CN201216811Y - Integrated structure of transdermal drug delivery fine needle array and flexible forming face pack - Google Patents
Integrated structure of transdermal drug delivery fine needle array and flexible forming face pack Download PDFInfo
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- CN201216811Y CN201216811Y CNU2008201087290U CN200820108729U CN201216811Y CN 201216811 Y CN201216811 Y CN 201216811Y CN U2008201087290 U CNU2008201087290 U CN U2008201087290U CN 200820108729 U CN200820108729 U CN 200820108729U CN 201216811 Y CN201216811 Y CN 201216811Y
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- facial mask
- microneedle array
- microspring
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- soft
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0023—Drug applicators using microneedles
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- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Medical Informatics (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Media Introduction/Drainage Providing Device (AREA)
Abstract
The utility model provides an integrated structure of a micro needle array and a soft shaping facial mask of transdermal delivery, which comprises the soft shaping facial mask, a micro-spring, the micro needle array and a soft memberance, wherein, the soft shaping facial mask comprises a cyst cavity formed on the face pack, a basement membrane arranged below the cyst cavity, and a pore formed inside the face pack material; the micro-spring is installed in the cyst cavity of the soft shaping facial mask, and the base of the micro-spring is connected with the inner side surface of the basement membrane of the soft shaping facial mask; the micro needle array is embedded in the cyst cavity of the soft shaping facial mask in the direction of a needlepoint pointing downwards to the basement membrane, and the base of the micro needle array is connected with the top end of the micro-spring; and the soft memberance is combined on the surface of the cyst cavity opening side of the facial mask. The integrated structure is particularly suitable for large-area transdermal transmission of facial care polymer drugs.
Description
Technical field
This utility model relates to the integrated morphology of a kind of transdermal administration microneedle array and soft forming facial mask.
Background technology
Infiltration has the face lining sheet material of skin care drug composition to belong to the category of transdermal administration on elementary introduction to drug delivery technique.Epidermal growth factor in the skin care drug, transforming growth factor, elastin laminin, collagen protein, hyaluronic acid mostly are macromolecule, and its transdermal absorption factor is because cuticular barrier action and very low.Even use supplementary meanss such as ionization infiltration, ultrasound wave, still be difficult to significantly improve its transdermal absorption factor.
Be to strengthen the transdermal absorption factor of polymer drug, people have proposed to utilize the microneedle array of little fabrication process to pierce through keratodermatitis and have formed a large amount of micropores that pass through for polymer drugs.Micropin is divided into solid and hollow from structure.Wherein, solid microneedles carries medicine that two kinds of common modes are arranged again: a kind of is the hydrophilic medicinal liquid to be coated with to be plated on the micropin in advance, micropin is trapped in active epidermis or intradermal a period of time after passing horny layer, so that the medicinal liquid of coating is discharged into active epidermis or intradermal (referring to Mark R.Prausnitz, Microneedles for Transdermal Drug Delivery, Advanced Drug Delivery Review56 (2004): pp 581-587), i.e. " plating thorn formula ".Another kind of mode is directly to extract at once then with the microneedle horny layer, again at skin surface spreading medicinal liquid or medicine film, the micro channel that medicinal liquid forms at skin surface by micropin enters active epidermis or intradermal (referring to Mark R.Prausnitz, Microneedles forTransdermal Drug Delivery, Advanced Drug Delivery Review 56 (2004): pp581-587), i.e. " thorn applies formula ".Compare with the solid microneedles array, the mechanical strength of empty micropin array is lower, easy to break.
No matter be solid microneedles or empty micropin, the structure of existing micropin drug-supplying system all is not directly applied for the transdermal delivery of face protection medicine.Main cause is:
1, how much pasting property are poor.Face protection often needs to cover large-area skin of face.Existing microneedle array is many to be made on rigid base.Because the uneven curvature of skin of face is obviously no longer suitable based on the microneedle array of rigid base.
2, manually pull out pin.After being used to complete, microneedle array needs to break away from skin.Existing microneedle array all adopts and manually extracts microneedle array from skin because the base area of array is less.And face protection need cover large-area skin of face, and re-use this moment pulls out manually that pin not only bothers, difficulty, and causes fractureing of micropin easily.The micropin that fractures remains in the skin of face, will be very unfavorable to skin.Empty micropin easily fractures, and hollow pipe stops up in penetrating the process of skin histology easily than solid microneedles is lower owing to mechanical strength especially.
