CN1868535A - Medicine composition for treating rheumatic arthritis and rheumatoid arthritis, and its prepn. method - Google Patents
Medicine composition for treating rheumatic arthritis and rheumatoid arthritis, and its prepn. method Download PDFInfo
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- CN1868535A CN1868535A CNA2005100722865A CN200510072286A CN1868535A CN 1868535 A CN1868535 A CN 1868535A CN A2005100722865 A CNA2005100722865 A CN A2005100722865A CN 200510072286 A CN200510072286 A CN 200510072286A CN 1868535 A CN1868535 A CN 1868535A
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- 201000003068 rheumatic fever Diseases 0.000 title 1
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Abstract
A Chinese medicine for treating rheumatic and rheumatoid arthiritides is prepared from 32 Chinese-medicinal materials including vomiting nut, scorpion, white atractylodes rhizome, borneol, etc. Its preparing process is also disclosed.
Description
Technical field
The present invention relates to a kind of pharmaceutical composition, particularly relate to a kind of pharmaceutical composition for the treatment of rheumatism atrophic arthritis and preparation method thereof.
Background technology
Rheumatoid arthritis, be that a kind of articular synovitis is the chronic symmetry arthritis of feature, show as local red and swollen heating, pain, belonging to systemic chronic autoimmune disease, is clinical common altauna disease, and traditional medicine is thought the exopathogenic factor damp and hot heresy that is affected by the cold, it is moist to live, paddle in spite of the rain, unusual weather conditions, cold and hot reason such as staggered so that pathogen invasion muscle joint, meridians and falling ill; The endogenous cause of ill natural endowment is plain loses, and deficiency of both the liver and kidney will be transferred imbalance of YIN and YANG, the day after tomorrow and feared accidentally, deficiency of qi and blood, and lose blood puerperal, and work and rest excessively causes liver, kidney, spleen three deficiency of five ZANG-organs decrease, and three dirty functions are closely related.The kidney being the origin of congenital constitution, store essential substances, gives birth to marrow, nourishes blood, and bone is supported by marrow, the brain inanition, bone is become homeless foster, support unable because kidney keeps " congenital essence ", for the internal organs negative and positive this, Source of life, congenital essence also depend on the acquired essence taste and absorb constantly replenishing with changing of essence of water and grain material and give birth to.The spleen being the foundation of acquired constitution, source of generating QI and blood, main limb muscle is worked as dysfunction of the spleen in transportation, undernutrition, muscle atrophia then, extremity lassitude.Deficiency of spleen-QI, digestive and absorptive functions are unstrong, and blood does not have the source of vital function, and causes deficiency of liver-blood.And spleen is very close with the relation of liver, and blood stored in the liver, the main all muscle of system are regulated blood volume.Deficiency of liver-blood, muscle arteries and veins lose supports, and then muscles and bones apathy, muscle arteries and veins contracture flaccidity contract, arthroncus is abnormal.Shape, vigor are limited, joint stuffiness." element is asked the flaccidity opinion " said: " the liver being in charge of the tendons ".Liver why can main body fascia; Depend on the nourishing of liver blood mainly due to fascia.Have only liver blood full, ability " excess of QI is in muscle " makes fascia obtain moistening and supports and keep normal limb motion.Liver blood full vigorous depends on the strong fortune of temper again, QI and blood biochemistry active, and " essence and blood sharing the same origin " " The liver and the kidney have a common source " simultaneously, and liver blood relies on the nourishing of kidney essense, the filling of the smart essence that also constantly obtains liver blood and changed, thus keep the balance of negative and positive.Smart grow mutually with blood, when deficiency of the kidney deficiency of liver-blood then, deficiency of liver-blood also can cause deficiency of the kidney. therefore, work as liver, and kidney, spleen three deficiency of five ZANG-organs decrease, deterioration, biochemical dereliction of duty causes imbalances mutually such as internal organs, gas, blood, battalion defend, and is yin or yang excess, decline partially; Thereby causing hypoimmunity, is the main root that forms rheumatoid arthritis, and rheumatoid arthritis is because QI and blood is lost few, stasis circumfluence is not smooth, and phlegm and blood stasis is between bone and cause arthroncus, muscle atrophia, stiff, deformity, the pain journey heals the serious threat mankind's physical and mental health than long and touching difficulty.For this reason, purpose of the present invention is foundation at modern immunology theory with the Chinese medicine theory, strengthening vital QI to eliminate pathogenic factors, invigorating the spleen and benefiting QI is enriched blood, promoting blood circulation to remove obstruction in the collateral, nourishing the liver and kidney, Yin Yang balancing returns originally returns unit to be the treatment rule, thus enhancing human body immunity ability Cause ﹠ Symptom Solution, and oral administration and externally is in conjunction with through sick institute, strengthen anti-inflammation detumescence, analgesic effect, reach the characteristics that do not recur after healing.
Summary of the invention
The object of the invention is to provide a kind of pharmaceutical composition that rheumatism atrophic arthritis has remarkable result for the treatment of.
Another object of the present invention is to provide a kind of preparation of drug combination method that rheumatism atrophic arthritis has remarkable result for the treatment of.
