CN1939255B - Chitin tooth paste - Google Patents
Chitin tooth paste Download PDFInfo
- Publication number
- CN1939255B CN1939255B CN2005100171735A CN200510017173A CN1939255B CN 1939255 B CN1939255 B CN 1939255B CN 2005100171735 A CN2005100171735 A CN 2005100171735A CN 200510017173 A CN200510017173 A CN 200510017173A CN 1939255 B CN1939255 B CN 1939255B
- Authority
- CN
- China
- Prior art keywords
- chitosan
- molecular weight
- chitin
- agent
- toothpaste
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 229940034610 toothpaste Drugs 0.000 title claims abstract description 35
- 239000000606 toothpaste Substances 0.000 title claims abstract description 35
- 229920002101 Chitin Polymers 0.000 title claims abstract description 14
- 229920001661 Chitosan Polymers 0.000 claims abstract description 33
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 9
- 229910052500 inorganic mineral Inorganic materials 0.000 claims abstract description 7
- 239000011707 mineral Substances 0.000 claims abstract description 7
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 5
- 239000000796 flavoring agent Substances 0.000 claims abstract description 3
- 239000004088 foaming agent Substances 0.000 claims abstract description 3
- 235000013355 food flavoring agent Nutrition 0.000 claims abstract description 3
- 229920002521 macromolecule Polymers 0.000 claims description 4
- 230000003110 anti-inflammatory effect Effects 0.000 claims description 3
- -1 antiprecipitant Substances 0.000 claims description 2
- 230000001954 sterilising effect Effects 0.000 abstract description 7
- 210000004872 soft tissue Anatomy 0.000 abstract description 4
- 230000006378 damage Effects 0.000 abstract description 3
- 206010061218 Inflammation Diseases 0.000 abstract 1
- 230000000249 desinfective effect Effects 0.000 abstract 1
- 235000003599 food sweetener Nutrition 0.000 abstract 1
- 210000000214 mouth Anatomy 0.000 abstract 1
- 239000003765 sweetening agent Substances 0.000 abstract 1
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
- 230000000844 anti-bacterial effect Effects 0.000 description 6
- 239000003292 glue Substances 0.000 description 4
- 238000004659 sterilization and disinfection Methods 0.000 description 4
- 230000000694 effects Effects 0.000 description 3
- 238000003756 stirring Methods 0.000 description 3
- 238000005406 washing Methods 0.000 description 3
- 241000894006 Bacteria Species 0.000 description 2
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- 241000238424 Crustacea Species 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 229910021538 borax Inorganic materials 0.000 description 2
- 230000006196 deacetylation Effects 0.000 description 2
- 238000003381 deacetylation reaction Methods 0.000 description 2
- 238000007872 degassing Methods 0.000 description 2
- 210000004268 dentin Anatomy 0.000 description 2
- 238000000605 extraction Methods 0.000 description 2
- 239000002783 friction material Substances 0.000 description 2
- 230000002779 inactivation Effects 0.000 description 2
- 239000013521 mastic Substances 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 239000004328 sodium tetraborate Substances 0.000 description 2
- 235000010339 sodium tetraborate Nutrition 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- FFRBMBIXVSCUFS-UHFFFAOYSA-N 2,4-dinitro-1-naphthol Chemical compound C1=CC=C2C(O)=C([N+]([O-])=O)C=C([N+]([O-])=O)C2=C1 FFRBMBIXVSCUFS-UHFFFAOYSA-N 0.000 description 1
- 241000606749 Aggregatibacter actinomycetemcomitans Species 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- 241000222122 Candida albicans Species 0.000 description 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 208000025157 Oral disease Diseases 0.000 description 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 1
- 241000589517 Pseudomonas aeruginosa Species 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- 208000026137 Soft tissue injury Diseases 0.000 description 1
- 241000191940 Staphylococcus Species 0.000 description 1
- 241000191963 Staphylococcus epidermidis Species 0.000 description 1
- 241000194019 Streptococcus mutans Species 0.000 description 1
- 230000003385 bacteriostatic effect Effects 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 229910000019 calcium carbonate Inorganic materials 0.000 description 1
- 229940095731 candida albicans Drugs 0.000 description 1
- 239000006229 carbon black Substances 0.000 description 1
- 239000001569 carbon dioxide Substances 0.000 description 1
- 229910002092 carbon dioxide Inorganic materials 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 239000000084 colloidal system Substances 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 230000000254 damaging effect Effects 0.000 description 1
- 210000003298 dental enamel Anatomy 0.000 description 1
- 230000003544 deproteinization Effects 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000006260 foam Substances 0.000 description 1
- 208000007565 gingivitis Diseases 0.000 description 1
- 238000007654 immersion Methods 0.000 description 1
- 239000002917 insecticide Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 description 1
- 229910052753 mercury Inorganic materials 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 208000030194 mouth disease Diseases 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 201000001245 periodontitis Diseases 0.000 description 1
- 239000011574 phosphorus Substances 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000010298 pulverizing process Methods 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 230000000630 rising effect Effects 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
Landscapes
- Cosmetics (AREA)
Abstract
A chitin tooth-paste with high sterilizing and disinfecting effect and no damage to the teeth and soft tissue in oral cavity is prepared proportionally from foaming agent, sweetening agent, flavouring agent, antisettling agent, mineral rubbing agent, inorganic inflammation-relieving agent, water and the chitosan playing the rubbing role.
