CN1947699A - Method for producing water soluble fluorophenylnico - Google Patents
Method for producing water soluble fluorophenylnico Download PDFInfo
- Publication number
- CN1947699A CN1947699A CN 200610069970 CN200610069970A CN1947699A CN 1947699 A CN1947699 A CN 1947699A CN 200610069970 CN200610069970 CN 200610069970 CN 200610069970 A CN200610069970 A CN 200610069970A CN 1947699 A CN1947699 A CN 1947699A
- Authority
- CN
- China
- Prior art keywords
- florfenicol
- water
- solubility
- powder
- pure powder
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000004519 manufacturing process Methods 0.000 title claims description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 title description 5
- AYIRNRDRBQJXIF-NXEZZACHSA-N (-)-Florfenicol Chemical compound CS(=O)(=O)C1=CC=C([C@@H](O)[C@@H](CF)NC(=O)C(Cl)Cl)C=C1 AYIRNRDRBQJXIF-NXEZZACHSA-N 0.000 claims abstract description 36
- 229960003760 florfenicol Drugs 0.000 claims abstract description 35
- 239000000843 powder Substances 0.000 claims abstract description 21
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims abstract description 8
- 239000008103 glucose Substances 0.000 claims abstract description 8
- 239000003814 drug Substances 0.000 claims description 4
- 150000001875 compounds Chemical class 0.000 claims description 3
- 239000002904 solvent Substances 0.000 claims 1
- 238000003756 stirring Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 description 5
- 241001465754 Metazoa Species 0.000 description 4
- 241000894006 Bacteria Species 0.000 description 3
- WIIZWVCIJKGZOK-RKDXNWHRSA-N chloramphenicol Chemical compound ClC(Cl)C(=O)N[C@H](CO)[C@H](O)C1=CC=C([N+]([O-])=O)C=C1 WIIZWVCIJKGZOK-RKDXNWHRSA-N 0.000 description 3
- 229940097572 chloromycetin Drugs 0.000 description 3
- 208000015181 infectious disease Diseases 0.000 description 3
- 206010022678 Intestinal infections Diseases 0.000 description 2
- 229930193140 Neomycin Natural products 0.000 description 2
- 230000003115 biocidal effect Effects 0.000 description 2
- 229960003722 doxycycline Drugs 0.000 description 2
- XQTWDDCIUJNLTR-CVHRZJFOSA-N doxycycline monohydrate Chemical compound O.O=C1C2=C(O)C=CC=C2[C@H](C)[C@@H]2C1=C(O)[C@]1(O)C(=O)C(C(N)=O)=C(O)[C@@H](N(C)C)[C@@H]1[C@H]2O XQTWDDCIUJNLTR-CVHRZJFOSA-N 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 229960004927 neomycin Drugs 0.000 description 2
- 244000144977 poultry Species 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 208000031295 Animal disease Diseases 0.000 description 1
- 208000032467 Aplastic anaemia Diseases 0.000 description 1
- 241000193830 Bacillus <bacterium> Species 0.000 description 1
- 208000035143 Bacterial infection Diseases 0.000 description 1
- 241000192125 Firmicutes Species 0.000 description 1
- 201000009906 Meningitis Diseases 0.000 description 1
- 241001597008 Nomeidae Species 0.000 description 1
- 206010034107 Pasteurella infections Diseases 0.000 description 1
- 241000607142 Salmonella Species 0.000 description 1
- 241000531795 Salmonella enterica subsp. enterica serovar Paratyphi A Species 0.000 description 1
- 241000293871 Salmonella enterica subsp. enterica serovar Typhi Species 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 230000000843 anti-fungal effect Effects 0.000 description 1
- 229940121375 antifungal agent Drugs 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 208000022362 bacterial infectious disease Diseases 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000035622 drinking Effects 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000000857 drug effect Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000011812 mixed powder Substances 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 201000005115 pasteurellosis Diseases 0.000 description 1
- 208000008423 pleurisy Diseases 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 210000002345 respiratory system Anatomy 0.000 description 1
- 208000023504 respiratory system disease Diseases 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 239000000273 veterinary drug Substances 0.000 description 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
A water-soluble florfenicol with high solubility (10000 PPM) and low cost is prepared from florfenicol powder and glucose powder through proportional mixing and stirring.