The present invention is achieved through the following technical solutions: choose crude drug
Semen Strychni (processed) 40-60 weight portion Scorpio 60-80 weight portion Rhizoma Atractylodis Macrocephalae 60-80 weight portion
Radix Saposhnikoviae 60-80 weight portion Rhizoma Anemarrhenae 30-50 weight portion Borneolum Syntheticum 3-5 weight portion
Os pardi 80-120 weight portion Squama Manis 60-80 weight portion Poria 60-80 weight portion
Sinomenium acutum 80-120 weight portion Formica fusca 100-160 weight portion Agkistrodon 10-20 weight portion
Sanguis Draxonis 80-100 weight portion Radix Rehmanniae Preparata 100-120 weight portion Spina Gleditsiae 30-50 weight portion
Cornu rhinocerotis 10-20 weight portion Radix Tripterygii Wilfordii tablet 10-30 weight portion Radix Notoginseng 60-80 weight portion
Radix Ginseng 40-60 weight portion Radix Rehmanniae 100-120 weight portion Radix Aconiti Preparata 60-80 weight portion
Herba Asari 30-50 weight portion Hirudo 60-80 weight portion Radix Astragali 100-120 weight portion
Cornu Cervi Pantotrichum 20-30 weight portion Herba Ephedrae 20-40 weight portion Ganoderma 30-50 weight portion
Scolopendra 20-40 weight portion Radix Angelicae Sinensis 60-80 weight portion hippocampus 3 0-60 weight portion
Olibanum 30-50 weight portion Flos Lonicerae 50-70 weight portion Catharsii molossi 60-80 weight portion
Radix Paeoniae Alba 60-80 weight portion Solenognathus 30-60 weight portion Myrrha 30-50 weight portion
Radix Glycyrrhizae 20-50 weight portion ground beetle 60-80 weight portion Rhizoma Chuanxiong 60-80 weight portion
Colla Plastri Testudinis 60-80 weight portion Cortex Phellodendri 30-50 weight portion Moschus 1-3 weight portion
The optimum ratio of pharmaceutical composition of the present invention is: choose crude drug
The Semen Strychni (processed) 50 weight portion Scorpio 70 weight portion Rhizoma Atractylodis Macrocephalaes 70 weight portions
The Radix Saposhnikoviae 70 weight portion Rhizoma Anemarrhenaes 40 weight portion Borneolum Syntheticums 4 weight portions
Os pardi 100 weight portion Squama Maniss 70 weight portion Poria 70 weight portions
Sinomenium acutum 100 weight portion Formica fuscas 130 weight portion Agkistrodons 15 weight portions
Sanguis Draxonis 90 weight portion Radix Rehmanniaes Preparata 110 weight portion Spina Gleditsiae 40 weight portions
Cornu rhinocerotis 15 weight portion Radix Tripterygii Wilfordii tabletes 20 weight portion Radix Notoginseng 70 weight portions
The Radix Ginseng 50 weight portion Radix Rehmanniae 110 weight portion Radix Aconiti Preparatas 70 weight portions
The Herba Asari 40 weight portion Hirudos 70 weight portion Radixs Astragali 110 weight portions
Cornu Cervi Pantotrichum 25 weight portion Herba Ephedraes 30 weight portion Ganoderma 40 weight portions
Scolopendra 30 weight portion Radix Angelicae Sinensis 70 weight portion Hippocampus 45 weight portions
Olibanum 40 weight portion Flos Loniceraes 60 weight portion Catharsii molossis 70 weight portions
The Radix Paeoniae Alba 70 weight portion Solenognathus 45 weight portion Myrrhas 40 weight portions
Radix Glycyrrhizae 35 weight portion ground beetles 70 weight portion Rhizoma Chuanxiongs 70 weight portions
Colla Plastri Testudinis 70 weight portion Cortex Phellodendris 40 weight portion Moschus 2 weight portions
Described Os pardi can substitute with zokor bone or Bailey Myospalax Born; Described Spina Gleditsiae can substitute with Bombyx Batryticatus; Described Cornu rhinocerotis can substitute with Cornu Saigae Tataricae or Cornu Bubali; Described Radix Tripterygii Wilfordii tablet can substitute with the Radix Tripterygii Wilfordii extractum of conventional method preparation; The preferred shallow bid of described Agkistrodon footpath Agkistrodon.
Preparation of drug combination method of the present invention is: with Semen Strychni (processed) fried or stir-baking with sand to the outside pale brown color, 2 times of Semen Strychni are arranged for good during expansion, it is standby to grind superfine mistake 100 mesh sieves; Sinomenium acutum must be fried with 250-400 weight portion rice wine; Be good with explosive sound when method treats that pot is put into pure rice wine when red, fry do after, fry 5-9 time altogether, drying is beaten superfine powder, and to cross 100 mesh sieves standby; The Os pardi stir-baking with sand is to the buff shakeout, pours the Chinese liquor stain while hot into and quenches, and take out after the roasting heat again stain and quench, 2-4 time repeatedly, extremely crisp, cool, it is standby to break into fine powder; Catharsii molossi, ground beetle baking grind to the powder standby; Scorpio, Scolopendra spray Chinese liquor baking drying, it is standby to grind to the powder; Hirudo cutting sheet is fried to little heaving with Talcum, and it is standby that sieve goes Pulvis Talci to grind to the powder; Squama Manis stir-baking with sand system is heaved when being golden yellow, takes out, and the sieve sand that deoils immediately with in the Squama Manis impouring 30-40 weight portion vinegar basin, stirs and slightly soaks, and pulls out to dry with water rinse and beats superfine end to cross 100 mesh sieves standby; Cornu Cervi Pantotrichum, Agkistrodon, Hippocampus, Solenognathus use yellow wine moistening, and little to be baked to the loose yellow that is, it is standby that the mill impalpable powder is crossed 100 mesh sieves; The Radix Rehmanniae, Radix Rehmanniae Preparata shave, oven dry grinds to the powder; Radix Notoginseng, the Radix Astragali, Radix Ginseng section are ground into powder, and Radix Saposhnikoviae, Spina Gleditsiae, Radix Aconiti Preparata grind to the powder standby by traditional method process of preparing Chinese medicine detoxification, and Herba Ephedrae, Cortex Phellodendri, Herba Asari decontamination grind to the powder standby; Turn to saline with 9-15 weight portion salt, the Rhizoma Anemarrhenae is got final product with dried the grinding to the powder of slow fire stir-fry with the saline profit is rare; Flos Lonicerae, Radix Glycyrrhizae are dried 100 mesh sieves that ground to the powder, and Ganoderma shave oven dry porphyrize is standby; Olibanum, Myrrha use the slow fire parch molten slightly respectively, and spray vinegar continues to stir to coke black, take out and cool 100 mesh sieves that ground to the powder; The Radix Tripterygii Wilfordii tablet porphyrize uses; The Rhizoma Atractylodis Macrocephalae, Borneolum Syntheticum, Poria, Formica fusca, Sanguis Draxonis, Spina Gleditsiae, Cornu rhinocerotis, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Rhizoma Chuanxiong, Colla Plastri Testudinis, Moschus are ground into fine powder to be mixed with above-mentioned gained material and stirs, under 100 degrees centigrade, sterilize, handle after 20-30 minute, add conventional adjuvant or tablet, the watered pill, honeyed pill, capsule, granule dosage form etc. are made in the agent of figuration material.
