CN1726395A - Specific markers for pancreatic cancer - Google Patents

Abstract

The present invention provides polypeptides which are up- or down-regulated in pancreatic cancer and which can be used as markers for diagnosis of pancreatic cancer. The invention also provides an in vitro method for the diagnosis of pancreatic cancer and/or the susceptibility to pancreatic cancer comprising the steps of a) obtaining a biological sample; and b) detecting and/or measuring the increase of one or more polypeptides as disclosed herein. Furthermore, screening methods relating to inhibitors and antagonists of the specific polypeptides disclosed herein are provided.

Description

Specific markers for pancreatic cancer

technical field

The present invention relates to a marker for diagnosing pancreatic cancer (pancreatic carcinoma, PC), the marker comprising at least one polypeptide identified by proteomics as having increased expression in pancreatic cancer, and the present invention also relates to an in vitro diagnosis of pancreatic cancer and/or A method for susceptibility to pancreatic cancer, the method comprising the following steps: a) obtaining a biological sample; b) detecting and/or measuring the specific marker disclosed in the present invention. In addition, the present invention also provides a screening method for the antagonist of the disclosed specific marker for the treatment of pancreatic cancer.

Background technique

Pancreatic cancer is a common cause of death in the West. It is one of the most harmful malignant tumors, with a general 5-year survival rate of 0.4%. In many pancreatic cancer patients, it is difficult to achieve accurate preoperative diagnosis with conventional imaging examinations. Most patients are diagnosed at an advanced stage with local spread or metastasis. Usually only 20% of patients are selected for resection, making surgical treatment possible. The reason for this late detection is the lack of diagnostic methods for early detection of the disease. In addition to the lack of diagnostic methods, another reason for the high mortality rate of pancreatic cancer patients is the lack of effective treatment methods. Therefore, challenges for the early diagnosis of pancreatic tumors and for the development of agents (biotherapeutic targets) for the treatment of pancreatic cancer are of great importance.

Contents of the invention

The present invention identifies the polypeptide with altered expression in pancreatic cancer by applying new proteomics technology, which can be used as a marker for early diagnosis of pancreatic cancer. By using proteomic techniques, it was found that a specific set of polypeptides were differentially expressed in pancreatic cancer tissue obtained from individuals with HR/03.11.2003 compared to healthy pancreatic tissue. The indicated differentially expressed polypeptides are listed in the appended Tables 2 and 3. The polypeptides listed in Table 3 were previously shown to be increased at the transcriptional level in pancreatic cancer (Iacobuzio-Donahue et al., (2002), Am. J. Pathol. 160, 1239-1249). However, it is well known that regulation at the transcriptional level does not necessarily imply a similar change in the expression of the corresponding gene at the translational level. Therefore, only if the polypeptides listed in Table 3 are proved to be highly expressed in pancreatic cancer, it is possible to use them to perform polypeptide-based diagnostic assays for the detection of pancreatic cancer.

According to the polypeptides listed in Table 2 and Table 3, the present invention provides a marker for diagnosing pancreatic cancer, which comprises at least one polypeptide (Seq ID No.1) selected from those listed in Table 2 and/or Table 3 -24, and 26-49; and/or Seq ID No.25 and 50-55). Accordingly, the term "marker" as used herein refers to one or more polypeptides that are differentially expressed in cancer and can be used alone, or as a mixture of polypeptides known to be differentially expressed in pancreatic cancer, for the diagnosis of pancreatic cancer Or susceptibility to pancreatic cancer. Four grades preferably refer to polypeptides selected from Seq ID No.2-10, 12-15, 17, 19, 20, 23, 24, 27, 28, 31-40, 42-45, 47 and 48; and/or SeqID Nos. 25 and 50-54. Tertiary preferably refers to the polypeptide selected from Seq ID No.3,4,6,9,14,15,27,31-35,37,39,40; and/or Seq ID No.50-52. Secondary preference refers to polypeptides selected from Seq ID Nos. 4, 6, 9, 14, 15, 31, 33-35, and/or Seq ID Nos. 51 and 52. A first level preferably refers to a polypeptide selected from Seq ID No. 4, 6, 14, 15 and 31; and/or Seq ID No. 52.

The term "polypeptide" as used herein refers to a polymer of amino acids, not to the indicated length. Thus, peptides, oligopeptides and proteins are included within the definition of polypeptide.

Preferably, the marker of the present invention is or comprises at least one marker selected from the polypeptides listed in Table 2.

In addition, polypeptides selected from those listed in Tables 2 and/or 3 are used as markers or part of markers for the diagnosis of pancreatic cancer and/or susceptibility to pancreatic cancer. Four grades preferably refer to the polypeptide selected from Seq ID No.2-10, 12-15, 17, 19, 20, 23, 24, 27, 28, 31-40, 42-45, 47 and 48 of Table 2, and/or Seq ID Nos. 25 and 50-54 of Table 3. It can be seen from Table 2 and Table 3 that these polypeptides are differentially expressed by at least 2 times. Tertiary preferably refers to the polypeptide selected from Seq ID No.3,4,6,9,14,15,27,31-35,37,39,40 of Table 2, and/or Seq ID No. of Table 3. 50-52. As can be seen from Tables 2 and 3, these polypeptides were induced at least 3-fold. Secondary preferably refers to the polypeptide selected from SeqID No.4, 6, 9, 14, 15, 31, 33-35 of Table 2, and/or Seq ID No.51-52 of Table 3. As can be seen from Table 2 and Table 3, these polypeptides are induced at least 4 times, and the first-level preferred polypeptide is selected from Seq ID No.4, 6, 14, 15 and 31 of Table 2, and/or Seq ID No. of Table 3 .52. As shown in Tables 2 and 3, these polypeptides were induced 5-fold.

The present invention relates to a marker for diagnosing pancreatic cancer, the marker comprising at least one polypeptide selected from Table 6. Preferably reference to at least one polypeptide does not additionally include Seq ID No. 25 and 50-55.

In a preferred embodiment, the markers described above additionally comprise at least one polypeptide listed in Table 5.

Several groups of peptides have been identified as markers for pancreatic cancer:

enzyme

One of the enzymes that caught our attention was glutamine gamma-glutamyltransferase/tissue transglutaminase (TGLC, Seq ID No. 54). It is a member of the transglutaminase family, which catalyzes Ca ²⁺ -dependent reactions leading to post-translational modifications (cross-linking with polyamines) of proteins at the level of glutamine and lysine residues (Greenberg, CS, Birckbichler, PJ, and Rice, RH Transglutaminases: multifunctional cross-linking enzymes that stabilize tissues. FASEBJ., 5:3071-3077, 1991). The multiple effects of this protein have been described, including apoptosis, adhesion and differentiation (Amendola, A., Fesus, L., Piacentini, M., and Szondy, Z. "Tissue" transglutaminase in AIDS.J Immunol. Methods, 265:145-159, 2002). The role of TGLC in apoptosis is somewhat controversial. Although several lines of evidence suggest that TGLC is a pro-apoptotic protein (Melino, G., et al., Mol. Cell Biol., 14:6584-6596, 1994), Jason et al. found that TGLC acts in an anti-apoptotic manner function (Boehm, JE et al. J. Biol. Chem., 277:20127-20130, 2002). Many substrates of TGLC are major components of the extracellular matrix (ECM), such as fibronectin, osteonectin, collagen, which makes TGLC an important enzyme in the formation of ECM (Raghunath, M. et al., J.Clin Invest, 98:1174-1184, 1996., Nemes, Z., Jr. et al., J.Biol.Chem., 272:20577-20583, 1997), abnormal ECM formation is related to many pathological conditions, such as fibrous and may play a role in the proliferation of fibrous tissue observed in PC, Haroon et al. describe that the ability of TGLC to promote EMC is an important part of the host's response mechanism against tumor growth (Haroon, ZA et al., Lab Invest, 79:1679 -1686, 1999). Interestingly, loss of TGLC is a biomarker for prostate adenocarcinoma (Birckbichler, PJ, et al., Cancer, 89:412-423, 2000), raising the question whether the measured TGLC is caused by tumorigenic produced by ductal and/or stromal cells. Measurement of mRNA levels in PC, normal tissues and PC cell lines showed that TGLC was highly expressed in both cell types (Iacobuzio-Donahue, CA et al., Am. J. Pathol., 160:1239-1249, 2002) , therefore, a preferred solution of the present invention is to include the marker of Seq ID No.54.

cytoskeletal protein

Several cytoskeletal proteins were detected in PC with higher expression than its surrounding normal pancreatic tissue, one of which was gelsolin, which is a Ca2 ⁺ and PIP2 (polyphosphoinositide 4,5-bisphosphate) regulated capping protein, which is a multifunctional actin-regulated protein and plays a role in actin remodeling, migration, signal transduction, apoptosis and carcinogenesis (Maruta, HG proteins cytoskeleton and cancer. Austin, Tex.: RG Landes, 1998). In studies of several cancers, expression of gelsolin has been described as decreased in the development of carcinomas (breast, colon, stomach, bladder, prostate and lung) (Asch, HL et al., Cancer Res., 56: 4841-4845, 1996; Dosaka-Akita, H. et al., Cancer Res., 58:322-327, 1998, Prasad, SC et al., Electrophoresis, 18:629-637, 1997). Another example of a cytoskeletal protein with increased expression is fascin, (Seq ID No. 58), which is an actin-binding protein that plays a role in cell-matrix adhesion, cell interaction, and migration. Fascin has been reported to be highly expressed in several cancers, such as breast, colon and oral cancers (29).

The present invention is also characterized by fascin 2 as an expression-increasing polypeptide in pancreatic cancer (Seq ID No.56). Therefore, a preferred embodiment of the present invention is a marker comprising Seq ID No.3. In another preferred embodiment, the marker comprises Seq ID No.56.

In our study, cytokeratin 7 (Seq ID NO.52) and cytokeratin 19 (Seq ID NO.33) showed higher expression in PC. These two proteins have been described in other cancers and are associated with metastasis (Moll, R., Int. J. Biol. Markers, 9:63-69, 1994).

High protein levels of actinin 4 (Seq ID No. 5) were detected in PC. Some researchers believe that this protein is related to cell migration and cancer invasiveness (Honda, K., Yamada, T., Endo, R., Ino, Y., Gotoh, M., Tsuda, H., Yamada, Y. , Chiba, H., and Hirohashi, S.J. Cell Biol., 140:1383-1393, 1998.). In conclusion, the high expression of cytoskeletal proteins may be an important factor for the high invasiveness of PC and the possibility of metastasis. Therefore, a preferred embodiment of the present invention is a marker comprising Seq ID No.52. In another preferred embodiment, the marker comprises Seq ID No.5.

transfer

Carcinoma of the exocrine pancreas is characterized by extensive local invasion with early lymphoid and hematologic metastases. Metastasis of PC has been found in bones, eyes, bladder, etc. The extent of angiogenesis depends on the balance of pro-angiogenic and anti-angiogenic factors released by cancer and host cells. Currently, intratumoral microvessel density (IMD) measured by immunocytochemistry appears to be the most reliable parameter for judging angiogenic activity. Among various cancers, patients with high IMD have a low survival rate (Fujioka, S. et al., Cancer, 92: 1788-1797, 2001). Thymidine phosphorylase (TYPH or TP.Seq ID No.31), which is equivalent to platelet-derived growth factor, is strongly expressed in PC and stimulates endothelial cell migration through 2-deoxy-D-ribose, a TP degradation product of thymidine. Angiogenesis, thereby indirectly inducing angiogenesis (Haraguchi, M. et al., Nature, 368:198, 1994.). Shuichi Fujioka et al. found that IMD and TP status in PC were independent predictors for general and recurrence-free PC survivors (Fujioka, S., et al., Cancer, 92:1788-1797, 2001). Another protein that may be involved in the formation of metastases is osteoblast-specific factor 2 (Seq ID No.53). The level of this protein detected in PC is higher than that in its surrounding tissues. Osteoadhesin. Breast cancer often metastasizes to bone (Guise, T.A. Cancer, 88:2892-2898, 2000). Although the role of this protein in PC is not well defined, our findings suggest a similar role for osteoblasts in PC. Therefore, a preferred embodiment of the present invention is a marker comprising Seq ID No.31. In another preferred embodiment, the marker comprises Seq ID No. 53.

small molecule GTP binding protein

The expression of four small molecule GTP-binding proteins and interacting proteins in PC was higher than that in normal pancreas. These proteins include RAN (Seq ID No.27), GBLP (similar to guanine nucleotide binding protein β subunit protein RACK1, Seq ID No.47), GDIR (Rho GDP dissociation inhibitor 1, Seq ID No.55 ), and IQG1 or IQGAP1 (similar to Ras GTPase activating protein, Seq ID No.25). Small-molecule GTP-binding proteins form a superfamily, which can be structurally divided into at least five families: Ras, Rho, Rab, Sarl/Arf, and Ran, and are involved in the regulation of gene expression, regeneration of cytoskeletal tissues, and nuclear Mass transport (Takai, Y. et al., Physiol Rev., 81:153-208, 2001). RAN is known to enhance androgen receptor-mediated transactivation and has been shown to be highly expressed in prostate cancer (Sampson, E.R. et al., J. Biol. Regul. Homeost. Agents, 15:123-129, 2001). The expression of RAN is upregulated in 81% of prostate tumor cases, and this upregulation may contribute to the excessive proliferation of prostate tumor cells (Li, P. et al., Am J Pathol., 161:1467-1474, 2002). GBLP is an anchor protein for activated protein kinase Cβ as well as various other proteins. Protein kinase C plays an important role in angiogenesis and cancer growth. Bern et al. found that GBLP expression was increased during angiogenesis in vitro and was also associated with non-endothelial cells in angiogenically active tissues (Berns, H. et al., FASEB J., 14:2549-2558, 2000). In addition, GBLP mRNA expression was detected in human colon cancer epithelial cells and in proliferating epithelial cells of normal colon tissue.

Therefore, there may be a link between high GBLP expression and tumor growth. GDIR (Rho GDP dissociation inhibitor) has been found to have increased expression in drug-resistant fibrosarcoma cell lines (Sinha, P. et al., Electrophoresis, 20:2961-2969, 1999) and may block Ras and c-jun Kinase-mediated apoptotic signaling pathway leading to increased resistance to environmental stress. IQG1 (Ras GTPase-like activator protein) is a ubiquitously expressed 190Kda Cdc42-, Racl- and calmodulin-binding protein that interacts with F-actin in vivo and binds to F-actin microfilaments In Vitro Outlinking. IQG1 negatively regulates cell-cell adhesion dominated by Ecc (E-cadherin/calmodulin complex) by dissociating α-catenin. Increased expression of IQGAP1 is associated with a malignant phenotype of gastric cancer (Sugimoto, N. et al., J. Hum. Genet., 46:21-25, 2001).

Through immunohistochemical analysis, it was found that IQGAP1 is highly expressed in colorectal cancer and is associated with cancer invasion (Nabeshima, K., et al., Cancer Lett., 176:101-109, 2002). Since the invasiveness of cancer is related to the local disruption of cell-cell adhesion, our results and the data of Iacabuzio-Donahue et al. suggest that IQGAP1 may be involved in the disruption of local adhesion and the invasion of PCs to surrounding tissues. Therefore, a preferred embodiment of the present invention is a marker comprising Seq ID No.27. In another preferred embodiment, the marker comprises Seq ID No.47. In yet another preferred embodiment, the marker comprises SeqID No.55. In addition, in a preferred embodiment, the marker comprises Seq ID No.25.

S100 protein family

Another protein highly expressed in PC is S109 (S100A9, MRP-14, calgranulin B, Seq ID No.49), which is a member of the high-homology and low-molecular-weight calcium-binding protein S100 protein family. Calgranulin is characterized by its cell type-specific expression in cells of epithelial, bone marrow, and endothelial origin and accumulates at sites of acute or chronic inflammation (e.g., rheumatoid arthritis, cystic fibrosis, psoriasis, atopic dermatitis , inflammatory bowel disease) (Donato, R. Int. J. Biochem. Cell Biol., 33637-668, 2001). S100A8 and S100A9 form a non-covalent heterodimeric protein complex called calprotectin. According to current reports, both S100A9 and S100A8 may have extensive intracellular or extracellular functions (Schafer, B.W. and Heizmann, C.W. Trends Biochem. Sci., 21:134-140, 1996). S100A8 and S100A9 are negatively regulated by glucocorticoids in a c-Fos-dependent manner, and are highly expressed during skin carcinogenesis (Gebhardt, C., et al., Oncogene, 21:4266-4276, 2002). These proteins are also more strongly expressed in colon cancer than in the corresponding normal colonic mucosa, as shown by proteomic analysis (Stulik, J. et al., Electrophoresis, 20: 1047-1054, 1999). S100A9 has been detected in adenocarcinoma (AC) cell cultures from various human organs and is associated with tumor differentiation in lung adenocarcinoma (Arai, K. et al., Oncol. Rep., 8:591 -596, 2001). The research work of Iacobuzio-Donahue et al. showed that the high expression of S100A9 in PC is related to its poor differentiation and the degree of DNA hypomethylation (Rosty, C. et al., Am.J.Pathol., 160:45-50, 2002) . Therefore, a preferred embodiment of the present invention is a marker comprising Seq ID No.49.

We found that Annexin 1 (Seq ID No.51) and Annexin 2 (Seq ID No.19) were highly expressed in PC. Both are members of the Ca2+-dependent membrane-bound protein family. In particular, functions described include important roles in malignant transformation (Masaki, T. et al., Hepatology, 24:72-81, 1996), control of proliferation of epithelial cell lines (Solito, E. et al., Cell Growth Differ ., 9:327-336, 1998), and the mediation of apoptosis (Canaider, S., et al.,. Life Sci., 66:L265-L270, 2000). The evidence supporting the causal role of either annexin in carcinogenesis remains circumstantial. In MCF-7 breast cancer cells, high expression of annexin 1 leads to a block of Ca ⁺ release following activation of purinergic receptors or bradykinin receptors (Frey, BM et al., FASEB J., 13:2235 -2245, 1999), whereas high expression of annexin 1 in murine fibroblasts resulted in direct inhibition of cytoplasmic PLA2 and subsequently the serum response element of c-fos (Oh, J. et al., FEBS Lett., 477 : 244-248, 2000).

Taken together, these studies imply a growth-inhibitory effect on annexin. These findings are not supported by the finding that annexin 1 is expressed in prostate cancer cell lines (Vaarala, M.H., LabInvest, SO: 1259-1268, 2000), esophageal cancer (Emmert-Buck, M.R., et al. ., Mol.Carcinog., 27:158-165, 2000), gastric cancer cell lines (Sinha, P., et al., J.Biochem.Biophys.Methods, 37:105-116, 1998), mammalian adenocarcinoma (Pencil, S.D. and Toth, M. Clin. Exp. Metastasis, 16:113-121, 1998) and strongly increased expression in liver cancer (de Coupade, C. et al., Hepatology, 31:371-380, 2000). Liver cancer studies have also shown that the proliferation rate of both normal and malignant hepatocytes is reduced by an annexin-1 antisense strategy.

These results above and our data show that the growth of cells is related to the increase of annexin 1, rather than its decrease. This argument has also been supported by Iacobuzio-Donabue et al. 2002) research institute support. Therefore, a preferred embodiment of the present invention is a marker comprising Seq ID No.51. In another preferred embodiment, the marker comprises Seq ID No. 19.

Other proteins that are highly expressed in PC may have a clear role in PC, or have indirect links with PC, such as BGH3 (TGFβ1-induced protein, Seq ID No. 6), which is a secreted protein and can be used as Labeling of biologically active TGF-β1 (Langham, R.G., et al., Transplantation, 72:1826-1829, 2001). Therefore, a preferred embodiment of the present invention is a marker comprising Seq ID No.6.

Utilizing the identification of polypeptides that are differentially expressed in pancreatic cancer, the present invention provides a method for diagnosing pancreatic cancer and/or susceptibility to pancreatic cancer in vitro, the method comprising the steps of: obtaining a biological sample; detecting and/or measuring the above-mentioned markers for increased expression as described above. As used herein, the term "detecting" refers to specifically determining the absence or presence of a polypeptide. The term "measuring" as used herein refers to the quantitative determination of the difference in the expression of a polypeptide in a biological sample of a pancreatic cancer patient versus a biological sample of a healthy individual. Methods for detecting and measuring polypeptides in biological samples are well known in the art, including, but not limited to, Western blot, ELISA or RIA. Antibodies capable of recognizing polypeptides listed in Tables 2, 3, 5, and/or 6 may be antibodies produced for the purpose of detecting the indicated polypeptides, for example, by immunizing rabbits with purified proteins, or known Antibodies that recognize the indicated polypeptide. For example, an antibody capable of binding a denatured protein, such as a polyclonal antibody, can be used to detect a polypeptide of the invention in a Western blot. An example of a method of measuring a certain marker is ELISA. This type of protein quantification is based on an antibody that captures a specific antigen, and a secondary antibody that detects the captured antigen. Yet another method of detecting a marker for the diagnosis of pancreatic cancer is by analyzing a biopsy sample for the presence of the marker of the invention. Methods for detecting these markers are well known in the art and include, but are not limited to, immunohistochemistry or immunofluorescence to detect the presence or absence of a labeled polypeptide of the invention. The preparation and use methods and analysis methods of the above-mentioned antibodies are described in Harlow, E and Lane, D. Antibodies: A Laboratory Manaal, (1988), published by Cold Spring Harbor Laboratorg. By analyzing a mixture of multiple polypeptides listed in Tables 2, 3, 5 and/or 6, the accuracy of pancreatic cancer diagnosis can be improved. Thus, the in vitro method described above comprises a marker comprising at least 2, preferably at least 3 for quaternary, preferably at least 4 for tertiary, preferably at least 5 for secondary, and preferably at least 6 for primary. A polypeptide listed in 2, 3, 5 and/or 6.

For the diagnosis of pancreatic cancer, appropriate biological samples need to be analyzed for the presence or absence of certain markers. The biological sample referred to may be serum, plasma, pancreatic juice or cells of pancreatic tissue. Pancreatic tissue-derived cells can be obtained by ERCP, secretin stimulation, fine-needle aspiration, cell perturbation, and large-bore needle biopsy.

Pancreatic cancer can also be diagnosed by detecting and/or measuring nucleic acid molecules encoding the markers described above, preferably RNA or DNA. In another embodiment, the DNA referred to is cDNA.

In one embodiment of the present invention, the in vitro method described above comprises: comparing the expression level of at least two nucleic acids encoding the indicated polypeptides in individuals suspected of having pancreatic cancer and/or susceptible to pancreatic cancer with the same nucleic acid Expression levels in healthy individuals.

In another embodiment of the present invention, the in vitro method described above comprises: comparing the expression level of the indicated marker in individuals suspected of having pancreatic cancer and/or susceptible to pancreatic cancer with the expression level of the same marker in healthy individuals level. In a tertiary preferred embodiment of the in vitro method, an increase or decrease in the expression level of the indicated marker is indicative of pancreatic cancer and/or a susceptibility to pancreatic cancer.

The present invention also provides a screening method for identifying and/or obtaining compounds that interact with the polypeptides listed in Table 2 and/or 3, wherein the expression of the polypeptides listed in Table 2 and/or 3 in pancreatic cancer is expression Addition, the method comprising the steps of: contacting a referenced polypeptide with one or more chemicals under conditions enabling the interaction; and then detecting the interaction between the compound or compounds and the referenced polypeptide .

"Interaction" in the screening methods described here can be measured by conventional methods, as opposed to detection of membrane-bound polypeptides, the type of conventional method for detecting the interaction of compounds with soluble polypeptides, which can be the use of purified recombinant polypeptides, or an in vitro method of purifying a native polypeptide from cells endogenously expressing the polypeptide. As a non-limiting example, a polypeptide of the invention can be bound to a bead or immobilized on a plastic or other surface, and the interaction of the compound with the polypeptide can be performed by using a labeled compound and measuring the label bound to the polypeptide assay, or by displacing a labeled known ligand on the polypeptide.

For polypeptides that are bound to the cell membrane on the cell surface, or expressed as transmembrane or intramembrane polypeptides, the interaction of the compound with the indicated polypeptide can be detected by various methods including, but not limited to, using normal A method of expressing a polypeptide or a cell in which a polypeptide is highly expressed, for example, by measuring the rate of displacement of a known ligand labeled with a compound to be screened.

Alternatively, membrane preparations can be used to test the interaction of compounds with such polypeptides. Interaction assays employed in the methods disclosed here may include: FRET assays (fluorescence resonance energy transfer (fluorescence resonance energy tranfer); especially, as in Ng, Science 283 (1999), 2085-2089 or Ubarretxena-Belandia, Biochem .38 (1999), 7398-7405), TR-FRET, and the biochemical assays disclosed therein. In addition, commercially available assay products such as "Amplified Luminescent Proximity Homogenous Assay ^™ " (BioSignal Packard) can also be used. In addition there are methods well known in the art, inter alia, as described in Fernandez, Curr. Opin. Chem. Biol. 2 (1998), 547-603.

"Determination of interaction" can also be performed by specific immunological and/or biochemical assays well known in the art, including, for example, homogeneous and heterogeneous assays as described below. The methods of interaction analysis using readout systems referred to are well known in the art and include inter alia double hybrid screening (as described, inter alia, in EP-0 963 376, WO 98/25947, WO 00/02911; and as described in Illustrated in the appended examples), inter alia, GST-depression column, co-sedimentation assay of cell extracts, "interaction-capture" as described in Kasus-Jacobi, Oncogene 19 (2000), 2052-2059 Systems (eg, as described in US 6,004,746), expression cloning (eg, lambda gt11), phage display (eg, as described in US 5,541,109), in vitro binding assays, etc. Further interaction assays and their corresponding readout systems are described inter alia in US 5,525,490, WO 99/51741, WO 00/17221, WO 00/14271 or WO 00/05410, Vidal and Legrain (1999) in Nucleic Acids Other interaction assays known in the art are described, reviewed and summarized in Research 27, 919-929, which can be employed in accordance with the present invention.

Homogeneous (interaction) assays include assays in which the bound pair remains in solution, and include assays such as agglutination assays. Heterogeneous analytical methods include, inter alia, immunoassays such as enzyme-linked immunosorbent assay (ELISA), radioimmunoassay (RIA), immunoradiometric assay (IRMA), flow injection analysis (FIA), flow activated cell sorting ( FACS), chemiluminescence immunoassay (CLIA) or electrochemiluminescence (ECL) and other analytical methods.

The present invention also provides a screening method for identifying and/or obtaining a certain compound, which is an inhibitor or antagonist of the polypeptide listed in Table 2 and/or 3, and the expression of the polypeptide in pancreatic cancer is expressed as Increase. The screening method comprises the following steps: a) contacting the indicated polypeptide with the compound identified and/or obtained by the above-mentioned screening method under conditions that allow the compound to interact with the indicated polypeptide; b) measuring the activity of the indicated polypeptide activity; c) as defined in (a), determining the activity of the indicated polypeptide expressed in a host that has not been contacted with the indicated compound; d) quantitatively relating the activities measured in (b) and (c) , wherein a lower activity measured in (b) than in (c) indicates that the compound is an inhibitor or antagonist. As used herein, the terms inhibitor and antagonist are used interchangeably. Such screening assays can be performed as in vitro assays or as host-based assays. The host used in the screening method of the present invention, comprising and/or expressing the polypeptide listed in Table 2, 3, 5 and/or 6, may include prokaryotic and eukaryotic cells, and the cells referred to may include bacterial cells, yeast cells , and cultured (tissue) cell lines, especially cultured (tissue) cell lines derived from mammals. In addition, animals can also be used as hosts, eg, non-human, transgenic animals. Thus, the host (cell) in question can be transfected or transformed with a vector comprising a nucleic acid molecule encoding a polypeptide that is differentially regulated in pancreatic cancer as disclosed herein. Accordingly, the host cell or host referred to may be genetically modified with a nucleic acid molecule encoding such a polypeptide or with a vector comprising such a nucleic acid molecule. The term "genetic modification" means that the host cell or host comprises, in addition to its native genome, a nucleic acid molecule or vector encoding a polypeptide listed in Tables 2, 3, 5 and/or 6 or at least a fragment thereof. The additional genetic material referred to may be introduced into the host (cell) or into one of its predecessors/parents. The nucleic acid molecule or vector can exist as an independent molecule outside the genome, preferably as a molecule that can be replicated, or can be stably integrated into the genome of the host cell or host and present in the genetically modified host cell or host.

As mentioned above, the host cell of the present invention can be any kind of prokaryotic or eukaryotic cell. Prokaryotic cells commonly used for cloning of Escherichia coli, Bacillus, etc. are suitable prokaryotic cells. However, the use of these prokaryotic host cells is also contemplated in the screening methods disclosed herein. Furthermore, eukaryotic cells include, for example, fungal or animal cells. Examples of suitable fungal cells are yeast cells, preferably yeast cells of the genus Saccharomyces, preferably yeast cells of the species Saccharomyces cerevisiae. Suitable animal cells are eg insect cells, vertebrate cells, preferably mammalian cells, eg CHO, Hela, NIH3T3 or MOLT-4. Other suitable cell lines known in the art are available from cell line collections, such as the American Type Culture Collection (ATCC).

The host may also be selected from non-human mammals, preferably mice, rats, sheep, calves, dogs, monkeys or apes. As mentioned above, references to animals/mammals also include non-human transgenic animals, preferably expressing at least one polypeptide disclosed herein that is differentially regulated in pancreatic cancer. Preferably, the polypeptide referred to is one whose expression is increased in pancreatic cancer patient tissue. However, transgenic animals produced that do not express the marker genes disclosed herein, or that express limited amounts of the indicated marker gene products, are also contemplated. Preferably the animal referred to is related to a polypeptide negatively regulated in pancreatic cancer. Transgenic non-human animals comprising and/or expressing an expression-enhancing polypeptide of the invention, or, alternatively, a silent or inefficient form of a negative regulatory polypeptide, are useful models for studying the development of pancreatic cancer, and for testing for treatment and prevention Drugs and therapies for pancreatic cancer provide useful models.

A compound that interacts with a polypeptide listed in Tables 2, 3, 5 and/or 6 and inhibits or antagonizes the indicated polypeptide is identified by measuring the activity of the indicated polypeptide in the presence of the compound. The term "activity" as used herein relates to the one or more functional properties of the polypeptide in question. For the enzymes listed in Tables 2, 3, 5 and/or 6, the term "activity" relates to the enzymatic activity of the specific polypeptide. Assays for the activity of the enzymes listed in Tables 2, 3, 5 and/or 6 are well known.

For the adhesion molecules listed in Tables 2, 3, 5 and/or 6, the term "activity" refers to the adhesion properties of the polypeptide concerned and can be determined by analytical methods such as, but not limited to, adhesion assays, cell diffusion assays , or in vitro interactions of adhesion molecules with known ligands. These analytical methods are well known in the art.

For cytoskeletal proteins, the term "activity" relates to regulation of the cytoskeleton by such polypeptides, or to their incorporation into the cytoskeleton. As a non-limiting example, the ability of gelsolin to regulate actin polymerization, or the ability of actin A to promote crosslinking of actin fibers, can be determined using an in vitro actin polymerization assay. As a non-limiting example, activities related to the regulation of cytoskeletal structure can be further analyzed by cell diffusion assays, cell migration assays, cell proliferation assays or immunofluorescence assays, or by the use of fluorescently labeled phalloidin on muscle activity. Protein fibers were stained for determination. All of these analytical methods are well known to those skilled in the art.

For ion channels (chloride channel proteins), the term "activity" relates to the flux of ions across the membrane (chloride flux). Methods for measuring ion flux across membranes are well known to those skilled in the art.

For a transcription factor, eg, KIAA1034, the term "activity" relates to its ability to regulate gene transcription. The transcriptional activity of a polypeptide can be determined by commonly used assays, such as reporter gene assays.

With respect to growth factors and hormones or their receptors, the term "activity" is related to their ability to bind their receptors or ligands respectively, and to their ability to induce receptor activation, subsequent signaling cascade, and/or it relates to the factor's or the receptor's ability to mediate the one or more cellular functions ultimately resulting from growth factor or hormone-mediated activation of the receptor. The growth factor or hormone bound to the receptor can be determined by commonly known ligand binding assays. Activation of the receptor can be measured by detecting receptor autophosphorylation, or by analyzing the modification or recruitment of downstream signaling mediators of the receptor (by immunoprecipitation and Western blotting of the signaling complex). Cellular functions regulated by growth factors or hormones and their receptors can be measured by cell proliferation (e.g., measured by thymidine incorporation or cell counting), cell migration assays (e.g., by a modified Boyden chamber), cell survival, or apoptosis Assays (eg, assayed by DAPI staining), angiogenesis assays (eg, in vitro assays to measure endothelial tube formation, commercially available). In addition to these assays, other assays can be used to measure these and other cellular functions.

Inhibitors or antagonists of the polypeptides listed in Table 2 and/or 3 can be identified by the above-mentioned screening method. When the compound exists, the activity measured in the screening method is lower than that when the compound does not exist, indicating that the compound is present. The compounds are either inhibitors or antagonists.

For the screening method disclosed above, the present invention further provides a screening method for identifying and/or obtaining a certain compound, which is an expression inhibitor of the polypeptide listed in Table 2 and/or Table 3, and the expression of the polypeptide indicated Increased expression in pancreatic cancer. The method comprises the steps of: a) contacting a host expressing the polypeptide with a compound; b) determining the expression level and/or activity of the polypeptide; c) determining the presence of the polypeptide in the host as defined in a). the expression level and/or activity of the host that has not been contacted with the indicated compound; d) quantitatively correlating the expression levels of the indicated polypeptide determined in b) and c), wherein the expression level determined in (b) is compared to A low measured in (c) indicates that the compound is an expression inhibitor of the indicated polypeptide.

Inhibitors of the expression of polypeptides listed in Tables 2, 3, 5 and/or 6 are identified by the screening method described above, in which the expression of the protein measured in the presence of the compound is reduced compared to the absence of the compound, then It shows that the compound is an expression inhibitor of polypeptide.

The term "expression" as used herein relates to the expression level of the polypeptides listed in Tables 2, 3 and/or 6, in pancreatic cancer, in cells, preferably in pancreatic cancer cell lines, the expression level of which is increased Higher than the expression level of the same polypeptide in healthy pancreatic cells, the expression level of the fourth grade is preferably at least 2 times higher than the expression level in healthy pancreatic cells, the third grade is preferably at least 3 times higher, the second grade is preferably at least 4 times higher, One level is preferably at least 5 times higher.

Furthermore, the present invention provides a compound identified and/or obtained by any one of the screening methods described above. The indicated compounds are further comprised in pharmaceutical compositions. The present invention also claims a method for preparing the said pharmaceutical composition, which comprises formulating the said compound together with a pharmaceutically acceptable carrier or diluent. Any conventional carrier material can be used. The carrier material may be an organic or inorganic material suitable for enteral, transdermal or parenteral administration. Suitable carriers include water, gelatin, gum arabic, lactose, starch, magnesium stearate, talc, vegetable oils, polyalkylene glycols, petrolatum, and the like. In addition, the pharmaceutical formulation may contain other pharmaceutically active agents. Other additives such as flavoring agents, stabilizers, emulsifiers, buffers, etc. can be added in accordance with generally accepted pharmaceutical compounding practices.

The indicated compounds can be used to prepare medicaments for treating or preventing pancreatic cancer. Furthermore, the compounds referred to can also be used in the preparation of diagnostic compositions for the diagnosis of pancreatic cancer or a predisposition to pancreatic cancer. Preferably the compounds referred to comprise antibodies, antibody derivatives, antibody fragments, peptides or antisense constructs.

Within the scope of the present invention, antibodies to the proteins listed in Table 2 and/or Table 3, or antigen-binding fragments thereof, can be used in methods for in vitro diagnosis of pancreatic cancer.

In order to efficiently perform diagnostic screening, the present invention provides a kit for diagnosing pancreatic cancer, which comprises one or more of the above-mentioned antibodies, or antigen-binding fragments thereof. Another kit for diagnosing pancreatic cancer provided by the present invention is a kit comprising one or more nucleic acids encoding the markers described above. The present invention also provides a kit for screening compounds against any one of the polypeptides listed in Table 2 and/or Table 3, or inhibiting the expression of any one of the indicated polypeptides.

The present invention relates to a marker for diagnosing pancreatic cancer, which comprises at least one polypeptide selected from Table 6. Preferably the markers referred to do not include Seq ID No. 25 and 50-55. In a third preferred embodiment, the marker in question comprises at least one polypeptide listed in Table 5.

The present invention also provides a method for in vitro diagnosis of pancreatic cancer and/or susceptibility to pancreatic cancer, the method comprising the following steps:

a) Obtaining a biological sample

b) detecting and/or measuring an increase in at least one polypeptide listed in Table 6.

Quadruple preference refers to in vitro methods that additionally comprise the step of detecting and/or measuring the reduction of at least one polypeptide listed in Table 5. Tertiary preferred In the in vitro method referred to, the at least one polypeptide referred to does not comprise Seq ID No. 25 and 50-55. Secondary preference, in the indicated in vitro method, the indicated biological sample is derived from serum, plasma, pancreatic juice and pancreatic tissue cells.

The present invention further provides a method for diagnosing pancreatic cancer and/or susceptibility to pancreatic cancer, the method comprising the following steps:

a) obtaining a biological sample; and

b) Detecting and/or determining an increase in at least one nucleic acid encoding the marker indicated above.

Preferably, in the in vitro method referred to, the nucleic acid molecule referred to is RNA or DNA, tertially preferably in the in vitro method referred to, the DNA referred to is cDNA.

In another thirdly preferred embodiment of any one of the in vitro methods described above, the expression level of at least one nucleic acid referred to in an individual suspected of having pancreatic cancer and/or susceptible to pancreatic cancer is compared to the same The expression levels of nucleic acids in healthy individuals were compared. In a highly preferred embodiment of any one of the in vitro methods described above, the expression level of the indicated marker in individuals suspected of having and/or susceptible to pancreatic cancer is compared to the same marker in healthy individuals expression levels were compared.

In a third preferred embodiment of the in vitro method described above, the increased expression level of the indicated marker is indicative of pancreatic cancer and/or a susceptibility to pancreatic cancer.

The present invention also relates to a screening method for identifying and/or obtaining a certain compound, the compound interacts with the polypeptides listed in Table 6, and the expression of the indicated polypeptides is increased in pancreatic cancer. The method comprises the following steps:

a) contacting the referenced polypeptide with one or more compounds under conditions that allow the compound to interact with the referenced polypeptide; and

b) detecting the interaction between the indicated compound or compounds and the indicated polypeptide.

In addition, the present invention provides a screening method for identifying and/or obtaining a certain compound, the compound is an inhibitor or antagonist of the polypeptide listed in Table 6, and the expression of the polypeptide is increased in pancreatic cancer, The method includes the following steps:

a) contacting the indicated polypeptide with the compound identified and/or obtained by the screening method of claim 39 under conditions under which the indicated compound and the indicated polypeptide can interact;

b) determining the activity of the polypeptide in question;

c) determining the activity of the indicated polypeptide expressed in a host, as defined in a), which polypeptide has not been brought into contact with said compound; and

d) Quantitatively linking the activities measured in b) and c), wherein a lower activity measured in b) than c) indicates that the compound is an inhibitor or antagonist.

The present invention also provides a screening method for identifying and/or obtaining a certain compound, the compound is an expression inhibitor selected from the polypeptides listed in Table 6, and the expression of the indicated polypeptide is increased in pancreatic cancer, the method includes The following steps:

a) contacting a host expressing the indicated polypeptide with a compound;

b) determining the expression level and/or activity of the polypeptide in question;

c) determining, as specified in a), the expression level and/or activity of the polypeptide in question in a host that has not been contacted with said compound; and

d) Quantitatively correlating the expression levels of the indicated polypeptide determined in b) and c), wherein a lower expression level measured in b) than in c) indicates that the compound is an expression of the indicated polypeptide expression inhibitors.

The present invention provides a compound identified and/or obtained by the screening method described above.

Furthermore, the present invention provides a pharmaceutical composition comprising a compound as described above. Also provided is a method for preparing the above-mentioned pharmaceutical composition, the method comprising formulating the above-mentioned compound together with a pharmaceutically acceptable carrier or diluent.

The present invention provides the use of the compound described above in the preparation of a medicament for treating or preventing pancreatic cancer. The present invention also provides the use of the compound described above in the preparation of a diagnostic composition for diagnosing pancreatic cancer or a tendency to suffer from pancreatic cancer. In a preferred embodiment, the above-mentioned uses relate to compounds comprising antibodies, antibody derivatives, antibody fragments, peptides or antisense constructs.

Within the scope of the present invention, antibodies to the proteins listed in Table 5 and/or 6, or antigen-binding fragments thereof, can be used in methods for diagnosing pancreatic cancer in vitro.

In order to effectively perform diagnostic screening, the present invention provides a kit for diagnosing pancreatic cancer, which comprises one or more of the above-mentioned antibodies, or antigen-binding fragments thereof. Another kit for diagnosing pancreatic cancer provided by the present invention is a kit comprising one or more nucleic acids encoding the markers described above. Also provided by the present invention is a kit for screening compounds against any one of the polypeptides listed in Table 5 and/or Table 6, or inhibiting the expression of any one of the indicated polypeptides.

In the present invention, basically the proteins, compounds, kits, methods and uses described above, especially the above-mentioned examples, are all claimed.

Detailed ways

Tissue Sample Collection

Pancreatic cancer and adjacent normal pancreas tissues were collected from the patients listed in Table 1. Samples were collected immediately (less than 30 min) after excision and snap-frozen in liquid nitrogen for about 1 min before being stored in a freezer at -80°C.

Formalin-fixed samples

Sections of formalin-fixed and paraffin-embedded samples were stained with hematoxylin and eosin for histopathological characterization. Tumors were classified using the WHO system, and the types of pancreatic cancer included in this study are shown in Table 1.

The 12 pancreatic cancer samples used in this study were ductal carcinomas constituting a predominant part of pancreatic cancer. Paired samples of pathologically normal tissue surrounding pancreatic cancer from patients were used as controls.

We performed the determination of 12 pairs of 2-D electrophoresis patterns to compare protein expression between tumor tissues and normal control tissues. For protein identification, samples can be pooled, thereby yielding a total cancer extract and a total normal protein extract. Then quantify according to the following two steps: (1) use PDQuest imaging analysis software to compare the gels of each concentrated sample. (II) Cross-determination of changes identified at pooled sample level by analysis of each sample. The fold changes shown in Tables 2, 3, 5 and 6 were determined using pooled samples.

Electrophoresis sample preparation

The samples, freed of blood clots and contaminating tissue, were frozen in liquid nitrogen and ground into a powder. The sample was suspended in lysis buffer (8M urea, 4% CHAPS, 40mMol/L Tris-Cl, 0.5% carrier ampholyte, 100mM/LDTT and 0.1ig/il PMSF), and centrifuged at 1200rpm for 30 minutes, the supernatant Store at -80°C. The protein concentration in the extract was determined by the Bradford method (Bradford, M. Anal. Biochem. 72, 248, 1976).

two-dimensional gel electrophoresis

Samples containing 1 mg of protein were loaded onto rehydrated IPG strips (18 cm, pH 3-10) using the cup loading method. Isoelectric focusing electrophoresis (IEF) was carried out with a Pharmacia Multiphor device under the following conditions: firstly, the voltage was increased by 200-5000V for 24 hours, and then a constant voltage of 5000V was applied for 24 hours, and the electrophoresis temperature was 20°C. After IEF, the strips were equilibrated with 10ml equilibration solution I (6M urea, 50mM Tris pH8.8, 30% glycerol, 2.0% SDS, 30mM dithiothreitol) for 15 minutes, and then equilibrated with equilibration solution II (6M urea, 50mM Tris pH 8.8, 30% glycerol, 2.0% SDS, 0.23M iodoacetamide) re-equilibrated for 15 minutes.

The SDS-polyacrylamide gel electrophoresis (SDS-PAGE) in the second direction was carried out with Hoefer ISO-DALT device (10 gels/time, 24×20cm), and the IEF strips were placed in a 12% homogeneous polyacrylamide gel (1.5mm×24cm×20cm). Gel electrophoresis was performed in TGS-buffer (250mm Tris, 1.92M glycine, 1% (w/v) SDS, pH=8.3, Bio Rad) at constant voltage (80V, 20°C).

Gel fixation and staining

Gels were fixed in 50% methanol/20% acetic acid for 30 minutes, washed in ultrapure water for 30 minutes, and stained with the NOVEX Colloidal Blue staining kit (Invitrogen) according to the manufacturer's recommendations.

protein identification

Protein identification was performed using a two-step method.

in-gel digestion

The gel spots were picked by an automatic pick-up device and transferred to a 96-well plate. 600-800 spots were picked for each gel, and the gel spots were decolorized with 100 μl of 30% acetonitrile solution dissolved in 50 mM ammonium bicarbonate, washed with ultrapure water, and then dried in a fast vacuum evaporator. The wafers were digested with a solution of 10 ng/μl trypsin (Promega, Madison, USA) in 50 mM ammonium bicarbonate for a maximum of 16 hours at room temperature. Peptides from each gel spot were extracted with 20 [mu]l of 0.1% trifluoroacetic acid (TFA) in 50% acetonitrile. The matrix solution contained 0.025% (w/v) α-cyano-4-hydroxycinnamic acid (Sigma) in 50% acetonitrile/0.1% TFA, and contained the internal standard peptide desarginine bradykinin (Sigma, MW904 .4681 Da) and corticotropin fragment 18-39 (Sigma, MW2465.1989 Da).

MALDI-TOF analysis

1.5 μl of peptide extract and 1.0 μl of matrix solution were simultaneously added to the spot of the MS target. Recrystallization was performed according to the manufacturer's instructions. Samples were analyzed within MALDI time of a flight mass spectrometer (Autoflex, Bruker, Analytics, Bremen, Germany). Peak annotation and database searches by peptide matching were performed using in-house developed software. The mass of the peptide is compared to the theoretical mass of the peptide for all proteins available for each species. Using the mass of a single isotope, the allowable mass deviation is 0.0025%. A determination of identity requires at least 4 matching peptides. Mismatch or miscut sites were not taken into account.

Table 1: Clinical and histopathological characteristics of the samples sample number gender age tumor site Histology Lymph node metastasis PC-01 male 48 pancreatic head moderately differentiated ductal adenocarcinoma yes PC-02 male 68 pancreatic head poorly differentiated adenocarcinoma yes PC-03 male 44 pancreatic head poorly differentiated ductal adenocarcinoma, clear cell type yes PC-04 male 66 pancreatic head well differentiated ductal adenocarcinoma yes PC-05 female 45 pancreatic head well differentiated ductal adenocarcinoma no PC-06 female 65 pancreatic head well differentiated ductal adenocarcinoma yes PC-07 male 59 pancreatic head moderately differentiated ductal adenocarcinoma yes PC-08 female 62 pancreatic body well differentiated ductal adenocarcinoma yes PC-09 male 54 pancreatic head moderately differentiated ductal adenocarcinoma no PC-10 female 53 pancreatic head well differentiated ductal adenocarcinoma no PC-11 female 54 pancreatic head moderately differentiated ductal adenocarcinoma yes PC-12 female 69 pancreatic head moderately differentiated ductal adenocarcinoma yes

Table 2 Protein I positively regulated in pancreatic cancer protein Acc No illustrate SeqIDNo change multiple sw: CATD_People P07339 Cathepsin D precursor (EC 3.4.23.5) 1 <2 sw: IDHC_person O75874 Cytoplasmic isocitrate dehydrogenase [NADP] (ec1.1.1.42) 2 2 sw: GELS_People P06396 plasma gelsolin precursor 3 3 sw: CFAB_People P00751 Complement factor B precursor (ec 3.4.21.47) 4 5 sw:AAC4_People O43707 α-actinin 4 (non-muscle α-actinin 4) 5 2 sw:AAC1_person P12814 α-actinin 1 (α-actinin cytoskeletal isoform) 7 2 sw: TBA4_people P05215 Tubulin alpha-4 chain 8 2 sw: ABP2_People P21333 Filamin A (endothelial actin-binding protein) 9 4 sw: TAGL_People P37802 Transgelin 2 (smooth muscle protein 22-α) 10 2 sw: TPM4_person P07226 tropomyosin alpha 4 chain 11 <2 sw: BGH3_people Q15582 Transforming growth factor-beta-induced protein IG-H3 precursor 6 5 sw: CALD_Person Q05682 Calmodulin (cdm) 12 2 sw: ENOL_People Q05524 α-enolase 13 2 sw: ACY1_People Q03154 aminoacylase-I 14 5 sw: CAPB_People P47756 F-actin capping protein β subunit (capzβ) 15 5 sw: IPYR_People Q15181 Inorganic pyrophosphatase 16 <2 sw:LEG3_people P17931 Galectin 3 (galactose-specific lectin 3) 17 2 sw: POR2_person P45880 Voltage-dependent anion-selective channel protein 2 18 <2 sw: ANX2_People P07355 Annexin II 19 2 sw: CBP2_Person P50454 procollagen binding protein 2 20 2 sw:COF1_person P23528 non-muscle isoform Cofilin twenty one <2 sw: DYPH_People P05092 peptidylproline cis-trans isomerase A twenty two <2 sw: DYI2_People Q13409 cytoplasmic dynein intermediate chain 2 twenty three 2 sw: ECH1_person Q13011 Mitochondrial delta 3,5-delta 2,4-dienol-CoA isomerase precursor twenty four 2 sw: MLRN_People P24844 Myosin-regulated light chain 2 48 2 sw: PLSL_People P13796 L-plastin 26 <2 sw: RAN_People P17080 GTP-bound nuclear protein ran 27 3 sw: ROK_people Q07244 heterogeneous nuclear ribonucleoprotein K 28 2 sw: TCTP_People P13693 translationally regulated tumors 29 <2 sw:TPM1_Person P09493 tropomyosin 1 alpha chain 30 <2 sw: TYPH_People P19971 Thymidine phosphorylase precursor 31 5 sw:AMPL_People P28838 cytosolic aminophthalein 32 3 sw: KICS_people P08727 Type I cytoskeleton 19 keratin (cytokeratin 19) 33 4 sw:ALDX_People P14550 Alcohol dehydrogenase [NADP+] 34 4 sw: EL3A_People P09093 Elastase IIIa precursor 35 4 :dldh_person P09622 mitochondrial dihydrolipoamide dehydrogenase precursor 36 2 sw: ECHM_People P30084 Mitochondrial enoyl-CoA hydratase precursor 37 3 sw:HSBX_People O14558 heat shock-like 20kda protein p20 38 2 sw: MLEN-person P16475 non-muscle isoform basic myosin light chain 39 3 sw: calx-human P27824 pro-calnexin 40 3 sw: MA32-person P07021 complement component 1 41 <2 sw: NUAM-person P28331 Mitochondrial NADH coenzyme Q oxidoreductase 75kDa subunit precursor 42 2 sw:PBEF-person P43490 pre-B cell enhancer factor precursor 43 2 sw: RET1-person P09455 cellular retinol binding protein I 44 2 Sw: TCPG-human P49368 T-complex protein 1, gamma subunit 45 2 Sw: RINI-person P13489 placental ribonuclease inhibitor 46 <2 Sw: GBLP-person P25388 Guanine-like nucleotide-binding protein beta subunit protein 12.3 47 2 Sw: S109-person P06702 calgranulin B 49 <2

Table 3: Protein II Upregulated in Pancreatic Cancer protein Acc No illustrate SeqID No. multiple of change sw: CAPG_Person P40121 macrophage capping protein 50 3 sw: ANX1_People P04083 Annexin I (lipocortin I) (calcadin II) 51 4 sw: K2C7_People P08729 Type II cytoskeleton 7 keratin 52 5 Humangp: CHR13_Q15063 Q15063 osteoblast specific factor 2 precursor 53 2 sw: TGLC_People P21980 protein-glutamine gamma-glutamyltransferase 54 2 sw: GDIR_People P52565 Rho GDP dissociation inhibitor 1 55 <2 sw: IQG1_person P46940 Ras-like GTPase activator protein 25 2

Table 4 Rough classification of proteins according to the biological process or basic function they participate in protein function ^a protein species ^b Percentage (%) ^c Structural composition and regulation of the cytoskeleton 61 20.8 Cell Cycle and Metabolism 74 25.3 response to external stimuli or stress 61 20.8 Signaling 13 4.4 nuclear function 18 6.1 Transshipment processing 19 6.5 hemostasis 12 4.1 cell adhesion 7 2.4 chaperone protein 7 2.4 apoptosis 3 1 unknown function 11 3.7 other 7 2.4 total 293 100

Table 5 Proteins with higher levels in normal pancreatic tissue than in cancerous tissue protein ^a Acc No ^b description ^c multiple ^d Seq ID No Cytoskeleton regulation sw: DESM_People P17661 Desmin 3 70 Proteolysis and peptide cleavage sw: CBPB_People P15086 carboxypeptidase b precursor 2 71 sw: CBP1_Person P15085 carboxypeptidase a1 precursor not calculated 72 sw: CPB2_people P50454 carboxypeptidase a2 precursor not calculated 73 sw: CTRB_People P17538 chymotrypsinogen b precursor not calculated 74 sw: TRY1_People P07477 Trypsin I precursor (EC 3.4.21.4) (cationic trypsinogen) not calculated 75 sw: TRY2_People P07478 Trypsin II precursor (anionic trypsinogen) 3 76 sw: ILEU_People P30740 leukocyte elastase inhibitor 4 77 chaperone protein sw: CH60_person P10809 Human, mitochondrial matrix protein p1 precursor 2 78 sw: ENPL_People P14625 94kda glucose-regulated protein 3 79 sw: ER29_person P30040 endoplasmic reticulum protein erp29 precursor 2 80 sw: PDA2_person Q13087 protein disulfide isomerase a2 precursor 2 81 sw: PDA3_person P30101 protein disulfide isomerase a3 precursor 2 82 oxidoreductase sw: ADHB_People P00325 alcohol dehydrogenase beta chain 2 83 sw: GTO1_people P78417 Glutathione transferase omega 1 not calculated 84 sw: OXRP_People Q9Y4L1 150kda oxygen regulated protein precursor not calculated 85 sw:PDX4_Person Q13162 peroxiredoxin 4 <2 86 sw:ULA4_Person P30039 Mawd binding protein <2 87 metabolism of biological processes sw:AMYC_ P19961 alpha-amylase 2b precursor 3 88 people sw:AMYP_People P04746 Pancreatic alpha-amylase precursor not calculated 89 sw:ATPA_People P25705 Mitochondrial ATP synthase alpha chain precursor <2 90 sw: BAL_person P19835 bile salt activated lipase precursor 3 91 sw: L1P1_Person P54315 pancreatic lipase-associated protein 1 precursor <2 92 sw: LIP2_People P54317 pancreatic lipase-associated protein 2 precursor not calculated 93 sw: LIPP_Person P16233 Pancreatic triacylglycerol lipase precursor not calculated 94 sw: DPY2_People Q16555 dihydropyrimidinase-related protein 2 95 sw: GABT_People P80404 4-aminobutyrate aminotransferase 2 96 sw: GATM_people P50440 Mitochondrial glycine amidinyltransferase precursor not calculated 97 sw: GR78_People P11021 78kda glucose-regulated protein precursor (GRP78) 3 98 sw: IF32_People Q13347 eukaryotic translation initiation factor 3 subunit 2 <2 99 sw: DPY2_People Q16555 dihydropyrimidinase-related protein 2 100 sw: PGMU_People P36871 phosphoglucomutase 2 101 sw:PSA1_Person P25786 Proteasome subunit α1 type 2 102 heat shock protein sw:HS27 P04792 heat shock 27kda protein not calculated 103 Signal sw: PD6I Q8WUM4 programmed cell death 6 interacting protein 5 104 muscle development Hsugp: 052687-10-0 Q9bva2 4.5 lim domain 3 <2 105 sw:sli2 Q13643 Skeletal muscle LIM protein 2 (SLIM2) (4.5lim domain protein 3) (PHL3) <2 106 transport of biological processes sw: CYB5_People P00167 cytochrome b5 2 107 cell adhesion sw: PAP1_Person Q06141 pancreatitis-associated protein 1 precursor not calculated 108 other sw: CA16_person P12109 Collagen α1(vi) chain precursor 5 109 sw: LUM_person P51884 basement membrane glycan precursor 3 110

Table 6: Proteins with higher levels in pancreatic cancer than in normal tissues protein ^a Acc No ^b description ^c multiple ^d Seq ID No Cytoskeleton regulation sw: FSC2_People O14926 fascin (retinal fascin) 2 56 sw:AAC1_person P12814 α-actinin 1 2 7 sw:AAC4_People O43707 α-actinin 4 2 5 sw: ABP2_People P21333 Endothelial actin-binding protein (α-filamin) 4 9 sw: ANX2_People P07355 Human annexin ii (lipocortin ii) 2 19 sw: CALD_Person Q05682 Calmodulin (cdm) 2 12 w:capb_people P47756 f-actin capping protein beta subunit 5 15 sw: CAPG_Person P40121 macrophage capping protein 3 50 sw:CPF1_Person P23528 Non-muscle isoform (p18) Cofilin <2 twenty one sw: DEST_People P18282 destrin (actin depolymerization factor) (adf) 2 57 sw: DYI2_People Q13409 Dynein middle chain 2 (fragment) 2 twenty three sw: GELS_People P06396 gelsolin precursor 3 3 sw: K1CS_People P08727 Type I cytoskeleton 19 keratin 4 33 sw: K2C7_People P08729 Type II Cytoskeleton 7 Keratin 5 52 sw: MLEN_People P16475 basic myosin light chain 3 39 sw: PLSL_People P13796 1-plastin (lymphocyte cytoplasmic protein 1) <2 26 sw: TAGL_People P37802 Transgelin (22kda actin-binding protein) 2 10 sw: TBA4_people P05215 tubulin alpha chain 2 8 Proteolysis and peptide cleavage sw:ACY1 Q03154 aminoacylase-1 5 14 sw:AMPL P28838 Cytoplasmic aminophthalein 3 32 sw: CATD P07339 cathepsin d precursor <2 1 sw: CFAB_People P00751 complement factor b precursor 5 4 sw: EL3A_People P09093 elastase iiia precursor 4 35 chaperone protein sw: APE_People P02649 Apolipoprotein e precursor (apo-e) <2 59 sw: CALX_People P27824 Calnexin (p90) precursor 3 40 sw: CYPH_People P05092 Peptidylproline cis-trans isomerase a <2 twenty two sw: TCPG_People P49368 T-complex protein 1, gamma subunit 2 45 sw: CBP2_Person P50454 Human Collagen Binding Protein 2 Precursor 2 20 tr_people Q96C61 Q96C61 Hypothetical 88.6kda protein 5 60 oxidoreductase sw: DLDH_People P09622 dihydrolipoamide dehydrogenase 2 36 sw: IDHC_person O75874 Cytoplasmic isocitrate dehydrogenase (NADP) 2 2 sw: NUAM_people P28331 NADH coenzyme Q oxidoreductase 75kda subunit 2 42 metabolism of biological processes sw:ALDX_People P14550 Alcohol dehydrogenase [NADP+] 4 34 sw: ECH1_person Q13011 δ3,5-.δ2,4-dienoyl-CoA isomerase 2 twenty four sw: ECHM_People P30084 Mitochondrial enoyl-CoA hydratase precursor 3 37 sw: IPYR_People Q15181 Inorganic pyrophosphatase <2 16 sw: TYPH_ P19971 Thymidine phosphatase precursor 5 31 people sw: ENOA_People P06733 human alpha enolase 2 61 sw: ENOL_People Q05524 lung-specific alpha enolase 2 13 sw: SYW_people P23381 tryptophan tRNA synthetase 2 62 heat shock protein sw:HSBX_People O14558 heat shock-like 20kda protein p20 2 38 Signal sw:GBLPP_People P25388 Guanine-like nucleotide-binding protein beta subunit protein 12.3 2 47 sw: GDIR_People P52565 Rho GDP dissociation inhibitor 1 <2 55 w: IQG1_person P46940 Ras-like GTPase-activating protein IQGAP1 2 25 sw:PBEF_People P43490 pre-B cell enhancer factor precursor 2 43 sw: RAN_People P17080 GTP-binding nucleoprotein ran 3 27 immune response sw: KAC_people P01834 Ig kappa chain c domain 2 63 sw: MA32_People Q07021 Pre-mRAN splicing factor sf2, p32 subunit <2 41 inflammatory response sw: ANX1_People P04083 Annexin (lipocortin 1) 4 51 sw:LEG3_People P17931 Galectin 3 2 17 sw: S109_people P06702 Calgranulin b (mrp14) <2 49 muscle development sw:TPM1_Person P09493 tropomyosin 1 alpha chain <2 30 w:TPM4_Person P07226 tropomyosin alpha 4 chain <2 11 sw: MLRN_People P24844 Myosin-regulated light chain 2 2 48 transport of biological processes Humanp: CHR2-Q15092 Q15092 transmembrane protein 2 64 sw: POR2_person P45880 voltage-dependent cation <2 18 subselective channel protein 2 sw: RET1_Person P09455 retinol binding protein I 2 44 RNA processing Humangp: CHR20-Q9P2E9 O75300 Ribosome binding protein I (KIAA1398 protein) <2 65 sw: RIN1_person P13489 placental ribonuclease inhibitor <2 46 sw: ROK_people Q07244 heterogeneous nuclear ribonucleoprotein k 2 28 blood coagulation sw:FIBG_People P02679 fibrinogen gamma chain precursor 3 66 sw: THRB_People P00734 prothrombin precursor <2 67 anti-apoptosis sw: TCTP_People P13693 Translationally regulated tumor protein (p23) <2 29 cell adhesion Humanp: CHR13-Q15063 Q15063 osteoblast specific factor 2 precursor 2 53 sw: BGH3_people Q15582 transforming growth factor-beta induced protein 5 6 other sw: TGLC_People P21980 tissue transglutaminase 2 54 sw: KPY1_People P14618 Human pyruvate kinase, cytoplasmic thyroid hormone-binding protein 3 68 Humangp: CHR19-Q96D15 Q96D15 Reticulin 3 precursor 2 69

Sequence Listing

<110> Beijing Nuosai Genome Research Center Co., Ltd.

