CN200963204Y - Biological degradable netted artificial chest wall - Google Patents
Biological degradable netted artificial chest wall Download PDFInfo
- Publication number
- CN200963204Y CN200963204Y CN 200620044851 CN200620044851U CN200963204Y CN 200963204 Y CN200963204 Y CN 200963204Y CN 200620044851 CN200620044851 CN 200620044851 CN 200620044851 U CN200620044851 U CN 200620044851U CN 200963204 Y CN200963204 Y CN 200963204Y
- Authority
- CN
- China
- Prior art keywords
- chest wall
- wall
- artificial
- artificial chest
- net
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 210000000779 thoracic wall Anatomy 0.000 title claims abstract description 38
- 102000008186 Collagen Human genes 0.000 claims abstract description 14
- 108010035532 Collagen Proteins 0.000 claims abstract description 14
- 229920001661 Chitosan Polymers 0.000 claims abstract description 12
- 239000012620 biological material Substances 0.000 claims abstract description 11
- 210000001835 viscera Anatomy 0.000 claims abstract description 11
- 229920002463 poly(p-dioxanone) polymer Polymers 0.000 claims abstract description 8
- 210000000481 breast Anatomy 0.000 claims description 13
- 239000000835 fiber Substances 0.000 claims description 9
- 229920005615 natural polymer Polymers 0.000 claims description 7
- 239000000622 polydioxanone Substances 0.000 claims description 6
- 230000000149 penetrating effect Effects 0.000 claims description 3
- 239000000463 material Substances 0.000 abstract description 18
- 238000002360 preparation method Methods 0.000 abstract description 7
- 229920001436 collagen Polymers 0.000 abstract description 6
- 238000001035 drying Methods 0.000 abstract description 6
- 238000000034 method Methods 0.000 abstract description 5
- 230000029058 respiratory gaseous exchange Effects 0.000 abstract description 4
- 230000001954 sterilising effect Effects 0.000 abstract description 4
- 230000007774 longterm Effects 0.000 abstract description 3
- 230000000803 paradoxical effect Effects 0.000 abstract description 3
- 239000003814 drug Substances 0.000 abstract description 2
- 210000000056 organ Anatomy 0.000 abstract description 2
- 230000006641 stabilisation Effects 0.000 abstract description 2
- 238000011105 stabilization Methods 0.000 abstract description 2
- 239000012466 permeate Substances 0.000 abstract 1
- 210000001519 tissue Anatomy 0.000 description 10
- 238000007789 sealing Methods 0.000 description 7
- 230000015556 catabolic process Effects 0.000 description 5
- 238000006731 degradation reaction Methods 0.000 description 5
- 238000007731 hot pressing Methods 0.000 description 5
- 230000002980 postoperative effect Effects 0.000 description 5
- 238000012545 processing Methods 0.000 description 5
- 206010013786 Dry skin Diseases 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 239000003795 chemical substances by application Substances 0.000 description 3
- 239000002131 composite material Substances 0.000 description 3
- 238000005485 electric heating Methods 0.000 description 3
- 238000011049 filling Methods 0.000 description 3
- 238000000465 moulding Methods 0.000 description 3
- 238000004659 sterilization and disinfection Methods 0.000 description 3
- 238000009954 braiding Methods 0.000 description 2
- 239000011248 coating agent Substances 0.000 description 2
- 238000000576 coating method Methods 0.000 description 2
- 230000008878 coupling Effects 0.000 description 2
- 238000010168 coupling process Methods 0.000 description 2
- 238000005859 coupling reaction Methods 0.000 description 2
- 230000007547 defect Effects 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- 239000010410 layer Substances 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 239000004632 polycaprolactone Substances 0.000 description 2
- -1 polypropylene Polymers 0.000 description 2
- 229920001343 polytetrafluoroethylene Polymers 0.000 description 2
- 239000004810 polytetrafluoroethylene Substances 0.000 description 2
- 210000000115 thoracic cavity Anatomy 0.000 description 2
- 206010002091 Anaesthesia Diseases 0.000 description 1
- 229920002101 Chitin Polymers 0.000 description 1
- 206010010356 Congenital anomaly Diseases 0.000 description 1
- OTMSDBZUPAUEDD-UHFFFAOYSA-N Ethane Chemical compound CC OTMSDBZUPAUEDD-UHFFFAOYSA-N 0.000 description 1
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 1
- 229920005479 Lucite® Polymers 0.000 description 1
- 229920000339 Marlex Polymers 0.000 description 1
