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CN207193277U - A kind of cell collection device - Google Patents

A kind of cell collection device Download PDF

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Publication number
CN207193277U
CN207193277U CN201721156949.6U CN201721156949U CN207193277U CN 207193277 U CN207193277 U CN 207193277U CN 201721156949 U CN201721156949 U CN 201721156949U CN 207193277 U CN207193277 U CN 207193277U
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collecting pipe
centrifugation
wall
main body
collection device
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申大伟
叶锋
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Beijing Jingzhun Medical Technology Co Ltd
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Beijing Jingzhun Medical Technology Co Ltd
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Abstract

The utility model is a kind of cell collection device, including centrifugation pipe cap, centrifugation body, collecting pipe main body and collecting pipe filter window;Centrifugation body is provided with centrifuge tube external screw thread and centrifuge tube internal thread;The upper end of collecting pipe main body is provided with collecting pipe edge;Collecting pipe main body is placed in centrifuge tube body, collecting pipe edge is set to be arranged at the upper end of centrifugation body, collecting pipe main body is fixedly connected by centrifuge tube internal thread with centrifugation body, centrifugation pipe cap is fixedly connected by centrifuge tube external screw thread with centrifugation body, collecting pipe edge is set to be placed in centrifugation pipe cap, and centrifugation pipe cap, collecting pipe edge and centrifugation body is combined closely, reach sealing state;The lower end of collecting pipe main body is connected with the upper end of collecting pipe filter window.It is no in the prior art the utility model has the advantage of the click-on design of bottom and the design of bottom buckle closure, the design is easy to the cell mass of shaping to take out, the step of being rolled into a ball with hard thing ejection constitutive cell is eliminated compared to traditional mode, improves experiment success rate and conventional efficient.