The conventional adjuvant that pharmaceutical composition of the present invention adds is pharmaceutically made clinical acceptable forms, as in tablet, suppository, capsule, granule, spray, ointment, emplastrum or the ointment any.
The present composition has that invigorating the spleen and benefiting QI is enriched blood, damp eliminating is reduced phlegm, dispersing swelling and dissipating binds, dredge the meridian passage, analgesia, nourishing the liver and kidney, Yin Yang balancing, return the effect of originally returning unit, enhancing human body immunity function and resistance against diseases, and can remove the puzzlement of hormone rapidly, the characteristics that do not recur after making rheumatoid arthritis reach more.Pharmaceutical composition of the present invention is evident in efficacy, and no matter negative and positive are deficient, deficiency of qi and blood, and coldheat complex, course of disease patient with rheumatoid arthritis remote all can use, and effect is splendid, and and lasting, safe and reliable, side effect is little rapidly in effect.And to ankylosing spondylitis, aseptic osteonecrosis, hyperosteogeny diseases all has good effect.
Following experimental example is used to further specify the present invention:
Clinical data
1, physical data
Pharmaceutical composition clinical observation of the present invention is rheumatoid arthritis patients 98 examples in various degree, male's 35 examples wherein, women's 63 examples, the oldest person 68 years old, minimum 17 years old, the course of disease is the longest 25 years, the shortest 6 months, result of laboratory test rheumatoid factor (RF) is all positive, and wherein the joint is scorching hot, red and swollen, deformity, bony ankylosis, amyotrophy function of joint serious hindrance person 24 examples, anemia person's 61 examples in various degree, erythrocyte sedimentation rate quickening person 37 examples, the heart, lung, eye impairer 13 examples, renal damage person 6 examples, women's menoxenia, the infrequent menstruation color is dark, person's 31 examples that have the piece.
2, diagnostic criteria
All according to 1987 American Rheumatism Association (ARA) diagnostic criteria.
3, Therapeutic Method:
98 routine rheumatoid joints, scorching patient all stops using other all medicines, all uses the fine and soft ball of kylin of the present invention breast, each 8 grams of the lighter for oral administration, each 10 grams of heavy person, every day three times, warm water delivery service after meal, one month is a course of treatment.
4, treatment standard:
1. cure: symptom all disappears, and limb function is normal, recovers former work, the chemical examination rheumatoid factor negative, and erythrocyte sedimentation rate is normal.2. take a turn for the better: symptom disappears substantially, and joint movement function recovers substantially, can participate in manual labor, and experimental check makes moderate progress, and is 3. invalid: symptom and sign and assay do not have significant change,
5, therapeutic outcome (seeing table)
| The course of disease (month year) | Case load (people) | Cure | Effectively | Invalid |
| 6 months-4 years 5 years-11 years 12 years-25 years effective percentage | 32 29 37 | 30 24 23 78.57％ | 2 5 14 21.43％ | 0 0 0 0％ |
6, conclusion
From above-mentioned clinical data as seen, medicine treating both the principal and secondary aspects of a disease of the present invention, vigorate qi and replenish the blood, Yin Yang balancing, nourishing the liver and kidney is repaid principal and is returned unit, strengthens the antibody mediated immunity ability, the purpose that does not recur after guaranteeing to heal.Inside and outside double executing brought out the best in each other, and remedied the deficiency of present like product, solved the root problem that rheumatoid arthritis shows effect repeatedly.
7, model case:
Case 1: the king * *, man, 25 years old, the peasant, the Mei Ping of Suining County township moth people from village, first visit on January 3 in 2000, the patient is water cultivated land under in mid-April, 95, finger-joint occurs after several days, the knee joint congestion and swelling pain, after relate to neck, waist, toe joint is whenever Changes in weather or wear the galosh operation for a long time, the state of an illness increases the weight of, and western medicines in treatment is invalid through hospital, satisfies and comes me to go to a doctor, look into two finger-joint rednesses, knee joint, ankle, the toe joint swelling pain, aversion to cold and cold limbs, stool is normal, frequent micturition, pale tongue, white and thin fur, slow pulse is slow, through the chemical examination of Dongkou County the People's Hospital, the rheumatoid factor positive, erythrocyte sedimentation rate 60mm/h, anti-" 0 " 640n is diagnosed as rheumatoid arthritis, clothes are with the fine and soft ball of kylin breast of the present invention, every day three times, each 8 the gram, 6 the course of treatment symptom and sign all disappear, chemical examination is normal, follows up a case by regular visits to not recurrence in 2 years.
Case 2: dragon * *, woman, 54 years old, Dongkou County area just outside a city gate town resident, calendar year 2001 first visit on April 17, the pre-marital two knee joint pain of patient, after involve finger, ankle, toe joint, through Chinese and Western in conjunction with and during the DAHUOLUO WAN treatment time slack heavy, nearly section relates to neck, shoulder, elbow, lumbar vertebra, and especially both shoulders are attached most importance to, the difficulty of undressing.Companion's kidney damage, soreness of the waist and knees, when the heating of brothers' heart is no, light red tongue, tongue is few, a little less than the deep-thready pulse.Nikkei Dongkou County the People's Hospital chemical examination in April 4 calendar year 2001: the rheumatoid factor positive, erythrocyte sedimentation rate 34mm/h, anti-" 0 " feminine gender, be diagnosed as rheumatoid arthritis, through the fine and soft ball of clothes kylin breast of the present invention, every day three times, each 10 grams are treated 8 recoveries from illness course of treatment, follow up a case by regular visits to not recurrence in 2 years.
Case 3 poplars * *, woman, 27 years old, the peasant, Wa Wu people from town, Suining County, the patient did manual work about half a year in Zhejiang factory May calendar year 2001, the unknown cause morbidity, from the beginning of both hands refer to, knee joint, toe joint congestion and swelling pain, the back is gone back to this county institute of traditional Chinese medicine and is diagnosed as rheumatoid arthritis, is in hospital through combination therapy of Chinese and western, once obeys aspirin, heavy when light when prednisone, Heiguteng exract capsule etc., and relate to cervical vertebra.On January 11st, 2002 is again through 169 central hospitals treatments, after not only on August 19th, 2002 but also through PLA's 181 HCs treatment, combination therapy of Chinese and western is alleviated to some extent, but the state of an illness increases the weight of October again, in the transfusion of local hospital, because hormonosis causes the wide arthralgia in the left and right sides, stiff walking is difficult, then comes me to go to a doctor on February 14th, 2002, and disease is seen: cervical vertebra is stiff, difficulty in opening mouth, both shoulders, elbow, wrist, finger, two knee joints, ankle, the sole of the foot, toe joint swelling heating pain, local ecchymosis, subcutaneous nodule, it is difficult to take action, joint stuffiness, and the complexion Guang is white, lassitude, aversion to cold and cold limbs, menoxenia, the few color of amount secretly has piece, repeatedly induced labor history was once arranged, constipation, little Huang of urinating, xerostomia is sticky, the white BOHUANG of tongue, slippery and rapid pulse, experimental check: the rheumatoid factor positive, erythrocyte sedimentation rate 80mm/h, anti-" 0 " 600n, through the fine and soft ball of clothes kylin breast of the present invention, every day three times, each 10 grams.One the course of treatment freedom of movement, treat and be almost recovered two courses of treatment, consolidate two courses of treatment, follow up a case by regular visits to not recurrence in 2 years.
Following embodiment is used to further specify the present invention:
Embodiment 1:
Semen Strychni (processed) 50g Scorpio 70g Rhizoma Atractylodis Macrocephalae 70g Radix Saposhnikoviae 70g
Rhizoma Anemarrhenae 40g Borneolum Syntheticum 4g Os pardi 100g Squama Manis 70g
Poria 70g Sinomenium acutum 100g Formica fusca 130g Agkistrodon 15g
Sanguis Draxonis 90g Radix Rehmanniae Preparata 110g Spina Gleditsiae 40g Cornu rhinocerotis 15g
Radix Tripterygii Wilfordii tablet 20g Radix Notoginseng 70g Radix Ginseng 50g Radix Rehmanniae 110g
Radix Aconiti Preparata 70g Herba Asari 40g Hirudo 70g Radix Astragali 110g
Cornu Cervi Pantotrichum 25g Herba Ephedrae 30g Ganoderma 40g Scolopendra 30g
Radix Angelicae Sinensis 70g Hippocampus 45g Olibanum 40g Flos Lonicerae 60g
