CN1953219A - Light source generator for medical equipment - Google Patents

Abstract

The invention provides a light source generator of medical equipment, which mainly uses a high-power light-emitting diode as a light source for photodynamic diagnosis and treatment to provide light with high brightness and proper wavelength (such as 300-900 nm), and diagnoses an affected part or treats the affected part by matching with the reaction of light sensitive medicines, and the heat energy generated by the high-power light-emitting diode during the light emitting process can also obtain excellent heat dissipation effect by the action of a heat dissipation device (such as a heat dissipation fin, a fan, a thermoelectric cooler or a heat conduction pipe) configured by the invention.

Description

Light source generator for medical equipment

technical field

The present invention relates to a light source generator, and in particular to a high-power light emitting diode (Light Emitting Diode; LED) and its application in photodynamic diagnosis (PDD: photodynamic diagnosis) or photodynamic therapy (Photodynamic Therapy; PDT) Light source generator for medical equipment.

Background technique

Photodynamic therapy (PDT), also known as photoradiation therapy (PRT, photoradiation therapy), can selectively cause abnormal cell necrosis without harming surrounding normal tissues. It is a new cancer treatment technology that combines light sources and special light-sensitive drugs. .

The basis of photodynamic therapy is the photodynamic effect. This is a photosensitization reaction accompanied by biological effects involving oxygen molecules. The process is to excite the photosensitizer absorbed by specific cell tissue by irradiation with light of a specific wavelength, and the photosensitizer in the excited state transfers energy to the surrounding oxygen to generate highly active singlet oxygen, singlet oxygen and phase Adjacent biomacromolecules undergo oxidation reactions, resulting in cytotoxicity, which in turn leads to cell damage and even death.

At present, laser is the most common light source used in photodynamic therapy, but the cost of using laser and expensive maintenance make the price of photodynamic diagnosis and treatment remain high.

In order to overcome the defects produced by the laser light source, the prior art also proposes to use a light emitting diode array (LED array) as a light source for diagnosis and treatment. For related technologies, please refer to U.S. Patent No. 5,698,866 and No. 6,402,347. For the high heat generated when it emits light, the existing technology uses a water-cooled circulation heat sink to achieve heat exchange. For related technologies, please refer to US Patent Nos. 5,698,866 and 5,728,090. However, using light-emitting diode arrays as the light source for diagnosis and treatment can reduce the price of light diagnosis and treatment, but the volume of the light source is limited, so that the light source cannot be directly used for diagnosis and treatment when the light-emitting diode array is used to treat the affected parts of the cavity such as the oral cavity, so it is only suitable for Superficial treatment and diagnosis.

In addition, regardless of the above-mentioned laser or light-emitting diode array as the light source for diagnosis and treatment, one or more optical lenses will be installed at the front of the light source, such as: collimator lens, focusing lens, etc. The related technologies can be See US Patent Nos. 5,568,503, 6,402,347, 6,513,962, and 6,832,849. However, installing these optical lenses requires high assembly precision, which makes the assembly of this type of light source generator more complicated and difficult.

Contents of the invention

Therefore, the object of the present invention is to provide a light source generator for medical equipment, which can provide light with high brightness and appropriate wavelength, which can be used in conjunction with photosensitive drugs to diagnose or treat affected parts, and has a good heat dissipation effect.

Based on the above purpose, the present invention provides a light source generator for medical equipment, which is mainly composed of a high-power light-emitting diode and a heat dissipation device. Among them, the high-power light-emitting diode is suitable for emitting high-brightness light of a specific wavelength for diagnosing or treating the affected part. . Since the light source of the light source generator of the present invention uses high-power light-emitting diodes to replace laser diodes or light-emitting diode arrays in the prior art, it can provide high-brightness and light of appropriate wavelengths to diagnose the affected part or treat the affected part. In addition, high-power The thermal energy generated when the light-emitting diode emits light can obtain an excellent heat dissipation effect through the action of the heat dissipation device.