- 239000004743 Polypropylene Substances 0.000 description 1
- 206010040102 Seroma Diseases 0.000 description 1
- 208000025865 Ulcer Diseases 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000037005 anaesthesia Effects 0.000 description 1
- 208000008784 apnea Diseases 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 239000012237 artificial material Substances 0.000 description 1
- 238000005452 bending Methods 0.000 description 1
- 230000000975 bioactive effect Effects 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 208000037976 chronic inflammation Diseases 0.000 description 1
- 230000006020 chronic inflammation Effects 0.000 description 1
- QTCANKDTWWSCMR-UHFFFAOYSA-N costic aldehyde Natural products C1CCC(=C)C2CC(C(=C)C=O)CCC21C QTCANKDTWWSCMR-UHFFFAOYSA-N 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000006073 displacement reaction Methods 0.000 description 1
- 238000012142 en-bloc resection Methods 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 210000002950 fibroblast Anatomy 0.000 description 1
- 238000002513 implantation Methods 0.000 description 1
- 230000008595 infiltration Effects 0.000 description 1
- 238000001764 infiltration Methods 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000000977 initiatory effect Effects 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 230000003601 intercostal effect Effects 0.000 description 1
- 239000011229 interlayer Substances 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- ISTFUJWTQAMRGA-UHFFFAOYSA-N iso-beta-costal Natural products C1C(C(=C)C=O)CCC2(C)CCCC(C)=C21 ISTFUJWTQAMRGA-UHFFFAOYSA-N 0.000 description 1
- 238000013332 literature search Methods 0.000 description 1
- 229920002521 macromolecule Polymers 0.000 description 1
- 230000036244 malformation Effects 0.000 description 1
- 238000005399 mechanical ventilation Methods 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 208000018223 neoplasm of chest wall Diseases 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 230000036407 pain Effects 0.000 description 1
- 238000002559 palpation Methods 0.000 description 1
- 229920001610 polycaprolactone Polymers 0.000 description 1
- 239000004926 polymethyl methacrylate Substances 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 230000001172 regenerating effect Effects 0.000 description 1
- 230000008929 regeneration Effects 0.000 description 1
- 238000011069 regeneration method Methods 0.000 description 1
- 239000007779 soft material Substances 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 230000008467 tissue growth Effects 0.000 description 1
- 238000002627 tracheal intubation Methods 0.000 description 1
- 231100000397 ulcer Toxicity 0.000 description 1
Images
Landscapes
- Prostheses (AREA)
- Materials For Medical Uses (AREA)
Abstract
A bio-degradable reticular artificial chest wall belongs to bio-medicine, in particular to a bio-degradable simulated organs technical field. The artificial chest wall is characterized in that a porous reticular structure weaved by poly (p-dioxanone) monofilament is used as the material of artificial chest wall bracket; the collagen permeates homogeneously to cover and close the net holes; the natural polymeric biomaterial chitosan is used to cover the net wall towards the viscera evenly; the preparation method of the artificial chest wall is that plain woven method is used to weave the poly (p-dioxanone) monofilament to make the artificial chest wall network bracket; the network bracket is fixed the shape by heat press; the collagen is used to cover the surface and close the net holes of the network bracket fixed the shape; the net wall towards the viscera is covered with a coat of natural polymeric biomaterial chitosan, sterilizing and drying for use. The utility model is used to prevent the paradoxical respiration and maintain the stabilization of the chest wall at the early stage, additionally, the artificial chest wall is used as a tissue bracket to promote the growth of the tissue; then the artificial chest wall is degraded and absorbed gradually and finally is replaced by self tissue, thereby finishing the repair of the body and avoiding the long term complications caused by traditional materials.
Description
Technical field
Belong to biological medicine, particularly the simulated organ technical field of biodegradability exactly is a kind of manufacturing and application technology with reticular artificial chest wall of biodegradability.