Catharsii molossi 70g Radix Paeoniae Alba 70g Solenognathus 45g Myrrha 40g
Radix Glycyrrhizae 35g ground beetle 70g Rhizoma Chuanxiong 70g Colla Plastri Testudinis 70g
Cortex Phellodendri 40g Moschus 2g
With Semen Strychni (processed) fried or stir-baking with sand to the outside pale brown color, 2 times of Semen Strychni are arranged for good during expansion, it is standby to grind superfine mistake 100 mesh sieves; Sinomenium acutum must be fried with 320g rice wine; When treating that pot is put into pure rice wine when red, method is good, fries and so fry 7-8 time altogether repeatedly after doing that drying is beaten superfine powder, and to cross 100 mesh sieves standby with explosive sound; The Os pardi stir-baking with sand is to the buff shakeout, pours the Chinese liquor stain while hot into and quenches, and take out after the roasting heat again stain and quench, 2-4 time repeatedly, extremely crisp, cool, it is standby to break into fine powder; Catharsii molossi, ground beetle baking grind to the powder standby; Scorpio, Scolopendra spray Chinese liquor baking drying, it is standby to grind to the powder; Hirudo cutting sheet is fried to little heaving with Talcum, and it is standby that sieve goes Pulvis Talci to grind to the powder; Squama Manis stir-baking with sand system is heaved when being golden yellow, takes out, and the sieve sand that deoils immediately with in the Squama Manis impouring 35g vinegar basin, stirs and slightly soaks, and pulls out to dry with water rinse and beats superfine end to cross 100 mesh sieves standby; Cornu Cervi Pantotrichum, Agkistrodon, Hippocampus, Solenognathus use yellow wine moistening, and little to be baked to the loose yellow that is, it is standby that the mill impalpable powder is crossed 100 mesh sieves; The Radix Rehmanniae, Radix Rehmanniae Preparata shave, oven dry grinds to the powder; Radix Notoginseng, the Radix Astragali, Radix Ginseng section are ground into powder, and Radix Saposhnikoviae, Spina Gleditsiae, Radix Aconiti Preparata grind to the powder standby by traditional method process of preparing Chinese medicine detoxification, and Herba Ephedrae, Cortex Phellodendri, Herba Asari decontamination grind to the powder standby; Turn to saline with 12g salt, the Rhizoma Anemarrhenae is got final product with dried the grinding to the powder of slow fire stir-fry with the saline profit is rare; Flos Lonicerae, Radix Glycyrrhizae are dried 100 mesh sieves that ground to the powder, and Ganoderma shave oven dry porphyrize is standby; Olibanum, Myrrha use the slow fire parch molten slightly respectively, and spray vinegar continues to stir to coke black, take out and cool 100 mesh sieves that ground to the powder; The Radix Tripterygii Wilfordii tablet porphyrize uses; The Rhizoma Atractylodis Macrocephalae, Borneolum Syntheticum, Poria, Formica fusca, Sanguis Draxonis, Spina Gleditsiae, Cornu rhinocerotis, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Rhizoma Chuanxiong, Colla Plastri Testudinis, Moschus are ground into fine powder to be mixed with above-mentioned gained material and stirs, under 100 degrees centigrade, sterilize, handle after 20-30 minute, add conventional adjuvant or pill is made in the agent of figuration material.Each 8 grams of the lighter for oral administration, each 10 grams of heavy person, every day three times, warm water delivery service after meal, one month is a course of treatment.
Embodiment 2:
Semen Strychni (processed) 45g Scorpio 75g Rhizoma Atractylodis Macrocephalae 65g Radix Saposhnikoviae 75g
Rhizoma Anemarrhenae 35g Borneolum Syntheticum 4.5g Os pardi 90g Squama Manis 75g
Poria 65g Sinomenium acutum 110g Formica fusca 110g Agkistrodon 18g
Sanguis Draxonis 85g Radix Rehmanniae Preparata 115g Spina Gleditsiae 35g Cornu rhinocerotis 18g
Radix Tripterygii Wilfordii tablet 15g Radix Notoginseng 75g Radix Ginseng 45g Radix Rehmanniae 115g
Radix Aconiti Preparata 65g Herba Asari 45g Hirudo 65g Radix Astragali 115g
Cornu Cervi Pantotrichum 22g Herba Ephedrae 35g Ganoderma 35g Scolopendra 35g
Radix Angelicae Sinensis 65g Hippocampus 55g Olibanum 35g Flos Lonicerae 65g
Catharsii molossi 65g Radix Paeoniae Alba 75g Solenognathus 35g Myrrha 45g
Radix Glycyrrhizae 25g ground beetle 75g Rhizoma Chuanxiong 65g Colla Plastri Testudinis 75g
Cortex Phellodendri 35g Moschus 2.5g
Said medicine technology is routinely made tablet.
Embodiment 3:
Semen Strychni (processed) 55g Scorpio 65g Rhizoma Atractylodis Macrocephalae 75g Radix Saposhnikoviae 65g
Rhizoma Anemarrhenae 45g Borneolum Syntheticum 3.5g Os pardi 110g Squama Manis 65g
Poria 75g Sinomenium acutum 90g Formica fusca 150g Agkistrodon 12g
Sanguis Draxonis 95g Radix Rehmanniae Preparata 105g Spina Gleditsiae 45g Cornu rhinocerotis 12g
Radix Tripterygii Wilfordii tablet 25g Radix Notoginseng 65g Radix Ginseng 55g Radix Rehmanniae 105g
Radix Aconiti Preparata 75g Herba Asari 35g Hirudo 75g Radix Astragali 105g
Cornu Cervi Pantotrichum 28g Herba Ephedrae 25g Ganoderma 45g Scolopendra 25g
Radix Angelicae Sinensis 75g hippocampus 3 5g Olibanum 45g Flos Lonicerae 55g
Catharsii molossi 75g Radix Paeoniae Alba 65g Solenognathus 55g Myrrha 35g
Radix Glycyrrhizae 45g ground beetle 65g Rhizoma Chuanxiong 75g Colla Plastri Testudinis 65g
Cortex Phellodendri 45g Moschus 1.5g
Said medicine technology is routinely made capsule.
