CN201055536Y - High-bioavailability surface modified nano diamond plated film orthopaedics functional material - Google Patents
High-bioavailability surface modified nano diamond plated film orthopaedics functional material Download PDFInfo
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- CN201055536Y CN201055536Y CNU2007200032489U CN200720003248U CN201055536Y CN 201055536 Y CN201055536 Y CN 201055536Y CN U2007200032489 U CNU2007200032489 U CN U2007200032489U CN 200720003248 U CN200720003248 U CN 200720003248U CN 201055536 Y CN201055536 Y CN 201055536Y
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- Prior art keywords
- diamond
- titanium alloy
- functional material
- utility
- plated film
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- 239000000463 material Substances 0.000 title claims abstract description 12
- 239000002113 nanodiamond Substances 0.000 title claims description 16
- 229910052799 carbon Inorganic materials 0.000 claims abstract description 23
- 229910003460 diamond Inorganic materials 0.000 claims abstract description 20
- 239000010432 diamond Substances 0.000 claims abstract description 20
- 229910001069 Ti alloy Inorganic materials 0.000 claims abstract description 15
- 229910052751 metal Inorganic materials 0.000 claims abstract description 10
- 239000002184 metal Substances 0.000 claims abstract description 10
- 108090000765 processed proteins & peptides Proteins 0.000 claims abstract description 5
- 108090000623 proteins and genes Proteins 0.000 claims abstract description 5
- 102000004169 proteins and genes Human genes 0.000 claims abstract description 5
- 230000004048 modification Effects 0.000 claims description 9
- 238000012986 modification Methods 0.000 claims description 9
- 241000446313 Lamella Species 0.000 claims description 6
- 150000001247 metal acetylides Chemical class 0.000 claims description 6
- 238000005516 engineering process Methods 0.000 claims description 5
- 239000000758 substrate Substances 0.000 claims description 5
- 108020004414 DNA Proteins 0.000 claims description 4
- 238000000465 moulding Methods 0.000 claims description 2
- 238000007747 plating Methods 0.000 claims description 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract description 14
- 238000000576 coating method Methods 0.000 abstract description 12
- 239000000126 substance Substances 0.000 abstract description 12
- 238000000034 method Methods 0.000 abstract description 10
- 239000011248 coating agent Substances 0.000 abstract description 7
- 206010061218 Inflammation Diseases 0.000 abstract description 3
- 239000000956 alloy Substances 0.000 abstract description 3
- 230000004054 inflammatory process Effects 0.000 abstract description 3
- 210000000988 bone and bone Anatomy 0.000 abstract 2
- 239000011229 interlayer Substances 0.000 abstract 2
- 239000010410 layer Substances 0.000 abstract 2
- 230000000399 orthopedic effect Effects 0.000 abstract 2
- 206010067484 Adverse reaction Diseases 0.000 abstract 1
- 230000006838 adverse reaction Effects 0.000 abstract 1
- 150000003384 small molecules Chemical class 0.000 abstract 1
- 210000001519 tissue Anatomy 0.000 abstract 1
- 150000003608 titanium Chemical class 0.000 abstract 1
- 238000000151 deposition Methods 0.000 description 11
- 230000008020 evaporation Effects 0.000 description 9
- 238000001704 evaporation Methods 0.000 description 9
- 229910052739 hydrogen Inorganic materials 0.000 description 6
- 238000009501 film coating Methods 0.000 description 5
- 239000012528 membrane Substances 0.000 description 5
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 4
- 238000006243 chemical reaction Methods 0.000 description 4
- 238000005137 deposition process Methods 0.000 description 4
- 239000007888 film coating Substances 0.000 description 4
- 229910002804 graphite Inorganic materials 0.000 description 4
- 239000010439 graphite Substances 0.000 description 4
- 238000004050 hot filament vapor deposition Methods 0.000 description 4
- 238000004518 low pressure chemical vapour deposition Methods 0.000 description 4
- 239000000725 suspension Substances 0.000 description 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 3
- 239000001257 hydrogen Substances 0.000 description 3
- 238000007733 ion plating Methods 0.000 description 3
- 239000002253 acid Substances 0.000 description 2
- -1 aldehyde radical Chemical class 0.000 description 2
- 125000003368 amide group Chemical group 0.000 description 2
- 125000004429 atom Chemical group 0.000 description 2
- 239000012876 carrier material Substances 0.000 description 2
- 238000004140 cleaning Methods 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 230000008021 deposition Effects 0.000 description 2
- 238000006073 displacement reaction Methods 0.000 description 2
- 239000007943 implant Substances 0.000 description 2
- 238000010884 ion-beam technique Methods 0.000 description 2
