CN1970032B - Chinese medicine containing honeysuckle flower and weeping forsythia for treating cold - Google Patents
Chinese medicine containing honeysuckle flower and weeping forsythia for treating cold Download PDFInfo
- Publication number
- CN1970032B CN1970032B CN2006101618308A CN200610161830A CN1970032B CN 1970032 B CN1970032 B CN 1970032B CN 2006101618308 A CN2006101618308 A CN 2006101618308A CN 200610161830 A CN200610161830 A CN 200610161830A CN 1970032 B CN1970032 B CN 1970032B
- Authority
- CN
- China
- Prior art keywords
- chinese medicine
- preparation
- standby
- hours
- volatile oil
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000003814 drug Substances 0.000 title claims description 74
- 241000205585 Aquilegia canadensis Species 0.000 title abstract 2
- 241000576429 Forsythia suspensa Species 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 claims abstract description 43
- XOJVHLIYNSOZOO-SWOBOCGESA-N Arctiin Chemical compound C1=C(OC)C(OC)=CC=C1C[C@@H]1[C@@H](CC=2C=C(OC)C(O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O3)O)=CC=2)C(=O)OC1 XOJVHLIYNSOZOO-SWOBOCGESA-N 0.000 claims abstract description 14
- 239000002775 capsule Substances 0.000 claims abstract description 8
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 89
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 64
- 239000000796 flavoring agent Substances 0.000 claims description 50
- 235000019634 flavors Nutrition 0.000 claims description 48
- 239000000341 volatile oil Substances 0.000 claims description 47
- 239000007788 liquid Substances 0.000 claims description 38
- 239000000706 filtrate Substances 0.000 claims description 34
- 239000000284 extract Substances 0.000 claims description 21
- 238000000034 method Methods 0.000 claims description 21
- 238000000605 extraction Methods 0.000 claims description 20
- 150000001875 compounds Chemical class 0.000 claims description 16
- 239000000843 powder Substances 0.000 claims description 14
- 241000628997 Flos Species 0.000 claims description 13
- 239000010231 banlangen Substances 0.000 claims description 13
- 238000004821 distillation Methods 0.000 claims description 11
- 239000008187 granular material Substances 0.000 claims description 11
- 238000001256 steam distillation Methods 0.000 claims description 11
- 239000003826 tablet Substances 0.000 claims description 11
- 239000000203 mixture Substances 0.000 claims description 10
- 239000003921 oil Substances 0.000 claims description 10
- 230000006837 decompression Effects 0.000 claims description 9
- 230000008569 process Effects 0.000 claims description 9
- 238000001694 spray drying Methods 0.000 claims description 9
- 238000003756 stirring Methods 0.000 claims description 9
- -1 suspensoid Substances 0.000 claims description 8
- 239000002994 raw material Substances 0.000 claims description 6
- 229920000858 Cyclodextrin Polymers 0.000 claims description 5
- 239000000470 constituent Substances 0.000 claims description 5
- 239000001116 FEMA 4028 Substances 0.000 claims description 4
- WHGYBXFWUBPSRW-FOUAGVGXSA-N beta-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO WHGYBXFWUBPSRW-FOUAGVGXSA-N 0.000 claims description 4
- 235000011175 beta-cyclodextrine Nutrition 0.000 claims description 4
- 229960004853 betadex Drugs 0.000 claims description 4
- 238000001035 drying Methods 0.000 claims description 4
- 239000002674 ointment Substances 0.000 claims description 4
- 239000006187 pill Substances 0.000 claims description 3
- 231100000614 poison Toxicity 0.000 claims description 3
- 239000003440 toxic substance Substances 0.000 claims description 3
- 239000012141 concentrate Substances 0.000 claims description 2
- 239000000825 pharmaceutical preparation Substances 0.000 claims description 2
- 239000000829 suppository Substances 0.000 claims description 2
- 238000004064 recycling Methods 0.000 claims 1
- 235000008216 herbs Nutrition 0.000 abstract description 2
- 241000206501 Actaea <angiosperm> Species 0.000 abstract 1
- 241000605447 Anemarrhena Species 0.000 abstract 1
- 241000208843 Arctium Species 0.000 abstract 1
- 241000931705 Cicada Species 0.000 abstract 1
- 235000014435 Mentha Nutrition 0.000 abstract 1
- 241001072983 Mentha Species 0.000 abstract 1
- 244000046146 Pueraria lobata Species 0.000 abstract 1
- 235000010575 Pueraria lobata Nutrition 0.000 abstract 1
- 229930191283 anemarrhena Natural products 0.000 abstract 1
- 235000013399 edible fruits Nutrition 0.000 abstract 1
- 239000009792 yinqiao Substances 0.000 description 38
- 229940079593 drug Drugs 0.000 description 23
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 16
- 239000000243 solution Substances 0.000 description 14
- 241000699666 Mus <mouse, genus> Species 0.000 description 10
- 238000012360 testing method Methods 0.000 description 10
- 241000699670 Mus sp. Species 0.000 description 9
- 229920002472 Starch Polymers 0.000 description 9
- 230000000694 effects Effects 0.000 description 9
- 239000004615 ingredient Substances 0.000 description 9
- 235000019698 starch Nutrition 0.000 description 9
- 239000008107 starch Substances 0.000 description 9
- 229940032147 starch Drugs 0.000 description 9
- 229930006000 Sucrose Natural products 0.000 description 8
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 8
- 238000007908 dry granulation Methods 0.000 description 8
- 235000019359 magnesium stearate Nutrition 0.000 description 8
- 239000000463 material Substances 0.000 description 8
- 235000019198 oils Nutrition 0.000 description 8
- 238000012856 packing Methods 0.000 description 8
- 239000005720 sucrose Substances 0.000 description 8
- 239000013543 active substance Substances 0.000 description 7
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 7
- 239000012567 medical material Substances 0.000 description 7
- 238000002156 mixing Methods 0.000 description 7
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 6
- 229920000168 Microcrystalline cellulose Polymers 0.000 description 6
- 239000003795 chemical substances by application Substances 0.000 description 6
- 239000002552 dosage form Substances 0.000 description 6
- 238000002474 experimental method Methods 0.000 description 6
- 235000019813 microcrystalline cellulose Nutrition 0.000 description 6
- 239000008108 microcrystalline cellulose Substances 0.000 description 6
- 229940016286 microcrystalline cellulose Drugs 0.000 description 6
- 241000191967 Staphylococcus aureus Species 0.000 description 5
- 241000193998 Streptococcus pneumoniae Species 0.000 description 5
- 239000002671 adjuvant Substances 0.000 description 5
- 201000010099 disease Diseases 0.000 description 5
- 206010022000 influenza Diseases 0.000 description 5
- 230000004083 survival effect Effects 0.000 description 5
- 241000713196 Influenza B virus Species 0.000 description 4
- 208000002193 Pain Diseases 0.000 description 4
- 241000700605 Viruses Species 0.000 description 4
- 230000000202 analgesic effect Effects 0.000 description 4
- 230000003110 anti-inflammatory effect Effects 0.000 description 4
- 208000015181 infectious disease Diseases 0.000 description 4
- 238000011835 investigation Methods 0.000 description 4
- 210000004072 lung Anatomy 0.000 description 4
- 230000036407 pain Effects 0.000 description 4
- 238000010992 reflux Methods 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 3
- 241000588724 Escherichia coli Species 0.000 description 3
- 229930195725 Mannitol Natural products 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- 239000011248 coating agent Substances 0.000 description 3
- 238000000576 coating method Methods 0.000 description 3
- 230000000857 drug effect Effects 0.000 description 3
- 150000002148 esters Chemical class 0.000 description 3
- 239000000945 filler Substances 0.000 description 3
- 229930003944 flavone Natural products 0.000 description 3
- 150000002213 flavones Chemical class 0.000 description 3
- 235000011949 flavones Nutrition 0.000 description 3
- 239000000594 mannitol Substances 0.000 description 3
- 235000010355 mannitol Nutrition 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 238000001556 precipitation Methods 0.000 description 3
- 238000011160 research Methods 0.000 description 3
- 230000008961 swelling Effects 0.000 description 3
- 230000001225 therapeutic effect Effects 0.000 description 3
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 2
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 2
- PZIRUHCJZBGLDY-UHFFFAOYSA-N Caffeoylquinic acid Natural products CC(CCC(=O)C(C)C1C(=O)CC2C3CC(O)C4CC(O)CCC4(C)C3CCC12C)C(=O)O PZIRUHCJZBGLDY-UHFFFAOYSA-N 0.000 description 2
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
- 206010011224 Cough Diseases 0.000 description 2
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 2
- 241000721047 Danaus plexippus Species 0.000 description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- 108010010803 Gelatin Proteins 0.000 description 2
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 2
- 206010019233 Headaches Diseases 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 2
- CTQNGGLPUBDAKN-UHFFFAOYSA-N O-Xylene Chemical compound CC1=CC=CC=C1C CTQNGGLPUBDAKN-UHFFFAOYSA-N 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 description 2