Description

A kind of cell collection device
Technical field
Field of medical device is the utility model is related to, is a kind of device being used for from biological specimen collection cell, is specifically A kind of cell collection device.
Background technology
One of forward position of current early diagnosis of cancer and monitoring development is how to be entered using blood, urine or other body fluid Row cancer diagnosis and examination.The maximum advantage of the technology is:Noninvasive detects, and early stage efficient diagnosis cancer can occur in cancer Disease and can Reusability in a short time, so as to realize immediately monitoring.In addition, it avoids patient from receiving unnecessary live body inspection Look into, testing cost is also relatively cheap, is advantageous to extensive use clinically.With the development of science and technology, this is detected in recent years The degree of accuracy and sensitivity of technology have greatly improved.But how extremely micro cancer cell from a large amount of body fluid it is easy, Quickly separating is current research person endeavours the problem of to be solved.
In the past cell was collected using the method for traditional centrifugation.The cell that need to be collected is put into test tube, it is conventional from The heart, but find some shortcomings through long-term clinical practice:Concentrated reflection is after test tube centrifugation, the when of falling supernatant, once not Totally, need to take back and forth.Such result causes the cell being fully enriched with after centrifugation, in taking repeatedly Cheng Zhong, and be mutually mixed with remaining liquid (because supernatant is by manual operation, it is impossible to fall very clean), and make through centrifugation The cell of concentration is watered down once again.Supernatant is removed every time, can all lose cell, the cell quantity for causing to finally give subtracts significantly It is few, sample validity and positive clinical rate are reduced, and greatly increase the working strength of experimenter.Moreover, this method without Method separates different types of cell.
In view of this, a kind of appearance of cell harvestor easy to operate, reducing labor intensity is with regard to necessary.
In order to analyze cell, it is often necessary to separate and collect cell from biological specimen.For example, in order to diagnose And/or treatment some diseases, it may be necessary to so do.For example, the analysis of the cell extracted from urine specimen can be used for diagnosing Carcinoma of urinary bladder, or the cell separated from excrement can be used for the cancer of diagnosis intestines and stomach.
Conventional is that cell is collected from fluid sample using centrifugal force, and the power that wherein high speed centrifugation power is applied causes sample Larger, thicker particle is settled out in this.Typically, larger particle includes the cell material being included in sample, and it is Separated with the fluid composition of sample.Once cell material has obtained, then can using microscope or other analysis methods come pair It is analyzed.
During centrifugal treating, biological specimen and the cell material being included in are subjected to significant forces.These power can be led Cause the damage of cell material, such as cell rupture.This can influence obtained result, and/or cause when the extracted material of analysis It is difficult to complete diagnosis during material.
Further, since the needs to special equipment, it is often necessary to which biological specimen is sent to remote laboratory so as to reality Apply centrifugation and analysis.Cell material in biological specimen is degraded with the time, is obtained between sample and analysis sample Any delay can cause analyzed material to become to damage.This can influence obtained result, and/or make it difficult to make diagnosis. Therefore, for using needing sample being sent to remote laboratory to carry out the necessity of the special equipment of point analysis of variance It is undesirable, because delay is imported into the process, therefore increases the risk that extracted cell degenerates.
Therefore, accurately diagnosed to optimize the quality of extracted cell material and can make, it is necessary to which a kind of minimize The method that cell is collected from fluid sample of damage is caused to cell.
Pleural effusion is common clinical, and the common cause of disease has a lot, such as cardiovascular disease, hepatopathy, peritoneopathy, kidney Disease, dystrophia disease, the transfer of malignant tumour peritonaeum, ovarian neoplasm, connective tissue disease etc., disease form pleural effusion and are excessively As Pleural effusions.Pleural effusions inspection be used clinically for by check the property of Pleural effusions determine Pleural effusions formation the reason for and The cause of disease, the treatment to clinical disease play directiveness.
Pernicious Pleural effusions refer to because the malignant tumour or cancerous lesion that occur in whole body or splanchnocoel cause thoracic cavity, abdominal cavity Lamina visceralis pleuroperitoneum occurs diffusivity lesion and causes the phenomenon of cavity fluids abnormal increase, therefore clinically in the chest and abdomen of extraction Cancer cell is found in water to be to patient's progress cause of disease determination and takes the premise effectively treated in time.Generally Pleural effusions are big Thousands of milliliters are there are about, and clinically often outwards extract 5~10ml Pleural effusions censorship at random with drainage tube;However, due to In initial stage of cancer, cancer cell number is less, therefore occurs and fail to pinpoint a disease in diagnosis phenomenon, so that delay conditions of patients.
Prior art is as follows:Notification number CN204874521U, patent " cell collection device " is disclosed, it passed through The form of filter device and piston pressurization realizes that cell is collected.