- 239000003595 mist Substances 0.000 description 2
- 230000006911 nucleation Effects 0.000 description 2
- 238000010899 nucleation Methods 0.000 description 2
- 230000010355 oscillation Effects 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 238000005268 plasma chemical vapour deposition Methods 0.000 description 2
- 238000007750 plasma spraying Methods 0.000 description 2
- 239000012495 reaction gas Substances 0.000 description 2
- 125000003396 thiol group Chemical group [H]S* 0.000 description 2
- 239000012620 biological material Substances 0.000 description 1
- 238000002316 cosmetic surgery Methods 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000002513 implantation Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000012567 medical material Substances 0.000 description 1
- 239000002120 nanofilm Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 230000036299 sexual function Effects 0.000 description 1
- 238000002604 ultrasonography Methods 0.000 description 1
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- Materials For Medical Uses (AREA)
Abstract
The utility model relates to a high biological compatibility surface modified nanometer diamond coating orthopedics function material, which is a modified titanium alloy artificial articulation, bone plate and bone peg material structure. The utility model comprises a high density nuclear layer or metallic carbide inter layer which are formed on an orthopedics function material metal plate carrier. A diamond or diamond like carbon coating is plated on the inter layer. A diamond film is combined with and fixes the linkage molecule interface layer of a DNA, a protein, a peptide and a small molecule in covalent bond. The good biological compatibility and chemical stability of the diamond coating are used by the utility model, which solves the problem that minim ion releasing and polluting tissue causing inflammation and other adverse reactions exist in the process of titanium alloy material being embedded in human body.
Description
Technical field
This utility model belongs to technical field of biological material, particularly the technology of artificial joint, blade plate and the nail surface modification used of titanium alloy surface modification technology orthopaedics.
Background technology
Titanium alloy is the functional material of aspect extensive uses such as orthopaedics, dentistry, plastic surgery.But titanium alloy material still exists and can discharge by micro ion in the state of implant into body, pollutes tissue, can cause the problem of untoward reaction such as inflammation.Therefore and diamond film has maximum hardness, low-friction coefficient, optimum chemical stability and high good biocompatibility, and depositing diamond film has the value of practical application on the medical material surface.
Novel content
The purpose of this utility model is to overcome the above-mentioned deficiency of prior art, provides a kind of with coated by Nano diamond or diamond-like carbon film coating, titanium alloy artificial joint, hone lamella and nail has been carried out the high-biocompatibility orthopaedics functional material of surface modification.
The purpose of this utility model is achieved through the following technical solutions.
A kind of coated by Nano diamond orthopaedics functional material of high-biocompatibility surface modification, carry out artificial joint, hone lamella and the nail of the titanium alloy substrate of surface modification treatment for the applying nano technology, it comprises metallic plate carrier, high density stratum nucleare or metal carbides intermediate layer, diamond or diamond-like-carbon plated film and bonding molecule interface layer.Molding high density stratum nucleare or metal carbides intermediate layer on orthopaedics functional material metallic plate carrier, plating is with diamond or diamond-like-carbon plated film on the intermediate layer, diamond thin carries out after the rear surface handles, formation can covalent in conjunction with fixed dna, protein, peptide, micromolecular bonding molecule interface layer.
Diamond or diamond-like-carbon plated film, the titanium alloy object surface that has been shaped in actual specification, shape and size is after pretreatment, and the thickness that adopts chemical vapor coating method or physical vapor vapour deposition method that the titanium alloy substrate is coated with is nano-diamond film or the diamond-like carbon film of 100nm～3 μ m.The surface preparation of titanium alloy substrate, can use acid or aqueous slkali to handle, by particle diameter 30 μ m microdiamond suspension 400W cleaned by ultrasonic vibration 10-20min, reach 0.3 μ m Nano diamond suspension and be two-part supersonic oscillations processing 10-20min, dry up standby after the reuse acetone ultrasonic waves for cleaning.