Background technology
Treatment tumor of chest wall, radiation ulcer, infection, injure the chest wall defect that disease such as congenital malformation forms outward and need rebuild.Artificial material is used conveniently and is occupied an leading position in thoracic wall is rebuild owing to wide material sources.Yet at present still there is variety of issue in the material of using clinically: hard materials such as metal, lucite are because hardness is too high, and with the tissue bond ability, the later stage often can become flexible, be shifted, activity even deviate from; Soft material such as polypropylene (Marlex) net, polytetrafluoroethylene (PTFE) sticking patch and thoracic wall are organized more coupling, the reconstruction effect is better, but the long-term complication such as still often causing seroma, fistulization, pain, angiolysis and initiation infection of implanting, part patient's later stage needs operation once more to take out.
In recent years, the emphasis of biomaterial development is from avoiding causing body reaction, emphasizing that it is to pay attention to producing certain bioactive ingredients that biologically inert is transferred, to promote body and the favourable interaction of material production.The degradable macromolecule biomaterial provides new approach owing to have excellent biological compatibility, degradability and superior processing characteristics for developing ideal artificial breast wall material.
According to literature search, Chinese patent title: biodegradable artificial breast wall and preparation method thereof, Chinese patent application number: 200410025389.1, this patent mentions that adopting chitin fiber to strengthen polycaprolactone composite material is prepared into moulded board and the artificial rib of lath-shaped, with stainless steel silk with composite panel or rib and rib broken ends of fractured bone sutured.Though the composite of this method preparation is applied to the thoracic wall reparation and can guarantees thoracic wall stability, has certain feasibility, but as plate or strip hard material, still be difficult to combine together with tissue bond, poly-caprolactone degradation is slow simultaneously, reach more than 2 years, the implantation later stage still has possibility such as the complication that causes the material displacement, and the advantage of degradation material does not well embody.
Summary of the invention
This utility model provides a kind of and organizes more coupling with thoracic wall, and degradation property is good, the Biodegradable reticular artificial chest wall that degradation time is short.
The technical scheme that this utility model is taked:
Biodegradable reticular artificial chest wall, its scheme of taking is: the artificial breast wall support that is become porous network structure by polydioxanone monofilament fibrage; By collagen protein uniformly penetrating, covering, sealing mesh; And by the net wall of the even coverage rate of natural polymer biomaterial chitosan to internal organs.
The preparation method of Biodegradable reticular artificial chest wall is to operate according to the following steps, finishes the preparation of artificial breast wall:
1) adopts the plain woven method, the network of the thoracic wall form that braiding polydioxanone monofilament one-tenth is to be repaired;
2) with network on JX-826 electric heating hydraulic molding machine, hot pressing setting;
3) network of setting is done collagen protein covering surfaces and the processing of sealing mesh;
4) the net wall towards internal organs covers natural polymer biomaterial chitosan coat;
5) standby after sterilization, the dried.
The woven mesh support, its parameter is as follows: fibre diameter: 0.28mm, end count: 320/10cm, filling density: 230/10cm, the warp-wise tightness: 89.6%, broadwise tightness: 64.4%;
The hot pressing setting is at temperature 85-95 ℃, formalizes 5-10 second.
Doing collagen protein covering surfaces and the processing of sealing mesh, is network to be dipped in 2% collagen solution take out after 3 minutes, is placed on 40 ℃ of baking oven inner dryings, repeats aforesaid operations 2-3 time;
Cover natural polymer biomaterial chitosan coat towards the net wall of internal organs, be to be coated on net wall, and finalize the design in 40 ℃ of baking oven inner dryings towards internal organs with 2.0% chitosan coat agent; Repeat aforesaid operations 2-3 time.
Good effect behind enforcement this utility model is:
Play and prevent paradoxical breathing, keep the thoracic wall Stabilization in early days,, play the effect of promotion tissue growth simultaneously as organization bracket; Later stage finally for autologous tissue replaces, is finished body self reparation along with progressively degraded and absorbed is repaired by body autologous tissue, and the long term complication of having avoided traditional material to bring.
Description of drawings
Fig. 1, artificial breast wall planar structure sketch map;
Fig. 2, coating not, artificial breast wall vertical profile sketch map;
After Fig. 3, the coating (mesh clearance seal), artificial breast wall vertical profile sketch map.
The specific embodiment
Now the utility model is described in further detail in conjunction with the accompanying drawings
Biodegradable reticular artificial chest wall is woven into the thoracic wall form to be repaired of porous network structure by polydioxanone monofilament fiber 1; By collagen protein 2 uniformly penetratings, topped, sealing mesh; And by the net wall of the even coverage of natural polymer biomaterial chitosan to internal organs.