- 206010036790 Productive cough Diseases 0.000 description 2
- RXUWDKBZZLIASQ-UHFFFAOYSA-N Puerarin Natural products OCC1OC(Oc2c(O)cc(O)c3C(=O)C(=COc23)c4ccc(O)cc4)C(O)C(O)C1O RXUWDKBZZLIASQ-UHFFFAOYSA-N 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 241000191940 Staphylococcus Species 0.000 description 2
- 241000191963 Staphylococcus epidermidis Species 0.000 description 2
- 208000005946 Xerostomia Diseases 0.000 description 2
- 231100000215 acute (single dose) toxicity testing Toxicity 0.000 description 2
- 238000011047 acute toxicity test Methods 0.000 description 2
- 229930013930 alkaloid Natural products 0.000 description 2
- 229940024606 amino acid Drugs 0.000 description 2
- 235000001014 amino acid Nutrition 0.000 description 2
- 150000001413 amino acids Chemical class 0.000 description 2
- 230000002421 anti-septic effect Effects 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- 235000010980 cellulose Nutrition 0.000 description 2
- 229920002678 cellulose Polymers 0.000 description 2
- 239000001913 cellulose Substances 0.000 description 2
- 239000003086 colorant Substances 0.000 description 2
- 206010013781 dry mouth Diseases 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 235000019197 fats Nutrition 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 235000013355 food flavoring agent Nutrition 0.000 description 2
- 238000003304 gavage Methods 0.000 description 2
- 239000008273 gelatin Substances 0.000 description 2
- 229920000159 gelatin Polymers 0.000 description 2
- 235000019322 gelatine Nutrition 0.000 description 2
- 235000011852 gelatine desserts Nutrition 0.000 description 2
- 235000011187 glycerol Nutrition 0.000 description 2
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 2
- 239000010931 gold Substances 0.000 description 2
- 229910052737 gold Inorganic materials 0.000 description 2
- 231100000869 headache Toxicity 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 238000000338 in vitro Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000008101 lactose Substances 0.000 description 2
- 239000000314 lubricant Substances 0.000 description 2
- 201000009240 nasopharyngitis Diseases 0.000 description 2
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 2
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 2
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 2
- 239000002244 precipitate Substances 0.000 description 2
- HKEAFJYKMMKDOR-VPRICQMDSA-N puerarin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1C1=C(O)C=CC(C2=O)=C1OC=C2C1=CC=C(O)C=C1 HKEAFJYKMMKDOR-VPRICQMDSA-N 0.000 description 2
- 230000002685 pulmonary effect Effects 0.000 description 2
- 238000012216 screening Methods 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- GEHJYWRUCIMESM-UHFFFAOYSA-L sodium sulfite Chemical compound [Na+].[Na+].[O-]S([O-])=O GEHJYWRUCIMESM-UHFFFAOYSA-L 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 235000010356 sorbitol Nutrition 0.000 description 2
- 239000000600 sorbitol Substances 0.000 description 2
- 230000001629 suppression Effects 0.000 description 2
- 208000011580 syndromic disease Diseases 0.000 description 2
- 239000006188 syrup Substances 0.000 description 2
- 235000020357 syrup Nutrition 0.000 description 2
- 230000009885 systemic effect Effects 0.000 description 2
- 239000010409 thin film Substances 0.000 description 2
- 239000000080 wetting agent Substances 0.000 description 2
- QIJRTFXNRTXDIP-UHFFFAOYSA-N (1-carboxy-2-sulfanylethyl)azanium;chloride;hydrate Chemical compound O.Cl.SCC(N)C(O)=O QIJRTFXNRTXDIP-UHFFFAOYSA-N 0.000 description 1
- CWVRJTMFETXNAD-BMNNCGMMSA-N (1s,3r,4s,5r)-3-[(e)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxy-1,4,5-trihydroxycyclohexane-1-carboxylic acid Chemical compound O[C@H]1[C@H](O)C[C@@](O)(C(O)=O)C[C@H]1OC(=O)\C=C\C1=CC=C(O)C(O)=C1 CWVRJTMFETXNAD-BMNNCGMMSA-N 0.000 description 1
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 1
- OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 description 1
- CWVRJTMFETXNAD-FWCWNIRPSA-N 3-O-Caffeoylquinic acid Natural products O[C@H]1[C@@H](O)C[C@@](O)(C(O)=O)C[C@H]1OC(=O)\C=C\C1=CC=C(O)C(O)=C1 CWVRJTMFETXNAD-FWCWNIRPSA-N 0.000 description 1
- CYDQOEWLBCCFJZ-UHFFFAOYSA-N 4-(4-fluorophenyl)oxane-4-carboxylic acid Chemical compound C=1C=C(F)C=CC=1C1(C(=O)O)CCOCC1 CYDQOEWLBCCFJZ-UHFFFAOYSA-N 0.000 description 1
- LXAHHHIGZXPRKQ-UHFFFAOYSA-N 5-fluoro-2-methylpyridine Chemical compound CC1=CC=C(F)C=N1 LXAHHHIGZXPRKQ-UHFFFAOYSA-N 0.000 description 1
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 description 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
- 229920001817 Agar Polymers 0.000 description 1
- 235000019489 Almond oil Nutrition 0.000 description 1
- 239000005995 Aluminium silicate Substances 0.000 description 1
- 241000193830 Bacillus <bacterium> Species 0.000 description 1
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
- 229920002307 Dextran Polymers 0.000 description 1
- KFFCKOBAHMGTMW-LGQRSHAYSA-N Forsythin Chemical compound C1=C(OC)C(OC)=CC=C1[C@H]1[C@@H](CO[C@@H]2C=3C=C(OC)C(O[C@H]4[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O4)O)=CC=3)[C@@H]2CO1 KFFCKOBAHMGTMW-LGQRSHAYSA-N 0.000 description 1
- 229930091371 Fructose Natural products 0.000 description 1
- 239000005715 Fructose Substances 0.000 description 1
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 239000004471 Glycine Substances 0.000 description 1
- 239000004354 Hydroxyethyl cellulose Substances 0.000 description 1
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 description 1
- 241000712431 Influenza A virus Species 0.000 description 1
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 description 1
- GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 description 1
- 229920000881 Modified starch Polymers 0.000 description 1
- 206010028748 Nasal obstruction Diseases 0.000 description 1
- CWVRJTMFETXNAD-KLZCAUPSSA-N Neochlorogenin-saeure Natural products O[C@H]1C[C@@](O)(C[C@@H](OC(=O)C=Cc2ccc(O)c(O)c2)[C@@H]1O)C(=O)O CWVRJTMFETXNAD-KLZCAUPSSA-N 0.000 description 1
- 241001597008 Nomeidae Species 0.000 description 1
- 206010068319 Oropharyngeal pain Diseases 0.000 description 1
- 241000283973 Oryctolagus cuniculus Species 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 208000000114 Pain Threshold Diseases 0.000 description 1
- 201000007100 Pharyngitis Diseases 0.000 description 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Natural products OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 1
- JJVGFDTWFVSBIM-UHFFFAOYSA-N Phillyrin Natural products COc1ccc(cc1OC)C2OCC3C2COC3c4ccc(OC)c(OC5OC(CO)C(O)C(O)C5O)c4 JJVGFDTWFVSBIM-UHFFFAOYSA-N 0.000 description 1
- 206010035733 Pneumonia salmonella Diseases 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 241000588769 Proteus <enterobacteria> Species 0.000 description 1
- 206010039101 Rhinorrhoea Diseases 0.000 description 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 1
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 1
- 239000004141 Sodium laurylsulphate Substances 0.000 description 1
- NWGKJDSIEKMTRX-AAZCQSIUSA-N Sorbitan monooleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O NWGKJDSIEKMTRX-AAZCQSIUSA-N 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 1
- 229930003268 Vitamin C Natural products 0.000 description 1
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 description 1
- 210000000683 abdominal cavity Anatomy 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 235000010489 acacia gum Nutrition 0.000 description 1
- 239000001785 acacia senegal l. willd gum Substances 0.000 description 1
- 235000011054 acetic acid Nutrition 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 102000011759 adducin Human genes 0.000 description 1
- 108010076723 adducin Proteins 0.000 description 1
- 239000008272 agar Substances 0.000 description 1
- 229940072056 alginate Drugs 0.000 description 1
- 235000010443 alginic acid Nutrition 0.000 description 1
- 229920000615 alginic acid Polymers 0.000 description 1
- 229910000288 alkali metal carbonate Inorganic materials 0.000 description 1
- 150000008041 alkali metal carbonates Chemical class 0.000 description 1
- 239000008168 almond oil Substances 0.000 description 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 1
- 235000012211 aluminium silicate Nutrition 0.000 description 1
- CEGOLXSVJUTHNZ-UHFFFAOYSA-K aluminium tristearate Chemical compound [Al+3].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O CEGOLXSVJUTHNZ-UHFFFAOYSA-K 0.000 description 1
- 239000003708 ampul Substances 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000000845 anti-microbial effect Effects 0.000 description 1
- 230000000840 anti-viral effect Effects 0.000 description 1
- 239000008365 aqueous carrier Substances 0.000 description 1
- 239000006286 aqueous extract Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- GUBGYTABKSRVRQ-QUYVBRFLSA-N beta-maltose Chemical compound OC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@@H]1O GUBGYTABKSRVRQ-QUYVBRFLSA-N 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 230000036760 body temperature Effects 0.000 description 1
- NKWPZUCBCARRDP-UHFFFAOYSA-L calcium bicarbonate Chemical compound [Ca+2].OC([O-])=O.OC([O-])=O NKWPZUCBCARRDP-UHFFFAOYSA-L 0.000 description 1
