CN201834907U - Semi-closed rail - Google Patents
Semi-closed rail Download PDFInfo
- Publication number
- CN201834907U CN201834907U CN2010201609601U CN201020160960U CN201834907U CN 201834907 U CN201834907 U CN 201834907U CN 2010201609601 U CN2010201609601 U CN 2010201609601U CN 201020160960 U CN201020160960 U CN 201020160960U CN 201834907 U CN201834907 U CN 201834907U
- Authority
- CN
- China
- Prior art keywords
- chip
- fence
- rail
- film
- well
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 238000002966 oligonucleotide array Methods 0.000 claims abstract description 12
- 239000000758 substrate Substances 0.000 claims abstract description 8
- 239000010408 film Substances 0.000 claims description 23
- 239000002362 mulch Substances 0.000 claims description 8
- 239000010409 thin film Substances 0.000 claims description 6
- 238000000018 DNA microarray Methods 0.000 abstract description 5
- 238000007789 sealing Methods 0.000 abstract description 4
- 230000000694 effects Effects 0.000 abstract description 3
- 230000002035 prolonged effect Effects 0.000 abstract 2
- 238000001514 detection method Methods 0.000 abstract 1
- 238000005070 sampling Methods 0.000 abstract 1
- 238000009396 hybridization Methods 0.000 description 8
- 108091034117 Oligonucleotide Proteins 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 230000000903 blocking effect Effects 0.000 description 2
- 238000011109 contamination Methods 0.000 description 2
- 230000007812 deficiency Effects 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
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- Apparatus Associated With Microorganisms And Enzymes (AREA)
Abstract
The utility model belongs to the field of biochip detection equipment, in particular to a semi-closed rail, which consists of a chip rail (1), wherein rail holes (5) corresponding to positions of oligonucleotide arrays of a substrate (4) are arranged on the chip rail (1). The utility model is characterized in that a layer of film (3) is also covered on the chip rail surface, sample adding holes (2) are arranged on the film (3) corresponding to the rail holes (5), sample adding hole covering films (6) are arranged on the sampling holes (2), and the crossed pollution between different oligonucleotide arrays can be blocked through the rail layer. The film layer can also realize the sealing effect before the sample adding through being covered on the chip rail layer, so the direct contact between the oligonucleotide arrays in the finished product chip and the air is prolonged, the service life of the chip is prolonged, and the product has a simple structure and a wide use range and is flexible to operate.
Description
Technical field: the utility model belongs to the biochip test apparatus field, specifically is a kind of semi-enclosed fence.
Background technology: the employed oligonucleotide chip fence in biochip field designs for long strip shape at present, the centre offers square fence hole, be affixed on the substrate and oligonucleotide arrays on the chip can be surrounded, application of sample carries out the intersection between the different oligonucleotide arrays then, but this oligonucleotide chip fence design has only one deck, need in the operating process by hybridization solution is joined in the oligonucleotide arrays, though and the crossed contamination between the present design different oligonucleotide arrays capable of blocking, but can't play the sealing function before the application of sample, the chip time limit of service just must be used when the application of sample and the cover plate of the similar specification in square fence hole in order to prolong, but the very trouble that operates, and the flexible selectivity of application of sample is not ideal enough.
Summary of the invention: the utility model is poor in order to overcome in the prior art oligonucleotide chip fence design stopping property, and the not enough technological deficiency of flexible selectivity of application of sample, for people provide a kind of simple in structure, good sealing effect, the flexible selectivity height of application of sample, can prolong the semi-enclosed fence of chip time limit of service.
The purpose of this utility model realizes by following technical proposals.
Of the present utility model semi-enclosed fence is made of chip fence 1, and chip fence 1 is provided with the fence hole 5 corresponding with the oligonucleotide arrays position of substrate 4, is characterized in also being coated with thin film 3 on the chip fence face.
Film 3 corresponding with described fence hole 5 in the such scheme is provided with well 2, and well 2 is provided with well mulch film 6.