3, service routine is more loaded down with trivial details.The dose that can carry on " plating thorn formula " solid microneedles is limited, then wants multi-disc microneedle array continuous several times to use if will reach face protection institute expense." thorn applies formula " solid microneedles need stick a needle into, extracts, apply then some steps such as medicinal liquid or medicine film earlier, and micropin and medicine are not integrated in one, and therefore uses also inconvenient.
At the problem of above-mentioned pasting property, Zhang Kai's journey etc. has proposed structure based on the micropin of soft substrate (referring to Chinese patent CN 1552476A; U.S. Pat 7273474B2).Soft substrate is tightly around the part of the sidewall of empty micropin, and is covered in the susceptor surface of empty micropin.To the top of microneedle array, sidewall areas and carry out ion implantation near the base area of sidewall, make the etch-rate of ion implantation zone in follow-up etching process slower than no ion implantation zone, thereby after the micropin etching finishes, base does not have ion implantation zone by etching fully, only stays ion implantation zone and soft substrate.This structure has solved the problem of pasting property, but still has following shortcoming:
(1) micropin is given prominence to the surface of soft substrate all the time, fractures easily in the process of thrusting, extracting at micropin like this and storing at ordinary times, sees Fig. 1.Fig. 1 represents that micropin needle body 111 is given prominence to all the time outside soft substrate 110, caused micropin to fracture easily in the prior art.The micropin that fractures is trapped in the skin 112, will be unfavorable to skin.
(2) do not solve the problem of pulling out pin after micropin thrusts skin.Therefore still exist by manually pulling out the potential danger that pin causes micropin to fracture.
(3) manufacturing process is loaded down with trivial details.Technologies such as needs are ion implantation, coating flexible material also need to install drug depot behind afterwards, and operation is more loaded down with trivial details relatively.
The utility model content
In order to improve the transdermal delivery that the Transdermal Delivery with Microneedle Array system makes it to be directly applied for the face protection medicine, this utility model provides a kind of and a plurality of microneedle arrays is integrated in infiltration integrated morphology in the soft forming facial mask face protection polymer drug, that have high porosity is arranged.
In order to achieve the above object, this utility model provides the integrated morphology of a kind of transdermal administration microneedle array and soft forming facial mask, this integrated morphology comprises: soft forming facial mask comprises counterdie, and the hole of face-mask material inside of thereon blister cavities of formation, blister cavities below; Microspring is placed in the blister cavities of soft forming facial mask, and the base of this Microspring engages with the inner surface of the counterdie of soft forming facial mask; Microneedle array, the direction of pointing to counterdie according to needle point down is inlaid in the blister cavities of soft forming facial mask, and the base of this microneedle array engages with the top of Microspring; And flexible film, be compounded on the surface of blister cavities opening one side of facial film.
Position relation and annexation between above-mentioned each ingredient are described below:
Blister cavities preparation on soft forming facial mask, a kind of preferable uniform distribution that is distributed as, the quantity of blister cavities and distribute spacing can be set arbitrarily.One end opening of each blister cavities is in a side surface of this facial film, and the other end does not run through facial film, but keeps the counterdie of this facial film bottom as facial film;
Settle Microspring in each blister cavities, the base of this Microspring engages with the counterdie of facial film;
Microneedle array is inlaid in the blister cavities of soft forming facial mask according to the direction that needle point points to the facial film counterdie down, and the base of microneedle array engages with the top of Microspring;
The transdermal administration medicinal liquid is soaked in the soft forming facial mask, by hole free flow in blister cavities and counterdie of face-mask material inside;
The base of pushing microneedle array makes the micropin needle point penetrate the counterdie and the keratodermatitis of facial film;
The inner surface rigidity or the flexible engagement of the base of this Microspring and the counterdie of soft forming facial mask, the base rigidity or the flexible engagement of the top of this Microspring and microneedle array;
Compound one deck flexible film on blister cavities opening one side surface of facial film, promptly envelope is thin, to seal each blister cavities.