Description
Technical field
The invention belongs to daily hygiene articles for use technical field, be specifically related to a kind of toothpaste, classification position is at A61K7/16.
Background technology
At present, have only a few peoples not suffer from odontopathy, the control of odontopathy is the important topic that is of universal significance, and in the case, the health care and the therapeutical effect of the toothpaste of expansion daily cleaning tooth enjoy the manufacturer of research, treatment personnel and the toothpaste of odontopathy to pay attention to.Though the medicated toothpaste on the market is varied, also not form by the consistent product of admitting of user.The health care, therapeutic effect of this explanation medicated toothpaste in the past and unlike producer's propaganda and user expectation.
The unique physical and chemical properties and the biological activity of the chitosan (Chitosan) that is become behind deacetylate with the chitin (Chitin) of the shell of crustacean and insecticide and other invertebrates shell extraction have caused the concern of stomatology field to it.The chitosan chemical name is [(1,4)-2-acetylaminohydroxyphenylarsonic acid 2-deoxidation-β-D-glucose], and molecular formula is (C8H13N05) n.It is the high-quality friction material that substitutes the white carbon black in the toothpaste through the water-soluble elastic particle that forms after bloated; The sterilization of chitosan, antiinflammation are the utilized medicines of treatment oral disease.Before this, abroad occurred it is dosed the chitin tooth paste that forms in the toothpaste.As: the SHAKLEE chitin tooth paste of Japanese ゼ ォ Zhu テ formula meeting new production, the ELCHITO chitin tooth paste that Korea S ASEANA drugmaker produces.Utilize its not friction function of damage tooth and oral soft tissue, avoid the disadvantage of enamel attenuation that toothpaste mineral friction material in the past brings, dentin hypersensitiveness (to hot and cold, sour, sweet, pressure etc.) and soft tissue injury (one of paathogenic factor of gingivitis or periodontitis), and had to a certain degree sterilization and antiinflammation.
Confirm that through the home and abroad recent research chitosan of different molecular weight is antibacterial different with sterilization effects, the low-molecular-weight chitosan after the modification have than antibacterial, the sterilizing ability of the chitosan of the amount of not modified big branch be eager to excel many.The chitosan that usefulness deacetylations such as Choi BK are 91.5%, molecular weight is 30KD suppresses bacterium actinomycetem comitans and Streptococcus mutans, and the result is with 2 bacterium colony units of chitosan 30min inactivation of 0.1%, 4.5 bacterium colony units of 120min inactivation.Hu Ying etc. have measured antibacterial, the bactericidal activity of six kinds of different molecular weights to golden yellow staphylococcus, staphylococcus epidermidis, escherichia coli, bacillus pyocyaneus, Candida albicans, and the result shows that along with the rising of molecular weight, the high earlier back of bacteriostatic activity is low.Show after tested, chitosan is the not modified macromolecular structure of molecular weight 100-300KD in the aforementioned external toothpaste, this explanation, existing chitosan toothpaste, only give full play to the not damaged rubbing action of chitosan, failed to give full play to antibacterial, the bactericidal action of chitosan.
Summary of the invention
The purpose of this invention is to provide a kind of chitin tooth paste, overcome existing chitin tooth paste above shortcomings.
Chitin tooth paste of the present invention comprises foaming agent, the sweeting agent of common usage ratio in the existing ordinary toothpaste, flavouring agent, antiprecipitant, mineral abrasive, inorganic antiinflammatory, water, the improvement of being done is to add to account for toothpaste gross weight 3-7%, the macromolecule chitosan of molecular weight 100-300 ten thousand D, adding accounts for toothpaste gross weight 0.05-0.15%, and molecular weight is the small-molecular weight chitosan of 27-35 ten thousand D.
The macromolecule chitosan optimal addn of molecular weight 100-300 ten thousand D is 5% of a toothpaste gross weight among the present invention, and molecular weight is that the small-molecular weight chitosan optimal addn of 27-35 ten thousand D is 0.1% of toothpaste gross weight.
Good effect of the present invention is: since with the chitosan volume of mineral abrasive identical weight be about 10 times of mineral abrasive, so chitosan addition of the present invention, can substitute traditional toothpaste mineral abrasive and play main friction effect, avoid the damage of toothpaste tooth and oral soft tissue.The adding of the chitosan of small-molecular weight can have been given full play to the sterilizing function of chitosan, obtains a kind of dentin and oral soft tissue of promptly not damaging, and sterilization, antiinflammatory effect are again apparently higher than the chitin tooth paste of external like product.