- 229910000020 calcium bicarbonate Inorganic materials 0.000 description 1
- 229910000019 calcium carbonate Inorganic materials 0.000 description 1
- CJZGTCYPCWQAJB-UHFFFAOYSA-L calcium stearate Chemical compound [Ca+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O CJZGTCYPCWQAJB-UHFFFAOYSA-L 0.000 description 1
- 239000008116 calcium stearate Substances 0.000 description 1
- 235000013539 calcium stearate Nutrition 0.000 description 1
- 239000001768 carboxy methyl cellulose Substances 0.000 description 1
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 1
- 229940126678 chinese medicines Drugs 0.000 description 1
- 229940074393 chlorogenic acid Drugs 0.000 description 1
- CWVRJTMFETXNAD-JUHZACGLSA-N chlorogenic acid Chemical compound O[C@@H]1[C@H](O)C[C@@](O)(C(O)=O)C[C@H]1OC(=O)\C=C\C1=CC=C(O)C(O)=C1 CWVRJTMFETXNAD-JUHZACGLSA-N 0.000 description 1
- FFQSDFBBSXGVKF-KHSQJDLVSA-N chlorogenic acid Natural products O[C@@H]1C[C@](O)(C[C@@H](CC(=O)C=Cc2ccc(O)c(O)c2)[C@@H]1O)C(=O)O FFQSDFBBSXGVKF-KHSQJDLVSA-N 0.000 description 1
- 235000001368 chlorogenic acid Nutrition 0.000 description 1
- 238000004587 chromatography analysis Methods 0.000 description 1
- BMRSEYFENKXDIS-KLZCAUPSSA-N cis-3-O-p-coumaroylquinic acid Natural products O[C@H]1C[C@@](O)(C[C@@H](OC(=O)C=Cc2ccc(O)cc2)[C@@H]1O)C(=O)O BMRSEYFENKXDIS-KLZCAUPSSA-N 0.000 description 1
- 239000003240 coconut oil Substances 0.000 description 1
- 235000019864 coconut oil Nutrition 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 235000008504 concentrate Nutrition 0.000 description 1
- 239000004567 concrete Substances 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 229960001305 cysteine hydrochloride Drugs 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- FPAFDBFIGPHWGO-UHFFFAOYSA-N dioxosilane;oxomagnesium;hydrate Chemical compound O.[Mg]=O.[Mg]=O.[Mg]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O FPAFDBFIGPHWGO-UHFFFAOYSA-N 0.000 description 1
- 239000008298 dragée Substances 0.000 description 1
- 239000006196 drop Substances 0.000 description 1
- 239000008157 edible vegetable oil Substances 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 239000002158 endotoxin Substances 0.000 description 1
- 239000002662 enteric coated tablet Substances 0.000 description 1
- 238000012869 ethanol precipitation Methods 0.000 description 1
- BEFDCLMNVWHSGT-UHFFFAOYSA-N ethenylcyclopentane Chemical compound C=CC1CCCC1 BEFDCLMNVWHSGT-UHFFFAOYSA-N 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 239000007941 film coated tablet Substances 0.000 description 1
- 238000009501 film coating Methods 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 238000007710 freezing Methods 0.000 description 1
- 230000008014 freezing Effects 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 238000001879 gelation Methods 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 238000000227 grinding Methods 0.000 description 1
- 239000007902 hard capsule Substances 0.000 description 1
- 235000011167 hydrochloric acid Nutrition 0.000 description 1
- 238000005984 hydrogenation reaction Methods 0.000 description 1
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 description 1
- 229940071826 hydroxyethyl cellulose Drugs 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- KRZBCHWVBQOTNZ-DLDRDHNVSA-N isochlorogenic acid Natural products O[C@@H]1[C@H](C[C@@](O)(C[C@H]1OC(=O)C=Cc2ccc(O)c(O)c2)C(=O)O)OC(=O)C=Cc3ccc(O)c(O)c3 KRZBCHWVBQOTNZ-DLDRDHNVSA-N 0.000 description 1
- FZWBNHMXJMCXLU-BLAUPYHCSA-N isomaltotriose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@@H](OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O)O1 FZWBNHMXJMCXLU-BLAUPYHCSA-N 0.000 description 1
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 1
- 150000002576 ketones Chemical class 0.000 description 1
- 238000009533 lab test Methods 0.000 description 1
- 238000011031 large-scale manufacturing process Methods 0.000 description 1
- 239000000787 lecithin Substances 0.000 description 1
- 235000010445 lecithin Nutrition 0.000 description 1
- 229940067606 lecithin Drugs 0.000 description 1
- 239000003589 local anesthetic agent Substances 0.000 description 1
- 229940057948 magnesium stearate Drugs 0.000 description 1
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 1
- 229930182817 methionine Natural products 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- 235000010981 methylcellulose Nutrition 0.000 description 1
- 239000001923 methylcellulose Substances 0.000 description 1
- 235000019426 modified starch Nutrition 0.000 description 1
- 239000010413 mother solution Substances 0.000 description 1
- 238000000465 moulding Methods 0.000 description 1
- 208000010753 nasal discharge Diseases 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 230000037040 pain threshold Effects 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000008506 pathogenesis Effects 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 238000005325 percolation Methods 0.000 description 1
- 239000000575 pesticide Substances 0.000 description 1
- 239000003208 petroleum Substances 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 230000003285 pharmacodynamic effect Effects 0.000 description 1
- 229960003742 phenol Drugs 0.000 description 1
- 235000009048 phenolic acids Nutrition 0.000 description 1
- 150000007965 phenolic acids Chemical class 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 150000003904 phospholipids Chemical class 0.000 description 1
- 235000011007 phosphoric acid Nutrition 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 239000011505 plaster Substances 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 239000001103 potassium chloride Substances 0.000 description 1
- 235000011164 potassium chloride Nutrition 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 description 1
- 239000004405 propyl p-hydroxybenzoate Substances 0.000 description 1
- QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 235000018102 proteins Nutrition 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 238000010926 purge Methods 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 238000005057 refrigeration Methods 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 150000003376 silicon Chemical class 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 235000002639 sodium chloride Nutrition 0.000 description 1
- HRZFUMHJMZEROT-UHFFFAOYSA-L sodium disulfite Chemical compound [Na+].[Na+].[O-]S(=O)S([O-])(=O)=O HRZFUMHJMZEROT-UHFFFAOYSA-L 0.000 description 1
- 239000001540 sodium lactate Substances 0.000 description 1
- 229940005581 sodium lactate Drugs 0.000 description 1
- 235000011088 sodium lactate Nutrition 0.000 description 1
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 1
- 235000010262 sodium metabisulphite Nutrition 0.000 description 1
- 229940080313 sodium starch Drugs 0.000 description 1
- 235000010265 sodium sulphite Nutrition 0.000 description 1
- AKHNMLFCWUSKQB-UHFFFAOYSA-L sodium thiosulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=S AKHNMLFCWUSKQB-UHFFFAOYSA-L 0.000 description 1
- 235000019345 sodium thiosulphate Nutrition 0.000 description 1
- 239000007901 soft capsule Substances 0.000 description 1
- 239000002689 soil Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 235000010199 sorbic acid Nutrition 0.000 description 1
- 239000004334 sorbic acid Substances 0.000 description 1
- 229940075582 sorbic acid Drugs 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 229930002600 steroidal saponin Natural products 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 229960004793 sucrose Drugs 0.000 description 1
- 239000007940 sugar coated tablet Substances 0.000 description 1
- 239000001117 sulphuric acid Substances 0.000 description 1
- 235000011149 sulphuric acid Nutrition 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 239000000375 suspending agent Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 235000018553 tannin Nutrition 0.000 description 1
- 239000001648 tannin Substances 0.000 description 1
- 229920001864 tannin Polymers 0.000 description 1
- ZAVXXBAIPSQJGS-UHFFFAOYSA-B tetracalcium;tetrasodium;2-[2-[bis(carboxylatomethyl)amino]ethyl-(carboxylatomethyl)amino]acetate Chemical compound [Na+].[Na+].[Na+].[Na+].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]C(=O)CN(CC([O-])=O)CCN(CC([O-])=O)CC([O-])=O.[O-]C(=O)CN(CC([O-])=O)CCN(CC([O-])=O)CC([O-])=O.[O-]C(=O)CN(CC([O-])=O)CCN(CC([O-])=O)CC([O-])=O ZAVXXBAIPSQJGS-UHFFFAOYSA-B 0.000 description 1
- 150000003648 triterpenes Chemical class 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
- 238000010792 warming Methods 0.000 description 1
- 238000005550 wet granulation Methods 0.000 description 1
- 239000000811 xylitol Substances 0.000 description 1
- 235000010447 xylitol Nutrition 0.000 description 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
- 229960002675 xylitol Drugs 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention relates to a Chinese medicinal preparation which is prepared from Chinese medicinal herbs including honeysuckle flower, kudzu vine root, capsule of weeping forsythia, arctium fruit, mentha, isatic root, anemarrhena rhizome, cimicifuga rhizome, cicada shell.
Description
Technical field:
The present invention relates to a kind of YINQIAO Chinese medicine preparation that relieves internal heat, particularly use Flos Lonicerae, Radix Puerariae, Fructus Forsythiae, Fructus Arctii, Herba Menthae, Radix Isatidis, the Rhizoma Anemarrhenae, Rhizoma Cimicifugae, the Chinese medicine preparation that Chinese medicines such as Periostracum Cicadae are made.
Background technology:
Prescription of the present invention system sums up in recent years on the empirical basis of tcm clinical, to the cause of disease, pathogenesis and the method for treatment of catching a cold and the progress of clinical application, carries out the clinical experience side of prescription in conjunction with Chinese medicine in recent years by the principles of formulating prescriptions of present science of TCM formulas.The present invention's prescription is made up of Flos Lonicerae, Radix Puerariae, Fructus Arctii, Periostracum Cicadae, Fructus Forsythiae, Radix Isatidis etc., and the main effect in full side is: dispelling wind and heat pathogens, relieving the exterior syndrome with drugs of pungent in flavor and cool in nature, heat-clearing and toxic substances removing, pathogenic fire purging sore-throat relieving.Be used for anemopyretic common cold and influenza.It is clinical in showing as: heating, headache, systemic pain, cough, expectoration, xerostomia and thirsty, diseases such as red swelling and pain of throat.
The present invention has overcome the defective of prior art, and a kind of determined curative effect, safe ready, little, the cheap pure traditional Chinese compound medicine of side effect are provided.
Summary of the invention:
The invention provides a kind of YINQIAO Chinese medicine preparation that relieves internal heat, its function cures mainly and is relieving the exterior syndrome with drugs of pungent in flavor and cool in nature, heat-clearing and toxic substances removing.Be used for anemopyretic common cold and influenza, disease is seen heating, headache, systemic pain, and nasal obstruction, watery nasal discharge, cough, expectoration, throat is itched, xerostomia and thirsty, red swelling and pain of throat, red tongue, diseases such as rapid pulse.
Chinese medicine preparation of the present invention, its prescription is composed as follows:
Flos Lonicerae 100-400g Radix Puerariae 75-300g Fructus Forsythiae 100-400g Fructus Arctii 60-240g
Herba Menthae 60-240g Radix Isatidis 60-240g Rhizoma Anemarrhenae 75-300g Rhizoma Cimicifugae 50-200g
Periostracum Cicadae 30-120g
Most preferred prescription is composed as follows:
Flos Lonicerae 200g Radix Puerariae 150g Fructus Forsythiae 200g Fructus Arctii 120g
Herba Menthae 120g Radix Isatidis 120g Rhizoma Anemarrhenae 150g Rhizoma Cimicifugae 100g
Periostracum Cicadae 60g
In more than forming, weight is calculated with crude drug, more than form to can be made into 1000 doses of pharmaceutical preparatioies, and described 1000 doses of fingers, the final drug preparation of making, as make 1000 of capsule preparations, 1000 in tablet, granule 1000 grams, oral liquid 1000ml etc.
More than form, as if being unit with the gram, can be made into the preparation of 50-1000 taking dose, as tablet, make 1000, each taking dose can be the 1-20 sheet, can take 50-1000 time altogether.As granule, make 125 bags, take the 1-2 bag at every turn, can take 62.5-125 time altogether.
More than form to be by weight as proportioning, when producing, can increase or reduce according to corresponding proportion, as large-scale production can be unit with the kilogram, or be unit with the ton, small-scale production can be unit with the milligram also, weight can increase or reduce, but the constant rate of the raw medicinal herbs weight proportion between each composition.
The ratio of above weight proportion obtains through science screening, for especial patient, and as serious symptom or light disease, fat or modest patient, the proportioning of the amount of can corresponding adjustment forming increases or reduces being no more than 100%, and drug effect is constant.
Single medicinal material, especially ministerial drug and adjuvant drug in more than forming also can be replaced by the suitable Chinese medicine with identical property of medicine, and its drug effect of the Chinese medicine preparation after the replacement is constant.
Chinese medicine preparation of the present invention is to process through extraction or other modes by the raw material of Chinese medicine that above-mentioned prescription is formed, and makes pharmaceutically active substance, subsequently, with this material is raw material, adds the medicine acceptable carrier when needing, and makes according to the routine techniques of galenic pharmacy.Described active substance can obtain by extracting raw material of Chinese medicine respectively, also can obtain by the co-extracted raw material of Chinese medicine, also can obtain by other modes, as: by pulverize, squeeze, calcine, grind, sieve, percolation, extraction, water are carried, alcohol extraction, ester are carried, methods such as ketone is carried, chromatography obtain, these active substances can be the material of extractum form, can be that dry extract also can be a fluid extract, make different concentration according to the different needs decision of preparation.
Pharmaceutically active substance in the Chinese medicine preparation of the present invention, its shared percentage by weight in preparation can be 0.1-99.9%, all the other are the medicine acceptable carrier.Pharmaceutical preparation of the present invention exists with unit dosage form, and described unit dosage form is meant the unit of preparation, as every of tablet, and capsular every capsules, every bottle of oral liquid, every bag of granule etc.
Chinese medicine preparation of the present invention can be any pharmaceutically useful dosage form, and these dosage forms comprise: tablet, sugar coated tablet, film coated tablet, enteric coated tablet, capsule, hard capsule, soft capsule, oral liquid, suck agent, granule, electuary, pill, powder, unguentum, sublimed preparation, suspensoid, powder, solution, injection, suppository, ointment, plaster, cream, spray, drop, patch.Preparation of the present invention, peroral dosage form preferably, as: capsule, tablet, oral liquid, granule, pill, powder, sublimed preparation, unguentum etc.Tablet most preferably.
Chinese medicine preparation of the present invention, the preparation of its oral administration can contain excipient commonly used, such as binding agent, filler, diluent, tablet agent, lubricant, disintegrating agent, coloring agent, flavoring agent and wetting agent, can carry out coating to tablet in case of necessity.
The filler that is suitable for comprises cellulose, mannitol, lactose and other similar filler.Suitable disintegrating agent comprises starch, polyvinylpyrrolidone and starch derivatives, for example sodium starch glycollate.Suitable lubricant comprises, for example magnesium stearate.The acceptable wetting agent of appropriate drug comprises sodium lauryl sulphate.
Can fill by mixing, the method that tabletting etc. are commonly used prepares solid oral composition.Mix repeatedly active substance is distributed in those compositionss of a large amount of filleies of whole use.
The form of oral liquid for example can be aqueous or oily suspensions, solution, Emulsion, syrup or elixir, perhaps can be a kind of available water before use or other suitable composite dry products of carrier.This liquid preparation can contain conventional additive, such as suspending agent, for example sorbitol, syrup, methylcellulose, gelatin, hydroxyethyl-cellulose, carboxymethyl cellulose, aluminium stearate gel or hydrogenation edible fat, emulsifying agent, for example lecithin, anhydro sorbitol monooleate or arabic gum; Non-aqueous carrier (they can comprise edible oil), for example almond oil, fractionated coconut oil, such as oily ester, propylene glycol or the ethanol of the ester of glycerol; Antiseptic, for example para hydroxybenzene methyl ester or propyl p-hydroxybenzoate or sorbic acid, and if desired, can contain conventional flavouring agent or coloring agent.
For injection, the liquid unit dosage forms of preparation contains active substance of the present invention and sterile carrier.According to carrier and concentration, this chemical compound can be suspended or dissolving.The preparation of solution is normally by being dissolved in active substance in a kind of carrier filter-sterilized before it is packed into a kind of suitable bottle or ampoule, sealing then.For example a kind of local anesthetic of adjuvant, antiseptic and buffer agent also can be dissolved in this carrier.In order to improve its stability, can be after the bottle of packing into that this compositions is freezing, and under vacuum, water is removed.
Chinese medicine preparation of the present invention, when being prepared into medicament, optionally add suitable medicine acceptable carrier, described medicine acceptable carrier is selected from: mannitol, sorbitol, sodium pyrosulfite, sodium sulfite, sodium thiosulfate, cysteine hydrochloride, TGA, methionine, vitamin C, the EDTA disodium, EDTA calcium sodium, the alkali-metal carbonate of monovalence, acetate, phosphate or its aqueous solution, hydrochloric acid, acetic acid, sulphuric acid, phosphoric acid, aminoacid, sodium chloride, potassium chloride, sodium lactate, xylitol, maltose, glucose, fructose, dextran, glycine, starch, sucrose, lactose, mannitol, silicon derivative, cellulose and derivant thereof, alginate, gelatin, polyvinylpyrrolidone, glycerol, soil temperature 80, agar, calcium carbonate, calcium bicarbonate, surfactant, Polyethylene Glycol, cyclodextrin, beta-schardinger dextrin-, the phospholipid material, Kaolin, Pulvis Talci, calcium stearate, magnesium stearate etc.
Preparation of the present invention is determined usage and dosage according to patient's situation in use, but obeys every day three times, each 1-20 agent, as: 1-20 bag or grain or sheet.
Chinese medicine preparation preferred manufacturing procedure of the present invention is as follows:
Fructus Forsythiae, Herba Menthae two flavors, steam distillation extracts volatile oil, and gained volatile oil gets clathrate with beta-cyclodextrin inclusion compound, and extracting solution filters, and is standby; Carry oil back medicinal residues extracting in water, filter, filtrate and vapor distillation extracting solution merge, and be standby;
All the other seven flavors decoct with water, and extracting solution concentrates, and put coldly, add ethanol, leave standstill, and filter, and reclaim ethanol, drying, dry powder, add above-mentioned volatile oil clathrate compound, obtain active constituents of medicine; This composition mixes separately or with the medicine acceptable carrier, makes Chinese medicine preparation of the present invention according to the galenic pharmacy routine techniques.
Concrete grammar is:
In the prescription nine flavor medicine, Fructus Forsythiae, Herba Menthae two flavors add 10 times of water gagings, and steam distillation extracts volatile oil, and 3.0 hours extraction times, extracting solution filters, and is standby; Gained volatile oil was measured 60 ℃ of enclose of beta-schardinger dextrin-3.0 hours with 8 times, got clathrate, and is standby; Carry oil back medicinal residues and add 8 times of water gagings, extracted 2.0 hours, filter, filtrate and vapor distillation medicinal liquid merge, and be standby; Radix Puerariae etc. seven flavor decocts with water twice, and each 2.0 hours, 11 times of water gagings for the first time, 10 times of water gagings for the second time, decocting liquid filters, and filtrate merges, and is standby; Merge above twice filtrate, being evaporated to relative density is 1.07～1.09 (60 ℃), puts and is chilled to room temperature, slowly adding ethanol makes and contains alcohol amount and reach 70%, fully stir, left standstill 18 hours, filter, filtrate decompression (0.085Mpa, 70～80 ℃) reclaim ethanol to there not being the alcohol flavor, the medicinal liquid thin up is to relative density 1.03～1.05 (20 ℃), spray drying, get dry powder, add above-mentioned volatile oil clathrate compound, obtain active constituents of medicine; This composition mixes separately or with the medicine acceptable carrier, makes Chinese medicine preparation of the present invention according to the galenic pharmacy routine techniques.
As preparation for tablet, can adopt above active component, add starch, sucrose, magnesium stearate and microcrystalline Cellulose, mixing, dry granulation, dry, granulate, tabletting, the bag film-coat, packing, promptly.
Extraction process of the present invention obtains through screening, in order to reduce oral dose, improves clinical efficacy, and we divide into groups medical material according to the physicochemical property of each medical material effective ingredient, and every group is carried out Study on extraction process respectively.
(1) the effective ingredient type of seven flavor medicine material such as Radix Puerariae is many, and the polarity scope is big, but most of known effective ingredient is water solublity, as the flavones ingredient in the monarch drug Radix Puerariae; Known content reaches 6.6% antimicrobial component chlorogenic acid, isochlorogenic acid in the monarch drug Flos Lonicerae; Steroidal saponin in the ministerial drug Rhizoma Anemarrhenae, organic acid, alkaloids and flavones ingredient; The decocting liquid tool antiinflammatory action of adjuvant drug Fructus Arctii, the decocting liquid tool bacteriostasis of Radix Isatidis, the triterpenes in the Rhizoma Cimicifugae, phenolic acids, alkaloids and flavones ingredient, the amino acids composition in the Periostracum Cicadae; In sum, more than the most water soluble of main effective ingredient of each flavour of a drug, therefore can adopt water is that solvent extracts.
In extraction process by water research, be index with the puerarin rate of transform, amount of water, extraction time, extraction time three factors have been carried out the orthogonal experiment investigation.The result shows that optimised process is: the extraction process of seven flavor medicine materials such as Radix Puerariae is: medical material adds 11 times of water gagings, and reflux, extract, 2.0 hours filters, and medicinal residues add 10 times of water gagings again, and reflux, extract, 2.0 hours filters, and the water extract merges; Medicinal liquid is standby.
(2) Fructus Forsythiae, Herba Menthae are respectively ministerial drug and adjuvant drug in this prescription, and two flavor medical materials mainly contain aqueous soluble active constituent [3], effects such as according to the literature, that the Fructus Forsythiae decocting liquid has is analgesic, antiinflammatory, and the Herba Menthae decocting liquid has antiviral, effect such as antibiotic; And Fructus Forsythiae, Herba Menthae two flavor medical materials all contain volatile oil component, and volatile oil has certain drug effect; Adopt steam distillation, collect volatile oil, not only extracted effective ingredient, and kept volatile oil; Volatile oil adopts beta-cyclodextrin inclusion compound, guarantees the content of volatile oil in preparation.
This part is at first carried out volatile oil and is extracted prerun, determines extraction time and amount of water that volatile oil extracts, investigates through parallel laboratory test, is defined as: 10 times of water gagings, distillation time 3 hours.
Inclusion essential oil experiment serves as to investigate index with clathrate yield and inclusion essential oil rate, and influence factors such as beta-schardinger dextrin-and volatile oil proportioning, enclose temperature, enclose time have been carried out the orthogonal experiment investigation.The result shows that optimised process is: get the beta-schardinger dextrin-of 8 times of amounts of volatile oil, add in the entry, be warming up to 60 ℃ and make saturated aqueous solution, slowly drip volatile oil under 100r/min stirs, added behind the volatile oil 60 ℃ of insulated and stirred 3 hours; 4 ℃ of cold preservation 12 hours is filtered, and with a small amount of petroleum ether filtering residue, twice gained precipitation merges, drying at room temperature, and grinding promptly gets the white powder clathrate.
In extraction process by water research, be index with the phillyrin rate of transform, to solvent multiple, extraction times two factor carried out the orthogonal experiment investigation.The result shows that optimised process is: medical material adds 10 times of amounts of water for the first time, and reflux, extract, 3.0 hours is collected volatile oil simultaneously, filters, and medicinal residues add 8 times of amounts of water again, and reflux, extract, 2.0 hours filters, and the water extract merges, and is standby.
(3) above-mentioned aqueous extract contains impurity such as medicinal residues, tannin, protein, starch, phlegmatic temperament and resin, gets content in order to improve effective ingredient, selects for use ethanol precipitation that the water extract is carried out purification (making with extra care), and method is simple for this, process stabilizing.
In alcohol precipitation process research, be index with the puerarin rate of transform, concentrated solution relative concentration, alcohol precipitation concentration, precipitate with ethanol times three factor have been carried out the orthogonal experiment investigation.The result shows that optimised process is: two groups of water of medical material are guided and supported merging, are concentrated into to contain crude drug 1.0g/ml, add 95% ethanol to containing alcohol amount 70%, place 18 hours, filter, and get alcohol deposit fluid, and are standby.
(4) after the precipitate with ethanol mother solution filters,, decompression (0.085Mpa), advanced technologies such as low temperature (＜80 ℃) thin film concentration and spray drying have been adopted in order to reduce loss of active ingredients in concentrated and the drying process.
(5) dry granulation is compared with wet granulation, have to shorten man-hour, reduce production costs, wet, heat-labile medicine is destroyed advantages such as little, still adopt dry granulation.
(6) above-mentioned medicinal liquid, spray drying is made dry powder, with the volatile oil mix homogeneously of beta-cyclodextrin inclusion compound, further adds the adjuvant of tablet molding again, after granulating, is pressed into plain sheet.
(7) for the moisture absorption that solves plain sheet and the loss problem of volatile oil, we have adopted the thin film coating material of Shanghai Colorcon Coating Technology Co., Ltd---Opadry, select for use moistureproof film-coat material to carry out coating.
Below by pharmacodynamics test beneficial effect of the present invention is described.
The experiment medicine is the medicine of the embodiment of the invention 1 method preparation, at this called after: the YINQIAO sheet that relieves internal heat.
The test of pesticide effectiveness
1, extracorporeal bacteria inhibitor test [1] test tube method: the YINQIAO sheet that relieves internal heat has bacteriostasis preferably to clinical separation Diplococcus pneumoniae, staphylococcus epidermidis, staphylococcus aureus, escherichia coli, Bacillus proteus, MIC is at 25mg (crude drug, down with)/ml-100mg/ml between, prompting: the YINQIAO sheet that relieves internal heat has the good in-vitro bacteriostasis.[2] flat band method: YINQIAO relieves internal heat sheet to standard gold Staphylococcus aureus, escherichia coli, clinical SEPARATION OF GOLD Staphylococcus aureus, Diplococcus pneumoniae, staphylococcus epidermidis, escherichia coli, section have bacteriostasis preferably for staphylococcus, kerekou pneumonia Salmonella, dissolving staphylococcal bacteria, middle staphylococcus, MIC is between 50mg/ml-100mg/ml, and prompting: the YINQIAO sheet that relieves internal heat has the good in-vitro bacteriostasis.
2, antibacterial tests in the body: [1] YINQIAO heavy dose of group of sheet that relieves internal heat can reduce infection of staphylococcus aureus dead mouse number, but not statistically significant.Can prolong the survival natural law of infecting mouse; Relatively have significant difference (P＜0.05) with model group, prompting: the YINQIAO sheet that relieves internal heat has the certain protection effect to the infection of staphylococcus aureus mice.[2] relieve internal heat dosage group and heavy dose of group in the sheet of YINQIAO can obviously improve the survival rate of infecting mouse to the Diplococcus pneumoniae infecting mouse; and can prolong the survival natural law of Diplococcus pneumoniae infecting mouse; relatively have significant difference (P＜0.05) with model group, prompting: the YINQIAO sheet that relieves internal heat has the better protect effect to the Diplococcus pneumoniae infecting mouse.
3, interior resisting virus test shows: relieve internal heat in sheet dosage group and heavy dose of group of [1] YINQIAO can obviously prolong influenza a virus infection mice survival natural law, relatively has significant difference (P＜0.05) with the virus control group.Three dosage groups all can reduce the infecting mouse mortality rate.But not statistically significant.Prompting: the YINQIAO sheet that relieves internal heat has the certain protection effect to the influenza a virus infection mice.[2] relieve internal heat dosage group and heavy dose of group of lung exponential quantity that can obviously reduce the influenza a virus infection mice in the sheet of YINQIAO, with virus control group tool significant difference (P＜0.05) relatively, lung index suppression ratio is respectively 19.56% and 23.81%.Prompting: the YINQIAO sheet that relieves internal heat has certain therapeutical effect to pulmonary infection disease due to the influenza A virus.[3] the YINQIAO heavy dose of group of sheet that relieves internal heat can obviously prolong Influenza B virus infecting mouse survival natural law; reduce death toll; relatively have significant difference (P＜0.05) prompting with the virus control group: the YINQIAO sheet that relieves internal heat has the better protect effect to the Influenza B virus infecting mouse.[4] the YINQIAO heavy dose of group of sheet that relieves internal heat can obviously reduce the lung exponential quantity of Influenza B virus infecting mouse, lung index suppression ratio 33.1%.Prompting: the YINQIAO sheet that relieves internal heat has certain therapeutical effect to pulmonary infection disease due to the Influenza B virus.
4. the antiinflammatory result of the test shows: 1. YINQIAO relieve internal heat sheet little, in, can reduce auricle swelling degree due to the dimethylbenzene greatly, with model group notable difference (P＜0.05, P＜0.01) is arranged relatively.2. YINQIAO relieves internal heat in the sheet, can reduce the optical density value of abdominal cavity eluate greatly, with model group notable difference (P＜0.05, P＜0.01) is arranged relatively, prompting: the YINQIAO sheet that relieves internal heat has certain antiinflammatory action.
5. analgesic result of the test shows: 1. YINQIAO relieve internal heat sheet little, in, big three dosage groups can reduce that rat temperature raises due to the dry yeast, with model group notable difference (P＜0.05) are arranged relatively.2. YINQIAO relieve internal heat sheet little, in, big two dosage groups can reduce that rabbit body temperature raises due to the endotoxin, with model group notable difference (P＜0.05, P＜0.01) are arranged relatively.Prompting: the YINQIAO sheet that relieves internal heat has certain refrigeration function.
6. the analgesic test result shows: 1. YINQIAO relieve internal heat sheet little, in, big three dosage group Dichlorodiphenyl Acetate induced mice writhing responses do not have obvious protective effect, with model group relatively (P＞0.05).2. YINQIAO relieve internal heat sheet little, in, big three dosage groups do not have obvious influence to the pain threshold of mice, with model group relatively (P＞0.05).The prompting YINQIAO relieves internal heat sheet to chemical, the no obvious analgesic activity of physical property stimulation.
Acute toxicity test
The maximum dosage-feeding test of oral administration has been carried out in acute toxicity test to mice and rat.The result shows: the abnormal conditions that there is no mice and rat after administration take place.The clinical adult one consumption per day 15g/60kg of sheet if YINQIAO relieves internal heat (press the crude drug amount and calculate, down together), then: 1. the mice maximum dosage-feeding of twice oral administration gavage administration is 561.6g/kg in one day, is 2246 times of clinical adult's one consumption per day; 2. the rat maximum dosage-feeding of twice oral administration gavage administration is 351g/kg in one day, is 1404 times of clinical adult's one consumption per day.
Show that the YINQIAO sheet oral administration degree of safety that relieves internal heat is bigger.
In sum: the YINQIAO of the present invention preparation that relieves internal heat has therapeutical effect preferably.
The specific embodiment:
Further specify the present invention by the following examples, but not as limitation of the present invention.
Embodiment 1
Flos Lonicerae 200g Radix Puerariae 150g Fructus Forsythiae 200g Fructus Arctii 120g
Herba Menthae 120g Radix Isatidis 120g Rhizoma Anemarrhenae 150g Rhizoma Cimicifugae 100g
Periostracum Cicadae 60g
Above flavour of a drug are made relieve internal heat 1000 of sheets of YINQIAO.
More than nine flavors, Fructus Forsythiae, Herba Menthae two flavors add 10 times of water gagings, steam distillation extracts volatile oil, 3.0 hours extraction times, extracting solution filters, and is standby; Gained volatile oil was measured 60 ℃ of enclose of beta-schardinger dextrin-3.0 hours with 8 times, got clathrate, and is standby; Carry oil back medicinal residues and add 8 times of water gagings, extracted 2.0 hours, filter, filtrate and vapor distillation medicinal liquid merge, and be standby; Radix Puerariae etc. seven flavor decocts with water twice, and each 2.0 hours, 11 times of water gagings for the first time, 10 times of water gagings for the second time, decocting liquid filters, and filtrate merges, and is standby; Merge above twice filtrate, being evaporated to relative density is 1.07～1.09 (60 ℃), puts and is chilled to room temperature, slowly adding ethanol makes and contains alcohol amount and reach 70%, fully stir, left standstill 18 hours, filter, filtrate decompression (0.085Mpa, 70～80 ℃) reclaim ethanol to there not being the alcohol flavor, the medicinal liquid thin up is to relative density 1.03～1.05 (20 ℃), spray drying, get dry powder, add above-mentioned volatile oil clathrate compound, starch, sucrose, an amount of magnesium stearate and microcrystalline Cellulose, mixing, dry granulation, dry, granulate, tabletting, bag film-coat, packing, promptly.
Embodiment 2
Flos Lonicerae 100g Radix Puerariae 75g Fructus Forsythiae 100g Fructus Arctii 60g
Herba Menthae 60g Radix Isatidis 60g Rhizoma Anemarrhenae 75g Rhizoma Cimicifugae 50g
Periostracum Cicadae 30g
Above flavour of a drug are made relieve internal heat 1000 of sheets of YINQIAO.
More than nine flavors, Fructus Forsythiae, Herba Menthae two flavors add 10 times of water gagings, steam distillation extracts volatile oil, 3.0 hours extraction times, extracting solution filters, and is standby; Gained volatile oil was measured 60 ℃ of enclose of beta-schardinger dextrin-3.0 hours with 8 times, got clathrate, and is standby; Carry oil back medicinal residues and add 8 times of water gagings, extracted 2.0 hours, filter, filtrate and vapor distillation medicinal liquid merge, and be standby; Radix Puerariae etc. seven flavor decocts with water twice, and each 2.0 hours, 11 times of water gagings for the first time, 10 times of water gagings for the second time, decocting liquid filters, and filtrate merges, and is standby; Merge above twice filtrate, being evaporated to relative density is 1.07～1.09 (60 ℃), puts and is chilled to room temperature, slowly adding ethanol makes and contains alcohol amount and reach 70%, fully stir, left standstill 18 hours, filter, filtrate decompression (0.085Mpa, 70～80 ℃) reclaim ethanol to there not being the alcohol flavor, the medicinal liquid thin up is to relative density 1.03～1.05 (20 ℃), spray drying, get dry powder, add above-mentioned volatile oil clathrate compound, starch, sucrose, an amount of magnesium stearate and microcrystalline Cellulose, mixing, dry granulation, dry, granulate, tabletting, bag film-coat, packing, promptly.
Embodiment 3
Flos Lonicerae 400g Radix Puerariae 300g Fructus Forsythiae 400g Fructus Arctii 240g
Herba Menthae 240g Radix Isatidis 240g Rhizoma Anemarrhenae 300g Rhizoma Cimicifugae 200g
Periostracum Cicadae 120g
Above flavour of a drug are made relieve internal heat 1000 of sheets of YINQIAO.
More than nine flavors, Fructus Forsythiae, Herba Menthae two flavors add 10 times of water gagings, steam distillation extracts volatile oil, 3.0 hours extraction times, extracting solution filters, and is standby; Gained volatile oil was measured 60 ℃ of enclose of beta-schardinger dextrin-3.0 hours with 8 times, got clathrate, and is standby; Carry oil back medicinal residues and add 8 times of water gagings, extracted 2.0 hours, filter, filtrate and vapor distillation medicinal liquid merge, and be standby; Radix Puerariae etc. seven flavor decocts with water twice, and each 2.0 hours, 11 times of water gagings for the first time, 10 times of water gagings for the second time, decocting liquid filters, and filtrate merges, and is standby; Merge above twice filtrate, being evaporated to relative density is 1.07～1.09 (60 ℃), puts and is chilled to room temperature, slowly adding ethanol makes and contains alcohol amount and reach 70%, fully stir, left standstill 18 hours, filter, filtrate decompression (0.085Mpa, 70～80 ℃) reclaim ethanol to there not being the alcohol flavor, the medicinal liquid thin up is to relative density 1.03～1.05 (20 ℃), spray drying, get dry powder, add above-mentioned volatile oil clathrate compound, starch, sucrose, an amount of magnesium stearate and microcrystalline Cellulose, mixing, dry granulation, dry, granulate, tabletting, bag film-coat, packing, promptly.
Embodiment 4
Flos Lonicerae 200g Radix Puerariae 150g Fructus Forsythiae 200g Fructus Arctii 120g
Herba Menthae 120g Radix Isatidis 120g Rhizoma Anemarrhenae 150g Rhizoma Cimicifugae 100g
Periostracum Cicadae 60g
Above flavour of a drug are made relieve internal heat 1000 of capsules of YINQIAO.
More than nine flavors, Fructus Forsythiae, Herba Menthae two flavors add 10 times of water gagings, steam distillation extracts volatile oil, 3.0 hours extraction times, extracting solution filters, and is standby; Gained volatile oil was measured 60 ℃ of enclose of beta-schardinger dextrin-3.0 hours with 8 times, got clathrate, and is standby; Carry oil back medicinal residues and add 8 times of water gagings, extracted 2.0 hours, filter, filtrate and vapor distillation medicinal liquid merge, and be standby; Radix Puerariae etc. seven flavor decocts with water twice, and each 2.0 hours, 11 times of water gagings for the first time, 10 times of water gagings for the second time, decocting liquid filters, and filtrate merges, and is standby; Merge above twice filtrate, being evaporated to relative density is 1.07～1.09 (60 ℃), put and be chilled to room temperature, slowly add ethanol and make and contain alcohol amount and reach 70%, fully stir, left standstill 18 hours, filter, filtrate decompression (0.085Mpa, 70～80 ℃) reclaims ethanol to there not being the alcohol flavor, and the medicinal liquid thin up is to relative density 1.03～1.05 (20 ℃), spray drying, get dry powder, add above-mentioned volatile oil clathrate compound, starch, sucrose, an amount of magnesium stearate and microcrystalline Cellulose, mixing, dry granulation, No. 1 capsule of packing, promptly.
Embodiment 5
Flos Lonicerae 200g Radix Puerariae 150g Fructus Forsythiae 200g Fructus Arctii 120g
Herba Menthae 120g Radix Isatidis 120g Rhizoma Anemarrhenae 150g Rhizoma Cimicifugae 100g
Periostracum Cicadae 60g
Above flavour of a drug are made the YINQIAO granule 1000g that relieves internal heat.
More than nine flavors, Fructus Forsythiae, Herba Menthae two flavors add 10 times of water gagings, steam distillation extracts volatile oil, 3.0 hours extraction times, extracting solution filters, and is standby; Gained volatile oil was measured 60 ℃ of enclose of beta-schardinger dextrin-3.0 hours with 8 times, got clathrate, and is standby; Carry oil back medicinal residues and add 8 times of water gagings, extracted 2.0 hours, filter, filtrate and vapor distillation medicinal liquid merge, and be standby; Radix Puerariae etc. seven flavor decocts with water twice, and each 2.0 hours, 11 times of water gagings for the first time, 10 times of water gagings for the second time, decocting liquid filters, and filtrate merges, and is standby; Merge above twice filtrate, being evaporated to relative density is 1.07～1.09 (60 ℃), put and be chilled to room temperature, slowly add ethanol and make and contain alcohol amount and reach 70%, fully stir, left standstill 18 hours, filter, filtrate decompression (0.085Mpa, 70～80 ℃) reclaims ethanol to there not being the alcohol flavor, and the medicinal liquid thin up is to relative density 1.03～1.05 (20 ℃), spray drying, get dry powder, add above-mentioned volatile oil clathrate compound, starch, sucrose, an amount of magnesium stearate and microcrystalline Cellulose, mixing, dry granulation, packing, promptly.
Embodiment 6
Flos Lonicerae 200g Radix Puerariae 150g Fructus Forsythiae 200g Fructus Arctii 120g
Herba Menthae 120g Radix Isatidis 120g Rhizoma Anemarrhenae 150g Rhizoma Cimicifugae 100g
Periostracum Cicadae 60g
Above flavour of a drug are made the YINQIAO oral liquid 1000ml that relieves internal heat.
More than nine flavors, Fructus Forsythiae, Herba Menthae two flavors add 10 times of water gagings, steam distillation extracts volatile oil, 3.0 hours extraction times, extracting solution filters, and is standby; Gained volatile oil was measured 60 ℃ of enclose of beta-schardinger dextrin-3.0 hours with 8 times, got clathrate, and is standby; Carry oil back medicinal residues and add 8 times of water gagings, extracted 2.0 hours, filter, filtrate and vapor distillation medicinal liquid merge, and be standby; Radix Puerariae etc. seven flavor decocts with water twice, and each 2.0 hours, 11 times of water gagings for the first time, 10 times of water gagings for the second time, decocting liquid filters, and filtrate merges, and is standby; Merge above twice filtrate, being evaporated to relative density is 1.07～1.09 (60 ℃), puts and is chilled to room temperature, slowly add ethanol and make and contain alcohol amount and reach 70%, fully stir, left standstill 18 hours, filter, filtrate decompression (0.085Mpa, 70～80 ℃) reclaims ethanol to there not being the alcohol flavor, and the medicinal liquid thin up is to relative density 1.03～1.05 (20 ℃), add above-mentioned volatile oil clathrate compound, sucrose, water is to 1000ml, packing, promptly.
Claims (7)
1. a heat-clearing and detoxifying herb preparation is characterized in that, is made by following raw material of Chinese medicine
Flos Lonicerae 100-400g Radix Puerariae 75-300g Fructus Forsythiae 100-400g Fructus Arctii 60-240g
Herba Menthae 60-240g Radix Isatidis 60-240g Rhizoma Anemarrhenae 75-300g Rhizoma Cimicifugae 50-200g
Periostracum Cicadae 30-120g.
2. the Chinese medicine preparation of claim 1 is characterized in that, is made by following raw material of Chinese medicine
Flos Lonicerae 200g Radix Puerariae 150g Fructus Forsythiae 200g Fructus Arctii 120g
Herba Menthae 120g Radix Isatidis 120g Rhizoma Anemarrhenae 150g Rhizoma Cimicifugae 100g
Periostracum Cicadae 60g.
3. the Chinese medicine preparation of claim 1 is characterized in that, is selected from tablet, capsule, granule, pill, unguentum, suspensoid, solution, suppository or patch.
4. the Chinese medicine preparation of claim 1 is a tablet.
5. the preparation method of the Chinese medicine preparation of claim 1 is characterized in that, the process following steps:
Fructus Forsythiae, Herba Menthae two flavors, steam distillation extracts volatile oil, and gained volatile oil gets clathrate with beta-cyclodextrin inclusion compound, and extracting solution filters, and is standby; Carry oil back medicinal residues extracting in water, filter, filtrate and vapor distillation extracting solution merge, and be standby;
All the other seven flavors decoct with water, and extracting solution concentrates, and put coldly, add ethanol, leave standstill, and filter, and reclaim ethanol, drying, dry powder, add above-mentioned volatile oil clathrate compound, obtain active constituents of medicine; This composition mixes separately or with the medicine acceptable carrier, makes Chinese medicine preparation of the present invention according to the galenic pharmacy routine techniques.
6. the preparation method of the Chinese medicine preparation of claim 5 is characterized in that, the process following steps:
Fructus Forsythiae, Herba Menthae two flavors add 10 times of water gagings, and steam distillation extracts volatile oil, and 3.0 hours extraction times, extracting solution filters, and is standby; Gained volatile oil was measured 60 ℃ of enclose of beta-schardinger dextrin-3.0 hours with 8 times, got clathrate, and is standby; Carry oil back medicinal residues and add 8 times of water gagings, extracted 2.0 hours, filter, filtrate and vapor distillation medicinal liquid merge, and be standby; Radix Puerariae etc. seven flavor decocts with water twice, and each 2.0 hours, 11 times of water gagings for the first time, 10 times of water gagings for the second time, decocting liquid filters, and filtrate merges, and is standby; Merge above twice filtrate, being evaporated to relative density is 1.07～1.09, puts and is chilled to room temperature, slowly adds ethanol and makes and contain alcohol amount and reach 70%, fully stir, left standstill 18 hours, and filtered, decompression filtrate recycling ethanol is to there not being the alcohol flavor, the medicinal liquid thin up is to relative density 1.03～1.05, spray drying gets dry powder, adds above-mentioned volatile oil clathrate compound, obtains active constituents of medicine; This composition mixes separately or with the medicine acceptable carrier, makes Chinese medicine preparation according to the galenic pharmacy routine techniques.
7. the application of the pharmaceutical preparation of claim 1 in preparation heat-clearing and toxic substances removing medicine.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2006101618308A CN1970032B (en) | 2006-12-05 | 2006-12-05 | Chinese medicine containing honeysuckle flower and weeping forsythia for treating cold |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2006101618308A CN1970032B (en) | 2006-12-05 | 2006-12-05 | Chinese medicine containing honeysuckle flower and weeping forsythia for treating cold |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1970032A CN1970032A (en) | 2007-05-30 |
| CN1970032B true CN1970032B (en) | 2011-07-20 |
Family
ID=38111180
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2006101618308A Active CN1970032B (en) | 2006-12-05 | 2006-12-05 | Chinese medicine containing honeysuckle flower and weeping forsythia for treating cold |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1970032B (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101361895B (en) * | 2008-08-23 | 2010-10-13 | 宫兆荣 | Traditional Chinese medicine combination for treating measles complicated pneumonia |
| CN106118867A (en) * | 2016-07-21 | 2016-11-16 | 桐城市佳明农业发展有限公司 | A kind of anti-Oleum Helianthi and preparation method thereof of getting angry |
| CN106074908A (en) * | 2016-07-30 | 2016-11-09 | 南京正宽医药科技有限公司 | A kind of ventilating nasal patch |
| CN106138835A (en) * | 2016-08-22 | 2016-11-23 | 黄平学 | The preparation method of the oral liquid that treatment heat-damp in summer sexuality emits |
| CN107929494A (en) * | 2018-01-02 | 2018-04-20 | 威海惠高生物科技有限公司 | It is a kind of to be used to treat Chinese medicine composition of abscess of throat and preparation method thereof |
| CN110801486B (en) * | 2019-11-14 | 2021-12-21 | 广州中医药大学(广州中医药研究院) | Traditional Chinese medicine compound preparation and preparation method and application thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1107057A (en) * | 1994-08-16 | 1995-08-23 | 欧致新 | Children coryza medicine and preparing method |
| CN1380098A (en) * | 2002-05-20 | 2002-11-20 | 张勇飞 | Anti-infection compound preparation and its preparation method |
-
2006
- 2006-12-05 CN CN2006101618308A patent/CN1970032B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1107057A (en) * | 1994-08-16 | 1995-08-23 | 欧致新 | Children coryza medicine and preparing method |
| CN1380098A (en) * | 2002-05-20 | 2002-11-20 | 张勇飞 | Anti-infection compound preparation and its preparation method |
Non-Patent Citations (3)
| Title |
|---|
| 付小菊 等."超滤法和水醇法制备清热解毒口服液的研究".《中国药学杂志》.1998, |
| 汤乃泓 等."抗感解毒颗粒剂的研制".《现代应用药学》.1995, |
| 苏明廉."第三讲 清热药的功效特点和应用".《山东中医杂志》.1982, |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1970032A (en) | 2007-05-30 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102430090A (en) | Traditional Tibetan medicine Ruyizhenbao composite preparation and preparation method thereof | |
| CN103405536A (en) | Chinese herbal veterinary drug used for treating diarrhoea and preparation method thereof | |
| CN101708241B (en) | Medicinal composition for eliminating dampness and relieving itching | |
| CN104887952B (en) | A composition with the effect of nourishing yin and moistening the lung and its preparation method and application | |
| CN100486635C (en) | Pharyngitis treating Chinese medicine | |
| CN1970032B (en) | Chinese medicine containing honeysuckle flower and weeping forsythia for treating cold | |
| CN102106965B (en) | Composition for treating acute injury of soft tissue and application thereof | |
| CN102357176B (en) | Anti-cold traditional Chinese medicine composition | |
| KR20130130580A (en) | Composition for preventing or treating gout containing mixed medicinal herbs extracts and method of preparing the extracts | |
| CN100353968C (en) | Chinese medicine preparation for nourishing blood and tranquilizing mind and its preparation process | |
| CN1943734B (en) | A Chinese traditional medicine for clearing away heat and toxic material | |
| CN1679689B (en) | Heat-clearing and toxicity-relieving Chinese medicine preparation and production thereof | |
| CN1278709C (en) | Medicine for treating cold and its preparing process | |
| CN101396435A (en) | Traditional Chinese medicine for treating gastrosis and preparation method and use thereof | |
| CN1709454A (en) | Chinese medicine formulation for treating arthrolithiasis, and its preparing method | |
| CN108125237B (en) | Health product for relieving cough, eliminating phlegm and resisting inflammation and preparation process thereof | |
| CN1943706B (en) | A Chinese traditional medicine for clearing away heat and expelling toxin | |
| CN100333744C (en) | Acne treating medicine | |
| CN1931229B (en) | Medicine for treating acute and chronic nasopharyngitis and its preparation process | |
| CN100335083C (en) | Pile treating Chinese medicine prepn and its production process | |
| CN119215089B (en) | Traditional Chinese medicine composition for clearing heat and detoxicating, resisting inflammation and reducing swelling, and preparation method and application thereof | |
| CN101607009B (en) | A pharmaceutical composition for treating common cold | |
| CN101574454B (en) | Rehabilitation reconstruction traditional Chinese medicine | |
| CN104547099B (en) | It is a kind of with cough-relieving, the preparation of resolving sputum function and preparation method thereof | |
| CN113521206B (en) | Traditional Chinese medicine composition containing burdock |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| TR01 | Transfer of patent right | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20200509 Address after: 222047 Jiangning economic and Technological Development Zone, Jiangsu, Lianyungang industrial city Patentee after: JIANGSU KANION PHARMACEUTICAL Co.,Ltd. Address before: 100070, room 1, building 2, 5358 Fu Heng street, Fengtai District Science Town, Beijing, China Patentee before: BEIJING TIANLI ZHENGYUAN MEDICINE TECHNOLOGY DEVELOPMENT Ltd. |