The formation of nano-diamond membrane coating for control nucleation period back bias voltage (Bias) is worth in 100-280V, reaction gas pressure 0.8-3.5Kpa, is used 0.1～3.0% CH
4, 99.9～97% H
2And 99.9～97% H
2Mist is grown under 500～2100 ℃ plasma environment, and content is higher than 70% SP
3The glomerocryst nano-diamond membrane of carbon atom bond structure generates the nano-diamond membrane coating that thickness is lower than 3 μ m under the chemical vapor coating environment.Being coated with of diamond-like-carbon plated film, be to use metal and graphite target, under physical vapor evaporation environment, generate the metal carbides intermediate layer that thickness is lower than 30nm, re-use graphite target, under physical vapor evaporation environment, generate the diamond-like carbon film coating that thickness is lower than 1 μ m.
The chemical vapor coating method of nano-diamond membrane is meant the method for utilizing hot filament CVD (HFCVD), DC plasma and chemical gas-phase deposition method (DCPCVD), direct-current plasma spraying process, radio frequency plasma vapour deposition process (RFPCVD), high-frequency plasma vapour deposition process, direct-current arc electric discharge, microwave plasma CVD method (MWPCVD), ion beam depositing method IBD or low-pressure chemical vapor deposition (LPCVD).The physical vapor vapour deposition method of nano-diamond membrane is meant that the method for utilizing evaporation mode, ion plating or sputter realizes the nanoscale plated film of low pin hole rate, and this film is that content is lower than 70% SP
3Carbon atom bond structure thing.
The rear surface processing mode is meant with hydrogen plasma displacement surface molecular, ion or atom, again with chemical compound reactions such as aldehyde radical, amido or sulfhydryls, with covalent bonds other end fixed dna, protein, peptide or micromolecular interface layer.
This utility model has utilized diamond film excellent biological compatibility and best chemical stability, has solved the micro ion release that titanium alloy material exists in the implant into body process, has polluted the problem of organizing, causing untoward reaction such as inflammation.
Description of drawings
Fig. 1 is a structural representation of the present utility model.
Among the figure: 1. metallic plate carrier, 2. high density stratum nucleare or metal carbides intermediate layer, 3. diamond or diamond-like-carbon plated film, 4. bonding molecule interface layer.
The specific embodiment
With reference to accompanying drawing, this utility model adopts chemical vapor coating method or physical vapor vapour deposition method, associated metal plate carrier materials 1 such as titanium alloy artificial joint, hone lamella and nail are carried out surface modification, this nano-diamond film or diamond-like carbon film 3 can be implemented the rear surface again and handle, to cooperate the different functional requirements of implanting environment and position.Method is with after the titanium alloy object surface pretreatment that is shaped, through chemical vapor coating method or physical vapor vapour deposition method the titanium alloy substrate is coated with, formation thickness is nano-diamond film or the diamond-like carbon film 3 of 100nm～3 μ m, this diamond thin can be implemented the rear surface again and handle, with covalent in conjunction with the high molecule interface layer 4 of the tissue compatibility.
Two kinds of diamond coated ways such as following mode:
First kind, refer to contain SP
3The carbon atom bond structure is higher than the nano polycrystal diamond film production of 70% content.
For improving coated by Nano diamond plated film bond strength and nucleating layer 2 density greater than 10
9Cm
-1The surface of metallic plate carrier materials 1 such as artificial joint, hone lamella and nail uses acid or aqueous slkali to handle in advance, by particle diameter 30 μ m microdiamond suspension 400w cleaned by ultrasonic vibration 10-20min, and 0.3 μ m Nano diamond suspension is two-part supersonic oscillations processing 10-20min, dry up after cleaning with acetone ultrasound wave mode at last standby, and control nucleation period back bias voltage (Bias) to be worth in 100-280V and reaction gas pressure be 0.8-3.5Kpa.Use 0.1～3.0% CH
4, 20～70% Ar
2And 79.9～27% H
2Mist, plated film under the plasma environment of 500～2100 ℃ chemical vapor coating methods.The chemical vapor coating environment can utilize following method to obtain: hot filament CVD (HFCVD), DC plasma and chemical gas-phase deposition method (DCPCVD), direct-current plasma spraying process, radio frequency plasma vapour deposition process (RFPCVD), high-frequency plasma vapour deposition process, direct-current arc electric discharge, microwave plasma CVD method (MWPCVD), ion beam depositing method (IBD) or low-pressure chemical vapor deposition (LPCVD) etc. form the diamond nano film coating 3 that thickness is lower than 3 μ m.