The preparation method of Biodegradable reticular artificial chest wall, operation according to the following steps, finish the preparation of artificial breast wall:
1) adopts the plain woven method, the network of the thoracic wall form that braiding polydioxanone monofilament one-tenth is to be repaired;
2) with network on JX-826 electric heating hydraulic molding machine, hot pressing setting;
3) network of setting is done collagen protein covering surfaces and the processing of sealing mesh;
4) the net wall towards internal organs covers natural polymer biomaterial chitosan coat;
5) standby after sterilization, the dried.
The woven mesh support, its parameter is as follows: fibre diameter: 0.28mm, end count: 320/10cm, filling density: 230/10cm, the warp-wise tightness: 89.6%, broadwise tightness: 64.4%; The hot pressing setting is at temperature 85-95 ℃, formalizes 5-10 second.Doing topped surface of collagen protein and the processing of sealing mesh, is network to be dipped in 2% collagen solution take out after 3 minutes, is placed on 40 ℃ of baking oven inner dryings, repeats aforesaid operations 2-3 time; Towards the topped natural polymer biomaterial of the net wall chitosan coat of internal organs, be to be coated on net wall towards internal organs with 2.0% chitosan coat agent, and in 40 ℃ of baking oven inner dryings typings; Repeat aforesaid operations 2-3 time;
Embodiment
The polydioxanone monofilament fiber is (fibre diameter: 0.28mm under the certain parameter condition, end count: 320/10cm, filling density: 230/10cm, warp-wise tightness: 89.6%, broadwise tightness: 64.4%) be woven into net, make this network material possess good tensile and structural stability, have certain bending rigidity through the plain woven method, thickness 0.8mm, mesh gap 200～300 μ m; With its hot pressing setting (90 ℃ of temperature) 5 seconds on JX-826 electric heating hydraulic molding machine, be cut into 8cm * 8cm size; Then it is dipped in 2% collagen solution and takes out behind the 3min, be placed on baking oven inner drying (40 ℃), make collagen protein seal netted material hole crack, repeat aforesaid operations 2 times; Adopt 2.0% chitosan coat agent to be coated on artificial breast wall material inboard (dirty side), be placed on (40 ℃) dryness finalization in the baking oven, take out dry back, repeats aforesaid operations 2 times; The dry sealing of the final vacuum of artificial breast wall ethane via epoxyethane sterilization then is as for preserving under 4 ℃ of conditions.
Select endotracheal intubation behind the healthy hybrid dog general intravenous anesthesia, mechanical ventilation, one section in en bloc resection dog right side thoracic wall six, seven, eight ribs, form 8cm * 8cm size chest wall defect, with silk thread Biodegradable reticular artificial chest wall and damaged surrounding tissue are sewed up, upper and lower costal margin and tissue are striden intercostal holostrome interrupted suture, note keeping net non-wrinkled, stitching finishes and forms certain tension force, close breast after placing closed thoracic drainage tube, connect thoracic cavity drainage bottle, material and flesh interlayer are kept somewhere the negative pressure ball drain, close otch behind the stitching thoracic wall shallow-layer muscle.
Embodiment result:
The postoperative dog is movable normal, the apnea difficulty.There is slight abnormal breathing in early stage observation small part dog, weakens gradually, disappears in 3～4 all paradoxical breathings; Postoperative 8 during week palpation show that damaged reconstruction position thoracic wall fixes, to 24 weeks of postoperative, the thoracic wall good stability, profile is satisfied.Postoperative is regularly put to death experimental dog, sees a large amount of fibrous tissue PDO mesh gap of growing into 8 weeks, merges with timbering material and forms integrative-structure, combines closely with surrounding tissue, and it is stable that thoracic wall keeps, and it is good that the reticular artificial chest wall structure keeps; The artificial breast wall material begins obvious degradation absorption minimizing during 12 weeks, is progressively replaced by regeneration thoracic wall tissue, and regenerating tissues is made up of volume fibroblast, new vessels and collagen fiber, a small amount of therebetween chronic inflammation cellular infiltration; To 24 weeks of postoperative, the complete degraded and absorbed of implantable artificial thoracic wall material is replaced by a thick fiber organized layer.