Claims (10)
1, a kind of pharmaceutical composition for the treatment of rheumatism atrophic arthritis is characterized in that said composition is to be made by following crude drug:
Semen Strychni (processed) 40-60 weight portion Scorpio 60-80 weight portion Rhizoma Atractylodis Macrocephalae 60-80 weight portion
Radix Saposhnikoviae 60-80 weight portion Rhizoma Anemarrhenae 30-50 weight portion Borneolum Syntheticum 3-5 weight portion
Os pardi 80-120 weight portion Squama Manis 60-80 weight portion Poria 60-80 weight portion
Sinomenium acutum 80-120 weight portion Formica fusca 100-160 weight portion Agkistrodon 10-20 weight portion
Sanguis Draxonis 80-100 weight portion Radix Rehmanniae Preparata 100-120 weight portion Spina Gleditsiae 30-50 weight portion
Cornu rhinocerotis 10-20 weight portion Radix Tripterygii Wilfordii tablet 10-30 weight portion Radix Notoginseng 60-80 weight portion
Radix Ginseng 40-60 weight portion Radix Rehmanniae 100-120 weight portion Radix Aconiti Preparata 60-80 weight portion
Herba Asari 30-50 weight portion Hirudo 60-80 weight portion Radix Astragali 100-120 weight portion
Cornu Cervi Pantotrichum 20-30 weight portion Herba Ephedrae 20-40 weight portion Ganoderma 30-50 weight portion
Scolopendra 20-40 weight portion Radix Angelicae Sinensis 60-80 weight portion hippocampus 3 0-60 weight portion
Olibanum 30-50 weight portion Flos Lonicerae 50-70 weight portion Catharsii molossi 60-80 weight portion
Radix Paeoniae Alba 60-80 weight portion Solenognathus 30-60 weight portion Myrrha 30-50 weight portion
Radix Glycyrrhizae 20-50 weight portion ground beetle 60-80 weight portion Rhizoma Chuanxiong 60-80 weight portion
Colla Plastri Testudinis 60-80 weight portion Cortex Phellodendri 30-50 weight portion Moschus 1-3 weight portion.
2, pharmaceutical composition according to claim 1 is characterized in that said composition is to be made by following crude drug:
The Semen Strychni (processed) 50 weight portion Scorpio 70 weight portion Rhizoma Atractylodis Macrocephalaes 70 weight portions
The Radix Saposhnikoviae 70 weight portion Rhizoma Anemarrhenaes 40 weight portion Borneolum Syntheticums 4 weight portions
Os pardi 100 weight portion Squama Maniss 70 weight portion Poria 70 weight portions
Sinomenium acutum 100 weight portion Formica fuscas 130 weight portion Agkistrodons 15 weight portions
Sanguis Draxonis 90 weight portion Radix Rehmanniaes Preparata 110 weight portion Spina Gleditsiae 40 weight portions
Cornu rhinocerotis 15 weight portion Radix Tripterygii Wilfordii tabletes 20 weight portion Radix Notoginseng 70 weight portions
The Radix Ginseng 50 weight portion Radix Rehmanniae 110 weight portion Radix Aconiti Preparatas 70 weight portions
The Herba Asari 40 weight portion Hirudos 70 weight portion Radixs Astragali 110 weight portions
Cornu Cervi Pantotrichum 25 weight portion Herba Ephedraes 30 weight portion Ganoderma 40 weight portions
Scolopendra 30 weight portion Radix Angelicae Sinensis 70 weight portion Hippocampus 45 weight portions
Olibanum 40 weight portion Flos Loniceraes 60 weight portion Catharsii molossis 70 weight portions
The Radix Paeoniae Alba 70 weight portion Solenognathus 45 weight portion Myrrhas 40 weight portions
Radix Glycyrrhizae 35 weight portion ground beetles 70 weight portion Rhizoma Chuanxiongs 70 weight portions
Colla Plastri Testudinis 70 weight portion Cortex Phellodendris 40 weight portion Moschus 2 weight portions.
3, pharmaceutical composition according to claim 1 is characterized in that said composition is to be made by following crude drug:
The Semen Strychni (processed) 45 weight portion Scorpio 75 weight portion Rhizoma Atractylodis Macrocephalaes 65 weight portions
The Radix Saposhnikoviae 75 weight portion Rhizoma Anemarrhenaes 35 weight portion Borneolum Syntheticums 4.5 weight portions
Os pardi 90 weight portion Squama Maniss 75 weight portion Poria 65 weight portions
Sinomenium acutum 110 weight portion Formica fuscas 110 weight portion Agkistrodons 18 weight portions
Sanguis Draxonis 85 weight portion Radix Rehmanniaes Preparata 115 weight portion Spina Gleditsiae 35 weight portions
Cornu rhinocerotis 18 weight portion Radix Tripterygii Wilfordii tabletes 15 weight portion Radix Notoginseng 75 weight portions
The Radix Ginseng 45 weight portion Radix Rehmanniae 115 weight portion Radix Aconiti Preparatas 65 weight portions
The Herba Asari 45 weight portion Hirudos 65 weight portion Radixs Astragali 115 weight portions
Cornu Cervi Pantotrichum 22 weight portion Herba Ephedraes 35 weight portion Ganoderma 35 weight portions
Scolopendra 35 weight portion Radix Angelicae Sinensis 65 weight portion Hippocampus 55 weight portions
Olibanum 35 weight portion Flos Loniceraes 65 weight portion Catharsii molossis 65 weight portions
The Radix Paeoniae Alba 75 weight portion Solenognathus 35 weight portion Myrrhas 45 weight portions
Radix Glycyrrhizae 25 weight portion ground beetles 75 weight portion Rhizoma Chuanxiongs 65 weight portions
Colla Plastri Testudinis 75 weight portion Cortex Phellodendris 35 weight portion Moschus 2.5 weight portions.
4, pharmaceutical composition according to claim 1 is characterized in that said composition is to be made by following crude drug:
The Semen Strychni (processed) 55 weight portion Scorpio 65 weight portion Rhizoma Atractylodis Macrocephalaes 75 weight portions
The Radix Saposhnikoviae 65 weight portion Rhizoma Anemarrhenaes 45 weight portion Borneolum Syntheticums 3.5 weight portions
Os pardi 110 weight portion Squama Maniss 65 weight portion Poria 75 weight portions
Sinomenium acutum 90 weight portion Formica fuscas 150 weight portion Agkistrodons 12 weight portions
Sanguis Draxonis 95 weight portion Radix Rehmanniaes Preparata 105 weight portion Spina Gleditsiae 45 weight portions
Cornu rhinocerotis 12 weight portion Radix Tripterygii Wilfordii tabletes 25 weight portion Radix Notoginseng 65 weight portions
The Radix Ginseng 55 weight portion Radix Rehmanniae 105 weight portion Radix Aconiti Preparatas 75 weight portions
The Herba Asari 35 weight portion Hirudos 75 weight portion Radixs Astragali 105 weight portions
Cornu Cervi Pantotrichum 28 weight portion Herba Ephedraes 25 weight portion Ganoderma 45 weight portions
Scolopendra 25 weight portion Radix Angelicae Sinensis 75 weight portion hippocampus 3s 5 weight portions
Olibanum 45 weight portion Flos Loniceraes 55 weight portion Catharsii molossis 75 weight portions
The Radix Paeoniae Alba 65 weight portion Solenognathus 55 weight portion Myrrhas 35 weight portions
Radix Glycyrrhizae 45 weight portion ground beetles 65 weight portion Rhizoma Chuanxiongs 75 weight portions
Colla Plastri Testudinis 65 weight portion Cortex Phellodendris 45 weight portion Moschus 1.5 weight portions.
5,, it is characterized in that described Os pardi substitutes with zokor bone or Bailey Myospalax Born according to claim 1,2,3 or 4 described pharmaceutical compositions; Described Spina Gleditsiae substitutes with Bombyx Batryticatus; Described Cornu rhinocerotis substitutes with Cornu Saigae Tataricae or Cornu Bubali; Described Radix Tripterygii Wilfordii tablet substitutes with Radix Tripterygii Wilfordii extractum; Described Agkistrodon is a shallow bid footpath Agkistrodon.
6,, it is characterized in that the conventional adjuvant that said composition adds pharmaceutically makes the dosage form of clinical acceptance: be tablet, suppository, capsule, granule, spray, ointment, emplastrum or ointment according to claim 1,2,3 or 4 described pharmaceutical compositions.
7, according to claim 1,2,3 or 4 described preparation of drug combination methods, it is characterized in that this method is: with Semen Strychni (processed) fried or stir-baking with sand to the outside pale brown color, 2 times of Semen Strychni are arranged for good during expansion, it is standby to grind superfine mistake 100 mesh sieves; Sinomenium acutum must be fried with 250-400 weight portion rice wine; When treating that pot is put into pure rice wine when red, method is good, fries and so fry 5-9 time altogether repeatedly after doing that drying is beaten superfine powder, and to cross 100 mesh sieves standby with explosive sound; The Os pardi stir-baking with sand is to the buff shakeout, pours the Chinese liquor stain while hot into and quenches, and take out after the roasting heat again stain and quench, 2-4 time repeatedly, extremely crisp, cool, it is standby to break into fine powder; Catharsii molossi, ground beetle baking grind to the powder standby; Scorpio, Scolopendra spray Chinese liquor baking drying, it is standby to grind to the powder; Hirudo cutting sheet is fried to little heaving with Talcum, and it is standby that sieve goes Pulvis Talci to grind to the powder; Squama Manis stir-baking with sand system is heaved when being golden yellow, takes out, and the sieve sand that deoils immediately with in the Squama Manis impouring 30-40 weight portion vinegar basin, stirs and slightly soaks, and pulls out to dry with water rinse and beats superfine end to cross 100 mesh sieves standby; Cornu Cervi Pantotrichum, Agkistrodon, Hippocampus, Solenognathus use yellow wine moistening, and little to be baked to the loose yellow that is, it is standby that the mill impalpable powder is crossed 100 mesh sieves; The Radix Rehmanniae, Radix Rehmanniae Preparata shave, oven dry grinds to the powder; Radix Notoginseng, the Radix Astragali, Radix Ginseng section are ground into powder, and Radix Saposhnikoviae, Spina Gleditsiae, Radix Aconiti Preparata grind to the powder standby by traditional method process of preparing Chinese medicine detoxification, and Herba Ephedrae, Cortex Phellodendri, Herba Asari decontamination grind to the powder standby; Turn to saline with 9-15 weight portion salt, the Rhizoma Anemarrhenae is got final product with dried the grinding to the powder of slow fire stir-fry with the saline profit is rare; Flos Lonicerae, Radix Glycyrrhizae are dried 100 mesh sieves that ground to the powder, and Ganoderma shave oven dry porphyrize is standby; Olibanum, Myrrha use the slow fire parch molten slightly respectively, and spray vinegar continues to stir to coke black, take out and cool 100 mesh sieves that ground to the powder; The Radix Tripterygii Wilfordii tablet porphyrize uses; The Rhizoma Atractylodis Macrocephalae, Borneolum Syntheticum, Poria, Formica fusca, Sanguis Draxonis, Spina Gleditsiae, Cornu rhinocerotis, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Rhizoma Chuanxiong, Colla Plastri Testudinis, Moschus are ground into fine powder to be mixed with above-mentioned gained material and stirs, under 100 degrees centigrade, sterilize, handle after 20-30 minute, add conventional adjuvant or tablet, the watered pill, honeyed pill, capsule or granule dosage form are made in the agent of figuration material.