Notification number CN205019489U, patent " exfoliated tumor cells absorptive collection device " is disclosed, is produced by motor Raw vacuum suction to liquid passes through adsorbent, reaches the collecting action of cell.
Notification number CN204939464U discloses patent " cell separation collector " centrifugal device distal end and in centrifugation masterpiece The waste liquid chamber that is passed through with collecting chamber, the waste liquid for isolating of lower collection target cell, it is arranged between collecting chamber and waste liquid chamber And target cell is blocked in collecting chamber and the waste liquid of separation is passed through the filter membrane of waste liquid chamber;It is provided with collecting chamber Enter the inlet of collecting chamber for cell suspending liquid, the liquid outlet for discharging the waste liquid of separation is provided with waste liquid chamber;Filter membrane The diameter of filter opening is less than the diameter of target cell.
Notification number CN203754716U, patent " a kind of cell splitter and separator " is disclosed, separated comprising cell Post cylinder, separation cylinder are hollow cylinder, and lower section is detachably provided with for the upper strata filter membrane for isolating and purifying spermatid nucleus with Layer filter membrane, the filter opening aperture of upper strata filter membrane are more than the filter opening aperture of lower floor's filter membrane, and cell splitter is removably mounted to waste liquid receipts Splitter bayonet socket is included in collector, inside waste collection pipe, also includes air guide groove on bayonet socket, air guide groove is by waste collection pipe Inside connects with extraneous air.
Notification number CN105358957A, disclose patent " cell collection device ", in fluid flowing path, when first chamber and When second chamber is connected to each other, perforated membrane sorption is between first chamber and second chamber.Absorber is positioned near porous The downstream surface of film, elastomeric element are arranged towards perforated membrane extruding absorber.When in use, it is imported into the sample of first chamber The upstream face of perforated membrane is contacted, fluid is drawn through perforated membrane and absorbed by absorber.The cell being present in sample is protected Hold on the upstream face of perforated membrane.First chamber and second chamber separation after, perforated membrane can from device remove with Just the cell of deposition is analyzed.
Notification number CN203846026U, patent " a kind of collection device of circulating tumor cell " is disclosed, is set in screen pipe There is horizontally disposed grid, grid is provided with the filter membrane of average pore size, for fixing the press mold ring of filter membrane;Aid in chimney filter, the set Bore is more than the lower outer diameter of screen pipe.
Notification number CN205313537U, disclose " circulating tumor cell collection device ", including auxiliary chimney filter, screen pipe and Collet, auxiliary chimney filter includes the connecting portion being in the form of a column and the assisted parts being connected with one end of connecting portion, the diameter of assisted parts are more than The diameter of connecting portion;Screen pipe is in hollow column, and connecting portion can be inserted into one end of screen pipe, and the accommodated inside of screen pipe has one Filter membrane;Collet includes cylindrical chassis and columned stud, and stud is located at the side on chassis, and the diameter on chassis is more than support The diameter of post, stud can be inserted into the other end of screen pipe, and chassis, which is provided with, is easy to the hole that liquid passes through.
Notification number CN205258443U, disclose patent " rare cell enriching apparatus ", cell screening part, included in two Individual cell screening passage, at least one surface are magnetic absorption surface, and the thickness of cell screening passage is arranged to 0.1 millimeter to 5 Millimeter;Filter element, the downstream of cell screening part is removable installed in, to retain not by the rare cell of magnetic absorption.
Notification number 205974525U, disclose patent " a kind of cell-enriching device ", including vibrations version, support, specimen cup. Upper lid, inflation inlet, upper clamping sleeve, upper microporous barrier, lower clamping sleeve, lower microporous barrier and waste collection bottle.
Publication No. CN105331516A, patent " rare cell enriching apparatus and method " is disclosed, comprising formation at two Cell screening passage between apparent surface, at least one surface in two apparent surfaces is magnetic absorption surface, wherein carefully The thickness of born of the same parents' screening passage is arranged to, and cell is formed so that when cell suspension flows through substantially with the thin liquid of monolayer distribution Layer, when being adsorbed to the magnetic absorption surface in the cell screening passage so as to combine most cells of biomolecular Avoid sweeping along rare cell.
Utility model content
Present the utility model has devised a kind of cell collection device, overcome or substantially alleviate with it is existing The relevant above mentioned problem of technology and/or other problemses.
To achieve the above objectives, the utility model adopts the technical scheme that:
A kind of cell collection device, including:Centrifuge pipe cap 1, centrifugation body 7, collecting pipe main body 5 and collecting pipe filter window 8;
The centrifugation body 7 is provided with centrifuge tube external screw thread 3 and centrifuge tube internal thread 4;
The upper end of the collecting pipe main body 5 is provided with collecting pipe edge 2;
