainly comprising casing, and be installed in confocal fluorescent pick-up unit, scanister, processing of circuit module and communication module in the casing, wherein:
Casing is provided with socket;
Confocal fluorescent pick-up unit, scanister and communication module all are connected with the processing of circuit module;
Scanister is immuno-chromatographic test paper strip or micro-fluidic chip transmission scanister, is arranged on spigot.
7. the other detector of immunity bed according to claim 6 is characterized in that described confocal fluorescent pick-up unit is connected with the processing of circuit module by optical signal amplifying large compensation module.
8. the other detector of immunity bed according to claim 6 is characterized in that described communication module is a bluetooth module.
9. the other detector of immunity bed according to claim 6 is characterized in that described processing of circuit module also is connected with memory module.
10. the other detector of immunity bed according to claim 6 is characterized in that described processing of circuit module also is connected with display module.
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| CN201020664739XU CN201917521U (en) | 2010-12-17 | 2010-12-17 | Confocal fluorescent detection device and immunity bedside detector adopting same |
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| CN201020664739XU CN201917521U (en) | 2010-12-17 | 2010-12-17 | Confocal fluorescent detection device and immunity bedside detector adopting same |
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Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102621117A (en) * | 2012-03-09 | 2012-08-01 | 福建师范大学 | Living cell laser scanning co-focusing microscope imaging system |
| CN105142790A (en) * | 2013-04-25 | 2015-12-09 | 格莱恩比奥-奥内有限公司 | Method for filling a microfluidic device using a dispensing system and corresponding test system |
| CN105158226A (en) * | 2015-10-04 | 2015-12-16 | 张道允 | Medicinal fluorescent box |
| CN105445450A (en) * | 2015-12-30 | 2016-03-30 | 天津诺星生物医药科技有限公司 | Congestive heart failure detection system |
| CN105445461A (en) * | 2015-12-30 | 2016-03-30 | 天津诺星生物医药科技有限公司 | Cardiovascular and cerebrovascular disease detection system |
| CN105527445A (en) * | 2015-12-30 | 2016-04-27 | 天津诺星生物医药科技有限公司 | Acute myocardial infarction detection system |
| CN105548165A (en) * | 2015-12-29 | 2016-05-04 | 南京洁态环保科技有限公司 | Test paper reflectometer and measuring method for test paper surface |
| CN106018796A (en) * | 2016-07-05 | 2016-10-12 | 扬州千代科技有限公司 | Immunochromatographic detection system based on single-frequency excitation and double-frequency reception principle and detection method thereof |
| CN108007904A (en) * | 2016-10-27 | 2018-05-08 | 韩国帕克特生物科技有限公司 | The signal supervisory instrument and its detection method of band based on film |
| CN110118757A (en) * | 2018-02-05 | 2019-08-13 | 北京信息科技大学 | Light source compensation method and device for confocal LED-induced fluorescence detection |
| CN110132931A (en) * | 2019-06-17 | 2019-08-16 | 北京百康芯生物科技有限公司 | Lamp guide passes light without lens illumination imaging device and fluidic chip detecting system |
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2010
- 2010-12-17 CN CN201020664739XU patent/CN201917521U/en not_active Expired - Fee Related
Cited By (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102621117B (en) * | 2012-03-09 | 2014-03-12 | 福建师范大学 | Living cell laser scanning co-focusing microscope imaging system |
| CN102621117A (en) * | 2012-03-09 | 2012-08-01 | 福建师范大学 | Living cell laser scanning co-focusing microscope imaging system |
| CN105142790A (en) * | 2013-04-25 | 2015-12-09 | 格莱恩比奥-奥内有限公司 | Method for filling a microfluidic device using a dispensing system and corresponding test system |
| CN105142790B (en) * | 2013-04-25 | 2017-10-20 | 格莱恩比奥-奥内有限公司 | The method and corresponding test system of micro fluidic device are filled by distribution system |
| US9707560B2 (en) | 2013-04-25 | 2017-07-18 | Greiner Bio-One Gmbh | Method for filling a microfluidic device using a dispensing system and corresponding test system |
| CN105158226A (en) * | 2015-10-04 | 2015-12-16 | 张道允 | Medicinal fluorescent box |
| CN105548165A (en) * | 2015-12-29 | 2016-05-04 | 南京洁态环保科技有限公司 | Test paper reflectometer and measuring method for test paper surface |
| CN105527445B (en) * | 2015-12-30 | 2018-04-17 | 天津诺星生物医药科技有限公司 | A kind of acute myocardial infarction detecting system |
| CN105527445A (en) * | 2015-12-30 | 2016-04-27 | 天津诺星生物医药科技有限公司 | Acute myocardial infarction detection system |
| CN105445461A (en) * | 2015-12-30 | 2016-03-30 | 天津诺星生物医药科技有限公司 | Cardiovascular and cerebrovascular disease detection system |
| CN105445450A (en) * | 2015-12-30 | 2016-03-30 | 天津诺星生物医药科技有限公司 | Congestive heart failure detection system |
| CN106018796A (en) * | 2016-07-05 | 2016-10-12 | 扬州千代科技有限公司 | Immunochromatographic detection system based on single-frequency excitation and double-frequency reception principle and detection method thereof |
| CN106018796B (en) * | 2016-07-05 | 2017-10-13 | 扬州千代科技有限公司 | A kind of immunochromatography detecting system and its detection method for exciting dual frequency reception principle based on single-frequency |
| CN108007904A (en) * | 2016-10-27 | 2018-05-08 | 韩国帕克特生物科技有限公司 | The signal supervisory instrument and its detection method of band based on film |
| CN110118757A (en) * | 2018-02-05 | 2019-08-13 | 北京信息科技大学 | Light source compensation method and device for confocal LED-induced fluorescence detection |
| CN110118757B (en) * | 2018-02-05 | 2021-07-06 | 北京信息科技大学 | Light source compensation method and device for confocal LED induced fluorescence detection |
| CN110132931A (en) * | 2019-06-17 | 2019-08-16 | 北京百康芯生物科技有限公司 | Lamp guide passes light without lens illumination imaging device and fluidic chip detecting system |
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| Date | Code | Title | Description |
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| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20110803 Termination date: 20151217 |
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| EXPY | Termination of patent right or utility model |