<120>Specific markers of pancreatic cancer

<130>SGF-01-1117

<160>110

<170>PatentIn version 3.2

<210>1

<211>412

<212>PRT

<213> Human (Homo sapiens)

<220>

<221> histone D precursor

<222>(1)..(412)

<223> December 6, 2002 Registration number: P07339

<400>1

Met Gln Pro Ser Ser Leu Leu Pro Leu Ala Leu Cys Leu Leu Ala Ala

1 5 10 15

Pro Ala Ser Ala Leu Val Arg Ile Pro Leu His Lys Phe Thr Ser Ile

20 25 30

Arg Arg Thr Met Ser Glu Val Gly Gly Ser Val Glu Asp Leu Ile Ala

35 40 45

Lys Gly Pro Val Ser Lys Tyr Ser Gln Ala Val Pro Ala Val Thr Glu

50 55 60

Gly Pro Ile Pro Glu Val Leu Lys Asn Tyr Met Asp Ala Gln Tyr Tyr

65 70 75 80

Gly Glu Ile Gly Ile Gly Thr Pro Pro Gln Cys Phe Thr Val Val Phe

85 90 95

Asp Thr Gly Ser Ser Asn Leu Trp Val Pro Ser Ile His Cys Lys Leu

100 105 110

Leu Asp Ile Ala Cys Trp Ile His His Lys Tyr Asn Ser Asp Lys Ser

115 120 125

Ser Thr Tyr Val Lys Asn Gly Thr Ser Phe Asp Ile His Tyr Gly Ser

130 135 140

Gly Ser Leu Ser Gly Tyr Leu Ser Gln Asp Thr Val Ser Val Pro Cys

145 150 155 160

Gln Ser Ala Ser Ser Ala Ser Ala Leu Gly Gly Val Lys Val Glu Arg

165 170 175

Gln Val Phe Gly Glu Ala Thr Lys Gln Pro Gly Ile Thr Phe Ile Ala

180 185 190

Ala Lys Phe Asp Gly Ile Leu Gly Met Ala Tyr Pro Arg Ile Ser Val

195 200 205

Asn Asn Val Leu Pro Val Phe Asp Asn Leu Met Gln Gln Lys Leu Val

210 215 220

Asp Gln Asn Ile Phe Ser Phe Tyr Leu Ser Arg Asp Pro Asp Ala Gln

225 230 235 240

Pro Gly Gly Glu Leu Met Leu Gly Gly Thr Asp Ser Lys Tyr Tyr Lys

245 250 255

Gly Ser Leu Ser Tyr Leu Asn Val Thr Arg Lys Ala Tyr Trp Gln Val

260 265 270

His Leu Asp Gln Val Glu Val Ala Ser Gly Leu Thr Leu Cys Lys Glu

275 280 285

Gly Cys Glu Ala Ile Val Asp Thr Gly Thr Ser Leu Met Val Gly Pro

290 295 300

Val Asp Glu Val Arg Glu Leu Gln Lys Ala Ile Gly Ala Val Pro Leu

305 310 315 320

Ile Gln Gly Glu Tyr Met Ile Pro Cys Glu Lys Val Ser Thr Leu Pro

325 330 335

Ala Ile Thr Leu Lys Leu Gly Gly Lys Gly Tyr Lys Leu Ser Pro Glu

340 345 350

Asp Tyr Thr Leu Lys Val Ser Gln Ala Gly Lys Thr Leu Cys Leu Ser

355 360 365

Gly Phe Met Gly Met Asp Ile Pro Pro Pro Ser Gly Pro Leu Trp Ile

370 375 380

Leu Gly Asp Val Phe Ile Gly Arg Tyr Tyr Thr Val Phe Asp Arg Asp

385 390 395 400

Asn Asn Arg Val Gly Phe Ala Glu Ala Ala Arg Leu

405 410

<210>2

<211>414

<212>PRT

<213> Human (Homo sapiens)

<220>

<221> Cytoplasmic isocitrate dehydrogenase [NADP]

<222>(1)..(414)

<223> December 6, 2002 Registration number: 075874

<400>2

Met Ser Lys Lys Ile Ser Gly Gly Ser Val Val Glu Met Gln Gly Asp

1 5 10 15

Glu Met Thr Arg Ile Ile Trp Glu Leu Ile Lys Glu Lys Leu Ile Phe

20 25 30

Pro Tyr Val Glu Leu Asp Leu His Ser Tyr Asp Leu Gly Ile Glu Asn

35 40 45

Arg Asp Ala Thr Asn Asp Gln Val Thr Lys Asp Ala Ala Glu Ala Ile

50 55 60

Lys Lys His Asn Val Gly Val Lys Cys Ala Thr Ile Thr Pro Asp Glu

65 70 75 80

Lys Arg Val Glu Glu Phe Lys Leu Lys Gln Met Trp Lys Ser Pro Asn

85 90 95

Gly Thr Ile Arg Asn Ile Leu Gly Gly Thr Val Phe Arg Glu Ala Ile

100 105 110

Ile Cys Lys Asn Ile Pro Arg Leu Val Ser Gly Trp Val Lys Pro Ile

115 120 125

Ile Ile Gly Arg His Ala Tyr Gly Asp Gln Tyr Arg Ala Thr Asp Phe

130 135 140

Val Val Pro Gly Pro Gly Lys Val Glu Ile Thr Tyr Thr Pro Ser Asp

145 150 155 160

Gly Thr Gln Lys Val Thr Tyr Leu Val His Asn Phe Glu Glu Gly Gly

165 170 175

Gly Val Ala Met Gly Met Tyr Asn Gln Asp Lys Ser Ile Glu Asp Phe

180 185 190

Ala His Ser Ser Phe Gln Met Ala Leu Ser Lys Gly Trp Pro Leu Tyr

195 200 205

Leu Ser Thr Lys Asn Thr Ile Leu Lys Lys Tyr Asp Gly Arg Phe Lys

210 215 220

Asp Ile Phe Gln Glu Ile Tyr Asp Lys Gln Tyr Lys Ser Gln Phe Glu

225 230 235 240

Ala Gln Lys Ile Trp Tyr Glu His Arg Leu Ile Asp Asp Met Val Ala

245 250 255

Gln Ala Met Lys Ser Glu Gly Gly Phe Ile Trp Ala Cys Lys Asn Tyr

260 265 270

Asp Gly Asp Val Gln Ser Asp Ser Val Ala Gln Gly Tyr Gly Ser Leu

275 280 285

Gly Met Met Thr Ser Val Leu Val Cys Pro Asp Gly Lys Thr Val Glu

290 295 300

Ala Glu Ala Ala His Gly Thr Val Thr Arg His Tyr Arg Met Tyr Gln

305 310 315 320

Lys Gly Gln Glu Thr Ser Thr Asn Pro Ile Ala Ser Ile Phe Ala Trp

325 330 335

Thr Arg Gly Leu Ala His Arg Ala Lys Leu Asp Asn Asn Lys Glu Leu

340 345 350

Ala Phe Phe Ala Asn Ala Leu Glu Glu Val Ser Ile Glu Thr Ile Glu

355 360 365

Ala Gly Phe Met Thr Lys Asp Leu Ala Ala Cys Ile Lys Gly Leu Pro

370 375 380

Asn Val Gln Arg Ser Asp Tyr Leu Asn Thr Phe Glu Phe Met Asp Lys

385 390 395 400

Leu Gly Glu Asn Leu Lys Ile Lys Leu Ala Gln Ala Lys Leu

405 410

<210>3

<211>782

<212>PRT

<213> Human (Homo sapiens)

<220>

<221> Plasma gelsolin precursor

<222>(1)..(782)

<223> December 6, 2002 Registration number: P06396

<400>3

Met Ala Pro His Arg Pro Ala Pro Ala Leu Leu Cys Ala Leu Ser Leu

1 5 10 15

Ala Leu Cys Ala Leu Ser Leu Pro Val Arg Ala Ala Thr Ala Ser Arg

20 25 30

Gly Ala Ser Gln Ala Gly Ala Pro Gln Gly Arg Val Pro Glu Ala Arg

35 40 45

Pro Asn Ser Met Val Val Glu His Pro Glu Phe Leu Lys Ala Gly Lys

50 55 60

Glu Pro Gly Leu Gln Ile Trp Arg Val Glu Lys Phe Asp Leu Val Pro

65 70 75 80

Val Pro Thr Asn Leu Tyr Gly Asp Phe Phe Thr Gly Asp Ala Tyr Val

85 90 95

Ile Leu Lys Thr Val Gln Leu Arg Asn Gly Asn Leu Gln Tyr Asp Leu

100 105 110

His Tyr Trp Leu Gly Asn Glu Cys Ser Gln Asp Glu Ser Gly Ala Ala

115 120 125

Ala Ile Phe Thr Val Gln Leu Asp Asp Tyr Leu Asn Gly Arg Ala Val

130 135 140

Gln His Arg Glu Val Gln Gly Phe Glu Ser Ala Thr Phe Leu Gly Tyr

145 150 155 160

Phe Lys Ser Gly Leu Lys Tyr Lys Lys Gly Gly Val Ala Ser Gly Phe

165 170 175

Lys His Val Val Pro Asn Glu Val Val Val Gln Arg Leu Phe Gln Val

180 185 190

Lys Gly Arg Arg Val Val Arg Ala Thr Glu Val Pro Val Ser Trp Glu

195 200 205

Ser Phe Asn Asn Gly Asp Cys Phe Ile Leu Asp Leu Gly Asn Asn Ile

210 215 220

His Gln Trp Cys Gly Ser Asn Ser Asn Arg Tyr Glu Arg Leu Lys Ala

225 230 235 240

Thr Gln Val Ser Lys Gly Ile Arg Asp Asn Glu Arg Ser Gly Arg Ala

245 250 255

Arg Val His Val Ser Glu Glu Gly Thr Glu Pro Glu Ala Met Leu Gln

260 265 270

Val Leu Gly Pro Lys Pro Ala Leu Pro Ala Gly Thr Glu Asp Thr Ala

275 280 285

Lys Glu Asp Ala Ala Asn Arg Lys Leu Ala Lys Leu Tyr Lys Val Ser

290 295 300

Asn Gly Ala Gly Thr Met Ser Val Ser Leu Val Ala Asp Glu Asn Pro

305 310 315 320

Phe Ala Gln Gly Ala Leu Lys Ser Glu Asp Cys Phe Ile Leu Asp His

325 330 335

Gly Lys Asp Gly Lys Ile Phe Val Trp Lys Gly Lys Gln Ala Asn Thr

340 345 350

Glu Glu Arg Lys Ala Ala Leu Lys Thr Ala Ser Asp Phe Ile Thr Lys

355 360 365

Met Asp Tyr Pro Lys Gln Thr Gln Val Ser Val Leu Pro Glu Gly Gly

370 375 380

Glu Thr Pro Leu Phe Lys Gln Phe Phe Lys Asn Trp Arg Asp Pro Asp

385 390 395 400

Gln Thr Asp Gly Leu Gly Leu Ser Tyr Leu Ser Ser His Ile Ala Asn

405 410 415

Val Glu Arg Val Pro Phe Asp Ala Ala Thr Leu His Thr Ser Thr Ala

420 425 430

Met Ala Ala Gln His Gly Met Asp Asp Asp Gly Thr Gly Gln Lys Gln

435 440 445

Ile Trp Arg Ile Glu Gly Ser Asn Lys Val Pro Val Asp Pro Ala Thr

450 455 460

Tyr Gly Gln Phe Tyr Gly Gly Asp Ser Tyr Ile Ile Leu Tyr Asn Tyr

465 470 475 480

Arg His Gly Gly Arg Gln Gly Gln Ile Ile Tyr Asn Trp Gln Gly Ala

485 490 495

Gln Ser Thr Gln Asp Glu Val Ala Ala Ser Ala Ile Leu Thr Ala Gln

500 505 510

Leu Asp Glu Glu Leu Gly Gly Thr Pro Val Gln Ser Arg Val Val Gln

515 520 525

Gly Lys Glu Pro Ala His Leu Met Ser Leu Phe Gly Gly Lys Pro Met

530 535 540

Ile Ile Tyr Lys Gly Gly Thr Ser Arg Glu Gly Gly Gln Thr Ala Pro

545 550 555 560

Ala Ser Thr Arg Leu Phe Gln Val Arg Ala Asn Ser Ala Gly Ala Thr

565 570 575

Arg Ala Val Glu Val Leu Pro Lys Ala Gly Ala Leu Asn Ser Asn Asp

580 585 590

Ala Phe Val Leu Lys Thr Pro Ser Ala Ala Tyr Leu Trp Val Gly Thr

595 600 605

Gly Ala Ser Glu Ala Glu Lys Thr Gly Ala Gln Glu Leu Leu Arg Val

610 615 620

Leu Arg Ala Gln Pro Val Gln Val Ala Glu Gly Ser Ser Glu Pro Asp Gly

625 630 635 640

Phe Trp Glu Ala Leu Gly Gly Lys Ala Ala Tyr Arg Thr Ser Pro Arg

645 650 655

Leu Lys Asp Lys Lys Met Asp Ala His Pro Pro Arg Leu Phe Ala Cys

660 665 670

Ser Asn Lys Ile Gly Arg Phe Val Ile Glu Glu Val Pro Gly Glu Leu

675 680 685

Met Gln Glu Asp Leu Ala Thr Asp Asp Val Met Leu Leu Asp Thr Trp

690 695 700

Asp Gln Val Phe Val Trp Val Gly Lys Asp Ser Gln Glu Glu Glu Lys

705 710 715 720

Thr Glu Ala Leu Thr Ser Ala Lys Arg Tyr Ile Glu Thr Asp Pro Ala

725 730 735

Asn Arg Asp Arg Arg Thr Pro Ile Thr Val Val Lys Gln Gly Phe Glu

740 745 750

Pro Pro Ser Phe Val Gly Trp Phe Leu Gly Trp Asp Asp Asp Tyr Trp

755 760 765

Ser Val Asp Pro Leu Asp Arg Ala Met Ala Glu Leu Ala Ala

770 775 780

<210>4

<211>764

<212>PRT

<213> Human (Homo sapiens)

<220>

<221> Complement factor B precursor

<222>(1)..(764)

<223> December 6, 2002 Registration number: P00751

<400>4

Met Gly Ser Asn Leu Ser Pro Gln Leu Cys Leu Met Pro Phe Ile Leu

1 5 10 15

Gly Leu Leu Ser Gly Gly Val Thr Thr Thr Pro Trp Ser Leu Ala Arg

20 25 30

Pro Gln Gly Ser Cys Ser Leu Glu Gly Val Glu Ile Lys Gly Gly Ser

35 40 45

Phe Arg Leu Leu Gln Glu Gly Gln Ala Leu Glu Tyr Val Cys Pro Ser

50 55 60

Gly Phe Tyr Pro Tyr Pro Val Gln Thr Arg Thr Cys Arg Ser Thr Gly

65 70 75 80

Ser Trp Ser Thr Leu Lys Thr Gln Asp Gln Lys Thr Val Arg Lys Ala

85 90 95

Glu Cys Arg Ala Ile His Cys Pro Arg Pro His Asp Phe Glu Asn Gly

100 105 110

Glu Tyr Trp Pro Arg Ser Pro Tyr Tyr Asn Val Ser Asp Glu Ile Ser

115 120 125

Phe His Cys Tyr Asp Gly Tyr Thr Leu Arg Gly Ser Ala Asn Arg Thr

130 135 140

Cys Gln Val Asn Gly Arg Trp Ser Gly Gln Thr Ala Ile Cys Asp Asn

145 150 155 160

Gly Ala Gly Tyr Cys Ser Asn Pro Gly Ile Pro Ile Gly Thr Arg Lys

165 170 175

Val Gly Ser Gln Tyr Arg Leu Glu Asp Ser Val Thr Tyr His Cys Ser

180 185 190

Arg Gly Leu Thr Leu Arg Gly Ser Gln Arg Arg Thr Cys Gln Glu Gly

195 200 205

Gly Ser Trp Ser Gly Thr Glu Pro Ser Cys Gln Asp Ser Phe Met Tyr

210 215 220

Asp Thr Pro Gln Glu Val Ala Glu Ala Phe Leu Ser Ser Leu Thr Glu

225 230 235 240

Thr Ile Glu Gly Val Asp Ala Glu Asp Gly His Gly Pro Gly Glu Gln

245 250 255

Gln Lys Arg Lys Ile Val Leu Asp Pro Ser Gly Ser Met Asn Ile Tyr

260 265 270

Leu Val Leu Asp Gly Ser Asp Ser Ile Gly Ala Ser Asn Phe Thr Gly

275 280 285

Ala Lys Lys Cys Leu Val Asn Leu Ile Glu Lys Val Ala Ser Tyr Gly

290 295 300

Val Lys Pro Arg Tyr Gly Leu Val Thr Tyr Ala Thr Tyr Pro Lys Ile

305 310 315 320

Trp Val Lys Val Ser Glu Ala Asp Ser Ser Ser Asn Ala Asp Trp Val Thr

325 330 335

Lys Gln Leu Asn Glu Ile Asn Tyr Glu Asp His Lys Leu Lys Ser Gly

340 345 350

Thr Asn Thr Lys Lys Ala Leu Gln Ala Val Tyr Ser Met Met Ser Trp

355 360 365

Pro Asp Asp Val Pro Pro Glu Gly Trp Asn Arg Thr Arg His Val Ile

370 375 380

Ile Leu Met Thr Asp Gly Leu His Asn Met Gly Gly Asp Pro Ile Thr

385 390 395 400

Val Ile Asp Glu Ile Arg Asp Leu Leu Tyr Ile Gly Lys Asp Arg Lys

405 410 415

Asn Pro Arg Glu Asp Tyr Leu Asp Val Tyr Val Phe Gly Val Gly Pro

420 425 430

Leu Val Asn Gln Val Asn Ile Asn Ala Leu Ala Ser Lys Lys Asp Asn

435 440 445

Glu Gln His Val Phe Lys Val Lys Asp Met Glu Asn Leu Glu Asp Val

450 455 460

Phe Tyr Gln Met Ile Asp Glu Ser Gln Ser Leu Ser Leu Cys Gly Met

465 470 475 480

Val Trp Glu His Arg Lys Gly Thr Asp Tyr His Lys Gln Pro Trp Gln

485 490 495

Ala Lys Ile Ser Val Ile Arg Pro Ser Lys Gly His Glu Ser Cys Met

500 505 510

Gly Ala Val Val Ser Glu Tyr Phe Val Leu Thr Ala Ala His Cys Phe

515 520 525

Thr Val Asp Asp Lys Glu His Ser Ile Lys Val Ser Val Gly Gly Glu

530 535 540

Lys Arg Asp Leu Glu Ile Glu Val Val Leu Phe His Pro Asn Tyr Asn

545 550 555 560

Ile Asn Gly Lys Lys Glu Ala Gly Ile Pro Glu Phe Tyr Asp Tyr Asp

565 570 575

Val Ala Leu Ile Lys Leu Lys Asn Lys Leu Lys Tyr Gly Gln Thr Ile

580 585 590

Arg Pro Ile Cys Leu Pro Cys Thr Glu Gly Thr Thr Arg Ala Leu Arg

595 600 605

Leu Pro Pro Thr Thr Thr Cys Gln Gln Gln Lys Glu Glu Leu Leu Pro

610 615 620

Ala Gln Asp Ile Lys Ala Leu Phe Val Ser Glu Glu Lys Lys Leu

625 630 635 640

Thr Arg Lys Glu Val Tyr Ile Lys Asn Gly Asp Lys Lys Gly Ser Cys

645 650 655

Glu Arg Asp Ala Gln Tyr Ala Pro Gly Tyr Asp Lys Val Lys Asp Ile

660 665 670

Ser Glu Val Val Thr Pro Arg Phe Leu Cys Thr Gly Gly Val Ser Pro

675 680 685

Tyr Ala Asp Pro Asn Thr Cys Arg Gly Asp Ser Gly Gly Pro Leu Ile

690 695 700

Val His Lys Arg Ser Arg Phe Ile Gln Val Gly Val Ile Ser Trp Gly

705 710 715 720

Val Val Asp Val Cys Lys Asn Gln Lys Arg Gln Lys Gln Val Pro Ala

725 730 735

His Ala Arg Asp Phe His Ile Asn Leu Phe Gln Val Leu Pro Trp Leu

740 745 750

Lys Glu Lys Leu Gln Asp Glu Asp Leu Gly Phe Leu

755 760

<210>5

<211>911

<212>PRT

<213> Human (Homo sapiens)

<220>

<221> Alpha-actinin 4

<222>(1)..(911)

<223> Registration Number: 043707

<400>5

Met Val Asp Tyr His Ala Ala Asn Gln Ser Tyr Gln Tyr Gly Pro Ser

1 5 10 15

Ser Ala Gly Asn Gly Ala Gly Gly Gly Gly Ser Met Gly Asp Tyr Met

20 25 30

Ala Gln Glu Asp Asp Trp Asp Arg Asp Leu Leu Leu Asp Pro Ala Trp

35 40 45

Glu Lys Gln Gln Arg Lys Thr Phe Thr Ala Trp Cys Asn Ser His Leu

50 55 60

Arg Lys Ala Gly Thr Gln Ile Glu Asn Ile Asp Glu Asp Phe Arg Asp

65 70 75 80

Gly Leu Lys Leu Met Leu Leu Leu Glu Val Ile Ser Gly Glu Arg Leu

85 90 95

Pro Lys Pro Glu Arg Gly Lys Met Arg Val His Lys Ile Asn Asn Val

100 105 110

Asn Lys Ala Leu Asp Phe Ile Ala Ser Lys Gly Val Lys Leu Val Ser

115 120 125

Ile Gly Ala Glu Glu Ile Val Asp Gly Asn Ala Lys Met Thr Leu Gly

130 135 140

Met Ile Trp Thr Ile Ile Leu Arg Phe Ala Ile Gln Asp Ile Ser Val

145 150 155 160

Glu Glu Thr Ser Ala Lys Glu Gly Leu Leu Leu Trp Cys Gln Arg Lys

165 170 175

Thr Ala Pro Tyr Lys Asn Val Asn Val Gln Asn Phe His Ile Ser Trp

180 185 190

Lys Asp Gly Leu Ala Phe Asn Ala Leu Ile His Arg His Arg Pro Glu

195 200 205

Leu Ile Glu Tyr Asp Lys Leu Arg Lys Asp Asp Pro Val Thr Asn Leu

210 215 220

Asn Asn Ala Phe Glu Val Ala Glu Lys Tyr Leu Asp Ile Pro Lys Met

225 230 235 240

Leu Asp Ala Glu Asp Ile Val Asn Thr Ala Arg Pro Asp Glu Lys Ala

245 250 255

Ile Met Thr Tyr Val Ser Ser Phe Tyr His Ala Phe Ser Gly Ala Gln

260 265 270

Lys Ala Glu Thr Ala Ala Asn Arg Ile Cys Lys Val Leu Ala Val Asn

275 280 285

Gln Glu Asn Glu His Leu Met Glu Asp Tyr Glu Lys Leu Ala Ser Asp

290 295 300

Leu Leu Glu Trp Ile Arg Arg Thr Ile Pro Trp Leu Glu Asp Arg Val

305 310 315 320

Pro Gln Lys Thr Ile Gln Glu Met Gln Gln Lys Leu Glu Asp Phe Arg

325 330 335

Asp Tyr Arg Arg Val His Lys Pro Pro Lys Val Gln Glu Lys Cys Gln

340 345 350

Leu Glu Ile Asn Phe Asn Thr Leu Gln Thr Lys Leu Arg Leu Ser Asn

355 360 365

Arg Pro Ala Phe Met Pro Ser Glu Gly Lys Met Val Ser Asp Ile Asn

370 375 380

Asn Gly Trp Gln His Leu Glu Gln Ala Glu Lys Gly Tyr Glu Glu Trp

385 390 395 400

Leu Leu Asn Glu Ile Arg Arg Leu Glu Arg Leu Asp His Leu Ala Glu

405 410 415

Lys Phe Arg Gln Lys Ala Ser Ile His Glu Ala Trp Thr Asp Gly Lys

420 425 430

Glu Ala Met Leu Lys His Arg Asp Tyr Glu Thr Ala Thr Leu Ser Asp

435 440 445

Ile Lys Ala Leu Ile Arg Lys His Glu Ala Phe Glu Ser Asp Leu Ala

450 455 460

Ala His Gln Asp Arg Val Glu Gln Ile Ala Ala Ile Ala Gln Glu Leu

465 470 475 480

Asn Glu Leu Asp Tyr Tyr Asp Ser His Asn Val Asn Thr Arg Cys Gln

485 490 495

Lys Ile Cys Asp Gln Trp Asp Ala Leu Gly Ser Leu Thr His Ser Arg

500 505 510

Arg Glu Ala Leu Glu Lys Thr Glu Lys Gln Leu Glu Ala Ile Asp Gln

515 520 525

Leu His Leu Glu Tyr Ala Lys Arg Ala Ala Pro Phe Asn Asn Trp Met

530 535 540

Glu Ser Ala Met Glu Asp Leu Gln Asp Met Phe Ile Val His Thr Ile

545 550 555 560

Glu Glu Ile Glu Gly Leu Ile Ser Ala His Asp Gln Phe Lys Ser Thr

565 570 575

Leu Pro Asp Ala Asp Arg Glu Arg Glu Ala Ile Leu Ala Ile His Lys

580 585 590

Glu Ala Gln Arg Ile Ala Glu Ser Asn His Ile Lys Leu Ser Gly Ser

595 600 605

Asn Pro Tyr Thr Thr Val Thr Pro Gln Ile Ile Asn Ser Lys Trp Glu

610 615 620

Lys Val Gln Gln Leu Val Pro Lys Arg Asp His Ala Leu Leu Glu Glu

625 630 635 640

Gln Ser Lys Gln Gln Ser Asn Glu His Leu Arg Arg Gln Phe Ala Ser

645 650 655

Gln Ala Asn Val Val Gly Pro Trp Ile Gln Thr Lys Met Glu Glu Ile

660 665 670

Gly Arg Ile Ser Ile Glu Met Asn Gly Thr Leu Glu Asp Gln Leu Ser

675 680 685

His Leu Lys Gln Tyr Glu Arg Ser Ile Val Asp Tyr Lys Pro Asn Leu

690 695 700

Asp Leu Leu Glu Gln Gln His Gln Leu Ile Gln Glu Ala Leu Ile Phe

705 710 715 720

Asp Asn Lys His Thr Asn Tyr Thr Met Glu His Ile Arg Val Gly Trp

725 730 735

Glu Gln Leu Leu Thr Thr Ile Ala Arg Thr Ile Asn Glu Val Glu Asn

740 745 750

Gln Ile Leu Thr Arg Asp Ala Lys Gly Ile Ser Gln Glu Gln Met Gln

755 760 765

Glu Phe Arg Ala Ser Phe Asn His Phe Asp Lys Asp His Gly Gly Ala

770 775 780

Leu Gly Pro Glu Glu Phe Lys Ala Cys Leu Ile Ser Leu Gly Tyr Asp

785 790 795 800

Val Glu Asn Asp Arg Gln Gly Glu Ala Glu Phe Asn Arg Ile Met Ser

805 810 815

Leu Val Asp Pro Asn His Ser Gly Leu Val Thr Phe Gln Ala Phe Ile

820 825 830

Asp Phe Met Ser Arg Glu Thr Thr Asp Thr Asp Thr Ala Asp Gln Val

835 840 845

Ile Ala Ser Phe Lys Val Leu Ala Gly Asp Lys Asn Phe Ile Thr Ala

850 855 860

Glu Glu Leu Arg Arg Glu Leu Pro Pro Asp Gln Ala Glu Tyr Cys Ile

865 870 875 880

Ala Arg Met Ala Pro Tyr Gln Gly Pro Asp Ala Val Pro Gly Ala Leu

885 890 895

Asp Tyr Lys Ser Phe Ser Thr Ala Leu Tyr Gly Glu Ser Asp Leu

900 905 910

<210>6

<211>683

<212>PRT

<213> Human (Homo sapiens)

<220>

<221> Transforming growth factor beta-induced protein IG-H3 precursor

<222>(1)..(683)

<223> December 6, 2002 Registration number: Q15582

<400>6

Met Ala Leu Phe Val Arg Leu Leu Ala Leu Ala Leu Ala Leu Ala Leu

1 5 10 15

Gly Pro Ala Ala Thr Leu Ala Gly Pro Ala Lys Ser Pro Tyr Gln Leu

20 25 30

Val Leu Gln His Ser Arg Leu Arg Gly Arg Gln His Gly Pro Asn Val

35 40 45

Cys Ala Val Gln Lys Val Ile Gly Thr Asn Arg Lys Tyr Phe Thr Asn

50 55 60

Cys Lys Gln Trp Tyr Gln Arg Lys Ile Cys Gly Lys Ser Thr Val Ile

65 70 75 80

Ser Tyr Glu Cys Cys Pro Gly Tyr Glu Lys Val Pro Gly Glu Lys Gly

85 90 95

Cys Pro Ala Ala Leu Pro Leu Ser Asn Leu Tyr Glu Thr Leu Gly Val

100 105 110

Val Gly Ser Thr Thr Thr Gln Leu Tyr Thr Asp Arg Thr Glu Lys Leu

115 120 125

Arg Pro Glu Met Glu Gly Pro Gly Ser Phe Thr Ile Phe Ala Pro Ser

130 135 140

Asn Glu Ala Trp Ala Ser Leu Pro Ala Glu Val Leu Asp Ser Leu Val

145 150 155 160

Ser Asn Val Asn Ile Glu Leu Leu Asn Ala Leu Arg Tyr His Met Val

165 170 175

Gly Arg Arg Val Leu Thr Asp Glu Leu Lys His Gly Met Thr Leu Thr

180 185 190

Ser Met Tyr Gln Asn Ser Asn Ile Gln Ile His His Tyr Pro Asn Gly

195 200 205

Ile Val Thr Val Asn Cys Ala Arg Leu Leu Lys Ala Asp His His Ala

210 215 220

Thr Asn Gly Val Val His Leu Ile Asp Lys Val Ile Ser Thr Ile Thr

225 230 235 240

Asn Asn Ile Gln Gln Ile Ile Glu Ile Glu Asp Thr Phe Glu Thr Leu

245 250 255

Arg Ala Ala Val Ala Ala Ser Gly Leu Asn Thr Met Leu Glu Gly Asn

260 265 270

Gly Gln Tyr Thr Leu Leu Ala Pro Thr Asn Glu Ala Phe Glu Lys Ile

275 280 285

Pro Ser Glu Thr Leu Asn Arg Ile Leu Gly Asp Pro Glu Ala Leu Arg

290 295 300

Asp Leu Leu Asn Asn His Ile Leu Lys Ser Ala Met Cys Ala Glu Ala

305 310 315 320

Ile Val Ala Gly Leu Ser Val Glu Thr Leu Glu Gly Thr Thr Leu Glu

325 330 335

Val Gly Cys Ser Gly Asp Met Leu Thr Ile Asn Gly Lys Ala Ile Ile

340 345 350

Ser Asn Lys Asp Ile Leu Ala Thr Asn Gly Val Ile His Tyr Ile Asp

355 360 365

Glu Leu Leu Ile Pro Asp Ser Ala Lys Thr Leu Phe Glu Leu Ala Ala

370 375 380

Glu Ser Asp Val Ser Thr Ala Ile Asp Leu Phe Arg Gln Ala Gly Leu

385 390 395 400

Gly Asn His Leu Ser Gly Ser Glu Arg Leu Thr Leu Leu Ala Pro Leu

405 410 415

Asn Ser Val Phe Lys Asp Gly Thr Pro Pro Ile Asp Ala His Thr Arg

420 425 430

Asn Leu Leu Arg Asn His Ile Ile Lys Asp Gln Leu Ala Ser Lys Tyr

435 440 445

Leu Tyr His Gly Gln Thr Leu Glu Thr Leu Gly Gly Lys Lys Leu Arg

450 455 460

Val Phe Val Tyr Arg Asn Ser Leu Cys Ile Glu Asn Ser Cys Ile Ala

465 470 475 480

Ala His Asp Lys Arg Gly Arg Tyr Gly Thr Leu Phe Thr Met Asp Arg

485 490 495

Val Leu Thr Pro Pro Met Gly Thr Val Met Asp Val Leu Lys Gly Asp

500 505 510

Asn Arg Phe Ser Met Leu Val Ala Ala Ile Gln Ser Ala Gly Leu Thr

515 520 525

Glu Thr Leu Asn Arg Glu Gly Val Tyr Thr Val Phe Ala Pro Thr Asn

530 535 540

Glu Ala Phe Arg Ala Leu Pro Pro Arg Glu Arg Ser Arg Leu Leu Gly

545 550 555 560

Asp Ala Lys Glu Leu Ala Asn Ile Leu Lys Tyr His Ile Gly Asp Glu

565 570 575

Ile Leu Val Ser Gly Gly Ile Gly Ala Leu Val Arg Leu Lys Ser Leu

580 585 590

Gln Gly Asp Lys Leu Glu Val Ser Leu Lys Asn Asn Val Val Ser Val

595 600 605

Asn Lys Glu Pro Val Ala Glu Pro Asp Ile Met Ala Thr Asn Gly Val

610 615 620

Val His Val Ile Thr Asn Val Leu Gln Pro Pro Ala Asn Arg Pro Gln

625 630 635 640

Glu Arg Gly Asp Glu Leu Ala Asp Ser Ala Leu Glu Ile Phe Lys Gln

645 650 655

Ala Ser Ala Phe Ser Arg Ala Ser Gln Arg Ser Val Arg Leu Ala Pro

660 665 670

Val Tyr Gln Lys Leu Leu Glu Arg Met Lys His

675 680

<210>7

<211>892

<212>PRT

<213> Human (Homo sapiens)

<220>

<221> Alpha-actinin 1

<222>(1)..(892)

<223> Registration Number: P12814

<400>7

Met Asp His Tyr Asp Ser Gln Gln Thr Asn Asp Tyr Met Gln Pro Glu

1 5 10 15

Glu Asp Trp Asp Arg Asp Leu Leu Leu Asp Pro Ala Trp Glu Lys Gln

20 25 30

Gln Arg Lys Thr Phe Thr Ala Trp Cys Asn Ser His Leu Arg Lys Ala

35 40 45

Gly Thr Gln Ile Glu Asn Ile Glu Glu Asp Phe Arg Asp Gly Leu Lys

50 55 60

Leu Met Leu Leu Leu Glu Val Ile Ser Gly Glu Arg Leu Ala Lys Pro

65 70 75 80

Glu Arg Gly Lys Met Arg Val His Lys Ile Ser Asn Val Asn Lys Ala

85 90 95

Leu Asp Phe Ile Ala Ser Lys Gly Val Lys Leu Val Ser Ile Gly Ala

100 105 110

Glu Glu Ile Val Asp Gly Asn Val Lys Met Thr Leu Gly Met Ile Trp

115 120 125

Thr Ile Ile Leu Arg Phe Ala Ile Gln Asp Ile Ser Val Glu Glu Thr

130 135 140

Ser Ala Lys Glu Gly Leu Leu Leu Trp Cys Gln Arg Lys Thr Ala Pro

145 150 155 160

Tyr Lys Asn Val Asn Ile Gln Asn Phe His Ile Ser Trp Lys Asp Gly

165 170 175

Leu Gly Phe Cys Ala Leu Ile His Arg His Arg Pro Glu Leu Ile Asp

180 185 190

Tyr Gly Lys Leu Arg Lys Asp Asp Pro Leu Thr Asn Leu Asn Thr Ala

195 200 205

Phe Asp Val Ala Glu Lys Tyr Leu Asp Ile Pro Lys Met Leu Asp Ala

210 215 220

Glu Asp Ile Val Gly Thr Ala Arg Pro Asp Glu Lys Ala Ile Met Thr

225 230 235 240

Tyr Val Ser Ser Phe Tyr His Ala Phe Ser Gly Ala Gln Lys Ala Glu

245 250 255

Thr Ala Ala Asn Arg Ile Cys Lys Val Leu Ala Val Asn Gln Glu Asn

260 265 270

Glu Gln Leu Met Glu Asp Tyr Glu Lys Leu Ala Ser Asp Leu Leu Glu

275 280 285

Trp Ile Arg Arg Thr Ile Pro Trp Leu Glu Asn Arg Val Pro Glu Asn

290 295 300

Thr Met His Ala Met Gln Gln Lys Leu Glu Asp Phe Arg Asp Tyr Arg

305 310 315 320

Arg Leu His Lys Pro Pro Lys Val Gln Glu Lys Cys Gln Leu Glu Ile

325 330 335

Asn Phe Asn Thr Leu Gln Thr Lys Leu Arg Leu Ser Asn Arg Pro Ala

340 345 350

Phe Met Pro Ser Glu Gly Arg Met Val Ser Asp Ile Asn Asn Ala Trp

355 360 365

Gly Cys Leu Glu Gln Val Glu Lys Gly Tyr Glu Glu Trp Leu Leu Asn

370 375 380

Glu Ile Arg Arg Leu Glu Arg Leu Asp His Leu Ala Glu Lys Phe Arg

385 390 395 400

Gln Lys Ala Ser Ile His Glu Ala Trp Thr Asp Gly Lys Glu Ala Met

405 410 415

Leu Arg Gln Lys Asp Tyr Glu Thr Ala Thr Leu Ser Glu Ile Lys Ala

420 425 430

Leu Leu Lys Lys His Glu Ala Phe Glu Ser Asp Leu Ala Ala His Gln

435 440 445

Asp Arg Val Glu Gln Ile Ala Ala Ile Ala Gln Glu Leu Asn Glu Leu

450 455 460

Asp Tyr Tyr Asp Ser Pro Ser Val Asn Ala Arg Cys Gln Lys Ile Cys

465 470 475 480

Asp Gln Trp Asp Asn Leu Gly Ala Leu Thr Gln Lys Arg Arg Glu Ala

485 490 495

Leu Glu Arg Thr Glu Lys Leu Leu Glu Thr Ile Asp Gln Leu Tyr Leu

500 505 510

Glu Tyr Ala Lys Arg Ala Ala Pro Phe Asn Asn Trp Met Glu Gly Ala

515 520 525

Met Glu Asp Leu Gln Asp Thr Phe Ile Val His Thr Ile Glu Glu Ile

530 535 540

Gln Gly Leu Thr Thr Ala His Glu Gln Phe Lys Ala Thr Leu Pro Asp

545 550 555 560

Ala Asp Lys Glu Arg Leu Ala Ile Leu Gly Ile His Asn Glu Val Ser

565 570 575

Lys Ile Val Gln Thr Tyr His Val Asn Met Ala Gly Thr Asn Pro Tyr

580 585 590

Thr Thr Ile Thr Pro Gln Glu Ile Asn Gly Lys Trp Asp His Val Arg

595 600 605

Gln Leu Val Pro Arg Arg Asp Gln Ala Leu Thr Glu Glu His Ala Arg

610 615 620

Gln Gln His Asn Glu Ser Val Arg Lys Gln Phe Gly Ala Gln Ala Asn

625 630 635 640

Val Ile Gly Pro Trp Ile Gln Thr Lys Met Glu Glu Ile Gly Arg Ile

645 650 655

Ser Ile Glu Met His Gly Thr Leu Glu Asp Gln Leu Ser His Leu Arg

660 665 670

Gln Tyr Glu Lys Ser Ile Val Asn Tyr Lys Pro Lys Ile Asp Gln Leu

675 680 685

Glu Gly Asp His Gln Leu Ile Gln Glu Ala Leu Ile Phe Asp Asn Lys

690 695 700

His Thr Asn Tyr Thr Met Glu His Ile Arg Val Gly Trp Glu Gln Leu

705 710 715 720

Leu Thr Thr Ile Ala Arg Thr Ile Asn Glu Val Glu Asn Gln Ile Leu

725 730 735

Thr Arg Asp Ala Lys Gly Ile Ser Gln Glu Gln Met Asn Glu Phe Arg

740 745 750

Ala Ser Phe Asn His Phe Asp Arg Asp His Ser Gly Thr Leu Gly Pro

755 760 765

Glu Glu Phe Lys Ala Cys Leu Ile Ser Leu Gly Tyr Asp Ile Gly Asn

770 775 780

Asp Pro Gln Gly Glu Ala Glu Phe Ala Arg Ile Met Ser Ile Val Asp

785 790 795 800

Pro Asn Arg Leu Gly Val Val Thr Phe Gln Ala Phe Ile Asp Phe Met

805 810 815

Ser Arg Glu Thr Ala Asp Thr Asp Thr Ala Asp Gln Val Met Ala Ser

820 825 830

Phe Lys Ile Leu Ala Gly Asp Lys Asn Tyr Ile Thr Met Asp Glu Leu

835 840 845

Arg Arg Glu Leu Pro Pro Asp Gln Ala Glu Tyr Cys Ile Ala Arg Met

850 855 860

Ala Pro Tyr Thr Gly Pro Asp Ser Val Pro Gly Ala Leu Asp Tyr Met

865 870 875 880

Ser Phe Ser Thr Ala Leu Tyr Gly Glu Ser Asp Leu

885 890

<210>8

<211>448

<212>PRT

<213> Human (Homo sapiens)

<220>

<221> Tubulin Alpha-4 chain

<222>(1)..(448)

<223> Registration Number: P05215

<400>8

Met Arg Glu Cys Ile Ser Val His Val Gly Gln Ala Gly Val Gln Met

1 5 10 15

Gly Asn Ala Cys Trp Glu Leu Tyr Cys Leu Glu His Gly Ile Gln Pro

20 25 30

Asp Gly Gln Met Pro Ser Asp Lys Thr Ile Gly Gly Gly Asp Asp Ser

35 40 45

Phe Thr Thr Phe Phe Cys Glu Thr Gly Ala Gly Lys His Val Pro Arg

50 55 60

Ala Val Phe Val Asp Leu Glu Pro Thr Val Ile Asp Glu Ile Arg Asn

65 70 75 80

Gly Pro Tyr Arg Gln Leu Phe His Pro Glu Gln Leu Ile Thr Gly Lys

85 90 95

Glu Asp Ala Ala Asn Asn Tyr Ala Arg Gly His Tyr Thr Ile Gly Lys

100 105 110

Glu Ile Ile Asp Pro Val Leu Asp Arg Ile Arg Lys Leu Ser Asp Gln

115 120 125

Cys Thr Gly Leu Gln Gly Phe Leu Val Phe His Ser Phe Gly Gly Gly

130 135 140

Thr Gly Ser Gly Phe Thr Ser Leu Leu Met Glu Arg Leu Ser Val Asp

145 150 155 160

Tyr Gly Lys Lys Ser Lys Leu Glu Phe Ser Ile Tyr Pro Ala Pro Gln

165 170 175

Val Ser Thr Ala Val Val Glu Pro Tyr Asn Ser Ile Leu Thr Thr His

180 185 190

Thr Thr Leu Glu His Ser Asp Cys Ala Phe Met Val Asp Asn Glu Ala

195 200 205

Ile Tyr Asp Ile Cys Arg Arg Asn Leu Asp Ile Glu Arg Pro Thr Tyr

210 215 220

Thr Asn Leu Asn Arg Leu Ile Ser Gln Ile Val Ser Ser Ile Thr Ala

225 230 235 240

Ser Leu Arg Phe Asp Gly Ala Leu Asn Val Asp Leu Thr Glu Phe Gln

245 250 255

Thr Asn Leu Val Pro Tyr Pro Arg Ile His Phe Pro Leu Ala Thr Tyr

260 265 270

Ala Pro Val Ile Ser Ala Glu Lys Ala Tyr His Glu Gln Leu Ser Val

275 280 285

Ala Glu Ile Thr Asn Ala Cys Phe Glu Pro Ala Asn Gln Met Val Lys

290 295 300

Cys Asp Pro Arg His Gly Lys Tyr Met Ala Cys Cys Leu Leu Tyr Arg

305 310 315 320

Gly Asp Val Val Pro Lys Asp Val Asn Ala Ala Ile Ala Ala Ile Lys

325 330 335

Thr Lys Arg Ser Ile Gln Phe Val Asp Trp Cys Pro Thr Gly Phe Lys

340 345 350

Val Gly Ile Asn Tyr Gln Pro Pro Thr Val Val Pro Gly Gly Asp Leu

355 360 365

Ala Lys Val Gln Arg Ala Val Cys Met Leu Ser Asn Thr Thr Ala Ile

370 375 380

Ala Glu Ala Trp Ala Arg Leu Asp His Lys Phe Asp Leu Met Tyr Ala

385 390 395 400

Lys Arg Ala Phe Val His Trp Tyr Val Gly Glu Gly Met Glu Glu Gly

405 410 415

Glu Phe Ser Glu Ala Arg Glu Asp Met Ala Ala Leu Glu Lys Asp Tyr

420 425 430

Glu Glu Val Gly Ile Asp Ser Tyr Glu Asp Glu Asp Glu Gly Glu Glu

435 440 445

<210>9

<211>2647

<212>PRT

<213> Human (Homo sapiens)

<220>

<221> filamin A

<222>(1)..(2647)