The collecting pipe main body 5 is placed in centrifugation body 7, collecting pipe edge 2 is arranged at the upper end of centrifugation body 7, is received Header body 5 by centrifuge tube internal thread 4 with centrifugation body 7 be fixedly connected, centrifugation pipe cap 1 by centrifuge tube external screw thread 3 with from Heart body 7 is fixedly connected, and collecting pipe edge 2 is placed in centrifugation pipe cap 1, and makes centrifugation pipe cap 1, collecting pipe edge 2 and centrifugation Body 7 is combined closely, and reaches sealing state;
The lower end of the collecting pipe main body 5 is connected with the upper end of collecting pipe filter window 8.
On the basis of such scheme, the collecting pipe filter window 8 is double-skin duct, and duct wall is provided with multiple openings, shape Into multiple small windows;Milipore filter is provided with the space of the double-skin duct.
On the basis of such scheme, window wall 12, the collecting pipe are filtered in the outer surface of the collecting pipe filter window 8 for collecting pipe Filter window wall 12 includes:Wall 121 and collecting pipe filter window inwall 122, collecting pipe are filtered wall 121 outside window and filtered with collecting pipe outside window for collecting pipe filter Milipore filter is provided between window inwall 122.
On the basis of such scheme, the lower end of the collecting pipe filter window 8 is provided with bottom buckle closure 9, the left side of bottom buckle closure 9 Upper end and collecting pipe filter window wall 12 is fixedly connected, and the right side upper end of bottom buckle closure 9 is hollow buckle 11 provided with centre, collecting pipe The right side lower end of filter window wall 12 is provided with buckle closure excrescence 10, and buckle closure excrescence 10 is flexibly connected to form close buckle with buckle 11 Cynapse composite, for fixing the right side upper end of bottom buckle closure 9;The lower end of the bottom buckle closure 9 is hanging;
Milipore filter is provided with the internal voids of the bottom buckle closure 9.
On the basis of such scheme, the diameter of the milipore filter is between 0.22-0.45 microns.
On the basis of such scheme, the outer wall of collecting pipe main body 5 is collecting pipe main wall 6, under collecting pipe main wall 6 The upper end with collecting pipe filter window wall 12 is held to be connected.
On the basis of such scheme, the outer wall of the centrifugation body 7 is centrifuge tube main wall 13.
On the basis of such scheme, the centrifugation that the cell collection device uses is horizontal centrifugal, with 1000- 3000rpm/min rotating speeds, centrifuge 5 minutes.
The utility model has the advantage of:
1st, purifying cells can be efficiently separated and the damage very little to cell;
2nd, unique detachable filter membrane fixing device, the subsequent treatment of convenience sample;
3rd, exclusive double layer sandwich is separated by filtration design, efficiently separates cell, prevents from separating not thorough because being blocked;
4th, filtering type, which designs, make it that loss cell is less in sample, is adapted to the needs of different experiments;
5th, the click-on design of bottom and the design of bottom buckle closure are unexistent in the prior art, and the thin of shaping is easy in the design Born of the same parents group take out, compared to traditional mode eliminate with hard thing ejection shaping cell mass the step of, improve experiment success rate with Conventional efficient;
6th, detachable filter membrane fixing device can easily take out the cell mass of shaping, because milipore filter is in tweezers and collection Pipe filter window wall takes out in the presence of gap, will not have an impact to the constitutive cell group of inside, can promote its taking-up on the contrary.
Brief description of the drawings
The utility model has drawings described below:
Fig. 1 is the front view of the utility model cell collection device;
Fig. 2 is the zoomed-in view of collecting pipe main body in Fig. 1;
Fig. 3 is the planar representation of collecting pipe filter window in Fig. 1;
Fig. 4 is the top view of collecting pipe filter window in Fig. 1;
Label declaration in accompanying drawing:
1st, pipe cap is centrifuged;2nd, collecting pipe edge;3rd, centrifuge tube external screw thread;4th, centrifuge tube internal thread;5th, collecting pipe main body;6、 Collecting pipe main wall;7th, body is centrifuged;8th, collecting pipe filter window;9th, bottom buckle closure;10th, buckle closure excrescence;11st, buckle;12nd, collect Pipe filters window wall;13rd, centrifuge tube main wall;121st, collecting pipe filters wall outside window;122nd, collecting pipe filter window inwall.
Embodiment
The utility model is described in further detail below in conjunction with accompanying drawing 1-4.
According to the technical solution of the utility model, there is provided a kind of cell collection device, the volume of device is 15ml, to be received Collect 500ml liver ascites cells, described device includes:
Centrifuge pipe cap 1, centrifugation body 7, collecting pipe main body 5 and collecting pipe filter window 8;
The centrifugation body 7 is provided with centrifuge tube external screw thread 3 and centrifuge tube internal thread 4;
The upper end of the collecting pipe main body 5 is provided with collecting pipe edge 2;
The collecting pipe main body 5 is placed in centrifugation body 7, collecting pipe edge 2 is arranged at the upper end of centrifugation body 7, is received Header body 5 by centrifuge tube internal thread 4 with centrifugation body 7 be fixedly connected, centrifugation pipe cap 1 by centrifuge tube external screw thread 3 with from Heart body 7 is fixedly connected, and collecting pipe edge 2 is placed in centrifugation pipe cap 1, and makes centrifugation pipe cap 1, collecting pipe edge 2 and centrifugation Body 7 is combined closely, and reaches sealing state;
The lower end of the collecting pipe main body 5 is connected with the upper end of collecting pipe filter window 8.