The technical scheme of the utility model science practicality that to be the designer explore out by long-term practice repeatedly, because the utility model improves at the technological deficiency of existing chip fence, being about to the chip fence is designed to two-layer, the first layer is band fence hole 5 chip fence layers, the crossed contamination between this fence layer different oligonucleotide arrays capable of blocking; The second layer is the well thin film layer, and this thin film layer covers on the chip fence layer can play sealing function before application of sample, and the oligonucleotide arrays that can prolong in the finished chip directly contacts with air, prolongs the chip time limit of service.The utility model can play the effect of traditional fence and the two function sum of chip cover plate simultaneously.Can be affixed on separately on the chip, also can before product chips is dispatched from the factory, stick on.Adopt product of the present utility model, can be directly by pipettor in well joins hybridization solution as shown in Figure 2 liquid hybridization reserving space, after hybridization is finished this fence second layer torn and develops a film and can pass through the scanner extraction data.During operation, can select any well to carry out application of sample, thereby the flexible selectivity of operation is improved, expand the use range of fence greatly, make it more convenient to use.
Further describe the utility model below by embodiment, the utility model is not limited only to described embodiment.
Description of drawings:
Fig. 1 is the two dimensional structure synoptic diagram of semi-enclosed fence.
Fig. 2 is the sectional structure synoptic diagram of semi-enclosed fence.
Among the figure: 1. chip fence; 2. well; 3. film; 4. substrate; 5. fence hole; 6. well mulch film; 7. liquid hybridization reserving space.
Embodiment:
Shown in Fig. 1～2: of the present utility model semi-enclosed fence, constitute by chip fence 1, chip fence 1 is provided with the fence hole 5 corresponding with the oligonucleotide arrays position of substrate 4, is characterized in also being coated with on 1 of the chip fence thin film or claims thin slice 3.This example and described fence hole 5 corresponding films 3 are provided with well 2, and well 2 is provided with well mulch film 6.When presetting well 2 holes on the film 3, beat well at required correspondence position in the time of can operating temporarily.But better be default well 2 on film 3.Well 2 is provided with well mulch film 6.Well mulch film 6 can be as a whole with film 3, when film 3 is made at this moment the film at well 2 places made the thinner well mulch film 6 that is; Well mulch film 6 also can be to reserve the thin film that covers again on the well 2 on the film 3.The size of above-mentioned fence hole 5 and well 2, shape, position can be adjusted as required.
The chip fence 1 in fence hole 5 is attached on the substrate 4 that has biochip, film 3 can cover temporarily, better be that the chip fence 1 that will be coated with film 3 fence holes 5 is attached to together sale on the substrate that has biochip, puncture well 2 on the film 3 with pipettor during use, by well 2 hybridization solution is joined in the liquid hybridization reserving space 7, will tear and develop a film and to extract desired data by scanner with the chip fence 1 in fence hole 5 after hybridization is finished.
Claims (2)
1. the semi-enclosed fence of basis is made of chip fence (1), and chip fence (1) is provided with the fence hole (5) corresponding with the oligonucleotide arrays position of substrate (4), it is characterized in that also being coated with on the chip fence face thin film (3).
2. according to described semi-enclosed fence of claim 1, it is characterized in that the corresponding film (3) in described fence hole (5) is provided with well (2), well (2) is provided with well mulch film (6).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010201609601U CN201834907U (en) | 2010-04-15 | 2010-04-15 | Semi-closed rail |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010201609601U CN201834907U (en) | 2010-04-15 | 2010-04-15 | Semi-closed rail |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN201834907U true CN201834907U (en) | 2011-05-18 |
Family
ID=44005011
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2010201609601U Expired - Fee Related CN201834907U (en) | 2010-04-15 | 2010-04-15 | Semi-closed rail |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN201834907U (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108070582A (en) * | 2012-10-31 | 2018-05-25 | 伯克利之光生命科技公司 | For the fence of the micro- target of biology |
-
2010
- 2010-04-15 CN CN2010201609601U patent/CN201834907U/en not_active Expired - Fee Related
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108070582A (en) * | 2012-10-31 | 2018-05-25 | 伯克利之光生命科技公司 | For the fence of the micro- target of biology |
| CN108070582B (en) * | 2012-10-31 | 2021-09-14 | 伯克利之光生命科技公司 | Enclosure for biological micro-objects |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20110518 Termination date: 20150415 |
|
| EXPY | Termination of patent right or utility model |