<223> Registration Number: P21333

<400>9

Met Ser Ser Ser Ser His Ser Arg Ala Gly Gln Ser Ala Ala Gly Ala Ala

1 5 10 15

Pro Gly Gly Gly Val Asp Thr Arg Asp Ala Glu Met Pro Ala Thr Glu

20 25 30

Lys Asp Leu Ala Glu Asp Ala Pro Trp Lys Lys Ile Gln Gln Asn Thr

35 40 45

Phe Thr Arg Trp Cys Asn Glu His Leu Lys Cys Val Ser Lys Arg Ile

50 55 60

Ala Asn Leu Gln Thr Asp Leu Ser Asp Gly Leu Arg Leu Ile Ala Leu

65 70 75 80

Leu Glu Val Leu Ser Gln Lys Lys Met His Arg Lys His Asn Gln Arg

85 90 95

Pro Thr Phe Arg Gln Met Gln Leu Glu Asn Val Ser Val Ala Leu Glu

100 105 110

Phe Leu Asp Arg Glu Ser Ile Lys Leu Val Ser Ile Asp Ser Lys Ala

115 120 125

Ile Val Asp Gly Asn Leu Lys Leu Ile Leu Gly Leu Ile Trp Thr Leu

130 135 140

Ile Leu His Tyr Ser Ile Ser Met Pro Met Trp Asp Glu Glu Glu Asp

145 150 155 160

Glu Glu Ala Lys Lys Gln Thr Pro Lys Gln Arg Leu Leu Gly Trp Ile

165 170 175

Gln Asn Lys Leu Pro Gln Leu Pro Ile Thr Asn Phe Ser Arg Asp Trp

180 185 190

Gln Ser Gly Arg Ala Leu Gly Ala Leu Val Asp Ser Cys Ala Pro Gly

195 200 205

Leu Cys Pro Asp Trp Asp Ser Trp Asp Ala Ser Lys Pro Val Thr Asn

210 215 220

Ala Arg Glu Ala Met Gln Gln Ala Asp Asp Trp Leu Gly Ile Pro Gln

225 230 235 240

Val Ile Thr Pro Glu Glu Ile Val Asp Pro Asn Val Asp Glu His Ser

245 250 255

Val Met Thr Tyr Leu Ser Gln Phe Pro Lys Ala Lys Leu Lys Pro Gly

260 265 270

Ala Pro Leu Arg Pro Lys Leu Asn Pro Lys Lys Ala Arg Ala Tyr Gly

275 280 285

Pro Gly Ile Glu Pro Thr Gly Asn Met Val Lys Lys Arg Ala Glu Phe

290 295 300

Thr Val Glu Thr Arg Ser Ala Gly Gln Gly Glu Val Leu Val Tyr Val

305 310 315 320

Glu Asp Pro Ala Gly His Gln Glu Glu Ala Lys Val Thr Ala Asn Asn

325 330 335

Asp Lys Asn Arg Thr Phe Ser Val Trp Tyr Val Pro Glu Val Thr Gly

340 345 350

Thr His Lys Val Thr Val Leu Phe Ala Gly Gln His Ile Ala Lys Ser

355 360 365

Pro Phe Glu Val Tyr Val Asp Lys Ser Gln Gly Asp Ala Ser Lys Val

370 375 380

Thr Ala Gln Gly Pro Gly Leu Glu Pro Ser Gly Asn Ile Ala Asn Lys

385 390 395 400

Thr Thr Tyr Phe Glu Ile Phe Thr Ala Gly Ala Gly Thr Gly Glu Val

405 410 415

Glu Val Val Ile Gln Asp Pro Met Gly Gln Lys Gly Thr Val Glu Pro

420 425 430

Gln Leu Glu Ala Arg Gly Asp Ser Thr Tyr Arg Cys Ser Tyr Gln Pro

435 440 445

Thr Met Glu Gly Val His Thr Val His Val Thr Phe Ala Gly Val Pro

450 455 460

Ile Pro Arg Ser Pro Tyr Thr Val Thr Val Gly Gln Ala Cys Asn Pro

465 470 475 480

Ser Ala Cys Arg Ala Val Gly Arg Gly Leu Gln Pro Lys Gly Val Arg

485 490 495

Val Lys Glu Thr Ala Asp Phe Lys Val Tyr Thr Lys Gly Ala Gly Ser

500 505 510

Gly Glu Leu Lys Val Thr Val Lys Gly Pro Lys Gly Glu Glu Arg Val

515 520 525

Lys Gln Lys Asp Leu Gly Asp Gly Val Tyr Gly Phe Glu Tyr Tyr Pro

530 535 540

Met Val Pro Gly Thr Tyr Ile Val Thr Ile Thr Trp Gly Gly Gln Asn

545 550 555 560

Ile Gly Arg Ser Pro Phe Glu Val Lys Val Gly Thr Glu Cys Gly Asn

565 570 575

Gln Lys Val Arg Ala Trp Gly Pro Gly Leu Glu Gly Gly Val Val Gly

580 585 590

Lys Ser Ala Asp Phe Val Val Glu Ala Ile Gly Asp Asp Val Gly Thr

595 600 605

Leu Gly Phe Ser Val Glu Gly Pro Ser Gln Ala Lys Ile Glu Cys Asp

610 615 620

Asp Lys Gly Asp Gly Ser Cys Asp Val Arg Tyr Trp Pro Gln Glu Ala

625 630 635 640

Gly Glu Tyr Ala Val His Val Leu Cys Asn Ser Glu Asp Ile Arg Leu

645 650 655

Ser Pro Phe Met Ala Asp Ile Arg Asp Ala Pro Gln Asp Phe His Pro

660 665 670

Asp Arg Val Lys Ala Arg Gly Pro Gly Leu Glu Lys Thr Gly Val Ala

675 680 685

Val Asn Lys Pro Ala Glu Phe Thr Val Asp Ala Lys His Gly Gly Lys

690 695 700

Ala Pro Leu Arg Val Gln Val Gln Asp Asn Glu Gly Cys Pro Val Glu

705 710 715 720

Ala Leu Val Lys Asp Asn Gly Asn Gly Thr Tyr Ser Cys Ser Tyr Val

725 730 735

Pro Arg Lys Pro Val Lys His Thr Ala Met Val Ser Trp Gly Gly Val

740 745 750

Ser Ile Pro Asn Ser Pro Phe Arg Val Asn Val Gly Ala Gly Ser His

755 760 765

Pro Asn Lys Val Lys Val Tyr Gly Pro Gly Val Ala Lys Thr Gly Leu

770 775 780

Lys Ala His Glu Pro Thr Tyr Phe Thr Val Asp Cys Ala Glu Ala Gly

785 790 795 800

Gln Gly Asp Val Ser Ile Gly Ile Lys Cys Ala Pro Gly Val Val Gly

805 810 815

Pro Ala Glu Ala Asp Ile Asp Phe Asp Ile Ile Arg Asn Asp Asn Asp

820 825 830

Thr Phe Thr Val Lys Tyr Thr Pro Arg Gly Ala Gly Ser Tyr Thr Ile

835 840 845

Met Val Leu Phe Ala Asp Gln Ala Thr Pro Thr Ser Pro Ile Arg Val

850 855 860

Lys Val Glu Pro Ser His Asp Ala Ser Lys Val Lys Ala Glu Gly Pro

865 870 875 880

Gly Leu Ser Arg Thr Gly Val Glu Leu Gly Lys Pro Thr His Phe Thr

885 890 895

Val Asn Ala Lys Ala Ala Gly Lys Gly Lys Leu Asp Val Gln Phe Ser

900 905 910

Gly Leu Thr Lys Gly Asp Ala Val Arg Asp Val Asp Ile Ile Asp His

915 920 925

His Asp Asn Thr Tyr Thr Val Lys Tyr Thr Pro Val Gln Gln Gly Pro

930 935 940

Val Gly Val Asn Val Thr Tyr Gly Gly Asp Pro Ile Pro Lys Ser Pro

945 950 955 960

Phe Ser Val Ala Val Ser Pro Ser Leu Asp Leu Ser Lys Ile Lys Val

965 970 975

Ser Gly Leu Gly Glu Lys Val Asp Val Gly Lys Asp Gln Glu Phe Thr

980 985 990

Val Lys Ser Lys Gly Ala Gly Gly Gln Gly Lys Val Ala Ser Lys Ile

995 1000 1005

Val Gly Pro Ser Gly Ala Ala Val Pro Cys Lys Val Glu Pro Gly

1010 1015 1020

Leu Gly Ala Asp Asn Ser Val Val Arg Phe Leu Pro Arg Glu Glu

1025 1030 1035

Gly Pro Tyr Glu Val Glu Val Thr Tyr Asp Gly Val Pro Val Pro

1040 1045 1050

Gly Ser Pro Phe Pro Leu Glu Ala Val Ala Pro Thr Lys Pro Ser

1055 1060 1065

Lys Val Lys Ala Phe Gly Pro Gly Leu Gln Gly Gly Ser Ala Gly

1070 1075 1080

Ser Pro Ala Arg Phe Thr Ile Asp Thr Lys Gly Ala Gly Thr Gly

1085 1090 1095

Gly Leu Gly Leu Thr Val Glu Gly Pro Cys Glu Ala Gln Leu Glu

1100 1105 1110

Cys Leu Asp Asn Gly Asp Gly Thr Cys Ser Val Ser Tyr Val Pro

1115 1120 1125

Thr Glu Pro Gly Asp Tyr Asn Ile Asn Ile Leu Phe Ala Asp Thr

1130 1135 1140

His Ile Pro Gly Ser Pro Phe Lys Ala His Val Val Pro Cys Phe

1145 1150 1155

Asp Ala Ser Lys Val Lys Cys Ser Gly Pro Gly Leu Glu Arg Ala

1160 1165 1170

Thr Ala Gly Glu Val Gly Gln Phe Gln Val Asp Cys Ser Ser Ala

1175 1180 1185

Gly Ser Ala Glu Leu Thr Ile Glu Ile Cys Ser Ala Glu Ala Gly Leu

1190 1195 1200

Pro Ala Glu Val Tyr Ile Gln Asp His Gly Asp Gly Thr His Thr

1205 1210 1215

Ile Thr Tyr Ile Pro Leu Cys Pro Gly Ala Tyr Thr Val Thr Ile

1220 1225 1230

Lys Tyr Gly Gly Gln Pro Val Pro Asn Phe Pro Ser Lys Leu Gln

1235 1240 1245

Val Glu Pro Ala Val Asp Thr Ser Gly Val Gln Cys Tyr Gly Pro

1250 1255 1260

Gly Ile Glu Gly Gln Gly Val Phe Arg Glu Ala Thr Thr Glu Phe

1265 1270 1275

Ser Val Asp Ala Arg Ala Leu Thr Gln Thr Gly Gly Pro His Val

1280 1285 1290

Lys Ala Arg Val Ala Asn Pro Ser Gly Asn Leu Thr Glu Thr Tyr

1295 1300 1305

Val Gln Asp Arg Gly Asp Gly Met Tyr Lys Val Glu Tyr Thr Pro

1310 1315 1320

Tyr Glu Glu Gly Leu His Ser Val Asp Val Thr Tyr Asp Gly Ser

1325 1330 1335

Pro Val Pro Ser Ser Pro Phe Gln Val Pro Val Thr Glu Gly Cys

1340 1345 1350

Asp Pro Ser Arg Val Arg Val His Gly Pro Gly Ile Gln Ser Gly

1355 1360 1365

Thr Thr Asn Lys Pro Asn Lys Phe Thr Val Glu Thr Arg Gly Ala

1370 1375 1380

Gly Thr Gly Gly Leu Gly Leu Ala Val Glu Gly Pro Ser Glu Ala

1385 1390 1395

Lys Met Ser Cys Met Asp Asn Lys Asp Gly Ser Cys Ser Val Glu

1400 1405 1410

Tyr Ile Pro Tyr Glu Ala Gly Thr Tyr Ser Leu Asn Val Thr Tyr

1415 1420 1425

Gly Gly His Gln Val Pro Gly Ser Pro Phe Lys Val Pro Val His

1430 1435 1440

Asp Val Thr Asp Ala Ser Lys Val Lys Cys Ser Gly Pro Gly Leu

1445 1450 1455

Ser Pro Gly Met Val Arg Ala Asn Leu Pro Gln Ser Phe Gln Val

1460 1465 1470

Asp Thr Ser Lys Ala Gly Val Ala Pro Leu Gln Val Lys Val Gln

1475 1480 1485

Gly Pro Lys Gly Leu Val Glu Pro Val Asp Val Val Asp Asn Ala

1490 1495 1500

Asp Gly Thr Gln Thr Val Asn Tyr Val Pro Ser Arg Glu Gly Pro

1505 1510 1515

Tyr Ser Ile Ser Val Leu Tyr Gly Asp Glu Glu Val Pro Arg Ser

1520 1525 1530

Pro Phe Lys Val Lys Val Leu Pro Thr His Asp Ala Ser Lys Val

1535 1540 1545

Lys Ala Ser Gly Pro Gly Leu Asn Thr Thr Gly Val Pro Ala Ser

1550 1555 1560

Leu Pro Val Glu Phe Thr Ile Asp Ala Lys Asp Ala Gly Glu Gly

1565 1570 1575

Leu Leu Ala Val Gln Ile Thr Asp Pro Glu Gly Lys Pro Lys Lys

1580 1585 1590

Thr His Ile Gln Asp Asn His Asp Gly Thr Tyr Thr Val Ala Tyr

1595 1600 1605

Val Pro Asp Val Thr Gly Arg Tyr Thr Ile Leu Ile Lys Tyr Gly

1610 1615 1620

Gly Asp Glu Ile Pro Phe Ser Pro Tyr Arg Val Arg Ala Val Pro

1625 1630 1635

Thr Gly Asp Ala Ser Lys Cys Thr Val Thr Val Ser Ile Gly Gly

1640 1645 1650

His Gly Leu Gly Ala Gly Ile Gly Pro Thr Ile Gln Ile Gly Glu

1655 1660 1665

Glu Thr Val Ile Thr Val Asp Thr Lys Ala Ala Gly Lys Gly Lys

1670 1675 1680

Val Thr Cys Thr Val Cys Thr Pro Asp Gly Ser Glu Val Asp Val

1685 1690 1695

Asp Val Val Glu Asn Glu Asp Gly Thr Phe Asp Ile Phe Tyr Thr

1700 1705 1710

Ala Pro Gln Pro Gly Lys Tyr Val Ile Cys Val Arg Phe Gly Gly

1715 1720 1725

Glu His Val Pro Asn Ser Pro Phe Gln Val Thr Ala Leu Ala Gly

1730 1735 1740

Asp Gln Pro Ser Val Gln Pro Pro Leu Arg Ser Gln Gln Leu Ala

1745 1750 1755

Pro Gln Tyr Thr Tyr Ala Gln Gly Gly Gln Gln Thr Trp Ala Pro

1760 1765 1770

Glu Arg Pro Leu Val Gly Val Asn Gly Leu Asp Val Thr Ser Leu

1775 1780 1785

Arg Pro Phe Asp Leu Val Ile Pro Phe Thr Ile Lys Lys Gly Glu

1790 1795 1800

Ile Thr Gly Glu Val Arg Met Pro Ser Gly Lys Val Ala Gln Pro

1805 1810 1815

Thr Ile Thr Asp Asn Lys Asp Gly Thr Val Thr Val Arg Tyr Ala

1820 1825 1830

Pro Ser Glu Ala Gly Leu His Glu Met Asp Ile Arg Tyr Asp Asn

1835 1840 1845

Met His Ile Pro Gly Ser Pro Leu Gln Phe Tyr Val Asp Tyr Val

1850 1855 1860

Asn Cys Gly His Val Thr Ala Tyr Gly Pro Gly Leu Thr His Gly

1865 1870 1875

Val Val Asn Lys Pro Ala Thr Phe Thr Val Asn Thr Lys Asp Ala

1880 1885 1890

Gly Glu Gly Gly Leu Ser Leu Ala Ile Glu Gly Pro Ser Lys Ala

1895 1900 1905

Glu Ile Ser Cys Thr Asp Asn Gln Asp Gly Thr Cys Ser Val Ser

1910 1915 1920

Tyr Leu Pro Val Leu Pro Gly Asp Tyr Ser Ile Leu Val Lys Tyr

1925 1930 1935

Asn Glu Gln His Val Pro Gly Ser Pro Phe Thr Ala Arg Val Thr

1940 1945 1950

Gly Asp Asp Ser Met Arg Met Ser His Leu Lys Val Gly Ser Ala

1955 1960 1965

Ala Asp Ile Pro Ile Asn Ile Ser Glu Thr Asp Leu Ser Leu Leu

1970 1975 1980

Thr Ala Thr Val Val Pro Pro Ser Gly Arg Glu Glu Pro Cys Leu

1985 1990 1995

Leu Lys Arg Leu Arg Asn Gly His Val Gly Ile Ser Phe Val Pro

2000 2005 2010

Lys Glu Thr Gly Glu His Leu Val His Val Lys Lys Asn Gly Gln

2015 2020 2025

His Val Ala Ser Ser Pro Ile Pro Val Val Ile Ser Gln Ser Glu

2030 2035 2040

Ile Gly Asp Ala Ser Arg Val Arg Val Ser Gly Gln Gly Leu His

2045 2050 2055

Glu Gly His Thr Phe Glu Pro Ala Glu Phe Ile Ile Asp Thr Arg

2060 2065 2070

Asp Ala Gly Tyr Gly Gly Leu Ser Leu Ser Ile Glu Gly Pro Ser

2075 2080 2085

Lys Val Asp Ile Asn Thr Glu Asp Leu Glu Asp Gly Thr Cys Arg

2090 2095 2100

Val Thr Tyr Cys Pro Thr Glu Pro Gly Asn Tyr Ile Ile Asn Ile

2105 2110 2115

Lys Phe Ala Asp Gln His Val Pro Gly Ser Pro Phe Ser Val Lys

2120 2125 2130

Val Thr Gly Glu Gly Arg Val Lys Glu Ser Ile Thr Arg Arg Arg

2135 2140 2145

Arg Ala Pro Ser Val Ala Asn Val Gly Ser His Cys Asp Leu Ser

2150 2155 2160

Leu Lys Ile Pro Glu Ile Ser Ile Gln Asp Met Thr Ala Gln Val

2165 2170 2175

Thr Ser Pro Ser Gly Lys Thr His Glu Ala Glu Ile Val Glu Gly

2180 2185 2190

Glu Asn His Thr Tyr Cys Ile Arg Phe Val Pro Ala Glu Met Gly

2195 2200 2205

Thr His Thr Val Ser Val Lys Tyr Lys Gly Gln His Val Pro Gly

2210 2215 2220

Ser Pro Phe Gln Phe Thr Val Gly Pro Leu Gly Glu Gly Gly Ala

2225 2230 2235

His Lys Val Arg Ala Gly Gly Pro Gly Leu Glu Arg Ala Glu Ala

2240 2245 2250

Gly Val Pro Ala Glu Phe Ser Ile Trp Thr Arg Glu Ala Gly Ala

2255 2260 2265

Gly Gly Leu Ala Ile Ala Val Glu Gly Pro Ser Lys Ala Glu Ile

2270 2275 2280

Ser Phe Glu Asp Arg Lys Asp Gly Ser Cys Gly Val Ala Tyr Val

2285 2290 2295

Val Gln Glu Pro Gly Asp Tyr Glu Val Ser Val Lys Phe Asn Glu

2300 2305 2310

Glu His Ile Pro Asp Ser Pro Phe Val Val Pro Val Ala Ser Pro

2315 2320 2325

Ser Gly Asp Ala Arg Arg Leu Thr Val Ser Ser Leu Gln Glu Ser

2330 2335 2340

Gly Leu Lys Val Asn Gln Pro Ala Ser Phe Ala Val Ser Leu Asn

2345 2350 2355

Gly Ala Lys Gly Ala Ile Asp Ala Lys Val His Ser Pro Ser Gly

2360 2365 2370

Ala Leu Glu Glu Cys Tyr Val Thr Glu Ile Asp Gln Asp Lys Tyr

2375 2380 2385

Ala Val Arg Phe Ile Pro Arg Glu Asn Gly Val Tyr Leu Ile Asp

2390 2395 2400

Val Lys Phe Asn Gly Thr His Ile Pro Gly Ser Pro Phe Lys Ile

2405 2410 2415

Arg Val Gly Glu Pro Gly His Gly Gly Asp Pro Gly Leu Val Ser

2420 2425 2430

Ala Tyr Gly Ala Gly Leu Glu Gly Gly Val Thr Gly Asn Pro Ala

2435 2440 2445

Glu Phe Val Val Asn Thr Ser Asn Ala Gly Ala Gly Ala Leu Ser

2450 2455 2460

Val Thr Ile Asp Gly Pro Ser Lys Val Lys Met Asp Cys Gln Glu

2465 2470 2475

Cys Pro Glu Gly Tyr Arg Val Thr Tyr Thr Pro Met Ala Pro Gly

2480 2485 2490

Ser Tyr Leu Ile Ser Ile Lys Tyr Gly Gly Pro Tyr His Ile Gly

2495 2500 2505

Gly Ser Pro Phe Lys Ala Lys Val Thr Gly Pro Arg Leu Val Ser

2510 2515 2520

Asn His Ser Leu His Glu Thr Ser Ser Val Phe Val Asp Ser Leu

2525 2530 2535

Thr Lys Ala Thr Cys Ala Pro Gln His Gly Ala Pro Gly Pro Gly

2540 2545 2550

Pro Ala Asp Ala Ser Lys Val Val Ala Lys Gly Leu Gly Leu Ser

2555 2560 2565

Lys Ala Tyr Val Gly Gln Lys Ser Ser Phe Thr Val Asp Cys Ser

2570 2575 2580

Lys Ala Gly Asn Asn Met Leu Leu Val Gly Val His Gly Pro Arg

2585 2590 2595

Thr Pro Cys Glu Glu Ile Leu Val Lys His Val Gly Ser Arg Leu

2600 2605 2610

Tyr Ser Val Ser Tyr Leu Leu Lys Asp Lys Gly Glu Tyr Thr Leu

2615 2620 2625

Val Val Lys Trp Gly His Glu His Ile Pro Gly Ser Pro Tyr Arg

2630 2635 2640

Val Val Val Pro

2645

<210>10

<211>199

<212>PRT

<213> Human (Homo sapiens)

<220>

<221>Transgelin 2

<222>(1)..(199)

<223> December 6, 2002 Registration number: P37802

<400>10

Met Ala Asn Arg Gly Pro Ala Tyr Gly Leu Ser Arg Glu Val Gln Gln

1 5 10 15

Lys Ile Glu Lys Gln Tyr Asp Ala Asp Leu Glu Gln Ile Leu Ile Gln

20 25 30

Trp Ile Thr Thr Gln Cys Arg Lys Asp Val Gly Arg Pro Gln Pro Gly

35 40 45

Arg Glu Asn Phe Gln Asn Trp Leu Lys Asp Gly Thr Val Leu Cys Glu

50 55 60

Leu Ile Asn Ala Leu Tyr Pro Glu Gly Gln Ala Pro Val Lys Lys Ile

65 70 75 80

Gln Ala Ser Thr Met Ala Phe Lys Gln Met Glu Gln Ile Ser Gln Phe

85 90 95

Leu Gln Ala Ala Glu Arg Tyr Gly Ile Asn Thr Thr Asp Ile Phe Gln

100 105 110

Thr Val Asp Leu Trp Glu Gly Lys Asn Met Ala Cys Val Gln Arg Thr

115 120 125

Leu Met Asn Leu Gly Gly Leu Ala Val Ala Arg Asp Asp Gly Leu Phe

130 135 140

Ser Gly Asp Pro Asn Trp Phe Pro Lys Lys Ser Lys Glu Asn Pro Arg

145 150 155 160

Asn Phe Ser Asp Asn Gln Leu Gln Glu Gly Lys Asn Val Ile Gly Leu

165 170 175

Gln Met Gly Thr Asn Arg Gly Ala Ser Gln Ala Gly Met Thr Gly Tyr

180 185 190

Gly Met Pro Arg Gln Ile Leu

195

<210>11

<211>248

<212>PRT

<213> Human (Homo sapiens)

<220>

<221> Tropomyosin Alpha-4 Chain

<222>(1)..(248)

<223> Registration Number: P07226

<400>11

Met Ala Gly Leu Asn Ser Leu Glu Ala Val Lys Arg Lys Ile Gln Ala

1 5 10 15

Leu Gln Gln Gln Ala Asp Glu Ala Glu Asp Arg Ala Gln Gly Leu Gln

20 25 30

Arg Glu Leu Asp Gly Glu Arg Glu Arg Arg Glu Lys Ala Glu Gly Asp

35 40 45

Val Ala Ala Leu Asn Arg Arg Ile Gln Leu Val Glu Glu Glu Leu Asp

50 55 60

Arg Ala Gln Glu Arg Leu Ala Thr Ala Leu Gln Lys Leu Glu Glu Ala

65 70 75 80

Glu Lys Ala Ala Asp Glu Ser Glu Arg Gly Met Lys Val Ile Glu Asn

85 90 95

Arg Ala Met Lys Asp Glu Glu Lys Met Glu Ile Gln Glu Met Gln Leu

100 105 110

Lys Glu Ala Lys His Ile Ala Glu Glu Ala Asp Arg Lys Tyr Glu Glu

115 120 125

Val Ala Arg Lys Leu Val Ile Leu Glu Gly Glu Leu Glu Arg Ala Glu

130 135 140

Glu Arg Ala Glu Val Ser Glu Leu Lys Cys Gly Asp Leu Glu Glu Glu Glu

145 150 155 160

Leu Lys Asn Val Thr Asn Asn Leu Lys Ser Leu Glu Ala Ala Ser Glu

165 170 175

Lys Tyr Ser Glu Lys Glu Asp Lys Tyr Glu Glu Glu Ile Lys Leu Leu

180 185 190

Ser Asp Lys Leu Lys Glu Ala Glu Thr Arg Ala Glu Phe Ala Glu Arg

195 200 205

Thr Val Ala Lys Leu Glu Lys Thr Ile Asp Asp Leu Glu Glu Lys Leu

210 215 220

Ala Gln Ala Lys Glu Glu Asn Val Gly Leu His Gln Thr Leu Asp Gln

225 230 235 240

Thr Leu Asn Glu Leu Asn Cys Ile

245

<210>12

<211>793

<212>PRT

<213> Human (Homo sapiens)

<220>

<221> Calmodulin

<222>(1)..(793)

<223> December 6, 2002 Registration number: Q05682

<400>12

Met Asp Asp Phe Glu Arg Arg Arg Glu Leu Arg Arg Gln Lys Arg Glu

1 5 10 15

Glu Met Arg Leu Glu Ala Glu Arg Ile Ala Tyr Gln Arg Asn Asp Asp

20 25 30

Asp Glu Glu Glu Ala Ala Arg Glu Arg Arg Arg Arg Ala Arg Gln Glu

35 40 45

Arg Leu Arg Gln Lys Gln Glu Glu Glu Ser Leu Gly Gln Val Thr Asp

50 55 60

Gln Val Glu Val Asn Ala Gln Asn Ser Val Pro Asp Glu Glu Ala Lys

65 70 75 80

Thr Thr Thr Thr Asn Thr Gln Val Glu Gly Asp Asp Glu Ala Ala Phe

85 90 95

Leu Glu Arg Leu Ala Arg Arg Glu Glu Arg Arg Gln Lys Arg Leu Gln

100 105 110

Glu Ala Leu Glu Arg Gln Lys Glu Phe Asp Pro Thr Ile Thr Asp Ala

115 120 125

Ser Leu Ser Leu Pro Ser Arg Arg Met Gln Asn Asp Thr Ala Glu Asn

130 135 140

Glu Thr Thr Glu Lys Glu Glu Lys Ser Glu Ser Arg Gln Glu Arg Tyr

145 150 155 160

Glu Ile Glu Glu Thr Glu Thr Val Thr Lys Ser Tyr Gln Lys Asn Asp

165 170 175

Trp Arg Asp Ala Glu Glu Asn Lys Lys Glu Asp Lys Glu Lys Glu Glu

180 185 190

Glu Glu Glu Glu Lys Pro Lys Arg Gly Ser Ile Gly Glu Asn Gln Val

195 200 205

Glu Val Met Val Glu Glu Lys Thr Thr Glu Ser Gln Glu Glu Thr Val

210 215 220

Val Met Ser Leu Lys Asn Gly Gln Ile Ser Ser Glu Glu Pro Lys Gln

225 230 235 240

Glu Glu Glu Arg Glu Gln Gly Ser Asp Glu Ile Ser His His Glu Lys

245 250 255

Met Glu Glu Glu Asp Lys Glu Arg Ala Glu Ala Glu Arg Ala Arg Leu

260 265 270

Glu Ala Glu Glu Arg Glu Arg Ile Lys Ala Glu Gln Asp Lys Lys Ile

275 280 285

Ala Asp Glu Arg Ala Arg Ile Glu Ala Glu Glu Lys Ala Ala Ala Gln

290 295 300

Glu Arg Glu Arg Arg Glu Ala Glu Glu Arg Glu Arg Met Arg Glu Glu

305 310 315 320

Glu Lys Arg Ala Ala Glu Glu Arg Gln Arg Ile Lys Glu Glu Glu Lys

325 330 335

Arg Ala Ala Glu Glu Arg Gln Arg Ile Lys Glu Glu Glu Lys Arg Ala

340 345 350

Ala Glu Glu Arg Gln Arg Ile Lys Glu Glu Glu Lys Arg Ala Ala Glu

355 360 365

Glu Arg Gln Arg Ala Arg Ala Glu Glu Glu Glu Lys Ala Lys Val Glu

370 375 380

Glu Gln Lys Arg Asn Lys Gln Leu Glu Glu Lys Lys Arg Ala Met Gln

385 390 395 400

Glu Thr Lys Ile Lys Gly Glu Lys Val Glu Gln Lys Ile Glu Gly Lys

405 410 415

Trp Val Asn Glu Lys Lys Ala Gln Glu Asp Lys Leu Gln Thr Ala Val

420 425 430

Leu Lys Lys Gln Gly Glu Glu Lys Gly Thr Lys Val Gln Ala Lys Arg

435 440 445

Glu Lys Leu Gln Glu Asp Lys Pro Thr Phe Lys Lys Glu Glu Ile Lys

450 455 460

Asp Glu Lys Ile Lys Lys Asp Lys Glu Pro Lys Glu Glu Val Lys Ser

465 470 475 480

Phe Met Asp Arg Lys Lys Gly Phe Thr Glu Val Lys Ser Gln Asn Gly

485 490 495

Glu Phe Met Thr His Lys Leu Lys His Thr Glu Asn Thr Phe Ser Arg

500 505 510

Pro Gly Gly Arg Ala Ser Val Asp Thr Lys Glu Ala Glu Gly Ala Pro

515 520 525

Gln Val Glu Ala Gly Lys Arg Leu Glu Glu Leu Arg Arg Arg Arg Arg Gly

530 535 540

Glu Thr Glu Ser Glu Glu Phe Glu Lys Leu Lys Gln Lys Gln Gln Glu

545 550 555 560

Ala Ala Leu Glu Leu Glu Glu Leu Lys Lys Lys Arg Glu Glu Arg Arg

565 570 575

Lys Val Leu Glu Glu Glu Glu Gln Arg Arg Lys Gln Glu Glu Ala Asp

580 585 590

Arg Lys Leu Arg Glu Glu Glu Glu Lys Arg Arg Leu Lys Glu Glu Ile

595 600 605

Glu Arg Arg Arg Ala Glu Ala Ala Glu Lys Arg Gln Lys Met Pro Glu

610 615 620

Asp Gly Leu Ser Asp Asp Lys Lys Pro Phe Lys Cys Phe Thr Pro Lys

625 630 635 640

Gly Ser Ser Leu Lys Ile Glu Glu Arg Ala Glu Phe Leu Asn Lys Ser

645 650 655

Val Gln Lys Ser Ser Gly Val Lys Ser Thr His Gln Ala Ala Ile Val

660 665 670

Ser Lys Ile Asp Ser Arg Leu Glu Gln Tyr Thr Ser Ala Ile Glu Gly

675 680 685

Thr Lys Ser Ala Lys Pro Thr Lys Pro Ala Ala Ser Asp Leu Pro Val

690 695 700

Pro Ala Glu Gly Val Arg Asn Ile Lys Ser Met Trp Glu Lys Gly Asn

705 710 715 720

Val Phe Ser Ser Pro Thr Ala Ala Gly Thr Pro Asn Lys Glu Thr Ala

725 730 735

Gly Leu Lys Val Gly Val Ser Ser Arg Ile Asn Glu Trp Leu Thr Lys

740 745 750

Thr Pro Asp Gly Asn Lys Ser Pro Ala Pro Lys Pro Ser Asp Leu Arg

755 760 765

Pro Gly Asp Val Ser Ser Lys Arg Asn Leu Trp Glu Lys Gln Ser Val

770 775 780

Asp Lys Val Thr Ser Pro Thr Lys Val

785 790

<210>13

<211>458

<212>PRT

<213> Human (Homo sapiens)

<220>

<221> Alpha-enolase

<222>(1)..(458)

<223> December 6, 2002 Registration number: Q05524

<400>13

Met Ser Ile Leu Lys Ile Ile His Ala Arg Asp Ile Phe Glu Ser Arg

1 5 10 15

Gly Asn Pro Thr Val Glu Val Asp Leu Tyr Thr Asn Lys Gly Gly Leu

20 25 30

Phe Gly Arg Ala Ala Val Pro Ser Gly Ala Ser Thr Gly Ile Tyr Glu

35 40 45

Ala Leu Leu Glu Leu Arg Asp Asn Asp Lys Thr Arg Tyr Met Gly Gly

50 55 60

Lys Gly Val Ser Lys Ala Val Glu His Ile Ile Asn Lys Thr Ile Ala

65 70 75 80

Pro Ala Leu Ile Ser Lys Asn Val Asn Val Val Glu Gln Asp Lys Ile

85 90 95

Asp Asn Leu Met Leu Asp Met Asp Gly Ser Glu Asn Lys Ser Lys Phe

100 105 110

Gly Ala Asn Ala Ile Leu Gly Val Ser Leu Ala Val Cys Ser Asn Ala

115 120 125

Gly Ala Thr Ala Glu Lys Gly Val Pro Leu Tyr Arg His Ile Ala Asp

130 135 140

Leu Ala Gly Asn Asn Pro Glu Val Ile Leu Pro Val Pro Ala Phe Asn

145 150 155 160

Val Ile Asn Gly Gly Ser His Ala Gly Asn Lys Leu Ala Met Gln Glu

165 170 175

Phe Met Ile Pro Pro Cys Gly Ala Asp Arg Phe Asn Asp Ala Ile Arg

180 185 190

Ile Gly Ala Glu Val Tyr His Asn Leu Lys Asn Val Ile Lys Glu Lys

195 200 205

Tyr Gly Lys Asp Ala Thr Asn Val Gly Asp Glu Gly Gly Phe Ala Pro

210 215 220

Asn Ile Leu Glu Asn Lys Glu Ala Leu Glu Leu Leu Lys Thr Ala Ile

225 230 235 240

Gly Lys Ala Gly Tyr Ser Asp Lys Val Val Ile Gly Met Asp Val Ala

245 250 255

Ala Ser Glu Phe Tyr Arg Asp Gly Lys Tyr Asp Leu Asp Phe Asn Ser

260 265 270

Pro Asp Asp Pro Ser Arg Tyr Ile Ser Pro Asp Gln Leu Ala Asp Leu

275 280 285

Tyr Lys Gly Phe Val Leu Gly His Ala Val Lys Asn Tyr Pro Val Gly

290 295 300

Val Ser Ile Glu Asp Pro Pro Phe Asp Gln Asp Asp Trp Gly Ala Trp

305 310 315 320

Lys Lys Leu Phe Thr Gly Ser Leu Val Gly Ile Gln Val Val Gly Asp

325 330 335

Asp Leu Thr Val Thr Lys Pro Glu Ala Arg Ile Ala Lys Ala Val Glu

340 345 350

Glu Val Lys Ala Cys Asn Cys Leu Leu Leu Leu Lys Val Asn Gln Ile

355 360 365

Gly Ser Val Thr Glu Ser Leu Gln Ala Cys Lys Leu Ala Gln Ser Asn

370 375 380

Gly Trp Gly Val Met Pro Val Ser His Arg Leu Ser Gly Glu Thr Glu

385 390 395 400

Asp Thr Phe Met Ala Asp Leu Val Val Gly Leu Cys Thr Gly Gln Ile

405 410 415

Lys Thr Gly Pro Thr Cys Arg Ser Glu Arg Leu Ala Lys Tyr Asn Gln

420 425 430

Leu Leu Arg Ile Glu Glu Ala Glu Ala Gly Ser Lys Ala Arg Phe Ala

435 440 445

Gly Arg Asn Phe Arg Asn Pro Arg Ile Asn

450 455

<210>14

<211>408

<212>PRT

<213> Human (Homo sapiens)

<220>

<221> aminoacylase-1

<222>(1)..(408)

<223> December 6, 2002 Registration number: Q03154

<400>14

Met Thr Ser Lys Gly Pro Glu Glu Glu His Pro Ser Val Thr Leu Phe

1 5 10 15

Arg Gln Tyr Leu Arg Ile Arg Thr Val Gln Pro Lys Pro Asp Tyr Gly

20 25 30

Ala Ala Val Ala Phe Phe Glu Glu Thr Ala Arg Gln Leu Gly Leu Gly

35 40 45

Cys Gln Lys Val Glu Val Ala Pro Gly Tyr Val Val Thr Val Leu Thr

50 55 60

Trp Pro Gly Thr Asn Pro Thr Leu Ser Ser Ile Leu Leu Asn Ser His

65 70 75 80

Thr Asp Val Val Pro Val Phe Lys Glu His Trp Ser His Asp Pro Phe

85 90 95

Glu Ala Phe Lys Asp Ser Glu Gly Tyr Ile Tyr Ala Arg Gly Ala Gln

100 105 110

Asp Met Lys Cys Val Ser Ile Gln Tyr Leu Glu Ala Val Arg Arg Leu

115 120 125

Lys Val Glu Gly His Arg Phe Pro Arg Thr Ile His Met Thr Phe Val

130 135 140

Pro Asp Glu Glu Val Gly Gly His Gln Gly Met Glu Leu Phe Val Gln

145 150 155 160

Arg Pro Glu Phe His Ala Leu Arg Ala Gly Phe Ala Leu Asp Glu Gly

165 170 175

Ile Ala Asn Pro Thr Asp Ala Phe Thr Val Phe Tyr Ser Glu Arg Ser

180 185 190

Pro Trp Trp Val Arg Val Thr Ser Thr Gly Arg Pro Gly His Ala Ser

195 200 205

Arg Phe Met Glu Asp Thr Ala Ala Glu Lys Leu His Lys Val Val Asn

210 215 220

Ser Ile Leu Ala Phe Arg Glu Lys Glu Trp Gln Arg Leu Gln Ser Asn

225 230 235 240

Pro His Leu Lys Glu Gly Ser Val Thr Ser Val Asn Leu Thr Lys Leu

245 250 255

Glu Gly Gly Val Ala Tyr Asn Val Ile Pro Ala Thr Met Ser Ala Ser

260 265 270

Phe Asp Phe Arg Val Ala Pro Asp Val Asp Phe Lys Ala Phe Glu Glu

275 280 285

Gln Leu Gln Ser Trp Cys Gln Ala Ala Gly Glu Gly Val Thr Leu Glu

290 295 300

Phe Ala Gln Lys Trp Met His Pro Gln Val Thr Pro Thr Asp Asp Ser

305 310 315 320

Asn Pro Trp Trp Ala Ala Phe Ser Arg Val Cys Lys Asp Met Asn Leu

325 330 335

Thr Leu Glu Pro Glu Ile Met Pro Ala Ala Thr Asp Asn Arg Tyr Ile

340 345 350

Arg Ala Val Gly Val Pro Ala Leu Gly Phe Ser Pro Met Asn Arg Thr

355 360 365

Pro Val Leu Leu His Asp His Asp Glu Arg Leu His Glu Ala Val Phe

370 375 380

Leu Arg Gly Val Asp Ile Tyr Thr Arg Leu Leu Pro Ala Leu Ala Ser

385 390 395 400

Val Pro Ala Leu Pro Ser Asp Ser

405

<210>15

<211>277

<212>PRT

<213> Human (Homo sapiens)

<220>

<221> F-actin capping protein beta-subunit

<222>(1)..(277)

<223> December 6, 2002 Registration number: P47756

<400>15

Met Ser Asp Gln Gln Leu Asp Cys Ala Leu Asp Leu Met Arg Arg Leu

1 5 10 15

Pro Pro Gln Gln Ile Glu Lys Asn Leu Ser Asp Leu Ile Asp Leu Val

20 25 30

Pro Ser Leu Cys Glu Asp Leu Leu Ser Ser Val Asp Gln Pro Leu Lys

35 40 45

Ile Ala Arg Asp Lys Val Val Gly Lys Asp Tyr Leu Leu Cys Asp Tyr

50 55 60

Asn Arg Asp Gly Asp Ser Tyr Arg Ser Pro Trp Ser Asn Lys Tyr Asp

65 70 75 80

Pro Pro Leu Glu Asp Gly Ala Met Pro Ser Ala Arg Leu Arg Lys Leu

85 90 95

Glu Val Glu Ala Asn Asn Ala Phe Asp Gln Tyr Arg Asp Leu Tyr Phe

100 105 110

Glu Gly Gly Val Ser Ser Val Tyr Leu Trp Asp Leu Asp His Gly Phe

115 120 125

Ala Gly Val Ile Leu Ile Lys Lys Ala Gly Asp Gly Ser Lys Lys Ile

130 135 140

Lys Gly Cys Trp Asp Ser Ile His Val Val Glu Val Gln Glu Lys Ser

145 150 155 160

Ser Gly Arg Thr Ala His Tyr Lys Leu Thr Ser Thr Val Met Leu Trp

165 170 175

Leu Gln Thr Asn Lys Ser Gly Ser Gly Thr Met Asn Leu Gly Gly Ser

180 185 190

Leu Thr Arg Gln Met Glu Lys Asp Glu Thr Val Ser Asp Cys Ser Pro

195 200 205

His Ile Ala Asn Ile Gly Arg Leu Val Glu Asp Met Glu Asn Lys Ile

210 215 220

Arg Ser Thr Leu Asn Glu Ile Tyr Phe Gly Lys Thr Lys Asp Ile Val

225 230 235 240

Asn Gly Leu Arg Ser Ile Asp Ala Ile Pro Asp Asn Gln Lys Phe Lys

245 250 255

Gln Leu Gln Arg Glu Leu Ser Gln Val Leu Thr Gln Arg Gln Ile Tyr

260 265 270

Ile Gln Pro Asp Asn

275

<210>16

<211>289

<212>PRT

<213> Human (Homo sapiens)

<220>

<221> Inorganic pyrophosphatase

<222>(1)..(289)

<223> December 6, 2002 Registration number: Q15181

<400>16

Met Ser Gly Phe Ser Thr Glu Glu Arg Ala Ala Pro Phe Ser Leu Glu

1 5 10 15

Tyr Arg Val Phe Leu Lys Asn Glu Lys Gly Gln Tyr Ile Ser Pro Phe

20 25 30

His Asp Ile Pro Ile Tyr Ala Asp Lys Asp Val Phe His Met Val Val

35 40 45

Glu Val Pro Arg Trp Ser Asn Ala Lys Met Glu Ile Ala Thr Lys Asp

50 55 60

Pro Leu Asn Pro Ile Lys Gln Asp Val Lys Lys Gly Lys Leu Arg Tyr

65 70 75 80

Val Ala Asn Leu Phe Pro Tyr Lys Gly Tyr Ile Trp Asn Tyr Gly Ala

85 90 95

Tle Pro Gln Thr Trp Glu Asp Pro Gly His Asn Asp Lys His Thr Gly

100 105 110

Cys Cys Gly Asp Asn Asp Pro Ile Asp Val Cys Glu Ile Gly Ser Lys

115 120 125

Val Cys Ala Arg Gly Glu Ile Ile Gly Val Lys Val Leu Gly Ile Leu

130 135 140

Ala Met Ile Asp Glu Gly Glu Thr Asp Trp Lys Val Ile Ala Ile Asn

145 150 155 160

Val Asp Asp Pro Asp Ala Ala Asn Tyr Asn Asp Ile Asn Asp Val Lys

165 170 175

Arg Leu Lys Pro Gly Tyr Leu Glu Ala Thr Val Asp Trp Phe Arg Arg

180 185 190

Tyr Lys Val Pro Asp Gly Lys Pro Glu Asn Glu Phe Ala Phe Asn Ala

195 200 205

Glu Phe Lys Asp Lys Asp Phe Ala Ile Asp Ile Ile Lys Ser Thr His

210 215 220

Asp His Trp Lys Ala Leu Val Thr Lys Lys Thr Asn Gly Lys Gly Ile

225 230 235 240

Ser Cys Met Asn Thr Thr Leu Ser Glu Ser Pro Phe Lys Cys Asp Pro

245 250 255

Asp Ala Ala Arg Ala Ile Val Asp Ala Leu Pro Pro Pro Cys Glu Ser

260 265 270

Ala Cys Thr Val Pro Thr Asp Val Asp Lys Trp Phe His His Gln Lys

275 280 285

Asn

<210>17

<211>250

<212>PRT

<213> Human (Homo sapiens)

<220>

<221> galectin 3 (galactose-specific lectin 3)

<222>(1)..(250)

<223> December 6, 2002 Registration number: P17931

<400>17

Met Ala Asp Asn Phe Ser Leu His Asp Ala Leu Ser Gly Ser Gly Asn

1 5 10 15

Pro Asn Pro Gln Gly Trp Pro Gly Ala Trp Gly Asn Gln Pro Ala Gly

20 25 30

Ala Gly Gly Tyr Pro Gly Ala Ser Tyr Pro Gly Ala Tyr Pro Gly Gln

35 40 45

Ala Pro Pro Gly Ala Tyr Pro Gly Gln Ala Pro Pro Gly Ala Tyr His

50 55 60

Gly Ala Pro Gly Ala Tyr Pro Gly Ala Pro Ala Pro Gly Val Tyr Pro

65 70 75 80

Gly Pro Pro Ser Gly Pro Gly Ala Tyr Pro Ser Ser Gly Gln Pro Ser

85 90 95

Ala Pro Gly Ala Tyr Pro Ala Thr Gly Pro Tyr Gly Ala Pro Ala Gly

100 105 110

Pro Leu Ile Val Pro Tyr Asn Leu Pro Leu Pro Gly Gly Val Val Pro

115 120 125

Arg Met Leu Ile Thr Ile Leu Gly Thr Val Lys Pro Asn Ala Asn Arg

130 135 140

Ile Ala Leu Asp Phe Gln Arg Gly Asn Asp Val Ala Phe His Phe Asn

145 150 155 160

Pro Arg Phe Asn Glu Asn Asn Arg Arg Val Ile Val Cys Asn Thr Lys

165 170 175

Leu Asp Asn Asn Trp Gly Arg Glu Glu Arg Gln Ser Val Phe Pro Phe

180 185 190

Glu Ser Gly Lys Pro Phe Lys Ile Gln Val Leu Val Glu Pro Asp His

195 200 205

Phe Lys Val Ala Val Asn Asp Ala His Leu Leu Gln Tyr Asn His Arg

210 215 220

Val Lys Lys Leu Asn Glu Ile Ser Lys Leu Gly Ile Ser Gly Asp Ile

225 230 235 240

Asp Leu Thr Ser Ala Ser Tyr Thr Met Ile

245 250

<210>18

<211>347

<212>PRT

<213> Human (Homo sapiens)

<220>

<221> Voltage-dependent anion-selective channel protein 2 (VDAC-2)

<222>(1)..(347)

<223> December 6, 2002 Registration number: P45880

<400>18

Met Ser Trp Cys Asn Glu Leu Arg Leu Pro Ala Leu Lys Gln His Ser

1 5 10 15

Ile Gly Arg Gly Leu Glu Ser His Ile Thr Met Cys Ile Pro Pro Ser

20 25 30

Tyr Ala Asp Leu Gly Lys Ala Ala Arg Asp Ile Phe Asn Lys Gly Phe

35 40 45

Gly Phe Gly Leu Val Lys Leu Asp Val Lys Thr Lys Ser Cys Ser Gly

50 55 60

Val Glu Phe Ser Thr Ser Gly Ser Ser Asn Thr Asp Thr Gly Lys Val

65 70 75 80

Thr Gly Thr Leu Glu Thr Lys Tyr Lys Trp Cys Glu Tyr Gly Leu Thr

85 90 95

Phe Thr Glu Lys Trp Asn Thr Asp Asn Thr Leu Gly Thr Glu Ile Ala

100 105 110

Ile Glu Asp Gln Ile Cys Gln Gly Leu Lys Leu Thr Phe Asp Thr Thr

115 120 125

Phe Ser Pro Asn Thr Gly Lys Lys Ser Gly Lys Ile Lys Ser Ser Tyr

130 135 140

Lys Arg Glu Cys Ile Asn Leu Gly Cys Asp Val Asp Phe Asp Phe Ala

145 150 155 160

Gly Pro Ala Ile His Gly Ser Ala Val Phe Gly Tyr Glu Gly Trp Leu

165 170 175

Ala Gly Tyr Gln Met Thr Phe Asp Ser Ala Lys Ser Lys Leu Thr Arg

180 185 190

Asn Asn Phe Ala Val Gly Tyr Arg Thr Gly Asp Phe Gln Leu His Thr

195 200 205

Asn Val Asn Asp Gly Thr Glu Phe Gly Gly Ser Ile Tyr Gln Lys Val

210 215 220

Cys Glu Asp Leu Asp Thr Ser Val Asn Leu Ala Trp Thr Ser Gly Thr

225 230 235 240

Asn Cys Thr Arg Phe Gly Ile Ala Ala Lys Tyr Gln Leu Asp Pro Thr

245 250 255

Ala Ser Ile Ser Ala Lys Val Asn Asn Ser Ser Leu Ile Gly Val Gly

260 265 270

Tyr Thr Gln Thr Leu Arg Pro Gly Val Lys Leu Thr Leu Ser Ala Leu

275 280 285

Val Asp Gly Lys Ser Ile Asn Ala Gly Gly His Lys Val Gly Ser Pro

290 295 300

Trp Ser Trp Arg Leu Asn Pro Ala Glu Arg Asn Leu Trp Glu Trp Ile

305 310 315 320

Ser Glu Asp Leu Ala Leu Ile Tyr Phe His Cys Asp Gln Gln Gln Ala

325 330 335

Phe Phe Pro Pro Glu Asp Asp Gln Asn Lys Gly

340 345

<210>19

<211>339

<212>PRT

<213> Human (Homo sapiens)

<220>

<221> Annexin II

<222>(1)..(339)

<223> December 6, 2002 Registration number: P07355

<400>19

Met Ser Thr Val His Glu Ile Leu Cys Lys Leu Ser Leu Glu Gly Asp

1 5 10 15

His Ser Thr Pro Pro Ser Ala Tyr Gly Ser Val Lys Ala Tyr Thr Asn

20 25 30

Phe Asp Ala Glu Arg Asp Ala Leu Asn Ile Glu Thr Ala Ile Lys Thr

35 40 45

Lys Gly Val Asp Glu Val Thr Ile Val Asn Ile Leu Thr Asn Arg Ser

50 55 60

Asn Ala Gln Arg Gln Asp Ile Ala Phe Ala Tyr Gln Arg Arg Thr Lys

65 70 75 80

Lys Glu Leu Ala Ser Ala Leu Lys Ser Ala Leu Ser Gly His Leu Glu

85 90 95

Thr Val Ile Leu Gly Leu Leu Lys Thr Pro Ala Gln Tyr Asp Ala Ser

100 105 110

Glu Leu Lys Ala Ser Met Lys Gly Leu Gly Thr Asp Glu Asp Ser Leu

115 120 125

Ile Glu Ile Ile Cys Ser Arg Thr Asn Gln Glu Leu Gln Glu Ile Asn

130 135 140

Arg Val Tyr Lys Glu Met Tyr Lys Thr Asp Leu Glu Lys Asp Ile Ile

145 150 155 160

Ser Asp Thr Ser Gly Asp Phe Arg Lys Leu Met Val Ala Leu Ala Lys

165 170 175

Gly Arg Arg Ala Glu Asp Gly Ser Val Ile Asp Tyr Glu Leu Ile Asp

180 185 190

Gln Asp Ala Arg Asp Leu Tyr Asp Ala Gly Val Lys Arg Lys Gly Thr

195 200 205

Asp Val Pro Lys Trp Ile Ser Ile Met Thr Glu Arg Ser Val Pro His

210 215 220

Leu Gln Lys Val Phe Asp Arg Tyr Lys Ser Tyr Ser Pro Tyr Asp Met

225 230 235 240

Leu Glu Ser Ile Arg Lys Glu Val Lys Gly Asp Leu Glu Asn Ala Phe

245 250 255

Leu Asn Leu Val Gln Cys Ile Gln Asn Lys Pro Leu Tyr Phe Ala Asp

260 265 270

Arg Leu Tyr Asp Ser Met Lys Gly Lys Gly Thr Arg Asp Lys Val Leu

275 280 285

Ile Arg Ile Met Val Ser Arg Ser Glu Val Asp Met Leu Lys Ile Arg

290 295 300

Ser Glu Phe Lys Arg Lys Tyr Gly Lys Ser Leu Tyr Tyr Tyr Ile Gln

305 310 315 320

Gln Asp Thr Lys Gly Asp Tyr Gln Lys Ala Leu Leu Tyr Leu Cys Gly

325 330 335

Gly Asp Asp

<210>20

<211>418

<212>PRT

<213> Human (Homo sapiens)

<220>

<221> collagen-binding protein 2

<222>(1)..(418)

<223> December 6, 2002 Registration number: P50454

<400>20

Met Arg Ser Leu Leu Leu Leu Ser Ala Phe Cys Leu Leu Glu Ala Ala

1 5 10 15

Leu Ala Ala Glu Val Lys Lys Pro Ala Ala Ala Ala Ala Pro Gly Thr

20 25 30

Ala Glu Lys Leu Ser Pro Lys Ala Ala Thr Leu Ala Glu Arg Ser Ala

35 40 45

Gly Leu Ala Phe Ser Leu Tyr Gln Ala Met Ala Lys Asp Gln Ala Val

50 55 60

Glu Asn Ile Leu Val Ser Pro Val Val Val Ala Ser Ser Leu Gly Leu

65 70 75 80

Val Ser Leu Gly Gly Lys Ala Thr Thr Ala Ser Gln Ala Lys Ala Val

85 90 95

Leu Ser Ala Glu Gln Leu Arg Asp Glu Glu Val His Ala Gly Leu Gly

100 105 110

Glu Leu Leu Arg Ser Leu Ser Ser Asn Ser Thr Ala Arg Asn Val Thr Trp

115 120 125

Lys Leu Gly Ser Arg Leu Tyr Gly Pro Ser Ser Val Ser Phe Ala Asp

130 135 140

Asp Phe Val Arg Ser Ser Lys Gln His Tyr Asn Cys Glu His Ser Lys

145 150 155 160

Ile Asn Phe Arg Asp Lys Arg Ser Ala Leu Gln Ser Ile Asn Glu Trp

165 170 175

Ala Ala Gln Thr Thr Asp Gly Lys Leu Pro Glu Val Thr Lys Asp Val

180 185 190

Glu Arg Thr Asp Gly Ala Leu Leu Val Asn Ala Met Phe Phe Lys Pro

195 200 205

His Trp Asp Glu Lys Phe His His Lys Met Val Asp Asn Arg Gly Phe

210 215 220

Met Val Thr Arg Ser Tyr Thr Val Gly Val Met Met Met His Arg Thr

225 230 235 240

Gly Leu Tyr Asn Tyr Tyr Asp Asp Glu Lys Glu Lys Leu Gln Ile Val

245 250 255

Glu Met Pro Leu Ala His Lys Leu Ser Ser Leu Ile Ile Leu Met Pro

260 265 270

His His Val Glu Pro Leu Glu Arg Leu Glu Lys Leu Leu Thr Lys Glu

275 280 285

Gln Leu Lys Ile Trp Met Gly Lys Met Gln Lys Lys Ala Val Ala Ile

290 295 300

Ser Leu Pro Lys Gly Val Val Glu Val Thr His Asp Leu Gln Lys His

305 310 315 320

Leu Ala Gly Leu Gly Leu Thr Glu Ala Ile Asp Lys Asn Lys Ala Asp

325 330 335

Leu Ser Arg Met Ser Gly Lys Lys Asp Leu Tyr Leu Ala Ser Val Phe

340 345 350

His Ala Thr Ala Phe Glu Leu Asp Thr Asp Gly Asn Pro Phe Asp Gln

355 360 365

Asp Ile Tyr Gly Arg Glu Glu Leu Arg Ser Pro Lys Leu Phe Tyr Ala

370 375 380

Asp His Pro Phe Ile Phe Leu Val Arg Asp Thr Gln Ser Gly Ser Leu

385 390 395 400

Leu Phe Ile Gly Arg Leu Val Arg Pro Lys Gly Asp Lys Met Arg Asp

405 410 415

Glu Leu

<210>21

<211>166

<212>PRT

<213> Human (Homo sapiens)

<220>

<221> Non-muscle isoform Cofilin

<222>(1)..(166)

<223> December 8, 2002 Registration number: P23528

<400>21

Met Ala Ser Gly Val Ala Val Ser Asp Gly Val Ile Lys Val Phe Asn

1 5 10 15

Asp Met Lys Val Arg Lys Ser Ser Thr Pro Glu Glu Val Lys Lys Arg

20 25 30

Lys Lys Ala Val Leu Phe Cys Leu Ser Glu Asp Lys Lys Asn Ile Ile

35 40 45

Leu Glu Glu Gly Lys Glu Ile Leu Val Gly Asp Val Gly Gln Thr Val

50 55 60

Asp Asp Pro Tyr Ala Thr Phe Val Lys Met Leu Pro Asp Lys Asp Cys

65 70 75 80

Arg Tyr Ala Leu Tyr Asp Ala Thr Tyr Glu Thr Lys Glu Ser Lys Lys

85 90 95

Glu Asp Leu Val Phe Ile Phe Trp Ala Pro Glu Ser Ala Pro Leu Lys

100 105 110

Ser Lys Met Ile Tyr Ala Ser Ser Lys Asp Ala Ile Lys Lys Lys Leu

115 120 125

Thr Gly Ile Lys His Glu Leu Gln Ala Asn Cys Tyr Glu Glu Val Lys

130 135 140

Asp Arg Cys Thr Leu Ala Glu Lys Leu Gly Gly Ser Ala Val Ile Ser

145 150 155 160

Leu Glu Gly Lys Pro Leu

165

<210>22

<211>165

<212>PRT

<213> Human (Homo sapiens)

<220>

<221> Peptidylproline cis-trans isomerase A

<222>(1)..(165)

<223> December 9, 2002 Registration number: P05092

<400>22

Met Val Asn Pro Thr Val Phe Phe Asp Ile Ala Val Asp Gly Glu Pro

1 5 10 15

Leu Gly Arg Val Ser Phe Glu Leu Phe Ala Asp Lys Val Pro Lys Thr

20 25 30

Ala Glu Asn Phe Arg Ala Leu Ser Thr Gly Glu Lys Gly Phe Gly Tyr

35 40 45

Lys Gly Ser Cys Phe His Arg Ile Ile Pro Gly Phe Met Cys Gln Gly

50 55 60

Gly Asp Phe Thr Arg His Asn Gly Thr Gly Gly Lys Ser Ile Tyr Gly

65 70 75 80

Glu Lys Phe Glu Asp Glu Asn Phe Ile Leu Lys His Thr Gly Pro Gly

85 90 95

Ile Leu Ser Met Ala Asn Ala Gly Pro Asn Thr Asn Gly Ser Gln Phe

100 105 110

Phe Ile Cys Thr Ala Lys Thr Glu Trp Leu Asp Gly Lys His Val Val

115 120 125

Phe Gly Lys Val Lys Glu Gly Met Asn Ile Val Glu Ala Met Glu Arg

130 135 140

Phe Gly Ser Arg Asn Gly Lys Thr Ser Lys Lys Ile Thr Ile Ala Asp

145 150 155 160

Cys Gly Gln Leu Glu

165

<210>23

<211>638

<212>PRT

<213> Human (Homo sapiens)

<220>

<221> Cytoplasmic dynein middle chain

<222>(1)..(638)

<223> December 9, 2002 Registration number: Q13409

<400>23

Met Ser Asp Lys Ser Glu Leu Lys Ala Glu Leu Glu Arg Lys Lys Gln

1 5 10 15

Arg Leu Ala Gln Ile Arg Glu Glu Lys Lys Arg Lys Glu Glu Glu Arg

20 25 30

Lys Lys Lys Glu Thr Asp Gln Lys Lys Glu Ala Val Ala Pro Val Gln

35 40 45

Glu Glu Ser Asp Leu Glu Lys Lys Arg Arg Glu Ala Glu Ala Leu Leu

50 55 60

Gln Ser Met Gly Leu Thr Pro Glu Ser Pro Ile Val Phe Ser Glu Tyr

65 70 75 80

Trp Val Pro Pro Pro Met Ser Pro Ser Ser Lys Ser Val Ser Thr Pro

85 90 95

Ser Glu Ala Gly Ser Gln Asp Ser Gly Asp Gly Ala Val Gly Ser Arg

100 105 110

Thr Leu His Trp Asp Thr Asp Pro Ser Val Leu Gln Leu His Ser Asp

115 120 125

Ser Asp Leu Gly Arg Gly Pro Ile Lys Leu Gly Met Ala Lys Ile Thr

130 135 140

Gln Val Asp Phe Pro Pro Arg Glu Ile Val Thr Tyr Thr Lys Glu Thr

145 150 155 160

Gln Thr Pro Val Met Ala Gln Pro Lys Glu Asp Glu Glu Glu Asp Asp

165 170 175

Asp Val Val Ala Pro Lys Pro Pro Ile Glu Pro Glu Glu Glu Lys Thr

180 185 190

Leu Lys Lys Asp Glu Glu Asn Asp Ser Lys Ala Pro Pro His Glu Leu

195 200 205

Thr Glu Glu Glu Lys Gln Gln Ile Leu His Ser Glu Glu Phe Leu Ser

210 215 220

Phe Phe Asp His Ser Thr Arg Ile Val Glu Arg Ala Leu Ser Glu Gln

225 230 235 240

Ile Asn Ile Phe Phe Asp Tyr Ser Gly Arg Asp Leu Glu Asp Lys Glu

245 250 255

Gly Glu Ile Gln Ala Gly Ala Lys Leu Ser Leu Asn Arg Gln Phe Phe

260 265 270

Asp Glu Arg Trp Ser Lys His Arg Val Val Ser Cys Leu Asp Trp Ser

275 280 285

Ser Gln Tyr Pro Glu Leu Leu Val Ala Ser Tyr Asn Asn Asn Glu Asp

290 295 300

Ala Pro His Glu Pro Asp Gly Val Ala Leu Val Trp Asn Met Lys Tyr

305 310 315 320

Lys Lys Thr Thr Pro Glu Tyr Val Phe His Cys Gln Ser Ala Val Met

325 330 335

Ser Ala Thr Phe Ala Lys Phe His Pro Asn Leu Val Val Gly Gly Thr

340 345 350

Tyr Ser Gly Gln Ile Val Leu Trp Asp Asn Arg Ser Asn Lys Arg Thr

355 360 365

Pro Val Gln Arg Thr Pro Leu Ser Ala Ala Ala His Thr His Pro Val

370 375 380

Tyr Cys Val Asn Val Val Gly Thr Gln Asn Ala His Asn Leu Ile Ser

385 390 395 400

Ile Ser Thr Asp Gly Lys Ile Cys Ser Trp Ser Leu Asp Met Leu Ser

405 410 415

His Pro Gln Asp Ser Met Glu Leu Val His Lys Gln Ser Lys Ala Val

420 425 430

Ala Val Thr Ser Met Ser Phe Pro Val Gly Asp Val Asn Asn Phe Val

435 440 445

Val Gly Ser Glu Glu Gly Ser Val Tyr Thr Ala Cys Arg His Gly Ser

450 455 460

Lys Ala Gly Ile Ser Glu Met Phe Glu Gly His Gln Gly Pro Ile Thr

465 470 475 480

Gly Ile His Cys His Ala Ala Val Gly Ala Val Asp Phe Ser His Leu

485 490 495

Phe Val Thr Ser Ser Phe Asp Trp Thr Val Lys Leu Trp Thr Thr Lys

500 505 510

Asn Asn Lys Pro Leu Tyr Ser Phe Glu Asp Asn Ala Asp Tyr Val Tyr

515 520 525

Asp Val Met Trp Ser Pro Thr His Pro Ala Leu Phe Ala Cys Val Asp

530 535 540

Gly Met Gly Arg Leu Asp Leu Trp Asn Leu Asn Asn Asp Thr Glu Val

545 550 555 560

Pro Thr Ala Ser Ile Ser Val Glu Gly Asn Pro Ala Leu Asn Arg Val

565 570 575

Arg Trp Thr His Ser Gly Arg Glu Ile Ala Val Gly Asp Ser Glu Gly

580 585 590

Gln Ile Val Ile Tyr Asp Val Gly Glu Gln Ile Ala Val Pro Arg Asn

595 600 605

Asp Glu Trp Ala Arg Phe Gly Arg Thr Leu Ala Glu Ile Asn Ala Asn

610 615 620

Arg Ala Asp Ala Glu Glu Glu Ala Ala Thr Arg Ile Pro Ala

625 630 635

<210>24

<211>328

<212>PRT

<213> Human (Homo sapiens)

<220>

<221> Mitochondrial Delta 3,5-Delta 2,4-dienol-CoA isomerase precursor

<222>(1)..(328)