Second kind, refer to contain SP
3The carbon atom bond structure be lower than the making of nanometer diamond-like-carbon (DLC) film 3 of 70% content, generate the diamond-like carbon film that thickness is lower than 1 μ m with physical vapor evaporation environment.This evaporation environment refers to utilize relevant devices such as evaporation (Evaporation Deposition) mode, ion plating (Ion Plating) mode or sputter (SputteringDeposition) mode, make thickness and be lower than 1 μ m, the diamond-like carbon film of no hydrogen content (3) deposition realizes hanging down nanoscale diamond-like-carbon (DLC) the film coating of pin hole rate.For improving material (1) surface bonding strengths such as artificial joint, hone lamella and nail, the making of nanometer diamond-like-carbon (DLC) film, use earlier metal and graphite to generate the metal carbides intermediate layer 2 that thickness is lower than 30nm as the target evaporation, re-using graphite target is raw material, generates the diamond-like carbon film coating that thickness is lower than 1 μ m under physical vapor evaporation environment.
This diamond thin or diamond-like carbon film are implemented the rear surface again and are handled, with covalent in conjunction with the high molecule interface layer 4 of the tissue compatibility, to cooperate the implantation sexual function demand of varying environment and position.The rear surface processing mode is meant with hydrogen plasma displacement surface molecular, ion or atom, again with chemical compound reactions such as aldehyde radical, amido or sulfhydryls, with covalent bonds other end fixed dna, protein, peptide or micromolecular interface layer, to cooperate the functional requirement of varying environment and position.
Claims (1)
1. the coated by Nano diamond orthopaedics functional material of a high-biocompatibility surface modification, carry out artificial joint, hone lamella and the nail of the titanium alloy substrate of surface modification treatment for the applying nano technology, it is characterized in that: this structure comprises orthopaedics functional material metallic plate carrier (1) upward molding high density stratum nucleare or metal carbides intermediate layer (2), plating is gone up with diamond or diamond-like-carbon plated film (3) in intermediate layer (2), diamond thin with covalent in conjunction with fixed dna, protein, peptide, micromolecular bonding molecule interface layer (4).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNU2007200032489U CN201055536Y (en) | 2007-02-05 | 2007-02-05 | High-bioavailability surface modified nano diamond plated film orthopaedics functional material |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNU2007200032489U CN201055536Y (en) | 2007-02-05 | 2007-02-05 | High-bioavailability surface modified nano diamond plated film orthopaedics functional material |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN201055536Y true CN201055536Y (en) | 2008-05-07 |
Family
ID=39424379
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNU2007200032489U Expired - Fee Related CN201055536Y (en) | 2007-02-05 | 2007-02-05 | High-bioavailability surface modified nano diamond plated film orthopaedics functional material |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN201055536Y (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102051579A (en) * | 2011-01-25 | 2011-05-11 | 中山大学 | Method for preparing carboxyl modified layer on surface of diamond-like carbon (DLC) film and DLC film prepared by method |
-
2007
- 2007-02-05 CN CNU2007200032489U patent/CN201055536Y/en not_active Expired - Fee Related
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102051579A (en) * | 2011-01-25 | 2011-05-11 | 中山大学 | Method for preparing carboxyl modified layer on surface of diamond-like carbon (DLC) film and DLC film prepared by method |
| CN102051579B (en) * | 2011-01-25 | 2013-04-10 | 中山大学 | Method for preparing carboxyl modified layer on surface of diamond-like carbon (DLC) film and DLC film prepared thereby |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C57 | Notification of unclear or unknown address | ||
| DD01 | Delivery of document by public notice |
Addressee: Chen Youzhen Document name: Notification of Termination of Patent Right |
|
| C17 | Cessation of patent right | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20080507 |