Description
Technical field
The present invention relates to the production method of veterinary drug, the water miscible production method of antibiotic florfenicol for animals particularly of new generation.
Background technology
Florfenicol claims Florfenicol, Sch-25298 again.Be spirit-Schering-Plough of U.S. elder generation the end of the seventies be to seek the new product developed in the better chloromycetin derivant, successively go on the market in a plurality of countries in Europe such as Japan, Korea S, Norway, France.Florfenicol is a chloromycetin veterinary special broad-spectrum antibiotic of new generation, have the characteristics such as wide, safe and efficient that distribute in the has a broad antifungal spectrum, good absorbing, body, remarkable for the poultry bacterial disease therapeutic effect due to the sensitive organism, gram positive bacteria and negative bacterium are all had effect, are the drug of first choices of the various infection that cause of Bacillus typhi, Salmonella paratyphi, Salmonella.Because chloromycetin has the untoward reaction of serious induced aplastic anemia, has forbidden being used for food animal, therefore, on animal diseases control, food animal especially, florfenicol has broad application prospects.But the former powder of florfenicol is a kind of water insoluble and can only be dissolved in the partly medicine of organic solvent, so its dosing way is very limited, develops water-solubility florfenicol and has the very strong market advantage.
Summary of the invention
The objective of the invention is to find out that a kind of technology is simple, cost is lower and the production method of the production water-solubility florfenicol that product quality is good.
The production method that this simplified method is produced high-quality water-solubility florfenicol promptly is to make mixing by a certain percentage after pure powder of florfenicol and the pure powder oven dry of glucose.
Thisly can be processed into various concentration according to actual needs with the mixed water-solubility florfenicol of glucose by a certain percentage, add a certain amount of water and then make the drinking agent of various concentration, injection, also available mixed powder is admixed in the feedstuff, be used for the treatment of poultry and aquatic animal because of bacterial each site infection of whole body, as the bacillary respiratory system disease of pig, horse etc., meningitis, pleuritis, intestinal infection and postpartum syndrome etc.The respiratory system of birds, intestinal infection, the infection that the pasteurellosis bacillus of Fish, golden Portugal bacterium and other gram negative bacteria cause.This water solublity medicinal liquid quality is good, no flocky precipitate.The florfenicol dissolubility that this method is produced can be brought up to 10000PPM.Because adjuvant is few, technology is simple, need are few with equipment, and this water-solubility florfenicol production cost water-solubility florfenicol commercially available medicine production cost more in the market can reduce by 20%.Drug effect then is higher than the latter.
The specific embodiment
The present invention will be further described to list a youngster embodiment below.
As to produce 100 kilograms of concentration be 10% water-solubility florfenicol powder, makes after available 10 kilograms of pure powder of florfenicol and 90 kilograms of pure powder oven dry of glucose mix.
As produce 100 kilograms of compound recipe water-solubility florfenicol powder, and wherein florfenicol contains 10%, and doxycycline contains 10%.Available 10 kilograms of pure powder of florfenicol and 80 kilograms of pure powder oven dry of glucose mix makes the water-solubility florfenicol powder, adds and makes after 10 kilograms of pure powder of doxycycline mix.
As produce 100 kilograms of compound recipe water-solubility florfenicol powder, and wherein florfenicol contains 10%, and neomycin contains 20%.Available 10 kilograms of pure powder of florfenicol and 70 kilograms of pure powder oven dry of glucose mix makes the water-solubility florfenicol powder, adds and makes after 20 kilograms of pure powder of neomycin mix.
Claims (3)
1. the production method of water-solubility florfenicol is made after it is characterized in that the pure powder of florfenicol and the pure powder of glucose mixed by a certain percentage.
2. the production method of water-solubility florfenicol as claimed in claim 1 is characterized in that wherein.Only just can produce water-solubility florfenicol fully as the solubilizing agent of florfenicol with the pure powder of glucose.