<223> December 9, 2002 Registration number: Q13011

<400>24

Met Ala Ala Gly Ile Val Ala Ser Arg Arg Leu Arg Asp Leu Leu Thr

1 5 10 15

Arg Arg Leu Thr Gly Ser Asn Tyr Pro Gly Leu Ser Ile Ser Leu Arg

20 25 30

Leu Thr Gly Ser Ser Ala Gln Glu Glu Ala Ser Gly Val Ala Leu Gly

35 40 45

Glu Ala Pro Asp His Ser Tyr Glu Ser Leu Arg Val Thr Ser Ala Gln

50 55 60

Lys His Val Leu His Val Gln Leu Asn Arg Pro Asn Lys Arg Asn Ala

65 70 75 80

Met Asn Lys Val Phe Trp Arg Glu Met Val Glu Cys Phe Asn Lys Ile

85 90 95

Ser Arg Asp Ala Asp Cys Arg Ala Val Val Ile Ser Gly Ala Gly Lys

100 105 110

Met Phe Thr Ala Gly Ile Asp Leu Met Asp Met Ala Ser Asp Ile Leu

115 120 125

Gln Pro Lys Gly Asp Asp Val Ala Arg Ile Ser Trp Tyr Leu Arg Asp

130 135 140

Ile Ile Thr Arg Tyr Gln Glu Thr Phe Asn Val Ile Glu Arg Cys Pro

145 150 155 160

Lys Pro Val Ile Ala Ala Val His Gly Gly Cys Ile Gly Gly Gly Val

165 170 175

Asp Leu Val Thr Ala Cys Asp Ile Arg Tyr Cys Ala Gln Asp Ala Phe

180 185 190

Phe Gln Val Lys Glu Val Asp Val Gly Leu Ala Ala Asp Val Gly Thr

195 200 205

Leu Glu Arg Leu Pro Lys Val Ile Gly Asn Gln Ser Leu Val Asn Glu

210 215 220

Leu Ala Phe Thr Ala His Lys Met Met Ala Asp Glu Ala Leu Asp Ser

225 230 235 240

Gly Leu Val Ser Arg Val Phe Pro Asp Lys Glu Val Met Leu Asp Ala

245 250 255

Ala Leu Pro Leu Ala Pro Glu Ile Ser Ser Lys Thr Thr Val Leu Val

260 265 270

Gln Ser Thr Lys Val Asn Leu Leu Tyr Ser Arg Asp His Ser Val Ala

275 280 285

Glu Ser Leu Asn Tyr Val Ala Ser Trp Asn Met Ser Met Leu Gln Thr

290 295 300

Gln Asp Leu Val Lys Ser Val Gln Pro Thr Thr Glu Asn Lys Glu Leu

305 310 315 320

Lys Thr Val Thr Phe Ser Lys Leu

325

<210>25

<211>1657

<212>PRT

<213> Human (Homo sapiens)

<220>

<221> Ras-like GTPase activator protein IQGAP1

<222>(1)..(1657)

<223> December 9, 2002 Registration number: P46940

<400>25

Met Ser Ala Ala Asp Glu Val Asp Gly Leu Gly Val Ala Arg Pro His

1 5 10 15

Tyr Gly Ser Val Leu Asp Asn Glu Arg Leu Thr Ala Glu Glu Met Asp

20 25 30

Glu Arg Arg Arg Gln Asn Val Ala Tyr Glu Tyr Leu Cys His Leu Glu

35 40 45

Glu Ala Lys Arg Trp Met Glu Ala Cys Leu Gly Glu Asp Leu Pro Pro

50 55 60

Thr Thr Glu Leu Glu Glu Gly Leu Arg Asn Gly Val Tyr Leu Ala Lys

65 70 75 80

Leu Gly Asn Phe Phe Ser Pro Lys Val Val Ser Leu Lys Lys Ile Tyr

85 90 95

Asp Arg Glu Gln Thr Arg Tyr Lys Ala Thr Gly Leu His Phe Arg His

100 105 110

Thr Asp Asn Val Ile Gln Trp Leu Asn Ala Met Asp Glu Ile Gly Leu

115 120 125

Pro Lys Ile Phe Tyr Pro Glu Thr Thr Asp Ile Tyr Asp Arg Lys Asn

130 135 140

Met Pro Arg Cys Ile Tyr Cys Ile His Ala Leu Ser Leu Tyr Leu Phe

145 150 155 160

Lys Leu Gly Leu Ala Pro Gln Ile Gln Asp Leu Tyr Gly Lys Val Asp

165 170 175

Phe Thr Glu Glu Glu Ile Asn Asn Met Lys Thr Glu Leu Glu Lys Tyr

180 185 190

Gly Ile Gln Met Pro Ala Phe Ser Lys Ile Gly Gly Ile Leu Ala Asn

195 200 205

Glu Leu Ser Val Asp Glu Ala Ala Leu His Ala Ala Val Ile Ala Ile

210 215 220

Asn Glu Ala Ile Asp Arg Arg Ile Pro Ala Asp Thr Phe Ala Ala Leu

225 230 235 240

Lys Asn Pro Asn Ala Met Leu Val Asn Leu Glu Glu Pro Leu Ala Ser

245 250 255

Thr Tyr Gln Asp Ile Leu Tyr Gln Ala Lys Gln Asp Lys Met Thr Asn

260 265 270

Ala Lys Asn Arg Thr Glu Asn Ser Glu Arg Glu Arg Asp Val Tyr Glu

275 280 285

Glu Leu Leu Thr Gln Ala Glu Ile Gln Gly Asn Ile Asn Lys Val Asn

290 295 300

Thr Phe Ser Ala Leu Ala Asn Ile Asp Leu Ala Leu Glu Gln Gly Asp

305 310 315 320

Ala Leu Ala Leu Phe Arg Ala Leu Gln Ser Pro Ala Leu Gly Leu Arg

325 330 335

Gly Leu Gln Gln Gln Asn Ser Asp Trp Tyr Leu Lys Gln Leu Leu Ser

340 345 350

Asp Lys Gln Gln Lys Arg Gln Ser Gly Gln Thr Asp Pro Leu Gln Lys

355 360 365

Glu Glu Leu Gln Ser Gly Val Asp Ala Ala Asn Ser Ala Ala Gln Gln

370 375 380

Tyr Gln Arg Arg Leu Ala Ala Val Ala Leu Ile Asn Ala Ala Ile Gln

385 390 395 400

Lys Gly Val Ala Glu Lys Thr Val Leu Glu Leu Met Asn Pro Glu Ala

405 410 415

Gln Leu Pro Gln Val Tyr Pro Phe Ala Ala Asp Leu Tyr Gln Lys Glu

420 425 430

Leu Ala Thr Leu Gln Arg Gln Ser Pro Glu His Asn Leu Thr His Pro

435 440 445

Glu Leu Ser Val Ala Val Glu Met Leu Ser Ser Val Ala Leu Ile Asn

450 455 460

Arg Ala Leu Glu Ser Gly Asp Val Asn Thr Val Trp Lys Gln Leu Ser

465 470 475 480

Ser Ser Val Thr Gly Leu Thr Asn Ile Glu Glu Glu Asn Cys Gln Arg

485 490 495

Tyr Leu Asp Glu Leu Met Lys Leu Lys Ala Gln Ala His Ala Glu Asn

500 505 510

Asn Glu Phe Ile Thr Trp Asn Asp Ile Gln Ala Cys Val Asp His Val

515 520 525

Asn Leu Val Val Gln Glu Glu His Glu Arg Ile Leu Ala Ile Gly Leu

530 535 540

Ile Asn Glu Ala Leu Asp Glu Gly Asp Ala Gln Lys Thr Leu Gln Ala

545 550 555 560

Leu Gln Ile Pro Ala Ala Lys Leu Glu Gly Val Leu Ala Glu Val Ala

565 570 575

Gln His Tyr Gln Asp Thr Leu Ile Arg Ala Lys Arg Glu Lys Ala Gln

580 585 590

Glu Ile Gln Asp Glu Ser Ala Val Leu Trp Leu Asp Glu Ile Gln Gly

595 600 605

Gly Ile Trp Gln Ser Asn Lys Asp Thr Gln Glu Ala Gln Lys Phe Ala

610 615 620

Leu Gly Ile Phe Ala Ile Asn Glu Ala Val Glu Ser Gly Asp Val Gly

625 630 635 640

Lys Thr Leu Ser Ala Leu Arg Ser Pro Asp Val Gly Leu Tyr Gly Val

645 650 655

Ile Pro Glu Cys Gly Glu Thr Tyr His Ser Asp Leu Ala Glu Ala Lys

660 665 670

Lys Lys Lys Leu Ala Val Gly Asp Asn Asn Ser Lys Trp Val Lys His

675 680 685

Trp Val Lys Gly Gly Tyr Tyr Tyr Tyr His Asn Leu Glu Thr Gln Glu

690 695 700

Gly Gly Trp Asp Glu Pro Pro Asn Phe Val Gln Asn Ser Met Gln Leu

705 710 715 720

Ser Arg Glu Glu Ile Gln Ser Ser Ile Ser Gly Val Thr Ala Ala Tyr

725 730 735

Asn Arg Glu Gln Leu Trp Leu Ala Asn Glu Gly Leu Ile Thr Arg Leu

740 745 750

Gln Ala Arg Cys Arg Gly Tyr Leu Val Arg Gln Glu Phe Arg Ser Arg

755 760 765

Met Asn Phe Leu Lys Lys Gln Ile Pro Ala Ile Thr Cys Ile Gln Ser

770 775 780

Gln Trp Arg Gly Tyr Lys Gln Lys Lys Ala Tyr Gln Asp Arg Leu Ala

785 790 795 800

Tyr Leu Arg Ser His Lys Asp Glu Val Val Lys Ile Gln Ser Leu Ala

805 810 815

Arg Met His Gln Ala Arg Lys Arg Tyr Arg Asp Arg Leu Gln Tyr Phe

820 825 830

Arg Asp His Ile Asn Asp Ile Ile Lys Ile Gln Ala Phe Ile Arg Ala

835 840 845

Asn Lys Ala Arg Asp Asp Tyr Lys Thr Leu Ile Asn Ala Glu Asp Pro

850 855 860

Pro Met Val Val Val Arg Lys Phe Val His Leu Leu Asp Gln Ser Asp

865 870 875 880

Gln Asp Phe Gln Glu Glu Leu Asp Leu Met Lys Met Arg Glu Glu Val

885 890 895

Ile Thr Leu Ile Arg Ser Asn Gln Gln Leu Glu Asn Asp Leu Asn Leu

900 905 910

Met Asp Ile Lys Ile Gly Leu Leu Val Lys Asn Lys Ile Thr Leu Gln

915 920 925

Asp Val Val Ser His Ser Lys Lys Leu Thr Lys Lys Asn Lys Glu Gln

930 935 940

Leu Ser Asp Met Met Met Ile Asn Lys Gln Lys Gly Gly Leu Lys Ala

945 950 955 960

Leu Ser Lys Glu Lys Arg Glu Lys Leu Glu Ala Tyr Gln His Leu Phe

965 970 975

Tyr Leu Leu Gln Thr Asn Pro Thr Tyr Leu Ala Lys Leu Ile Phe Gln

980 985 990

Met Pro Gln Asn Lys Ser Thr Lys Phe Met Asp Ser Val Ile Phe Thr

995 1000 1005

Leu Tyr Asn Tyr Ala Ser Asn Gln Arg Glu Glu Tyr Leu Leu Leu

1010 1015 1020

Arg Leu Phe Lys Thr Ala Leu Gln Glu Glu Ile Lys Ser Lys Val

1025 1030 1035

Asp Gln Ile Gln Glu Ile Val Thr Gly Asn Pro Thr Val Ile Lys

1040 1045 1050

Met Val Val Ser Phe Asn Arg Gly Ala Arg Gly Gln Asn Ala Leu

1055 1060 1065

Arg Gln Ile Leu Ala Pro Val Val Lys Glu Ile Met Asp Asp Lys

1070 1075 1080

Ser Leu Asn Ile Lys Thr Asp Pro Val Asp Ile Tyr Lys Ser Trp

1085 1090 1095

Val Asn Gln Met Glu Ser Gln Thr Gly Glu Ala Ser Lys Leu Pro

1100 1105 1110

Tyr Asp Val Thr Pro Glu Gln Ala Leu Ala His Glu Glu Val Lys

1115 1120 1125

Thr Arg Leu Asp Ser Ser Ile Arg Asn Met Arg Ala Val Thr Asp

1130 1135 1140

Lys Phe Leu Ser Ala Ile Val Ser Ser Val Asp Lys Ile Pro Tyr

1145 1150 1155

Gly Met Arg Phe Ile Ala Lys Val Leu Lys Asp Ser Leu His Glu

1160 1165 1170

Lys Phe Pro Asp Ala Gly Glu Asp Glu Leu Leu Lys Ile Ile Gly

1175 1180 1185

Asn Leu Leu Tyr Tyr Arg Tyr Met Asn Pro Ala Ile Val Ala Pro

1190 1195 1200

Asp Ala Phe Asp Ile Ile Asp Leu Ser Ala Gly Gly Gln Leu Thr

1205 1210 1215

Thr Asp Gln Arg Arg Asn Leu Gly Ser Ile Ala Lys Met Leu Gln

1220 1225 1230

His Ala Ala Ser Asn Lys Met Phe Leu Gly Asp Asn Ala His Leu

1235 1240 1245

Ser Ile Ile Asn Glu Tyr Leu Ser Gln Ser Tyr Gln Lys Phe Arg

1250 1255 1260

Arg Phe Phe Gln Thr Ala Cys Asp Val Pro Glu Leu Gln Asp Lys

1265 1270 1275

Phe Asn Val Asp Glu Tyr Ser Asp Leu Val Thr Leu Thr Lys Pro

1280 1285 1290

Val Ile Tyr Ile Ser Ile Gly Glu Ile Ile Asn Thr His Thr Leu

1295 1300 1305

Leu Leu Asp His Gln Asp Ala Ile Ala Pro Glu His Asn Asp Pro

1310 1315 1320

Ile His Glu Leu Leu Asp Asp Leu Gly Glu Val Pro Thr Ile Glu

1325 1330 1335

Ser Leu Ile Gly Glu Ser Ser Ser Gly Asn Leu Asn Asp Pro Asn Lys

1340 1345 1350

Glu Ala Leu Ala Lys Thr Glu Val Ser Leu Thr Leu Thr Asn Lys

1355 1360 1365

Phe Asp Val Pro Gly Asp Glu Asn Ala Glu Met Asp Ala Arg Thr

1370 1375 1380

Ile Leu Leu Asn Thr Lys Arg Leu Ile Val Asp Val Ile Arg Phe

1385 1390 1395

Gln Pro Gly Glu Thr Leu Thr Glu Ile Leu Glu Thr Pro Ala Thr

1400 1405 1410

Ser Glu Gln Glu Ala Glu His Gln Arg Ala Met Gln Arg Arg Ala

1415 1420 1425

Ile Arg Asp Ala Lys Thr Pro Asp Lys Met Lys Lys Ser Lys Ser

1430 1435 1440

Val Lys Glu Asp Ser Asn Leu Thr Leu Gln Glu Lys Lys Glu Lys

1445 1450 1455

Ile Gln Thr Gly Leu Lys Lys Leu Thr Glu Leu Gly Thr Val Asp

1460 1465 1470

Pro Lys Asn Lys Tyr Gln Glu Leu Ile Asn Asp Ile Ala Arg Asp

1475 1480 1485

Ile Arg Asn Gln Arg Arg Tyr Arg Gln Arg Arg Lys Ala Glu Leu

1490 1495 1500

Val Lys Leu Gln Gln Thr Tyr Ala Ala Leu Asn Ser Lys Ala Thr

1505 1510 1515

Phe Tyr Gly Glu Gln Val Asp Tyr Tyr Lys Ser Tyr Ile Lys Thr

1520 1525 1530

Cys Leu Asp Asn Leu Ala Ser Lys Gly Lys Val Ser Lys Lys Pro

1535 1540 1545

Arg Glu Met Lys Gly Lys Lys Ser Lys Lys Ile Ser Leu Lys Tyr

1550 1555 1560

Thr Ala Ala Arg Leu His Glu Lys Gly Val Leu Leu Glu Ile Glu

1565 1570 1575

Asp Leu Gln Val Asn Gln Phe Lys Asn Val Ile Phe Glu Ile Ser

1580 1585 1590

Pro Thr Glu Glu Val Gly Asp Phe Glu Val Lys Ala Lys Phe Met

1595 1600 1605

Gly Val Gln Met Glu Thr Phe Met Leu His Tyr Gln Asp Leu Leu

1610 1615 1620

Gln Leu Gln Tyr Glu Gly Val Ala Val Met Lys Leu Phe Asp Arg

1625 1630 1635

Ala Lys Val Asn Val Asn Leu Leu Ile Phe Leu Leu Asn Lys Lys

1640 1645 1650

Phe Tyr Gly Lys

1655

<210>26

<211>627

<212>PRT

<213> Human (Homo sapiens)

<220>

<221> L-plastin (lymphocyte cytoplasmic protein 1)

<222>(1)..(627)

<223> December 9, 2002 Registration number: P13796

<400>26

Met Ala Arg Gly Ser Val Ser Asp Glu Glu Met Met Glu Leu Arg Glu

1 5 10 15

Ala Phe Ala Lys Val Asp Thr Asp Gly Asn Gly Tyr Ile Ser Phe Asn

20 25 30

Glu Leu Asn Asp Leu Phe Lys Ala Ala Cys Leu Pro Leu Pro Gly Tyr

35 40 45

Arg Val Arg Glu Ile Thr Glu Asn Leu Met Ala Thr Gly Asp Leu Asp

50 55 60

Gln Asp Gly Arg Ile Ser Phe Asp Glu Phe Ile Lys Ile Phe His Gly

65 70 75 80

Leu Lys Ser Thr Asp Val Ala Lys Thr Phe Arg Lys Ala Ile Asn Lys

85 90 95

Lys Glu Gly Ile Cys Ala Ile Gly Gly Thr Ser Glu Gln Ser Ser Val

100 105 110

Gly Thr Gln His Ser Tyr Ser Glu Glu Glu Lys Tyr Ala Phe Val Asn

115 120 125

Trp Ile Asn Lys Ala Leu Glu Asn Asp Pro Asp Cys Arg His Val Ile

130 135 140

Pro Met Asn Pro Asn Thr Asn Asp Leu Phe Asn Ala Val Gly Asp Gly

145 150 155 160

Ile Val Leu Cys Lys Met Ile Asn Leu Ser Val Pro Asp Thr Ile Asp

165 170 175

Glu Arg Thr Ile Asn Lys Lys Lys Leu Thr Pro Phe Thr Ile Gln Glu

180 185 190

Asn Leu Asn Leu Ala Leu Asn Ser Ala Ser Ala Ile Gly Cys His Val

195 200 205

Val Asn Ile Gly Ala Glu Asp Leu Lys Glu Gly Lys Pro Tyr Leu Val

210 215 220

Leu Gly Leu Leu Trp Gln Val Ile Lys Ile Gly Leu Phe Ala Asp Ile

225 230 235 240

Glu Leu Ser Arg Asn Glu Ala Leu Ile Ala Leu Leu Arg Glu Gly Glu

245 250 255

Ser Leu Glu Asp Leu Met Lys Leu Ser Pro Glu Glu Leu Leu Leu Arg

260 265 270

Trp Ala Asn Tyr His Leu Glu Asn Ala Gly Cys Asn Lys Ile Gly Asn

275 280 285

Phe Ser Thr Asp Ile Lys Asp Ser Lys Ala Tyr Tyr His Leu Leu Glu

290 295 300

Gln Val Ala Pro Lys Gly Asp Glu Glu Gly Val Pro Ala Val Val Ile

305 310 315 320

Asp Met Ser Gly Leu Arg Glu Lys Asp Asp Ile Gln Arg Ala Glu Cys

325 330 335

Met Leu Gln Gln Ala Glu Arg Leu Gly Cys Arg Gln Phe Val Thr Ala

340 345 350

Thr Asp Val Val Arg Gly Asn Pro Lys Leu Asn Leu Ala Phe Ile Ala

355 360 365

Asn Leu Phe Asn Arg Tyr Pro Ala Leu His Lys Pro Glu Asn Gln Asp

370 375 380

Ile Asp Trp Gly Ala Leu Glu Gly Glu Thr Arg Glu Glu Arg Thr Phe

385 390 395 400

Arg Asn Trp Met Asn Ser Leu Gly Val Asn Pro Arg Val Asn His Leu

405 410 415

Tyr Ser Asp Leu Ser Asp Ala Leu Val Ile Phe Gln Leu Tyr Glu Lys

420 425 430

Ile Lys Val Pro Val Asp Trp Asn Arg Val Asn Lys Pro Pro Tyr Pro

435 440 445

Lys Leu Gly Gly Asn Met Lys Lys Leu Glu Asn Cys Asn Tyr Ala Val

450 455 460

Glu Leu Gly Lys Asn Gln Ala Lys Phe Ser Leu Val Gly Ile Gly Gly

465 470 475 480

Gln Asp Leu Asn Glu Gly Asn Arg Thr Leu Thr Leu Ala Leu Ile Trp

485 490 495

Gln Leu Met Arg Arg Tyr Thr Leu Asn Ile Leu Glu Glu Ile Gly Gly

500 505 510

Gly Gln Lys Val Asn Asp Asp Ile Ile Val Asn Trp Val Asn Glu Thr

515 520 525

Leu Arg Glu Ala Glu Lys Ser Ser Ser Ile Ser Ser Phe Lys Asp Pro

530 535 540

Lys Ile Ser Thr Ser Leu Pro Val Leu Asp Leu Ile Asp Ala Ile Gln

545 550 555 560

Pro Gly Ser Ile Asn Tyr Asp Leu Leu Lys Thr Glu Asn Leu Asn Asp

565 570 575

Asp Glu Lys Leu Asn Asn Ala Lys Tyr Ala Ile Ser Met Ala Arg Lys

580 585 590

Ile Gly Ala Arg Val Tyr Ala Leu Pro Glu Asp Leu Val Glu Val Asn

595 600 605

Pro Lys Met Val Met Thr Val Phe Ala Cys Leu Met Gly Lys Gly Met

610 615 620

Lys Arg Val

625

<210>27

<211>216

<212>PRT

<213> Human (Homo sapiens)

<220>

<221> GTP-binding nucleoprotein RAN

<222>(1)..(216)

<223> December 9, 2002 Registration number: P17080

<400>27

Met Ala Ala Gln Gly Glu Pro Gln Val Gln Phe Lys Leu Val Leu Val

1 5 10 15

Gly Asp Gly Gly Thr Gly Lys Thr Thr Phe Val Lys Arg His Leu Thr

20 25 30

Gly Glu Phe Glu Lys Lys Tyr Val Ala Thr Leu Gly Val Glu Val His

35 40 45

Pro Leu Val Phe His Thr Asn Arg Gly Pro Ile Lys Phe Asn Val Trp

50 55 60

Asp Thr Ala Gly Gln Glu Lys Phe Gly Gly Leu Arg Asp Gly Tyr Tyr

65 70 75 80

Ile Gln Ala Gln Cys Ala Ile Ile Met Phe Asp Val Thr Ser Arg Val

85 90 95

Thr Tyr Lys Asn Val Pro Asn Trp His Arg Asp Leu Val Arg Val Cys

100 105 110

Glu Asn Ile Pro Ile Val Leu Cys Gly Asn Lys Val Asp Ile Lys Asp

115 120 125

Arg Lys Val Lys Ala Lys Ser Ile Val Phe His Arg Lys Lys Asn Leu

130 135 140

Gln Tyr Tyr Asp Ile Ser Ala Lys Ser Asn Tyr Asn Phe Glu Lys Pro

145 150 155 160

Phe Leu Trp Leu Ala Arg Lys Leu Ile Gly Asp Pro Asn Leu Glu Phe

165 170 175

Val Ala Met Pro Ala Leu Ala Pro Pro Glu Val Val Met Asp Pro Ala

180 185 190

Leu Ala Ala Gln Tyr Glu His Asp Leu Glu Val Ala Gln Thr Thr Ala

195 200 205

Leu Pro Asp Glu Asp Asp Asp Leu

210 215

<210>28

<211>463

<212>PRT

<213> Human (Homo sapiens)

<220>

<221> Nuclear heterogeneous ribonucleic acid protein K

<222>(1)..(463)

<223> December 9, 2002 Registration number: Q07244

<400>28

Met Glu Thr Glu Gln Pro Glu Glu Thr Phe Pro Asn Thr Glu Thr Asn

1 5 10 15

Gly Glu Phe Gly Lys Arg Pro Ala Glu Asp Met Glu Glu Glu Gln Ala

20 25 30

Phe Lys Arg Ser Arg Asn Thr Asp Glu Met Val Glu Leu Arg Ile Leu

35 40 45

Leu Gln Ser Lys Asn Ala Gly Ala Val Ile Gly Lys Gly Gly Lys Asn

50 55 60

Ile Lys Ala Leu Arg Thr Asp Tyr Asn Ala Ser Val Ser Val Pro Asp

65 70 75 80

Ser Ser Gly Pro Glu Arg Ile Leu Ser Ile Ser Ala Asp Ile Glu Thr

85 90 95

Ile Gly Glu Ile Leu Lys Lys Ile Ile Pro Thr Leu Glu Glu Gly Leu

100 105 110

Gln Leu Pro Ser Pro Thr Ala Thr Ser Gln Leu Pro Leu Glu Ser Asp

115 120 125

Ala Val Glu Cys Leu Asn Tyr Gln His Tyr Lys Gly Ser Asp Phe Asp

130 135 140

Cys Glu Leu Arg Leu Leu Ile His Gln Ser Leu Ala Gly Gly Ile Ile

145 150 155 160

Gly Val Lys Gly Ala Lys Ile Lys Glu Leu Arg Glu Asn Thr Gln Thr

165 170 175

Thr Ile Lys Leu Phe Gln Glu Cys Cys Pro His Ser Thr Asp Arg Val

180 185 190

Val Leu Ile Gly Gly Lys Pro Asp Arg Val Val Glu Cys Ile Lys Ile

195 200 205

Ile Leu Asp Leu Ile Ser Glu Ser Pro Ile Lys Gly Arg Ala Gln Pro

210 215 220

Tyr Asp Pro Asn Phe Tyr Asp Glu Thr Tyr Asp Tyr Gly Gly Phe Thr

225 230 235 240

Met Met Phe Asp Asp Arg Arg Gly Arg Pro Val Gly Phe Pro Met Arg

245 250 255

Gly Arg Gly Gly Phe Asp Arg Met Pro Pro Gly Arg Gly Gly Arg Pro

260 265 270

Met Pro Pro Ser Arg Arg Asp Tyr Asp Asp Met Ser Pro Arg Arg Gly

275 280 285

Pro Pro Pro Pro Pro Pro Gly Arg Gly Gly Arg Gly Gly Ser Arg Ala

290 295 300

Arg Asn Leu Pro Leu Pro Pro Pro Pro Pro Pro Pro Arg Gly Gly Asp Leu

305 310 315 320

Met Ala Tyr Asp Arg Arg Gly Arg Pro Gly Asp Arg Tyr Asp Gly Met

325 330 335

Val Gly Phe Ser Ala Asp Glu Thr Trp Asp Ser Ala Ile Asp Thr Trp

340 345 350

Ser Pro Ser Glu Trp Gln Met Ala Tyr Glu Pro Gln Gly Gly Ser Gly

355 360 365

Tyr Asp Tyr Ser Tyr Ala Gly Gly Arg Gly Ser Tyr Gly Asp Leu Gly

370 375 380

Gly Pro Ile Ile Thr Thr Gln Val Thr Ile Pro Lys Asp Leu Ala Gly

385 390 395 400

Ser Ile Ile Gly Lys Gly Gly Gln Arg Ile Lys Gln Ile Arg His Glu

405 410 415

Ser Gly Ala Ser Ile Lys Ile Asp Glu Pro Leu Glu Gly Ser Glu Asp

420 425 430

Arg Ile Ile Thr Ile Thr Gly Thr Gln Asp Gln Ile Gln Asn Ala Gln

435 440 445

Tyr Leu Leu Gln Asn Ser Val Lys Gln Tyr Ser Gly Lys Phe Phe

450 455 460

<210>29

<211>172

<212>PRT

<213> Human (Homo sapiens)

<220>

<221> Translationally regulated tumor protein (TCTP)

<222>(1)..(172)

<223> December 9, 2002 Registration number: P13693

<400>29

Met Ile Ile Tyr Arg Asp Leu Ile Ser His Asp Glu Met Phe Ser Asp

1 5 10 15

Ile Tyr Lys Ile Arg Glu Ile Ala Asp Gly Leu Cys Leu Glu Val Glu

20 25 30

Gly Lys Met Val Ser Arg Thr Glu Gly Asn Ile Asp Asp Ser Leu Ile

35 40 45

Gly Gly Asn Ala Ser Ala Glu Gly Pro Glu Gly Glu Gly Thr Glu Ser

50 55 60

Thr Val Ile Thr Gly Val Asp Ile Val Met Asn His His Leu Gln Glu

65 70 75 80

Thr Ser Phe Thr Lys Glu Ala Tyr Lys Lys Tyr Ile Lys Asp Tyr Met

85 90 95

Lys Ser Ile Lys Gly Lys Leu Glu Glu Gln Arg Pro Glu Arg Val Lys

100 105 110

Pro Phe Met Thr Gly Ala Ala Glu Gln Ile Lys His Ile Leu Ala Asn

115 120 125

Phe Lys Asn Tyr Gln Phe Phe Ile Gly Glu Asn Met Asn Pro Asp Gly

130 135 140

Met Val Ala Leu Leu Asp Tyr Arg Glu Asp Gly Val Thr Pro Tyr Met

145 150 155 160

Ile Phe Phe Lys Asp Gly Leu Glu Met Glu Lys Cys

165 170

<210>30

<211>284

<212>PRT

<213> Human (Homo sapiens)

<220>

<221> tropomyosin 1-alpha chain

<222>(1)..(284)

<223> December 6, 2002 Registration number: P09493

<400>30

Met Asp Ala Ile Lys Lys Lys Met Gln Met Leu Lys Leu Asp Lys Glu

1 5 10 15

Asn Ala Leu Asp Arg Ala Glu Gln Ala Glu Ala Asp Lys Lys Ala Ala

20 25 30

Glu Asp Arg Ser Lys Gln Leu Glu Asp Glu Leu Val Ser Leu Gln Lys

35 40 45

Lys Leu Lys Gly Thr Glu Asp Glu Leu Asp Lys Tyr Ser Glu Ala Leu

50 55 60

Lys Asp Ala Gln Glu Lys Leu Glu Leu Ala Glu Lys Lys Ala Thr Asp

65 70 75 80

Ala Glu Ala Asp Val Ala Ser Leu Asn Arg Arg Ile Gln Leu Val Glu

85 90 95

Glu Glu Leu Asp Arg Ala Gln Glu Arg Leu Ala Thr Ala Leu Gln Lys

100 105 110

Leu Glu Glu Ala Glu Lys Ala Ala Asp Glu Ser Glu Arg Gly Met Lys

115 120 125

Val Ile Glu Ser Arg Ala Gln Lys Asp Glu Glu Lys Met Glu Ile Gln

130 135 140

Glu Ile Gln Leu Lys Glu Ala Lys His Ile Ala Glu Asp Ala Asp Arg

145 150 155 160

Lys Tyr Glu Glu Val Ala Arg Lys Leu Val Ile Ile Glu Ser Asp Leu

165 170 175

Glu Arg Ala Glu Glu Arg Ala Glu Leu Ser Glu Gly Lys Cys Ala Glu

180 185 190

Leu Glu Glu Glu Leu Lys Thr Val Thr Asn Asn Asn Leu Lys Ser Leu Glu

195 200 205

Ala Gln Ala Glu Lys Tyr Ser Gln Lys Glu Asp Arg Tyr Glu Glu Glu Glu

210 215 220

Ile Lys Val Leu Ser Asp Lys Leu Lys Glu Ala Glu Thr Arg Ala Glu

225 230 235 240

Phe Ala Glu Arg Ser Val Thr Lys Leu Glu Lys Ser Ile Asp Asp Leu

245 250 255

Glu Asp Glu Leu Tyr Ala Gln Lys Leu Lys Tyr Lys Ala Ile Ser Glu

260 265 270

Glu Leu Asp His Ala Leu Asn Asp Met Thr Ser Ile

275 280

<210>31

<211>482

<212>PRT

<213> Human (Homo sapiens)

<220>

<221> Thymidine phosphorylase precursor

<222>(1)..(482)

<223> December 9, 2002 Registration number: P19971

<400>31

Met Ala Ala Leu Met Thr Pro Gly Thr Gly Ala Pro Pro Ala Pro Gly

1 5 10 15

Asp Phe Ser Gly Glu Gly Ser Gln Gly Leu Pro Asp Pro Ser Pro Glu

20 25 30

Pro Lys Gln Leu Pro Glu Leu Ile Arg Met Lys Arg Asp Gly Gly Arg

35 40 45

Leu Ser Glu Ala Asp Ile Arg Gly Phe Val Ala Ala Val Val Asn Gly

50 55 60

Ser Ala Gln Gly Ala Gln Ile Gly Ala Met Leu Met Ala Ile Arg Leu

65 70 75 80

Arg Gly Met Asp Leu Glu Glu Thr Ser Val Leu Thr Gln Ala Leu Ala

85 90 95

Gln Ser Gly Gln Gln Leu Glu Trp Pro Glu Ala Trp Arg Gln Gln Leu

100 105 110

Val Asp Lys His Ser Thr Gly Gly Val Gly Asp Lys Val Ser Leu Val

115 120 125

Leu Ala Pro Ala Leu Ala Ala Cys Gly Cys Lys Val Pro Met Ile Ser

130 135 140

Gly Arg Gly Leu Gly His Thr Gly Gly Thr Leu Asp Lys Leu Glu Ser

145 150 155 160

Ile Pro Gly Phe Asn Val Ile Gln Ser Pro Glu Gln Met Gln Val Leu

165 170 175

Leu Asp Gln Ala Gly Cys Cys Ile Val Gly Gln Ser Glu Gln Leu Val

180 185 190

Pro Ala Asp Gly Ile Leu Tyr Ala Ala Arg Asp Val Thr Ala Thr Val

195 200 205

Asp Ser Leu Pro Leu Ile Thr Ala Ser Ile Leu Ser Lys Lys Leu Val

210 215 220

Glu Gly Leu Ser Ala Ala Leu Val Val Asp Val Lys Phe Gly Gly Ala Ala

225 230 235 240

Val Phe Pro Asn Gln Glu Gln Ala Arg Glu Leu Ala Lys Thr Leu Val

245 250 255

Gly Val Gly Ala Ser Leu Gly Leu Arg Val Ala Ala Ala Leu Thr Ala

260 265 270

Met Asp Lys Pro Leu Gly Arg Cys Val Gly His Ala Leu Glu Val Glu

275 280 285

Glu Ala Leu Leu Cys Met Asp Gly Ala Gly Pro Pro Asp Leu Arg Asp

290 295 300

Leu Val Thr Thr Leu Gly Gly Ala Leu Leu Trp Leu Ser Gly His Ala

305 310 315 320

Gly Thr Gln Ala Gln Gly Ala Ala Arg Val Ala Ala Ala Leu Asp Asp

325 330 335

Gly Ser Ala Leu Gly Arg Phe Glu Arg Met Leu Ala Ala Gln Gly Val

340 345 350

Asp Pro Gly Leu Ala Arg Ala Leu Cys Ser Gly Ser Pro Ala Glu Arg

355 360 365

Arg Gln Leu Leu Pro Arg Ala Arg Glu Gln Glu Glu Leu Leu Ala Pro

370 375 380

Ala Asp Gly Thr Val Glu Leu Val Arg Ala Leu Pro Leu Ala Leu Val

385 390 395 400

Leu His Glu Leu Gly Ala Gly Arg Ser Arg Ala Gly Glu Pro Leu Arg

405 410 415

Leu Gly Val Gly Ala Glu Leu Leu Val Asp Val Gly Gln Arg Leu Arg

420 425 430

Arg Gly Thr Pro Trp Leu Arg Val His Arg Asp Gly Pro Ala Leu Ser

435 440 445

Gly Pro Gln Ser Arg Ala Leu Gln Glu Ala Leu Val Leu Ser Asp Arg

450 455 460

Ala Pro Phe Ala Ala Pro Leu Pro Phe Ala Glu Leu Val Leu Pro Pro

465 470 475 480

Gln Gln

<210>32

<211>488

<212>PRT

<213> Human (Homo sapiens)

<220>

<221> Cytosolic Aminase

<222>(1)..(488)

<223> December 9, 2002 Registration number: P28838

<400>32

Met Thr Lys Gly Leu Val Leu Gly Ile Tyr Ser Lys Glu Lys Glu Asp

1 5 10 15

Asp Val Pro Gln Phe Thr Ser Ala Gly Glu Asn Phe Asp Lys Leu Leu

20 25 30

Ala Gly Lys Leu Arg Glu Thr Leu Asn Ile Ser Gly Pro Pro Leu Lys

35 40 45

Ala Gly Lys Thr Arg Thr Phe Tyr Gly Leu His Gln Asp Phe Pro Ser

50 55 60

Val Val Leu Val Gly Leu Gly Lys Lys Ala Ala Gly Ile Asp Glu Gln

65 70 75 80

Glu Asn Trp His Glu Gly Lys Glu Asn Ile Arg Ala Ala Val Ala Ala

85 90 95

Gly Cys Arg Gln Ile Gln Asp Leu Glu Leu Ser Ser Val Glu Val Asp

100 105 110

Pro Cys Gly Asp Ala Gln Ala Ala Ala Glu Gly Ala Val Leu Gly Leu

115 120 125

Tyr Glu Tyr Asp Asp Leu Lys Gln Lys Lys Lys Met Ala Val Ser Ala

130 135 140

Lys Leu Tyr Gly Ser Gly Asp Gln Glu Ala Trp Gln Lys Gly Val Leu

145 150 155 160

Phe Ala Ser Gly Gln Asn Leu Ala Arg Gln Leu Met Glu Thr Pro Ala

165 170 175

Asn Glu Met Thr Pro Thr Arg Phe Ala Glu Ile Ile Glu Lys Asn Leu

180 185 190

Lys Ser Ala Ser Ser Lys Thr Glu Val His Ile Arg Pro Lys Ser Trp

195 200 205

Ile Glu Glu Gln Ala Met Gly Ser Phe Leu Ser Val Ala Lys Gly Ser

210 215 220

Asp Glu Pro Pro Val Phe Leu Glu Ile His Tyr Lys Gly Ser Pro Asn

225 230 235 240

Ala Asn Glu Pro Pro Leu Val Phe Val Gly Lys Gly Ile Thr Phe Asp

245 250 255

Ser Gly Gly Ile Ser Ile Lys Ala Ser Ala Asn Met Asp Leu Met Arg

260 265 270

Ala Asp Met Gly Gly Ala Ala Thr Ile Cys Ser Ala Ile Val Ser Ala

275 280 285

Ala Lys Leu Asn Leu Pro Ile Asn Ile Ile Gly Leu Ala Pro Leu Cys

290 295 300

Glu Asn Met Pro Ser Gly Lys Ala Asn Lys Pro Gly Asp Val Val Arg

305 310 315 320

Ala Lys Asn Gly Lys Thr Ile Gln Val Asp Asn Thr Asp Ala Glu Gly

325 330 335

Arg Leu Ile Leu Ala Asp Ala Leu Cys Tyr Ala His Thr Phe Asn Pro

340 345 350

Lys Val Ile Leu Asn Ala Ala Thr Leu Thr Gly Ala Met Asp Val Ala

355 360 365

Leu Gly Ser Gly Ala Thr Gly Val Phe Thr Asn Ser Ser Trp Leu Trp

370 375 380

Asn Lys Leu Phe Glu Ala Ser Ile Glu Thr Gly Asp Arg Val Trp Arg

385 390 395 400

Met Pro Leu Phe Glu His Tyr Thr Arg Gln Val Val Asp Cys Gln Leu

405 410 415

Ala Asp Val Asn Asn Ile Gly Lys Tyr Arg Ser Ala Gly Ala Cys Thr

420 425 430

Ala Ala Ala Phe Leu Lys Glu Phe Val Thr His Pro Lys Trp Ala His

435 440 445

Leu Asp Ile Ala Gly Val Met Thr Asn Lys Asp Glu Val Pro Tyr Leu

450 455 460

Arg Lys Gly Met Thr Gly Arg Pro Thr Arg Thr Leu Ile Glu Phe Leu

465 470 475 480

Leu Arg Phe Ser Gln Asp Asn Ala

485

<210>33

<211>400

<212>PRT

<213> Human (Homo sapiens)

<220>

<221> Type I cytoskeleton 19 keratin

<222>(1)..(400)

<223> December 9, 2002 Registration number: P08727

<400>33

Met Thr Ser Tyr Ser Tyr Arg Gln Ser Ser Ala Thr Ser Ser Phe Gly

1 5 10 15

Gly Leu Gly Gly Gly Ser Val Arg Phe Gly Pro Gly Val Ala Phe Arg

20 25 30

Ala Pro Ser Ile His Gly Gly Ser Gly Gly Arg Gly Val Ser Val Ser

35 40 45

Ser Ala Arg Phe Val Ser Ser Ser Ser Ser Ser Ser Gly Gly Tyr Gly Gly Gly

50 55 60

Tyr Gly Gly Val Leu Thr Ala Ser Asp Gly Leu Leu Ala Gly Asn Glu

65 70 75 80

Lys Leu Thr Met Gln Asn Leu Asn Asp Arg Leu Ala Ser Tyr Leu Asp

85 90 95

Lys Val Arg Ala Leu Glu Ala Ala Asn Gly Glu Leu Glu Val Lys Ile

100 105 110

Arg Asp Trp Tyr Gln Lys Gln Gly Pro Gly Pro Ser Arg Asp Tyr Ser

115 120 125

His Tyr Tyr Thr Thr Ile Gln Asp Leu Arg Asp Lys Ile Leu Gly Ala

130 135 140

Thr Ile Glu Asn Ser Arg Ile Val Leu Gln Ile Asp Asn Ala Arg Leu

145 150 155 160

Ala Ala Asp Asp Phe Arg Thr Lys Phe Glu Thr Glu Gln Ala Leu Arg

165 170 175

Met Ser Val Glu Ala Asp Ile Asn Gly Leu Arg Arg Val Leu Asp Glu

180 185 190

Leu Thr Leu Ala Arg Thr Asp Leu Glu Met Gln Ile Glu Gly Leu Lys

195 200 205

Glu Glu Leu Ala Tyr Leu Lys Lys Asn His Glu Glu Glu Ile Ser Thr

210 215 220

Leu Arg Gly Gln Val Gly Gly Gln Val Ser Val Glu Val Asp Ser Ala

225 230 235 240

Pro Gly Thr Asp Leu Ala Lys Ile Leu Ser Asp Met Arg Ser Gln Tyr

245 250 255

Glu Val Met Ala Glu Gln Asn Arg Lys Asp Ala Glu Ala Trp Phe Thr

260 265 270

Ser Arg Thr Glu Glu Leu Asn Arg Glu Val Ala Gly His Thr Glu Gln

275 280 285

Leu Gln Met Ser Arg Ser Glu Val Thr Asp Leu Arg Arg Thr Leu Gln

290 295 300

Gly Leu Glu Ile Glu Leu Gln Ser Gln Leu Ser Met Lys Ala Ala Leu

305 310 315 320

Glu Asp Thr Leu Ala Glu Thr Glu Ala Arg Phe Gly Ala Gln Leu Ala

325 330 335

His Ile Gln Ala Leu Ile Ser Gly Ile Glu Ala Gln Leu Ala Asp Val

340 345 350

Arg Ala Asp Ser Glu Arg Gln Asn Gln Glu Tyr Gln Arg Leu Met Asp

355 360 365

Ile Lys Ser Arg Leu Glu Gln Glu Ile Ala Thr Tyr Arg Ser Leu Leu

370 375 380

Glu Gly Gln Glu Asp His Tyr Asn Asn Leu Ser Ala Ser Lys Val Leu

385 390 395 400

<210>34

<211>325

<212>PRT

<213> Human (Homo sapiens)

<220>

<221> Alcohol dehydrogenase [NADP+]

<222>(1)..(325)

<223> December 9, 2002 Registration number: P14550

<400>34

Met Ala Ala Ser Cys Val Leu Leu His Thr Gly Gln Lys Met Pro Leu

1 5 10 15

Ile Gly Leu Gly Thr Trp Lys Ser Glu Pro Gly Gln Val Lys Ala Ala

20 25 30

Val Lys Tyr Ala Leu Ser Val Gly Tyr Arg His Ile Asp Cys Ala Ala

35 40 45

Ile Tyr Gly Asn Glu Pro Glu Ile Gly Glu Ala Leu Lys Glu Asp Val

50 55 60

Gly Pro Gly Lys Ala Val Pro Arg Glu Glu Leu Phe Val Thr Ser Lys

65 70 75 80

Leu Trp Asn Thr Lys His His Pro Glu Asp Val Glu Pro Ala Leu Arg

85 90 95

Lys Thr Leu Ala Asp Leu Gln Leu Glu Tyr Leu Asp Leu Tyr Leu Met

100 105 110

His Trp Pro Tyr Ala Phe Glu Arg Gly Asp Asn Pro Phe Pro Lys Asn

115 120 125

Ala Asp Gly Thr Ile Cys Tyr Asp Ser Thr His Tyr Lys Glu Thr Trp

130 135 140

Lys Ala Leu Glu Ala Leu Val Ala Lys Gly Leu Val Gln Ala Leu Gly

145 150 155 160

Leu Ser Asn Phe Asn Ser Arg Gln Ile Asp Asp Ile Leu Ser Val Ala

165 170 175

Ser Val Arg Pro Ala Val Leu Gln Val Glu Cys His Pro Tyr Leu Ala

180 185 190

Gln Asn Glu Leu Ile Ala His Cys Gln Ala Arg Gly Leu Glu Val Thr

195 200 205

Ala Tyr Ser Pro Leu Gly Ser Ser Asp Arg Ala Trp Arg Asp Pro Asp

210 215 220

Glu Pro Val Leu Leu Glu Glu Pro Val Val Leu Ala Leu Ala Glu Lys

225 230 235 240

Tyr Gly Arg Ser Pro Ala Gln Ile Leu Leu Arg Trp Gln Val Gln Arg

245 250 255

Lys Val Ile Cys Ile Pro Lys Ser Ile Thr Pro Ser Arg Ile Leu Gln

260 265 270

Asn Ile Lys Val Phe Asp Phe Thr Phe Ser Pro Glu Glu Met Lys Gln

275 280 285

Leu Asn Ala Leu Asn Lys Asn Trp Arg Tyr Ile Val Pro Met Leu Thr

290 295 300

Val Asp Gly Lys Arg Val Pro Arg Asp Ala Gly His Pro Leu Tyr Pro

305 310 315 320

Phe Asn Asp Pro Tyr

325

<210>35

<211>270

<212>PRT

<213> Human (Homo sapiens)

<220>

<221> Elastase IIIA precursor

<222>(1)..(270)

<223> December 9, 2002 Registration number: P09093

<400>35

Met Met Leu Arg Leu Leu Ser Ser Leu Leu Leu Val Ala Val Ala Ser

1 5 10 15

Gly Tyr Gly Pro Pro Ser Ser His Ser Ser Ser Ser Arg Val Val His Gly

20 25 30

Glu Asp Ala Val Pro Tyr Ser Trp Pro Trp Gln Val Ser Leu Gln Tyr

35 40 45

Glu Lys Ser Gly Ser Phe Tyr His Thr Cys Gly Gly Ser Leu Ile Ala

50 55 60

Pro Asp Trp Val Val Thr Ala Gly His Cys Ile Ser Arg Asp Leu Thr

65 70 75 80

Tyr Gln Val Val Leu Gly Glu Tyr Asn Leu Ala Val Lys Glu Gly Pro

85 90 95

Glu Gln Val Ile Pro Ile Asn Ser Glu Glu Leu Phe Val His Pro Leu

100 105 110

Trp Asn Arg Ser Cys Val Ala Cys Gly Asn Asp Ile Ala Leu Ile Lys

115 120 125

Leu Ser Arg Ser Ala Gln Leu Gly Asp Ala Val Gln Leu Ala Ser Leu

130 135 140

Pro Pro Ala Gly Asp Ile Leu Pro Asn Lys Thr Pro Cys Tyr Ile Thr

145 150 155 160

Gly Trp Gly Arg Leu Tyr Thr Asn Gly Pro Leu Pro Asp Lys Leu Gln

165 170 175

Gln Ala Arg Leu Pro Val Val Asp Tyr Lys His Cys Ser Arg Trp Asn

180 185 190

Trp Trp Gly Ser Thr Val Lys Lys Thr Met Val Cys Ala Gly Gly Tyr

195 200 205

Ile Arg Ser Gly Cys Asn Gly Asp Ser Gly Gly Pro Leu Asn Cys Pro

210 215 220

Thr Glu Asp Gly Gly Trp Gln Val His Gly Val Thr Ser Phe Val Ser

225 230 235 240

Gly Phe Gly Cys Asn Phe Ile Trp Lys Pro Thr Val Phe Thr Arg Val

245 250 255

Ser Ala Phe Ile Asp Trp Ile Glu Glu Thr Ile Ala Ser His

260 265 270

<210>36

<211>509

<212>PRT

<213> Human (Homo sapiens)

<220>

<221> Mitochondrial dihydrolipoamide dehydrogenase precursor

<222>(1)..(509)

<223> December 9, 2002 Registration number: P09622

<400>36

Met Gln Ser Trp Ser Arg Val Tyr Cys Ser Leu Ala Lys Arg Gly His

1 5 10 15

Phe Asn Arg Ile Ser His Gly Leu Gln Gly Leu Ser Ala Val Pro Leu

20 25 30

Arg Thr Tyr Ala Asp Gln Pro Ile Asp Ala Asp Val Thr Val Ile Gly

35 40 45

Ser Gly Pro Gly Gly Tyr Val Ala Ala Ile Lys Ala Ala Gln Leu Gly

50 55 60

Phe Lys Thr Val Cys Ile Glu Lys Asn Glu Thr Leu Gly Gly Thr Cys

65 70 75 80

Leu Asn Val Gly Cys Ile Pro Ser Lys Ala Leu Leu Asn Asn Ser His

85 90 95

Tyr Tyr His Met Ala His Gly Thr Asp Phe Ala Ser Arg Gly Ile Glu

100 105 110

Met Ser Glu Val Arg Leu Asn Leu Asp Lys Met Met Glu Gln Lys Ser

115 120 125

Thr Ala Val Lys Ala Leu Thr Gly Gly Ile Ala His Leu Phe Lys Gln

130 135 140

Asn Lys Val Val His Val Asn Gly Tyr Gly Lys Ile Thr Gly Lys Asn

145 150 155 160

Gln Val Thr Ala Thr Lys Ala Asp Gly Gly Thr Gln Val Ile Asp Thr

165 170 175

Lys Asn Ile Leu Ile Ala Thr Gly Ser Glu Val Thr Pro Phe Pro Gly

180 185 190

Ile Thr Ile Asp Glu Asp Thr Ile Val Ser Ser Thr Gly Ala Leu Ser

195 200 205

Leu Lys Lys Val Pro Glu Lys Met Val Val Ile Gly Ala Gly Val Ile

210 215 220

Gly Val Glu Leu Gly Ser Val Trp Gln Arg Leu Gly Ala Asp Val Thr

225 230 235 240

Ala Val Glu Phe Leu Gly His Val Gly Gly Val Gly Ile Asp Met Glu

245 250 255

Ile Ser Lys Asn Phe Gln Arg Ile Leu Gln Lys Gln Gly Phe Lys Phe

260 265 270

Lys Leu Asn Thr Lys Val Thr Gly Ala Thr Lys Lys Ser Asp Gly Lys

275 280 285

Ile Asp Val Ser Ile Glu Ala Ala Ser Gly Gly Lys Ala Glu Val Ile

290 295 300

Thr Cys Asp Val Leu Leu Val Cys Ile Gly Arg Arg Pro Phe Thr Lys

305 310 315 320

Asn Leu Gly Leu Glu Glu Leu Gly Ile Glu Leu Asp Pro Arg Gly Arg

325 330 335

Ile Pro Val Asn Thr Arg Phe Gln Thr Lys Ile Pro Asn Ile Tyr Ala

340 345 350

Ile Gly Asp Val Val Ala Gly Pro Met Leu Ala His Lys Ala Glu Asp

355 360 365

Glu Gly Ile Ile Cys Val Glu Gly Met Ala Gly Gly Ala Val His Ile

370 375 380

Asp Tyr Asn Cys Val Pro Ser Val Ile Tyr Thr His Pro Glu Val Ala

385 390 395 400

Trp Val Gly Lys Ser Glu Glu Gln Leu Lys Glu Glu Gly Ile Glu Tyr

405 410 415

Lys Val Gly Lys Phe Pro Phe Ala Ala Asn Ser Arg Ala Lys Thr Asn

420 425 430

Ala Asp Thr Asp Gly Met Val Lys Ile Leu Gly Gln Lys Ser Thr Asp

435 440 445

Arg Val Leu Gly Ala His Ile Leu Gly Pro Gly Ala Gly Glu Met Val

450 455 460

Asn Glu Ala Ala Leu Ala Leu Glu Tyr Gly Ala Ser Cys Glu Asp Ile

465 470 475 480

Ala Arg Val Cys His Ala His Pro Thr Leu Ser Glu Ala Phe Arg Glu

485 490 495

Ala Asn Leu Ala Ala Ser Phe Gly Lys Ser Ile Asn Phe

500 505

<210>37

<211>290

<212>PRT

<213> Human (Homo sapiens)

<220>

<221> Mitochondrial enoyl-CoA hydratase precursor

<222>(1)..(290)

<223> December 9, 2002 Registration number: P30084

<400>37

Met Ala Ala Leu Arg Val Leu Leu Ser Cys Ala Arg Gly Pro Leu Arg

1 5 10 15

Pro Pro Val Arg Cys Pro Ala Trp Arg Pro Phe Ala Ser Gly Ala Asn

20 25 30

Phe Glu Tyr Ile Ile Ala Glu Lys Arg Gly Lys Asn Asn Thr Val Gly

35 40 45

Leu Ile Gln Leu Asn Arg Pro Lys Ala Leu Asn Ala Leu Cys Asp Gly

50 55 60

Leu Ile Asp Glu Leu Asn Gln Ala Leu Lys Ile Phe Glu Glu Asp Pro

65 70 75 80

Ala Val Gly Ala Ile Val Leu Thr Gly Gly Asp Lys Ala Phe Ala Ala

85 90 95

Gly Ala Asp Ile Lys Glu Met Gln Asn Leu Ser Phe Gln Asp Cys Tyr

100 105 110

Ser Ser Lys Phe Leu Lys His Trp Asp His Leu Thr Gln Val Lys Lys

115 120 125

Pro Val Ile Ala Ala Val Asn Gly Tyr Ala Phe Gly Gly Gly Cys Glu

130 135 140

Leu Ala Met Met Cys Asp Ile Ile Tyr Ala Gly Glu Lys Ala Gln Phe

145 150 155 160

Ala Gln Pro Glu Ile Leu Ile Gly Thr Ile Pro Gly Ala Gly Gly Thr

165 170 175

Gln Arg Leu Thr Arg Ala Val Gly Lys Ser Leu Ala Met Glu Met Val

180 185 190

Leu Thr Gly Asp Arg Ile Ser Ala Gln Asp Ala Lys Gln Ala Gly Leu

195 200 205

Val Ser Lys Ile Cys Pro Val Glu Thr Leu Val Glu Glu Ala Ile Gln

210 215 220

Cys Ala Glu Lys Ile Ala Ser Asn Ser Lys Ile Val Val Ala Met Ala

225 230 235 240

Lys Glu Ser Val Asn Ala Ala Phe Glu Met Thr Leu Thr Glu Gly Ser

245 250 255

Lys Leu Glu Lys Lys Leu Phe Tyr Ser Thr Phe Ala Thr Asp Asp Arg

260 265 270

Lys Glu Gly Met Thr Ala Phe Val Glu Lys Arg Lys Ala Asn Phe Lys

275 280 285

Asp Gln

290

<210>38

<211>160

<212>PRT

<213> Human (Homo sapiens)

<220>

<221> heat shock-like 20kDa protein p20

<222>(1)..(160)

<223> December 9, 2002 Registration number: 014558

<400>38

Met Glu Ile Pro Val Pro Val Gln Pro Ser Trp Leu Arg Arg Ala Ser

1 5 10 15

Ala Pro Leu Pro Gly Leu Ser Ala Pro Gly Arg Leu Phe Asp Gln Arg

20 25 30

Phe Gly Glu Gly Leu Leu Glu Ala Glu Leu Ala Ala Leu Cys Pro Thr

35 40 45

Thr Leu Ala Pro Tyr Tyr Leu Arg Ala Pro Ser Val Ala Leu Pro Val

50 55 60

Ala Gln Val Pro Thr Asp Pro Gly His Phe Ser Val Leu Leu Asp Val

65 70 75 80

Lys His Phe Ser Pro Glu Glu Ile Ala Val Lys Val Val Gly Glu His

85 90 95

Val Glu Val His Ala Arg His Glu Glu Arg Pro Asp Glu His Gly Phe

100 105 110

Val Ala Arg Glu Phe His Arg Arg Tyr Arg Leu Pro Pro Gly Val Asp

115 120 125

Pro Ala Ala Val Thr Ser Ala Leu Ser Pro Glu Gly Val Leu Ser Ile

130 135 140

Gln Ala Ala Pro Ala Ser Ala Gln Ala Pro Pro Pro Ala Ala Ala Lys

145 150 155 160

<210>39

<211>151

<212>PRT

<213> Human (Homo sapiens)

<220>

<221> non-muscle isoform basic myosin light chain

<222>(1)..(151)

<223> December 9, 2002 Registration number: P16475

<400>39

Met Cys Asp Phe Thr Glu Asp Gln Thr Ala Glu Phe Lys Glu Ala Phe

1 5 10 15

Gln Leu Phe Asp Arg Thr Gly Asp Gly Lys Ile Leu Tyr Ser Gln Cys

20 25 30

Gly Asp Val Met Arg Ala Leu Gly Gln Asn Pro Thr Asn Ala Glu Val

35 40 45

Leu Lys Val Leu Gly Asn Pro Lys Ser Asp Glu Met Asn Val Lys Val

50 55 60

Leu Asp Phe Glu His Phe Leu Pro Met Leu Gln Thr Val Ala Lys Asn

65 70 75 80

Lys Asp Gln Gly Thr Tyr Glu Asp Tyr Val Glu Gly Leu Arg Val Phe

85 90 95

Asp Lys Glu Gly Asn Gly Thr Val Met Gly Ala Glu Ile Arg His Val

100 105 110

Leu Val Thr Leu Gly Glu Lys Met Thr Glu Glu Glu Val Glu Met Leu

115 120 125

Val Ala Gly His Glu Asp Ser Asn Gly Cys Ile Asn Tyr Glu Ala Phe

130 135 140

Val Arg His Ile Leu Ser Gly

145 150

<210>40

<211>592

<212>PRT

<213> Human (Homo sapiens)