8, preparation of drug combination method according to claim 7 is characterized in that this preparation method is: with Semen Strychni (processed) fried or stir-baking with sand to the outside pale brown color, 2 times of Semen Strychni are arranged for good during expansion, it is standby to grind superfine mistake 100 mesh sieves; Sinomenium acutum must be fried with 320 weight portion rice wine; When treating that pot is put into pure rice wine when red, method is good, fries and so fry 7-8 time altogether repeatedly after doing that drying is beaten superfine powder, and to cross 100 mesh sieves standby with explosive sound; The Os pardi stir-baking with sand is to the buff shakeout, pours the Chinese liquor stain while hot into and quenches, and take out after the roasting heat again stain and quench, 2-4 time repeatedly, extremely crisp, cool, it is standby to break into fine powder; Catharsii molossi, ground beetle baking grind to the powder standby; Scorpio, Scolopendra spray Chinese liquor baking drying, it is standby to grind to the powder; Hirudo cutting sheet is fried to little heaving with Talcum, and it is standby that sieve goes Pulvis Talci to grind to the powder; Squama Manis stir-baking with sand system is heaved when being golden yellow, takes out, and the sieve sand that deoils immediately with in the Squama Manis impouring 35 weight portion vinegar basins, stirs and slightly soaks, and pulls out to dry with water rinse and beats superfine end to cross 100 mesh sieves standby; Cornu Cervi Pantotrichum, Agkistrodon, Hippocampus, Solenognathus use yellow wine moistening, and little to be baked to the loose yellow that is, it is standby that the mill impalpable powder is crossed 100 mesh sieves; The Radix Rehmanniae, Radix Rehmanniae Preparata shave, oven dry grinds to the powder; Radix Notoginseng, the Radix Astragali, Radix Ginseng section are ground into powder, and Radix Saposhnikoviae, Spina Gleditsiae, Radix Aconiti Preparata grind to the powder standby by traditional method process of preparing Chinese medicine detoxification, and Herba Ephedrae, Cortex Phellodendri, Herba Asari decontamination grind to the powder standby; Turn to saline with 12 weight portion salt, the Rhizoma Anemarrhenae is got final product with dried the grinding to the powder of slow fire stir-fry with the saline profit is rare; Flos Lonicerae, Radix Glycyrrhizae are dried 100 mesh sieves that ground to the powder, and Ganoderma shave oven dry porphyrize is standby; Olibanum, Myrrha use the slow fire parch molten slightly respectively, and spray vinegar continues to stir to coke black, take out and cool 100 mesh sieves that ground to the powder; The Radix Tripterygii Wilfordii tablet porphyrize uses; The Rhizoma Atractylodis Macrocephalae, Borneolum Syntheticum, Poria, Formica fusca, Sanguis Draxonis, Spina Gleditsiae, Cornu rhinocerotis, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Rhizoma Chuanxiong, Colla Plastri Testudinis, Moschus are ground into fine powder to be mixed with above-mentioned gained material and stirs, under 100 degrees centigrade, sterilize, handle after 20-30 minute, add conventional adjuvant or tablet, the watered pill, honeyed pill, capsule or granule dosage form are made in the agent of figuration material.
9, as the application of pharmaceutical composition as described in the claim 1,2,3 or 4 in the medicine of preparation treatment rheumatism atrophic arthritis.
10, as the application of pharmaceutical composition as described in the claim 5 in the medicine of preparation treatment rheumatism atrophic arthritis.
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| CNB2005100722865A CN100368001C (en) | 2005-05-27 | 2005-05-27 | Medicine composition for treating rheumatic arthritis and rheumatoid arthritis, and its prepn. method |
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| CN101152242B (en) * | 2007-09-30 | 2010-10-20 | 毛顺卿 | Medicament for treating Chinese medical stubborn paralysis |
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| CN101337002B (en) * | 2008-08-08 | 2012-06-20 | 韩敏 | Traditional Chinese medicine capsule for treating rheumatism and nervous system |
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| CN1168479C (en) * | 2002-04-26 | 2004-09-29 | 李庆华 | Ointment for curing rheumatism and osteoarthropathy |
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| CN101632764B (en) * | 2009-08-26 | 2011-03-30 | 王天旺 | Plaster for treating burns |
| CN103610982A (en) * | 2013-02-19 | 2014-03-05 | 武瑞美 | Medicine for treating rheumatic arthritis |
| CN103610982B (en) * | 2013-02-19 | 2015-07-29 | 武瑞美 | A kind of medicine for the treatment of rheumatic arthritis |
| CN104127754A (en) * | 2013-09-11 | 2014-11-05 | 金坛韩氏中医关节病专科医院 | Traditional Chinese medicine composition for treating rheumatism and preparation method thereof |
| CN103550471A (en) * | 2013-10-25 | 2014-02-05 | 王增智 | Traditional Chinese medicine (TCM) composition for treating Bi pain |
| CN105012499A (en) * | 2015-07-03 | 2015-11-04 | 北京昶沣科技有限公司 | Traditional Chinese medicine ointment used for treating rheumatoid disease and preparation method thereof |
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