CN2085668U - Pulse controllable syringe system for insuline - Google Patents
Pulse controllable syringe system for insuline Download PDFInfo
- Publication number
- CN2085668U CN2085668U CN 90218888 CN90218888U CN2085668U CN 2085668 U CN2085668 U CN 2085668U CN 90218888 CN90218888 CN 90218888 CN 90218888 U CN90218888 U CN 90218888U CN 2085668 U CN2085668 U CN 2085668U
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- CN
- China
- Prior art keywords
- pulse
- insulin
- control circuit
- syringe system
- automatic control
- Prior art date
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- 239000007788 liquid Substances 0.000 claims abstract description 8
- 239000003814 drug Substances 0.000 claims abstract description 6
- 235000012054 meals Nutrition 0.000 claims description 9
- 239000000853 adhesive Substances 0.000 claims description 3
- 230000001070 adhesive effect Effects 0.000 claims description 3
- 229940079593 drug Drugs 0.000 claims description 3
- 239000004816 latex Substances 0.000 claims description 3
- 229920000126 latex Polymers 0.000 claims description 3
- 238000000520 microinjection Methods 0.000 claims 1
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 abstract description 25
- 229940125396 insulin Drugs 0.000 abstract description 13
- 102000004877 Insulin Human genes 0.000 abstract description 12
- 108090001061 Insulin Proteins 0.000 abstract description 12
- 238000002347 injection Methods 0.000 abstract description 10
- 239000007924 injection Substances 0.000 abstract description 10
- 201000010099 disease Diseases 0.000 abstract description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract description 2
- 206010012601 diabetes mellitus Diseases 0.000 description 6
- 238000007920 subcutaneous administration Methods 0.000 description 4
- 230000003914 insulin secretion Effects 0.000 description 3
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 2
- 101000976075 Homo sapiens Insulin Proteins 0.000 description 2
- 210000000227 basophil cell of anterior lobe of hypophysis Anatomy 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 239000008103 glucose Substances 0.000 description 2
- PBGKTOXHQIOBKM-FHFVDXKLSA-N insulin (human) Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@H]1CSSC[C@H]2C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3C=CC(O)=CC=3)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3NC=NC=3)NC(=O)[C@H](CO)NC(=O)CNC1=O)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(=O)N[C@@H](CC(N)=O)C(O)=O)=O)CSSC[C@@H](C(N2)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)CN)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)CC=1C=CC=CC=1)C(C)C)C1=CN=CN1 PBGKTOXHQIOBKM-FHFVDXKLSA-N 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 238000010254 subcutaneous injection Methods 0.000 description 2
- 239000007929 subcutaneous injection Substances 0.000 description 2
- 208000001072 type 2 diabetes mellitus Diseases 0.000 description 2
- 101001005269 Arabidopsis thaliana Ceramide synthase 1 LOH3 Proteins 0.000 description 1
- 101001005312 Arabidopsis thaliana Ceramide synthase LOH1 Proteins 0.000 description 1
- 101001089091 Cytisus scoparius 2-acetamido-2-deoxy-D-galactose-binding seed lectin 2 Proteins 0.000 description 1
- 208000013016 Hypoglycemia Diseases 0.000 description 1
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000007599 discharging Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000004134 energy conservation Methods 0.000 description 1
- 208000004104 gestational diabetes Diseases 0.000 description 1
- 230000002218 hypoglycaemic effect Effects 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 230000010355 oscillation Effects 0.000 description 1
- 230000035479 physiological effects, processes and functions Effects 0.000 description 1
- 230000035935 pregnancy Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 210000000707 wrist Anatomy 0.000 description 1
Images
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- Infusion, Injection, And Reservoir Apparatuses (AREA)
Abstract
The utility model relates to a pulse controllable syringe system for insulin, belonging to a medical automatic syringe. The electromagnetic performer is controlled by a pulse control circuit to squeeze the transfusion tube, a check valve is adopted to make to medicine liquid unidirectional flow, and thus a micro and continuous syringe system is formed. The pulse signals can be automatically given out by the automatic control circuit according to a designed program and frequency. A start button used for adding dose is added, and the acoustic and light working indicating is safe. The pulse controllable syringe system for insulin can realize a continuous and fully automatical medicine supply with small dose, is miniature, the wearing is convenient, and is suitable for the injection treatment of various diseases.
