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CN1870985B - 用hdac抑制剂治疗癌症的方法 - Google Patents

用hdac抑制剂治疗癌症的方法 Download PDF

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Publication number
CN1870985B
CN1870985B CN2004800313068A CN200480031306A CN1870985B CN 1870985 B CN1870985 B CN 1870985B CN 2004800313068 A CN2004800313068 A CN 2004800313068A CN 200480031306 A CN200480031306 A CN 200480031306A CN 1870985 B CN1870985 B CN 1870985B
Authority
CN
China
Prior art keywords
saha
pharmaceutically acceptable
dose
administered
hdac inhibitor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN2004800313068A
Other languages
English (en)
Chinese (zh)
Other versions
CN1870985A (zh
Inventor
N·G·巴科波洛斯
J·H·奇奥
T·A·米勒
C·M·帕拉迪塞
V·M·里奇翁
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck HDAC Research LLC
Memorial Sloan Kettering Cancer Center
Original Assignee
Memorial Sloan Kettering Cancer Center
Aton Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/650,025 external-priority patent/US7148257B2/en
Priority claimed from US10/665,079 external-priority patent/US20040127523A1/en
Application filed by Memorial Sloan Kettering Cancer Center, Aton Pharma Inc filed Critical Memorial Sloan Kettering Cancer Center
Priority claimed from PCT/US2004/027943 external-priority patent/WO2005018578A2/en
Publication of CN1870985A publication Critical patent/CN1870985A/zh
Application granted granted Critical
Publication of CN1870985B publication Critical patent/CN1870985B/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN2004800313068A 2003-08-26 2004-08-26 用hdac抑制剂治疗癌症的方法 Expired - Fee Related CN1870985B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US10/650,025 US7148257B2 (en) 2002-03-04 2003-08-26 Methods of treating mesothelioma with suberoylanilide hydroxamic acid
US10/650,025 2003-08-26
US10/665,079 2003-09-16
US10/665,079 US20040127523A1 (en) 2002-03-04 2003-09-16 Methods of treating cancer with HDAC inhibitors
PCT/US2004/027943 WO2005018578A2 (en) 2003-08-26 2004-08-26 Method of treating cancer with hdac inhibitors

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN201110072778XA Division CN102188415A (zh) 2003-08-26 2004-08-26 用hdac抑制剂治疗癌症的方法

Publications (2)

Publication Number Publication Date
CN1870985A CN1870985A (zh) 2006-11-29
CN1870985B true CN1870985B (zh) 2011-11-30

Family

ID=37444418

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2004800313068A Expired - Fee Related CN1870985B (zh) 2003-08-26 2004-08-26 用hdac抑制剂治疗癌症的方法

Country Status (5)

Country Link
CN (1) CN1870985B (is)
CY (1) CY1110659T1 (is)
IS (1) IS8357A (is)
UA (1) UA83065C2 (is)
ZA (1) ZA200601589B (is)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ592686A (en) 2008-10-15 2012-12-21 Generics Uk Ltd Process for the preparation of vorinostat from aniline, hydroxylamine and suberic acid starting materials
CN103159646B (zh) * 2013-03-19 2014-10-22 广东药学院 一种异羟肟酸类化合物及其制备方法和应用
CN104292134B (zh) * 2014-10-10 2016-06-22 广东药学院 异羟肟酸类化合物及其制备方法和应用
CN109705057B (zh) * 2017-10-25 2023-05-30 成都先导药物开发股份有限公司 组蛋白去乙酰化酶抑制剂及其制备方法与用途
CN111973590A (zh) * 2020-07-06 2020-11-24 江苏省人民医院（南京医科大学第一附属医院） 新型hdac抑制剂laq824在治疗弥漫大b细胞淋巴瘤药物中的应用

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Kelly W.et al.A phase I clinical of an oral formulation of the histonedeacetylase inhibitor suberoylanilide hydroxamic acid(SAHA).European Journal of CancerVol.38.2002,Vol.38S88. *

Also Published As

Publication number Publication date
CY1110659T1 (el) 2015-06-10
CN1870985A (zh) 2006-11-29
ZA200601589B (en) 2007-05-30
UA83065C2 (ru) 2008-06-10
IS8357A (is) 2006-03-17

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Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
ASS Succession or assignment of patent right

Owner name: MERCK HDAC RESEARCH CO.,LTD.; APPLICANT

Free format text: FORMER OWNER: ATON PHARMA INC; APPLICANT

Effective date: 20071123

C41 Transfer of patent application or patent right or utility model
TA01 Transfer of patent application right

Effective date of registration: 20071123

Address after: Massachusetts

Applicant after: Merck Hdac Res Llc

Co-applicant after: Sloan-Kettering Institute For Cancer Research

Address before: Massachusetts

Applicant before: Aton Pharma Inc.

Co-applicant before: Sloan-Kettering Institute For Cancer Research

C14 Grant of patent or utility model
GR01 Patent grant
C17 Cessation of patent right
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20111130

Termination date: 20120826