The light source generator for medical equipment according to the present invention has at least the following advantages:

1. The light source according to the present invention adopts high-power light-emitting diodes, which can solve the problem that the light-emitting diode array used as the light source in the prior art is limited to too large a volume and can only be applied to surface treatment and diagnosis. The light source has great advantages in terms of price and subsequent maintenance costs.

2. According to the high-power light-emitting diode of the present invention, the accompanying high heat generated when emitting light can be guided by the heat dissipation device to obtain an excellent heat dissipation effect.

3. The light guide cylinder according to the present invention can guide the light emitted by the high-power light-emitting diode to the lumen of the human body, thereby increasing the range of illumination. In addition, high-power light-emitting diodes are used as the light source, and the front end of the light source does not need to install a lens as in the prior art, and can be directly coupled with the light guide column, so that the assembly is easier, and because the light source does not use lasers, the light guide column Body (such as optical fiber) has low accuracy requirements when coupling and aligning with the light source, so the angle deviation between the light and the optical axis of the optical fiber does not need to be limited within a narrow range, and it is easier to meet the accuracy requirements of assembly and component dimensions .

4. The light source generator according to the present invention can be applied to photodynamic therapy (PDT) and photodynamic diagnosis such as cancer and non-cancer related photodynamic diagnosis and treatment of rheumatoid arthritis, arterial tissue treatment, microbial diagnosis and sterilization (PDD) field, its practicality is very high.

Description of drawings

FIG. 1 is a schematic diagram of a preferred embodiment of a light source generator of a medical device according to the present invention.

FIG. 2 is a side sectional view of FIG. 1 .

3-7 are schematic diagrams of various embodiments of the heat dissipation device of the light source generator of the medical device according to the present invention.

8-10 are schematic diagrams of various embodiments of the light guide column of the light source generator of the medical device according to the present invention.

Detailed ways

The preferred embodiments and technical contents of the present invention are described as follows in conjunction with the accompanying drawings:

The light source generator for medical equipment according to the present invention is mainly composed of a high-power light-emitting diode and a heat dissipation device, wherein the high-power light-emitting diode is suitable for emitting light of a specific wavelength, and the heat dissipation device is used to emit light from the high-power light-emitting diode The accompanying thermal energy removal will be described in detail below.

First of all, please refer to Fig. 1 and Fig. 2 together. In this embodiment, the light source of the light source generator 100 adopts a high-power light-emitting diode 110. Because it is a high-power type, it can emit high-brightness light. Wavelength (such as 300-900nm) to diagnose or treat the affected part. In more detail, the high-power light-emitting diode 110 according to the present invention can first select light in a wavelength range to irradiate the human body, so as to excite the photosensitive drug applied or injected on the human body, thereby generating detectable fluorescence, and then assisting Define the location of the affected part. After confirming the location of the affected part, you can choose another wavelength range of light to irradiate the affected part. The photochemical reaction will occur between the light and the photosensitive drug on the affected part, and the generation of free radicals in the affected part will cause cell damage. Toxicity, which in turn destroys abnormal cells.

The form of the above-mentioned high-power light-emitting diode 110 is not limited, and it can be a package formed by packaging a single chip or a multi-chip package.

In addition, in this embodiment, the heat dissipation device is, for example, a heat sink 121, which can absorb the heat energy generated when the high-power LED 110 emits light, and perform a heat exchange with the outside air to achieve heat dissipation. Effect. In addition, a power source (not shown) for driving the high-power LED 110 is electrically connected to the high-power LED 110 through the wire 130 . Furthermore, a thermal conductive glue 150 can be coated between the high-power LED 110 and the heat dissipation fins 121 to further enhance the effect of thermal conduction. In addition, the heat dissipation fins 121 may also be integrally formed with the outer shell (not shown) of the light source generator 100 during manufacture, so as to be integrated with the outer shell.