On the basis of such scheme, the collecting pipe filter window 8 is double-skin duct, and duct wall is provided with multiple openings, shape Into multiple small windows;Milipore filter is provided with the space of the double-skin duct.
On the basis of such scheme, window wall 12, the collecting pipe are filtered in the outer surface of the collecting pipe filter window 8 for collecting pipe Filter window wall 12 includes:Wall 121 and collecting pipe filter window inwall 122, collecting pipe are filtered wall 121 outside window and filtered with collecting pipe outside window for collecting pipe filter Milipore filter is provided between window inwall 122.
On the basis of such scheme, the lower end of the collecting pipe filter window 8 is provided with bottom buckle closure 9, the left side of bottom buckle closure 9 Upper end and collecting pipe filter window wall 12 is fixedly connected, and the right side upper end of bottom buckle closure 9 is hollow buckle 11 provided with centre, collecting pipe The right side lower end of filter window wall 12 is provided with buckle closure excrescence 10, and buckle closure excrescence 10 is flexibly connected to form close buckle with buckle 11 Cynapse composite, for fixing the right side upper end of bottom buckle closure 9;The lower end of the bottom buckle closure 9 is hanging;
Milipore filter is provided with the internal voids of the bottom buckle closure 9.
On the basis of such scheme, the diameter of the milipore filter is between 0.22-0.45 microns.
On the basis of such scheme, the outer wall of collecting pipe main body 5 is collecting pipe main wall 6, under collecting pipe main wall 6 The upper end with collecting pipe filter window wall 12 is held to be connected.
On the basis of such scheme, the outer wall of the centrifugation body 7 is centrifuge tube main wall 13.
On the basis of such scheme, the centrifugation that the cell collection device uses is horizontal centrifugal, with 1000- 3000rpm/min rotating speeds, centrifuge 5 minutes.
Embodiment 1
Centrifugation pipe cap 1 and centrifuge body 7 and form the outer wall structure of whole cell collection device, itself and conventional centrifugation Tubular construction is similar, and difference is that centrifugation pipe cap 1 is longer than conventional centrifugal pipe cap, can put into it collecting pipe main body 5, receive Collector edge 2 can be placed between centrifugation pipe cap 1 and centrifugation body 7 just, when tightening centrifugation pipe cap 1, by centrifuging pipe cap 1 With the extruding of centrifugation body 7, centrifugation pipe cap 1, collecting pipe edge 2, centrifugation body 7 can be made to combine closely, reach sealing state;
Collecting pipe main body 5 and collecting pipe filter window 8 link together, and the volume of collecting pipe main body 5 is larger, can accommodate 15ml's Liquid, its lower end are the arcs gradually tapered up, and when its diameter and collecting pipe filter 8 suitable size of window, it is gradually evolved into Collecting pipe filters window 8;
Collecting pipe filter window 8 is double-deck pipeline, has several openings on duct wall, forms several small windows.Use every time when Wait, need to collecting pipe filter window 8 double-skin duct space in place milipore filter, the diameter of milipore filter at 0.22 micron, meanwhile, also need Milipore filter is placed into the space inside bottom buckle closure 9, the diameter of milipore filter is at 0.22 micron.
Bottom buckle closure 9 is arranged at the bottom of collecting pipe filter window 8, and the one end of bottom buckle closure 9 is connected with collecting pipe filter window wall 12, another End is not connected to, can reflexed back and forth downwards upwards, it is hollow buckle 11 that its movable end, which has centre,, can be with when using at that time Itself and the buckle closure excrescence 10 on collecting pipe filter window wall 12 are formed into close bayonet socket cynapse composite, securely fix bottom button Lid 9, it can not still be opened when centrifugation.
When use, milipore filter is installed, bottom buckle closure 9 fastens, and then loads centrifugation main body 7 to collecting pipe main body 5 It is interior, to the pouring liquid of collecting pipe main body 5, when liquid reaches maximum scale line, centrifugation pipe cap 1 is tightened, is then placed within centrifugation Centrifuged inside machine, the utility model is vertical with the rotary shaft of centrifuge using horizontal centrifugal, i.e. centrifuge tube long axis. Using 15ml as once, 1000rpm/min revolutions, centrifuge 5 minutes.Centrifugation 35 times by several times, first 33 times according to every pipe centrifugation 15ml's Volume, the 34th centrifugation 5ml volume, the 35th time, the cell mass obtained after first 34 times centrifugations is re-mixed at the 35th time Inside centrifuge tube, ascites is added, after fully mixing, is centrifuged, with 1000rpm/min rotating speeds, centrifuged 5 minutes.
After 5 minutes, stop centrifugation, open centrifugation pipe cap 1, collecting pipe main body 5 is taken out, the liquid in body 7 will be centrifuged Outwell;The bottom buckle closure 9 of the lower section of collecting pipe main body 5 is opened, is filtered with pincet from collecting pipe in the gap of window wall 12 and takes out milipore filter, The cell mass by centrifuging the oval column type being molded is poured out, carries out corresponding subsequent experimental processing.
It is described above simply to illustrate that the principle of the utility model.Further, since this utility model operating technology Dexterity easily causes the utility model to produce many changes, and any one skilled in the art is new in this practicality In the technical scope that type discloses, the change or replacement that can readily occur in should all be covered within the scope of protection of the utility model.
The content not being described in detail in this specification belongs to prior art known to professional and technical personnel in the field.