The specific embodiment
The extraction of 1 chitosan, purification and molecular weight are modified.(commodity)
(1) shell of crustacean or other invertebrates shell are through selection, washing removal of contamination;
(2) room temperature is dried back pulverizing 50-70 order; Calcium, phosphorus are sloughed in alcohol immersion with 4-6%HLC;
(3) room temperature clear water washing when washing to PH5.5-6.5, adds 10%NaOH and carry out 2-4h defat, deproteinization under 90-95 ℃ of condition;
(4) be washed till PH5.5-6.5 with clear water, add 40%NaOH, 24h deacetylation under 90 ℃ of conditions, the reuse clear water is washed till PH5.5-6.5, and 100 ℃ of oven dry get chitosan, be crushed to? order, standby;
(5) with the conventional acid method of modifying the chitosan molecule amount is modified to 27-35 ten thousand.
2, the preparation of toothpaste
(1) glue water: get in sorbitol 180g, glucide 2g, Borax 25g, CMC 1g, the water 280g adding glue water pot, stir;
(2) grind: with colloid mill glue is ground one time, deposit more than 6 hours;
(3) system cream: the glue that step (2) is obtained, the chitosan powder 50g, chitosan powder 1g, the CMC10g of molecular weight 300,000 D, calcium carbonate 400g, Borax 25g, carbon dioxide 10g, the essence 13g that add molecular weight 100-300 ten thousand D add successively and stir, pour in the storage tank quiet putting more than 5 hours into by pump;
(4) grind: mastic is ground 1-2 all over (deciding on fineness);
(5) degassing: an amount of mastic-below the 0.092Mpa (or 73a millimetres of mercury), stir and outgased 12-15 minute;
(6) mastic after the degassing is installed in the container of regulation.
The technical specification of the resulting toothpaste of present embodiment: pH value: 7.5～7.94; Stability: (national standard) meets the requirements; Denseness: 18mm; Viscosity: 270Pa.s; Foam volume: 60mm.
Claims (2)
1. chitin tooth paste, by foaming agent, sweeting agent, flavouring agent, antiprecipitant, mineral abrasive, inorganic antiinflammatory, water, chitosan are formed, it is characterized in that: the chitosan that is added contains and accounts for toothpaste gross weight 3-7%, the macromolecule chitosan of molecular weight 100-300 ten thousand D and account for toothpaste gross weight 0.05-0.15%, molecular weight is the small-molecular weight chitosan of 27-35 ten thousand D.
2. according to a kind of chitin tooth paste of claim 1, it is characterized in that: the macromolecule chitosan addition of molecular weight 100-300 ten thousand D is 5% of a toothpaste gross weight, and molecular weight is that the small-molecular weight chitosan addition of 27-35 ten thousand D is 0.1% of toothpaste gross weight.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2005100171735A CN1939255B (en) | 2005-09-30 | 2005-09-30 | Chitin tooth paste |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2005100171735A CN1939255B (en) | 2005-09-30 | 2005-09-30 | Chitin tooth paste |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1939255A CN1939255A (en) | 2007-04-04 |
| CN1939255B true CN1939255B (en) | 2010-04-21 |
Family
ID=37957968
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2005100171735A Expired - Fee Related CN1939255B (en) | 2005-09-30 | 2005-09-30 | Chitin tooth paste |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1939255B (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103655306A (en) * | 2013-12-03 | 2014-03-26 | 青岛海芬海洋生物科技有限公司 | Antisepsis and anti-inflammation toothpaste without preservative and preparation method thereof |
| CN104546541A (en) * | 2015-01-26 | 2015-04-29 | 莫治玲 | Chitosan toothpaste |
| CN105168019A (en) * | 2015-10-26 | 2015-12-23 | 青岛高新区尚达医药研究所 | Chitin toothpaste and preparation method thereof |
| CN105213215A (en) * | 2015-10-28 | 2016-01-06 | 江西省三抗保健品有限公司 | A kind of chitin tooth-caring toothpaste |
| CN106727006A (en) * | 2016-12-30 | 2017-05-31 | 泉州亚林新材料科技有限公司 | A kind of shitosan toothpaste and preparation method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4512968A (en) * | 1982-11-30 | 1985-04-23 | Lion Corporation | Oral compositions |
| US5711938A (en) * | 1994-05-04 | 1998-01-27 | Medicarb Ab | Oral hygiene composition |
| WO2000016735A1 (en) * | 1998-09-17 | 2000-03-30 | Cognis Deutschland Gmbh | Use of monoglyceride (ether) sulfates and chitosan in oral and dental hygiene products |
-
2005
- 2005-09-30 CN CN2005100171735A patent/CN1939255B/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4512968A (en) * | 1982-11-30 | 1985-04-23 | Lion Corporation | Oral compositions |
| US5711938A (en) * | 1994-05-04 | 1998-01-27 | Medicarb Ab | Oral hygiene composition |
| WO2000016735A1 (en) * | 1998-09-17 | 2000-03-30 | Cognis Deutschland Gmbh | Use of monoglyceride (ether) sulfates and chitosan in oral and dental hygiene products |
Non-Patent Citations (1)
| Title |
|---|
| JP特开2002-306090A 2002.10.22 |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1939255A (en) | 2007-04-04 |
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| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C17 | Cessation of patent right | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20100421 Termination date: 20110930 |