<220>

<221> Calnexin precursor

<222>(1)..(592)

<223> December 9, 2002 Registration number: P27824

<400>40

Met Glu Gly Lys Trp Leu Leu Cys Met Leu Leu Val Leu Gly Thr Ala

1 5 10 15

Ile Val Glu Ala His Asp Gly His Asp Asp Asp Val Ile Asp Ile Glu

20 25 30

Asp Asp Leu Asp Asp Val Ile Glu Glu Val Glu Asp Ser Lys Pro Asp

35 40 45

Thr Thr Ala Pro Pro Ser Ser Pro Lys Val Thr Tyr Lys Ala Pro Val

50 55 60

Pro Thr Gly Glu Val Tyr Phe Ala Asp Ser Phe Asp Arg Gly Thr Leu

65 70 75 80

Ser Gly Trp Ile Leu Ser Lys Ala Lys Lys Asp Asp Thr Asp Asp Glu

85 90 95

Ile Ala Lys Tyr Asp Gly Lys Trp Glu Val Glu Glu Met Lys Glu Ser

100 105 110

Lys Leu Pro Gly Asp Lys Gly Leu Val Leu Met Ser Arg Ala Lys His

115 120 125

His Ala Ile Ser Ala Lys Leu Asn Lys Pro Phe Leu Phe Asp Thr Lys

130 135 140

Pro Leu Ile Val Gln Tyr Glu Val Asn Phe Gln Asn Gly Ile Glu Cys

145 150 155 160

Gly Gly Ala Tyr Val Lys Leu Leu Ser Lys Thr Pro Glu Leu Asn Leu

165 170 175

Asp Gln Phe His Asp Lys Thr Pro Tyr Thr Ile Met Phe Gly Pro Asp

180 185 190

Lys Cys Gly Glu Asp Tyr Lys Leu His Phe Ile Phe Arg His Lys Asn

195 200 205

Pro Lys Thr Gly Ile Tyr Glu Glu Lys His Ala Lys Arg Pro Asp Ala

210 215 220

Asp Leu Lys Thr Tyr Phe Thr Asp Lys Lys Thr His Leu Tyr Thr Leu

225 230 235 240

Ile Leu Asn Pro Asp Asn Ser Phe Glu Ile Leu Val Asp Gln Ser Val

245 250 255

Val Asn Ser Gly Asn Leu Leu Asn Asp Met Thr Pro Pro Val Asn Pro

260 265 270

Ser Arg Glu Ile Glu Asp Pro Glu Asp Arg Lys Pro Glu Asp Trp Asp

275 280 285

Glu Arg Pro Lys Ile Pro Asp Pro Glu Ala Val Lys Pro Asp Asp Trp

290 295 300

Asp Glu Asp Ala Pro Ala Lys Ile Pro Asp Glu Glu Ala Thr Lys Pro

305 310 315 320

Glu Gly Trp Leu Asp Asp Glu Pro Glu Tyr Val Pro Asp Pro Asp Ala

325 330 335

Glu Lys Pro Glu Asp Trp Asp Glu Asp Met Asp Gly Glu Trp Glu Ala

340 345 350

Pro Gln Ile Ala Asn Pro Arg Cys Glu Ser Ala Pro Gly Cys Gly Val

355 360 365

Trp Gln Arg Pro Val Ile Asp Asn Pro Asn Tyr Lys Gly Lys Trp Lys

370 375 380

Pro Pro Met Ile Asp Asn Pro Ser Tyr Gln Gly Ile Trp Lys Pro Arg

385 390 395 400

Lys Ile Pro Asn Pro Asp Phe Phe Glu Asp Leu Glu Pro Phe Arg Met

405 410 415

Thr Pro Phe Ser Ala Ile Gly Leu Glu Leu Trp Ser Met Thr Ser Asp

420 425 430

Ile Phe Phe Asp Asn Phe Ile Ile Cys Ala Asp Arg Arg Ile Val Asp

435 440 445

Asp Trp Ala Asn Asp Gly Trp Gly Leu Lys Lys Ala Ala Asp Gly Ala

450 455 460

Ala Glu Pro Gly Val Val Gly Gln Met Ile Glu Ala Ala Glu Glu Arg

465 470 475 480

Pro Trp Leu Trp Val Val Tyr Ile Leu Thr Val Ala Leu Pro Val Phe

485 490 495

Leu Val Ile Leu Phe Cys Cys Ser Gly Lys Lys Gln Thr Ser Gly Met

500 505 510

Glu Tyr Lys Lys Thr Asp Ala Pro Gln Pro Asp Val Lys Glu Glu Glu Glu

515 520 525

Glu Glu Lys Glu Glu Glu Lys Asp Lys Gly Asp Glu Glu Glu Glu Gly

530 535 540

Glu Glu Lys Leu Glu Glu Lys Gln Lys Ser Asp Ala Glu Glu Asp Gly

545 550 555 560

Gly Thr Val Ser Gln Glu Glu Glu Asp Arg Lys Pro Lys Ala Glu Glu

565 570 575

Asp Glu Ile Leu Asn Arg Ser Pro Arg Asn Arg Lys Pro Arg Arg Glu

580 585 590

<210>41

<211>282

<212>PRT

<213> Human (Homo sapiens)

<220>

<221> Complement component 1

<222>(1)..(282)

<223> December 9, 2002 Registration number: Q07021

<400>41

Met Leu Pro Leu Leu Arg Cys Val Pro Arg Val Leu Gly Ser Ser Val

1 5 10 15

Ala Gly Leu Arg Ala Ala Ala Pro Ala Ser Pro Phe Arg Gln Leu Leu

20 25 30

Gln Pro Ala Pro Arg Leu Cys Thr Arg Pro Phe Gly Leu Leu Ser Val

35 40 45

Arg Ala Gly Ser Glu Arg Arg Pro Gly Leu Leu Arg Pro Arg Gly Pro

50 55 60

Cys Ala Cys Gly Cys Gly Cys Gly Ser Leu His Thr Asp Gly Asp Lys

65 70 75 80

Ala Phe Val Asp Phe Leu Ser Asp Glu Ile Lys Glu Arg Lys Ile

85 90 95

Gln Lys His Lys Thr Leu Pro Lys Met Ser Gly Gly Trp Glu Leu Glu

100 105 110

Leu Asn Gly Thr Glu Ala Lys Leu Val Arg Lys Val Ala Gly Glu Lys

115 120 125

Ile Thr Val Thr Phe Asn Ile Asn Asn Ser Ile Pro Pro Thr Phe Asp

130 135 140

Gly Glu Glu Glu Pro Ser Gln Gly Gln Lys Val Glu Glu Gln Glu Pro

145 150 155 160

Glu Leu Thr Ser Thr Pro Asn Phe Val Val Glu Val Ile Lys Asn Asp

165 170 175

Asp Gly Lys Lys Ala Leu Val Leu Asp Cys His Tyr Pro Glu Asp Glu

180 185 190

Val Gly Gln Glu Asp Glu Ala Glu Ser Asp Ile Phe Ser Ile Arg Glu

195 200 205

Val Ser Phe Gln Ser Thr Gly Glu Ser Glu Trp Lys Asp Thr Asn Tyr

210 215 220

Thr Leu Asn Thr Asp Ser Leu Asp Trp Ala Leu Tyr Asp His Leu Met

225 230 235 240

Asp Phe Leu Ala Asp Arg Gly Val Asp Asn Thr Phe Ala Asp Glu Leu

245 250 255

Val Glu Leu Ser Thr Ala Leu Glu His Gln Glu Tyr Ile Thr Phe Leu

260 265 270

Glu Asp Leu Lys Ser Phe Val Lys Ser Gln

275 280

<210>42

<211>727

<212>PRT

<213> Human (Homo sapiens)

<220>

<221> Mitochondrial NADH-CoQ oxidoreductase 75kDa subunit precursor

<222>(1)..(727)

<223> December 9, 2002 Registration number: P28331

<400>42

Met Leu Arg Ile Pro Val Arg Arg Ala Leu Val Gly Leu Ser Lys Ser

1 5 10 15

Pro Lys Gly Cys Val Arg Thr Thr Ala Thr Ala Ala Ser Asn Leu Ile

20 25 30

Glu Val Phe Val Asp Gly Gln Ser Val Met Val Glu Pro Gly Thr Thr

35 40 45

Val Leu Gln Ala Cys Glu Lys Val Gly Met Gln Ile Pro Arg Phe Cys

50 55 60

Tyr His Glu Arg Leu Ser Val Ala Gly Asn Cys Arg Met Cys Leu Val

65 70 75 80

Glu Ile Glu Lys Ala Pro Lys Val Val Ala Ala Cys Ala Met Pro Val

85 90 95

Met Lys Gly Trp Asn Ile Leu Thr Asn Ser Glu Lys Ser Lys Lys Ala

100 105 110

Arg Glu Gly Val Met Glu Phe Leu Leu Ala Asn His Pro Leu Asp Cys

115 120 125

Pro Ile Cys Asp Gln Gly Gly Glu Cys Asp Leu Gln Asp Gln Ser Met

130 135 140

Met Phe Gly Asn Asp Arg Ser Arg Phe Leu Glu Gly Lys Arg Ala Val

145 150 155 160

Glu Asp Lys Asn Ile Gly Pro Leu Val Lys Thr Ile Met Thr Arg Cys

165 170 175

Ile Gln Cys Thr Arg Cys Ile Arg Phe Ala Ser Glu Ile Ala Gly Val

180 185 190

Asp Asp Leu Gly Thr Thr Gly Arg Gly Asn Asp Met Gln Val Gly Thr

195 200 205

Tyr Ile Glu Lys Met Phe Met Ser Glu Leu Ser Gly Asn Ile Ile Asp

210 215 220

Ile Cys Pro Val Gly Ala Leu Thr Ser Lys Pro Tyr Ala Phe Thr Ala

225 230 235 240

Arg Pro Trp Glu Thr Arg Lys Thr Glu Ser Ile Asp Val Met Asp Ala

245 250 255

Val Gly Ser Asn Ile Val Val Ser Thr Arg Thr Gly Glu Val Met Arg

260 265 270

Ile Leu Pro Arg Met His Glu Asp Ile Asn Glu Glu Trp Ile Ser Asp

275 280 285

Lys Thr Arg Phe Ala Tyr Asp Gly Leu Lys Arg Gln Arg Leu Thr Glu

290 295 300

Pro Met Val Arg Asn Glu Lys Gly Leu Leu Thr Tyr Thr Ser Trp Glu

305 310 315 320

Asp Ala Leu Ser Arg Val Ala Gly Met Leu Gln Ser Phe Gln Gly Lys

325 330 335

Asp Val Ala Ala Ile Ala Gly Gly Leu Val Asp Ala Glu Ala Leu Val

340 345 350

Ala Leu Lys Asp Leu Leu Asn Arg Val Asp Ser Asp Thr Leu Cys Thr

355 360 365

Glu Glu Val Phe Pro Thr Ala Gly Ala Gly Thr Asp Leu Arg Ser Asn

370 375 380

Tyr Leu Leu Asn Thr Thr Ile Ala Gly Val Glu Glu Ala Asp Val Val

385 390 395 400

Leu Leu Val Gly Thr Asn Pro Arg Phe Glu Ala Pro Leu Phe Asn Ala

405 410 415

Trp Ile Arg Lys Ser Trp Leu His Asn Asp Leu Lys Val Ala Leu Ile

420 425 430

Gly Ser Pro Val Asp Leu Thr Tyr Thr Tyr Asp His Leu Gly Asp Ser

435 440 445

Pro Lys Ile Leu Gln Asp Ile Ala Ser Gly Ser His Pro Phe Ser Gln

450 455 460

Val Leu Lys Glu Ala Lys Lys Pro Met Val Val Leu Gly Ser Ser Ala

465 470 475 480

Leu Gln Arg Asn Asp Gly Ala Ala Ile Leu Ala Ala Val Ser Ser Ile

485 490 495

Ala Gln Lys Ile Arg Met Thr Ser Gly Val Thr Gly Asp Trp Lys Val

500 505 510

Met Asn Ile Leu His Arg Ile Ala Ser Gln Val Ala Ala Leu Asp Leu

515 520 525

Gly Tyr Lys Pro Gly Val Glu Ala Ile Arg Lys Asn Pro Pro Lys Val

530 535 540

Leu Phe Leu Leu Gly Ala Asp Gly Gly Cys Ile Thr Arg Gln Asp Leu

545 550 555 560

Pro Lys Asp Cys Phe Ile Ile Tyr Gln Gly His His Gly Asp Val Gly

565 570 575

Ala Pro Ile Ala Asp Val Ile Leu Pro Gly Ala Ala Tyr Thr Glu Lys

580 585 590

Ser Ala Thr Tyr Val Asn Thr Glu Gly Arg Ala Gln Gln Thr Lys Val

595 600 605

Ala Val Thr Pro Pro Gly Leu Ala Arg Glu Asp Trp Lys Ile Ile Arg

610 615 620

Ala Leu Ser Glu Ile Ala Gly Met Thr Leu Pro Tyr Asp Thr Leu Asp

625 630 635 640

Gln Val Arg Asn Arg Leu Glu Glu Phe Ser Pro Asn Leu Val Arg Tyr

645 650 655

Asp Asp Ile Glu Gly Ala Asn Tyr Phe Gln Gln Ala Asn Glu Leu Ser

660 665 670

Lys Leu Val Asn Gln Gln Leu Leu Ala Asp Pro Leu Val Pro Pro Gln

675 680 685

Leu Thr Leu Lys Asp Phe Tyr Met Thr Asp Ser Ile Ser Arg Ala Ser

690 695 700

Gln Thr Met Ala Lys Cys Val Lys Ala Val Thr Glu Gly Ala Gln Ala

705 710 715 720

Val Glu Glu Pro Ser Ile Cys

725

<210>43

<211>491

<212>PRT

<213> Human (Homo sapiens)

<220>

<221> Pre-B cell enhancer factor precursor

<222>(1)..(491)

<223> December 9, 2002 Registration number: P43490

<400>43

Met Asn Pro Ala Ala Glu Ala Glu Phe Asn Ile Leu Leu Ala Thr Asp

1 5 10 15

Ser Tyr Lys Val Thr His Tyr Lys Gln Tyr Pro Pro Asn Thr Ser Lys

20 25 30

Val Tyr Ser Tyr Phe Glu Cys Arg Glu Lys Lys Thr Glu Asn Ser Lys

35 40 45

Leu Arg Lys Val Lys Tyr Glu Glu Thr Val Phe Tyr Gly Leu Gln Tyr

50 55 60

Ile Leu Asn Lys Tyr Leu Lys Gly Lys Val Val Thr Lys Glu Lys Ile

65 70 75 80

Gln Glu Ala Lys Asp Val Tyr Lys Glu His Phe Gln Asp Asp Val Phe

85 90 95

Asn Glu Lys Gly Trp Asn Tyr Ile Leu Glu Lys Tyr Asp Gly His Leu

100 105 110

Pro Ile Glu Ile Lys Ala Val Pro Glu Gly Phe Val Ile Pro Arg Gly

115 120 125

Asn Val Leu Phe Thr Val Glu Asn Thr Asp Pro Glu Cys Tyr Trp Leu

130 135 140

Thr Asn Trp Ile Glu Thr Ile Leu Val Gln Ser Trp Tyr Pro Ile Thr

145 150 155 160

Val Ala Thr Asn Ser Arg Glu Gln Lys Lys Ile Leu Ala Lys Tyr Leu

165 170 175

Leu Glu Thr Ser Gly Asn Leu Asp Gly Leu Glu Tyr Lys Leu His Asp

180 185 190

Phe Gly Tyr Arg Gly Val Ser Ser Gln Glu Thr Ala Gly Ile Gly Ala

195 200 205

Ser Ala His Leu Val Asn Phe Lys Gly Thr Asp Thr Val Ala Gly Leu

210 215 220

Ala Leu Ile Lys Lys Tyr Tyr Gly Thr Lys Asp Pro Val Pro Gly Tyr

225 230 235 240

Ser Val Pro Ala Ala Glu His Ser Thr Ile Thr Ala Trp Gly Lys Asp

245 250 255

His Glu Lys Asp Ala Phe Glu His Ile Val Thr Gln Phe Ser Ser Val

260 265 270

Pro Val Ser Val Val Ser Asp Ser Tyr Asp Ile Tyr Asn Ala Cys Glu

275 280 285

Lys Ile Trp Gly Glu Asp Leu Arg His Leu Ile Val Ser Arg Ser Thr

290 295 300

Gln Ala Pro Leu Ile Ile Arg Pro Asp Ser Gly Asn Pro Leu Asp Thr

305 310 315 320

Val Leu Lys Val Leu Glu Ile Leu Gly Lys Lys Phe Pro Val Thr Glu

325 330 335

Asn Ser Lys Gly Tyr Lys Leu Leu Pro Pro Tyr Leu Arg Val Ile Gln

340 345 350

Gly Asp Gly Val Asp Ile Asn Thr Leu Gln Glu Ile Val Glu Gly Met

355 360 365

Lys Gln Lys Met Trp Ser Ile Glu Asn Ile Ala Phe Gly Ser Gly Gly

370 375 380

Gly Leu Leu Gln Lys Leu Thr Arg Asp Leu Leu Asn Cys Ser Phe Lys

385 390 395 400

Cys Ser Tyr Val Val Thr Asn Gly Leu Gly Ile Asn Val Phe Lys Asp

405 410 415

Pro Val Ala Asp Pro Asn Lys Arg Ser Lys Lys Gly Arg Leu Ser Leu

420 425 430

His Arg Thr Pro Ala Gly Asn Phe Val Thr Leu Glu Glu Gly Lys Gly

435 440 445

Asp Leu Glu Glu Tyr Gly Gln Asp Leu Leu His Thr Val Phe Lys Asn

450 455 460

Gly Lys Val Thr Lys Ser Tyr Ser Phe Asp Glu Ile Arg Lys Asn Ala

465 470 475 480

Gln Leu Asn Ile Glu Leu Glu Ala Ala His His

485 490

<210>44

<211>135

<212>PRT

<213> Human (Homo sapiens)

<220>

<221> cellular retinol binding protein I

<222>(1)..(135)

<223> December 9, 2002 Registration number: P09455

<400>44

Met Pro Val Asp Phe Thr Gly Tyr Trp Lys Met Leu Val Asn Glu Asn

1 5 10 15

Phe Glu Glu Tyr Leu Arg Ala Leu Asp Val Asn Val Ala Leu Arg Lys

20 25 30

Ile Ala Asn Leu Leu Lys Pro Asp Lys Glu Ile Val Gln Asp Gly Asp

35 40 45

His Met Ile Ile Arg Thr Leu Ser Thr Phe Arg Asn Tyr Ile Met Asp

50 55 60

Phe Gln Val Gly Lys Glu Phe Glu Glu Asp Leu Thr Gly Ile Asp Asp

65 70 75 80

Arg Lys Cys Met Thr Thr Val Ser Trp Asp Gly Asp Lys Leu Gln Cys

85 90 95

Val Gln Lys Gly Glu Lys Glu Gly Arg Gly Trp Thr Gln Trp Ile Glu

100 105 110

Gly Asp Glu Leu His Leu Glu Met Arg Val Glu Gly Val Val Cys Lys

115 120 125

Gln Val Phe Lys Lys Val Gln

130 135

<210>45

<211>544

<212>PRT

<213> Human (Homo sapiens)

<220>

<221> T-complex protein 1, gamma-subunit

<222>(1)..(544)

<223> December 9, 2002 Registration number: P49368

<400>45

Met Gly His Arg Pro Val Leu Val Leu Ser Gln Asn Thr Lys Arg Glu

1 5 10 15

Ser Gly Arg Lys Val Gln Ser Gly Asn Ile Asn Ala Ala Lys Thr Ile

20 25 30

Ala Asp Ile Ile Arg Thr Cys Leu Gly Pro Lys Ser Met Met Lys Met

35 40 45

Leu Leu Asp Pro Met Gly Gly Ile Val Met Thr Asn Asp Gly Asn Ala

50 55 60

Ile Leu Arg Glu Ile Gln Val Gln His Pro Ala Ala Lys Ser Met Ile

65 70 75 80

Glu Ile Ser Arg Thr Gln Asp Glu Glu Val Gly Asp Gly Thr Thr Ser

85 90 95

Val Ile Ile Leu Ala Gly Glu Met Leu Ser Val Ala Glu His Phe Leu

100 105 110

Glu Gln Gln Met His Pro Thr Val Val Ile Ser Ala Tyr Arg Lys Ala

115 120 125

Leu Asp Asp Met Ile Ser Thr Leu Lys Lys Ile Ser Ile Pro Val Asp

130 135 140

Ile Ser Asp Ser Asp Met Met Leu Asn Ile Ile Asn Ser Ser Ile Thr

145 150 155 160

Thr Lys Ala Ile Ser Arg Trp Ser Ser Leu Ala Cys Asn Ile Ala Leu

165 170 175

Asp Ala Val Lys Met Val Gln Phe Glu Glu Asn Gly Arg Lys Glu Ile

180 185 190

Asp Ile Lys Lys Tyr Ala Arg Val Glu Lys Ile Pro Gly Gly Ile Ile

195 200 205

Glu Asp Ser Cys Val Leu Arg Gly Val Met Ile Asn Lys Asp Val Thr

210 215 220

His Pro Arg Met Arg Arg Tyr Ile Lys Asn Pro Arg Ile Val Leu Leu

225 230 235 240

Asp Ser Ser Leu Glu Tyr Lys Lys Gly Glu Ser Gln Thr Asp Ile Glu

245 250 255

Ile Thr Arg Glu Glu Asp Phe Thr Arg Ile Leu Gln Met Glu Glu Glu Glu

260 265 270

Tyr Ile Gln Gln Leu Cys Glu Asp Ile Ile Gln Leu Lys Pro Asp Val

275 280 285

Val Ile Thr Glu Lys Gly Ile Ser Asp Leu Ala Gln His Tyr Leu Met

290 295 300

Arg Ala Asn Ile Thr Ala Ile Arg Arg Val Arg Lys Thr Asp Asn Asn

305 310 315 320

Arg Ile Ala Arg Ala Cys Gly Ala Arg Ile Val Ser Arg Pro Glu Glu Glu

325 330 335

Leu Arg Glu Asp Asp Val Gly Thr Gly Ala Gly Leu Leu Glu Ile Lys

340 345 350

Lys Ile Gly Asp Glu Tyr Phe Thr Phe Ile Thr Asp Cys Lys Asp Pro

355 360 365

Lys Ala Cys Thr Ile Leu Leu Arg Gly Ala Ser Lys Glu Ile Leu Ser

370 375 380

Glu Val Glu Arg Asn Leu Gln Asp Ala Met Gln Val Cys Arg Asn Val

385 390 395 400

Leu Leu Asp Pro Gln Leu Val Pro Gly Gly Gly Ala Ser Glu Met Ala

405 410 415

Val Ala His Ala Leu Thr Glu Lys Ser Lys Ala Met Thr Gly Val Glu

420 425 430

Gln Trp Pro Tyr Arg Ala Val Ala Gln Ala Leu Glu Val Ile Pro Arg

435 440 445

Thr Leu Ile Gln Asn Cys Gly Ala Ser Thr Ile Arg Leu Leu Thr Ser

450 455 460

Leu Arg Ala Lys His Thr Gln Glu Asn Cys Glu Thr Trp Gly Val Asn

465 470 475 480

Gly Glu Thr Gly Thr Leu Val Asp Met Lys Glu Leu Gly Ile Trp Glu

485 490 495

Pro Leu Ala Val Lys Leu Gln Thr Tyr Lys Thr Ala Val Glu Thr Ala

500 505 510

Val Leu Leu Leu Arg Ile Asp Asp Ile Val Ser Gly His Lys Lys Lys

515 520 525

Gly Asp Asp Gln Ser Arg Gln Gly Gly Ala Pro Asp Ala Gly Gln Glu

530 535 540

<210>46

<211>461

<212>PRT

<213> Human (Homo sapiens)

<220>

<221> Placental ribonuclease inhibitors

<222>(1)..(461)

<223> December 9, 2002 Registration number: P13489

<400>46

Met Ser Leu Asp Ile Gln Ser Leu Asp Ile Gln Cys Glu Glu Leu Ser

1 5 10 15

Asp Ala Arg Trp Ala Glu Leu Leu Pro Leu Leu Gln Gln Cys Gln Val

20 25 30

Val Arg Leu Asp Asp Cys Gly Leu Thr Glu Ala Arg Cys Lys Asp Ile

35 40 45

Ser Ser Ala Leu Arg Val Asn Pro Ala Leu Ala Glu Leu Asn Leu Arg

50 55 60

Ser Asn Glu Leu Gly Asp Val Gly Val His Cys Val Leu Gln Gly Leu

65 70 75 80

Gln Thr Pro Ser Cys Lys Ile Gln Lys Leu Ser Leu Gln Asn Cys Cys

85 90 95

Leu Thr Gly Ala Gly Cys Gly Val Leu Ser Ser Thr Leu Arg Thr Leu

100 105 110

Pro Thr Leu Gln Glu Leu His Leu Ser Asp Asn Leu Leu Gly Asp Ala

115 120 125

Gly Leu Gln Leu Leu Cys Glu Gly Leu Leu Asp Pro Gln Cys Arg Leu

130 135 140

Glu Lys Leu Gln Leu Glu Tyr Cys Ser Leu Ser Ala Ala Ser Cys Glu

145 150 155 160

Pro Leu Ala Ser Val Leu Arg Ala Lys Pro Asp Phe Lys Glu Leu Thr

165 170 175

Val Ser Asn Asn Asp Ile Asn Glu Ala Gly Val Arg Val Leu Cys Gln

180 185 190

Gly Leu Lys Asp Ser Pro Cys Gln Leu Glu Ala Leu Lys Leu Glu Ser

195 200 205

Cys Gly Val Thr Ser Asp Asn Cys Arg Asp Leu Cys Gly Ile Val Ala

210 215 220

Ser Lys Ala Ser Leu Arg Glu Leu Ala Leu Gly Ser Asn Lys Leu Gly

225 230 235 240

Asp Val Gly Met Ala Glu Leu Cys Pro Gly Leu Leu His Pro Ser Ser

245 250 255

Arg Leu Arg Thr Leu Trp Ile Trp Glu Cys Gly Ile Thr Ala Lys Gly

260 265 270

Cys Gly Asp Leu Cys Arg Val Leu Arg Ala Lys Glu Ser Leu Lys Glu

275 280 285

Leu Ser Leu Ala Gly Asn Glu Leu Gly Asp Glu Gly Ala Arg Leu Leu

290 295 300

Cys Glu Thr Leu Leu Glu Pro Gly Cys Gln Leu Glu Ser Leu Trp Val

305 310 315 320

Lys Ser Cys Ser Phe Thr Ala Ala Cys Cys Ser His Phe Ser Ser Val

325 330 335

Leu Ala Gln Asn Arg Phe Leu Leu Glu Leu Gln Ile Ser Asn Asn Arg

340 345 350

Leu Glu Asp Ala Gly Val Arg Glu Leu Cys Gln Gly Leu Gly Gln Pro

355 360 365

Gly Ser Val Leu Arg Val Leu Trp Leu Ala Asp Cys Asp Val Ser Asp

370 375 380

Ser Ser Cys Ser Ser Ser Leu Ala Ala Thr Leu Leu Ala Asn His Ser Leu

385 390 395 400

Arg Glu Leu Asp Leu Ser Asn Asn Cys Leu Gly Asp Ala Gly Ile Leu

405 410 415

Gln Leu Val Glu Ser Val Arg Gln Pro Gly Cys Leu Leu Glu Gln Leu

420 425 430

Val Leu Tyr Asp Ile Tyr Trp Ser Glu Glu Met Glu Asp Arg Leu Gln

435 440 445

Ala Leu Glu Lys Asp Lys Pro Ser Leu Arg Val Ile Ser

450 455 460

<210>47

<211>317

<212>PRT

<213> Human (Homo sapiens)

<220>

<221> Guanine-like nucleotide-binding protein beta-subunit protein 12.3

<222>(1)..(317)

<223> December 9, 2002 Registration number: P25388

<400>47

Met Thr Glu Gln Met Thr Leu Arg Gly Thr Leu Lys Gly His Asn Gly

1 5 10 15

Trp Val Thr Gln Ile Ala Thr Thr Pro Gln Phe Pro Asp Met Ile Leu

20 25 30

Ser Ala Ser Arg Asp Lys Thr Ile Ile Met Trp Lys Leu Thr Arg Asp

35 40 45

Glu Thr Asn Tyr Gly Ile Pro Gln Arg Ala Leu Arg Gly His Ser His

50 55 60

Phe Val Ser Asp Val Val Ile Ser Ser Asp Gly Gln Phe Ala Leu Ser

65 70 75 80

Gly Ser Trp Asp Gly Thr Leu Arg Leu Trp Asp Leu Thr Thr Gly Thr

85 90 95

Thr Thr Arg Arg Phe Val Gly His Thr Lys Asp Val Leu Ser Val Ala

100 105 110

Phe Ser Ser Asp Asn Arg Gln Ile Val Ser Gly Ser Arg Asp Lys Thr

115 120 125

Ile Lys Leu Trp Asn Thr Leu Gly Val Cys Lys Tyr Thr Val Gln Asp

130 135 140

Glu Ser His Ser Glu Trp Val Ser Cys Val Arg Phe Ser Pro Asn Ser

145 150 155 160

Ser Asn Pro Ile Ile Val Ser Cys Gly Trp Asp Lys Leu Val Lys Val

165 170 175

Trp Asn Leu Ala Asn Cys Lys Leu Lys Thr Asn His Ile Gly His Thr

180 185 190

Gly Tyr Leu Asn Thr Val Thr Val Ser Pro Asp Gly Ser Leu Cys Ala

195 200 205

Ser Gly Gly Lys Asp Gly Gln Ala Met Leu Trp Asp Leu Asn Glu Gly

210 215 220

Lys His Leu Tyr Thr Leu Asp Gly Gly Asp Ile Ile Asn Ala Leu Cys

225 230 235 240

Phe Ser Pro Asn Arg Tyr Trp Leu Cys Ala Ala Thr Gly Pro Ser Ile

245 250 255

Lys Ile Trp Asp Leu Glu Gly Lys Ile Ile Val Asp Glu Leu Lys Gln

260 265 270

Glu Val Ile Ser Thr Ser Ser Lys Ala Glu Pro Pro Gln Cys Thr Ser

275 280 285

Leu Ala Trp Ser Ala Asp Gly Gln Thr Leu Phe Ala Gly Tyr Thr Asp

290 295 300

Asn Leu Val Arg Val Trp Gln Val Thr Ile Gly Thr Arg

305 310 315

<210>48

<211>172

<212>PRT

<213> Human (Homo sapiens)

<220>

<221> Myosin-regulated light chain 2

<222>(1)..(172)

<223> December 9, 2002 Registration number: P24844

<400>48

Met Ser Ser Lys Arg Ala Lys Ala Lys Thr Thr Lys Lys Arg Pro Gln

1 5 10 15

Arg Ala Thr Ser Asn Val Phe Ala Met Phe Asp Gln Ser Gln Ile Gln

20 25 30

Glu Phe Lys Glu Ala Phe Asn Met Ile Asp Gln Asn Arg Asp Gly Phe

35 40 45

Ile Asp Lys Glu Asp Leu His Asp Met Leu Ala Ser Leu Gly Lys Asn

50 55 60

Pro Thr Asp Glu Tyr Leu Glu Gly Met Met Ser Glu Ala Pro Gly Pro

65 70 75 80

Ile Asn Phe Thr Met Phe Leu Thr Met Phe Gly Glu Lys Leu Asn Gly

85 90 95

Thr Asp Pro Glu Asp Val Ile Arg Asn Ala Phe Ala Cys Phe Asp Glu

100 105 110

Glu Ala Ser Gly Phe Ile His Glu Asp His Leu Arg Glu Leu Leu Thr

115 120 125

Thr Met Gly Asp Arg Phe Thr Asp Glu Glu Val Asp Glu Met Tyr Arg

130 135 140

Glu Ala Pro Ile Asp Lys Lys Gly Asn Phe Asn Tyr Val Glu Phe Thr

145 150 155 160

Arg Ile Leu Lys His Gly Ala Lys Asp Lys Asp Asp

165 170

<210>49

<211>114

<212>PRT

<213> Human (Homo sapiens)

<220>

<221> Calgranulin B

<222>(1)..(114)

<223> December 10, 2002 Registration number: P06702

<400>49

Met Thr Cys Lys Met Ser Gln Leu Glu Arg Asn Ile Glu Thr Ile Ile

1 5 10 15

Asn Thr Phe His Gln Tyr Ser Val Lys Leu Gly His Pro Asp Thr Leu

20 25 30

Asn Gln Gly Glu Phe Lys Glu Leu Val Arg Lys Asp Leu Gln Asn Phe

35 40 45

Leu Lys Lys Glu Asn Lys Asn Glu Lys Val Ile Glu His Ile Met Glu

50 55 60

Asp Leu Asp Thr Asn Ala Asp Lys Gln Leu Ser Phe Glu Glu Phe Ile

65 70 75 80

Met Leu Met Ala Arg Leu Thr Trp Ala Ser His Glu Lys Met His Glu

85 90 95

Gly Asp Glu Gly Pro Gly His His His Lys Pro Gly Leu Gly Glu Gly

100 105 110

Thr Pro

<210>50

<211>348

<212>PRT

<213> Human (Homo sapiens)

<220>

<221> Macrophage capping protein

<222>(1)..(348)

<223> December 10, 2002 Registration number: P40121

<400>50

Met Tyr Thr Ala Ile Pro Gln Ser Gly Ser Pro Phe Pro Gly Ser Val

1 5 10 15

Gln Asp Pro Gly Leu His Val Trp Arg Val Glu Lys Leu Lys Pro Val

20 25 30

Pro Val Ala Gln Glu Asn Gln Gly Val Phe Phe Ser Gly Asp Ser Tyr

35 40 45

Leu Val Leu His Asn Gly Pro Glu Glu Val Ser His Leu His Leu Trp

50 55 60

Ile Gly Gln Gln Ser Ser Arg Asp Glu Gln Gly Ala Cys Ala Val Leu

65 70 75 80

Ala Val His Leu Asn Thr Leu Leu Gly Glu Arg Pro Val Gln His Arg

85 90 95

Glu Val Gln Gly Asn Glu Ser Asp Leu Phe Met Ser Tyr Phe Pro Arg

100 105 110

Gly Leu Lys Tyr Gln Glu Gly Gly Val Glu Ser Ala Phe His Lys Thr

115 120 125

Ser Thr Gly Ala Pro Ala Ala Ile Lys Lys Leu Tyr Gln Val Lys Gly

130 135 140

Lys Lys Asn Ile Arg Ala Thr Glu Arg Ala Leu Asn Trp Asp Ser Phe

145 150 155 160

Asn Thr Gly Asp Cys Phe Ile Leu Asp Leu Gly Gln Asn Ile Phe Ala

165 170 175

Trp Cys Gly Gly Lys Ser Asn Ile Leu Glu Arg Asn Lys Ala Arg Asp

180 185 190

Leu Ala Leu Ala Ile Arg Asp Ser Glu Arg Gln Gly Lys Ala Gln Val

195 200 205

Glu Ile Val Thr Asp Gly Glu Glu Pro Ala Glu Met Ile Gln Val Leu

210 215 220

Gly Pro Lys Pro Ala Leu Lys Glu Gly Asn Pro Glu Glu Asp Leu Thr

225 230 235 240

Ala Asp Lys Ala Asn Ala Gln Ala Ala Ala Leu Tyr Lys Val Ser Asp

245 250 255

Ala Thr Gly Gln Met Asn Leu Thr Lys Val Ala Asp Ser Ser Pro Phe

260 265 270

Ala Leu Glu Leu Leu Ile Ser Asp Asp Cys Phe Val Leu Asp Asn Gly

275 280 285

Leu Cys Gly Lys Ile Tyr Ile Trp Lys Gly Arg Lys Ala Asn Glu Lys

290 295 300

Glu Arg Gln Ala Ala Leu Gln Val Ala Glu Gly Phe Ile Ser Arg Met

305 310 315 320

Gln Tyr Ala Pro Asn Thr Gln Val Glu Ile Leu Pro Gln Gly Arg Glu

325 330 335

Ser Pro Ile Phe Lys Gln Phe Phe Lys Asp Trp Lys

340 345

<210>51

<211>346

<212>PRT

<213> Human (Homo sapiens)

<220>

<221> Annexin I

<222>(1)..(346)

<223> December 10, 2002 Registration number: P04083

<400>51

Met Ala Met Val Ser Glu Phe Leu Lys Gln Ala Trp Phe Ile Glu Asn

1 5 10 15

Glu Glu Gln Glu Tyr Val Gln Thr Val Lys Ser Ser Lys Gly Gly Pro

20 25 30

Gly Ser Ala Val Ser Pro Tyr Pro Thr Phe Asn Pro Ser Ser Asp Val

35 40 45

Ala Ala Leu His Lys Ala Ile Met Val Lys Gly Val Asp Glu Ala Thr

50 55 60

Ile Ile Asp Ile Leu Thr Lys Arg Asn Asn Ala Gln Arg Gln Gln Ile

65 70 75 80

Lys Ala Ala Tyr Leu Gln Glu Thr Gly Lys Pro Leu Asp Glu Thr Leu

85 90 95

Lys Lys Ala Leu Thr Gly His Leu Glu Glu Val Val Leu Ala Leu Leu

100 105 110

Lys Thr Pro Ala Gln Phe Asp Ala Asp Glu Leu Arg Ala Ala Met Lys

115 120 125

Gly Leu Gly Thr Asp Glu Asp Thr Leu Ile Glu Ile Leu Ala Ser Arg

130 135 140

Thr Asn Lys Glu Ile Arg Asp Ile Asn Arg Val Tyr Arg Glu Glu Leu

145 150 155 160

Lys Arg Asp Leu Ala Lys Asp Ile Thr Ser Asp Thr Ser Gly Asp Phe

165 170 175

Arg Asn Ala Leu Leu Ser Leu Ala Lys Gly Asp Arg Ser Glu Asp Phe

180 185 190

Gly Val Asn Glu Asp Leu Ala Asp Ser Asp Ala Arg Ala Leu Tyr Glu

195 200 205

Ala Gly Glu Arg Arg Lys Gly Thr Asp Val Asn Val Phe Asn Thr Ile

210 215 220

Leu Thr Thr Arg Ser Tyr Pro Gln Leu Arg Arg Val Phe Gln Lys Tyr

225 230 235 240

Thr Lys Tyr Ser Lys His Asp Met Asn Lys Val Leu Asp Leu Glu Leu

245 250 255

Lys Gly Asp Ile Glu Lys Cys Leu Thr Ala Ile Val Lys Cys Ala Thr

260 265 270

Ser Lys Pro Ala Phe Phe Ala Glu Lys Leu His Gln Ala Met Lys Gly

275 280 285

Val Gly Thr Arg His Lys Ala Leu Ile Arg Ile Met Val Ser Arg Ser

290 295 300

Glu Ile Asp Met Asn Asp Ile Lys Ala Phe Tyr Gln Lys Met Tyr Gly

305 310 315 320

Ile Ser Leu Cys Gln Ala Ile Leu Asp Glu Thr Lys Gly Asp Tyr Glu

325 330 335

Lys Ile Leu Val Ala Leu Cys Gly Gly Asn

340 345

<210>52

<211>469

<212>PRT

<213> Human (Homo sapiens)

<220>

<221> Type II cytoskeleton 7 keratin

<222>(1)..(469)

<223> December 10, 2002 Registration number: P08729

<400>52

Met Ser Ile His Phe Ser Ser Pro Val Phe Thr Ser Arg Ser Ala Ala

1 5 10 15

Phe Ser Gly Arg Gly Ala Gln Val Arg Leu Ser Ser Ala Arg Pro Gly

20 25 30

Gly Leu Gly Ser Ser Ser Leu Tyr Gly Leu Gly Ala Ser Arg Pro Arg

35 40 45

Val Ala Val Arg Ser Ala Tyr Gly Gly Pro Val Gly Ala Gly Ile Arg

50 55 60

Glu Val Thr Ile Asn Gln Ser Leu Leu Ala Pro Leu Arg Leu Asp Ala

65 70 75 80

Asp Pro Ser Leu Gln Arg Val Arg Gln Glu Glu Ser Glu Gln Ile Lys

85 90 95

Thr Leu Asn Asn Lys Phe Ala Ser Phe Ile Asp Lys Val Arg Phe Leu

100 105 110

Glu Gln Gln Asn Lys Leu Leu Glu Thr Lys Trp Thr Leu Leu Gln Glu

115 120 125

Gln Lys Ser Ala Lys Ser Ser Arg Leu Pro Asp Ile Phe Glu Ala Gln

130 135 140

Ile Ala Gly Leu Arg Gly Gln Leu Glu Ala Leu Gln Val Asp Gly Gly

145 150 155 160

Arg Leu Glu Gln Gly Leu Arg Thr Met Gln Asp Val Val Glu Asp Phe

165 170 175

Lys Asn Lys Tyr Glu Asp Glu Ile Asn Arg Arg Thr Ala Ala Glu Asn

180 185 190

Glu Phe Val Val Leu Lys Lys Asp Val Asp Ala Ala Tyr Met Ser Lys

195 200 205

Val Glu Leu Glu Ala Lys Val Asp Ala Leu Asn Asp Glu Ile Asn Phe

210 215 220

Leu Arg Thr Leu Asn Glu Thr Glu Leu Thr Glu Leu Gln Ser Gln Ile

225 230 235 240

Ser Asp Thr Ser Val Val Leu Ser Met Asp Asn Ser Arg Ser Leu Asp

245 250 255

Leu Asp Gly Ile Ile Ala Glu Val Lys Ala Gln Tyr Glu Glu Met Ala

260 265 270

Lys Cys Ser Arg Ala Glu Ala Glu Ala Trp Tyr Gln Thr Lys Phe Glu

275 280 285

Thr Leu Gln Ala Gln Ala Gly Lys His Gly Asp Asp Leu Arg Asn Thr

290 295 300

Arg Asn Glu Ile Ser Glu Met Asn Arg Ala Ile Gln Arg Leu Gln Ala

305 310 315 320

Glu Ile Asp Asn Ile Lys Asn Gln Arg Ala Lys Leu Glu Ala Ala Ile

325 330 335

Ala Glu Ala Glu Glu Arg Gly Glu Leu Ala Leu Lys Asp Ala Arg Ala

340 345 350

Lys Gln Glu Glu Leu Glu Ala Ala Leu Gln Arg Ala Lys Gln Asp Met

355 360 365

Ala Arg Gln Leu Arg Glu Tyr Gln Glu Leu Met Ser Val Lys Leu Ala

370 375 380

Leu Asp Ile Glu Ile Ala Thr Tyr Arg Lys Leu Leu Glu Gly Glu Glu

385 390 395 400

Ser Arg Leu Ala Gly Asp Gly Val Gly Ala Val Asn Ile Ser Val Met

405 410 415

Asn Ser Thr Gly Gly Ser Ser Ser Ser Gly Gly Gly Ile Gly Leu Thr Leu

420 425 430

Gly Gly Thr Met Gly Ser Asn Ala Leu Ser Phe Ser Ser Ser Ala Gly

435 440 445

Pro Gly Leu Leu Lys Ala Tyr Ser Ile Arg Thr Ala Ser Ala Ser Arg

450 455 460

Arg Ser Ala Arg Asp

465

<210>53

<211>836

<212>PRT

<213> Human (Homo sapiens)

<220>

<221> osteoblast-specific factor 2 precursor

<222>(1)..(836)

<223> December 10, 2002 Registration number: Q15063

<400>53

Met Ile Pro Phe Leu Pro Met Phe Ser Leu Leu Leu Leu Leu Ile Val

1 5 10 15

Asn Pro Ile Asn Ala Asn Asn His Tyr Asp Lys Ile Leu Ala His Ser

20 25 30

Arg Ile Arg Gly Arg Asp Gln Gly Pro Asn Val Cys Ala Leu Gln Gln

35 40 45

Ile Leu Gly Thr Lys Lys Lys Tyr Phe Ser Thr Cys Lys Asn Trp Tyr

50 55 60

Lys Lys Ser Ile Cys Gly Gln Lys Thr Thr Val Leu Tyr Glu Cys Cys

65 70 75 80

Pro Gly Tyr Met Arg Met Glu Gly Met Lys Gly Cys Pro Ala Val Leu

85 90 95

Pro Ile Asp His Val Tyr Gly Thr Leu Gly Ile Val Gly Ala Thr Thr

100 105 110

Thr Gln Arg Tyr Ser Asp Ala Ser Lys Leu Arg Glu Glu Ile Glu Gly

115 120 125

Lys Gly Ser Phe Thr Tyr Phe Ala Pro Ser Asn Glu Ala Trp Asp Asn

130 135 140

Leu Asp Ser Asp Ile Arg Arg Gly Leu Glu Ser Asn Val Asn Val Glu

145 150 155 160

Leu Leu Asn Ala Leu His Ser His Met Ile Asn Lys Arg Met Leu Thr

165 170 175

Lys Asp Leu Lys Asn Gly Met Ile Ile Pro Ser Met Tyr Asn Asn Leu

180 185 190

Gly Leu Phe Ile Asn His Tyr Pro Asn Gly Val Val Thr Val Asn Cys

195 200 205

Ala Arg Ile Ile His Gly Asn Gln Ile Ala Thr Asn Gly Val Val His

210 215 220

Val Ile Asp Arg Val Leu Thr Gln Ile Gly Thr Ser Ile Gln Asp Phe

225 230 235 240

Ile Glu Ala Glu Asp Asp Leu Ser Ser Phe Arg Ala Ala Ala Ile Thr

245 250 255

Ser Asp Ile Leu Glu Ala Leu Gly Arg Asp Gly His Phe Thr Leu Phe

260 265 270

Ala Pro Thr Asn Glu Ala Phe Glu Lys Leu Pro Arg Gly Val Leu Glu

275 280 285

Arg Phe Met Gly Asp Lys Val Ala Ser Glu Ala Leu Met Lys Tyr His

290 295 300

Ile Leu Asn Thr Leu Gln Cys Ser Glu Ser Ile Met Gly Gly Ala Val

305 310 315 320

Phe Glu Thr Leu Glu Gly Asn Thr Ile Glu Ile Gly Cys Asp Gly Asp

325 330 335

Ser Ile Thr Val Asn Gly Ile Lys Met Val Asn Lys Lys Asp Ile Val

340 345 350

Thr Asn Asn Gly Val Ile His Leu Ile Asp Gln Val Leu Ile Pro Asp

355 360 365

Ser Ala Lys Gln Val Ile Glu Leu Ala Gly Lys Gln Gln Thr Thr Phe

370 375 380

Thr Asp Leu Val Ala Gln Leu Gly Leu Ala Ser Ala Leu Arg Pro Asp

385 390 395 400

Gly Glu Tyr Thr Leu Leu Ala Pro Val Asn Asn Ala Phe Ser Asp Asp

405 410 415

Thr Leu Ser Met Val Gln Arg Leu Leu Lys Leu Ile Leu Gln Asn His

420 425 430

Ile Leu Lys Val Lys Val Gly Leu Asn Glu Leu Tyr Asn Gly Gln Ile

435 440 445

Leu Glu Thr Ile Gly Gly Lys Gln Leu Arg Val Phe Val Tyr Arg Thr

450 455 460

Ala Val Cys Ile Glu Asn Ser Cys Met Glu Lys Gly Ser Lys Gln Gly

465 470 475 480

Arg Asn Gly Ala Ile His Ile Phe Arg Glu Ile Ile Lys Pro Ala Glu

485 490 495

Lys Ser Leu His Glu Lys Leu Lys Gln Asp Lys Arg Phe Ser Thr Phe

500 505 510

Leu Ser Leu Leu Glu Ala Ala Asp Leu Lys Glu Leu Leu Thr Gln Pro

515 520 525

Gly Asp Trp Thr Leu Phe Val Pro Thr Asn Asp Ala Phe Lys Gly Met

530 535 540

Thr Ser Glu Glu Lys Glu Ile Leu Ile Arg Asp Lys Asn Ala Leu Gln

545 550 555 560

Asn Ile Ile Leu Tyr His Leu Thr Pro Gly Val Phe Ile Gly Lys Gly

565 570 575

Phe Glu Pro Gly Val Thr Asn Ile Leu Lys Thr Thr Gln Gly Ser Lys

580 585 590

Ile Phe Leu Lys Glu Val Asn Asp Thr Leu Leu Val Asn Glu Leu Lys

595 600 605

Ser Lys Glu Ser Asp Ile Met Thr Thr Asn Gly Val Ile His Val Val

610 615 620

Asp Lys Leu Leu Tyr Pro Ala Asp Thr Pro Val Gly Asn Asp Gln Leu

625 630 635 640

Leu Glu Ile Leu Asn Lys Leu Ile Lys Tyr Ile Gln Ile Lys Phe Val

645 650 655

Arg Gly Ser Thr Phe Lys Glu Ile Pro Val Thr Val Tyr Thr Thr Lys

660 665 670

Ile Ile Thr Lys Val Val Glu Pro Lys Ile Lys Val Ile Glu Gly Ser

675 680 685

Leu Gln Pro Ile Ile Lys Thr Glu Gly Pro Thr Leu Thr Lys Val Lys

690 695 700

Ile Glu Gly Glu Pro Glu Phe Arg Leu Ile Lys Glu Gly Glu Thr Ile

705 710 715 720

Thr Glu Val Ile His Gly Glu Pro Ile Ile Lys Lys Tyr Thr Lys Ile

725 730 735

Ile Asp Gly Val Pro Val Glu Ile Thr Glu Lys Glu Thr Arg Glu Glu

740 745 750

Arg Ile Ile Thr Gly Pro Glu Ile Lys Tyr Thr Arg Ile Ser Thr Gly

755 760 765

Gly Gly Glu Thr Glu Glu Thr Leu Lys Lys Leu Leu Gln Glu Glu Val

770 775 780

Thr Lys Val Thr Lys Phe Ile Glu Gly Gly Asp Gly His Leu Phe Glu

785 790 795 800

Asp Glu Glu lle Lys Arg Leu Leu Gln Gly Asp Thr Pro Val Arg Lys

805 810 815

Leu Gln Ala Asn Lys Lys Val Gln Gly Ser Arg Arg Arg Leu Arg Glu

820 825 830

Gly Arg Ser Gln

835

<210>54

<211>687

<212>PRT

<213> Human (Homo sapiens)

<220>

<221> protein-glutamine gamma-glutamyltransferase

<222>(1)..(687)

<223> Registration No. P21980

<400>54

Met Ala Glu Glu Leu Val Leu Glu Arg Cys Asp Leu Glu Leu Glu Thr

1 5 10 15

Asn Gly Arg Asp His His Thr Ala Asp Leu Cys Arg Glu Lys Leu Val

20 25 30

Val Arg Arg Gly Gln Pro Phe Trp Leu Thr Leu His Phe Glu Gly Arg

35 40 45

Asn Tyr Glu Ala Ser Val Asp Ser Leu Thr Phe Ser Val Val Thr Gly

50 55 60

Pro Ala Pro Ser Gln Glu Ala Gly Thr Lys Ala Arg Phe Pro Leu Arg

65 70 75 80

Asp Ala Val Glu Glu Gly Asp Trp Thr Ala Thr Val Val Asp Gln Gln

85 90 95

Asp Cys Thr Leu Ser Leu Gln Leu Thr Thr Pro Ala Asn Ala Pro Ile

100 105 110

Gly Leu Tyr Arg Leu Ser Leu Glu Ala Ser Thr Gly Tyr Gln Gly Ser

115 120 125

Ser Phe Val Leu Gly His Phe Ile Leu Leu Phe Asn Ala Trp Cys Pro

130 135 140

Ala Asp Ala Val Tyr Leu Asp Ser Glu Glu Glu Arg Gln Glu Tyr Val

145 150 155 160

Leu Thr Gln Gln Gly Phe Ile Tyr Gln Gly Ser Ala Lys Phe Ile Lys

165 170 175

Asn Ile Pro Trp Asn Phe Gly Gln Phe Glu Asp Gly Ile Leu Asp Ile

180 185 190

Cys Leu Ile Leu Leu Asp Val Asn Pro Lys Phe Leu Lys Asn Ala Gly

195 200 205

Arg Asp Cys Ser Arg Arg Ser Ser Pro Val Tyr Val Gly Arg Val Val

210 215 220

Ser Gly Met Val Asn Cys Asn Asp Asp Gln Gly Val Leu Leu Gly Arg

225 230 235 240

Trp Asp Asn Asn Tyr Gly Asp Gly Val Ser Pro Met Ser Trp Ile Gly

245 250 255

Ser Val Asp Ile Leu Arg Arg Trp Lys Asn His Gly Cys Gln Arg Val

260 265 270

Lys Tyr Gly Gln Cys Trp Val Phe Ala Ala Val Ala Cys Thr Val Leu

275 280 285

Arg Cys Leu Gly Ile Pro Thr Arg Val Val Thr Asn Tyr Asn Ser Ala

290 295 300

His Asp Gln Asn Ser Asn Leu Leu Ile Glu Tyr Phe Arg Asn Glu Phe

305 310 315 320

Gly Glu Ile Gln Gly Asp Lys Ser Glu Met Ile Trp Asn Phe His Cys

325 330 335

Trp Val Glu Ser Trp Met Thr Arg Pro Asp Leu Gln Pro Gly Tyr Glu

340 345 350

Gly Trp Gln Ala Leu Asp Pro Thr Pro Gln Glu Lys Ser Glu Gly Thr

355 360 365

Tyr Cys Cys Gly Pro Val Pro Val Arg Ala Ile Lys Glu Gly Asp Leu

370 375 380

Ser Thr Lys Tyr Asp Ala Pro Phe Val Phe Ala Glu Val Asn Ala Asp

385 390 395 400

Val Val Asp Trp Ile Gln Gln Asp Asp Gly Ser Val His Lys Ser Ile

405 410 415

Asn Arg Ser Leu Ile Val Gly Leu Lys Ile Ser Thr Lys Ser Val Gly

420 425 430

Arg Asp Glu Arg Glu Asp Ile Thr His Thr Tyr Lys Tyr Pro Glu Gly

435 440 445

Ser Ser Glu Glu Arg Glu Ala Phe Thr Arg Ala Asn His Leu Asn Lys

450 455 460

Leu Ala Glu Lys Glu Glu Thr Gly Met Ala Met Arg Ile Arg Val Gly

465 470 475 480

Gln Ser Met Asn Met Gly Ser Asp Phe Asp Val Phe Ala His Ile Thr

485 490 495

Asn Asn Thr Ala Glu Glu Tyr Val Cys Arg Leu Leu Leu Cys Ala Arg

500 505 510

Thr Val Ser Tyr Asn Gly Ile Leu Gly Pro Glu Cys Gly Thr Lys Tyr

515 520 525

Leu Leu Asn Leu Asn Leu Glu Pro Phe Ser Glu Lys Ser Val Pro Leu

530 535 540

Cys Ile Leu Tyr Glu Lys Tyr Arg Asp Cys Leu Thr Glu Ser Asn Leu

545 550 555 560

Ile Lys Val Arg Ala Leu Leu Val Glu Pro Val Ile Asn Ser Tyr Leu

565 570 575

Leu Ala Glu Arg Asp Leu Tyr Leu Glu Asn Pro Glu Ile Lys Ile Arg

580 585 590

Ile Leu Gly Glu Pro Lys Gln Lys Arg Lys Leu Val Ala Glu Val Ser

595 600 605

Leu Gln Asn Pro Leu Pro Val Ala Leu Glu Gly Cys Thr Phe Thr Val

610 615 620

Glu Gly Ala Gly Leu Thr Glu Glu Gln Lys Thr Val Glu Ile Pro Asp

625 630 635 640

Pro Val Glu Ala Gly Glu Glu Val Lys Val Arg Met Asp Leu Leu Pro

645 650 655

Leu His Met Gly Leu His Lys Leu Val Val Asn Phe Glu Ser Asp Lys

660 665 670

Leu Lys Ala Val Lys Gly Phe Arg Asn Val Ile Ile Gly Pro Ala

675 680 685

<210>55

<211>204

<212>PRT

<213> Human (Homo sapiens)

<220>

<221> Rho GDP-Dissociation Inhibitor 1

<222>(1)..(204)

<223> December 10, 2002 Registration number: P52565

<400>55

Met Ala Glu Gln Glu Pro Thr Ala Glu Gln Leu Ala Gln Ile Ala Ala

1 5 10 15

Glu Asn Glu Glu Asp Glu His Ser Val Asn Tyr Lys Pro Pro Ala Gln

20 25 30

Lys Ser Ile Gln Glu Ile Gln Glu Leu Asp Lys Asp Asp Glu Ser Leu

35 40 45

Arg Lys Tyr Lys Glu Ala Leu Leu Gly Arg Val Ala Val Ser Ala Asp

50 55 60

Pro Asn Val Pro Asn Val Val Val Thr Gly Leu Thr Leu Val Cys Ser

65 70 75 80

Ser Ala Pro Gly Pro Leu Glu Leu Asp Leu Thr Gly Asp Leu Glu Ser

85 90 95

Phe Lys Lys Gln Ser Phe Val Leu Lys Glu Gly Val Glu Tyr Arg Ile

100 105 110

Lys Ile Ser Phe Arg Val Asn Arg Glu Ile Val Ser Gly Met Lys Tyr

115 120 125

Ile Gln His Thr Tyr Arg Lys Gly Val Lys Ile Asp Lys Thr Asp Tyr

130 135 140

Met Val Gly Ser Tyr Gly Pro Arg Ala Glu Glu Tyr Glu Phe Leu Thr

145 150 155 160

Pro Val Glu Glu Ala Pro Lys Gly Met Leu Ala Arg Gly Ser Tyr Ser

165 170 175

Ile Lys Ser Arg Phe Thr Asp Asp Asp Lys Thr Asp His Leu Ser Trp

180 185 190

Glu Trp Asn Leu Thr Ile Lys Lys Asp Trp Lys Asp

195 200

<210>56

<211>492

<212>PRT

<213> Human (Homo sapiens)

<220>

<221> fascin 2

<222>(1)..(492)

<223> August 29, 2003 Registration number: 014926

<400>56

Met Pro Thr Asn Gly Leu His Gln Val Leu Lys Ile Gln Phe Gly Leu

1 5 10 15

Val Asn Asp Thr Asp Arg Tyr Leu Thr Ala Glu Ser Phe Gly Phe Lys

20 25 30

Val Asn Ala Ser Ala Pro Ser Leu Lys Arg Lys Gln Thr Trp Val Leu

35 40 45

Glu Pro Asp Pro Gly Gln Gly Thr Ala Val Leu Leu Arg Ser Ser His

50 55 60

Leu Gly Arg Tyr Leu Ser Ala Glu Glu Asp Gly Arg Val Ala Cys Glu

65 70 75 80

Ala Glu Gln Pro Gly Arg Asp Cys Arg Phe Leu Val Leu Pro Gln Pro

85 90 95

Asp Gly Arg Trp Val Leu Arg Ser Glu Pro His Gly Arg Phe Phe Gly

100 105 110

Gly Thr Glu Asp Gln Leu Ser Cys Phe Ala Thr Ala Val Ser Pro Ala

115 120 125

Glu Leu Trp Thr Val His Leu Ala Ile His Pro Gln Ala His Leu Leu

130 135 140

Ser Val Ser Arg Arg Arg Tyr Val His Leu Cys Pro Arg Glu Asp Glu

145 150 155 160

Met Ala Ala Asp Gly Asp Lys Pro Trp Gly Val Asp Ala Leu Leu Thr

165 170 175

Leu lle Phe Arg Ser Arg Arg Tyr Cys Leu Lys Ser Cys Asp Ser Arg

180 185 190

Tyr Leu Arg Ser Asp Gly Arg Leu Val Trp Glu Pro Glu Pro Arg Ala

195 200 205

Cys Tyr Thr Leu Glu Phe Lys Ala Gly Lys Leu Ala Phe Lys Asp Cys

210 215 220

Asp Gly His Tyr Leu Ala Pro Val Gly Pro Ala Gly Thr Leu Lys Ala

225 230 235 240

Gly Arg Asn Thr Arg Pro Gly Lys Asp Glu Leu Phe Asp Leu Glu Glu

245 250 255

Ser His Pro Gln Val Val Leu Val Ala Ala Asn His Arg Tyr Val Ser

260 265 270

Val Arg Gln Gly Val Asn Val Ser Ala Asn Gln Asp Asp Glu Leu Asp

275 280 285

His Glu Thr Phe Leu Met Gln Ile Asp Gln Glu Thr Lys Lys Cys Thr

290 295 300

Phe Tyr Ser Ser Thr Gly Gly Tyr Trp Thr Leu Val Thr His Gly Gly

305 310 315 320

Ile His Ala Thr Ala Thr Gln Val Ser Ala Asn Thr Met Phe Glu Met

325 330 335

Glu Trp Arg Gly Arg Arg Val Ala Leu Lys Ala Ser Asn Gly Arg Tyr

340 345 350

Val Cys Met Lys Lys Asn Gly Gln Leu Ala Ala Ile Ser Asp Phe Val

355 360 365

Gly Lys Asp Glu Glu Phe Thr Leu Lys Leu Ile Asn Arg Pro Ile Leu

370 375 380

Val Leu Arg Gly Leu Asp Gly Phe Val Cys His His Arg Gly Ser Asn

385 390 395 400

Gln Leu Asp Thr Asn Arg Ser Val Tyr Asp Val Phe His Leu Ser Phe

405 410 415

Ser Asp Gly Ala Tyr Arg Ile Arg Gly Arg Asp Gly Gly Phe Trp Tyr

420 425 430

Thr Gly Ser His Gly Ser Val Cys Ser Asp Gly Glu Arg Ala Glu Asp

435 440 445

Phe Val Phe Glu Phe Arg Glu Arg Gly Arg Leu Ala Ile Arg Ala Arg

450 455 460

Ser Gly Lys Tyr Leu Arg Gly Gly Ala Ser Gly Leu Leu Arg Ala Asp

465 470 475 480

Ala Asp Ala Pro Ala Gly Thr Ala Leu Trp Glu Tyr

485 490

<210>57

<211>165

<212>PRT

<213> Human (Homo sapiens)

<220>

<221>Destrin (Actin Depolymerization Factor) (ADF)

<222>(1)..(165)

<223> August 29, 2003 Registration number: P18282

<400>57

Met Ala Ser Gly Val Gln Val Ala Asp Glu Val Cys Arg Ile Phe Tyr

1 5 10 15

Asp Met Lys Val Arg Lys Cys Ser Thr Pro Glu Glu Ile Lys Lys Arg

20 25 30

Lys Lys Ala Val Ile Phe Cys Leu Ser Ala Asp Lys Lys Cys Ile Ile

35 40 45

Val Glu Glu Gly Lys Glu Ile Leu Val Gly Asp Val Gly Val Thr Ile

50 55 60

Thr Asp Pro Phe Lys His Phe Val Gly Met Leu Pro Glu Lys Asp Cys

65 70 75 80

Arg Tyr Ala Leu Tyr Asp Ala Ser Phe Glu Thr Lys Glu Ser Arg Lys

85 90 95

Glu Glu Leu Met Phe Phe Leu Trp Ala Pro Glu Leu Ala Pro Leu Lys

100 105 110

Ser Lys Met Ile Tyr Ala Ser Ser Lys Asp Ala Ile Lys Lys Lys Phe

115 120 125

Gln Gly Ile Lys His Glu Cys Gln Ala Asn Gly Pro Glu Asp Leu Asn

130 135 140

Arg Ala Cys Ile Ala Glu Lys Leu Gly Gly Ser Leu Ile Val Ala Phe

145 150 155 160

Glu Gly Cys Pro Val

165

<210>58

<211>492

<212>PRT

<213> Human (Homo sapiens)

<220>

<221> fascin

<222>(1)..(492)

<223> August 29, 2003 Registration number: Q16658

<400>58

Thr Ala Asn Gly Thr Ala Glu Ala Val Gln Ile Gln Phe Gly Leu Ile

1 5 10 15

Asn Cys Gly Asn Lys Tyr Leu Thr Ala Glu Ala Phe Gly Phe Lys Val

20 25 30

Asn Ala Ser Ala Ser Ser Leu Lys Lys Lys Gln Ile Trp Thr Leu Glu

35 40 45

Gln Pro Pro Asp Glu Ala Gly Ser Ala Ala Val Cys Leu Arg Ser His

50 55 60

Leu Gly Arg Tyr Leu Ala Ala Asp Lys Asp Gly Asn Val Thr Cys Glu

65 70 75 80

Arg Glu Val Pro Gly Pro Asp Cys Arg Phe Leu Ile Val Ala His Asp

85 90 95

Asp Gly Arg Trp Ser Leu Gln Ser Glu Ala His Arg Arg Tyr Phe Gly

100 105 110

Gly Thr Glu Asp Arg Leu Ser Cys Phe Ala Gln Thr Val Ser Pro Ala

115 120 125

Glu Lys Trp Ser Val His Ile Ala Met His Pro Gln Val Asn Ile Tyr

130 135 140

Ser Val Thr Arg Lys Arg Tyr Ala His Leu Ser Ala Arg Pro Ala Asp

145 150 155 160

Glu Ile Ala Val Asp Arg Asp Val Pro Trp Gly Val Asp Ser Leu Ile

165 170 175

Thr Leu Ala Phe Gln Asp Gln Arg Tyr Ser Val Gln Thr Ala Asp His

180 185 190

Arg Phe Leu Arg His Asp Gly Arg Leu Val Ala Arg Pro Glu Pro Ala

195 200 205

Thr Gly Tyr Thr Leu Glu Phe Arg Ser Gly Lys Val Ala Phe Arg Asp

210 215 220

Cys Glu Gly Arg Tyr Leu Ala Pro Ser Gly Pro Ser Gly Thr Leu Lys

225 230 235 240

Ala Gly Lys Ala Thr Lys Val Gly Lys Asp Glu Leu Phe Ala Leu Glu

245 250 255

Gln Ser Cys Ala Gln Val Val Leu Gln Ala Ala Asn Glu Arg Asn Val

260 265 270

Ser Thr Arg Gln Gly Met Asp Leu Ser Ala Asn Gln Asp Glu Glu Thr

275 280 285

Asp Gln Glu Thr Phe Gln Leu Glu Ile Asp Arg Asp Thr Lys Lys Cys

290 295 300

Ala Phe Arg Thr His His Thr Gly Lys Tyr Trp Thr Leu Thr Ala Thr Gly

305 310 315 320

Gly Val Gln Ser Thr Ala Ser Ser Lys Asn Ala Ser Cys Tyr Phe Asp

325 330 335

Ile Glu Trp Arg Asp Arg Arg Ile Thr Leu Arg Ala Ser Asn Gly Lys

340 345 350

Phe Val Thr Ser Lys Lys Asn Gly Gln Leu Ala Ala Ser Val Glu Thr

355 360 365

Ala Gly Asp Ser Glu Leu Phe Leu Met Lys Leu Ile Asn Arg Pro Ile

370 375 380

Ile Val Phe Arg Gly Glu His Gly Phe Ile Gly Cys Arg Lys Val Thr

385 390 395 400

Gly Thr Leu Asp Ala Asn Arg Ser Ser Tyr Asp Val Phe Gln Leu Glu

405 410 415

Phe Asn Asp Gly Ala Tyr Asn Ile Lys Asp Ser Thr Gly Lys Tyr Trp

420 425 430

Thr Val Gly Ser Asp Ser Ala Val Thr Ser Ser Gly Asp Thr Pro Val

435 440 445

Asp Phe Phe Phe Glu Phe Cys Asp Tyr Asn Lys Val Ala Ile Lys Val

450 455 460

Gly Gly Arg Tyr Leu Lys Gly Asp His Ala Gly Val Leu Lys Ala Ser

465 470 475 480

Ala Glu Thr Val Asp Pro Ala Ser Leu Trp Glu Tyr

485 490

<210>59

<211>317

<212>PRT

<213> Human (Homo sapiens)

<220>

<221> Apolipoprotein-E precursor

<222>(1)..(317)

<223> August 29, 2003 Registration number: P02649

<400>59

Met Lys Val Leu Trp Ala Ala Leu Leu Val Thr Phe Leu Ala Gly Cys

1 5 10 15

Gln Ala Lys Val Glu Gln Ala Val Glu Thr Glu Pro Glu Pro Glu Leu

20 25 30

Arg Gln Gln Thr Glu Trp Gln Ser Gly Gln Arg Trp Glu Leu Ala Leu

35 40 45

Gly Arg Phe Trp Asp Tyr Leu Arg Trp Val Gln Thr Leu Ser Glu Gln

50 55 60

Val Gln Glu Glu Leu Leu Ser Ser Ser Gln Val Thr Gln Glu Leu Arg Ala

65 70 75 80

Leu Met Asp Glu Thr Met Lys Glu Leu Lys Ala Tyr Lys Ser Glu Leu

85 90 95

Glu Glu Gln Leu Thr Pro Val Ala Glu Glu Thr Arg Ala Arg Leu Ser

100 105 110

Lys Glu Leu Gln Ala Ala Gln Ala Arg Leu Gly Ala Asp Met Glu Asp

115 120 125

Val Cys Gly Arg Leu Val Gln Tyr Arg Gly Glu Val Gln Ala Met Leu

130 135 140

Gly Gln Ser Thr Glu Glu Leu Arg Val Arg Leu Ala Ser His Leu Arg

145 150 155 160

Lys Leu Arg Lys Arg Leu Leu Arg Asp Ala Asp Asp Leu Gln Lys Arg

165 170 175

Leu Ala Val Tyr Gln Ala Gly Ala Arg Glu Gly Ala Glu Arg Gly Leu

180 185 190

Ser Ala Ile Arg Glu Arg Leu Gly Pro Leu Val Glu Gln Gly Arg Val

195 200 205

Arg Ala Ala Thr Val Gly Ser Leu Ala Gly Gln Pro Leu Gln Glu Arg

210 215 220

Ala Gln Ala Trp Gly Glu Arg Leu Arg Ala Arg Met Glu Glu Met Gly

225 230 235 240

Ser Arg Thr Arg Asp Arg Leu Asp Glu Val Lys Glu Gln Val Ala Glu

245 250 255

Val Arg Ala Lys Leu Glu Glu Gln Ala Gln Gln Ile Arg Leu Gln Ala

260 265 270

Glu Ala Phe Gln Ala Arg Leu Lys Ser Trp Phe Glu Pro Leu Val Glu

275 280 285

Asp Met Gln Arg Gln Trp Ala Gly Leu Val Glu Lys Val Gln Ala Ala

290 295 300

Val Gly Thr Ser Ala Ala Pro Val Pro Ser Asp Asn His

305 310 315

<210>60

<211>838

<212>PRT

<213> Human (Homo sapiens)

<220>

<221> Hypothetical 88.6kDa protein

<222>(1)..(838)

<223> August 29, 2003 Registration number: Q96C61

<400>60

Met Pro Ser Gly Lys Val Ala Gln Pro Thr Ile Thr Asp Asn Lys Asp

1 5 10 15

Gly Thr Val Thr Val Arg Tyr Ala Pro Ser Glu Ala Gly Leu His Glu

20 25 30

Met Asp Ile Arg Tyr Asp Asn Met His Ile Pro Gly Ser Pro Leu Gln

35 40 45

Phe Tyr Val Asp Tyr Val Asn Cys Gly His Val Thr Ala Tyr Gly Pro

50 55 60

Gly Leu Thr His Gly Val Val Asn Lys Pro Ala Thr Phe Thr Val Asn

65 70 75 80

Thr Lys Asp Ala Gly Glu Gly Gly Leu Ser Leu Ala Ile Glu Gly Pro

85 90 95

Ser Lys Ala Glu Ile Ser Cys Thr Asp Asn Gln Asp Gly Thr Cys Ser

100 105 110

Val Ser Tyr Leu Pro Val Leu Pro Gly Asp Tyr Ser Ile Leu Val Lys

115 120 125

Tyr Asn Glu Gln His Val Pro Gly Ser Pro Phe Thr Ala Arg Val Thr

130 135 140

Gly Asp Asp Ser Met Arg Met Ser His Leu Lys Val Gly Ser Ala Ala

145 150 155 160

Asp Ile Pro Ile Asn Ile Ser Glu Thr Asp Leu Ser Leu Leu Thr Ala

165 170 175

Thr Val Val Pro Pro Ser Gly Arg Glu Glu Pro Cys Leu Leu Lys Arg

180 185 190

Leu Arg Asn Gly His Val Gly Ile Ser Phe Val Pro Lys Glu Thr Gly

195 200 205

Glu His Leu Val His Val Lys Lys Asn Gly Gln His Val Ala Ser Ser

210 215 220

Pro Ile Pro Val Val Ile Ser Gln Ser Glu Ile Gly Asp Ala Ser Arg

225 230 235 240

Val Arg Val Ser Gly Gln Gly Leu His Glu Gly His Thr Phe Glu Pro

245 250 255

Ala Glu Phe Ile Ile Asp Thr Arg Asp Ala Gly Tyr Gly Gly Leu Ser

260 265 270

Leu Ser Ile Glu Gly Pro Ser Lys Val Asp Ile Asn Thr Glu Asp Leu

275 280 285

Glu Asp Gly Thr Cys Arg Val Thr Tyr Cys Pro Thr Glu Pro Gly Asn

290 295 300

Tyr Ile Ile Asn Ile Lys Phe Ala Asp Gln His Val Pro Gly Ser Pro

305 310 315 320

Phe Ser Val Lys Val Thr Gly Glu Gly Arg Val Lys Glu Ser Ile Thr

325 330 335

Arg Arg Arg Arg Ala Pro Ser Val Ala Asn Val Gly Ser His Cys Asp

340 345 350

Leu Ser Leu Lys Ile Pro Glu Ile Ser Ile Gln Asp Met Thr Ala Gln

355 360 365

Val Thr Ser Pro Ser Gly Lys Thr His Glu Ala Glu Ile Val Glu Gly

370 375 380

Glu Asn His Thr Tyr Cys Ile Arg Phe Val Pro Ala Glu Met Gly Thr

385 390 395 400

His Thr Val Ser Val Lys Tyr Lys Gly Gln His Val Pro Gly Ser Pro

405 410 415

Phe Gln Phe Thr Val Gly Pro Leu Gly Glu Gly Gly Ala His Lys Val

420 425 430

Arg Ala Gly Gly Pro Gly Leu Glu Arg Ala Glu Ala Gly Val Pro Ala

435 440 445

Glu Phe Ser Ile Trp Thr Arg Glu Ala Gly Ala Gly Gly Leu Ala Ile

450 455 460

Ala Val Glu Gly Pro Ser Lys Ala Glu Ile Ser Phe Glu Asp Arg Lys

465 470 475 480

Asp Gly Ser Cys Gly Val Ala Tyr Val Val Gln Glu Pro Gly Asp Tyr

485 490 495

Glu Val Ser Val Lys Phe Asn Glu Glu His Ile Pro Asp Ser Pro Phe

500 505 5l0

Val Val Pro Val Ala Ser Pro Ser Gly Asp Ala Arg Arg Leu Thr Val

515 520 525

Ser Ser Leu Gln Glu Ser Gly Leu Lys Val Asn Gln Pro Ala Ser Phe

530 535 540

Ala Val Ser Leu Asn Gly Ala Lys Gly Ala Ile Asp Ala Lys Val His

545 550 555 560

Ser Pro Ser Gly Ala Leu Glu Glu Cys Tyr Val Thr Glu Ile Asp Gln

565 570 575

Asp Lys Tyr Ala Val Arg Phe Ile Pro Arg Glu Asn Gly Val Tyr Leu

580 585 590

Ile Asp Val Lys Phe Asn Gly Thr His Ile Pro Gly Ser Pro Phe Lys

595 600 605

Ile Arg Val Gly Glu Pro Gly His Gly Gly Asp Pro Gly Leu Val Ser

610 615 620

Ala Tyr Gly Ala Gly Leu Glu Gly Gly Val Thr Gly Asn Pro Ala Glu

625 630 635 640

Phe Val Val Asn Thr Ser Asn Ala Gly Ala Gly Ala Leu Ser Val Thr

645 650 655

Ile Asp Gly Pro Ser Lys Val Lys Met Asp Cys Gln Glu Cys Pro Glu

660 665 670

Gly Tyr Arg Val Thr Tyr Thr Pro Met Ala Pro Gly Ser Tyr Leu Ile

675 680 685

Ser Ile Lys Tyr Gly Gly Pro Tyr His Ile Gly Gly Ser Pro Phe Lys

690 695 700

Ala Lys Val Thr Gly Pro Arg Leu Val Ser Asn His Ser Leu His Glu

705 710 715 720

Thr Ser Ser Val Phe Val Asp Ser Leu Thr Lys Ala Thr Cys Ala Pro

725 730 735

Gln His Gly Ala Pro Gly Pro Gly Pro Ala Asp Ala Ser Lys Val Val

740 745 750

Ala Lys Gly Leu Gly Leu Ser Lys Ala Tyr Val Gly Gln Lys Ser Ser

755 760 765

Phe Thr Val Asp Cys Ser Lys Ala Gly Asn Asn Met Leu Leu Val Gly

770 775 780

Val His Gly Pro Arg Thr Pro Cys Glu Glu Ile Leu Val Lys His Val

785 790 795 800

Gly Ser Arg Leu Tyr Ser Val Ser Tyr Leu Leu Lys Asp Lys Gly Glu

805 810 815

Tyr Thr Leu Val Val Lys Trp Gly Asp Glu His Ile Pro Gly Ser Pro

820 825 830

Tyr Arg Val Val Val Pro

835

<210>61

<211>433

<212>PRT

<213> Human (Homo sapiens)

<220>

<221> Human alpha-enolase

<222>(1)..(433)

<223> August 29, 2003 Registration number: P06733

<400>61

Ser Ile Leu Lys Ile His Ala Arg Glu Ile Phe Asp Ser Arg Gly Asn

1 5 10 15

Pro Thr Val Glu Val Asp Leu Phe Thr Ser Lys Gly Leu Phe Arg Ala

20 25 30

Ala Val Pro Ser Gly Ala Ser Thr Gly Ile Tyr Glu Ala Leu Glu Leu

35 40 45

Arg Asp Asn Asp Lys Thr Arg Tyr Met Gly Lys Gly Val Ser Lys Ala

50 55 60

Val Glu His Ile Asn Lys Thr Ile Ala Pro Ala Leu Val Ser Lys Lys

65 70 75 80

Leu Asn Val Thr Glu Gln Glu Lys Ile Asp Lys Leu Met Ile Glu Met

85 90 95

Asp Gly Thr Glu Asn Lys Ser Lys Phe Gly Ala Asn Ala Ile Leu Gly

100 105 110

Val Ser Leu Ala Val Cys Lys Ala Gly Ala Val Glu Lys Gly Val Pro

115 120 125

Leu Tyr Arg His Ile Ala Asp Leu Ala Gly Asn Ser Glu Val Ile Leu

130 135 140

Pro Val Pro Ala Phe Asn Val Ile Asn Gly Gly Ser His Ala Gly Asn

145 150 155 160

Lys Leu Ala Met Gln Glu Phe Met Ile Leu Pro Val Gly Ala Ala Asn

165 170 175

Phe Arg Glu Ala Met Arg Ile Gly Ala Glu Val Tyr His Asn Leu Lys

180 185 190

Asn Val Ile Lys Glu Lys Tyr Gly Lys Asp Ala Thr Asn Val Gly Asp

195 200 205

Glu Gly Gly Phe Ala Pro Asn Ile Leu Glu Asn Lys Glu Gly Leu Glu

210 215 220

Leu Leu Lys Thr Ala Ile Gly Lys Ala Gly Tyr Thr Asp Lys Val Val

225 230 235 240

Ile Gly Met Asp Val Ala Ala Ser Glu Phe Phe Arg Ser Gly Lys Tyr

245 250 255

Asp Leu Asp Phe Lys Ser Pro Asp Asp Pro Ser Arg Tyr Ile Ser Pro

260 265 270

Asp Gln Leu Ala Asp Leu Tyr Lys Ser Phe Ile Lys Asp Tyr Pro Val

275 280 285

Val Ser Ile Glu Asp Pro Phe Asp Gln Asp Asp Trp Gly Ala Trp Gln

290 295 300

Lys Phe Thr Ala Ser Ala Gly Ile Gln Val Val Gly Asp Asp Leu Thr

305 310 315 320

Val Thr Asn Pro Lys Arg Ile Ala Lys Ala Val Asn Glu Lys Ser Cys

325 330 335

Asn Cys Leu Leu Leu Lys Val Asn Gln Ile Gly Ser Val Thr Glu Ser

340 345 350

Leu Gln Ala Cys Lys Leu Ala Gln Ala Asn Gly Trp Gly Val Met Val

355 360 365

Ser His Arg Ser Gly Glu Thr Glu Asp Thr Phe Ile Ala Asp Leu Val

370 375 380

Val Gly Leu Cys Thr Gly Gln Ile Lys Thr Gly Ala Pro Cys Arg Ser

385 390 395 400

Glu Arg Leu Ala Lys Tyr Asn Gln Leu Leu Arg Ile Glu Glu Glu Leu

405 410 415

Gly Ser Lys Ala Lys Phe Ala Gly Arg Asn Phe Arg Asn Pro Leu Ala

420 425 430

Lys

<210>62

<211>471

<212>PRT

<213> Human (Homo sapiens)

<220>

<221> Tryptophan tRNA synthetase

<222>(1)..(471)

<223> August 29, 2003 Registration number: P23381

<400>62

Met Pro Asn Ser Glu Pro Ala Ser Leu Leu Glu Leu Phe Asn Ser Ile

1 5 10 15

Ala Thr Gln Gly Glu Leu Val Arg Ser Leu Lys Ala Gly Asn Ala Ser

20 25 30

Lys Asp Glu Ile Asp Ser Ala Val Lys Met Leu Val Ser Leu Lys Met

35 40 45

Ser Tyr Lys Ala Ala Ala Gly Glu Asp Tyr Lys Ala Asp Cys Pro Pro

50 55 60

Gly Asn Pro Ala Pro Thr Ser Asn His Gly Pro Asp Ala Thr Glu Ala

65 70 75 80

Glu Glu Asp Phe Val Asp Pro Trp Thr Val Gln Thr Ser Ser Ala Lys

85 90 95

Gly Ile Asp Tyr Asp Lys Leu Ile Val Arg Phe Gly Ser Ser Lys Ile

100 105 110

Asp Lys Glu Leu Ile Asn Arg Ile Glu Arg Ala Thr Gly Gln Arg Pro

115 120 125

His His Phe Leu Arg Arg Gly Ile Phe Phe Ser His Arg Asp Met Asn

130 135 140

Gln Val Leu Asp Ala Tyr Glu Asn Lys Lys Pro Phe Tyr Leu Tyr Thr

145 150 155 160

Gly Arg Gly Pro Ser Ser Glu Ala Met His Val Gly His Leu Ile Pro

165 170 175

Phe Ile Phe Thr Lys Trp Leu Gln Asp Val Phe Asn Val Pro Leu Val

180 185 190

Ile Gln Met Thr Asp Asp Glu Lys Tyr Leu Trp Lys Asp Leu Thr Leu

195 200 205

Asp Gln Ala Tyr Ser Tyr Ala Val Glu Asn Ala Lys Asp Ile Ile Ala

210 215 220

Cys Gly Phe Asp Ile Asn Lys Thr Phe Ile Phe Ser Asp Leu Asp Tyr

225 230 235 240

Met Gly Met Ser Ser Ser Gly Phe Tyr Lys Asn Val Val Lys Ile Gln Lys

245 250 255

His Val Thr Phe Asn Gln Val Lys Gly Ile Phe Gly Phe Thr Asp Ser

260 265 270

Asp Cys Ile Gly Lys Ile Ser Phe Pro Ala Ile Gln Ala Ala Pro Ser

275 280 285

Phe Ser Asn Ser Phe Pro Gln Ile Phe Arg Asp Arg Thr Asp Ile Gln

290 295 300

Cys Leu Ile Pro Cys Ala Ile Asp Gln Asp Pro Tyr Phe Arg Met Thr

305 310 315 320

Arg Asp Val Ala Pro Arg Ile Gly Tyr Pro Lys Pro Ala Leu Leu His

325 330 335

Ser Thr Phe Phe Pro Ala Leu Gln Gly Ala Gln Thr Lys Met Ser Ala

340 345 350

Ser Asp Pro Asn Ser Ser Ile Phe Leu Thr Asp Thr Ala Lys Gln Ile

355 360 365

Lys Thr Lys Val Asn Lys His Ala Phe Ser Gly Gly Arg Asp Thr Ile

370 375 380

Glu Glu His Arg Gln Phe Gly Gly Asn Cys Asp Val Asp Val Ser Phe

385 390 395 400

Met Tyr Leu Thr Phe Phe Leu Glu Asp Asp Asp Lys Leu Glu Gln Ile

405 410 415

Arg Lys Asp Tyr Thr Ser Gly Ala Met Leu Thr Gly Glu Leu Lys Lys

420 425 430

Ala Leu Ile Glu Val Leu Gln Pro Leu Ile Ala Glu His Gln Ala Arg

435 440 445

Arg Lys Glu Val Thr Asp Glu Ile Val Lys Glu Phe Met Thr Pro Arg

450 455 460

Lys Leu Ser Phe Asp Phe Gln

465 470

<210>63

<211>106

<212>PRT

<213> Human (Homo sapiens)

<220>

<221> Ig kappa chain C domain I

<222>(1)..(106)

<223> August 29, 2003 Registration number: P01834

<400>63

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln

1 5 10 15

Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Asn Phe Tyr

20 25 30

Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser

35 40 45

Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr

50 55 60

Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys

65 70 75 80

His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro

85 90 95

Val Thr Lys Ser Phe Asn Arg Gly Glu Cys

100 105

<210>64

<211>758

<212>PRT

<213> Human (Homo sapiens)

<220>

<221>Mitofilin

<222>(1)..(758)

<223> August 29, 2003 Registration number: Q16891

<400>64

Met Leu Arg Ala Cys Gln Leu Ser Gly Val Thr Ala Ala Ala Gln Ser

1 5 10 15

Cys Leu Cys Gly Lys Phe Val Leu Arg Pro Leu Arg Pro Cys Arg Arg

20 25 30

Tyr Ser Thr Ser Gly Ser Ser Ser Gly Leu Thr Thr Gly Lys Ile Ala Gly

35 40 45

Ala Gly Leu Leu Phe Val Gly Gly Gly Ile Gly Gly Thr Ile Leu Tyr

50 55 60

Ala Lys Trp Asp Ser His Phe Arg Glu Ser Val Glu Lys Thr Ile Pro

65 70 75 80

Tyr Ser Asp Lys Leu Phe Glu Met Val Leu Gly Pro Ala Ala Tyr Asn

85 90 95

Val Pro Leu Pro Lys Lys Ser Ile Gln Ser Gly Pro Leu Lys Ile Ser

100 105 110

Ser Val Ser Glu Val Met Lys Glu Ser Lys Gln Pro Ala Ser Gln Leu

115 120 125

Gln Lys Gln Lys Gly Asp Thr Pro Ala Ser Ala Thr Ala Pro Thr Glu

130 135 140

Ala Ala Gln Ile Ile Ser Ala Ala Gly Asp Thr Leu Ser Val Pro Ala

145 150 155 160

Pro Ala Val Gln Pro Glu Glu Ser Leu Lys Thr Asp His Pro Glu Ile

165 170 175

Gly Glu Gly Lys Pro Thr Pro Ala Leu Ser Glu Glu Ala Ser Ser Ser

180 185 190

Ser Ile Arg Glu Arg Pro Pro Glu Glu Val Ala Ala Arg Leu Ala Gln

195 200 205

Gln Glu Lys Gln Glu Gln Val Lys Ile Glu Ser Leu Ala Lys Ser Leu

210 215 220

Glu Asp Ala Leu Arg Gln Thr Ala Ser Val Thr Leu Gln Ala Ile Ala

225 230 235 240

Ala Gln Asn Ala Ala Val Gln Ala Val Asn Ala His Ser Asn Ile Leu

245 250 255

Lys Ala Ala Met Asp Asn Ser Glu Ile Ala Gly Glu Lys Lys Ser Ala

260 265 270

Gln Trp Arg Thr Val Glu Gly Ala Leu Lys Glu Arg Arg Lys Ala Val

275 280 285

Asp Glu Ala Ala Asp Ala Leu Leu Lys Ala Lys Glu Glu Leu Glu Lys

290 295 300

Met Lys Ser Val Ile Glu Asn Ala Lys Lys Lys Glu Val Ala Gly Ala

305 310 315 320

Lys Pro His Ile Thr Ala Ala Glu Gly Lys Leu His Asn Met Ile Val

325 330 335

Asp Leu Asp Asn Val Val Lys Lys Val Gln Ala Ala Gln Ser Glu Ala

340 345 350

Lys Val Val Ser Gln Tyr His Glu Leu Val Val Gln Ala Arg Asp Asp

355 360 365

Phe Lys Arg Glu Leu Asp Ser Ile Thr Pro Glu Val Leu Pro Gly Trp

370 375 380

Lys Gly Met Ser Val Ser Asp Leu Ala Asp Lys Leu Ser Thr Asp Asp

385 390 395 400

Leu Asn Ser Leu Ile Ala His Ala His Arg Arg Ile Asp Gln Leu Asn

405 410 415

Arg Glu Leu Ala Glu Gln Lys Ala Thr Glu Lys Gln His Ile Thr Leu

420 425 430

Ala Leu Glu Lys Gln Lys Leu Glu Glu Lys Arg Ala Phe Asp Ser Ala

435 440 445

Val Ala Lys Ala Leu Glu His His Arg Ser Glu Ile Gln Ala Glu Gln

450 455 460

Asp Arg Lys Ile Glu Glu Val Arg Asp Ala Met Glu Asn Glu Met Arg

465 470 475 480

Thr Gln Leu Arg Arg Gln Ala Ala Ala His Thr Asp His Leu Arg Asp

485 490 495

Val Leu Arg Val Gln Glu Gln Glu Leu Lys Ser Glu Phe Glu Gln Asn

500 505 510

Leu Ser Glu Lys Leu Ser Glu Gln Glu Leu Gln Phe Arg Arg Leu Ser

515 520 525

Gln Glu Gln Val Asp Asn Phe Thr Leu Asp Ile Asn Thr Ala Tyr Ala

530 535 540

Arg Leu Arg Gly Ile Glu Gln Ala Val Gln Ser His Ala Val Ala Glu

545 550 555 560

Glu Glu Ala Arg Lys Ala His Gln Leu Trp Leu Ser Val Glu Ala Leu

565 570 575

Lys Tyr Ser Met Lys Thr Ser Ser Ala Glu Thr Pro Thr Ile Pro Leu

580 585 590

Gly Ser Ala Val Glu Ala Ile Lys Ala Asn Cys Ser Asp Asn Glu Phe

595 600 605

Thr Gln Ala Leu Thr Ala Ala Ile Pro Pro Glu Ser Leu Thr Arg Gly

610 615 620

Val Tyr Ser Glu Glu Thr Leu Arg Ala Arg Phe Tyr Ala Val Gln Lys

625 630 635 640

Leu Ala Arg Arg Val Ala Met Ile Asp Glu Thr Arg Asn Ser Leu Tyr

645 650 655

Gln Tyr Phe Leu Ser Tyr Leu Gln Ser Leu Leu Leu Phe Pro Pro Gln

660 665 670

Gln Leu Lys Pro Pro Pro Glu Leu Cys Pro Glu Asp Ile Asn Thr Phe

675 680 685

Lys Leu Leu Ser Tyr Ala Ser Tyr Cys Ile Glu His Gly Asp Leu Glu

690 695 700

Leu Ala Ala Lys Phe Val Asn Gln Leu Lys Gly Glu Ser Arg Arg Val

705 710 715 720

Ala Gln Asp Trp Leu Lys Glu Ala Arg Met Thr Leu Glu Thr Lys Gln

725 730 735

Ile Val Glu Ile Leu Thr Ala Tyr Ala Ser Ala Val Gly Ile Gly Thr

740 745 750

Thr Gln Val Gln Pro Glu

755

<210>65

<211>1410

<212>PRT

<213> Human (Homo sapiens)

<220>

<221> ribosome binding protein 1

<222>(1)..(1410)

<223> August 29, 2003 Registration number: 075300

<400>65

Met Asp Ile Tyr Asp Thr Gln Thr Leu Gly Val Val Val Phe Gly Gly

1 5 10 15

Phe Met Val Val Ser Ala Ile Gly Ile Phe Leu Val Ser Thr Phe Ser

20 25 30

Met Lys Glu Thr Ser Tyr Glu Glu Ala Leu Ala Asn Gln Arg Lys Glu

35 40 45

Met Ala Lys Thr His His Gln Lys Val Glu Lys Lys Lys Lys Glu Lys

50 55 60

Thr Val Glu Lys Lys Gly Lys Thr Lys Lys Lys Glu Glu Lys Pro Asn

65 70 75 80

Gly Lys Ile Pro Asp His Asp Pro Ala Pro Asn Val Thr Val Leu Leu

85 90 95

Arg Glu Pro Val Arg Ala Pro Ala Val Ala Val Ala Pro Thr Pro Val

100 105 110

Gln Pro Pro Ile Ile Val Ala Pro Val Ala Thr Val Pro Ala Met Pro

115 120 125

Gln Glu Lys Leu Ala Ser Ser Pro Lys Asp Lys Lys Lys Lys Glu Lys

130 135 140

Lys Val Ala Lys Val Glu Pro Ala Val Ser Ser Val Val Asn Ser Ile

145 150 155 160

Gln Val Leu Thr Ser Lys Ala Ala Ile Leu Glu Thr Ala Pro Lys Glu

165 170 175

Val Pro Met Val Val Val Pro Pro Val Gly Ala Lys Gly Asn Thr Pro

180 185 190

Ala Thr Gly Thr Thr Gln Gly Lys Lys Ala Glu Gly Thr Gln Asn Gln

195 200 205

Ser Lys Lys Ala Glu Gly Ala Pro Asn Gln Gly Arg Lys Ala Glu Gly

210 215 220

Thr Pro Asn Gln Gly Lys Lys Thr Glu Gly Thr Pro Asn Gln Gly Lys

225 230 235 240

Lys Ala Glu Gly Thr Pro Asn Gln Gly Lys Lys Ala Glu Gly Thr Pro

245 250 255

Asn Gln Gly Lys Lys Ala Glu Gly Ala Gln Asn Gln Gly Lys Lys Val

260 265 270

Asp Thr Thr Pro Asn Gln Gly Lys Lys Val Glu Gly Ala Pro Thr Gln

275 280 285

Gly Arg Lys Ala Glu Gly Ala Gln Asn Gln Ala Lys Lys Val Glu Gly

290 295 300

Ala Gln Asn Gln Gly Lys Lys Ala Glu Gly Ala Gln Asn Gln Gly Lys

305 310 315 320

Lys Gly Glu Gly Ala Gln Asn Gln Gly Lys Lys Ala Glu Gly Ala Gln

325 330 335

Asn Gln Gly Lys Lys Ala Glu Gly Ala Gln Asn Gln Gly Lys Lys Ala

340 345 350

Glu Gly Ala Gln Asn Gln Gly Lys Lys Ala Glu Gly Ala Gln Asn Gln

355 360 365

Gly Lys Lys Ala Glu Gly Ala Gln Asn Gln Gly Lys Lys Ser Glu Gly

370 375 380

Ala Gln Asn Gln Gly Lys Lys Val Glu Gly Ala Gln Asn Gln Gly Lys

385 390 395 400

Lys Ala Glu Gly Ala Gln Asn Gln Gly Lys Lys Ala Glu Gly Ala Gln

405 410 415

Asn Gln Gly Lys Lys Ala Glu Gly Ala Gln Asn Gln Gly Lys Lys Ala

420 425 430

Glu Gly Ala Gln Asn Gln Gly Lys Lys Ala Glu Gly Ala Gln Asn Gln

435 440 445

Gly Lys Lys Ala Glu Gly Ala Gln Asn Gln Gly Lys Lys Ala Glu Gly

450 455 460

Ala Gln Asn Gln Gly Lys Lys Val Glu Gly Ala Gln Asn Gln Gly Lys

465 470 475 480

Lys Ala Glu Gly Ala Gln Asn Gln Gly Lys Lys Ala Glu Gly Ala Gln

485 490 495

Asn Gln Gly Lys Lys Ala Glu Gly Ala Gln Asn Gln Gly Gln Lys Gly

500 505 510

Glu Gly Ala Gln Asn Gln Gly Lys Lys Thr Glu Gly Ala Gln Gly Lys

515 520 525

Lys Ala Glu Arg Ser Pro Asn Gln Gly Lys Lys Gly Glu Gly Ala Pro

530 535 540

Ile Gln Gly Lys Lys Ala Asp Ser Val Ala Asn Gln Gly Thr Lys Val

545 550 555 560

Glu Gly Ile Thr Asn Gln Gly Lys Lys Ala Glu Gly Ser Pro Ser Glu

565 570 575

Gly Lys Lys Ala Glu Gly Ser Pro Asn Gln Gly Lys Lys Ala Asp Ala

580 585 590

Ala Ala Asn Gln Gly Lys Lys Thr Glu Ser Ala Ser Val Gln Gly Arg

595 600 605

Asn Thr Asp Val Ala Gln Ser Pro Glu Ala Pro Lys Gln Glu Ala Pro

610 615 620

Ala Lys Lys Lys Ser Gly Ser Lys Lys Lys Gly Glu Pro Gly Pro Pro

625 630 635 640

Asp Ala Asp Gly Pro Leu Tyr Leu Pro Tyr Lys Thr Leu Val Ser Thr

645 650 655

Val Gly Ser Met Val Phe Asn Glu Gly Glu Ala Gln Arg Leu Ile Glu

660 665 670

Ile Leu Ser Glu Lys Ala Gly Ile Ile Gln Asp Thr Trp His Lys Ala

675 680 685

Thr Gln Lys Gly Asp Pro Val Ala Ile Leu Lys Arg Gln Leu Glu Glu

690 695 700

Lys Glu Lys Leu Leu Ala Thr Glu Gln Glu Asp Ala Ala Val Ala Lys

705 710 715 720

Ser Lys Leu Arg Glu Leu Asn Lys Glu Met Ala Ala Glu Lys Ala Lys

725 730 735

Ala Ala Ala Gly Glu Ala Lys Val Lys Lys Gln Leu Val Ala Arg Glu

740 745 750

Gln Glu Ile Thr Ala Val Gln Ala Arg Met Gln Ala Ser Tyr Arg Glu

755 760 765

His Val Lys Glu Val Gln Gln Leu Gln Gly Lys Ile Arg Thr Leu Gln

770 775 780

Glu Gln Leu Glu Asn Gly Pro Asn Thr Gln Leu Ala Arg Leu Gln Gln

785 790 795 800

Glu Asn Ser Ile Leu Arg Asp Ala Leu Asn Gln Ala Thr Ser Gln Val

805 810 815

Glu Ser Lys Gln Asn Ala Glu Leu Ala Lys Leu Arg Gln Glu Leu Ser

820 825 830

Lys Val Ser Lys Glu Leu Val Glu Lys Ser Glu Ala Val Arg Gln Asp

835 840 845

Glu Gln Gln Arg Lys Ala Leu Glu Ala Lys Ala Ala Ala Phe Glu Lys

850 855 860

Gln Val Leu Gln Leu Gln Ala Ser His Arg Glu Ser Glu Glu Ala Leu

865 870 875 880

Gln Lys Arg Leu Asp Glu Val Ser Arg Glu Leu Cys His Thr Gln Ser

885 890 895

Ser His Ala Ser Leu Arg Ala Asp Ala Glu Lys Ala Gln Glu Gln Gln

900 905 910

Gln Gln Met Ala Glu Leu His Ser Lys Leu Gln Ser Ser Glu Ala Glu

915 920 925

Val Arg Ser Lys Cys Glu Glu Leu Ser Gly Leu His Gly Gln Leu Gln

930 935 940

Glu Ala Arg Ala Glu Asn Ser Gln Leu Thr Glu Arg Ile Arg Ser Ile

945 950 955 960

Glu Ala Leu Leu Glu Ala Gly Gln Ala Arg Asp Ala Gln Asp Val Gln

965 970 975

Ala Ser Gln Ala Glu Ala Asp Gln Gln Gln Thr Arg Leu Lys Glu Leu

980 985 990

Glu Ser Gln Val Ser Gly Leu Glu Lys Glu Ala Ile Glu Leu Arg Glu

995 1000 1005

Ala Val Glu Gln Gln Lys Val Lys Asn Asn Asp Leu Arg Glu Lys

1010 1015 1020

Asn Trp Lys Ala Met Glu Ala Leu Ala Thr Ala Glu Gln Ala Cys

1025 1030 1035

Lys Glu Lys Leu Leu Ser Leu Thr Gln Ala Lys Glu Glu Ser Glu

1040 1045 1050

Lys Gln Leu Cys Leu Ile Glu Ala Gln Thr Met Glu Ala Leu Leu

1055 1060 1065

Ala Leu Leu Pro Glu Leu Ser Val Leu Ala Gln Gln Asn Tyr Thr

1070 1075 1080

Glu Trp Leu Gln Asp Leu Lys Glu Lys Gly Pro Thr Leu Leu Lys

1085 1090 1095

His Pro Pro Ala Pro Ala Glu Pro Ser Ser Asp Leu Ala Ser Lys

1100 1105 1110

Leu Arg Glu Ala Glu Glu Thr Gln Ser Thr Leu Gln Ala Glu Cys

1115 1120 1125

Asp Gln Tyr Arg Ser Ile Leu Ala Glu Thr Glu Gly Met Leu Arg

1130 1135 1140

Asp Leu Gln Lys Ser Val Glu Glu Glu Glu Gln Val Trp Arg Ala

1145 1150 1155

Lys Val Gly Ala Ala Glu Glu Glu Leu Gln Lys Ser Arg Val Thr

1160 1165 1170

Val Lys His Leu Glu Glu Ile Val Glu Lys Leu Lys Gly Glu Leu

1175 1180 1185

Glu Ser Ser Asp Gln Val Arg Glu His Thr Ser His Leu Glu Ala

1190 1195 1200

Glu Leu Glu Lys His Met Ala Ala Ala Ser Ala Glu Cys Gln Asn

1205 1210 1215

Tyr Ala Lys Glu Val Ala Gly Leu Arg Gln Leu Leu Leu Glu Ser

1220 1225 1230

Gln Ser Gln Leu Asp Ala Ala Lys Ser Glu Ala Gln Lys Gln Ser

1235 1240 1245

Asp Glu Leu Ala Leu Val Arg Gln Gln Leu Ser Glu Met Lys Ser

1250 1255 1260

His Val Glu Asp Gly Asp Ile Ala Gly Ala Pro Ala Ser Ser Pro

1265 1270 1275

Glu Ala Pro Pro Ala Glu Gln Asp Pro Val Gln Leu Lys Thr Gln

1280 1285 1290

Leu Glu Trp Thr Glu Ala Ile Leu Glu Asp Glu Gln Thr Gln Arg

1295 1300 1305

Gln Lys Leu Thr Ala Glu Phe Glu Glu Ala Gln Thr Ser Ala Cys

1310 1315 1320

Arg Leu Gln Glu Glu Leu Glu Lys Leu Arg Thr Ala Gly Pro Leu

1325 1330 1335

Glu Ser Ser Glu Thr Glu Glu Ala Ser Gln Leu Lys Glu Arg Leu

1340 1345 1350

Glu Lys Glu Lys Lys Leu Thr Ser Asp Leu Gly Arg Ala Ala Thr

1355 1360 1365

Arg Leu Gln Glu Leu Leu Lys Thr Thr Gln Glu Gln Leu Ala Arg

1370 1375 1380

Glu Lys Asp Thr Val Lys Lys Leu Gln Glu Gln Leu Glu Lys Ala

1385 1390 1395

Glu Asp Gly Ser Ser Ser Ser Lys Glu Gly Thr Ser Val

1400 1405 1410

<210>66

<211>453

<212>PRT

<213> Human (Homo sapiens)

<220>

<221> Fibrinogen gamma-chain precursor

<222>(1)..(453)

<223> August 29, 2003 Registration number: P02679

<400>66

Met Ser Trp Ser Leu His Pro Arg Asn Leu Ile Leu Tyr Phe Tyr Ala

1 5 10 15

Leu Leu Phe Leu Ser Ser Thr Cys Val Ala Tyr Val Ala Thr Arg Asp

20 25 30

Asn Cys Cys Ile Leu Asp Glu Arg Phe Gly Ser Tyr Cys Pro Thr Thr

35 40 45

Cys Gly Ile Ala Asp Phe Leu Ser Thr Tyr Gln Thr Lys Val Asp Lys

50 55 60

Asp Leu Gln Ser Leu Glu Asp Ile Leu His Gln Val Glu Asn Lys Thr

65 70 75 80

Ser Glu Val Lys Gln Leu Ile Lys Ala Ile Gln Leu Thr Tyr Asn Pro

85 90 95

Asp Glu Ser Ser Lys Pro Asn Met Ile Asp Ala Ala Thr Leu Lys Ser

100 105 110

Arg Lys Met Leu Glu Glu Ile Met Lys Tyr Glu Ala Ser Ile Leu Thr

115 120 125

His Asp Ser Ser Ile Arg Tyr Leu Gln Glu Ile Tyr Asn Ser Asn Asn

130 135 140

Gln Lys Ile Val Asn Leu Lys Glu Lys Val Ala Gln Leu Glu Ala Gln

145 150 155 160

Cys Gln Glu Pro Cys Lys Asp Thr Val Gln Ile His Asp Ile Thr Gly

165 170 175

Lys Asp Cys Gln Asp Ile Ala Asn Lys Gly Ala Lys Gln Ser Gly Leu

180 185 190

Tyr Phe Ile Lys Pro Leu Lys Ala Asn Gln Gln Phe Leu Val Tyr Cys

195 200 205

Glu Ile Asp Gly Ser Gly Asn Gly Trp Thr Val Phe Gln Lys Arg Leu

210 215 220

Asp Gly Ser Val Asp Phe Lys Lys Asn Trp Ile Gln Tyr Lys Glu Gly

225 230 235 240

Phe Gly His Leu Ser Pro Thr Gly Thr Thr Glu Phe Trp Leu Gly Asn

245 250 255

Glu Lys Ile His Leu Ile Ser Thr Gln Ser Ala Ile Pro Tyr Ala Leu

260 265 270

Arg Val Glu Leu Glu Asp Trp Asn Gly Arg Thr Ser Thr Ala Asp Tyr

275 280 285

Ala Met Phe Lys Val Gly Pro Glu Ala Asp Lys Tyr Arg Leu Thr Tyr

290 295 300

Ala Tyr Phe Ala Gly Gly Asp Ala Gly Asp Ala Phe Asp Gly Phe Asp

305 310 315 320

Phe Gly Asp Asp Pro Ser Asp Lys Phe Phe Thr Ser His Asn Gly Met

325 330 335

Gln Phe Ser Thr Trp Asp Asn Asp Asn Asp Lys Phe Glu Gly Asn Cys

340 345 350

Ala Glu Gln Asp Gly Ser Gly Trp Trp Met Asn Lys Cys His Ala Gly

355 360 365

His Leu Asn Gly Val Tyr Tyr Gln Gly Gly Thr Tyr Ser Lys Ala Ser

370 375 380

Thr Pro Asn Gly Tyr Asp Asn Gly Ile Ile Trp Ala Thr Trp Lys Thr

385 390 395 400

Arg Trp Tyr Ser Met Lys Lys Thr Thr Met Lys Ile Ile Pro Phe Asn

405 410 415

Arg Leu Thr Ile Gly Glu Gly Gln Gln His His Leu Gly Gly Ala Lys

420 425 430

Gln Val Arg Pro Glu His Pro Ala Glu Thr Glu Tyr Asp Ser Leu Tyr

435 440 445

Pro Glu Asp Asp Leu

450

<210>67

<211>622

<212>PRT

<213> Human (Homo sapiens)

<220>

<221> Prothrombin precursor

<222>(1)..(622)

<223> August 29, 2003 Registration number: P00734

<400>67

Met Ala His Val Arg Gly Leu Gln Leu Pro Gly Cys Leu Ala Leu Ala

1 5 10 15

Ala Leu Cys Ser Leu Val His Ser Gln His Val Phe Leu Ala Pro Gln

20 25 30

Gln Ala Arg Ser Leu Leu Gln Arg Val Arg Arg Ala Asn Thr Phe Leu

35 40 45

Glu Glu Val Arg Lys Gly Asn Leu Glu Arg Glu Cys Val Glu Glu Thr

50 55 60

Cys Ser Tyr Glu Glu Ala Phe Glu Ala Leu Glu Ser Ser Thr Ala Thr

65 70 75 80

Asp Val Phe Trp Ala Lys Tyr Thr Ala Cys Glu Thr Ala Arg Thr Pro

85 90 95

Arg Asp Lys Leu Ala Ala Cys Leu Glu Gly Asn Cys Ala Glu Gly Leu

100 105 110

Gly Thr Asn Tyr Arg Gly His Val Asn Ile Thr Arg Ser Gly Ile Glu

115 120 125

Cys Gln Leu Trp Arg Ser Arg Tyr Pro His Lys Pro Glu Ile Asn Ser

130 135 140

Thr Thr His Pro Gly Ala Asp Leu Gln Glu Asn Phe Cys Arg Asn Pro

145 150 155 160

Asp Ser Ser Thr Thr Gly Pro Trp Cys Tyr Thr Thr Asp Pro Thr Val

165 170 175

Arg Arg Gln Glu Cys Ser Ile Pro Val Cys Gly Gln Asp Gln Val Thr

180 185 190

Val Ala Met Thr Pro Arg Ser Glu Gly Ser Ser Val Asn Leu Ser Pro

195 200 205

Pro Leu Glu Gln Cys Val Pro Asp Arg Gly Gln Gln Tyr Gln Gly Arg

210 215 220

Leu Ala Val Thr Thr His Gly Leu Pro Cys Leu Ala Trp Ala Ser Ala

225 230 235 240

Gln Ala Lys Ala Leu Ser Lys His Gln Asp Phe Asn Ser Ala Val Gln

245 250 255

Leu Val Glu Asn Phe Cys Arg Asn Pro Asp Gly Asp Glu Glu Gly Val

260 265 270

Trp Cys Tyr Val Ala Gly Lys Pro Gly Asp Phe Gly Tyr Cys Asp Leu

275 280 285

Asn Tyr Cys Glu Glu Ala Val Glu Glu Glu Thr Gly Asp Gly Leu Asp

290 295 300

Glu Asp Ser Asp Arg Ala Ile Glu Gly Arg Thr Ala Thr Ser Glu Tyr

305 310 315 320

Gln Thr Phe Phe Asn Pro Arg Thr Phe Gly Ser Gly Glu Ala Asp Cys

325 330 335

Gly Leu Arg Pro Leu Phe Glu Lys Lys Ser Leu Glu Asp Lys Thr Glu

340 345 350

Arg Glu Leu Leu Glu Ser Tyr Ile Asp Gly Arg Ile Val Glu Gly Ser

355 360 365

Asp Ala Glu Ile Gly Met Ser Pro Trp Gln Val Met Leu Phe Arg Lys

370 375 380

Ser Pro Gln Glu Leu Leu Cys Gly Ala Ser Leu Ile Ser Asp Arg Trp

385 390 395 400

Val Leu Thr Ala Ala His Cys Leu Leu Tyr Pro Pro Trp Asp Lys Asn

405 410 415

Phe Thr Glu Asn Asp Leu Leu Val Arg Ile Gly Lys His Ser Arg Thr

420 425 430

Arg Tyr Glu Arg Asn Ile Glu Lys Ile Ser Met Leu Glu Lys Ile Tyr

435 440 445

Ile His Pro Arg Tyr Asn Trp Arg Glu Asn Leu Asp Arg Asp Ile Ala

450 455 460

Leu Met Lys Leu Lys Lys Pro Val Ala Phe Ser Asp Tyr Ile His Pro

465 470 475 480

Val Cys Leu Pro Asp Arg Glu Thr Ala Ala Ser Leu Leu Gln Ala Gly

485 490 495

Tyr Lys Gly Arg Val Thr Gly Trp Gly Asn Leu Lys Glu Thr Trp Thr

500 505 510

Ala Asn Val Gly Lys Gly Gln Pro Ser Val Leu Gln Val Val Asn Leu

515 520 525

Pro Ile Val Glu Arg Pro Val Cys Lys Asp Ser Thr Arg Ile Arg Ile

530 535 540

Thr Asp Asn Met Phe Cys Ala Gly Tyr Lys Pro Asp Glu Gly Lys Arg

545 550 555 560

Gly Asp Ala Cys Glu Gly Asp Ser Gly Gly Pro Phe Val Met Lys Ser

565 570 575

Pro Phe Asn Asn Arg Trp Tyr Gln Met Gly Ile Val Ser Trp Gly Glu

580 585 590

Gly Cys Asp Arg Asp Gly Lys Tyr Gly Phe Tyr Thr His Val Phe Arg

595 600 605

Leu Lys Lys Trp Ile Gln Lys Val Ile Asp Gln Phe Gly Glu

610 615 620

<210>68

<211>530

<212>PRT

<213> Human (Homo sapiens)

<220>

<221> pyruvate kinase

<222>(1)..(530)

<223> August 29, 2003 Registration number: P14618

<400>68

Ser Lys Pro His Ser Glu Ala Gly Thr Ala Phe Ile Gln Thr Gln Gln

1 5 10 15

Leu His Ala Ala Met Ala Asp Thr Phe Leu Glu His Met Cys Arg Leu

20 25 30

Asp Ile Asp Ser Pro Pro Ile Thr Ala Arg Asn Thr Gly Ile Ile Cys

35 40 45

Thr Ile Gly Pro Ala Ser Arg Ser Val Glu Thr Leu Lys Glu Met Ile

50 55 60

Lys Ser Gly Met Asn Val Ala Arg Leu Asn Phe Ser His Gly Thr His

65 70 75 80

Glu Tyr His Ala Glu Thr Ile Lys Asn Val Arg Thr Ala Thr Glu Ser

85 90 95

Phe Ala Ser Asp Pro Ile Leu Tyr Arg Pro Val Ala Val Ala Leu Asp

100 105 110

Thr Lys Gly Pro Glu Ile Arg Thr Gly Leu Ile Lys Gly Ser Gly Thr

115 120 125

Ala Glu Val Glu Leu Lys Lys Gly Ala Thr Leu Lys Ile Thr Leu Asp

130 135 140

Asn Ala Tyr Met Glu Lys Cys Asp Glu Asn Ile Leu Trp Leu Asp Tyr

145 150 155 160

Lys Asn Ile Cys Lys Val Val Glu Val Gly Ser Lys Ile Tyr Val Asp

165 170 175

Asp Gly Leu Ile Ser Leu Gln Val Lys Gln Lys Gly Ala Asp Phe Leu

180 185 190

Val Thr Glu Val Glu Asn Gly Gly Ser Leu Gly Ser Lys Lys Gly Val

195 200 205

Asn Leu Pro Gly Ala Ala Val Asp Leu Pro Ala Val Ser Glu Lys Asp

210 215 220

Ile Gln Asp Leu Lys Phe Gly Val Glu Gln Asp Val Asp Met Val Phe

225 230 235 240

Ala Ser Phe Ile Arg Lys Ala Ser Asp Val His Glu Val Arg Lys Val

245 250 255

Leu Gly Glu Lys Gly Lys Asn Ile Lys Ile Ile Ser Lys Ile Glu Asn

260 265 270

His Glu Gly Val Arg Arg Phe Asp Glu Ile Leu Glu Ala Ser Asp Gly

275 280 285

Ile Met Val Ala Arg Gly Asp Leu Gly Ile Glu Ile Pro Ala Glu Lys

290 295 300

Val Phe Leu Ala Gln Lys Met Met Ile Gly Arg Cys Asn Arg Ala Gly

305 310 315 320

Lys Pro Val Ile Cys Ala Thr Gln Met Leu Glu Ser Met Ile Lys Lys

325 330 335

Pro Arg Pro Thr Arg Ala Glu Gly Ser Asp Val Ala Asn Ala Val Leu

340 345 350

Asp Gly Ala Asp Cys Ile Met Leu Ser Gly Glu Thr Ala Lys Gly Asp

355 360 365

Tyr Pro Leu Glu Ala Val Arg Met Gln His Leu Ile Ala Arg Glu Ala

370 375 380

Glu Ala Ala Ile Tyr His Leu Gln Leu Phe Glu Glu Leu Arg Arg Leu

385 390 395 400

Ala Pro Ile Thr Ser Asp Pro Thr Glu Ala Thr Ala Val Gly Ala Val

405 410 415

Glu Ala Ser Phe Lys Cys Cys Ser Gly Ala Ile Ile Val Leu Thr Lys

420 425 430

Ser Gly Arg Ser Ala His Gln Val Ala Arg Tyr Arg Pro Arg Ala Pro

435 440 445

Ile Ile Ala Val Thr Arg Asn Pro Gln Thr Ala Arg Gln Ala His Leu

450 455 460

Tyr Arg Gly Ile Phe Pro Val Leu Cys Lys Asp Pro Val Gln Glu Ala

465 470 475 480

Trp Ala Glu Asp Val Asp Leu Arg Val Asn Phe Ala Met Asn Val Gly

485 490 495

Lys Ala Arg Gly Phe Phe Lys Lys Gly Asp Val Val Ile Val Leu Thr

500 505 510

Gly Trp Arg Pro Gly Ser Gly Phe Thr Asn Thr Met Arg Val Val Pro

515 520 525

Val Pro

530

<2l0>69

<211>328

<212>PRT

<213> Human (Homo sapiens)