Claims (1)
1, Biodegradable reticular artificial chest wall comprises the artificial breast wall of structure, it is characterized in that: be made of the porous rack that matches with thoracic wall form to be repaired polydioxanone monofilament fiber (1); Mesh and rack surface uniformly penetrating, covering one deck collagen protein (2); And evenly cover one deck natural polymer biomaterial chitosan at net wall surface towards internal organs.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200620044851 CN200963204Y (en) | 2006-08-16 | 2006-08-16 | Biological degradable netted artificial chest wall |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200620044851 CN200963204Y (en) | 2006-08-16 | 2006-08-16 | Biological degradable netted artificial chest wall |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN200963204Y true CN200963204Y (en) | 2007-10-24 |
Family
ID=38867213
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200620044851 Expired - Fee Related CN200963204Y (en) | 2006-08-16 | 2006-08-16 | Biological degradable netted artificial chest wall |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN200963204Y (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100441238C (en) * | 2006-08-16 | 2008-12-10 | 徐志飞 | Biodegradable reticular artificial chest wall and preparation method thereof |
| CN101548916B (en) * | 2009-05-08 | 2012-10-10 | 乐普（北京）医疗器械股份有限公司 | A medical equipment carrying extracellular matrix and its production method |
| CN111821064A (en) * | 2015-11-04 | 2020-10-27 | 聚合-医药有限公司 | Time-dependent tissue scaffolds |
-
2006
- 2006-08-16 CN CN 200620044851 patent/CN200963204Y/en not_active Expired - Fee Related
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100441238C (en) * | 2006-08-16 | 2008-12-10 | 徐志飞 | Biodegradable reticular artificial chest wall and preparation method thereof |
| CN101548916B (en) * | 2009-05-08 | 2012-10-10 | 乐普（北京）医疗器械股份有限公司 | A medical equipment carrying extracellular matrix and its production method |
| CN111821064A (en) * | 2015-11-04 | 2020-10-27 | 聚合-医药有限公司 | Time-dependent tissue scaffolds |
| CN111821064B (en) * | 2015-11-04 | 2023-10-31 | 聚合-医药有限公司 | time-dependent physiological tissue scaffold |
| US12290430B2 (en) | 2015-11-04 | 2025-05-06 | Poly-Med, Inc. | Time dependent physiologic tissue scaffold |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Du et al. | Biomimetic neural scaffolds: a crucial step towards optimal peripheral nerve regeneration | |
| TWI229113B (en) | Collagen material and its production process | |
| EP3404133B1 (en) | Warp-knitted fabric and medical material | |
| US20110035023A1 (en) | Prosthesis for promoting the in vivo reconstruction of a hollow organ or a portion of a hollow organ | |
| JP5142219B2 (en) | Thin film multituft structure made of collagen, tissue regeneration member containing the same, and method for producing them | |
| CN1237913A (en) | Collagen material and preparation method thereof | |
| EP2921136A1 (en) | Fiber membranes for repairing tissue and products and preparation method thereof | |
| WO2017148255A1 (en) | Composite soft tissue repairing material for stabilizing repair region | |
| CN109701080A (en) | 4 axis 3D printing tubular medical brackets of one kind and preparation method thereof | |
| JP2010535052A (en) | Bioabsorbable implant | |
| JP4968976B2 (en) | Collagen material and production method thereof | |
| EP2863838B1 (en) | Compression and kink resistant implants | |
| CN100441238C (en) | Biodegradable reticular artificial chest wall and preparation method thereof | |
| CN100531808C (en) | Degradable Soft Tissue Patches | |
| CN106237389A (en) | A kind of composite artificial blood vessel | |
| CN102895702A (en) | Composite artificial bile duct and preparation method thereof | |
| CN200963204Y (en) | Biological degradable netted artificial chest wall | |
| JP3970013B2 (en) | Lumen formation inducing material and intracorporeal instrument | |
| US8496714B2 (en) | Base material for revascularization | |
| CN111714707A (en) | Anti-infection anti-adhesion composite hernia repair patch and preparation method thereof | |
| CN115607730B (en) | Degradable bionic artificial trachea | |
| CN213372741U (en) | Novel hernia repair patch | |
| CN104188734B (en) | The spherical artificial urinary bladder of a kind of degradable | |
| JPH07299084A (en) | Artificial prosthesis | |
| US12544205B2 (en) | Warp-knitted fabric and medical material |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C17 | Cessation of patent right | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20071024 Termination date: 20110816 |