CN1985167A - Cartridge and sensor-dispensing instrument - Google Patents
Cartridge and sensor-dispensing instrument Download PDFInfo
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- CN1985167A CN1985167A CN 200580020839 CN200580020839A CN1985167A CN 1985167 A CN1985167 A CN 1985167A CN 200580020839 CN200580020839 CN 200580020839 CN 200580020839 A CN200580020839 A CN 200580020839A CN 1985167 A CN1985167 A CN 1985167A
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Abstract
A disposable cartridge adapted to be used with a sensor-dispensing instrument comprises a housing, test sensors, a mechanical mechanism and moveable seals. The housing forms at least one opening there through. The test sensors are stacked in the housing. The test sensors are adapted to assist in testing at least one analyte. The mechanical mechanism is adapted to urge the test sensors in a first direction. One of the test sensors is positioned for ejection from the cartridge. The moveable seals is adapted to be in a closed position that seals the at least one opening so as to provide a substantially moisture-proof and a substantially air-tight cartridge, and one of the moveable seals is adapted to be in an open position that allows one of the test sensors to be moved therethrough.
Description
Technical field
The present invention relates generally to a kind of tube and sensor-dispensing instrument, and more specifically, relates to a kind of tube that comprises a plurality of sensors, blood sugar or other analyte that described sensor is used to analyze in the tube and is comprised.
Background technology
In the process of diagnosis and some physiological maladies of maintenance, determine that quantitatively the analyte in the body fluid is very important.For example, should monitor some intraindividual lactate, cholesterol and cholerythrin.Particularly, for diabetic's individuality of regulating the glucose intake in the diet, determine that the glucose in the body fluid is important for the glucose level in the necessary frequent inspection body fluid.Although all the other contents that this paper discloses will should be appreciated that at the determining of glucose, can utilize method of the present invention to determine other analyte based on selecting suitable enzyme.
Take insulin or other medicines if desired, then can utilize the result of this test to determine to take what insulin or other medicines.In a class blood sugar test system, utilize sensor test fluid such as blood sample.
Sensor comprises biological sensing material or reagent material, and described material will react with blood sugar.The test lead of sensor is suitable for being placed in the fluid of testing and for example accumulates in after being stung in the finger brokenly in the blood on the finger.Fluid is inhaled in sensor by capillarity and extends in the capillary channel of reagent material from test lead, so that the fluid of testing of q.s is inhaled in the sensor.Fluid subsequently with sensor in reagent material carry out chemical reaction, cause producing the electric signal of the glucose level in the fluid that indication tests, described electric signal is provided to the contact area that is positioned at proximity transducer rear portion or contact jaw.
This sensor is comparatively responsive for the influence of ambient humidity usually.A kind of mode that reduces or eliminates the ambient humidity influence is to utilize drying agent to encapsulate each sensor independently.The shortcoming of this method is, all needs to take apart strip before each the use.Therefore, expectation has a kind of tube that comprises a plurality of testing sensors, and described tube makes and do not need to take apart before use each strip.In addition, for ease of and be easy to use for the purpose of, also expectation has a kind of simple mechanism, described simple mechanism is each supplies with a testing sensor so that the user tests.This makes that ordinary consumer is easy to use and be even more important for those users of some defective of health.
Summary of the invention
According to an embodiment, a kind of tube of disposing is suitable for using with sensor-dispensing instrument.The described tube of disposing comprises housing, a plurality of testing sensor, mechanical mechanism and a plurality of dynamic seal.Described housing has formed at least one opening that passes through wherein.Described a plurality of testing sensor is stacked in the described housing.Described a plurality of testing sensor is suitable for helping at least a analyte of test.Described mechanical mechanism is suitable for promoting described a plurality of testing sensor along first direction.A testing sensor in described a plurality of testing sensor is placed to be ejected from described tube.Described a plurality of dynamic seal is suitable for being in the close position the place, described at least one opening is sealed so that moistureproof and airtight substantially substantially tube is provided in the described a plurality of dynamic seal of described closed position.A dynamic seal in described a plurality of dynamic seal is suitable for being shown in an open position the place, allows a testing sensor in described a plurality of testing sensor to move through described dynamic seal in the described dynamic seal of described open position.
According to another embodiment, a kind of tube of disposing is suitable for using with sensor-dispensing instrument.The described tube of disposing comprises housing, a plurality of testing sensor, mechanical mechanism and at least one dynamic seal.Described housing has formed at least one opening that passes through wherein.Described a plurality of testing sensor is stacked in the described housing.Described a plurality of testing sensor is suitable for helping at least a analyte of test.Described mechanical mechanism is suitable for promoting described a plurality of testing sensor along first direction.Described dynamic seal is suitable for being in the close position the place, described at least one opening is sealed so that moistureproof and airtight substantially substantially tube is provided in the described dynamic seal of described closed position.Described dynamic seal is suitable for being shown in an open position the place, allows a testing sensor in described a plurality of testing sensor to move through described dynamic seal in the described dynamic seal of described open position.
According to an embodiment, a kind of sensor-dispensing instrument comprises can dispose tube, apparatus shell and pusher assembly.The described tube of disposing comprises housing, a plurality of testing sensor, mechanical mechanism and at least one dynamic seal.Described housing has formed at least one opening that passes through wherein.Described a plurality of testing sensor is stacked in the described housing.Described a plurality of testing sensor is suitable for helping at least a analyte of test.Described mechanical mechanism is suitable for promoting a testing sensor in described a plurality of testing sensor along first direction.A testing sensor in described a plurality of testing sensor is placed to be ejected from described tube.Described at least one dynamic seal is suitable for being in the close position the place, described at least one opening is sealed so that moistureproof and airtight substantially substantially tube is provided in described at least one dynamic seal of described closed position.Described at least one dynamic seal is suitable for being shown in an open position the place, allows a testing sensor in described a plurality of testing sensor to move through described at least one dynamic seal in described at least one dynamic seal of described open position.Described housing has formed and has distributed outlet and be suitable for receiving the described tube of disposing.Described pusher assembly comprises the slider that is attached to described pusher assembly and approaches flat.Described flat is suitable for sliding to the second place from primary importance under the migration of described pusher assembly.Described flat from described primary importance to the process that the described second place moves, described flat contact in described a plurality of testing sensors a testing sensor and promote described testing sensor at least in part by at least one described dynamic seal.
According to another embodiment, a kind of tube of disposing is suitable for using with sensor-dispensing instrument.The described tube of disposing comprises housing, a plurality of testing sensor, comprises mechanical mechanism and a plurality of dynamic seal of torsion spring.Described housing has formed at least one opening that passes through wherein.Described a plurality of testing sensor is stacked in the described housing.Described a plurality of testing sensor is suitable for helping at least a analyte of test.Described mechanical mechanism is suitable for promoting described a plurality of testing sensor along first direction.A testing sensor in described a plurality of testing sensor is placed to be ejected from described tube.Described a plurality of dynamic seal is suitable for being in the close position the place, described at least one opening is sealed so that moistureproof and airtight substantially substantially tube is provided in the described a plurality of dynamic seal of described closed position.A dynamic seal in described a plurality of dynamic seal is suitable for being shown in an open position the place, allows a testing sensor in described a plurality of testing sensor to move through described dynamic seal in the described dynamic seal of described open position.