Description
This utility model relates to medical automatic injector.
China's onset diabetes rate is 1%, estimate that diabetics has about 10,000,000 approximately, wherein have half people to need continuously approximately or be interrupted and use insulin, but because of the quality and the injecting method of insulin not good, the use face of insulin dwindles greatly, causes a large amount of patients to be disabled or death.The progress key of injection of insulin method, one is low dose of successive administration, two are to simulate human insulin β cells physiological insulin secretion curve.Continuous injection all gives attention highly to insulin in the world.As Japanese CSII system (Continuous Subcutaneous Insuline Injection System) and Clossed System, adopt blood glucose to detect in real time, by the computer realization closed loop control, make the insulin administration amount adapt to the changes of blood glucose situation at any time.But this system is too complicated and expensive, is not easy to large-scale popularization and uses.The adjustable automatic injector of YZD-I of domestic Zhenjiang development supplies Teat pipette by micro motor for driving, and scalable administration injection frequency, but all can not adapt to the requirement that insulin is injected low dose continuously for dose and control accuracy, single injection dosage is more than ten times of cushion still, adjust the requirement of dosage in the time of particularly can not simulating physiology insulin secretion curve and dining.
The purpose of this utility model provide a kind of can the continuous small dose administration, and can simulate human insulin β cells physiological insulin secretion curve and adjust the controlled insulin-injecting system of pulse of the requirement of dosage when having meal.This system bulk is little, is easy to carry.
Main points of the present utility model are to adopt pulse control circuit, the control electromagnetic actuator is squeezed grug transportation tube, and utilize two check-valves to make the medicinal liquid one-way flow, electric pulse of the every acceptance of electromagnetic actuator just provides a fixed small dose, and automatic control circuit can provide electric impulse signal according to program and the Automatic Frequency set.Artificial pressing dining button during dining, control circuit promptly converts " the dining frequency " of setting to, and (for example 20 minutes) control circuit restores automatically after after a while, returns to the frequency maintenance dose of former setting.For preventing instrument failure and patient carelessness, control circuit is provided with acousto-optic work indication and reports to the police.The additional dosage of having meal can be set up by doctor's advice.
Fig. 1 is the controlled insulin-injecting system automatic control circuit of a pulse schematic diagram.Fig. 2 is the controlled insulin-injecting system structural representation of pulse.Square frame 1-vibration, frequency divider among Fig. 1, the 2-pulse-width controller, the 3-trigger, the 4-agitator, the 5-pulse width modulation, the 6-power amplifier, 7-sound, light work indication, 8-has meal and adds the dose starting button, and the additional dose of 9-dining is regulated.11-automatic control circuit among Fig. 2,12-lead, 13-electromagnetic actuator, 14-drug storage bottle, 15-insulin, 16-latex tubing, 17, the 18-check-valves, 19-syringe needle.
The controlled insulin-injecting system of contrast accompanying drawing paired pulses further specifies below.Vibration, frequency divider 1 produce a built-in oscillation frequency, and carry out frequency division make it to produce be fit to insulin continuously injection the interval and have meal preset time.Agitator 4, trigger 3 are need increase administration frequency for solving when having meal, and 8 are the additional administration starting button of having meal.Pulse-width controller 2 is with pulse width modulation 5 restrictions and set pulse width, amplify rear drive electromagnetic actuator 13 by power amplifier 6, sound, light work indication 7 are for safety monitoring and warning, notice to cause the patient whether instrument work normally prevents from fault or have a dinner to forget and press the dining button.After pulse frequency and treatment sequence setting, automatic control circuit 11 is by given frequency and program output electric pulse, and each pulse is oppressed newborn vascular 16 by driving electromagnetic actuator 13 adhesives once during the electromagnetic valve adhesive, a certain amount of medicinal liquid is forced out pipeline, and 19 injection patients are subcutaneous by syringe needle.Pair of check valves 17,18 can only flow medicinal liquid by the direction of arrow of setting, make the medicinal liquid one-way flow can utilize the thin latex tubing of garden type (or the end has sphere), in end spherical cut or pipe side cutout, form unidirectional non-return effect by pipe inside and outside wall liquid body pressure, use in pairs and form continuously injecting systems automatically.The vacuum that medicinal liquid 15 forms when discharging by electromagnetic valve is replenished automatically from drug storage bottle 14.Syringe needle 19 is embedded in the subcutaneous of patient's arm, forms full-automatic continuous subcutaneous injection.Artificial pressing dining button can be accelerated administration frequency by set-point during dining, the needs of meal island element when having meal to adapt to.