<220>

<221> reticulon-calcin3 precursor

<222>(1)..(328)

<223> August 29, 2003 Registration number: Q96D15

<400>69

Met Met Trp Arg Pro Ser Val Leu Leu Leu Leu Leu Leu Leu Arg His

1 5 10 15

Gly Ala Gln Gly Lys Pro Ser Pro Asp Ala Gly Pro His Gly Gln Gly

20 25 30

Arg Val His Gln Ala Ala Pro Leu Ser Asp Ala Pro His Asp Asp Ala

35 40 45

His Gly Asn Phe Gln Tyr Asp His Glu Ala Phe Leu Gly Arg Glu Val

50 55 60

Ala Lys Glu Phe Asp Gln Leu Thr Pro Glu Glu Ser Gln Ala Arg Leu

65 70 75 80

Gly Arg Ile Val Asp Arg Met Asp Arg Ala Gly Asp Gly Asp Gly Trp

85 90 95

Val Ser Leu Ala Glu Leu Arg Ala Trp Ile Ala His Thr Gln Gln Arg

100 105 110

His Ile Arg Asp Ser Val Ser Ala Ala Trp Asp Thr Tyr Asp Thr Asp

115 120 125

Arg Asp Gly Arg Val Gly Trp Glu Glu Leu Arg Asn Ala Thr Tyr Gly

130 135 140

His Tyr Ala Pro Gly Glu Glu Phe His Asp Val Glu Asp Ala Glu Thr

145 150 155 160

Tyr Lys Lys Met Leu Ala Arg Asp Glu Arg Arg Phe Arg Val Ala Asp

165 170 175

Gln Asp Gly Asp Ser Met Ala Thr Arg Glu Glu Leu Thr Ala Phe Leu

180 185 190

His Pro Glu Glu Phe Pro His Met Arg Asp Ile Val Ile Ala Glu Thr

195 200 205

Leu Glu Asp Leu Asp Arg Asn Lys Asp Gly Tyr Val Gln Val Glu Glu

210 215 220

Tyr Ile Ala Asp Leu Tyr Ser Ala Glu Pro Gly Glu Glu Glu Pro Ala

225 230 235 240

Trp Val Gln Thr Glu Arg Gln Gln Phe Arg Asp Phe Arg Asp Leu Asn

245 250 255

Lys Asp Gly His Leu Asp Gly Ser Glu Val Gly His Trp Val Leu Pro

260 265 270

Pro Ala Gln Asp Gln Pro Leu Val Glu Ala Asn His Leu Leu His Glu

275 280 285

Ser Asp Thr Asp Lys Asp Gly Arg Leu Ser Lys Ala Glu Ile Leu Gly

290 295 300

Asn Trp Asn Met Phe Val Gly Ser Gln Ala Thr Asn Tyr Gly Glu Asp

305 310 315 320

Leu Thr Arg His His Asp Glu Leu

325

<210>70

<211>469

<212>PRT

<213> Human (Homo sapiens)

<220>

<221> Desmin

<222>(1)..(469)

<223> August 29, 2003 Registration number: P17661

<400>70

Ser Gln Ala Tyr Ser Ser Ser Ser Gln Arg Val Ser Ser Tyr Arg Arg Thr

1 5 10 15

Phe Gly Gly Ala Pro Gly Phe Pro Leu Gly Ser Pro Leu Ser Ser Pro

20 25 30

Val Phe Pro Arg Ala Gly Phe Gly Ser Lys Gly Ser Ser Ser Ser Val

35 40 45

Thr Ser Arg Val Tyr Gln Val Ser Arg Thr Ser Gly Gly Ala Gly Gly

50 55 60

Leu Gly Ser Leu Arg Ala Ser Arg Leu Gly Thr Thr Arg Thr Pro Ser

65 70 75 80

Ser Tyr Gly Ala Gly Glu Leu Leu Asp Phe Ser Leu Ala Asp Ala Val

85 90 95

Asn Gln Glu Phe Leu Thr Thr Arg Thr Asn Glu Lys Val Glu Leu Gln

100 105 110

Glu Leu Asn Asp Arg Phe Ala Asn Tyr Ile Glu Lys Val Arg Phe Leu

115 120 125

Glu Gln Gln Asn Ala Ala Leu Ala Ala Glu Val Asn Arg Leu Lys Gly

130 135 140

Arg Glu Pro Thr Arg Val Ala Glu Leu Tyr Glu Glu Glu Leu Arg Glu

145 150 155 160

Leu Arg Arg Gln Val Glu Val Leu Thr Asn Gln Arg Ala Arg Val Asp

165 170 175

Val Glu Arg Asp Asn Leu Leu Asp Asp Leu Gln Arg Leu Lys Ala Lys

180 185 190

Leu Gln Glu Glu Ile Gln Leu Lys Glu Glu Ala Glu Asn Asn Leu Ala

195 200 205

Ala Phe Arg Ala Asp Val Asp Ala Ala Thr Leu Ala Arg Ile Asp Leu

210 215 220

Glu Arg Arg Ile Glu Ser Leu Asn Glu Glu Ile Ala Phe Leu Lys Lys

225 230 235 240

Val His Glu Glu Glu Ile Arg Glu Leu Gln Ala Gln Leu Gln Glu Gln

245 250 255

Gln Val Gln Val Glu Met Asp Met Ser Lys Pro Asp Leu Thr Ala Ala

260 265 270

Leu Arg Asp Ile Arg Ala Gln Tyr Glu Thr Ile Ala Ala Lys Asn Ile

275 280 285

Ser Glu Ala Glu Glu Trp Tyr Lys Ser Lys Val Ser Asp Leu Thr Gln

290 295 300

Ala Ala Asn Lys Asn Asn Asp Ala Leu Arg Gln Ala Lys Gln Glu Met

305 310 315 320

Met Glu Tyr Arg His Gln Ile Gln Ser Tyr Thr Cys Glu Ile Asp Ala

325 330 335

Leu Lys Gly Thr Asn Asp Ser Leu Met Arg Gln Met Arg Glu Leu Glu

340 345 350

Asp Arg Phe Ala Ser Glu Ala Ser Gly Tyr Gln Asp Asn Ile Ala Arg

355 360 365

Leu Glu Glu Glu Ile Arg His Leu Lys Asp Glu Met Ala Arg His Leu

370 375 380

Arg Glu Tyr Gln Asp Leu Leu Asn Val Lys Met Ala Leu Asp Val Glu

385 390 395 400

Ile Ala Thr Tyr Arg Lys Leu Leu Glu Gly Glu Glu Ser Arg Ile Asn

405 410 415

Leu Pro Ile Gln Thr Tyr Ser Ala Leu Asn Phe Arg Glu Thr Ser Pro

420 425 430

Glu Gln Arg Gly Ser Glu Val His Thr Lys Lys Thr Val Met Ile Lys

435 440 445

Thr Ile Glu Thr Arg Asp Gly Glu Val Val Ser Glu Ala Thr Gln Gln

450 455 460

Gln His Glu Val Leu

465

<210>71

<211>417

<212>PRT

<213> Human (Homo sapiens)

<220>

<221> Carboxypeptidase B precursor

<222>(1)..(417)

<223> August 29, 2003 Registration number: P15086

<400>71

Met Leu Ala Leu Leu Val Leu Val Thr Val Ala Leu Ala Ser Ala His

1 5 10 15

His Gly Gly Glu His Phe Glu Gly Glu Lys Val Phe Arg Val Asn Val

20 25 30

Glu Asp Glu Asn His Ile Asn Ile Ile Arg Glu Leu Ala Ser Thr Thr

35 40 45

Gln Ile Asp Phe Trp Lys Pro Asp Ser Val Thr Gln Ile Lys Pro His

50 55 60

Ser Thr Val Asp Phe Arg Val Lys Ala Glu Asp Thr Val Thr Val Glu

65 70 75 80

Asn Val Leu Lys Gln Asn Glu Leu Gln Tyr Lys Val Leu Ile Ser Asn

85 90 95

Leu Arg Asn Val Val Glu Ala Gln Phe Asp Ser Arg Val Arg Ala Thr

100 105 110

Gly His Ser Tyr Glu Lys Tyr Asn Lys Trp Glu Thr Ile Glu Ala Trp

115 120 125

Thr Gln Gln Val Ala Thr Glu Asn Pro Ala Leu Ile Ser Arg Ser Val

130 135 140

Ile Gly Thr Thr Phe Glu Gly Arg Ala Ile Tyr Leu Leu Lys Val Gly

145 150 155 160

Lys Ala Gly Gln Asn Lys Pro Ala Ile Phe Met Asp Cys Gly Phe His

165 170 175

Ala Arg Glu Trp Ile Ser Pro Ala Phe Cys Gln Trp Phe Val Arg Glu

180 185 190

Ala Val Arg Thr Tyr Gly Arg Glu Ile Gln Val Thr Glu Leu Leu Asp

195 200 205

Lys Leu Asp Phe Tyr Val Leu Pro Val Leu Asn Ile Asp Gly Tyr Ile

210 215 220

Tyr Thr Trp Thr Lys Ser Arg Phe Trp Arg Lys Thr Arg Ser Thr His

225 230 235 240

Thr Gly Ser Ser Cys Ile Gly Thr Asp Pro Asn Arg Asn Phe Asp Ala

245 250 255

Gly Trp Cys Glu Ile Gly Ala Ser Arg Asn Pro Cys Asp Glu Thr Tyr

260 265 270

Cys Gly Pro Ala Ala Glu Ser Glu Lys Glu Thr Lys Ala Leu Ala Asp

275 280 285

Phe Ile Arg Asn Lys Leu Ser Ser Ile Lys Ala Tyr Leu Thr Ile His

290 295 300

Ser Tyr Ser Gln Met Met Ile Tyr Pro Tyr Ser Tyr Ala Tyr Lys Leu

305 310 315 320

Gly Glu Asn Asn Ala Glu Leu Asn Ala Leu Ala Lys Ala Thr Val Lys

325 330 335

Glu Leu Ala Ser Leu His Gly Thr Lys Tyr Thr Tyr Gly Pro Gly Ala

340 345 350

Thr Thr Ile Tyr Pro Ala Ala Gly Gly Ser Asp Asp Trp Ala Tyr Asp

355 360 365

Gln Gly Ile Arg Tyr Ser Phe Thr Phe Glu Leu Arg Asp Thr Gly Arg

370 375 380

Tyr Gly Phe Leu Leu Pro Glu Ser Gln Ile Arg Ala Thr Cys Glu Glu

385 390 395 400

Thr Phe Leu Ala Ile Lys Tyr Val Ala Ser Tyr Val Leu Glu His Leu

405 410 415

Tyr

<210>72

<211>419

<212>PRT

<213> Human (Homo sapiens)

<220>

<221> carboxypeptidase A1 precursor

<222>(1)..(419)

<223> August 29, 2003 Registration number: P15085

<400>72

Met Arg Gly Leu Leu Val Leu Ser Val Leu Leu Gly Ala Val Phe Gly

1 5 10 15

Lys Glu Asp Phe Val Gly His Gln Val Leu Arg Ile Ser Val Ala Asp

20 25 30

Glu Ala Gln Val Gln Lys Val Lys Glu Leu Glu Asp Leu Glu His Leu

35 40 45

Gln Leu Asp Phe Trp Arg Gly Pro Ala His Pro Gly Ser Pro Ile Asp

50 55 60

Val Arg Val Pro Phe Pro Ser Ile Gln Ala Val Lys Ile Phe Leu Glu

65 70 75 80

Ser His Gly Ile Ser Tyr Glu Thr Met Ile Glu Asp Val Gln Ser Leu

85 90 95

Leu Asp Glu Glu Gln Glu Gln Met Phe Ala Phe Arg Ser Arg Ala Arg

100 105 110

Ser Thr Asp Thr Phe Asn Tyr Ala Thr Tyr His Thr Leu Glu Glu Ile

115 120 125

Tyr Asp Phe Leu Asp Leu Leu Val Ala Glu Asn Pro His Leu Val Ser

130 135 140

Lys Ile Gln Ile Gly Asn Thr Tyr Glu Gly Arg Pro Ile Tyr Val Leu

145 150 155 160

Lys Phe Ser Thr Gly Gly Ser Lys Arg Pro Ala Ile Trp Ile Asp Thr

165 170 175

Gly Ile His Ser Arg Glu Trp Val Thr Gln Ala Ser Gly Val Trp Phe

180 185 190

Ala Lys Lys Ile Thr Gln Asp Tyr Gly Gln Asp Ala Ala Phe Thr Ala

195 200 205

Ile Leu Asp Thr Leu Asp Ile Phe Leu Glu Ile Val Thr Asn Pro Asp

210 215 220

Gly Phe Ala Phe Thr His Ser Thr Asn Arg Met Trp Arg Lys Thr Arg

225 230 235 240

Ser His Thr Ala Gly Ser Leu Cys Ile Gly Val Asp Pro Asn Arg Asn

245 250 255

Trp Asp Ala Gly Phe Gly Leu Ser Gly Ala Ser Ser Asn Pro Cys Ser

260 265 270

Glu Thr Tyr His Gly Lys Phe Ala Asn Ser Glu Val Glu Val Lys Ser

275 280 285

Ile Val Asp Phe Val Lys Asp His Gly Asn Ile Lys Ala Phe Ile Ser

290 295 300

Ile His Ser Tyr Ser Gln Leu Leu Met Tyr Pro Tyr Gly Tyr Lys Thr

305 310 315 320

Glu Pro Val Pro Asp Gln Asp Glu Leu Asp Gln Leu Ser Lys Ala Ala

325 330 335

Val Thr Ala Leu Ala Ser Leu Tyr Gly Thr Lys Phe Asn Tyr Gly Ser

340 345 350

Ile Ile Lys Ala Ile Tyr Gln Ala Ser Gly Ser Thr Ile Asp Trp Thr

355 360 365

Tyr Ser Gln Gly Ile Lys Tyr Ser Phe Thr Phe Glu Leu Arg Asp Thr

370 375 380

Gly Arg Tyr Gly Phe Leu Leu Pro Ala Ser Gln Ile Ile Pro Thr Ala

385 390 395 400

Lys Glu Thr Trp Leu Ala Leu Leu Thr Ile Met Glu His Thr Leu Asn

405 410 415

His Pro Tyr

<210>73

<211>418

<212>PRT

<213> Human (Homo sapiens)

<220>

<221> Colligin 2

<222>(1)..(418)

<223> August 29, 2003 Registration number: P50454

<400>73

Met Arg Ser Leu Leu Leu Leu Ser Ala Phe Cys Leu Leu Glu Ala Ala

1 5 10 15

Leu Ala Ala Glu Val Lys Lys Pro Ala Ala Ala Ala Ala Pro Gly Thr

20 25 30

Ala Glu Lys Leu Ser Pro Lys Ala Ala Thr Leu Ala Glu Arg Ser Ala

35 40 45

Gly Leu Ala Phe Ser Leu Tyr Gln Ala Met Ala Lys Asp Gln Ala Val

50 55 60

Glu Asn Ile Leu Val Ser Pro Val Val Val Ala Ser Ser Leu Gly Leu

65 70 75 80

Val Ser Leu Gly Gly Lys Ala Thr Thr Ala Ser Gln Ala Lys Ala Val

85 90 95

Leu Ser Ala Glu Gln Leu Arg Asp Glu Glu Val His Ala Gly Leu Gly

100 105 110

Glu Leu Leu Arg Ser Leu Ser Ser Asn Ser Thr Ala Arg Asn Val Thr Trp

115 120 125

Lys Leu Gly Ser Arg Leu Tyr Gly Pro Ser Ser Val Ser Phe Ala Asp

130 135 140

Asp Phe Val Arg Ser Ser Lys Gln His Tyr Asn Cys Glu His Ser Lys

145 150 155 160

Ile Asn Phe Arg Asp Lys Arg Ser Ala Leu Gln Ser Ile Asn Glu Trp

165 170 175

Ala Ala Gln Thr Thr Asp Gly Lys Leu Pro Glu Val Thr Lys Asp Val

180 185 190

Glu Arg Thr Asp Gly Ala Leu Leu Val Asn Ala Met Phe Phe Lys Pro

195 200 205

His Trp Asp Glu Lys Phe His His Lys Met Val Asp Asn Arg Gly Phe

210 215 220

Met Val Thr Arg Ser Tyr Thr Val Gly Val Met Met Met His Arg Thr

225 230 235 240

Gly Leu Tyr Asn Tyr Tyr Asp Asp Glu Lys Glu Lys Leu Gln Ile Val

245 250 255

Glu Met Pro Leu Ala His Lys Leu Ser Ser Leu Ile Ile Leu Met Pro

260 265 270

His His Val Glu Pro Leu Glu Arg Leu Glu Lys Leu Leu Thr Lys Glu

275 280 285

Gln Leu Lys Ile Trp Met Gly Lys Met Gln Lys Lys Ala Val Ala Ile

290 295 300

Ser Leu Pro Lys Gly Val Val Glu Val Thr His Asp Leu Gln Lys His

305 310 315 320

Leu Ala Gly Leu Gly Leu Thr Glu Ala Ile Asp Lys Asn Lys Ala Asp

325 330 335

Leu Ser Arg Met Ser Gly Lys Lys Asp Leu Tyr Leu Ala Ser Val Phe

340 345 350

His Ala Thr Ala Phe Glu Leu Asp Thr Asp Gly Asn Pro Phe Asp Gln

355 360 365

Asp Ile Tyr Gly Arg Glu Glu Leu Arg Ser Pro Lys Leu Phe Tyr Ala

370 375 380

Asp His Pro Phe Ile Phe Leu Val Arg Asp Thr Gln Ser Gly Ser Leu

385 390 395 400

Leu Phe Ile Gly Arg Leu Val Arg Pro Lys Gly Asp Lys Met Arg Asp

405 410 415

Glu Leu

<210>74

<211>263

<212>PRT

<213> Human (Homo sapiens)

<220>

<221> Chymotrypsinogen B precursor

<222>(1)..(263)

<223> August 29, 2003 Registration number: P17538

<400>74

Met Ala Phe Leu Trp Leu Leu Ser Cys Trp Ala Leu Leu Gly Thr Thr

1 5 10 15

Phe Gly Cys Gly Val Pro Ala Ile His Pro Val Leu Ser Gly Leu Ser

20 25 30

Arg Ile Val Asn Gly Glu Asp Ala Val Pro Gly Ser Trp Pro Trp Gln

35 40 45

Val Ser Leu Gln Asp Lys Thr Gly Phe His Phe Cys Gly Gly Ser Leu

50 55 60

Ile Ser Glu Asp Trp Val Val Thr Ala Ala His Cys Gly Val Arg Thr

65 70 75 80

Ser Asp Val Val Val Ala Gly Glu Phe Asp Gln Gly Ser Asp Glu Glu

85 90 95

Asn Ile Gln Val Leu Lys Ile Ala Lys Val Phe Lys Asn Pro Lys Phe

100 105 110

Ser Ile Leu Thr Val Asn Asn Asp Ile Thr Leu Leu Lys Leu Ala Thr

115 120 125

Pro Ala Arg Phe Ser Gln Thr Val Ser Ala Val Cys Leu Pro Ser Ala

130 135 140

Asp Asp Asp Phe Pro Ala Gly Thr Leu Cys Ala Thr Thr Gly Trp Gly

145 150 155 160

Lys Thr Lys Tyr Asn Ala Asn Lys Thr Pro Asp Lys Leu Gln Gln Ala

165 170 175

Ala Leu Pro Leu Leu Ser Asn Ala Glu Cys Lys Lys Ser Trp Gly Arg

180 185 190

Arg Ile Thr Asp Val Met Ile Cys Ala Gly Ala Ser Gly Val Ser Ser

195 200 205

Cys Met Gly Asp Ser Gly Gly Pro Leu Val Cys Gln Lys Asp Gly Ala

210 215 220

Trp Thr Leu Val Gly Ile Val Ser Trp Gly Ser Asp Thr Cys Ser Thr

225 230 235 240

Ser Ser Pro Gly Val Tyr Ala Arg Val Thr Lys Leu Ile Pro Trp Val

245 250 255

Gln Lys Ile Leu Ala Ala Asn

260

<210>75

<211>247

<212>PRT

<213> Human (Homo sapiens)

<220>

<221> Trypsin I precursor

<222>(1)..(247)

<223> August 29, 2003 Registration number: P07477

<400>75

Met Asn Pro Leu Leu Ile Leu Thr Phe Val Ala Ala Ala Leu Ala Ala

1 5 10 15

Pro Phe Asp Asp Asp Asp Lys Ile Val Gly Gly Tyr Asn Cys Glu Glu

20 25 30

Asn Ser Val Pro Tyr Gln Val Ser Leu Asn Ser Gly Tyr His Phe Cys

35 40 45

Gly Gly Ser Leu Ile Asn Glu Gln Trp Val Val Ser Ala Gly His Cys

50 55 60

Tyr Lys Ser Arg Ile Gln Val Arg Leu Gly Glu His Asn Ile Glu Val

65 70 75 80

Leu Glu Gly Asn Glu Gln Phe Ile Asn Ala Ala Lys Ile Ile Arg His

85 90 95

Pro Gln Tyr Asp Arg Lys Thr Leu Asn Asn Asp Ile Met Leu Ile Lys

100 105 110

Leu Ser Ser Arg Ala Val Ile Asn Ala Arg Val Ser ThrIle Ser Leu

115 120 125

Pro Thr Ala Pro Pro Ala Thr Gly Thr Lys Cys Leu Ile Ser Gly Trp

130 135 140

Gly Asn Thr Ala Ser Ser Gly Ala Asp Tyr Pro Asp Glu Leu Gln Cys

145 150 155 160

Leu Asp Ala Pro Val Leu Ser Gln Ala Lys Cys Glu Ala Ser Tyr Pro

165 170 175

Gly Lys Ile Thr Ser Asn Met Phe Cys Val Gly Phe Leu Glu Gly Gly

180 185 190

Lys Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro Val Val Cys Asn Gly

195 200 205

Gln Leu Gln Gly Val Val Ser Trp Gly Asp Gly Cys Ala Gln Lys Asn

210 215 220

Lys Pro Gly Val Tyr Thr Lys Val Tyr Asn Tyr Val Lys Trp Ile Lys

225 230 235 240

Asn Thr Ile Ala Ala Asn Ser

245

<210>76

<211>247

<212>PRT

<213> Human (Homo sapiens)

<220>

<221> Trypsin II precursor

<222>(1)..(247)

<223> August 29, 2003 Registration number: P07478

<400>76

Met Asn Leu Leu Leu Ile Leu Thr Phe Val Ala Ala Ala Val Ala Ala

1 5 10 15

Pro Phe Asp Asp Asp Asp Lys Ile Val Gly Gly Tyr Ile Cys Glu Glu

20 25 30

Asn Ser Val Pro Tyr Gln Val Ser Leu Asn Ser Gly Tyr His Phe Cys

35 40 45

Gly Gly Ser Leu Ile Ser Glu Gln Trp Val Val Ser Ala Gly His Cys

50 55 60

Tyr Lys Ser Arg Ile Gln Val Arg Leu Gly Glu His Asn Ile Glu Val

65 70 75 80

Leu Glu Gly Asn Glu Gln Phe Ile Asn Ala Ala Lys Ile Ile Arg His

85 90 95

Pro Lys Tyr Asn Ser Arg Thr Leu Asp Asn Asp Ile Leu Leu Ile Lys

100 105 110

Leu Ser Ser Pro Ala Val Ile Asn Ser Arg Val Ser Ala Ile Ser Leu

115 120 125

Pro Thr Ala Pro Pro Ala Ala Gly Thr Glu Ser Leu Ile Ser Gly Trp

130 135 140

Gly Asn Thr Leu Ser Ser Gly Ala Asp Tyr Pro Asp Glu Leu Gln Cys

145 150 155 160

Leu Asp Ala Pro Val Leu Ser Gln Ala Glu Cys Glu Ala Ser Tyr Pro

165 170 175

Gly Lys Ile Thr Asn Asn Met Phe Cys Val Gly Phe Leu Glu Gly Gly

180 185 190

Lys Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro Val Val Ser Asn Gly

195 200 205

Glu Leu Gln Gly Ile Val Ser Trp Gly Tyr Gly Cys Ala Gln Lys Asn

210 215 220

Arg Pro Gly Val Tyr Thr Lys Val Tyr Asn Tyr Val Asp Trp Ile Lys

225 230 235 240

Asp Thr Ile Ala Ala Asn Ser

245

<210>77

<211>379

<212>PRT

<213> Human (Homo sapiens)

<220>

<221> Leukocyte elastase inhibitor (LEI)

<222>(1)..(379)

<223> August 29, 2003 Registration Number: P30740

<400>77

Met Glu Gln Leu Ser Ser Ala Asn Thr Arg Phe Ala Leu Asp Leu Phe

1 5 10 15

Leu Ala Leu Ser Glu Asn Asn Pro Ala Gly Asn Ile Phe Ile Ser Pro

20 25 30

Phe Ser Ile Ser Ser Ser Ala Met Ala Met Val Phe Leu Gly Thr Arg Gly

35 40 45

Asn Thr Ala Ala Gln Leu Ser Lys Thr Phe His Phe Asn Thr Val Glu

50 55 60

Glu Val His Ser Arg Phe Gln Ser Leu Asn Ala Asp Ile Asn Lys Arg

65 70 75 80

Gly Ala Ser Tyr Ile Leu Lys Leu Ala Asn Arg Leu Tyr Gly Glu Lys

85 90 95

Thr Tyr Asn Phe Leu Pro Glu Phe Leu Val Ser Thr Gln Lys Thr Tyr

100 105 110

Gly Ala Asp Leu Ala Ser Val Asp Phe Gln His Ala Ser Glu Asp Ala

115 120 125

Arg Lys Thr Ile Asn Gln Trp Val Lys Gly Gln Thr Glu Gly Lys Ile

130 135 140

Pro Glu Leu Leu Ala Ser Gly Met Val Asp Asn Met Thr Lys Leu Val

145 150 155 160

Leu Val Asn Ala Ile Tyr Phe Lys Gly Asn Trp Lys Asp Lys Phe Met

165 170 175

Lys Glu Ala Thr Thr Asn Ala Pro Phe Arg Leu Asn Lys Lys Asp Arg

180 185 190

Lys Thr Val Lys Met Met Tyr Gln Lys Lys Lys Phe Ala Tyr Gly Tyr

195 200 205

Ile Glu Asp Leu Lys Cys Arg Val Leu Glu Leu Pro Tyr Gln Gly Glu

210 215 220

Glu Leu Ser Met Val Ile Leu Leu Pro Asp Asp Ile Glu Asp Glu Ser

225 230 235 240

Thr Gly Leu Lys Lys Ile Glu Glu Gln Leu Thr Leu Glu Lys Leu His

245 250 255

Glu Trp Thr Lys Pro Glu Asn Leu Asp Phe Ile Glu Val Asn Val Ser

260 265 270

Leu Pro Arg Phe Lys Leu Glu Glu Ser Tyr Thr Leu Asn Ser Asp Leu

275 280 285

Ala Arg Leu Gly Val Gln Asp Leu Phe Asn Ser Ser Lys Ala Asp Leu

290 295 300

Ser Gly Met Ser Gly Ala Arg Asp Ile Phe Ile Ser Lys Ile Val His

305 310 315 320

Lys Ser Phe Val Glu Val Asn Glu Glu Gly Thr Glu Ala Ala Ala Ala

325 330 335

Thr Ala Gly Ile Ala Thr Phe Cys Met Leu Met Pro Glu Glu Asn Phe

340 345 350

Thr Ala Asp His Pro Phe Leu Phe Phe Ile Arg His Asn Ser Ser Gly

355 360 365

Ser Ile Leu Phe Leu Gly Arg Phe Ser Ser Pro

370 375

<210>78

<211>573

<212>PRT

<213> Human (Homo sapiens)

<220>

<221> heat shock protein Hsp60

<222>(1)..(573)

<223> August 29, 2003 Registration number: P10809

<400>78

Met Leu Arg Leu Pro Thr Val Phe Arg Gln Met Arg Pro Val Ser Arg

1 5 10 15

Val Leu Ala Pro His Leu Thr Arg Ala Tyr Ala Lys Asp Val Lys Phe

20 25 30

Gly Ala Asp Ala Arg Ala Leu Met Leu Gln Gly Val Asp Leu Leu Ala

35 40 45

Asp Ala Val Ala Val Thr Met Gly Pro Lys Gly Arg Thr Val Ile Ile

50 55 60

Glu Gln Ser Trp Gly Ser Pro Lys Val Thr Lys Asp Gly Val Thr Val

65 70 75 80

Ala Lys Ser Ile Asp Leu Lys Asp Lys Tyr Lys Asn Ile Gly Ala Lys

85 90 95

Leu Val Gln Asp Val Ala Asn Asn Thr Asn Glu Glu Ala Gly Asp Gly

100 105 110

Thr Thr Thr Ala Thr Val Leu Ala Arg Ser Ile Ala Lys Glu Gly Phe

115 120 125

Glu Lys Ile Ser Lys Gly Ala Asn Pro Val Glu Ile Arg Arg Gly Val

130 135 140

Met Leu Ala Val Asp Ala Val Ile Ala Glu Leu Lys Lys Gln Ser Lys

145 150 155 160

Pro Val Thr Thr Pro Glu Glu Ile Ala Gln Val Ala Thr Ile Ser Ala

165 170 175

Asn Gly Asp Lys Glu Ile Gly Asn Ile Ile Ser Asp Ala Met Lys Lys

180 185 190

Val Gly Arg Lys Gly Val Ile Thr Val Lys Asp Gly Lys Thr Leu Asn

195 200 205

Asp Glu Leu Glu Ile Ile Glu Gly Met Lys Phe Asp Arg Gly Tyr Ile

210 215 220

Ser Pro Tyr Phe Ile Asn Thr Ser Lys Gly Gln Lys Cys Glu Phe Gln

225 230 235 240

Asp Ala Tyr Val Leu Leu Ser Glu Lys Lys Ile Ser Ser Ile Gln Ser

245 250 255

Ile Val Pro Ala Leu Glu Ile Ala Asn Ala His Arg Lys Pro Leu Val

260 265 270

Ile Ile Ala Glu Asp Val Asp Gly Glu Ala Leu Ser Thr Leu Val Leu

275 280 285

Asn Arg Leu Lys Val Gly Leu Gln Val Val Ala Val Lys Ala Pro Gly

290 295 300

Phe Gly Asp Asn Arg Lys Asn Gln Leu Lys Asp Met Ala Ile Ala Thr

305 310 315 320

Gly Gly Ala Val Phe Gly Glu Glu Gly Leu Thr Leu Asn Leu Glu Asp

325 330 335

Val Gln Pro His Asp Leu Gly Lys Val Gly Glu Val Ile Val Thr Lys

340 345 350

Asp Asp Ala Met Leu Leu Lys Gly Lys Gly Asp Lys Ala Gln Ile Glu

355 360 365

Lys Arg Ile Gln Glu Ile Ile Glu Gln Leu Asp Val Thr Thr Ser Glu

370 375 380

Tyr Glu Lys Glu Lys Leu Asn Glu Arg Leu Ala Lys Leu Ser Asp Gly

385 390 395 400

Val Ala Val Leu Lys Val Gly Gly Thr Ser Asp Val Glu Val Asn Glu

405 410 415

Lys Lys Asp Arg Val Thr Asp Ala Leu Asn Ala Thr Arg Ala Ala Val

420 425 430

Glu Glu Gly Ile Val Leu Gly Gly Gly Cys Ala Leu Leu Arg Cys Ile

435 440 445

Pro Ala Leu Asp Ser Leu Thr Pro Ala Asn Glu Asp Gln Lys Ile Gly

450 455 460

Ile Glu Ile Ile Lys Arg Thr Leu Lys Ile Pro Ala Met Thr Ile Ala

465 470 475 480

Lys Asn Ala Gly Val Glu Gly Ser Leu Ile Val Glu Lys Ile Met Gln

485 490 495

Ser Ser Ser Glu Val Gly Tyr Asp Ala Met Ala Gly Asp Phe Val Asn

500 505 510

Met Val Glu Lys Gly Ile Ile Asp Pro Thr Lys Val Val Arg Thr Ala

515 520 525

Leu Leu Asp Ala Ala Gly Val Ala Ser Leu Leu Thr Thr Ala Glu Val

530 535 540

Val Val Thr Glu Ile Pro Lys Glu Glu Lys Asp Pro Gly Met Gly Ala

545 550 555 560

Met Gly Gly Met Gly Gly Gly Met Gly Gly Gly Met Phe

565 570

<210>79

<211>803

<212>PRT

<213> Human (Homo sapiens)

<220>

<221> Grp94 protein precursor (GRP94)

<222>(1)..(803)

<223> August 29, 2003 Registration number: P14625

<400>79

Met Arg Ala Leu Trp Val Leu Gly Leu Cys Cys Val Leu Leu Thr Phe

1 5 10 15

Gly Ser Val Arg Ala Asp Asp Glu Val Asp Val Asp Gly Thr Val Glu

20 25 30

Glu Asp Leu Gly Lys Ser Arg Glu Gly Ser Arg Thr Asp Asp Glu Val

35 40 45

Val Gln Arg Glu Glu Glu Ala Ile Gln Leu Asp Gly Leu Asn Ala Ser

50 55 60

Gln Ile Arg Glu Leu Arg Glu Lys Ser Glu Lys Phe Ala Phe Gln Ala

65 70 75 80

Glu Val Asn Arg Met Met Lys Leu Ile Ile Asn Ser Leu Tyr Lys Asn

85 90 95

Lys Glu Ile Phe Leu Arg Glu Leu Ile Ser Asn Ala Ser Asp Ala Leu

100 105 110

Asp Lys Ile Arg Leu Ile Ser Leu Thr Asp Glu Asn Ala Leu Ser Gly

115 120 125

Asn Glu Glu Leu Thr Val Lys Ile Lys Cys Asp Lys Glu Lys Asn Leu

130 135 140

Leu His Val Thr Asp Thr Gly Val Gly Met Thr Arg Glu Glu Leu Val

145 150 155 160

Lys Asn Leu Gly Thr Ile Ala Lys Ser Gly Thr Ser Glu Phe Leu Asn

165 170 175

Lys Met Thr Glu Ala Gln Glu Asp Gly Gln Ser Thr Ser Glu Leu Ile

180 185 190

Gly Gln Phe Gly Val Gly Phe Tyr Ser Ala Phe Leu Val Ala Asp Lys

195 200 205

Val Ile Val Thr Ser Lys His Asn Asn Asp Thr Gln His Ile Trp Glu

210 215 220

Ser Asp Ser Asn Glu Phe Ser Val Ile Ala Asp Pro Arg Gly Asn Thr

225 230 235 240

Leu Gly Arg Gly Thr Thr Ile Thr Leu Val Leu Lys Glu Glu Ala Ser

245 250 255

Asp Tyr Leu Glu Leu Asp Thr Ile Lys Asn Leu Val Lys Lys Tyr Ser

260 265 270

Gln Phe Ile Asn Phe Pro Ile Tyr Val Trp Ser Ser Lys Thr Glu Thr

275 280 285

Val Glu Glu Pro Met Glu Glu Glu Glu Ala Ala Lys Glu Glu Lys Glu

290 295 300

Glu Ser Asp Asp Glu Ala Ala Val Glu Glu Glu Glu Glu Glu Lys Lys

305 310 315 320

Pro Lys Thr Lys Lys Val Glu Lys Thr Val Trp Asp Trp Glu Leu Met

325 330 335

Asn Asp Ile Lys Pro Ile Trp Gln Arg Pro Ser Lys Glu Val Glu Glu

340 345 350

Asp Glu Tyr Lys Ala Phe Tyr Lys Ser Phe Ser Lys Glu Ser Asp Asp

355 360 365

Pro Met Ala Tyr Ile His Phe Thr Ala Glu Gly Glu Val Thr Phe Lys

370 375 380

Ser Ile Leu Phe Val Pro Thr Ser Ala Pro Arg Gly Leu Phe Asp Glu

385 390 395 400

Tyr Gly Ser Lys Lys Ser Asp Tyr Ile Lys Leu Tyr Val Arg Arg Val

405 410 415

Phe Ile Thr Asp Asp Phe His Asp Met Met Pro Lys Tyr Leu Asn Phe

420 425 430

Val Lys Gly Val Val Asp Ser Asp Asp Leu Pro Leu Asn Val Ser Arg

435 440 445

Glu Thr Leu Gln Gln His Lys Leu Leu Lys Val Ile Arg Lys Lys Leu

450 455 460

Val Arg Lys Thr Leu Asp Met Ile Lys Lys Ile Ala Asp Asp Lys Tyr

465 470 475 480

Asn Asp Thr Phe Trp Lys Glu Phe Gly Thr Asn Ile Lys Leu Gly Val

485 490 495

Ile Glu Asp His Ser Asn Arg Thr Arg Leu Ala Lys Leu Leu Arg Phe

500 505 510

Gln Ser Ser His His Pro Thr Asp Ile Thr Ser Leu Asp Gln Tyr Val

515 520 525

Glu Arg Met Lys Glu Lys Gln Asp Lys Ile Tyr Phe Met Ala Gly Ser

530 535 540

Ser Arg Lys Glu Ala Glu Ser Ser Pro Phe Val Glu Arg Leu Leu Lys

545 550 555 560

Lys Gly Tyr Glu Val Ile Tyr Leu Thr Glu Pro Val Asp Glu Tyr Cys

565 570 575

Ile Gln Ala Leu Pro Glu Phe Asp Gly Lys Arg Phe Gln Asn Val Ala

580 585 590

Lys Glu Gly Val Lys Phe Asp Glu Ser Glu Lys Thr Lys Glu Ser Arg

595 600 605

Glu Ala Val Glu Lys Glu Phe Glu Pro Leu Leu Asn Trp Met Lys Asp

610 615 620

Lys Ala Leu Lys Asp Lys Ile Glu Lys Ala Val Val Ser Gln Arg Leu

625 630 635 640

Thr Glu Ser Pro Cys Ala Leu Val Ala Ser Gln Tyr Gly Trp Ser Gly

645 650 655

Asn Met Glu Arg Ile Met Lys Ala Gln Ala Tyr Gln Thr Gly Lys Asp

660 665 670

Ile Ser Thr Asn Tyr Tyr Ala Ser Gln Lys Lys Thr Phe Glu Ile Asn

675 680 685

Pro Arg His Pro Leu Ile Arg Asp Met Leu Arg Arg Ile Lys Glu Asp

690 695 700

Glu Asp Asp Lys Thr Val Leu Asp Leu Ala Val Val Leu Phe Glu Thr

705 710 715 720

Ala Thr Leu Arg Ser Gly Tyr Leu Leu Pro Asp Thr Lys Ala Tyr Gly

725 730 735

Asp Arg Ile Glu Arg Met Leu Arg Leu Ser Leu Asn Ile Asp Pro Asp

740 745 750

Ala Lys Val Glu Glu Glu Pro Glu Glu Glu Pro Glu Glu Thr Ala Glu

755 760 765

Asp Thr Thr Glu Asp Thr Glu Gln Asp Glu Asp Glu Glu Met Asp Val

770 775 780

Gly Thr Asp Glu Glu Glu Glu Thr Ala Lys Glu Ser Thr Ala Glu Lys

785 790 795 800

Asp Glu Leu

<210>80

<211>261

<212>PRT

<213> Human (Homo sapiens)

<220>

<221> Endoplasmic reticulum protein ERp29 precursor (ERp31) (ERp28)

<222>(1)..(261)

<223> August 29, 2003 Registration Number: P30040

<400>80

Met Ala Ala Ala Val Pro Arg Ala Ala Phe Leu Ser Pro Leu Leu Pro

1 5 10 15

Leu Leu Leu Gly Phe Leu Leu Leu Ser Ala Pro His Gly Gly Ser Gly

20 25 30

Leu His Thr Lys Gly Ala Leu Pro Leu Asp Thr Val Thr Phe Tyr Lys

35 40 45

Val Ile Pro Lys Ser Lys Phe Val Leu Val Lys Phe Asp Thr Gln Tyr

50 55 60

Pro Tyr Gly Glu Lys Gln Asp Glu Phe Lys Arg Leu Ala Glu Asn Ser

65 70 75 80

Ala Ser Ser Asp Asp Leu Leu Val Ala Glu Val Gly Ile Ser Asp Tyr

85 90 95

Gly Asp Lys Leu Asn Met Glu Leu Ser Glu Lys Tyr Lys Leu Asp Lys

100 105 110

Glu Ser Tyr Pro Val Phe Tyr Leu Phe Arg Asp Gly Asp Phe Glu Asn

115 120 125

Pro Val Pro Tyr Thr Gly Ala Val Lys Val Gly Ala Ile Gln Arg Trp

130 135 140

Leu Lys Gly Gln Gly Val Tyr Leu Gly Met Pro Gly Cys Leu Pro Val

145 150 155 160

Tyr Asp Ala Leu Ala Gly Glu Phe Ile Arg Ala Ser Gly Val Glu Ala

165 170 175

Arg Gln Ala Leu Leu Lys Gln Gly Gln Asp Asn Leu Ser Ser Val Lys

180 185 190

Glu Thr Gln Lys Lys Trp Ala Glu Gln Tyr Leu Lys Ile Met Gly Lys

195 200 205

Ile Leu Asp Gln Gly Glu Asp Phe Pro Ala Ser Glu Met Thr Arg Ile

210 215 220

Ala Arg Leu Ile Glu Lys Asn Lys Met Ser Asp Gly Lys Lys Glu Glu

225 230 235 240

Leu Gln Lys Ser Leu Asn Ile Leu Thr Ala Phe Gln Lys Lys Gly Ala

245 250 255

Glu Lys Glu Glu Leu

260

<210>81

<211>525

<212>PRT

<213> Human (Homo sapiens)

<220>

<221> Protein disulfide isomerase A2 precursor

<222>(1)..(525)

<223> August 29, 2003 Registration number: Q13087

<400>81

Met Ser Arg Gln Leu Leu Pro Val Leu Leu Leu Leu Leu Leu Arg Ala

1 5 10 15

Ser Cys Pro Trp Gly Gln Glu Gln Gly Ala Arg Ser Pro Ser Glu Glu

20 25 30

Pro Pro Glu Glu Glu Ile Pro Lys Glu Asp Gly Ile Leu Val Leu Ser

35 40 45

Arg His Thr Leu Gly Leu Ala Leu Arg Glu His Pro Ala Leu Leu Val

50 55 60

Glu Phe Tyr Ala Pro Trp Cys Gly His Cys Gln Ala Leu Ala Pro Glu

65 70 75 80

Tyr Ser Lys Ala Ala Ala Val Leu Ala Ala Glu Ser Met Val Val Thr

85 90 95

Leu Ala Lys Val Asp Gly Pro Ala Gln Arg Glu Leu Ala Glu Glu Phe

100 105 110

Gly Val Thr Glu Tyr Pro Thr Leu Lys Phe Phe Arg Asn Gly Asn Arg

115 120 125

Thr His Pro Glu Glu Tyr Thr Gly Pro Arg Asp Ala Glu Gly Ile Ala

130 135 140

Glu Trp Leu Arg Arg Arg Val Gly Pro Ser Ala Met Arg Leu Glu Asp

145 150 155 160

Glu Ala Ala Ala Gln Ala Leu Ile Gly Gly Arg Asp Leu Val Val Ile

165 170 175

Gly Phe Phe Gln Asp Leu Gln Asp Glu Asp Val Ala Thr Phe Leu Ala

180 185 190

Leu Ala Gln Asp Ala Leu Asp Met Thr Phe Gly Leu Thr Asp Arg Pro

195 200 205

Arg Leu Phe Gln Gln Phe Gly Leu Thr Lys Asp Thr Val Val Leu Phe

210 215 220

Lys Lys Phe Asp Glu Gly Arg Ala Asp Phe Pro Val Asp Glu Glu Leu

225 230 235 240

Gly Leu Asp Leu Gly Asp Leu Ser Arg Phe Leu Val Thr His Ser Met

245 250 255

Arg Leu Val Thr Glu Phe Asn Ser Gln Thr Ser Ala Lys Ile Phe Ala

260 265 270

Ala Arg Ile Leu Asn His Leu Leu Leu Phe Val Asn Gln Thr Leu Ala

275 280 285

Ala His Arg Glu Leu Leu Ala Gly Phe Gly Glu Ala Ala Pro Arg Phe

290 295 300

Arg Gly Gln Val Leu Phe Val Val Val Asp Val Ala Ala Asp Asn Glu

305 310 315 320

His Val Leu Gln Tyr Phe Gly Leu Lys Ala Glu Ala Ala Pro Thr Leu

325 330 335

Arg Leu Val Asn Leu Glu Thr Thr Lys Lys Tyr Ala Pro Val Asp Gly

340 345 350

Gly Pro Val Thr Ala Ala Ser Ile Thr Ala Phe Cys His Ala Val Leu

355 360 365

Asn Gly Gln Val Lys Pro Tyr Leu Leu Ser Gln Glu Ile Pro Pro Asp

370 375 380

Trp Asp Gln Arg Pro Val Lys Thr Leu Val Gly Lys Asn Phe Glu Gln

385 390 395 400

Val Ala Phe Asp Glu Thr Lys Asn Val Phe Val Lys Phe Tyr Ala Pro

405 410 415

Trp Cys Thr His Cys Lys Glu Met Ala Pro Ala Trp Glu Ala Leu Ala

420 425 430

Glu Lys Tyr Gln Asp His Glu Asp Ile Ile Ile Ala Glu Leu Asp Ala

435 440 445

Thr Ala Asn Glu Leu Asp Ala Phe Ala Val His Gly Phe Pro Thr Leu

450 455 460

Lys Tyr Phe Pro Ala Gly Pro Gly Arg Lys Val Ile Glu Tyr Lys Ser

465 470 475 480

Thr Arg Asp Leu Glu Thr Phe Ser Lys Phe Leu Asp Asn Gly Gly Val

485 490 495

Leu Pro Thr Glu Glu Pro Pro Glu Glu Pro Ala Ala Pro Phe Pro Glu

500 505 510

Pro Pro Ala Asn Ser Thr Met Gly Ser Lys Glu Glu Leu

515 520 525

<210>82

<211>505

<212>PRT

<213> Human (Homo sapiens)

<220>

<221> Protein disulfide isomerase A3 precursor

<222>(1)..(505)

<223> August 29, 2003 Registration Number: P30101

<400>82

Met Arg Leu Arg Arg Leu Ala Leu Phe Pro Gly Val Ala Leu Leu Leu

1 5 10 15

Ala Ala Ala Arg Leu Ala Ala Ala Ser Asp Val Leu Glu Leu Thr Asp

20 25 30

Asp Asn Phe Glu Ser Arg Ile Ser Asp Thr Gly Ser Ala Gly Leu Met

35 40 45

Leu Val Glu Phe Phe Ala Pro Trp Cys Gly His Cys Lys Arg Leu Ala

50 55 60

Pro Glu Tyr Glu Ala Ala Ala Thr Arg Leu Lys Gly Ile Val Pro Leu

65 70 75 80

Ala Lys Val Asp Cys Thr Ala Asn Thr Asn Thr Cys Asn Lys Tyr Gly

85 90 95

Val Ser Gly Tyr Pro Thr Leu Lys Ile Phe Arg Asp Gly Glu Glu Ala

100 105 110

Gly Ala Tyr Asp Gly Pro Arg Thr Ala Asp Gly Ile Val Ser His Leu

115 120 125

Lys Lys Gln Ala Gly Pro Ala Ser Val Pro Leu Arg Thr Glu Glu Glu Glu

130 135 140

Phe Lys Lys Phe Ile Ser Asp Lys Asp Ala Ser Ile Val Gly Phe Phe

145 150 155 160

Asp Asp Ser Phe Ser Glu Ala His Ser Glu Phe Leu Lys Ala Ala Ser

165 170 175

Asn Leu Arg Asp Asn Tyr Arg Phe Ala His Thr Asn Val Glu Ser Leu

180 185 190

Val Asn Glu Tyr Asp Asp Asn Gly Glu Gly Ile Ile Leu Phe Arg Pro

195 200 205

Ser His Leu Thr Asn Lys Phe Glu Asp Lys Thr Val Ala Tyr Thr Glu

210 215 220

Gln Lys Met Thr Ser Gly Lys Ile Lys Lys Phe Ile Gln Glu Asn Ile

225 230 235 240

Phe Gly Ile Cys Pro His Met Thr Glu Asp Asn Lys Asp Leu Ile Gln

245 250 255

Gly Lys Asp Leu Leu Ile Ala Tyr Tyr Asp Val Asp Tyr Glu Lys Asn

260 265 270

Ala Lys Gly Ser Asn Tyr Trp Arg Asn Arg Val Met Met Val Ala Lys

275 280 285

Lys Phe Leu Asp Ala Gly His Lys Leu Asn Phe Ala Val Ala Ser Arg

290 295 300

Lys Thr Phe Ser His Glu Leu Ser Asp Phe Gly Leu Glu Ser Thr Ala

305 310 315 320

Gly Glu Ile Pro Val Val Ala Ile Arg Thr Ala Lys Gly Glu Lys Phe

325 330 335

Val Met Gln Glu Glu Phe Ser Arg Asp Gly Lys Ala Leu Glu Arg Phe

340 345 350

Leu Gln Asp Tyr Phe Asp Gly Asn Leu Lys Arg Tyr Leu Lys Ser Glu

355 360 365

Pro Ile Pro Glu Ser Asn Asp Gly Pro Val Lys Val Val Val Ala Glu

370 375 380

Asn Phe Asp Glu Ile Val Asn Asn Glu Asn Lys Asp Val Leu Ile Glu

385 390 395 400

Phe Tyr Ala Pro Trp Cys Gly His Cys Lys Asn Leu Glu Pro Lys Tyr

405 410 415

Lys Glu Leu Gly Glu Lys Leu Ser Lys Asp Pro Asn Ile Val Ile Ala

420 425 430

Lys Met Asp Ala Thr Ala Asn Asp Val Pro Ser Pro Tyr Glu Val Arg

435 440 445

Gly Phe Pro Thr Ile Tyr Phe Ser Pro Ala Asn Lys Lys Leu Asn Pro

450 455 460

Lys Lys Tyr Glu Gly Gly Arg Glu Leu Ser Asp Phe Ile Ser Tyr Leu

465 470 475 480

Gln Arg Glu Ala Thr Asn Pro Pro Val Ile Gln Glu Glu Lys Pro Lys

485 490 495

Lys Lys Lys Lys Ala Gln Glu Asp Leu

500 505

<210>83

<211>374

<212>PRT

<213> Human (Homo sapiens)

<220>

<221> alcohol dehydrogenase beta-chain

<222>(1)..(374)

<223> August 29, 2003 Registration number: P00325

<400>83

Ser Thr Ala Gly Lys Val Ile Lys Cys Lys Ala Ala Val Leu Trp Glu

1 5 10 15

Val Lys Lys Pro Phe Ser Ile Glu Asp Val Glu Val Ala Pro Pro Lys

20 25 30

Ala Tyr Glu Val Arg Ile Lys Met Val Ala Val Gly Ile Cys Arg Thr

35 40 45

Asp Asp His Val Val Ser Gly Asn Leu Val Thr Pro Leu Pro Val Ile

50 55 60

Leu Gly His Glu Ala Ala Gly Ile Val Glu Ser Val Gly Glu Gly Val

65 70 75 80

Thr Thr Val Lys Pro Gly Asp Lys Val Ile Pro Leu Phe Thr Pro Gln

85 90 95

Cys Gly Lys Cys Arg Val Cys Lys Asn Pro Glu Ser Asn Tyr Cys Leu

100 105 110

Lys Asn Asp Leu Gly Asn Pro Arg Gly Thr Leu Gln Asp Gly Thr Arg

115 120 125

Arg Phe Thr Cys Arg Gly Lys Pro Ile His His Phe Leu Gly Thr Ser

130 135 140

Thr Phe Ser Gln Tyr Thr Val Val Asp Glu Asn Ala Val Ala Lys Ile

145 150 155 160

Asp Ala Ala Ser Pro Leu Glu Lys Val Cys Leu Ile Gly Cys Gly Phe

165 170 175

Ser Thr Gly Tyr Gly Ser Ala Val Asn Val Ala Lys Val Thr Pro Gly

180 185 190

Ser Thr Cys Ala Val Phe Gly Leu Gly Gly Val Gly Leu Ser Ala Val

195 200 205

Met Gly Cys Lys Ala Ala Gly Ala Ala Arg Ile Ile Ala Val Asp Ile

210 215 220

Asn Lys Asp Lys Phe Ala Lys Ala Lys Glu Leu Gly Ala Thr Glu Cys

225 230 235 240

Ile Asn Pro Gln Asp Tyr Lys Lys Pro Ile Gln Glu Val Leu Lys Glu

245 250 255

Met Thr Asp Gly Gly Val Asp Phe Ser Phe Glu Val Ile Gly Arg Leu

260 265 270

Asp Thr Met Met Ala Ser Leu Leu Cys Cys His Glu Ala Cys Gly Thr

275 280 285

Ser Val Ile Val Gly Val Pro Pro Ala Ser Gln Asn Leu Ser lle Asn

290 295 300

Pro Met Leu Leu Leu Thr Gly Arg Thr Trp Lys Gly Ala Val Tyr Gly

305 310 315 320

Gly Phe Lys Ser Lys Glu Gly Ile Pro Lys Leu Val Ala Asp Phe Met

325 330 335

Ala Lys Lys Phe Ser Leu Asp Ala Leu Ile Thr His Val Leu Pro Phe

340 345 350

Glu Lys Ile Asn Glu Gly Phe Asp Leu Leu His Ser Gly Lys Ser Ile

355 360 365

Arg Thr Val Leu Thr Phe

370

<210>84

<211>241

<212>PRT

<213> Human (Homo sapiens)

<220>

<221> glutathione transferase omega-1

<222>(1)..(241)

<223> August 29, 2003 Registration number: P78417

<400>84

Met Ser Gly Glu Ser Ala Arg Ser Leu Gly Lys Gly Ser Ala Pro Pro

1 5 10 15

Gly Pro Val Pro Glu Gly Ser Ile Arg Ile Tyr Ser Met Arg Phe Cys

20 25 30

Pro Phe Ala Glu Arg Thr Arg Leu Val Leu Lys Ala Lys Gly Ile Arg

35 40 45

His Glu Val Ile Asn Ile Asn Leu Lys Asn Lys Pro Glu Trp Phe Phe

50 55 60

Lys Lys Asn Pro Phe Gly Leu Val Pro Val Leu Glu Asn Ser Gln Gly

65 70 75 80

Gln Leu Ile Tyr Glu Ser Ala Ile Thr Cys Glu Tyr Leu Asp Glu Ala

85 90 95

Tyr Pro Gly Lys Lys Leu Leu Pro Asp Asp Pro Tyr Glu Lys Ala Cys

100 105 110

Gln Lys Met Ile Leu Glu Leu Phe Ser Lys Val Pro Ser Leu Val Gly

115 120 125

Ser Phe Ile Arg Ser Gln Asn Lys Glu Asp Tyr Ala Gly Leu Lys Glu

130 135 140

Glu Phe Arg Lys Glu Phe Thr Lys Leu Glu Glu Val Leu Thr Asn Lys

145 150 155 160

Lys Thr Thr Phe Phe Gly Gly Asn Ser Ile Ser Met Ile Asp Tyr Leu

165 170 175

Ile Trp Pro Trp Phe Glu Arg Leu Glu Ala Met Lys Leu Asn Glu Cys

180 185 190

Val Asp His Thr Pro Lys Leu Lys Leu Trp Met Ala Ala Met Lys Glu

195 200 205

Asp Pro Thr Val Ser Ala Leu Leu Thr Ser Glu Lys Asp Trp Gln Gly

210 215 220

Phe Leu Glu Leu Tyr Leu Gln Asn Ser Pro Glu Ala Cys Asp Tyr Gly

225 230 235 240

Leu

<210>85

<211>999

<212>PRT

<213> Human (Homo sapiens)

<220>

<221>150kDa oxygen-regulated protein precursor (Orp150)