Former grow up in the height of micropin needle body of design Microspring when not being subjected to the pressed by external force state makes the micropin needle point not give prominence to the counterdie of facial film when no pressed by external force.The rigidity of structure of design Microspring, make when the base of microneedle array is subjected to enough pressing forces, the deflection of Microspring is greater than skin deformation amount, skin keratin layer thickness, and counterdie thickness sum, microneedle array is penetrated the counterdie and the keratodermatitis of facial film, and the micropore that the medicinal liquid of infiltration in blister cavities and counterdie forms at keratodermatitis by micropin diffuses into the skin activity epidermal area so that skin corium; And when pushing after external force removes, the restoring force of Microspring is greater than the drag overall between microneedle array surface and keratodermatitis, active epidermal area, the forming facial mask counterdie, microneedle array so be able to bullet from skin, shrink back in the blister cavities of facial film.
This utility model with in the past based on the microneedle array of rigid base (referring to U.S. Pat 6743211B1; U.S. Pat 7226439B2; U.S. Pat 6908453B2; Chinese patent CN161969A; Chinese patent CN1817783A; Chinese patent CN1986011A) compare and have following three advantages:
1, is suitable for covering large-area skin of face, improved the pasting property of geometry of microneedle array and skin.
2, simple for structure integrated, facial film is the soft substrate of microneedle array, is again simultaneously transdermal administration medicinal liquid storage storehouse.Easy to use, simplified in the past that the solid microneedles array need thrust earlier, extract, the program of repaste drug of topical application liquid or medicine film.
3, Microspring design can realize pulling out pin automatically when large area skin is carried medicine, and microneedle array is reduced widely in the probability of using the back to fracture from the process that skin is taken off.
4, utilize infiltration to have the forming facial mask of medicinal liquid and the absorption affinity between the skin to be adjacent to skin all the time, also can not come off, further improved the pasting property of machinery of microneedle array and skin without adnexa is fixing.
This utility model and existing microneedle array based on soft substrate (referring to: Chinese patent CN1552476A; U.S. Pat 7273474B2) compare and have following six advantages:
1, microneedle array is inlaid in the facial film blister cavities, is transporting, storing, thrusts the mechanical protection that is subjected to facial film in the process.
2, Microspring design can realize pulling out pin automatically when large area skin is carried medicine, and microneedle array is reduced widely being used to complete the probability that the back fractures from the process that skin is taken off.
3, simple for structure integrated, the soft forming facial mask of high porosity is the soft substrate of microneedle array, is again the storage storehouse of transdermal administration medicinal liquid simultaneously.Simplified prior art (referring to Chinese patent CN 1552476A; U.S. Pat 7273474B2) need settle the design in extra drug storage storehouse in the behind of empty micropin array.
4, make simply, with low cost.Prior art (referring to: Chinese patent CN 1552476A; U.S. Pat 7273474B2) also need to increase ion implantation, extra technology such as coating flexible material etc. on little manufacturing process basis of micropin, technology is more relatively.And this utility model utilizes the production technology of existing forming facial mask to transform a little and can produce, and cost is low, technology is simple relatively.
5, the manufacturing of microneedle array and separate, the complete modularity of manufacturing as the facial film of soft substrate make microneedle array itself both can adopt the silicon materials manufacturing, more can adopt polymer or metal manufacturing.And prior art (referring to: Chinese patent CN 1552476A; U.S. Pat 7273474B2) owing to must realize soft substrate by the photoetch to the base of microneedle array, therefore having limited microneedle array can only adopt silicon materials, and can't adopt polymeric material.Because the biodegradability and the bio-compatibility of polymer obviously are better than silicon, so this utility model is better than prior art (referring to Chinese patent CN 1552476A aspect biological safety; U.S. Pat 7273474B2).
Description of drawings
The sketch map that Fig. 1 fractures based on the micropin needle body of soft substrate easily for prior art;
Fig. 2 is the integrated decomposing schematic representation of microneedle array 100 and soft forming facial mask 101 in this utility model;
Fig. 3 is inlaid in the interior partial cutaway schematic along A-A line among Fig. 2 of soft forming facial mask 101 blister cavities for microneedle array 100 in this utility model.
The specific embodiment
Below in conjunction with accompanying drawing this utility model is further elaborated.