Pulse controllable syringe system for insuline has significant advantage: miniature, be easy to carry, be worn on wrist such as wrist-watch; Energy-conservation, the miniature rechargeable battery of 3.8V, charging in 7-10 days is once; Convenient, full-automatic continuous subcutaneous injection can simulate physiological amount and release profiles; Effective, the low dose of continuous release of insulin makes it subcutaneous abundant
Overflow, result for the treatment of is better than heavy dose of fractional injection, and has greatly dwindled the use amount of insulin, has avoided the reaction of medicine source and the complication such as hypoglycemia Somegy reaction and kidney damage. Pulse controllable syringe system for insuline adapts to the injection for curing of various disease conditions, I type (IDDM) diabetes for example, severe II type (NIDDM) diabetes, delay into the type diabetes, the type II diabetes of serious complication is arranged, gestational diabetes mellitus, Diabetic Pregnancy, dystrophic diabetes etc. Thereby pulse controllable syringe system for insuline is a kind of of many uses, wears conveniently the therapeutic equipments of safe and reliable science.
Claims (4)
1, the controlled insulin-injecting system of pulse, form by automatic control circuit [11], drug storage bottle [14] and syringe needle [19], it is characterized in that grug transportation tube [16] being squeezed, and utilize check-valves [17], [18] to make the medicinal liquid one-way flow inject patient's full-automatic micro-injection system continuously through syringe needle by the adhesive of automatic control circuit [11] control electromagnetic actuator [13].
2,, it is characterized in that said control circuit (11) is provided with the additional dose of the dining of adjusting the dining dosage and regulates (9) and have meal additional dose starting button (8) according to the said pulse insulin-injecting system of claim 1.
3,, it is characterized in that said automatic control circuit is provided with the sound of security alarm, light work indication (7) according to claim 1 and the controlled insulin-injecting system of 2 said pulses.
4, according to claim 1 and the controlled insulin-injecting system of 2 said pulses, it is characterized in that said check-valves (17), (18) can be the thin latex tubings of the garden type (or end dribbling face) that uses in pairs, constitute in end spherical cut or pipe side cutout.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 90218888 CN2085668U (en) | 1990-09-05 | 1990-09-05 | Pulse controllable syringe system for insuline |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 90218888 CN2085668U (en) | 1990-09-05 | 1990-09-05 | Pulse controllable syringe system for insuline |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN2085668U true CN2085668U (en) | 1991-10-02 |
Family
ID=4897636
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 90218888 Withdrawn CN2085668U (en) | 1990-09-05 | 1990-09-05 | Pulse controllable syringe system for insuline |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN2085668U (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1325127C (en) * | 2000-12-22 | 2007-07-11 | Dca设计国际有限公司 | Drive mechanism for an injection device |
| CN102000372A (en) * | 2010-12-09 | 2011-04-06 | 江苏华阳电器有限公司 | Intelligent insulin pump system |
| CN102648470A (en) * | 2009-11-17 | 2012-08-22 | 霍夫曼-拉罗奇有限公司 | Hypoglycemic treatment systems |
-
1990
- 1990-09-05 CN CN 90218888 patent/CN2085668U/en not_active Withdrawn
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1325127C (en) * | 2000-12-22 | 2007-07-11 | Dca设计国际有限公司 | Drive mechanism for an injection device |
| CN102648470A (en) * | 2009-11-17 | 2012-08-22 | 霍夫曼-拉罗奇有限公司 | Hypoglycemic treatment systems |
| CN102000372A (en) * | 2010-12-09 | 2011-04-06 | 江苏华阳电器有限公司 | Intelligent insulin pump system |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C15 | Extension of patent right duration from 15 to 20 years for appl. with date before 31.12.1992 and still valid on 11.12.2001 (patent law change 1993) | ||
| RN01 | Renewal of patent term | ||
| C19 | Lapse of patent right due to non-payment of the annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |