CN1961957A - Anti-aging colon absorption preparation - Google Patents
Anti-aging colon absorption preparation Download PDFInfo
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- CN1961957A CN1961957A CN 200510015983 CN200510015983A CN1961957A CN 1961957 A CN1961957 A CN 1961957A CN 200510015983 CN200510015983 CN 200510015983 CN 200510015983 A CN200510015983 A CN 200510015983A CN 1961957 A CN1961957 A CN 1961957A
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- chitosan
- calcium
- vitamin
- absorption preparation
- aging
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- 238000010521 absorption reaction Methods 0.000 title claims abstract description 93
- 238000002360 preparation method Methods 0.000 title claims description 90
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- 229920001661 Chitosan Polymers 0.000 claims abstract description 126
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims abstract description 100
- 102000008186 Collagen Human genes 0.000 claims abstract description 70
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- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims abstract description 68
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- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims abstract description 34
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- Medicinal Preparation (AREA)
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Abstract
The invention discloses an antisenescence colon absorbing agent comprising the following constituents (by weight percent): collagen powder 30-80%, grape seed extract 1-10%, vitamin C 1-20%, vitamin E 0-20%, calcium carbonate or calcium acetate or calcium gluconae or sclerotin calcium phosphate silicate or amino acid chelated calcium or calcium lactate or calcium citrate 0-50%, chitosan or chitosan salts or chitosan derivatives 9-15%, crystalline cellulose or sodium carboxymethylstarch or low substituted methylcellulose propylene glycol ether 1-50%, the agent can improve absorption of collagen.
Description
Technical field
The present invention relates to a kind of health food, particularly relate to a kind of anti-aging colon absorption preparation.
Background technology
Along with improving constantly of people's living standard, people more and more pay attention to the health of self, and wish to improve immunity, delaying senility by taking health food.
At present, it is found that some native compound can make organism produce biochemical reactions, to the recovery generation active influence of function of human body.
Collagen protein is a kind of glycoprotein, and molecule contains sugar and a large amount of glycine, proline and hydroxyproline.Formation to animal and human's body skin, blood vessel, skeleton, muscle tendon, tooth and cartilage is all very important, is the main matrix of forming these connective tissues.If the biosynthesis abnormality of collagen protein, or collagen protein causes ANOMALOUS VARIATIONS because of other reasons, just might cause collagen.Clinically, rheumatic and rheumatoid arthritis, hyperostosis dirt, osteoporosis etc. all belong to collagen.Such as the bone matrix hyperplasia that day by day increases, it has badly influenced people's work, study and daily life, so it has become the pertinacious disease that world health circle is generally acknowledged now.According to statistics, the people more than 40 years old has 45-50% hyperosteogeny to occur; After 60 years old, the people more than 80% more or less hyperosteogeny can occur.
Collagen protein can promote the formation of bone, strengthens the ossein structure under the low calcium level, thereby improves bone strength, reaches the effect of prevention of osteoporosis hypertrophy disease; Collagen protein can be used as the metabolism agent and uses for normal population, promotes that organism hose lining protozoa is synthetic, improves the biological tissue's aging and the hypofunction that cause because of age growth.Being that everybody is usually said has beauty treatment, skin moistening, an antidotal effect.Collagen protein also has other many special physiological functions in addition, and as protection gastric mucosa and antiulcer action, anti-allergic effects suppresses the effect of hypertension, and some special acids in the collagen protein also have protective effect on cancer risk.And collagen protein itself is a protein substance, and is without any side effects, can eat for a long time.
Semen Vitis viniferae extract is one of antioxidant the most efficiently that derives from plant of finding so far, its antioxidant effect, be vitamin C and vitamin E 30-50 doubly, have the powerful effect of removing free radical, improving body immunity.
Chitosan has the immunity of raising, suppresses the cancerous protuberance cell and grows up, and promotes liver spleen antibody to form, and promotes the absorption of calcium and mineral, blood fat reducing, blood pressure lowering, blood sugar lowering, cholesterol regulating, fat-reducing, functions such as prevention adult disease.Oligo-chitosan also has obvious elimination human body negative oxygen ion free radical, and slow down aging suppresses the harmful bacterium of skin surface and grows, excellent properties such as preserve moisture.
Present antidotal preparation mainly is the preparation through stomach and little intestinal absorption, and there is first pass effect in medicine protein ingredient in the one side medicine through gastrointestinal tract the time on the other hand by protease digestion, and bioavailability is reduced.
Collagen protein polypeptide can not be through gastrointestinal absorption, and reason mainly is: 1, polypeptide molecular weight is big, and is fat-soluble poor, is difficult to by the biomembrane barrier; 2, exist a large amount of peptidohydrolases and proteolytic enzyme in the gastrointestinal tract, the degradable polypeptide; 3, easily eliminated (first pass effect) after the absorption by liver.
Summary of the invention
The purpose of this invention is to provide a kind of anti-aging colon absorption preparation, the present invention is for improving the absorbance of polypeptide, it is organically combined native compounds such as collagen protein, Semen Vitis viniferae extract, chitosan and makes the dissolved preparation of rectum, the first pass effect that it can significantly reduce the gastrointestinal absorbable preparation is big, the deficiency that albumen easily is hydrolyzed, to improve beauty treatment, skin care, the effect that improves immunity.
Technical scheme of the present invention is summarized as follows:
A kind of anti-aging colon absorption preparation is made up of following component: collagen protein powder 30-80% by weight percentage; Semen Vitis viniferae extract 1-10%; Vitamin C 1-20%; Vitamin E 0-20%; Calcium carbonate or calcium acetate or calcium gluconate or sclerotin calcium phosphate or calcium amino acid chelate or calcium lactate or calcium citrate 0-50%; The dirt thing 9-15% that spreads out of chitosan or chitosan salt or chitosan; Microcrystalline Cellulose or carboxymethyl starch sodium or low-substituted hydroxypropyl cellulose 1-50% pack said components in the colon dissolving capsule into, make a kind of anti-aging colon absorption preparation.
Described collagen protein powder is preferably 40-60%; Described Semen Vitis viniferae extract is preferably 2-5%; Described vitamin C is preferably 5-10%; Described vitamin E is preferably 5-10%; Described calcium carbonate or calcium acetate or calcium gluconate or sclerotin calcium phosphate or calcium amino acid chelate or calcium lactate or calcium citrate are preferably 10-40%; The derivant of described chitosan or chitosan salt or chitosan is preferably 10%.
Described chitosan salt can select chitosan succinate or chitosan phthalate or chitosan glutamate salt or chitosan aspartate or chitosan lysinate.
The derivant of described chitosan can be selected N-(2-carboxyl)-propyl group-3-trimethyl ammonium Sea Cure CL 313.
A kind of anti-aging colon absorption preparation is made up of following component: collagen protein powder 30-80% by weight percentage; Semen Vitis viniferae extract 1-10%; Vitamin C 1-20%; Vitamin E 0-20%; Calcium carbonate or calcium acetate or calcium gluconate or sclerotin calcium phosphate or calcium amino acid chelate or calcium lactate or calcium citrate 0-50%; The dirt thing 9-15% that spreads out of chitosan or chitosan salt or chitosan; Microcrystalline Cellulose or carboxymethyl starch sodium or low-substituted hydroxypropyl cellulose 1-50%, said components is added binding agent make soft material, described binding agent is weight percentage and is the alcoholic solution of the Polyethylene Glycol of 50-100%, described binding agent addition is the 10-30% of described each component weight sum, the granulation of sieving, in coating pan, be rolled onto bead, enteric coated after drying; In the colon of packing into the dissolving capsule, make a kind of anti-aging colon absorption preparation.
Described chitosan salt can select chitosan succinate or chitosan phthalate or chitosan glutamate salt or chitosan aspartate or chitosan lysinate.
The derivant of described chitosan can be selected N-(2-carboxyl)-propyl group-3-trimethyl ammonium Sea Cure CL 313.
A kind of anti-aging colon absorption preparation is made up of following component: collagen protein powder 30-80% by weight percentage; Semen Vitis viniferae extract 1-10%; Vitamin C 1-20%; Vitamin E 0-20%; Calcium carbonate or calcium acetate or calcium gluconate or sclerotin calcium phosphate or calcium amino acid chelate or calcium lactate or calcium citrate 0-50%; The derivant 9-15% of chitosan or chitosan salt or chitosan; Microcrystalline Cellulose or carboxymethyl starch sodium or low-substituted hydroxypropyl cellulose 1-50%, with described microcrystalline Cellulose or carboxymethyl starch sodium or low-substituted hydroxypropyl cellulose is celphere, add described collagen protein powder, Semen Vitis viniferae extract, vitamin C, vitamin E, calcium compounds, the derivant of chitosan or chitosan salt or chitosan and binding agent, described binding agent is a water, the addition of described binding agent is the 10-30% of each component weight sum, be rolled onto micropill, inclusion enteric coating again, dry, in the colon of packing into the dissolving capsule, make a kind of anti-aging colon absorption preparation.
Described chitosan salt can select chitosan succinate or chitosan phthalate or chitosan glutamate salt or chitosan aspartate or chitosan lysinate.
The derivant of described chitosan is N-(2-carboxyl)-propyl group-3-trimethyl ammonium Sea Cure CL 313.
A kind of anti-aging colon absorption preparation is made up of following component: collagen protein powder 30-80% by weight percentage; Semen Vitis viniferae extract 1-10%; Vitamin C 1-20%; Vitamin E 0-20%; Calcium compounds 0-50%; The derivant 9-15% of chitosan or chitosan salt or chitosan; Microcrystalline Cellulose or carboxymethyl starch sodium or low-substituted hydroxypropyl cellulose 1-50%, take by weighing all materials by recipe quantity, with volume ratio is 1: 1-1: 2 poly-second two outer coffins and ethanol water are granulated, the concentration of volume percent of described ethanol water is a 90%-100% ethanol, 30-50 ℃ of drying, granulate, tabletting, with its S100 of You Te or polyacrylic resin bag casing, enteric layers thickness is 0.01mm～10.0mm, 30-50 ℃ of drying.
Described chitosan salt can select the salt of chitosan succinic acid or chitosan phthalic acid or chitosan glutamate or chitosan aspartic acid or chitosan lysine.
The derivant of described chitosan is N-(2-carboxyl)-propyl group-3-trimethyl ammonium Sea Cure CL 313.
The present invention adopts advanced colon administration system, owing to used chitosan among the present invention, and chitosan easily adheres to colon surface, has improved the biomembrane permeability of polypeptide.The present invention can improve the biomembrane permeability of collagen protein polypeptide and can reduce albumen by its corresponding enzymatic degradation, and improves absorbance.The absorption of collagen protein can produce more positive beauty treatment and health-care effect to human body.In addition, food of the present invention is easy to carry, and is easy to use, is young girl's good health food.Also the numerous disease patient is had good health-care effect, its anti-aging effects also makes it to become the first-selection of vast middle aged and aged women health care.
The specific embodiment
The present invention is further illustrated below in conjunction with specific embodiment:
Embodiment 1
A kind of anti-aging colon absorption preparation is made up of following component: collagen protein powder 50% by weight percentage; Semen Vitis viniferae extract 5%; Vitamin C 7%; Vitamin E 8%; Calcium carbonate 12%; Chitosan 9%; Microcrystalline Cellulose 9% is packed said components in the colon dissolving capsule into, makes a kind of anti-aging colon absorption preparation.
Embodiment 2
A kind of anti-aging colon absorption preparation is made up of following component: collagen protein powder 40% by weight percentage; Semen Vitis viniferae extract 4%; Vitamin C 1%; Vitamin E2 0%; Calcium acetate 10%; Chitosan succinate 15%; Carboxymethyl starch sodium 10% is packed said components in the colon dissolving capsule into, makes a kind of anti-aging colon absorption preparation.
Embodiment 3
A kind of anti-aging colon absorption preparation is made up of following component: collagen protein powder 60% by weight percentage; Semen Vitis viniferae extract 10%; Vitamin C 5%; Vitamin E 5%; Chitosan phthalate 10%; Low-substituted hydroxypropyl cellulose 10% is packed said components in the colon dissolving capsule into, makes a kind of anti-aging colon absorption preparation.
Embodiment 4
A kind of anti-aging colon absorption preparation is made up of following component: collagen protein powder 30% by weight percentage; Semen Vitis viniferae extract 1%; Vitamin C 1%; Calcium gluconate 50%; Chitosan glutamate salt 9%; Microcrystalline Cellulose 9% is packed said components in the colon dissolving capsule into, makes a kind of anti-aging colon absorption preparation.
Embodiment 5
A kind of anti-aging colon absorption preparation is made up of following component: collagen protein powder 80% by weight percentage; Semen Vitis viniferae extract 1%; Vitamin C 1%; Chitosan aspartate 9%; Microcrystalline Cellulose 9% is packed said components in the colon dissolving capsule into, makes a kind of anti-aging colon absorption preparation.
Embodiment 6
A kind of anti-aging colon absorption preparation is made up of following component: collagen protein powder 40% by weight percentage; Semen Vitis viniferae extract 2%; Catergen 0%; Vitamin E 8%; Sclerotin calcium phosphate 10%; Chitosan lysinate 10%; Microcrystalline Cellulose 10% is packed said components in the colon dissolving capsule into, makes a kind of anti-aging colon absorption preparation.
Embodiment 7
A kind of anti-aging colon absorption preparation is made up of following component: collagen protein powder 30% by weight percentage; Semen Vitis viniferae extract 1%; Vitamin C 10%; Calcium amino acid chelate 40%; N-(2-carboxyl)-propyl group-3-trimethyl ammonium Sea Cure CL 313 10%; Microcrystalline Cellulose 9% is packed said components in the colon dissolving capsule into, makes a kind of anti-aging colon absorption preparation.
Embodiment 8
A kind of anti-aging colon absorption preparation is made up of following component: collagen protein powder 50% by weight percentage; Semen Vitis viniferae extract 5%; Vitamin C 13%; Vitamin e1 0%; Calcium lactate 12%; N-(2-carboxyl)-propyl group-3-trimethyl ammonium Sea Cure CL 313 9%; Microcrystalline Cellulose 1% is packed said components in the colon dissolving capsule into, makes a kind of anti-aging colon absorption preparation.
Embodiment 9
A kind of anti-aging colon absorption preparation is made up of following component: collagen protein powder 30% by weight percentage; Semen Vitis viniferae extract 1%; Vitamin C 1%; Vitamin E 8%; Calcium citrate 1%; Chitosan 9%; Microcrystalline Cellulose 50% is packed said components in the colon dissolving capsule into, makes a kind of anti-aging colon absorption preparation.
Embodiment 10
A kind of anti-aging colon absorption preparation is made up of following component: collagen protein powder 50% by weight percentage; Semen Vitis viniferae extract 5%; Vitamin C 7%; Vitamin E 8%; Calcium carbonate 12%; Chitosan 9%; Microcrystalline Cellulose 9%, said components is added the alcoholic solution that percentage by weight is 50% Polyethylene Glycol, and the alcoholic solution addition of Polyethylene Glycol is 30% of a described each component weight sum, the granulation of sieving, in coating pan, be rolled onto bead, enteric coated after drying; In the colon of packing into the dissolving capsule, make a kind of anti-aging colon absorption preparation.
Embodiment 11
A kind of anti-aging colon absorption preparation is made up of following component: collagen protein powder 40% by weight percentage; Semen Vitis viniferae extract 4%; Vitamin C 1%; Vitamin E2 0%; Calcium acetate 10%; Chitosan succinate 15%; Carboxymethyl starch sodium 10% adds Polyethylene Glycol with said components, and the Polyethylene Glycol addition is 20% of a described each component weight sum, and the granulation of sieving is rolled onto bead in coating pan, enteric coated after drying; In the colon of packing into the dissolving capsule, make a kind of anti-aging colon absorption preparation.
Embodiment 12
A kind of anti-aging colon absorption preparation is made up of following component: collagen protein powder 60% by weight percentage; Semen Vitis viniferae extract 10%; Vitamin C 5%; Vitamin E 5%; Chitosan phthalate 10%; Microcrystalline Cellulose 10%, said components is added the alcoholic solution that percentage by weight is 60% Polyethylene Glycol, and the alcoholic solution addition of Polyethylene Glycol is 10% of a described each component weight sum, the granulation of sieving, in coating pan, be rolled onto bead, enteric coated after drying; In the colon of packing into the dissolving capsule, make a kind of anti-aging colon absorption preparation.
Embodiment 12
A kind of anti-aging colon absorption preparation is made up of following component: collagen protein powder 60% by weight percentage; Semen Vitis viniferae extract 10%; Vitamin C 5%; Vitamin E 5%; Chitosan phthalate 10%; Low-substituted hydroxypropyl cellulose 10%, said components is added the alcoholic solution that percentage by weight is 70% Polyethylene Glycol, and the alcoholic solution addition of Polyethylene Glycol is 20% of a described each component weight sum, the granulation of sieving, in coating pan, be rolled onto bead, enteric coated after drying; In the colon of packing into the dissolving capsule, make a kind of anti-aging colon absorption preparation.
Embodiment 13
A kind of anti-aging colon absorption preparation is made up of following component: collagen protein powder 30% by weight percentage; Semen Vitis viniferae extract 1%; Vitamin C 1%; Calcium gluconate 50%; Chitosan glutamate salt 9%; Microcrystalline Cellulose 9%, said components is added the alcoholic solution that percentage by weight is 80% Polyethylene Glycol, and the alcoholic solution addition of Polyethylene Glycol is 20% of a described each component weight sum, the granulation of sieving, in coating pan, be rolled onto bead, enteric coated after drying; In the colon of packing into the dissolving capsule, make a kind of anti-aging colon absorption preparation.
Embodiment 14
A kind of anti-aging colon absorption preparation is made up of following component: collagen protein powder 80% by weight percentage; Semen Vitis viniferae extract 1%; Vitamin C 1%; Chitosan aspartate 9%; Microcrystalline Cellulose 9%, said components is added the alcoholic solution that percentage by weight is 75% Polyethylene Glycol, and the alcoholic solution addition of Polyethylene Glycol is 10% of a described each component weight sum, the granulation of sieving, in coating pan, be rolled onto bead, enteric coated after drying; In the colon of packing into the dissolving capsule, make a kind of anti-aging colon absorption preparation.
Embodiment 15
A kind of anti-aging colon absorption preparation is made up of following component: collagen protein powder 40% by weight percentage; Semen Vitis viniferae extract 2%; Catergen 0%; Vitamin E 8%; Sclerotin calcium phosphate 10%; Chitosan lysinate 10%; Microcrystalline Cellulose 10%, said components is added the alcoholic solution that percentage by weight is 85% Polyethylene Glycol, and the alcoholic solution addition of Polyethylene Glycol is 30% of a described each component weight sum, the granulation of sieving, in coating pan, be rolled onto bead, enteric coated after drying; In the colon of packing into the dissolving capsule, make a kind of anti-aging colon absorption preparation.
Embodiment 16
A kind of anti-aging colon absorption preparation is made up of following component: collagen protein powder 30% by weight percentage; Semen Vitis viniferae extract 1%; Vitamin C 10%; Calcium amino acid chelate 40%; N-(2-carboxyl)-propyl group-3-trimethyl ammonium Sea Cure CL 313 10%; Microcrystalline Cellulose 9%, said components is added the alcoholic solution that percentage by weight is 90% Polyethylene Glycol, and the alcoholic solution addition of Polyethylene Glycol is 20% of a described each component weight sum, the granulation of sieving, in coating pan, be rolled onto bead, enteric coated after drying; In the colon of packing into the dissolving capsule, make a kind of anti-aging colon absorption preparation.
Embodiment 17
A kind of anti-aging colon absorption preparation is made up of following component: collagen protein powder 50% by weight percentage; Semen Vitis viniferae extract 5%; Vitamin C 13%; Vitamin e1 0%; Calcium lactate 12%; N-(2-carboxyl)-propyl group-3-trimethyl ammonium Sea Cure CL 313 9%; Microcrystalline Cellulose 1%, said components is added the alcoholic solution that percentage by weight is 90% Polyethylene Glycol, and the alcoholic solution addition of Polyethylene Glycol is 20% of a described each component weight sum, the granulation of sieving, in coating pan, be rolled onto bead, enteric coated after drying; In the colon of packing into the dissolving capsule, make a kind of anti-aging colon absorption preparation.
Embodiment 18
A kind of anti-aging colon absorption preparation is made up of following component: collagen protein powder 30% by weight percentage; Semen Vitis viniferae extract 1%; Vitamin C 1%; Vitamin E 8%; Calcium citrate 1%; Chitosan 9%; Microcrystalline Cellulose 50%, said components is added the alcoholic solution that percentage by weight is 80% Polyethylene Glycol, and the alcoholic solution addition of Polyethylene Glycol is 20% of a described each component weight sum, the granulation of sieving, in coating pan, be rolled onto bead, enteric coated after drying; In the colon of packing into the dissolving capsule, make a kind of anti-aging colon absorption preparation.
Embodiment 19
A kind of anti-aging colon absorption preparation is made up of following component: collagen protein powder 50% by weight percentage; Semen Vitis viniferae extract 5%; Vitamin C 7%; Vitamin E 8%; Calcium carbonate 12%; Chitosan 9%; Microcrystalline Cellulose 9%, with described microcrystalline Cellulose is celphere, add described collagen protein powder, Semen Vitis viniferae extract, vitamin C, vitamin E, calcium carbonate, chitosan and water, the addition of water is 10% of an each component weight sum, be rolled onto micropill, inclusion enteric coating again, drying, in the colon of packing into the dissolving capsule, make a kind of anti-aging colon absorption preparation.
Embodiment 20
A kind of anti-aging colon absorption preparation is made up of following component: collagen protein powder 40% by weight percentage; Semen Vitis viniferae extract 4%; Vitamin C 1%; Vitamin E2 0%; Calcium acetate 10%; Chitosan succinate 15%; Carboxymethyl starch sodium 10%, with carboxymethyl starch sodium is celphere, add described collagen protein powder, Semen Vitis viniferae extract, vitamin C, vitamin E, calcium acetate, chitosan succinate and water, the addition of described water is 20% of an each component weight sum, be rolled onto micropill, inclusion enteric coating again, drying, in the colon of packing into the dissolving capsule, make a kind of anti-aging colon absorption preparation.
Embodiment 21
A kind of anti-aging colon absorption preparation is made up of following component: collagen protein powder 60% by weight percentage; Semen Vitis viniferae extract 10%; Vitamin C 5%; Vitamin E 5%; Chitosan phthalate 10%; Low-substituted hydroxypropyl cellulose 10%, with described low-substituted hydroxypropyl cellulose is celphere, add described collagen protein powder, Semen Vitis viniferae extract, vitamin C, vitamin E, chitosan phthalate and water, the addition of described water is 30% of an each component weight sum, be rolled onto micropill, inclusion enteric coating again, drying, in the colon of packing into the dissolving capsule, make a kind of anti-aging colon absorption preparation.
Embodiment 22
A kind of anti-aging colon absorption preparation is made up of following component: collagen protein powder 30% by weight percentage; Semen Vitis viniferae extract 1%; Vitamin C 1%; Calcium gluconate 50%; Chitosan glutamate salt 9%; Microcrystalline Cellulose 9%, with described microcrystalline Cellulose is celphere, add described collagen protein powder, Semen Vitis viniferae extract, vitamin C, calcium gluconate, chitosan glutamate salt and water, the addition of described water is 20% of an each component weight sum, be rolled onto micropill, inclusion enteric coating again, drying, in the colon of packing into the dissolving capsule, make a kind of anti-aging colon absorption preparation.
Embodiment 23
A kind of anti-aging colon absorption preparation is made up of following component: collagen protein powder 80% by weight percentage; Semen Vitis viniferae extract 1%; Vitamin C 1%; Chitosan aspartate 9%; Microcrystalline Cellulose 9%, with described microcrystalline Cellulose is celphere, add described collagen protein powder, Semen Vitis viniferae extract, vitamin C, chitosan aspartate and water, the addition of described water is 20% of an each component weight sum, be rolled onto micropill, inclusion enteric coating again, drying, in the colon of packing into the dissolving capsule, make a kind of anti-aging colon absorption preparation.
Embodiment 24
A kind of anti-aging colon absorption preparation is made up of following component: collagen protein powder 40% by weight percentage; Semen Vitis viniferae extract 2%; Catergen 0%; Vitamin E 8%; Sclerotin calcium phosphate 10%; Chitosan lysinate 10%; Microcrystalline Cellulose 10%, with described microcrystalline Cellulose is celphere, add described collagen protein powder, Semen Vitis viniferae extract, vitamin C, vitamin E, sclerotin calcium phosphate, chitosan lysinate and water, the addition of described water is 20% of an each component weight sum, be rolled onto micropill, inclusion enteric coating again, drying, in the colon of packing into the dissolving capsule, make a kind of anti-aging colon absorption preparation.
Embodiment 25
A kind of anti-aging colon absorption preparation is made up of following component: collagen protein powder 30% by weight percentage; Semen Vitis viniferae extract 1%; Vitamin C 10%; Calcium amino acid chelate 40%; N-(2-carboxyl)-propyl group-3-trimethyl ammonium Sea Cure CL 313 10%; Microcrystalline Cellulose 9%, with described microcrystalline Cellulose is celphere, add described collagen protein powder, Semen Vitis viniferae extract, vitamin C, calcium amino acid chelate, N-(2-carboxyl)-propyl group-3-trimethyl ammonium Sea Cure CL 313 and water, the addition of described water is 10% of an each component weight sum, be rolled onto micropill, inclusion enteric coating again, drying, in the colon of packing into the dissolving capsule, make a kind of anti-aging colon absorption preparation.
Embodiment 26
A kind of anti-aging colon absorption preparation is made up of following component: collagen protein powder 50% by weight percentage; Semen Vitis viniferae extract 5%; Vitamin C 13%; Vitamin e1 0%; Calcium lactate 12%; N-(2-carboxyl)-propyl group-3-trimethyl ammonium Sea Cure CL 313 9%; Microcrystalline Cellulose 1%, with described microcrystalline Cellulose is celphere, add described collagen protein powder, Semen Vitis viniferae extract, vitamin C, vitamin E, calcium lactate, N-(2-carboxyl)-propyl group-3-trimethyl ammonium Sea Cure CL 313 and water, the addition of described water is 20% of an each component weight sum, be rolled onto micropill, inclusion enteric coating again, drying, in the colon of packing into the dissolving capsule, make a kind of anti-aging colon absorption preparation.
Embodiment 27
A kind of anti-aging colon absorption preparation is made up of following component: collagen protein powder 30% by weight percentage; Semen Vitis viniferae extract 1%; Vitamin C 1%; Vitamin E 8%; Calcium citrate 1%; Chitosan 9%; Microcrystalline Cellulose 50%, with described microcrystalline Cellulose is celphere, add described collagen protein powder, Semen Vitis viniferae extract, vitamin C, vitamin E, calcium citrate, chitosan and water, the addition of described water is 20% of an each component weight sum, be rolled onto micropill, inclusion enteric coating again, drying, in the colon of packing into the dissolving capsule, make a kind of anti-aging colon absorption preparation.
Embodiment 28
A kind of anti-aging colon absorption preparation is made up of following component: collagen protein powder 50% by weight percentage; Semen Vitis viniferae extract 5%; Vitamin C 7%; Vitamin E 8%; Calcium carbonate 12%; Chitosan 9%; Microcrystalline Cellulose 9%, take by weighing all materials by recipe quantity, with volume ratio is that 1: 1 poly-second two outer coffins and ethanol water are granulated, the concentration of volume percent of described ethanol water is 90% ethanol, 30 ℃ of dryings, granulate, tabletting, with its S100 bag casing of You Te, enteric layers thickness is 0.01mm, 30 ℃ of dryings.
Embodiment 29
A kind of anti-aging colon absorption preparation is made up of following component: collagen protein powder 40% by weight percentage; Semen Vitis viniferae extract 4%; Vitamin C 1%; Vitamin E2 0%; Calcium acetate 10%; Chitosan succinate 15%; Carboxymethyl starch sodium 10%, take by weighing all materials by recipe quantity, with volume ratio is that 1: 2 poly-second two outer coffins and ethanol water are granulated, described ethanol concentration of volume percent is 100% ethanol, 40 ℃ of dryings, granulate, tabletting, with polyacrylic resin bag casing, enteric layers thickness is 10.0mm, 40 ℃ of dryings.
Embodiment 30
A kind of anti-aging colon absorption preparation is made up of following component: collagen protein powder 60% by weight percentage; Semen Vitis viniferae extract 10%; Vitamin C 5%; Vitamin E 5%; Chitosan phthalate 10%; Low-substituted hydroxypropyl cellulose 10%, take by weighing all materials by recipe quantity, with volume ratio is that 1: 1 poly-second two outer coffins and ethanol water are granulated, the concentration of volume percent of described ethanol water is 95% ethanol, 50 ℃ of dryings, granulate, tabletting, with polyacrylic resin bag casing, enteric layers thickness is 5.0mm, 50 ℃ of dryings.
A kind of anti-aging colon absorption preparation survey report-disintegration
Stripping and the release of a kind of anti-aging colon absorption preparation of embodiment 1 in simulated gastric fluid or intestinal juice
| The position | The Ph value | Dissolution time | Discharge |
| Simulated gastric fluid | 2.8 | 2h | 0 |
| Simulated intestinal fluid | 6.8 | 1h | 0 |
| Distal small intestine | 7.0 | 34min | 100％ |
Chitosan among the present invention itself can help collagen protein to be adsorbed onto on the colon wall again both as dietary fiber, promotes the absorption of collagen protein polypeptide, and the best position of protein adsorption is exactly a colon.And chitosan is the carrier of conlon targeting system.The flora that caecum, colonic exist has produced the enzyme of degrade chitosan, so chitosan as the carrier of collagen protein polypeptide, can well be delivered to colon to it, promotes its absorption.
The present invention is easy to use, and have no side effect, the present invention is trying out through continuous or interruption in the time more than 3 years, after to the optimization of formulation combination, to 78 examples (male 32 examples, woman's 46 examples) trier carries out the follow-up investigation observation, took for three weeks, every day three times, each 2, confirm through the immune function of human body test, take a kind of anti-aging colon absorption preparation of the present invention and can obviously strengthen the middle-aged and elderly people immunologic function, T lymphocyte conversion ratio improves 98%, can reduce lipid peroxide (LPO) level that causes people's aging in the body, and the male descends 35%, the women descends 70%, and glutathion peroxidase (GPX) activity that has anti-aging effects in the body is obviously improved, and the male improves 33%, and the women improves 30%, 78 routine triers are carried out questionnaire survey to be shown, 65% male and women's appetite of 45% strengthen to some extent, all surveyees, and none reflects appetite, it is preceding poor that sleep and energy are taken.
Claims (10)
1. an anti-aging colon absorption preparation is characterized in that being made up of following component by weight percentage: collagen protein powder 30-80%; Semen Vitis viniferae extract 1-10%; Vitamin C 1-20%; Vitamin E 0-20%; Calcium carbonate or calcium acetate or calcium gluconate or sclerotin calcium phosphate or calcium amino acid chelate or calcium lactate or calcium citrate 0-50%; The derivant 9-15% of chitosan or chitosan salt or chitosan; Microcrystalline Cellulose or carboxymethyl starch sodium or low-substituted hydroxypropyl cellulose 1-50% pack said components in the colon dissolving capsule into, make a kind of anti-aging colon absorption preparation.
2. a kind of anti-aging colon absorption preparation according to claim 1 is characterized in that described collagen protein powder is 40-60%; Described Semen Vitis viniferae extract is 2-5%; Described vitamin C is 5-10%; Described vitamin E is 5-10%; Described calcium carbonate or calcium acetate or calcium gluconate or sclerotin calcium phosphate or calcium amino acid chelate or calcium lactate or calcium citrate are 10-40%; The derivant of described chitosan or chitosan salt or chitosan is 10%.
3. a kind of anti-aging colon absorption preparation according to claim 1 and 2 is characterized in that described chitosan salt is chitosan succinate or chitosan phthalate or chitosan glutamate salt or chitosan aspartate or chitosan lysinate.
4. a kind of anti-aging colon absorption preparation according to claim 1 and 2, the derivant that it is characterized in that described chitosan are N-(2-carboxyl)-propyl group-3-trimethyl ammonium Sea Cure CL 313.
5. an anti-aging colon absorption preparation is characterized in that being made up of following component by weight percentage: collagen protein powder 30-80%; Semen Vitis viniferae extract 1-10%; Vitamin C 1-20%; Vitamin E 0-20%; Calcium carbonate or calcium acetate or calcium gluconate or sclerotin calcium phosphate or calcium amino acid chelate or calcium lactate or calcium citrate 0-50%; The derivant 9-15% of chitosan or chitosan salt or chitosan; Microcrystalline Cellulose or carboxymethyl starch sodium or low-substituted hydroxypropyl cellulose 1-50%, said components is added binding agent make soft material, described binding agent is weight percentage and is the alcoholic solution of the Polyethylene Glycol of 50-100%, described binding agent addition is the 10-30% of described each component weight sum, the granulation of sieving, in coating pan, be rolled onto bead, enteric coated after drying; In the colon of packing into the dissolving capsule, make a kind of anti-aging colon absorption preparation.
6. a kind of anti-aging colon absorption preparation according to claim 5 is characterized in that described chitosan salt is chitosan succinate or chitosan phthalate or chitosan glutamate salt or chitosan aspartate or chitosan lysinate.
7. a kind of anti-aging colon absorption preparation according to claim 5, the derivant that it is characterized in that described chitosan are N-(2-carboxyl)-propyl group-3-trimethyl ammonium Sea Cure CL 313.
8. an anti-aging colon absorption preparation is characterized in that being made up of following component by weight percentage: collagen protein powder 30-80%; Semen Vitis viniferae extract 1-10%; Vitamin C 1-20%; Vitamin E 0-20%; Calcium carbonate or calcium acetate or calcium gluconate or sclerotin calcium phosphate or calcium amino acid chelate or calcium lactate or calcium citrate 0-50%; The derivant 9-15% of chitosan or chitosan salt or chitosan; Microcrystalline Cellulose or carboxymethyl starch sodium or low-substituted hydroxypropyl cellulose 1-50%, with described microcrystalline Cellulose or carboxymethyl starch sodium or low-substituted hydroxypropyl cellulose is celphere, add described collagen protein powder, Semen Vitis viniferae extract, vitamin C, vitamin E, calcium compounds, the derivant of chitosan or chitosan salt or chitosan and binding agent, described binding agent is a water, the addition of described binding agent is the 10-30% of each component weight sum, be rolled onto micropill, inclusion enteric coating again, dry, in the colon of packing into the dissolving capsule, make a kind of anti-aging colon absorption preparation.
9. a kind of anti-aging colon absorption preparation according to claim 8 is characterized in that described chitosan salt is chitosan succinate or chitosan phthalate or chitosan glutamate salt or chitosan aspartate or chitosan lysinate.
10. a kind of anti-aging colon absorption preparation according to claim 8, the derivant that it is characterized in that described chitosan are N-(2-carboxyl)-propyl group-3-trimethyl ammonium Sea Cure CL 313.
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