Claims (8)

  1. A kind of 1. cell collection device, it is characterised in that including:Centrifuge pipe cap (1), centrifugation body (7), collecting pipe main body (5) With collecting pipe filter window (8);
    The centrifugation body (7) is provided with centrifuge tube external screw thread (3) and centrifuge tube internal thread (4);
    The upper end of the collecting pipe main body (5) is provided with collecting pipe edge (2);
    The collecting pipe main body (5) is placed in centrifugation body (7), collecting pipe edge (2) is arranged at the upper of centrifugation body (7) End, collecting pipe main body (5) are fixedly connected by centrifuge tube internal thread (4) with centrifugation body (7), and centrifugation pipe cap (1) passes through centrifugation Pipe external screw thread (3) is fixedly connected with centrifugation body (7), collecting pipe edge (2) is placed in centrifugation pipe cap (1), and make centrifuge tube Cap (1), collecting pipe edge (2) and centrifugation body (7) are combined closely, and reach sealing state;
    The lower end of the collecting pipe main body (5) is connected with the upper end of collecting pipe filter window (8).
  2. 2. cell collection device as claimed in claim 1, it is characterised in that the collecting pipe filter window (8) is double-skin duct, pipe Road wall is provided with multiple openings, forms multiple small windows;Milipore filter is provided with the space of the double-skin duct.
  3. 3. cell collection device as claimed in claim 1, it is characterised in that the outer surface of the collecting pipe filter window (8) is receipts Collector filter window wall (12), the collecting pipe filter window wall (12) include:Wall (121) and collecting pipe filter window inwall outside window for collecting pipe filter (122), collecting pipe filter is provided with milipore filter between wall (121) and collecting pipe filter window inwall (122) outside window.
  4. 4. cell collection device as claimed in claim 1, it is characterised in that the lower end of the collecting pipe filter window (8) is provided with bottom Portion's buckle closure (9), the left side upper end of bottom buckle closure (9) is fixedly connected with collecting pipe filter window wall (12), on the right side of bottom buckle closure (9) End is hollow buckle (11) provided with centre, and the right side lower end of collecting pipe filter window wall (12) is provided with buckle closure excrescence (10), buckle closure Excrescence (10) is flexibly connected to form close buckle cynapse composite with buckle (11), for fixing bottom buckle closure (9) Right side upper end;The lower end of the bottom buckle closure (9) is hanging;
    Milipore filter is provided with the internal voids of the bottom buckle closure (9).
  5. 5. the cell collection device as described in claim 2-4 any claims, it is characterised in that the diameter of the milipore filter Between 0.22-0.45 microns.
  6. 6. cell collection device as claimed in claim 3, it is characterised in that the outer wall of collecting pipe main body (5) is collecting pipe master Body wall (6), the lower end of collecting pipe main wall (6) are connected with the upper end of collecting pipe filter window wall (12).
  7. 7. cell collection device as claimed in claim 1, it is characterised in that the outer wall of the centrifugation body (7) is centrifuge tube Main wall (13).
  8. 8. cell collection device as claimed in claim 1, it is characterised in that the centrifugation that the cell collection device uses It is horizontal centrifugal.
CN201721156949.6U 2017-09-11 2017-09-11 A kind of cell collection device Active CN207193277U (en)

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Application Number Priority Date Filing Date Title
CN201721156949.6U CN207193277U (en) 2017-09-11 2017-09-11 A kind of cell collection device

Publications (1)

Publication Number Publication Date
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109735438A (en) * 2018-12-12 2019-05-10 山西中医药大学 A system for reproducing the gut microbiome in vitro and methods for its application

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109735438A (en) * 2018-12-12 2019-05-10 山西中医药大学 A system for reproducing the gut microbiome in vitro and methods for its application

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