With reference to Fig. 2, a plurality of microneedle arrays 100 are inlaid in respectively in each blister cavities 102 that prepared beforehand is good on the soft forming facial mask 101.Blister cavities 102 1 end openings are in a side surface 106 of facial film 101, and the other end does not run through facial film 101, but keep the counterdie 104 of the thickness of facial film 101 bottom 100-300 microns as facial film 101.Push each microneedle array 100 and make it to pierce through counterdie 104 and skin of face horny layer 103, make solid microneedles from moving by the Microspring 105 that is installed in each blister cavities 102 then, shrink back blister cavities 102 inside again from keratodermatitis 103.Simultaneously, utilize the storage storehouse of the thickness of facial film 101 itself as skin protection macromolecule medicinal liquid, but the hole free flow that the medicinal liquid of infiltration in facial film 101 sees through in the facial film 101 is arrived in each blister cavities 102, see through counterdie 104, the micropore that causes at keratodermatitis 103 through solid microneedles diffuses into skin activity epidermal area and skin corium again.After medicinal liquid is carried and to be finished and since micropin before this bullet in contraction of skin is returned blister cavities 102, therefore can be directly facial film 101 be taken off and is unlikelyly caused fractureing of micropin from skin surface.
With reference to Fig. 3, one of preferred version of the size of microneedle array base 109 is 4 millimeters * 4 millimeters, and thickness is generally at the 100-150 micron.Microneedle array generally is chosen for solid microneedles, and the preferred version of the diameter of needle body 107 is the 100-150 micron, and the preferred version of needle point diameter is 20 microns.Micropin is generally equidistant arrangement, and the OC preferred version of each micropin is the 600-800 micron.Microneedle array 100 can be silicon, metal or polymeric material according to existing little manufacturing process preparation.The preferred thickness of soft forming facial mask 101 is 1 millimeter, can choose in existing various forming facial mask materials, and a kind of preferred materials is a spun-laced nonwoven fabric.The a plurality of equally distributed blister cavities 102 of preparation on facial film 101.Each blister cavities 102 is at a side surface 106 of facial film 101 (i.e. the surface that does not directly contact with skin) opening, and the size of opening equals or be slightly larger than the size of microneedle array base 109.Blister cavities 102 does not run through facial film 101, but keeps the counterdie 104 of the thickness of facial film 101 bottom 100-300 microns as facial film 101.The making of blister cavities 102 can be chosen in existing manufacturing technique, places on the supporting mass have the projection of making by the blister cavities shape from the teeth outwards for the fibre web that will wet and carries out spunlaced as a kind of preferred version.
The transdermal administration medicinal liquid is soaked in the soft forming facial mask 101, by hole free flow in blister cavities 102 and counterdie 104 of face-mask material inside.
Settle Microspring 105 in each blister cavities 102, the base 121 of this Microspring 105 engages with the inner surface of the counterdie 104 of facial film 101.The design of Microspring 105 can be chosen in existing various Microspring organization plans.Microneedle array 100 is inlaid in the blister cavities 102 of soft forming facial mask 101 according to the direction that needle point points to the counterdie 104 of facial film 101 down, and the base 109 of microneedle array 100 engages with the top 120 of Microspring 105.Be example with the beam type Microspring only, Microspring can prepare separately, again with its top 120 and microneedle array base 109 rigidity or flexible engagement, and also can be by existing various little manufacturing process and microneedle array 100 and the preparation of microneedle array base 109 one.The base 121 of Microspring 105 and the inner surface rigidity or the flexible engagement of the counterdie 104 of facial film 101.The former length of Microspring 105 when not being subjected to the pressed by external force state is designed to the height more than or equal to micropin needle body 107, makes the micropin needle point not give prominence to the counterdie 104 of facial film 101 when no pressed by external force.
At last in the surface 106 compound one deck flexible films or the non-woven fabrics sealing surface membrane vesicle chamber 102 of blister cavities 102 openings one side of facial film 101.This flexible film or non-woven fabrics are envelope film 108.Thin film or non-woven fabrics can be chosen in existing polymeric material.Complex method can be chosen in existing various combination process, is that ultrasonic bonding is compound as a kind of preferred version.