Then, please refer to Fig. 3, in order to increase the effect of heat dissipation, a fan (Fan) 122 can also be configured on the heat dissipation fin 121 in Fig. Thermal energy cools.

However, the heat dissipation device of the present invention is not limited to the above-mentioned types, and various embodiments will be further described below.

Please refer to FIG. 4, in this embodiment, the cooling device is, for example, a thermoelectric cooler (Thermoelectric cooler; TE cooler) 123, and this thermoelectric cooler 123 has a cold end (code side) 123a and a hot end (hot end). side) 123b, and the high-power light-emitting diode is in contact with the cold end 123a. Because a potential difference is applied at both ends of the thermoelectric cooler 123, the electrons are forced to move in the high and low energy levels respectively, resulting in the two ends of the thermoelectric cooler 123 Produce heat absorption and heat release effect, and create a huge temperature difference. Through the above-mentioned functions, the cold end 123a of the thermoelectric cooler 123 can cool down the heat energy generated when the high-power light-emitting diode 110 emits light. Contact to achieve heat exchange.

Next, please refer to FIG. 5 , a cooling fin 124 may be disposed on the hot end 123 b of the thermoelectric cooler 123 in FIG. 4 to increase the contact area with the outside air.

Then, referring to FIG. 6 , a fan (Fan) 125 can also be arranged on the heat dissipation fins 124 in FIG. In addition, a temperature sensor 126 can optionally be arranged on the cooling device, and the temperature sensor 126 is in contact with the thermoelectric cooler 123 to sense the temperature change of the thermoelectric cooler 123 to activate the fan 125 in time.

Furthermore, referring to FIG. 7 , in this embodiment, the heat dissipation device is composed of a heat pipe (Heat Pipe) 127, a heat dissipation fin 128, and a fan 129, for example. One end of the heat pipe 127 is connected to the high-power LED 110 , and the other end is connected to the heat dissipation fin 128 , and the fan 129 is disposed on the heat dissipation fin 128 . Through the liquid-to-gas conversion of the working fluid (not shown) in the heat pipe 127, the heat energy generated when the high-power light-emitting diode 110 emits light is transmitted to the cooling fins 128, and the fan 129 is used to force Cool air is blown to accelerate the cooling of the heat energy absorbed by the cooling fins 128 .

Based on the above, the heat dissipation device of the present invention is not limited to the embodiments disclosed in Figs. cycle device.

Next, please refer to FIG. 8 first. In order to irradiate the lumen of the human body, such as the oral cavity, esophagus, etc., the light source generator 100 of the medical device according to the present invention can be further configured with a light guide column 160. The light guide column The body 160 has a light incident surface 161 and a corresponding light exit surface 162, and the light incident surface 161 of the light guide column 160 is coupled with the high-power light-emitting diode 110, and the light emitted by the high-power light-emitting diode 110 can be emitted by the light-entrance The surface 161 enters into the light guide cylinder 160 , is guided by the light guide cylinder 160 , and finally emerges from the light exit surface 162 . In addition, one embodiment of the surface shape of the light incident surface 161 and the light exit surface 162 of the light guide cylinder 160 is a flat surface perpendicular to the optical axis of the light guide cylinder 160 .

In addition, please refer to FIG. 9 , the light incident surface 161 of the light guide cylinder 160 can also be changed into a curved surface to focus the light emitted by the high-power LED 110 into the light guide cylinder 160 to reduce light loss rate.

Furthermore, please refer to FIG. 10 , the light emitting surface 162 of the light guide cylinder 160 can also be changed into a tapered surface, so that the light emitted from the light emitting surface 162 has a diffusion effect, thereby increasing the area irradiated by light.

In FIGS. 8-10 , regardless of the shape of the light-emitting surface 162 of the light-guiding cylinder 160 , the surface can be further roughened and atomized to make the emitted light uniform. In addition, the light guide column 160 is made of optical fiber in this embodiment, of course, the light guide column 160 can also be glass, acrylic, optical polyethylene (PE) or other high penetration materials such as polycarbonate ( PC) or light guide elements such as polymethyl methacrylate (PMMA).