According to another embodiment, a kind of tube of disposing is suitable for using with sensor-dispensing instrument.The described tube of disposing comprises housing, a plurality of testing sensor, comprises mechanical mechanism and at least one dynamic seal of torsion spring.Described housing has formed at least one opening that passes through wherein.Described a plurality of testing sensor is stacked in the described housing.Described a plurality of testing sensor is suitable for helping at least a analyte of test.Described mechanical mechanism is suitable for promoting described a plurality of testing sensor along first direction.Described dynamic seal is suitable for being in the close position the place, described at least one opening is sealed so that moistureproof and airtight substantially substantially tube is provided in the described dynamic seal of described closed position.Described dynamic seal is suitable for being shown in an open position the place, allows a testing sensor in described a plurality of testing sensor to move through described dynamic seal in the described dynamic seal of described open position.
According to another embodiment, a kind of sensor-dispensing instrument comprises the mechanism that the heap that can dispose tube, apparatus shell and make single-sensor and a plurality of sensors separates.The described tube of disposing comprises housing, a plurality of testing sensor, comprises mechanical mechanism and at least one dynamic seal of torsion spring.Described housing has formed at least one opening that passes through wherein.Described a plurality of testing sensor is stacked in the described housing.Described a plurality of testing sensor is suitable for helping at least a analyte of test.Described mechanical mechanism is suitable for promoting a testing sensor in described a plurality of testing sensor along first direction.A testing sensor in described a plurality of testing sensor is placed to be ejected from described tube.Described at least one dynamic seal is suitable for being in the close position the place, described at least one opening is sealed so that moistureproof and airtight substantially substantially tube is provided in described at least one dynamic seal of described closed position.Described at least one dynamic seal is suitable for being shown in an open position the place, allows a testing sensor in described a plurality of testing sensor to move through described at least one dynamic seal in described at least one dynamic seal of described open position.Described housing has formed and has distributed outlet and be suitable for receiving the described tube of disposing.The mechanism that the described heap that makes single-sensor and a plurality of sensors separates comprises the pusher assembly.Described pusher assembly comprises the slider that is attached to described pusher assembly and approaches flat.Described flat is suitable for sliding to the second place from primary importance under the migration of described pusher assembly.Described flat from described primary importance to the process that the described second place moves, described flat contact in described a plurality of testing sensors a testing sensor and promote described testing sensor at least in part by at least one described dynamic seal.
Description of drawings
Fig. 1 a is the front view of the main housing portion of tube according to an embodiment of the invention;
Fig. 1 b is the front view of the lid housing parts of tube according to an embodiment of the invention;
Fig. 1 c is the side view of the tube shown in Fig. 1 a and Fig. 1 b;
Fig. 1 d is the front view with main housing portion of the tube shown in Fig. 1 a of volute spring;
Fig. 1 e is the front view with main housing portion of the tube shown in Fig. 1 a of back taper spring;
Fig. 1 f is the front view with main housing portion of the modification tube shown in Fig. 1 a of the torsion spring that is in the close position the place;
Fig. 1 g is the front view with main housing portion of the modification tube shown in Fig. 1 a of the torsion spring that is shown in an open position the place;
Fig. 2 a is the top view according to the duckbill seal of an embodiment;
Fig. 2 b is the cut-open view that intercepts along the line 2b-2b shown in Fig. 2 a substantially;
Fig. 2 c is the cut-open view with the seal shown in Fig. 2 b that is shown in an open position the place of testing sensor;
Fig. 2 d is the top view according to the duckbill seal of another embodiment;
Fig. 2 e is the skeleton view of the seal shown in Fig. 2 d;
Fig. 2 f is the cut-open view that intercepts along the line 2f-2f shown in Fig. 2 d substantially;
Fig. 2 g is the cut-open view with the seal shown in Fig. 2 f that is shown in an open position the place of testing sensor;
Fig. 3 a is the top view according to the seal of another embodiment;
Fig. 3 b is the top view according to the seal of an embodiment;
Fig. 4 is the front view of tube according to still another embodiment of the invention;
Fig. 5 is the front view of tube according to still a further embodiment;
Fig. 6 is the front view of tube according to another embodiment of the invention;
Fig. 7 a is the front view of tube according to another embodiment of the invention;
Fig. 7 b is the side view of the tube shown in Fig. 7 a;
Fig. 8 a is the front view of tube according to still another embodiment of the invention;
Fig. 8 b is the side view of the tube shown in Fig. 8 a;
Fig. 9 is the front view of sensor-dispensing instrument according to an embodiment of the invention;
Figure 10 a is the top view with sensor-dispensing instrument shown in Figure 9 of the slider that is in the primary importance place;
Figure 10 b is the top view with sensor-dispensing instrument shown in Figure 9 of the slider that is in second place place;
Figure 10 c is the cut-open view that intercepts along line 10c-10c shown in Figure 9 substantially;
Figure 11 is the internal view with the flat sensor-dispensing instrument shown in Figure 9 that is in the primary importance place;
Figure 12 is the internal view with the flat sensor-dispensing instrument shown in Figure 9 shown in Figure 11 that is in second place place;
Figure 13 is the flat zoomed-in view that will contact testing sensor state before according to being in of an embodiment;
Figure 14 is the front view of sensor-dispensing instrument, and wherein slider has a plurality of potential sites;
Figure 15 is the cut-open view according to the slider of another embodiment; With
Figure 16 is the cut-open view according to the slider of another embodiment.
Although the present invention is easy to produce multiple modification and other optional form, shows specific embodiment and in this article described specific embodiment is described in detail by the example among the figure.Yet, should be appreciated that the present invention is not intended to be limited to disclosed particular form.But the present invention is intended to cover all modification, equivalent way and other the optional mode that falls in the spirit and scope of the present invention that are defined by the following claims.
Embodiment
The present invention is directed to a kind of tube disposed that comprises a plurality of testing sensors.A plurality of testing sensors are used to determine analyte concentration.The analyte that can utilize the present invention to measure comprises glucose, lipid (lipid profiles) (for example cholesterol, triglyceride, low-density lipoprotein and high-density lipoprotein (HDL)), microalbumin (microalbumin), hemoglobin A
1C, fructose, lactate or cholerythrin.Yet, the invention is not restricted to the concentration that these specific analyte and conception can be determined other analyte.Analyte for example can be in whole blood sample, blood serum sample, plasma sample or other body fluid such as ISF (interstitial fluid) and the urine.
Can dispose tube
Referring to accompanying drawing, Fig. 1 a-Fig. 1 c shows and can dispose tube 10, and the described tube of disposing is applicable in the sensor-dispensing instrument.Tube 10 is moistureproof substantially and airtight device.The tube disposed 10 shown in Fig. 1 a, Fig. 1 c comprises housing 12, a plurality of testing sensor 14, mechanical mechanism 16 and a plurality of dynamic seal 18.The housing 12 that can dispose tube 10 can comprise first section (the main casing body section 11 shown in Fig. 1 a) and second section (the lid shell part 28 shown in Fig. 1 b) that links together.After each testing sensor in a plurality of testing sensors 14 had been used, tube 10 can be suitable for being disposed.After each testing sensor in a plurality of testing sensors 14 has been used, can from sensor-dispensing instrument, removes tube 10 and replace described tube 10 by second the identical tube that comprises a plurality of untapped testing sensors.
Referring to Fig. 1 a, housing 12 has formed at least one opening 20 that passes through wherein.Utilize a plurality of dynamic seal 18a, 18b opening 20 to be sealed two positions.Dynamic seal 18a, 18b prevent or stop air and moisture to enter to comprise the inside of the tube 10 of a plurality of testing sensors 14.The size of opening 20 is suitable for allowing a testing sensor in a plurality of testing sensors 14 also finally to leave tube 10 by described opening at every turn.Particularly, a testing sensor in each a plurality of testing sensor 14 leaves tube 10 by openend 20a.As the ground of below will discussing in more detail, housing 12 also can form at least one and cut 22 help to keep tube to be in appropriate position in the sensor-dispensing instrument.
Housing 12 can be made of a variety of materials, but is made by polymeric material usually.Some examples that can be used for forming the polymeric material of housing 12 comprise polycarbonate, acrylonitrile-butadiene-styrene (ABS) (ABS), nylon, polystyrene, polypropylene or its combination.Can add other adjuvant to form housing, for example add TEFLON
To play lubrication or to add glass so that intensity to be provided.Conception can be adopted other adjuvant.Former thereby expectation adopts polycarbonate, described reason to comprise that polycarbonate is a kind of long life material and has preventing or stop air (especially oxygen and moisture) to enter ability in the housing 12 for some.In addition, if housing is formed by two different portions sections, then polycarbonate can be realized the sealing of self.In the process of utilizing two shell part of ultrasonic soldering, may expect to occur this situation.
In an example, housing 12 comprises main casing body section 11 and lid shell part 28.Lid shell part 11 shown in Fig. 1 b has a plurality of pilot pins 29 so that lid shell part 28 is accurately located with respect to main casing body section 11.Main casing body section 11 shown in Fig. 1 a has formed a plurality of holes 27, receives described pilot pin before linking together by for example ultrasonic soldering mode with the corresponding pilot pin 29 in described hole and lid shell part 11.In order to help to reduce or eliminate the situation that moisture and air enter housing, at least one energy director (energy director) 30 can be added into covers shell part 28 (for example energy director shown in Fig. 1 b) to help the perimembranous of seal casinghousing.Another kind of optional mode is that at least one energy director can be added into main casing body section.The perimembranous that energy director 30 melts and center on housing 12 forms sealing.Another kind of optional mode is that the conception pilot pin can be set on the main casing body section and cover on the shell part and form the hole that receives this pilot pin.Energy director 30 desirably is set up so that the sealing maximization of housing 12.
Can form housing 12 by the known technology of those skilled in the art, described technology comprises injection molding technique.If utilize injection molding technique, then wall thickness is designed to be in the nominal range usually.Conception can utilize other technology such as moulding process.
Shown in Fig. 1 a, Fig. 1 c, a plurality of testing sensors 14 are stacked in the housing 12.A plurality of testing sensors 14 are suitable for helping at least a analyte of test.As top discussion ground, a kind of analyte that can test is the glucose from for example whole blood sample.In one embodiment, thus the analyte that the enzyme that a plurality of testing sensor will comprise suitable selection and required analyte maybe will be tested reacts.The enzyme that can be used for reacting with glucose is a glucose oxidase.Conception can utilize other enzyme such as glucose dehydrogenase.License to the example that has disclosed testing sensor 14 in the U.S. Patent No. 6,531,040 of Bayer company.Be envisaged in to dispose in the tube 10 and can use other testing sensor.
The quantity of a plurality of testing sensors 14 can be different from the quantity shown in Fig. 1 a, Fig. 1 c to satisfy different users's demand.Usually, stacked testing sensor comprises about 10 to about 50 or 100 sensors, and more specifically, comprises about 25 to about 40 sensors.Because the shelf-life and the serviceable life of testing sensor are limited, therefore anticipation, opposite with the user who tests more continually is that the user who does not often test may expect that tube has testing sensor still less.
In order upwards to promote stacked testing sensor 14 (along the direction of arrow A shown in Fig. 1 a, Fig. 1 c), utilize mechanical mechanism 16 according to an embodiment.A testing sensor in a plurality of testing sensors of mechanical mechanism 16 help placements is so that it is finally ejected tube 10 by openend 20a.Thereby mechanical mechanism is any device that can exert pressure on stacked testing sensor 14 and with a testing sensor of placing in a plurality of testing sensors it be ejected.For example, the mechanical mechanism 16 shown in Fig. 1 a, Fig. 1 c is springs.All kinds of springs can be used as mechanical mechanism to promote stacked testing sensor 14 along the direction of arrow A shown in Fig. 1 a, Fig. 1 c.For example, spring can be compression spring or torsion spring.Spring is because its simple and wieldy advantage thereby be that expectation is adopted.
The compression spring of another kind of particular type is shown in Fig. 1 d, 1e.Except mechanical mechanism 15 was volute spring, the tube 10 shown in Fig. 1 d was identical with the tube shown in Fig. 1 a.Except mechanical mechanism 17 was volute spring, the tube 10 shown in Fig. 1 e was also identical with the tube shown in Fig. 1 a.Volute spring 17 shown in Fig. 1 e is compared with the volute spring 15 shown in Fig. 1 d and is reversed.
According to the embodiments of the invention shown in Fig. 1 f, Fig. 1 g, the tube 12 of modification comprises mechanical mechanism 19, and described mechanical mechanism comprises torsion spring 19a and activity pressure plate 19b.Activity pressure plate 19b engaged test sensor heap.Torsion spring 19a comprises stiff end member 19c, and described stiff end member is attached to torsion spring 19a on the cylinder shell 12.Torsion spring 19a also comprises the movable end member 19d of the pivotal point that is attached on the pressure plare 19b.Torsion spring 19a is positioned at the sidepiece of testing sensor heap 14.Torsion spring 19a exerts pressure and helps testing sensor on testing sensor heap 14 and moves up along the direction of arrow A shown in Fig. 1 f and Fig. 1 g.Simultaneously, pressure plare 19b moves and keeps the remainder of sensor heap 14 to be in the appropriate position along equidirectional.
In addition, mechanical mechanism 16 can be the ratchet pusher.Utilize this embodiment, the ratchet pusher automatically upwards promotes stacked testing sensor (that is, along the direction of arrow A shown in Fig. 1 a, Fig. 1 c) gradually.Desired is that the ratchet pusher needs to extend so that finally can utilize all testing sensors along the inner length of tube.Conception ratchet pusher can be used in combination with one or more springs.
In order to help upwards to guide mechanical mechanism 16 (along the direction of arrow A shown in Fig. 1 a, Fig. 1 c), housing 12 is formed has a plurality of teats or extension 24.Optionally teat or extension 24 help along the direction guiding mechanical mechanism 16 that makes progress substantially, therefore make a plurality of testing sensors easier to be mobile in the direction of arrow A.
In order to help to protect the reagent in the testing sensor 14, can utilize the encapsulating material and/or the desiccant material of expectation.Can dispose tube 10 is encapsulated in usually and prevents or stop air to enter to comprise in the material of housing 12 inside of testing sensor 14.Can be used for sealing can dispose the tube 10 a kind of remove the packing be aluminium foil.Conception can be adopted the packing removed of other type.Conception can removed package interior interpolation desiccant material to help to keep therein suitable humidity level.If the reagent in the testing sensor is insensitive for humidity,, also need or do not need to comprise bulk drying agent hardly even then need drying agent.No matter have or not desiccant material, can remove the shelf-life that packing all helps to increase testing sensor.Before tube 10 is placed in the sensor-dispensing instrument, removes this and can remove packing.
Conception can be disposed tube 10 and initially can be placed in the container of polymer container such as bottle or other type.The shape of container can to can dispose the tube similar, described container has the seal of expectation to prevent or to stop air or moisture to enter internal tank.Container can comprise the lid that is attached to the remainder of container by hinges.Conception also can be added drying agent in container.No matter have or not desiccant material, container all helps to increase the shelf-life of testing sensor.Can dispose the tube 10 be placed in the sensor-dispensing instrument before, remove the described tube of disposing from container.
Desiccant material 26 desirably is added into can dispose tube 10 to help keeping suitable humidity level in housing 12 inside that comprise testing sensor 14.Particularly, whenever sensor is pushed out can dispose tin the time, some moisture may enter housing 12 inside, and agent absorbs so that prevent the reagent in the testing sensor and produces degradation but this moisture desirably is dried.By keeping suitable humidity level, protected the reagent material in the testing sensor.The amount of desiccant material 26 should be enough to obtain required shelf-life (any testing sensor in a plurality of testing sensors be used before period).More specifically, if use wrappage, shelf-life is commonly referred to as the period before the removal tube 10 from wrappage.The amount of desiccant material 26 also should be enough to obtain required serviceable life (using the testing sensor period afterwards in a plurality of testing sensors first).More specifically, if use wrappage, be commonly referred to as the period after the removal tube 10 from wrappage serviceable life.
But but in disposal container, in the packing removed of sealing disposal container or the example that comprises the drying agent that can comprise in the container that can dispose tube comprise the commercial drying agent that gets.That drying agent can comprise is spherical, sheet, the form of granular multiple shape or the form of paper exist.For example, drying agent can be molecular sieve spheroid or thick dry paper.Drying agent can be placed in housing 12 inside, for example situation of the desiccant material shown in the figure 26.Drying agent can be molded in the inside surface of housing 12 of tube, so that absorb the moisture in the described inside surface.For example a kind of unrestricted example of the desiccant material that exists with molecular sieve pearl form can be from Multisorb ofBuffalo, and New York has bought at the place.
Conception can not used drying agent for the insensitive testing sensor of humidity.If you are using, then the amount of the drying agent that uses depends on that testing sensor is for the sensitivity of humidity and the duration in required serviceable life.
Seal 18a, 18b are suitable for moving to open position from make-position (as shown in Figure 1a).In closed position, a plurality of seal 18a, 18b sealing comprises the inside of the housing 12 of testing sensor 14.In this closed position, a plurality of seal 18a, 18b provide moistureproof substantially and airtight substantially tube.A plurality of seal 18a, 18b desirably are designed so that at least in the shelf-life and the length of life of a plurality of sensors, prevent or stop moisture to enter by openend 20a, 20b and influence a plurality of testing sensors 14.When dynamic seal 18a is shown in an open position, finally leave by openend 20a thereby can there be a testing sensor 14 to move through opening 20 at every turn.
One type the dynamic seal that can be used in the tube 10 is the duckbill seal.Dynamic seal 18a shown in Fig. 1 a, 18b are the duckbill seals.Referring to Fig. 2 a-Fig. 2 g, there is shown two duckbill seals 18,40 of the dynamic seal that can be used as in the tube.
Referring to Fig. 2 a-Fig. 2 c, duckbill seal 18 as shown in the figure has the circular segments 34 that is the circumferential extension of pyramidal section 32 and edge substantially that is positioned at its middle part.Be pyramidal section 32 substantially and comprise the first outward extending part 32a and the second outward extending part 32b.The first outward extending part 32a comprises that the surperficial 32c and the second outward extending part 32b comprise surperficial 32d.At closed position (Fig. 2 a, Fig. 2 b), the part 36 of each surperficial 32c, 32d is adjacent to each other to form moistureproof substantially and airtight substantially seal.At open position (Fig. 2 c), the first outward extending part 32a and the second outward extending part 32b move or are pushed away from each other, so that allow testing sensor 14 to advance by wherein.
Next referring to Fig. 2 d-Fig. 2 g, duckbill seal 40 as shown in the figure has the circumferential rectangular section 44 of extending of portion's section 42 that is the truncation rectangle substantially and edge that is positioned at its middle part.Rectangular substantially portion's section 42 comprises the first outward extending part 42a and the second outward extending part 42b.The first outward extending part 42a comprises that the surperficial 42c and the second outward extending part 42b comprise surperficial 42d.At closed position (Fig. 2 d-Fig. 2 f), the part 46 of each surperficial 42c, 42d is adjacent to each other to form moistureproof substantially and airtight substantially seal.At open position (Fig. 2 g), the first outward extending part 42a and the second outward extending part 42b move or are pushed away from each other, so that allow testing sensor 14 to advance by wherein.The shape of conception duckbill seal can be different from the shape of the duckbill seal 18,40 shown in Fig. 2 a-Fig. 2 g.
Duckbill seal 18,40 shown in Fig. 2 a-Fig. 2 g can be made by material such as polymeric material.For example, silicon (as medical silicon), rubber, plastomer, elastic body or other flexible polymeric materials can be used for forming the duckbill seal.Duckbill seal 18,40 need have memory capability to a certain extent.The term as used herein memory is meant that material returns the ability of same position substantially after mobile or stretching.
The dynamic seal of conceiving other type can be used for and can dispose in the tube.For example Fig. 3 a, Fig. 3 b show spring seals.For the purpose of fabricator's cost effectiveness and convenience, spring seals is desirably made by the extrusion modling polymkeric substance.Yet conception can form spring seals by molded and shaped technology.
Referring to Fig. 3 a, spring seals 50 comprises section 50a of spring portion and sealing surfaces 50b.Similarly, spring seals 52 comprises section 52a of spring portion and sealing surfaces 52b.Seal 50,52 1 works to form the make-position shown in Fig. 3 a.More specifically, sealing surfaces 50a, 52b are adjacent to each other.Seal 50,52 can be made by material such as silicon (as medical silicon), rubber, plastomer, elastic body or other flexible polymeric materials.Seal 50,52 need have memory capability to a certain extent.The spring portion section of conception seal 50,52 also can be made by material such as metal.
Fig. 3 b shows the spring seals of another kind of type, spring seals 60,62.Spring seals 60 comprises two section 60a of spring portion and sealing surfaces 60b.Similarly, spring seals 62 comprises two section 62a of spring portion and sealing surfaces 62b.Seal 60,62 1 works to form the make-position shown in Fig. 3 b.More specifically, sealing surfaces 60a, 62b are adjacent to each other.Seal 60,62 can be made by material such as silicon (as medical silicon), rubber, plastomer, elastic body or other flexible polymeric materials.Seal 60,62 need have memory capability to a certain extent.The spring portion section of conception seal 60,62 also can be made by material such as metal.
Referring to Fig. 4, can dispose tube 110 and comprise housing 112, a plurality of testing sensor 114, mechanical mechanism 116 and a plurality of dynamic seal 118.Housing 112 has formed at least one opening 120 that passes through wherein.Tube 110 be can dispose and teat or extension 124 and desiccant material 126 also comprised.
A plurality of dynamic seal 118 comprise the first polymkeric substance hollow pipeline 118a, the second polymkeric substance hollow pipeline 118b, terpolymer hollow pipeline 118c and the 4th polymkeric substance hollow pipeline 118d.The first pipeline 118a and the second pipeline 118b one work to form make-position as shown in Figure 4.The first pipeline 118a and the second pipeline 118b are made by flexible material, and when testing sensor was inserted between described first pipeline and described second pipeline, described flexible material produced distortion.The first pipeline 118a and the second pipeline 118b can be made by material such as silicon (as medical silicon), rubber, plastomer, elastic body or other flexible polymeric materials.The first pipeline 118a and the second pipeline 118b need have memory capability to a certain extent.The 3rd pipeline 118c and the 4th pipeline 118d act in a similar manner, reason is that described pipeline made by flexible material, when the plate of sensor-dispensing instrument extended between described pipeline, described flexible material produced distortion, and this will discuss below in further detail.The 3rd pipeline 118c and the 4th pipeline 118d can be by making with the first pipeline 118a and the second pipeline 118b identical materials.
The mode of action of a plurality of testing sensors 114, mechanical mechanism 116, opening 120, teat or extension 124 and drying agent 126 is with above-mentioned identical with the drying agent 26 described modes of action in conjunction with testing sensor 14, mechanical mechanism 16, opening 20, teat or extension 24.
Referring to Fig. 5, there is shown the tube disposed 160 according to another embodiment.Tube 160 be can dispose and housing 162, a plurality of testing sensor 164, mechanical mechanism 166 and a plurality of dynamic seal 168a, 168b comprised.Housing 162 has formed at least one opening 170 that passes through wherein.Tube 160 be can dispose and teat or extension 174 and desiccant material 176 also comprised.
Dynamic seal 168a, 168b are the pivot seals, and described pivot seal is in the close position the place as shown in Figure 5.In closed position, pivot seal 168a, 168b apply power upwards.When testing sensor was pushed through the opening 170, pivot seal 168a pivoted downwards and away from as shown in Figure 5 opening towards open position.Testing sensor 164 is allowed to continue to advance arrival openend 170a.Pivot seal 168a, 168b can be made by polymeric material such as silicon (as medical silicon), rubber, plastomer, elastic body or other flexible polymeric materials.Pivot seal 168a, 168b need have memory capability to a certain extent.When the plate of sensor-dispensing instrument extended through wherein, pivot seal 168b was suitable for pivoting, and this will discuss below in further detail.
The mode of action of a plurality of testing sensors 164, mechanical mechanism 166, opening 170, teat or extension 174 and drying agent 176 is with above-mentioned identical with the drying agent 26 described modes of action in conjunction with testing sensor 14, mechanical mechanism 16, opening 20, teat or extension 24.
Also conception can only can be disposed tube by a dynamic seal sealing.Fig. 6 shows the example of this embodiment.Referring to Fig. 6, there is shown the tube disposed 260 according to another embodiment.Tube 260 be can dispose and housing 262, a plurality of testing sensor 264, mechanical mechanism 266 and a dynamic seal 268 comprised.Housing 262 has formed at least one opening 270 that passes through wherein.Tube 260 be can dispose and teat or extension 274 and desiccant material 276 also comprised.
Another kind of optional mode is, can dispose after tube is placed in the sensor-dispensing instrument, lid 280 can with can dispose tube and keep together.In this embodiment, remain in sealing state in the process of openend 270b in being placed in sensor-dispensing instrument.In this embodiment, as the following ground of will discussing in more detail, flat will be pierced through or make and cover 280 and break.After being pierced or breaking, flat will form cooperation or sealing closely afterwards in opening 270b in being placed in sensor-dispensing instrument.Lid 280 can be formed by material such as aluminium foil or polymeric material.
The mode of action of a plurality of testing sensors 264, mechanical mechanism 266, opening 270, teat or extension 274 and drying agent 276 is with above-mentioned identical with the drying agent 26 described modes of action in conjunction with testing sensor 14, mechanical mechanism 16, opening 20, teat or extension 24.
But conception disposal container 260 can comprise the seal that is different from seal shown in Figure 6.For example, can utilize other seal discussed above such as dynamic seal 50,118,168 and 218.
Also conception can be used the tube disposed of other shape.For example, referring to Fig. 7 and Fig. 8, there is shown and to dispose tube 310 and can dispose tube 360.Initially, can dispose tube 310 and comprise housing 312, a plurality of testing sensor 314, mechanical mechanism 316 and a plurality of dynamic seal 318 referring to Fig. 7 a, Fig. 7 b.Housing 312 has formed at least one opening 320 that passes through wherein, and a testing sensor in wherein a plurality of testing sensors 314 finally leaves tube 310 by openend 320a.Can dispose the tube 310 and the mode of action of each parts thereof with top combine can dispose tins 10 and the described mode of action of each parts similar.
Can dispose tube is favourable in many aspects.Can dispose the tube desirably be convenient to the sealing, have cost effectiveness and since can utilize top-down assembling mode implementing process process be easy to the manufacturing.
Next referring to Fig. 8, there is shown and to dispose tube 360.Tube 360 be can dispose and housing 362, a plurality of testing sensor 364, mechanical mechanism 366 and a plurality of dynamic seal 368a, 368b comprised.Housing 362 has formed at least one opening 370 that passes through wherein, and a testing sensor in wherein a plurality of testing sensors 364 finally leaves tube 360 by openend 370a.Tube 360 be can dispose and openend 370b, teat 374 and sealant 376 also comprised.Can dispose the tube 360 and the mode of action of each parts thereof with top combine can dispose tins 10 and the described mode of action of each parts similar.
Sensor-dispensing instrument
Referring to Fig. 9-Figure 14, there is shown sensor-dispensing instrument 400 according to an embodiment.Sensor-dispensing instrument is used to determine the concentration of analyte.The analyte that can utilize the present invention to measure comprises glucose, lipid (for example cholesterol, triglyceride, low-density lipoprotein and high-density lipoprotein (HDL)), microalbumin, hemoglobin A
1C, fructose, lactate or cholerythrin.Yet, the invention is not restricted to the concentration that these specific analyte and conception can be determined other analyte.Analyte for example can be in whole blood sample, blood serum sample, plasma sample or other body fluid such as ISF (interstitial fluid) and the urine.
Sensor-dispensing instrument 400 comprises can dispose tube 10, pusher assembly 402 and apparatus shell 404.Shown in Figure 10 c, pusher assembly 402 comprises slider 406 and is attached on the slider 406 thin flat 408.As Figure 11 and shown in Figure 12, apparatus shell 404 is suitable for receiving can dispose tube 10.Tube 10 desirably is removed and is loaded in the described housing from the apparatus shell 404 of sensor-dispensing instrument 400 in easy mode.Figure 11 and apparatus shell 404 shown in Figure 12 can be disposed tube by bottom loaded.Replacement is as bottom loaded device ground, and apparatus shell can be the sidepiece loading attachment.
In order to help to keep tube 10 to be in the apparatus shell 404, can utilize maintaining body 430.Maintaining body 430 is spring-loaded and comprises extension 430a corresponding to the otch 22 (referring to Fig. 1) of tube 10.In the process of handling tube 10, maintaining body 430 is pushed back primary importance (along direction of arrow D shown in Figure 11).After tube 10 was placed in the apparatus shell 404, maintaining body 430 was released and marches to the second place (Figure 11 and Figure 12), and extension 430a engages with otch 22 at described second place place.
Conception can use other can dispose tube, and those can dispose tube as described previously.According to selected tube, the inside of apparatus shell can redesign with corresponding to the selected tube of disposing.Apparatus shell 404 has also formed and has distributed outlet 410, and the size of described distribution outlet is suitable for distributing a testing sensor 14 at every turn.
Referring to Fig. 9 and Figure 10 a, slider 406 is illustrated and is in the primary importance place.Along the slider 406 shown in the manually mobile Fig. 9 of direction of arrow B and Figure 10 a, slider 406 moves to the second place (referring to Figure 10 b) by continuation.Slider 406 shown in Figure 10 b is positioned at the position than the more approaching distribution outlet 410 of the slider shown in Figure 10 a.
Pusher assembly 402 is suitable for making a testing sensor in a plurality of testing sensors 14 to move away and can disposes tube 10 and pass through at least in part and distributes outlet 410, shown in Figure 10 b.(Fig. 9 and Figure 10 are a) time, and flat 408 (described flat also is in primary importance place shown in Figure 11) do not contact any testing sensor in a plurality of testing sensors 14 when slider 406 is in the primary importance place.(referring to Figure 10 a), flat 408 (referring to Figure 11) also moves along direction of arrow B when direction of arrow B moves when slider 406.
Referring to Figure 13, there is shown flat 408 zoomed-in view before the testing sensor that will contact in the stacked testing sensor 14.In this embodiment, flat comprises gradually thin end 408a.Expect that flat 408 has gradually thin end 408a to help a releasing testing sensor from tube, prevents that simultaneously the next testing sensor in the stacked testing sensor from being removed simultaneously.The gradually thin end of conception can have the angle that is different from angle shown in Figure 13.
Return Fig. 9 and Figure 10 c, the outside of housing 404 has formed two external channels.Be easy to move in order to help slider, slider 406 shown in Figure 9 is illustrated along another external channel on external channel 412 and the opposite side and moves (referring to Figure 10 c).More specifically, shown in Figure 10 c, the hanging legs 406a of slider 406 extends in passage 412, and second hanging legs 406b extends in relative external channel.For the user can be easy to grip, slider 406 can form spine or sawtooth portion on its top surface, shown in Fig. 9 and Figure 10 c.
Be envisaged in the sensor-dispensing instrument and can use other slider.For example, sensor-dispensing instrument 450 as shown in figure 15 comprises pusher assembly 452, apparatus shell 454 and slider 456.Slider 456 only has a hanging legs 456a, and described hanging legs is bonded in the side channels.In this embodiment, apparatus shell 454 has formed an outside portion passage definitely and has moved between the position with guiding slider 456.
Figure 16 shows another embodiment of sensor-dispensing instrument 500, and described sensor-dispensing instrument comprises pusher assembly 502, apparatus shell 504 and slider 506.Pusher assembly 502 shown in Figure 16 comprises slider 506 and flat 508, and wherein slider 506 is attached to flat 508 by extension 506a.In this embodiment, apparatus shell 504 does not form the outside portion passage that the guiding slider moves between the primary importance and the second place.
Return Figure 10 c, flat 408 is positioned at inner passage 414, and described inner passage helps to help flat 408 and moves to the second place (Figure 12) from primary importance (Figure 11).Pusher assembly 402 comprises that also guide block 416 is to guarantee that further flat 408 is suitably being moved in the plane.414 lower surface moves guide block 416 along the inner passage.Similarly, slider 506 shown in Figure 16 comprises that also inner passage 514 and guide block 516 are to help mobile and to place flat 508.
According to a process, Figure 11 extends through opening 420 with flat 408 shown in Figure 12 and extends through dynamic seal 18b subsequently and contact a testing sensor (referring to Figure 12) in a plurality of testing sensors 14 subsequently.Opening 420 suitably makes flat 408 with respect to a testing sensor alignment in dynamic seal 18a, 18b and a plurality of testing sensor 14.When slider 406 continues when the direction of arrow B shown in Figure 10 a moves, flat 408 contact and promote a testing sensor in a plurality of testing sensors 14 by seal 18a.When slider 406 moved to the second place (referring to Figure 10 b), flat 408 testing sensor that continues to promote in a plurality of testing sensors 14 shown in Figure 12 exported 410 by distributing at least in part until sensor.
If electrochemical sensor is used in the sensor-dispensing instrument 400, then will a testing sensor in the testing sensor 14 suitably be located with respect to electric contact 434 by flat 408.In other words, flat 408 the push to test sensor arrived and make testing sensor 14 and electric contact 434 suitable positions aligning places.Conception electric contact 434 comprises a plurality of contacts that are placed with respect to testing sensor.The front end of sensor 14 receives the drop of blood that for example will test subsequently, analyzes by 434 pairs of blood of electric contact thus.Analysis result is presented on the LCD 440 of sensor-dispensing instrument shown in Figure 9 400 (this will discuss below in more detail) subsequently.Conception can be used the sensor such as the optical sensor of other type.
The test lead of sensor is suitable for being placed with the fluid sample of testing (for example whole blood sample) and contacts.Can produce whole blood sample by cutter sweep such as lancet.Can obtain whole blood sample by lancet, described lancet can separate maybe with sensor-dispensing instrument and can be integrated in the sensor-dispensing instrument.Cutter sweep can obtain blood by the finger that for example punctures the people.
According to a process, can make a testing sensor advance to the appropriate location by (a) to receive whole blood sample; (b) produce whole blood sample; And (c) testing sensor is contacted with whole blood sample, wherein blood is inhaled in the sensor by capillarity usually, and preparation whole blood sample and testing.
Sensor is typically provided with from the front end of sensor or test lead and extends to the biological sensing material that is arranged on the sensor or the capillary channel of reagent material.When the test lead of sensor was placed in the fluid (accumulating in the blood on the finger after for example puncturing finger), a part of fluid was inhaled in the capillary channel by capillarity.Fluid subsequently with sensor in reagent material generation chemical reaction, with electric signal that the blood sugar level in the blood tested of indication is provided and subsequently described electric signal is sent to electric assembly.
After finishing test, can from sensor-dispensing instrument 400, remove testing sensor by several different methods.In one embodiment, sensor-dispensing instrument can comprise ejecting mechanism 438, and described ejecting mechanism ejects used testing sensor from sensor-dispensing instrument.In this embodiment, testing sensor is released under stressing conditions.In another embodiment, can make testing sensor drop out sensor-dispensing instrument by discharging gripping, thereby eject testing sensor testing sensor by action of gravity.In yet another embodiment, also can manually from sensor-dispensing instrument, remove testing sensor.
As shown in figure 12, flat 408 extensible seal 18a that passes through when moving to second place place.Conceive flat 408 and when contacting and promoting a testing sensor, can only extend through seal 18b.In certain embodiments, for example shown in Figure 6, flat can not extend through any dynamic seal in the process that the push to test sensor arrives and exports by distribution to small part.
Return Figure 10 b, slider 406 moves to the primary importance shown in Figure 10 a from its second place in the direction of arrow C.Simultaneously, flat 408 is also moved to primary importance from its second place, causes flat 408 by seal 18a, 18b.When slider 406 and flat 408 were in the primary importance place, tube 10 was moistureproof and airtight substantially.The conception sensor-dispensing instrument can be automatically, for example in response to the pushing of button, starts slide mechanism.
Figure 14 shows each position of the slider 406 among each embodiment that can be used for sensor-dispensing instrument.Primary importance 406a as shown in the figure is identical in conjunction with the position shown in Fig. 9 and Figure 10 a with the front.Second place 406b as shown in the figure is identical in conjunction with the position shown in Figure 10 b with the front.Slider also is movable to other position to bring into play other function.For example, in Figure 14, slider can march to the 3rd position 406c.For the purpose of more clear,, only show the part of the slider that is in 406c place, the 3rd position among the figure though the slider of each position shown in Figure 14 is measure-alike.When tube 260 was loaded in the sensor-dispensing, the 3rd position 406c of slider can use with tube shown in Figure 6 260.Therefore, when slider returned primary importance 406a, flat 408 entered and can dispose tube 260 openend 270b to form the seal that cooperates.Slider can have the 4th position 406d that ejects testing sensor under the effect of power.For the purpose of more clear,, only show the part of the slider that is in 406d place, the 4th position among the figure though the slider of each position is measure-alike.The conception sensor-dispensing instrument can allow slider to move to the position of more or less departing from position shown in Figure 14.
In certain embodiments of the present invention, the spring (not shown) can be attached on the slider 406, and this will allow slider to return primary importance 406a from any other position.
Also can make for flat 408 by metal or polymeric material.Some non-limiting metal materials comprise stainless steel and have the bronze of suitable coating.The limiting examples of polymeric material comprises polycarbonate, acrylonitrile-butadiene-styrene (ABS), nylon, polypropylene or its combination.Can in polymeric material, add adjuvant to form flat.
Sensor-dispensing instrument 400 also comprises bar code reader 444 (referring to Figure 11 and Figure 12), and described reader is read the bar coded sticker that can dispose on the tube.Bar code reader 444 can determine information for example lot number and the calibration number.Sensor-dispensing instrument 400 generally includes microprocessor or similar device to handle and/or to be stored in the data that produce in the blood sugar test process.These data can be presented on the LCD 440 of sensor-dispensing instrument shown in Figure 9 400.
LCD 440 shows from test process and/or in response to the information of the signal input of the button groups on the sensor-dispensing instrument 400 442.For example, button groups can be depressed to look back and to check the result of the process of the test of front on LCD 400.
Button groups 442 comprises a plurality of independent button 442a, 442b, 442c, and described button is depressed and distributes the electron device of utensil 400 with operation sensor.Button also can be depressed to look back and to show the result of the process of the test of front on LCD 440.Button also can be used for being provided with and showing date and temporal information, and starts reminder alarm, and described reminder alarm reminds the user to implement test, for example blood sugar test according to scheduled plan.Button also can be used for some calibration process that start sensor distributes utensil 400.
The more displayable information of sensor-dispensing instrument comprise following message: the indication that battery indication, numeral show, the residue number of sensors is indicated, be written into wound packages in the sensor-dispensing instrument applies blood sample indication, temperature indication or its various combinations.
Sensor-dispensing instrument 400 also can comprise the opening that is used for the battery tray assembly.The battery tray assembly comprises the battery tray that wherein is provided with battery.The battery tray assembly is inserted in the opening in sensor-dispensing instrument 400 sidepieces.When being inserted into like this, battery provides electric power for the electron device in the utensil 400, and described electron device comprises the circuit on circuit board assemblies (not shown) and the LCD 400.
Optional embodiment A
A kind of tube disposed of using with sensor-dispensing instrument of being suitable for, the described tube of disposing comprises:
Form the housing that passes through at least one opening wherein;
Be stacked in a plurality of testing sensors in the described housing, described a plurality of testing sensors are suitable for helping at least a analyte of test;
Be suitable for promoting along first direction the mechanical mechanism of described a plurality of testing sensors, a testing sensor in described a plurality of testing sensors is placed to be ejected from described tube; With
A plurality of dynamic seal, described a plurality of dynamic seal is suitable for being in the close position the place, described at least one opening is sealed so that moistureproof and airtight substantially substantially tube is provided in the described a plurality of dynamic seal of described closed position, and a dynamic seal in described a plurality of dynamic seal is suitable for being shown in an open position the place, allows a testing sensor in described a plurality of testing sensor to move through described dynamic seal in the described dynamic seal of described open position.
Optional Embodiment B
According to the tube shown in the embodiment A, wherein said mechanical mechanism is a spring.
Optional Embodiment C
According to the tube shown in the embodiment A, wherein said housing has formed an opening definitely.
Optional embodiment D
According to the tube shown in the embodiment A, each dynamic seal in wherein said a plurality of dynamic seal is the duckbill seal.
Optional embodiment E
According to the tube shown in the embodiment A, each dynamic seal in wherein said a plurality of dynamic seal is a spring seals.
Optional embodiment F
According to the tube shown in the embodiment A, each dynamic seal in wherein said a plurality of dynamic seal is a hollow pipeline.
Optional embodiment G
According to the tube shown in the embodiment A, each dynamic seal in wherein said a plurality of dynamic seal is the seal that can pivot.
Optional embodiment H
According to the tube shown in the embodiment A, wherein said analyte is a glucose.
Optional example I
Tube according to shown in the embodiment A further comprises drying agent.
Optional embodiment J
According to the tube shown in the embodiment A, wherein said a plurality of sensors are electrochemical sensors.
Optional embodiment K
According to the tube shown in the embodiment A, wherein said a plurality of sensors are optical sensors.
Optional embodiment L
According to the tube shown in the embodiment A, wherein said tube comprises main housing portion and lid housing parts.
Optional embodiment M
According to the tube shown in the embodiment L, at least one in wherein said main housing portion and the described lid housing parts comprises at least one energy detector.
Optional embodiment N
According to the tube shown in the embodiment A, wherein said tube comprises otch.
Optional embodiment O
A kind of tube disposed of using with sensor-dispensing instrument of being suitable for, the described tube of disposing comprises:
Form the housing that passes through at least one opening wherein;
Be stacked in a plurality of testing sensors in the described housing, described a plurality of testing sensors are suitable for helping at least a analyte of test;
Be suitable for promoting along first direction the mechanical mechanism of described a plurality of testing sensors, a testing sensor in described a plurality of testing sensors is placed to be ejected from described tube; With
Dynamic seal, described dynamic seal is suitable for being in the close position the place, described at least one opening is sealed so that moistureproof and airtight substantially substantially tube is provided in the described dynamic seal of described closed position, described dynamic seal is suitable for being shown in an open position the place, allows a testing sensor in described a plurality of testing sensor to move through described dynamic seal in the described dynamic seal of described open position.
Optional embodiment P
A kind of sensor-dispensing instrument, described sensor-dispensing instrument comprises:
Can dispose tube, the described tube of disposing comprises the housing that forms at least one opening by wherein; Be stacked in a plurality of testing sensors in the described housing, described a plurality of testing sensors are suitable for helping at least a analyte of test; Be suitable for promoting along first direction the mechanical mechanism of described a plurality of testing sensors, a testing sensor in described a plurality of testing sensors is placed to be ejected from described tube; At least one dynamic seal, described at least one dynamic seal is suitable for being in the close position the place, described at least one opening is sealed so that moistureproof and airtight substantially substantially tube is provided in described at least one dynamic seal of described closed position, described at least one dynamic seal is suitable for being shown in an open position the place, allows a testing sensor in described a plurality of testing sensor to move through described at least one dynamic seal in described at least one dynamic seal of described open position;
Form and distribute outlet and be suitable for receiving the described housing of disposing tube; With
Pusher assembly, described pusher assembly comprise the slider that is attached to described pusher assembly and thin flat, and described flat is suitable for sliding to the second place from primary importance under the migration of described pusher assembly,
Wherein described flat from described primary importance to the process that the described second place moves, described flat contact in described a plurality of testing sensors a testing sensor and promote described testing sensor at least in part by at least one described dynamic seal.
Optional embodiment Q
According to the utensil shown in the embodiment P, wherein said sensor-dispensing instrument is a blood glucose meter.
Optional embodiment R
A kind of tube disposed of using with sensor-dispensing instrument of being suitable for, the described tube of disposing comprises:
Form the housing that passes through at least one opening wherein;
Be stacked in a plurality of testing sensors in the described housing, described a plurality of testing sensors are suitable for helping at least a analyte of test;
Mechanical mechanism, described mechanical mechanism are suitable for promoting described a plurality of testing sensor along first direction, so that a testing sensor in described a plurality of testing sensor is placed to be ejected from described tube, described mechanical mechanism comprises torsion spring; With
A plurality of dynamic seal, described a plurality of dynamic seal is suitable for being in the close position the place, described at least one opening is sealed so that moistureproof and airtight substantially substantially tube is provided in the described a plurality of dynamic seal of described closed position, and a dynamic seal in described a plurality of dynamic seal is suitable for being shown in an open position the place, allows a testing sensor in described a plurality of testing sensor to move through described dynamic seal in the described dynamic seal of described open position.
Optional embodiment S
According to the tube shown in the embodiment R, wherein said mechanical mechanism further comprises the activity pressure plate.
Optional embodiment T
According to the tube shown in the embodiment R, wherein said housing has formed an opening definitely.
Optional embodiment U
According to the tube shown in the embodiment R, each dynamic seal in wherein said a plurality of dynamic seal is the duckbill seal.
Optional EXAMPLE V
According to the tube shown in the embodiment R, wherein said analyte is a glucose.
Optional embodiment W
Tube according to shown in the embodiment R further comprises drying agent.
Optional embodiment X
According to the tube shown in the embodiment R, wherein said a plurality of sensors are electrochemical sensors.
Optional embodiment Y
According to the tube shown in the embodiment R, wherein said a plurality of sensors are optical sensors.
Optional embodiment Z
A kind of tube disposed of using with sensor-dispensing instrument of being suitable for, the described tube of disposing comprises:
Form the housing that passes through at least one opening wherein;
Be stacked in a plurality of testing sensors in the described housing, described a plurality of testing sensors are suitable for helping at least a analyte of test;
Mechanical mechanism, described mechanical mechanism are suitable for promoting described a plurality of testing sensor so that a testing sensor in described a plurality of testing sensor is placed to be ejected along first direction from described tube, and described mechanical mechanism comprises torsion spring; With
Dynamic seal, described dynamic seal is suitable for being in the close position the place, described at least one opening is sealed so that moistureproof and airtight substantially substantially tube is provided in the described dynamic seal of described closed position, described dynamic seal is suitable for being shown in an open position the place, allows a testing sensor in described a plurality of testing sensor to move through described dynamic seal in the described dynamic seal of described open position.
Optional embodiment A A
A kind of sensor-dispensing instrument, described sensor-dispensing instrument comprises:
Can dispose tube, the described tube of disposing comprises the housing that forms at least one opening by wherein; Be stacked in a plurality of testing sensors in the described housing, described a plurality of testing sensors are suitable for helping at least a analyte of test; Mechanical mechanism, described mechanical mechanism are suitable for promoting described a plurality of testing sensor along first direction, so that a testing sensor in described a plurality of testing sensor is placed to be ejected from described tube, described mechanical mechanism comprises torsion spring; At least one dynamic seal, described at least one dynamic seal is suitable for being in the close position the place, described at least one opening is sealed so that moistureproof and airtight substantially substantially tube is provided in described at least one dynamic seal of described closed position, described at least one dynamic seal is suitable for being shown in an open position the place, allows a testing sensor in described a plurality of testing sensor to move through described at least one dynamic seal in described at least one dynamic seal of described open position;
Form and distribute outlet and be suitable for receiving the described housing of disposing tube; With
Pusher assembly, described pusher assembly comprise the slider that is attached to described pusher assembly and thin flat, and described flat is suitable for sliding to the second place from primary importance under the migration of described pusher assembly,
Wherein described flat from described primary importance to the process that the described second place moves, described flat contact in described a plurality of testing sensors a testing sensor and promote described testing sensor at least in part by at least one described dynamic seal.
Optional Embodiment B B
According to the utensil shown in the embodiment A A, wherein said sensor-dispensing instrument is a blood glucose meter.
Although invention has been described in conjunction with the details of illustrated embodiment, these details are not intended to limit the scope of the present invention that claims limit.For example, sensor-dispensing instrument 400 can be used for testing the fluid except that blood sugar.In fact, sensor-dispensing instrument 400 can be used in combination with the analysis of the chemical fluid of any kind, can analyze described chemical fluid by reagent material.
Claims (28)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US58271204P | 2004-06-24 | 2004-06-24 | |
| US60/582,712 | 2004-06-24 | ||
| US60/617,825 | 2004-10-12 |
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| Publication Number | Publication Date |
|---|---|
| CN1985167A true CN1985167A (en) | 2007-06-20 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200580020839 Pending CN1985167A (en) | 2004-06-24 | 2005-06-23 | Cartridge and sensor-dispensing instrument |
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| Country | Link |
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| CN (1) | CN1985167A (en) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102460158A (en) * | 2009-06-05 | 2012-05-16 | 曼多公司 | Cassette for a body fluid measuring strip and body fluid measuring device |
| CN102667474A (en) * | 2009-08-20 | 2012-09-12 | 霍夫曼-拉罗奇有限公司 | Simplified magazining of integrated systems |
| CN103282122A (en) * | 2010-12-29 | 2013-09-04 | 雅培医护站股份有限公司 | Multi-fluid cartridges for sample analysis and methods of their use |
| CN103922042A (en) * | 2014-04-30 | 2014-07-16 | 王苗苗 | Semi-automatic blood glucose test paper box |
| CN108226384A (en) * | 2016-12-14 | 2018-06-29 | 盟立自动化股份有限公司 | Detection apparatus and organic compound detector |
| CN114778623A (en) * | 2022-04-28 | 2022-07-22 | 山东维璟医疗器械股份有限公司 | Test paper storehouse module for vitamin detector |
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2005
- 2005-06-23 CN CN 200580020839 patent/CN1985167A/en active Pending
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102460158A (en) * | 2009-06-05 | 2012-05-16 | 曼多公司 | Cassette for a body fluid measuring strip and body fluid measuring device |
| CN102460158B (en) * | 2009-06-05 | 2014-12-17 | 曼多公司 | Case and body fluid measuring device for body fluid measuring strip |
| US9081000B2 (en) | 2009-06-05 | 2015-07-14 | Mendor Oy | Cartridge for body fluid measuring strips and a body fluid measurement device |
| CN102667474A (en) * | 2009-08-20 | 2012-09-12 | 霍夫曼-拉罗奇有限公司 | Simplified magazining of integrated systems |
| US9528977B2 (en) | 2009-08-20 | 2016-12-27 | Roche Diabetes Care, Inc. | Simplified storage of at least one test element including a dry reagent layer having an enzyme and a stabilized coenzyme |
| CN103282122A (en) * | 2010-12-29 | 2013-09-04 | 雅培医护站股份有限公司 | Multi-fluid cartridges for sample analysis and methods of their use |
| CN103282122B (en) * | 2010-12-29 | 2016-03-16 | 雅培医护站股份有限公司 | Multi-fluid cartridges for sample analysis and methods of their use |
| US9770716B2 (en) | 2010-12-29 | 2017-09-26 | Abbott Point Of Care Inc. | Multi-fluidic cartridges for sample analysis and methods for using same |
| CN103922042A (en) * | 2014-04-30 | 2014-07-16 | 王苗苗 | Semi-automatic blood glucose test paper box |
| CN108226384A (en) * | 2016-12-14 | 2018-06-29 | 盟立自动化股份有限公司 | Detection apparatus and organic compound detector |
| CN114778623A (en) * | 2022-04-28 | 2022-07-22 | 山东维璟医疗器械股份有限公司 | Test paper storehouse module for vitamin detector |
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Open date: 20070620 |