During use, throw off packing, the infiltration medicinal liquid facial film 101 by and skin between absorption be adjacent to skin.Because micropin needle body 107 is encapsulated in the blister cavities 102 this moment, is subjected to the mechanical protection of facial film 101, can reduce greatly therefore that micropin in the above process is subjected to unexpected external force and the probability that fractures.Then, applying vertical external force pushes each microneedle array base 109 one by one and makes microneedle facial film counterdie 104 and skin of face horny layer 103.Microspring 105 compressive deformations in this process.
Regulate and control its rigidity of structure by the physical dimension and the material characteristics that change Microspring 105, make:
1, when applying when making the required pressing force of microneedle keratodermatitis 103 in the base 109 of microneedle array, the deflection of Microspring 105 is greater than skin deformation amount, keratodermatitis 103 thickness, and counterdie 104 thickness sums, micropin is pierced through keratodermatitis 103, thereby makes the medicinal liquid of infiltration in blister cavities 102 and counterdie 104 diffuse into the skin activity epidermal area so that skin corium by micropin at the micropore that keratodermatitis 103 forms.
2, after pressing force is removed, the restoring force of Microspring 105 is greater than the drag overall between microneedle array and keratodermatitis 103, active epidermal area, the facial film counterdie 104, thus make the former length of Microspring 105 recoveries, micropin bullet from skin, shrink back in the blister cavities 102.
Finish using, manually peel off facial film 101.Because micropin from moving from skin and shrinking back in the blister cavities 102, therefore is subjected to the mechanical protection of facial film 101 before this, reduced its probability that fractures in the process of facial film disengaging skin widely.
The above only is a preferable embodiment of the present utility model, when not being used to limit the scope that this utility model is implemented.All equalizations of being done according to this utility model claims change and modify, and all belong to protection domain of the present utility model.
Claims (6)
1, the integrated morphology of a kind of transdermal administration microneedle array and soft forming facial mask is characterized in that, this integrated morphology comprises:
Soft forming facial mask comprises counterdie, and the hole of face-mask material inside of thereon blister cavities of formation, blister cavities below;
Microspring is placed in the blister cavities of soft forming facial mask, and the base of this Microspring engages with the inner surface of the counterdie of soft forming facial mask;
Microneedle array, the direction of pointing to counterdie according to needle point down is inlaid in the blister cavities of soft forming facial mask, and the base of this microneedle array engages with the top of Microspring; And
Flexible film is compounded on the surface of blister cavities opening one side of facial film.
2, the integrated morphology of transdermal administration microneedle array as claimed in claim 1 and soft forming facial mask is characterized in that, the thickness of this facial film counterdie is the 100-300 micron.
3, the integrated morphology of transdermal administration microneedle array as claimed in claim 1 and soft forming facial mask, it is characterized in that, the inner surface rigidity or the flexible engagement of the base of this Microspring and the counterdie of soft forming facial mask, the base rigidity or the flexible engagement of the top of this Microspring and microneedle array.
4, the integrated morphology of transdermal administration microneedle array as claimed in claim 1 and soft forming facial mask is characterized in that, former grow up in the height of micropin needle body of this Microspring when not being subjected to the pressed by external force state.
5, the integrated morphology of transdermal administration microneedle array as claimed in claim 1 and soft forming facial mask, it is characterized in that, when being subjected to making the required pressing force of microneedle keratodermatitis, the deflection of this Microspring is greater than skin deformation amount, skin keratin layer thickness and counterdie thickness sum.
6, as the integrated morphology of claim 1 or 5 described transdermal administration microneedle arrays and soft forming facial mask, it is characterized in that, when pushing after external force removes, the restoring force of this Microspring is greater than the drag overall between each micropin surface and keratodermatitis, active epidermal area, the forming facial mask counterdie.
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| Application Number | Priority Date | Filing Date | Title |
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| CNU2008201087290U CN201216811Y (en) | 2008-06-19 | 2008-06-19 | Integrated structure of transdermal drug delivery fine needle array and flexible forming face pack |
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| CNU2008201087290U CN201216811Y (en) | 2008-06-19 | 2008-06-19 | Integrated structure of transdermal drug delivery fine needle array and flexible forming face pack |
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| CN201216811Y true CN201216811Y (en) | 2009-04-08 |
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Granted publication date: 20090408 Termination date: 20100619 |