In addition, it is worth noting that generally to guide light into the light guide cylinder 160 (such as an optical fiber), the angle of the light must conform to the numerical aperture (NA; numerical aperture) of the light guide cylinder 160 (such as an optical fiber), and the high The power light-emitting diode can be packaged through the design of the relative position between the reflector cup and the bracket (leadframe with reflector cup) and the mold (molding), so that the light output angle conforms to the numerical aperture of the light guide cylinder 160 (such as an optical fiber). In this way, That is, no additional optical lens is needed to collect light, so the difficulty of assembly can be reduced.

The above descriptions are only preferred embodiments of the present invention, and are not intended to limit the present invention. For those skilled in the art, the present invention may have various modifications and changes. Any modifications, equivalent replacements, improvements, etc. made within the spirit and principles of the present invention shall be included within the protection scope of the present invention.

Claims (15)

1. A light source generator (100) for medical equipment, characterized in that the light source generator (100) for medical equipment comprises: A high-power light-emitting diode (110), which is suitable for emitting high-brightness light of a specific wavelength, to diagnose or treat the affected part; and A heat dissipation device is in contact with the high-power light-emitting diode (110), and is used for taking away heat energy generated when the high-power light-emitting diode (110) emits light. 2. The light source generator (100) for medical equipment according to claim 1, characterized in that the heat dissipation device is at least one heat dissipation fin (121). 3. The light source generator (100) for medical equipment according to claim 2, characterized in that the heat dissipation device further comprises a fan (122), and the fan is arranged on the heat dissipation fins (121). 4. The light source generator (100) for medical equipment according to claim 1, characterized in that, the heat dissipation device is at least a thermoelectric cooler (123), and the thermoelectric cooler (123) has a cooling end (123a) and a hot end (123b), and the high-power light emitting diode (110) is arranged on the cold end (123a). 5. The light source generator (100) for medical equipment according to claim 4, wherein the heat dissipation device further comprises a heat dissipation fin (124), and the heat dissipation fin (124) is arranged on the on the hot end (123b). 6. The light source generator (100) for medical equipment according to claim 5, wherein the heat dissipation device further comprises a fan (125), and the fan (125) is arranged on the heat dissipation fins ( 124) on. 7. The light source generator (100) for medical equipment according to claim 1, characterized in that, the heat dissipation device is at least one heat pipe (127), and one end of the heat pipe (127) is disposed on the High Power Light Emitting Diodes (110). 8. The light source generator (100) for medical equipment according to claim 7, characterized in that the heat dissipation device further comprises a heat dissipation fin (128), and the heat dissipation fin (128) is arranged on the On the other end of heat pipe (127). 9. The light source generator (100) for medical equipment according to claim 8, wherein the heat dissipation device further comprises a fan (129), and the fan (129) is arranged on the heat dissipation fins ( 128) on. 10. The light source generator (100) for medical equipment according to claim 1, characterized in that the heat dissipation device is a water-cooled heat dissipation circulation device. 11. The light source generator (100) for medical equipment according to claim 1, further comprising a light guide cylinder (160), the light guide cylinder (160) having a light incident surface (161) and A corresponding light exit surface (162), and the light incident surface (161) of the light guide column (160) is coupled with the high power light emitting diode (110). 12. The light source generator (100) for medical equipment according to Claim 11, characterized in that the light incident surface (161) is a flat surface, a curved surface, or a conical surface. 13. The light source generator (100) for medical equipment according to Claim 11, characterized in that, the light exit surface (162) is a straight surface, a curved surface, or a conical surface. 14. The light source generator (100) for medical equipment according to Claim 13, characterized in that, the light output surface (162) is a rough surface or a fogged surface. 15. The light source generator (100) for medical equipment according to claim 1, characterized in that, a heat-conducting adhesive (150) can be coated between the high-power light-emitting diode (110) and the heat dissipation device.

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