3. the production method of water-solubility florfenicol as claimed in claim 1 is produced water-solubility florfenicol and is added other medicine for the basis, does the compound recipe water-solubility florfenicol.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200610069970 CN1947699A (en) | 2006-11-04 | 2006-11-04 | Method for producing water soluble fluorophenylnico |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200610069970 CN1947699A (en) | 2006-11-04 | 2006-11-04 | Method for producing water soluble fluorophenylnico |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1947699A true CN1947699A (en) | 2007-04-18 |
Family
ID=38017389
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200610069970 Pending CN1947699A (en) | 2006-11-04 | 2006-11-04 | Method for producing water soluble fluorophenylnico |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1947699A (en) |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009061780A1 (en) * | 2007-11-09 | 2009-05-14 | Schering-Plough Limited | Fast release solid formulation, preparation and use thereof |
| CN101843586A (en) * | 2010-04-29 | 2010-09-29 | 山东迅达康兽药有限公司 | Water-soluble micro powder containing florfenicol and preparation method thereof |
| CN102068443A (en) * | 2011-01-11 | 2011-05-25 | 清远海贝生物技术有限公司 | Compound florfenicol preparation for aquatic products and preparation method and application thereof |
| CN102743400A (en) * | 2012-07-19 | 2012-10-24 | 河北农业大学 | Pharmaceutical composition for preventing and treating turbot white feces disease |
| CN104173374A (en) * | 2014-07-25 | 2014-12-03 | 邳州正康生物技术有限公司 | Formula and preparation method of florfenicol powder |
| CN107233315A (en) * | 2017-05-10 | 2017-10-10 | 刘淑鹤 | Florfenicol soluble powder, Florfenicol liquid and preparation method thereof |
| CN109498580A (en) * | 2018-12-13 | 2019-03-22 | 广东温氏大华农生物科技有限公司 | A kind of Florfenicol granular preparation and its preparation process |
-
2006
- 2006-11-04 CN CN 200610069970 patent/CN1947699A/en active Pending
Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009061780A1 (en) * | 2007-11-09 | 2009-05-14 | Schering-Plough Limited | Fast release solid formulation, preparation and use thereof |
| JP2011503083A (en) * | 2007-11-09 | 2011-01-27 | インターベット インターナショナル ベー． フェー． | Rapid release liquid formulations, preparations and uses thereof |
| US7968599B2 (en) | 2007-11-09 | 2011-06-28 | Intervet International B.V. | Fast release solid formulation, preparation and use thereof |
| CN101843586A (en) * | 2010-04-29 | 2010-09-29 | 山东迅达康兽药有限公司 | Water-soluble micro powder containing florfenicol and preparation method thereof |
| CN101843586B (en) * | 2010-04-29 | 2012-05-23 | 山东迅达康兽药有限公司 | Water-soluble micro powder containing florfenicol and preparation method thereof |
| CN102068443A (en) * | 2011-01-11 | 2011-05-25 | 清远海贝生物技术有限公司 | Compound florfenicol preparation for aquatic products and preparation method and application thereof |
| CN102068443B (en) * | 2011-01-11 | 2012-06-27 | 清远海贝生物技术有限公司 | Compound florfenicol preparation for aquatic products and preparation method and application thereof |
| CN102743400A (en) * | 2012-07-19 | 2012-10-24 | 河北农业大学 | Pharmaceutical composition for preventing and treating turbot white feces disease |
| CN102743400B (en) * | 2012-07-19 | 2013-05-22 | 河北农业大学 | Pharmaceutical composition for preventing and treating turbot white feces disease |
| CN104173374A (en) * | 2014-07-25 | 2014-12-03 | 邳州正康生物技术有限公司 | Formula and preparation method of florfenicol powder |
| CN107233315A (en) * | 2017-05-10 | 2017-10-10 | 刘淑鹤 | Florfenicol soluble powder, Florfenicol liquid and preparation method thereof |
| CN109498580A (en) * | 2018-12-13 | 2019-03-22 | 广东温氏大华农生物科技有限公司 | A kind of Florfenicol granular preparation and its preparation process |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Open date: 20070418 |