<222>(1)..(999)

<223>August 29, 2003 Registration number: Q9Y4L1

<400>85

Met Ala Asp Lys Val Arg Arg Gln Arg Pro Arg Arg Arg Val Cys Trp

1 5 10 15

Ala Leu Val Ala Val Leu Leu Ala Asp Leu Leu Ala Leu Ser Asp Thr

20 25 30

Leu Ala Val Met Ser Val Asp Leu Gly Ser Glu Ser Met Lys Val Ala

35 40 45

Ile Val Lys Pro Gly Val Pro Met Glu Ile Val Leu Asn Lys Glu Ser

50 55 60

Arg Arg Lys Thr Pro Val Ile Val Thr Leu Lys Glu Asn Glu Arg Phe

65 70 75 80

Phe Gly Asp Ser Ala Ala Ser Met Ala Ile Lys Asn Pro Lys Ala Thr

85 90 95

Leu Arg Tyr Phe Gln His Leu Leu Gly Lys Gln Ala Asp Asn Pro His

100 105 110

Val Ala Leu Tyr Gln Ala Arg Phe Pro Glu His Glu Leu Thr Phe Asp

115 120 125

Pro Gln Arg Gln Thr Val His Phe Gln Ile Ser Ser Gln Leu Gln Phe

130 135 140

Ser Pro Glu Glu Val Leu Gly Met Val Leu Asn Tyr Ser Arg Ser Leu

145 150 155 160

Ala Glu Asp Phe Ala Glu Gln Pro Ile Lys Asp Ala Val Ile Thr Val

165 170 175

Pro Val Phe Phe Asn Gln Ala Glu Arg Arg Ala Val Leu Gln Ala Ala

180 185 190

Arg Met Ala Gly Leu Lys Val Leu Gln Leu Ile Asn Asp Asn Thr Ala

195 200 205

Thr Ala Leu Ser Tyr Gly Val Phe Arg Arg Lys Asp Ile Asn Thr Thr

210 215 220

Ala Gln Asn Ile Met Phe Tyr Asp Met Gly Ser Gly Ser Thr Val Cys

225 230 235 240

Thr Ile Val Thr Tyr Gln Met Val Lys Thr Lys Glu Ala Gly Met Gln

245 250 255

Pro Gln Leu Gln Ile Arg Gly Val Gly Phe Asp Arg Thr Leu Gly Gly

260 265 270

Leu Glu Met Glu Leu Arg Leu Arg Glu Arg Leu Ala Gly Leu Phe Asn

275 280 285

Glu Gln Arg Lys Gly Gln Arg Ala Lys Asp Val Arg Glu Asn Pro Arg

290 295 300

Ala Met Ala Lys Leu Leu Arg Glu Ala Asn Arg Leu Lys Thr Val Leu

305 310 315 320

Ser Ala Asn Ala Asp His Met Ala Gln Ile Glu Gly Leu Met Asp Asp

325 330 335

Val Asp Phe Lys Ala Lys Val Thr Arg Val Glu Phe Glu Glu Leu Cys

340 345 350

Ala Asp Leu Phe Glu Arg Val Pro Gly Pro Val Gln Gln Ala Leu Gln

355 360 365

Ser Ala Glu Met Ser Leu Asp Glu Ile Glu Gln Val Ile Leu Val Gly

370 375 380

Gly Ala Thr Arg Val Pro Arg Val Gln Glu Val Leu Leu Lys Ala Val

385 390 395 400

Gly Lys Glu Glu Leu Gly Lys Asn Ile Asn Ala Asp Glu Ala Ala Ala

405 410 415

Met Gly Ala Val Tyr Gln Ala Ala Ala Leu Ser Lys Ala Phe Lys Val

420 425 430

Lys Pro Phe Val Val Arg Asp Ala Val Val Tyr Pro Ile Leu Val Glu

435 440 445

Phe Thr Arg Glu Val Glu Glu Glu Pro Gly Ile His Ser Leu Lys His

450 455 460

Asn Lys Arg Val Leu Phe Ser Arg Met Gly Pro Tyr Pro Gln Arg Lys

465 470 475 480

Val Ile Thr Phe Asn Arg Tyr Ser His Asp Phe Asn Phe His Ile Asn

485 490 495

Tyr Gly Asp Leu Gly Phe Leu Gly Pro Glu Asp Leu Arg Val Phe Gly

500 505 510

Ser Gln Asn Leu Thr Thr Val Lys Leu Lys Gly Val Gly Asp Ser Phe

515 520 525

Lys Lys Tyr Pro Asp Tyr Glu Ser Lys Gly Ile Lys Ala His Phe Asn

530 535 540

Leu Asp Glu Ser Gly Val Leu Ser Leu Asp Arg Val Glu Ser Val Phe

545 550 555 560

Glu Thr Leu Val Glu Asp Ser Ala Glu Glu Glu Ser Thr Leu Thr Lys

565 570 575

Leu Gly Asn Thr Ile Ser Ser Leu Phe Gly Gly Gly Thr Thr Pro Asp

580 585 590

Ala Lys Glu Asn Gly Thr Asp Thr Val Gln Glu Glu Glu Glu Ser Pro

595 600 605

Ala Glu Gly Ser Lys Asp Glu Pro Gly Glu Gln Val Glu Leu Lys Glu

610 615 620

Glu Ala Glu Ala Pro Val Glu Asp Gly Ser Gln Pro Pro Pro Pro Glu

625 630 635 640

Pro Lys Gly Asp Ala Thr Pro Glu Gly Glu Lys Ala Thr Glu Lys Glu

645 650 655

Asn Gly Asp Lys Ser Glu Ala Gln Lys Pro Ser Glu Lys Ala Glu Ala

660 665 670

Gly Pro Glu Gly Val Ala Pro Ala Pro Glu Gly Glu Lys Lys Gln Lys

675 680 685

Pro Ala Arg Lys Arg Arg Met Val Glu Glu Ile Gly Val Glu Leu Val

690 695 700

Val Leu Asp Leu Pro Asp Leu Pro Glu Asp Lys Leu Ala Gln Ser Val

705 710 715 720

Gln Lys Leu Gln Asp Leu Thr Leu Arg Asp Leu Glu Lys Gln Glu Arg

725 730 735

Glu Lys Ala Ala Asn Ser Leu Glu Ala Phe Ile Phe Glu Thr Gln Asp

740 745 750

Lys Leu Tyr Gln Pro Glu Tyr Gln Glu Val Ser Thr Glu Glu Gln Arg

755 760 765

Glu Glu Ile Ser Gly Lys Leu Ser Ala Ala Ser Thr Trp Leu Glu Asp

770 775 780

Glu Gly Val Gly Ala Thr Thr Val Met Leu Lys Glu Lys Leu Ala Glu

785 790 795 800

Leu Arg Lys Leu Cys Gln Gly Leu Phe Phe Arg Val Glu Glu Arg Lys

805 810 815

Lys Trp Pro Glu Arg Leu Ser Ala Leu Asp Asn Leu Leu Asn His Ser

820 825 830

Ser Met Phe Leu Lys Gly Ala Arg Leu Ile Pro Glu Met Asp Gln Ile

835 840 845

Phe Thr Glu Val Glu Met Thr Thr Leu Glu Lys Val Ile Asn Glu Thr

850 855 860

Trp Ala Trp Lys Asn Ala Thr Leu Ala Glu Gln Ala Lys Leu Pro Ala

865 870 875 880

Thr Glu Lys Pro Val Leu Leu Ser Lys Asp Ile Glu Ala Lys Met Met

885 890 895

Ala Leu Asp Arg Glu Val Gln Tyr Leu Leu Asn Lys Ala Lys Phe Thr

900 905 910

Lys Pro Arg Pro Arg Pro Lys Asp Lys Asn Gly Thr Arg Ala Glu Pro

915 920 925

Pro Leu Asn Ala Ser Ala Ser Asp Gln Gly Glu Lys Val Ile Pro Pro

930 935 940

Ala Gly Gln Thr Glu Asp Ala Glu Pro Ile Ser Glu Pro Glu Lys Val

945 950 955 960

Glu Thr Gly Ser Glu Pro Gly Asp Thr Glu Pro Leu Glu Leu Gly Gly

965 970 975

Pro Gly Ala Glu Pro Glu Gln Lys Glu Gln Ser Thr Gly Gln Lys Arg

980 985 990

Pro Leu Lys Asn Asp Glu Leu

995

<210>86

<211>271

<212>PRT

<213> Human (Homo sapiens)

<220>

<221> peroxidoreductase 4

<222>(1)..(271)

<223> August 29, 2003 Registration number: Q13162

<400>86

Met Glu Ala Leu Pro Leu Leu Ala Ala Thr Thr Pro Asp His Gly Arg

1 5 10 15

His Arg Arg Leu Leu Leu Leu Pro Leu Leu Leu Phe Leu Leu Pro Ala

20 25 30

Gly Ala Val Gln Gly Trp Glu Thr Glu Glu Arg Pro Arg Thr Arg Glu

35 40 45

Glu Glu Cys His Phe Tyr Ala Gly Gly Gln Val Tyr Pro Gly Glu Ala

50 55 60

Ser Arg Val Ser Val Ala Asp His Ser Leu His Leu Ser Lys Ala Lys

65 70 75 80

Ile Ser Lys Pro Ala Pro Tyr Trp Glu Gly Thr Ala Val Ile Asp Gly

85 90 95

Glu Phe Lys Glu Leu Lys Leu Thr Asp Tyr Arg Gly Lys Tyr Leu Val

100 105 110

Phe Phe Phe Tyr Pro Leu Asp Phe Thr Phe Val Cys Pro Thr Glu Ile

115 120 125

Ile Ala Phe Gly Asp Arg Leu Glu Glu Phe Arg Ser Ile Asn Thr Glu

130 135 140

Val Val Ala Cys Ser Val Asp Ser Gln Phe Thr His Leu Ala Trp Ile

145 150 155 160

Asn Thr Pro Arg Arg Gln Gly Gly Leu Gly Pro Ile Arg Ile Pro Leu

165 170 175

Leu Ser Asp Leu Thr His Gln Ile Ser Lys Asp Tyr Gly Val Tyr Leu

180 185 190

Glu Asp Ser Gly His Thr Leu Arg Gly Leu Phe Ile Ile Asp Asp Lys

195 200 205

Gly Ile Leu Arg Gln Ile Thr Leu Asn Asp Leu Pro Val Gly Arg Ser

210 215 220

Val Asp Glu Thr Leu Arg Leu Val Gln Ala Phe Gln Tyr Thr Asp Lys

225 230 235 240

His Gly Glu Val Cys Pro Ala Gly Trp Lys Pro Gly Ser Glu Thr Ile

245 250 255

Ile Pro Asp Pro Ala Gly Lys Leu Lys Tyr Phe Asp Lys Leu Asn

260 265 270

<210>87

<211>288

<212>PRT

<213> Human (Homo sapiens)

<220>

<221>MAWD binding protein

<222>(1)..(288)

<223> August 29, 2003 Registration number: P30039

<400>87

Met Lys Leu Pro Ile Phe Ile Ala Asp Ala Phe Thr Ala Arg Ala Phe

1 5 10 15

Arg Gly Asn Pro Ala Ala Val Cys Leu Leu Glu Asn Glu Leu Asp Glu

20 25 30

Asp Met His Gln Lys Ile Ala Arg Glu Met Asn Leu Ser Glu Thr Ala

35 40 45

Phe Ile Arg Lys Leu His Pro Thr Asp Asn Phe Ala Gln Ser Ser Cys

50 55 60

Phe Gly Leu Arg Trp Phe Thr Pro Ala Ser Glu Val Pro Leu Cys Gly

65 70 75 80

His Ala Thr Leu Ala Ser Ala Ala Val Leu Phe His Lys Ile Lys Asn

85 90 95

Met Asn Ser Thr Leu Thr Phe Val Thr Leu Ser Gly Glu Leu Arg Ala

100 105 110

Arg Arg Ala Glu Asp Gly Ile Val Leu Asp Leu Pro Leu Tyr Pro Ala

115 120 125

His Pro Gln Asp Phe His Glu Val Glu Asp Leu Ile Lys Thr Ala Ile

130 135 140

Gly Asn Thr Leu Val Gln Asp Ile Cys Tyr Ser Pro Asp Thr Gln Lys

145 150 155 160

Leu Leu Val Arg Leu Ser Asp Val Tyr Asn Arg Ser Phe Leu Glu Asn

165 170 175

Leu Lys Val Asn Thr Glu Asn Leu Leu Gln Val Glu Asn Thr Gly Lys

180 185 190

Val Lys Gly Leu Ile Leu Thr Leu Lys Gly Glu Pro Gly Gly Gln Thr

195 200 205

Gln Ala Phe Asp Phe Tyr Ser Arg Tyr Phe Ala Pro Trp Val Gly Val

210 215 220

Ala Glu Asp Pro Val Thr Gly Ser Ala His Ala Val Leu Ser Ser Tyr

225 230 235 240

Trp Ser Gln His Leu Gly Lys Lys Glu Met His Ala Phe Gln Cys Ser

245 250 255

His Arg Gly Gly Glu Leu Gly Ile Ser Leu Arg Pro Asp Gly Arg Val

260 265 270

Asp Ile Arg Gly Gly Ala Ala Val Val Leu Glu Gly Thr Leu Thr Ala

275 280 285

<210>88

<211>511

<212>PRT

<213> Human (Homo sapiens)

<220>

<221> Alpha-amylase 2B precursor

<222>(1)..(511)

<223> August 29, 2003 Registration number: P19961

<400>88

Met Lys Phe Phe Leu Leu Leu Phe Thr Ile Gly Phe Cys Trp Ala Gln

1 5 10 15

Tyr Ser Pro Asn Thr Gln Gln Gly Arg Thr Ser Ile Val His Leu Phe

20 25 30

Glu Trp Arg Trp Val Asp Ile Ala Leu Glu Cys Glu Arg Tyr Leu Ala

35 40 45

Pro Lys Gly Phe Gly Gly Val Gln Val Ser Pro Pro Asn Glu Asn Val

50 55 60

Ala Ile His Asn Pro Phe Arg Pro Trp Trp Glu Arg Tyr Gln Pro Val

65 70 75 80

Ser Tyr Lys Leu Cys Thr Arg Ser Gly Asn Glu Asp Glu Phe Arg Asn

85 90 95

Met Val Thr Arg Cys Asn Asn Val Gly Val Arg Ile Tyr Val Asp Ala

100 105 110

Val Ile Asn His Met Ser Gly Asn Ala Val Ser Ala Gly Thr Ser Ser

115 120 125

Thr Cys Gly Ser Tyr Phe Asn Pro Gly Ser Arg Asp Phe Pro Ala Val

130 135 140

Pro Tyr Ser Gly Trp Asp Phe Asn Asp Gly Lys Cys Lys Thr Gly Ser

145 150 155 160

Gly Asp Ile Glu Asn Tyr Asn Asp Ala Thr Gln Val Arg Asp Cys Arg

165 170 175

Leu Val Gly Leu Leu Asp Leu Ala Leu Glu Lys Asp Tyr Val Arg Ser

180 185 190

Lys Ile Ala Glu Tyr Met Asn His Leu Ile Asp Ile Gly Val Ala Gly

195 200 205

Phe Arg Leu Asp Ala Ser Lys His Met Trp Pro Gly Asp Ile Lys Ala

210 215 220

Ile Leu Asp Lys Leu His Asn Leu Asn Ser Asn Trp Phe Pro Ala Gly

225 230 235 240

Ser Lys Pro Phe Ile Tyr Gln Glu Val Ile Asp Leu Gly Gly Glu Pro

245 250 255

Ile Lys Ser Ser Asp Tyr Phe Gly Asn Gly Arg Val Thr Glu Phe Lys

260 265 270

Tyr Gly Ala Lys Leu Gly Thr Val Ile Arg Lys Trp Asn Gly Glu Lys

275 280 285

Met Ser Tyr Leu Lys Asn Trp Gly Glu Gly Trp Gly Phe Met Pro Ser

290 295 300

Asp Arg Ala Leu Val Phe Val Asp Asn His Asp Asn Gln Arg Gly His

305 310 315 320

Gly Ala Gly Gly Ala Ser Ile Leu Thr Phe Trp Asp Ala Arg Leu Tyr

325 330 335

Lys Met Ala Val Gly Phe Met Leu Ala His Pro Tyr Gly Phe Thr Arg

340 345 350

Val Met Ser Ser Tyr Arg Trp Pro Arg Gln Phe Gln Asn Gly Asn Asp

355 360 365

Val Asn Asp Trp Val Gly Pro Pro Asn Asn Asn Asn Gly Val Ile Lys Glu

370 375 380

Val Thr Ile Asn Pro Asp Thr Thr Cys Gly Asn Asp Trp Val Cys Glu

385 390 395 400

His Arg Trp Arg Gln Ile Arg Asn Met Val Asn Phe Arg Asn Val Val

405 410 415

Asp Gly Gln Pro Phe Thr Asn Trp Tyr Asp Asn Gly Ser Asn Gln Val

420 425 430

Ala Phe Gly Arg Gly Asn Arg Gly Phe Ile Val Phe Asn Asn Asp Asp

435 440 445

Trp Thr Phe Ser Leu Thr Leu Gln Thr Gly Leu Pro Ala Gly Thr Tyr

450 455 460

Cys Asp Val Ile Ser Gly Asp Lys Ile Asn Gly Asn Cys Thr Gly Ile

465 470 475 480

Lys Ile Tyr Val Ser Asp Asp Gly Lys Ala His Phe Ser Ile Ser Asn

485 490 495

Ser Ala Glu Asp Pro Phe Ile Ala Ile His Ala Glu Ser Lys Leu

500 505 510

<210>89

<211>511

<212>PRT

<213> Human (Homo sapiens)

<220>

<221> Pancreatic Alpha-amylase precursor

<222>(1)..(511)

<223> August 29, 2003 Registration number: P04746

<400>89

Met Lys Phe Phe Leu Leu Leu Phe Thr Ile Gly Phe Cys Trp Ala Gln

1 5 10 15

Tyr Ser Pro Asn Thr Gln Gln Gly Arg Thr Ser Ile Val His Leu Phe

20 25 30

Glu Trp Arg Trp Val Asp Ile Ala Leu Glu Cys Glu Arg Tyr Leu Ala

35 40 45

Pro Lys Gly Phe Gly Gly Val Gln Val Ser Pro Pro Asn Glu Asn Val

50 55 60

Ala Ile Tyr Asn Pro Phe Arg Pro Trp Trp Glu Arg Tyr Gln Pro Val

65 70 75 80

Ser Tyr Lys Leu Cys Thr Arg Ser Gly Asn Glu Asp Glu Phe Arg Asn

85 90 95

Met Val Thr Arg Cys Asn Asn Val Gly Val Arg Ile Tyr Val Asp Ala

100 105 110

Val Ile Asn His Met Cys Gly Asn Ala Val Ser Ala Gly Thr Ser Ser

115 120 125

Thr Cys Gly Ser Tyr Phe Asn Pro Gly Ser Arg Asp Phe Pro Ala Val

130 135 140

Pro Tyr Ser Gly Trp Asp Phe Asn Asp Gly Lys Cys Lys Thr Gly Ser

145 150 155 160

Gly Asp Ile Glu Asn Tyr Asn Asp Ala Thr Gln Val Arg Asp Cys Arg

165 170 175

Leu Thr Gly Leu Leu Asp Leu Ala Leu Glu Lys Asp Tyr Val Arg Ser

180 185 190

Lys Ile Ala Glu Tyr Met Asn His Leu Ile Asp Ile Gly Val Ala Gly

195 200 205

Phe Arg Leu Asp Ala Ser Lys His Met Trp Pro Gly Asp Ile Lys Ala

210 215 220

Ile Leu Asp Lys Leu His Asn Leu Asn Ser Asn Trp Phe Pro Ala Gly

225 230 235 240

Ser Lys Pro Phe Ile Tyr Gln Glu Val Ile Asp Leu Gly Gly Glu Pro

245 250 255

Ile Lys Ser Ser Asp Tyr Phe Gly Asn Gly Arg Val Thr Glu Phe Lys

260 265 270

Tyr Gly Ala Lys Leu Gly Thr Val Ile Arg Lys Trp Asn Gly Glu Lys

275 280 285

Met Ser Tyr Leu Lys Asn Trp Gly Glu Gly Trp Gly Phe Val Pro Ser

290 295 300

Asp Arg Ala Leu Val Phe Val Asp Asn His Asp Asn Gln Arg Gly His

305 310 315 320

Gly Ala Gly Gly Ala Ser Ile Leu Thr Phe Trp Asp Ala Arg Leu Tyr

325 330 335

Lys Met Ala Val Gly Phe Met Leu Ala His Pro Tyr Gly Phe Thr Arg

340 345 350

Val Met Ser Ser Tyr Arg Trp Pro Arg Gln Phe Gln Asn Gly Asn Asp

355 360 365

Val Asn Asp Trp Val Gly Pro Pro Asn Asn Asn Asn Gly Val Ile Lys Glu

370 375 380

Val Thr Ile Asn Pro Asp Thr Thr Cys Gly Asn Asp Trp Val Cys Glu

385 390 395 400

His Arg Trp Arg Gln Ile Arg Asn Met Val Ile Phe Arg Asn Val Val

405 410 415

Asp Gly Gln Pro Phe Thr Asn Trp Tyr Asp Asn Gly Ser Asn Gln Val

420 425 430

Ala Phe Gly Arg Gly Asn Arg Gly Phe Ile Val Phe Asn Asn Asp Asp

435 440 445

Trp Ser Phe Ser Leu Thr Leu Gln Thr Gly Leu Pro Ala Gly Thr Tyr

450 455 460

Cys Asp Val Ile Ser Gly Asp Lys Ile Asn Gly Asn Cys Thr Gly Ile

465 470 475 480

Lys Ile Tyr Val Ser Asp Asp Gly Lys Ala His Phe Ser Ile Ser Asn

485 490 495

Ser Ala Glu Asp Pro Phe Ile Ala Ile His Ala Glu Ser Lys Leu

500 505 510

<210>90

<211>553

<212>PRT

<213> Human (Homo sapiens)

<220>

<221> ATP synthase Alpha-chain

<222>(1)..(553)

<223> August 29, 2003 Registration number: P25705

<400>90

Met Leu Ser Val Arg Val Ala Ala Ala Val Val Arg Ala Leu Pro Arg

1 5 10 15

Arg Ala Gly Leu Val Ser Arg Asn Ala Leu Gly Ser Ser Phe Ile Ala

20 25 30

Ala Arg Asn Phe His Ala Ser Asn Thr His Leu Gln Lys Thr Gly Thr

35 40 45

Ala Glu Met Ser Ser Ile Leu Glu Glu Arg Ile Leu Gly Ala Asp Thr

50 55 60

Ser Val Asp Leu Glu Glu Thr Gly Arg Val Leu Ser Ile Gly Asp Gly

65 70 75 80

Ile Ala Arg Val His Gly Leu Arg Asn Val Gln Ala Glu Glu Met Val

85 90 95

Glu Phe Ser Ser Gly Leu Lys Gly Met Ser Leu Asn Leu Glu Pro Asp

100 105 110

Asn Val Gly Val Val Val Phe Gly Asn Asp Lys Leu Ile Lys Glu Gly

115 120 125

Asp Ile Val Lys Arg Thr Gly Ala Ile Val Asp Val Pro Val Gly Glu

130 135 140

Glu Leu Leu Gly Arg Val Val Asp Ala Leu Gly Asn Ala Ile Asp Gly

145 150 155 160

Lys Gly Pro Ile Gly Ser Lys Thr Arg Arg Arg Val Gly Leu Lys Ala

165 170 175

Pro Gly Ile Ile Pro Arg Ile Ser Val Arg Glu Pro Met Gln Thr Gly

180 185 190

Ile Lys Ala Val Asp Ser Leu Val Pro Ile Gly Arg Gly Gln Arg Glu

195 200 205

Leu Ile Ile Gly Asp Arg Gln Thr Gly Lys Thr Ser Ile Ala Ile Asp

210 215 220

Thr Ile Ile Asn Gln Lys Arg Phe Asn Asp Gly Ser Asp Glu Lys Lys

225 230 235 240

Lys Leu Tyr Cys Ile Tyr Val Ala Ile Gly Gln Lys Arg Ser Thr Val

245 250 255

Ala Gln Leu Val Lys Arg Leu Thr Asp Ala Asp Ala Met Lys Tyr Thr

260 265 270

Ile Val Val Ser Ala Thr Ala Ser Asp Ala Ala Pro Leu Gln Tyr Leu

275 280 285

Ala Pro Tyr Ser Gly Cys Ser Met Gly Glu Tyr Phe Arg Asp Asn Gly

290 295 300

Lys His Ala Leu Ile Ile Tyr Asp Asp Leu Ser Lys Gln Ala Val Ala

305 310 315 320

Tyr Arg Gln Met Ser Leu Leu Leu Arg Arg Pro Pro Gly Arg Glu Ala

325 330 335

Tyr Pro Gly Asp Val Phe Tyr Leu His Ser Arg Leu Leu Glu Arg Ala

340 345 350

Ala Lys Met Asn Asp Ala Phe Gly Gly Gly Ser Leu Thr Ala Leu Pro

355 360 365

Val Ile Glu Thr Gln Ala Gly Asp Val Ser Ala Tyr Ile Pro Thr Asn

370 375 380

Val Ile Ser Ile Thr Asp Gly Gln Ile Phe Leu Glu Thr Glu Leu Phe

385 390 395 400

Tyr Lys Gly Ile Arg Pro Ala Ile Asn Val Gly Leu Ser Val Ser Arg

405 410 415

Val Gly Ser Ala Ala Gln Thr Arg Ala Met Lys Gln Val Ala Gly Thr

420 425 430

Met Lys Leu Glu Leu Ala Gln Tyr Arg Glu Val Ala Ala Phe Ala GTn

435 440 445

Phe Gly Ser Asp Leu Asp Ala Ala Thr GTn Gln Leu Leu Ser Arg Gly

450 455 460

Val Arg Leu Thr Glu Leu Leu Lys GTn Gly Gln Tyr Ser Pro Met Ala

465 470 475 480

Ile Glu Glu Gln Val Ala Val Ile Tyr Ala Gly Val Arg Gly Tyr Leu

485 490 495

Asp Lys Leu Glu Pro Ser Lys Ile Thr Lys Phe Glu Asn Ala Phe Leu

500 505 510

Ser His Val Val Ser GTn His Gln Ala Leu Leu Gly Thr Ile Arg Ala

515 520 525

Asp Gly Lys Ile Ser Glu GTn Ser Asp Ala Lys Leu Lys Glu Ile Val

530 535 540

Thr Asn Phe Leu Ala Gly Phe Glu Ala

545 550

<210>91

<211>742

<212>PRT

<213> Human (Homo sapiens)

<220>

<221> Bile salt-activated lipase precursor

<222>(1)..(742)

<223> August 29, 2003 Registration Number: P19835

<400>91

Met Gly Arg Leu Gln Leu Val Val Leu Gly Leu Thr Cys Cys Trp Ala

1 5 10 15

Val Ala Ser Ala Ala Lys Leu Gly Ala Val Tyr Thr Glu Gly Gly Phe

20 25 30

Val Glu Gly Val Asn Lys Lys Leu Gly Leu Leu Gly Asp Ser Val Asp

35 40 45

Ile Phe Lys Gly Ile Pro Phe Ala Ala Pro Thr Lys Ala Leu Glu Asn

50 55 60

Pro Gln Pro His Pro Gly Trp Gln Gly Thr Leu Lys Ala Lys Asn Phe

65 70 75 80

Lys Lys Arg Cys Leu GTn Ala Thr Ile Thr GTn Asp Ser Thr Tyr Gly

85 90 95

Asp Glu Asp Cys Leu Tyr Leu Asn Ile Trp Val Pro Gln Gly Arg Lys

100 105 110

Gln Val Ser Arg Asp Leu Pro Val Met Ile Trp Ile Tyr Gly Gly Ala

115 120 125

Phe Leu Met Gly Ser Gly His Gly Ala Asn Phe Leu Asn Asn Tyr Leu

130 135 140

Tyr Asp Gly Glu Glu Ile Ala Thr Arg Gly Asn Val Ile Val Val Thr

145 150 155 160

Phe Asn Tyr Arg Val Gly Pro Leu Gly Phe Leu Ser Thr Gly Asp Ala

165 170 175

Asn Leu Pro Gly Asn Tyr Gly Leu Arg Asp Gln His Met Ala Ile Ala

180 185 190

Trp Val Lys Arg Asn Ile Ala Ala Phe Gly Gly Asp Pro Asn Asn Ile

195 200 205

Thr Leu Phe Gly Glu Ser Ala Gly Gly Ala Ser Val Ser Leu Gln Thr

210 215 220

Leu Ser Pro Tyr Asn Lys Gly Leu Ile Arg Arg Ala Ile Ser Gln Ser

225 230 235 240

Gly Val Ala Leu Ser Pro Trp Val Ile Gln Lys Asn Pro Leu Phe Trp

245 250 255

Ala Lys Lys Val Ala Glu Lys Val Gly Cys Pro Val Gly Asp Ala Ala

260 265 270

Arg Met Ala Gln Cys Leu Lys Val Thr Asp Pro Arg Ala Leu Thr Leu

275 280 285

Ala Tyr Lys Val Pro Leu Ala Gly Leu Glu Tyr Pro Met Leu His Tyr

290 295 300

Val Gly Phe Val Pro Val Ile Asp Gly Asp Phe Ile Pro Ala Asp Pro

305 310 315 320

Ile Asn Leu Tyr Ala Asn Ala Ala Asp Ile Asp Tyr Ile Ala Gly Thr

325 330 335

Asn Asn Met Asp Gly His Ile Phe Ala Ser Ile Asp Met Pro Ala Ile

340 345 350

Asn Lys Gly Asn Lys Lys Val Thr Glu Glu Asp Phe Tyr Lys Leu Val

355 360 365

Ser Glu Phe Thr Ile Thr Lys Gly Leu Arg Gly Ala Lys Thr Thr Phe

370 375 380

Asp Val Tyr Thr Glu Ser Trp Ala Gln Asp Pro Ser Gln Glu Asn Lys

385 390 395 400

Lys Lys Thr Val Val Asp Phe Glu Thr Asp Val Leu Phe Leu Val Pro

405 410 415

Thr Glu Ile Ala Leu Ala Gln His Arg Ala Asn Ala Lys Ser Ala Lys

420 425 430

Thr Tyr Ala Tyr Leu Phe Ser His Pro Ser Arg Met Pro Val Tyr Pro

435 440 445

Lys Trp Val Gly Ala Asp His Ala Asp Asp Ile Gln Tyr Val Phe Gly

450 455 460

Lys Pro Phe Ala Thr Pro Thr Gly Tyr Arg Pro Gln Asp Arg Thr Val

465 470 475 480

Ser Lys Ala Met Ile Ala Tyr Trp Thr Asn Phe Ala Lys Thr Gly Asp

485 490 495

Pro Asn Met Gly Asp Ser Ala Val Pro Thr His Trp Glu Pro Tyr Thr

500 505 510

Thr Glu Asn Ser Gly Tyr Leu Glu Ile Thr Lys Lys Met Gly Ser Ser

515 520 525

Ser Met Lys Arg Ser Leu Arg Thr Asn Phe Leu Arg Tyr Trp Thr Leu

530 535 540

Thr Tyr Leu Ala Leu Pro Thr Val Thr Asp Gln Glu Ala Thr Pro Val

545 550 555 560

Pro Pro Thr Gly Asp Ser Glu Ala Thr Pro Val Pro Pro Thr Gly Asp

565 570 575

Ser Glu Thr Ala Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro

580 585 590

Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly

595 600 605

Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro

610 615 620

Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr

625 630 635 640

Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala

645 650 655

Pro Pro Val Pro Pro Thr Gly Asp Ala Gly Pro Pro Pro Val Pro Pro

660 665 670

Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly

675 680 685

Ala Pro Pro Val Thr Pro Thr Gly Asp Ser Glu Thr Ala Pro Val Pro

690 695 700

Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser

705 710 715 720

Glu Ala Ala Pro Val Pro Pro Thr Asp Asp Ser Lys Glu Ala Gln Met

725 730 735

Pro Ala Val Ile Arg Phe

740

<210>92

<211>467

<212>PRT

<213> Human (Homo sapiens)

<220>

<221> Pancrelipase-associated protein precursor

<222>(1)..(467)

<223> August 29, 2003 Registration number: P54315

<400>92

Met Leu Ile Phe Trp Thr Ile Thr Leu Phe Leu Leu Gly Ala Ala Lys

1 5 10 15

Gly Lys Glu Val Cys Tyr Glu Asp Leu Gly Cys Phe Ser Asp Thr Glu

20 25 30

Pro Trp Gly Gly Thr Ala Ile Arg Pro Leu Lys Ile Leu Pro Trp Ser

35 40 45

Pro Glu Lys Ile Gly Thr Arg Phe Leu Leu Tyr Thr Asn Glu Asn Pro

50 55 60

Asn Asn Phe Gln Ile Leu Leu Leu Ser Asp Pro Ser Thr Ile Glu Ala

65 70 75 80

Ser Asn Phe Gln Met Asp Arg Lys Thr Arg Phe Ile Ile His Gly Phe

85 90 95

Ile Asp Lys Gly Asp Glu Ser Trp Val Thr Asp Met Cys Lys Lys Leu

100 105 110

Phe Glu Val Glu Glu Val Asn Cys Ile Cys Val Asp Trp Lys Lys Gly

115 120 125

Ser Gln Ala Thr Tyr Thr Gln Ala Ala Asn Asn Val Arg Val Val Gly

130 135 140

Ala Gln Val Ala Gln Met Leu Asp Ile Leu Leu Thr Glu Tyr Ser Tyr

145 150 155 160

Pro Pro Ser Lys Val His Leu Ile Gly His Ser Leu Gly Ala His Val

165 170 175

Ala Gly Glu Ala Gly Ser Lys Thr Pro Gly Leu Ser Arg Ile Thr Gly

180 185 190

Leu Asp Pro Val Glu Ala Ser Phe Glu Ser Thr Pro Glu Glu Val Arg

195 200 205

Leu Asp Pro Ser Asp Ala Asp Phe Val Asp Val Ile His Thr Asp Ala

210 215 220

Ala Pro Leu Ile Pro Phe Leu Gly Phe Gly Thr Asn Gln Gln Met Gly

225 230 235 240

His Leu Asp Phe Phe Pro Asn Gly Gly Glu Ser Met Pro Gly Cys Lys

245 250 255

Lys Asn Ala Leu Ser Gln Ile Val Asp Leu Asp Gly Ile Trp Ala Gly

260 265 270

Thr Arg Asp Phe Val Ala Cys Asn His Leu Arg Ser Tyr Lys Tyr Tyr

275 280 285

Leu Glu Ser Ile Leu Asn Pro Asp Gly Phe Ala Ala Tyr Pro Cys Thr

290 295 300

Ser Tyr Lys Ser Phe Glu Ser Asp Lys Cys Phe Pro Cys Pro Asp Gln

305 310 315 320

Gly Cys Pro Gln Met Gly His Tyr Ala Asp Lys Phe Ala Gly Arg Thr

325 330 335

Ser Glu Glu Gln Gln Lys Phe Phe Leu Asn Thr Gly Glu Ala Ser Asn

340 345 350

Phe Ala Arg Trp Arg Tyr Gly Val Ser Ile Thr Leu Ser Gly Arg Thr

355 360 365

Ala Thr Gly Gln Ile Lys Val Ala Leu Phe Gly Asn Lys Gly Asn Thr

370 375 380

His Gln Tyr Ser Ile Phe Arg Gly Ile Leu Lys Pro Gly Ser Thr His

385 390 395 400

Ser Tyr Glu Phe Asp Ala Lys Leu Asp Val Gly Thr Ile Glu Lys Val

405 410 415

Lys Phe Leu Trp Asn Asn Asn Val Ile Asn Pro Thr Leu Pro Lys Val

420 425 430

Gly Ala Thr Lys Ile Thr Val Gln Lys Gly Glu Glu Lys Thr Val Tyr

435 440 445

Asn Phe Cys Ser Glu Asp Thr Val Arg Glu Asp Thr Leu Leu Thr Leu

450 455 460

Thr Pro Cys

465

<210>93

<211>469

<212>PRT

<213> Human (Homo sapiens)

<220>

<221> Pancrelipase-associated protein 2 precursor

<222>(1)..(469)

<223> August 29, 2003 Registration number: P54317

<400>93

Met Leu Pro Pro Trp Thr Leu Gly Leu Leu Leu Leu Ala Thr Val Arg

1 5 10 15

Gly Lys Glu Val Cys Tyr Gly Gln Leu Gly Cys Phe Ser Asp Glu Lys

20 25 30

Pro Trp Ala Gly Thr Leu Gln Arg Pro Val Lys Leu Leu Pro Trp Ser

35 40 45

Pro Glu Asp Ile Asp Thr Arg Phe Leu Leu Tyr Thr Asn Glu Asn Pro

50 55 60

Asn Asn Phe Gln Leu Ile Thr Gly Thr Glu Pro Asp Thr Ile Glu Ala

65 70 75 80

Ser Asn Phe Gln Leu Asp Arg Lys Thr Arg Phe Ile Ile His Gly Phe

85 90 95

Leu Asp Lys Ala Glu Asp Ser Trp Pro Ser Asp Met Cys Lys Lys Met

100 105 110

Phe Glu Val Glu Lys Val Asn Cys Ile Cys Val Asp Trp Arg His Gly

115 120 125

Ser Arg Ala Met Tyr Thr Gln Ala Val Gln Asn Ile Arg Val Val Gly

130 135 140

Ala Glu Thr Ala Phe Leu Ile Gln Ala Leu Ser Thr Gln Leu Gly Tyr

145 150 155 160

Ser Leu Glu Asp Val His Val Ile Gly His Ser Leu Gly Ala His Thr

165 170 175

Ala Ala Glu Ala Gly Arg Arg Leu Gly Gly Arg Val Gly Arg Ile Thr

180 185 190

Gly Leu Asp Pro Ala Gly Pro Cys Phe Gln Asp Glu Pro Glu Glu Val

195 200 205

Arg Leu Asp Pro Ser Asp Ala Val Phe Val Asp Val Ile His Thr Asp

210 215 220

Ser Ser Pro Ile Val Pro Ser Leu Gly Phe Gly Met Ser Gln Lys Val

225 230 235 240

Gly His Leu Asp Phe Phe Pro Asn Gly Gly Lys Glu Met Pro Gly Cys

245 250 255

Lys Lys Asn Val Leu Ser Thr Ile Thr Asp Ile Asp Gly Ile Trp Glu

260 265 270

Gly Ile Gly Gly Phe Val Ser Cys Asn His Leu Arg Ser Phe Glu Tyr

275 280 285

Tyr Ser Ser Ser Val Leu Asn Pro Asp Gly Phe Leu Gly Tyr Pro Cys

290 295 300

Ala Ser Tyr Asp Glu Phe Gln Glu Ser Lys Cys Phe Pro Cys Pro Ala

305 310 315 320

Glu Gly Cys Pro Lys Met Gly His Tyr Ala Asp Gln Phe Lys Gly Lys

325 330 335

Thr Ser Ala Val Glu Gln Thr Phe Phe Leu Asn Thr Gly Glu Ser Gly

340 345 350

Asn Phe Thr Ser Trp Arg Tyr Lys Val Ser Val Thr Leu Ser Gly Lys

355 360 365

Glu Lys Val Asn Gly Tyr Ile Arg Ile Ala Leu Tyr Gly Ser Asn Glu

370 375 380

Asn Ser Lys Gln Tyr Glu Ile Phe Lys Gly Ser Leu Lys Pro Asp Ala

385 390 395 400

Ser His Thr Cys Ala Ile Asp Val Asp Phe Asn Val Gly Lys Ile Gln

405 410 415

Lys Val Lys Phe Leu Trp Asn Lys Arg Gly Ile Asn Leu Ser Glu Pro

420 425 430

Lys Leu Gly Ala Ser Gln Ile Thr Val Gln Ser Gly Glu Asp Gly Thr

435 440 445

Glu Tyr Asn Phe Cys Ser Ser Asp Thr Val Glu Glu Asn Val Leu Gln

450 455 460

Ser Leu Tyr Pro Cys

465

<210>94

<211>465

<212>PRT

<213> Human (Homo sapiens)

<220>

<221> Pancreatic triacylglycerol lipase precursor

<222>(1)..(465)

<223> August 29, 2003 Registration number: P16233

<400>94

Met Leu Pro Leu Trp Thr Leu Ser Leu Leu Leu Gly Ala Val Ala Gly

1 5 10 15

Lys Glu Val Cys Tyr Glu Arg Leu Gly Cys Phe Ser Asp Asp Ser Pro

20 25 30

Trp Ser Gly Ile Thr Glu Arg Pro Leu His Ile Leu Pro Trp Ser Pro

35 40 45

Lys Asp Val Asn Thr Arg Phe Leu Leu Tyr Thr Asn Glu Asn Pro Asn

50 55 60

Asn Phe Gln Glu Val Ala Ala Asp Ser Ser Ser Ile Ser Gly Ser Asn

65 70 75 80

Phe Lys Thr Asn Arg Lys Thr Arg Phe Ile Ile His Gly Phe Ile Asp

85 90 95

Lys Gly Glu Glu Asn Trp Leu Ala Asn Val Cys Lys Asn Leu Phe Lys

100 105 110

Val Glu Ser Val Asn Cys Ile Cys Val Asp Trp Lys Gly Gly Ser Arg

115 120 125

Thr Gly Tyr Thr Gln Ala Ser Gln Asn Ile Arg Ile Val Gly Ala Glu

130 135 140

Val Ala Tyr Phe Val Glu Phe Leu Gln Ser Ala Phe Gly Tyr Ser Pro

145 150 155 160

Ser Asn Val His Val Ile Gly His Ser Leu Gly Ala His Ala Ala Gly

165 170 175

Glu Ala Gly Arg Arg Thr Asn Gly Thr Ile Gly Arg Ile Thr Gly Leu

180 185 190

Asp Pro Ala Glu Pro Cys Phe Gln Gly Thr Pro Glu Leu Val Arg Leu

195 200 205

Asp Pro Ser Asp Ala Lys Phe Val Asp Val Ile His Thr Asp Gly Ala

210 215 220

Pro Ile Val Pro Asn Leu Gly Phe Gly Met Ser Gln Val Val Gly His

225 230 235 240

Leu Asp Phe Phe Pro Asn Gly Gly Val Glu Met Pro Gly Cys Lys Lys

245 250 255

Asn Ile Leu Ser Gln Ile Val Asp Ile Asp Gly Ile Trp Glu Gly Thr

260 265 270

Arg Asp Phe Ala Ala Cys Asn His Leu Arg Ser Tyr Lys Tyr Tyr Thr

275 280 285

Asp Ser Ile Val Asn Pro Asp Gly Phe Ala Gly Phe Pro Cys Ala Ser

290 295 300

Tyr Asn Val Phe Thr Ala Asn Lys Cys Phe Pro Cys Pro Ser Gly Gly

305 310 315 320

Cys Pro Gln Met Gly His Tyr Ala Asp Arg Tyr Pro Gly Lys Thr Asn

325 330 335

Asp Val Gly Gln Lys Phe Tyr Leu Asp Thr Gly Asp Ala Ser Asn Phe

340 345 350

Ala Arg Trp Arg Tyr Lys Val Ser Val Thr Leu Ser Gly Lys Lys Val

355 360 365

Thr Gly His Ile Leu Val Ser Leu Phe Gly Asn Lys Gly Asn Ser Lys

370 375 380

Gln Tyr Glu Ile Phe Lys Gly Thr Leu Lys Pro Asp Ser Thr His Ser

385 390 395 400

Asn Glu Phe Asp Ser Asp Val Asp Val Gly Asp Leu Gln Met Val Lys

405 410 415

Phe Ile Trp Tyr Asn Asn Val Ile Asn Pro Thr Leu Pro Arg Val Gly

420 425 430

Ala Ser Lys Ile Ile Val Glu Thr Asn Val Gly Lys Gln Phe Asn Phe

435 440 445

Cys Ser Pro Glu Thr Val Arg Glu Glu Val Leu Leu Thr Leu Thr Pro

450 455 460

Cys

465

<210>95

<211>572

<212>PRT

<213> Human (Homo sapiens)

<220>

<221> dihydropyrimidinase-related protein 2

<222>(1)..(572)

<223> August 29, 2003 Registration number: Q16555

<400>95

Met Ser Tyr Gln Gly Lys Lys Asn Ile Pro Arg Ile Thr Ser Asp Arg

1 5 10 15

Leu Leu Ile Lys Gly Gly Lys Ile Val Asn Asp Asp Gln Ser Phe Tyr

20 25 30

Ala Asp Ile Tyr Met Glu Asp Gly Leu Ile Lys Gln Ile Gly Glu Asn

35 40 45

Leu Ile Val Pro Gly Gly Val Lys Thr Ile Glu Ala His Ser Arg Met

50 55 60

Val Ile Pro Gly Gly Ile Asp Val His Thr Arg Phe Gln Met Pro Asp

65 70 75 80

Gln Gly Met Thr Ser Ala Asp Asp Phe Phe Gln Gly Thr Lys Ala Ala

85 90 95

Leu Ala Gly Gly Thr Thr Met Ile Ile Asp His Val Val Pro Glu Pro

100 105 110

Gly Thr Ser Leu Leu Ala Ala Phe Asp Gln Trp Arg Glu Trp Ala Asp

115 120 125

Ser Lys Ser Cys Cys Asp Tyr Ser Leu His Val Asp Ile Ser Glu Trp

130 135 140

His Lys Gly Ile Gln Glu Glu Met Glu Ala Leu Val Lys Asp His Gly

145 150 155 160

Val Asn Ser Phe Leu Val Tyr Met Ala Phe Lys Asp Arg Phe Gln Leu

165 170 175

Thr Asp Cys Gln Ile Tyr Glu Val Leu Ser Val Ile Arg Asp Ile Gly

180 185 190

Ala Ile Ala Gln Val His Ala Glu Asn Gly Asp Ile Ile Ala Glu Glu

195 200 205

Gln Gln Arg Ile Leu Asp Leu Gly Ile Thr Gly Pro Glu Gly His Val

210 215 220

Leu Ser Arg Pro Glu Glu Val Glu Ala Glu Ala Val Asn Arg Ala Ile

225 230 235 240

Thr Ile Ala Asn Gln Thr Asn Cys Pro Leu Tyr Ile Thr Lys Val Met

245 250 255

Ser Lys Ser Ser Ala Glu Val Ile Ala Gln Ala Arg Lys Lys Gly Thr

260 265 270

Val Val Tyr Gly Glu Pro Ile Thr Ala Ser Leu Gly Thr Asp Gly Ser

275 280 285

His Tyr Trp Ser Lys Asn Trp Ala Lys Ala Ala Ala Phe Val Thr Ser

290 295 300

Pro Pro Leu Ser Pro Asp Pro Thr Thr Pro Asp Phe Leu Asn Ser Leu

305 310 315 320

Leu Ser Cys Gly Asp Leu Gln Val Thr Gly Ser Ala His Cys Thr Phe

325 330 335

Asn Thr Ala Gln Lys Ala Val Gly Lys Asp Asn Phe Thr Leu Ile Pro

340 345 350

Glu Gly Thr Asn Gly Thr Glu Glu Arg Met Ser Val Ile Trp Asp Lys

355 360 365

Ala Val Val Thr Gly Lys Met Asp Glu Asn Gln Phe Val Ala Val Thr

370 375 380

Ser Thr Asn Ala Ala Lys Val Phe Asn Leu Tyr Pro Arg Lys Gly Arg

385 390 395 400

Ile Ala Val Gly Ser Asp Ala Asp Leu Val Ile Trp Asp Pro Asp Ser

405 410 415

Val Lys Thr Ile Ser Ala Lys Thr His Asn Ser Ser Leu Glu Tyr Asn

420 425 430

Ile Phe Glu Gly Met Glu Cys Arg Gly Ser Pro Leu Val Val Ile Ser

435 440 445

Gln Gly Lys Ile Val Leu Glu Asp Gly Thr Leu His Val Thr Glu Gly

450 455 460

Ser Gly Arg Tyr Ile Pro Arg Lys Pro Phe Pro Asp Phe Val Tyr Lys

465 470 475 480

Arg Ile Lys Ala Arg Ser Arg Leu Ala Glu Leu Arg Gly Val Pro Arg

485 490 495

Gly Leu Tyr Asp Gly Pro Val Cys Glu Val Ser Val Thr Pro Lys Thr

500 505 510

Val Thr Pro Ala Ser Ser Ala Lys Thr Ser Pro Ala Lys Gln Gln Ala

515 520 525

Pro Pro Val Arg Asn Leu His Gln Ser Gly Phe Ser Leu Ser Gly Ala

530 535 540

Gln Ile Asp Asp Asn Ile Pro Arg Arg Thr Thr Gln Arg Ile Val Ala

545 550 555 560

Pro Pro Gly Gly Arg Ala Asn Ile Thr Ser Leu Gly

565 570

<210>96

<211>500

<212>PRT

<213> Human (Homo sapiens)

<220>

<221> Mitochondrial 4-aminobutyrate aminotransferase precursor

<222>(1)..(500)

<223> August 29, 2003 Registration number: P80404

<400>96

Met Ala Ser Met Leu Leu Ala Gln Arg Leu Ala Cys Ser Phe Gln His

1 5 10 15

Thr Tyr Arg Leu Leu Val Pro Gly Ser Arg His Ile Ser Gln Ala Ala

20 25 30

Ala Lys Val Asp Val Glu Phe Asp Tyr Asp Gly Pro Leu Met Lys Thr

35 40 45

Glu Val Pro Gly Pro Arg Ser Gln Glu Leu Met Lys Gln Leu Asn Ile

50 55 60

Ile Gln Asn Ala Glu Ala Val His Phe Phe Cys Asn Tyr Glu Glu Ser

65 70 75 80

Arg Gly Asn Tyr Leu Val Asp Val Asp Gly Asn Arg Met Leu Asp Leu

85 90 95

Tyr Ser Gln Ile Ser Ser Val Pro Ile Gly Tyr Ser Asp Pro Ala Leu

100 105 110

Val Lys Leu Ile Gln Gln Pro Gln Asn Ala Ser Met Phe Val Asn Arg

115 120 125

Pro Ala Leu Glu Ile Leu Pro Pro Glu Asn Phe Val Glu Lys Leu Arg

130 135 140

Gln Ser Leu Leu Ser Val Ala Pro Lys Gly Met Ser Gln Leu Ile Thr

145 150 155 160

Met Ala Cys Gly Ser Cys Ser Asn Glu Asn Ala Leu Lys Thr Ile Phe

165 170 175

Met Trp Tyr Arg Ser Lys Glu Arg Gly Gln Arg Gly Phe Ser Lys Glu

180 185 190

Glu Leu Glu Thr Cys Met Ile Asn Gln Ala Pro Trp Cys Pro Asp Tyr

195 200 205

Ser Ile Leu Ser Phe Met Gly Ser Phe His Gly Arg Thr Met Gly Cys

210 215 220

Leu Ala Thr Thr His Ser Lys Ala Ile His Lys Ile Asp Ile Pro Ser

225 230 235 240

Phe Asp Trp Pro Ile Ala Pro Phe Pro Arg Leu Lys Tyr Pro Leu Glu

245 250 255

Glu Phe Val Lys Glu Asn Gln Gln Glu Glu Ala Gly Cys Leu Glu Glu

260 265 270

Val Glu Asp Leu Ile Val Lys Tyr Arg Lys Lys Lys Lys Thr Val Ala

275 280 285

Gly Ile Ile Val Glu Pro Ile Gln Ser Glu Gly Gly Asp Asn His Ala

290 295 300

Ser Asp Asp Phe Phe Arg Lys Leu Arg Asp Ile Ala Arg Lys His Cys

305 310 315 320

Cys Ala Phe Leu Val Asp Glu Val Gln Thr Gly Gly Gly Cys Thr Gly

325 330 335

Lys Phe Trp Ala His Glu His Trp Gly Leu Asp Asp Pro Ala Asp Val

340 345 350

Met Thr Phe Ser Lys Lys Met Met Thr Gly Gly Phe Phe Leu Lys Glu

355 360 365

Glu Phe Arg Pro Asn Ala Pro Tyr Arg Ile Phe Asn Thr Trp Leu Gly

370 375 380

Asp Pro Ser Lys Asn Leu Leu Leu Ala Glu Val Ile Asn Ile Ile Lys

385 390 395 400

Arg Glu Asp Leu Leu Asn Asn Ala Ala His Ala Gly Lys Ala Leu Leu

405 410 415

Thr Gly Leu Leu Asp Leu Gln Ala Arg Tyr Pro Gln Phe Ile Ser Arg

420 425 430

Val Arg Gly Arg Gly Thr Phe Cys Ser Phe Asp Thr Pro Asp Asp Ser

435 440 445

Ile Arg Asn Lys Leu Ile Leu Ile Ala Arg Asn Lys Gly Val Val Leu

450 455 460

Gly Gly Cys Gly Asp Lys Ser Ile Arg Phe Arg Pro Thr Leu Val Phe

465 470 475 480

Arg Asp His His Ala His Leu Phe Leu Asn Ile Phe Ser Asp Ile Leu

485 490 495

Ala Asp Phe Lys

500

<210>97

<211>423

<212>PRT

<213> Human (Homo sapiens)

<220>

<221> Mitochondrial glycine amidinyltransferase precursor

<222>(1)..(423)

<223> August 29, 2003 Registration Number: P50440

<400>97

Met Leu Arg Val Arg Cys Leu Arg Gly Gly Ser Arg Gly Ala Glu Ala

1 5 10 15

Val His Tyr Ile Gly Ser Arg Leu Gly Arg Thr Leu Thr Gly Trp Val

20 25 30

Gln Arg Thr Phe Gln Ser Thr Gln Ala Ala Thr Ala Ser Ser Arg Asn

35 40 45

Ser Cys Ala Ala Asp Asp Lys Ala Thr Glu Pro Leu Pro Lys Asp Cys

50 55 60

Pro Val Ser Ser Tyr Asn Glu Trp Asp Pro Leu Glu Glu Val Ile Val

65 70 75 80

Gly Arg Ala Glu Asn Ala Cys Val Pro Pro Phe Thr Ile Glu Val Lys

85 90 95

Ala Asn Thr Tyr Glu Lys Tyr Trp Pro Phe Tyr Gln Lys Gln Gly Gly

100 105 110

His Tyr Phe Pro Lys Asp His Leu Lys Lys Ala Val Ala Glu Ile Glu

115 120 125

Glu Met Cys Asn Ile Leu Lys Thr Glu Gly Val Thr Val Arg Arg Pro

130 135 140

Asp Pro Ile Asp Trp Ser Leu Lys Tyr Lys Thr Pro Asp Phe Glu Ser

145 150 155 160

Thr Gly Leu Tyr Ser Ala Met Pro Arg Asp Ile Leu Ile Val Val Gly

165 170 175

Asn Glu Ile Ile Glu Ala Pro Met Ala Trp Arg Ser Arg Phe Phe Glu

180 185 190

Tyr Arg Ala Tyr Arg Ser Ile Ile Lys Asp Tyr Phe His Arg Gly Ala

195 200 205

Lys Trp Thr Thr Ala Pro Lys Pro Thr Met Ala Asp Glu Leu Tyr Asn

210 215 220

Gln Asp Tyr Pro Ile His Ser Val Glu Asp Arg His Lys Leu Ala Ala

225 230 235 240

Gln Gly Lys Phe Val Thr Thr Glu Phe Glu Pro Cys Phe Asp Ala Ala

245 250 255

Asp Phe Ile Arg Ala Gly Arg Asp Ile Phe Ala Gln Arg Ser Gln Val

260 265 270

Thr Asn Tyr Leu Gly Ile Glu Trp Met Arg Arg His Leu Ala Pro Asp

275 280 285

Tyr Arg Val His Ile Ile Ser Phe Lys Asp Pro Asn Pro Met His Ile

290 295 300

Asp Ala Thr Phe Asn Ile Ile Gly Pro Gly Ile Val Leu Ser Asn Pro

305 310 315 320

Asp Arg Pro Cys His Gln Ile Asp Leu Phe Lys Lys Ala Gly Trp Thr

325 330 335

Ile Ile Thr Pro Pro Thr Pro lle Ile Pro Asp Asp His Pro Leu Trp

340 345 350

Met Ser Ser Lys Trp Leu Ser Met Asn Val Leu Met Leu Asp Glu Lys

355 360 365

Arg Val Met Val Asp Ala Asn Glu Val Pro Ile Gln Lys Met Phe Glu

370 375 380

Lys Leu Gly Ile Thr Thr Ile Lys Val Asn Ile Arg Asn Ala Asn Ser

385 390 395 400

Leu Gly Gly Gly Phe His Cys Trp Thr Cys Asp Val Arg Arg Arg Gly

405 410 415

Thr Leu Gln Ser Tyr Leu Asp

420

<210>98

<211>654

<212>PRT

<213> Human (Homo sapiens)

<220>

<221>GRP 78

<222>(1)..(654)

<223> August 29, 2003 Registration number: P11021

<220>

<221>misc_feature

<222>(302)..(302)

<223> Xaa can be any naturally occurring amino acid

<220>

<221>misc_feature

<222>(329)..(329)

<223> Xaa can be any naturally occurring amino acid

<220>

<221>misc_feature

<222>(344)..(344)

<223> Xaa can be any naturally occurring amino acid

<220>

<221>misc_feature

<222>(461)..(461)

<223> Xaa can be any naturally occurring amino acid

<400>98

Met Lys Leu Ser Leu Val Ala Ala Met Leu Leu Leu Leu Leu Ser Ala

1 5 10 15

Ala Arg Ala Lys Glu Glu Asp Met Gly Thr Val Val Ala Ile His Leu

20 25 30

Gly Thr Thr Tyr Pro Cys Val Gly Val Phe Lys Asn Gly Arg Met Glu

35 40 45

Ile Ile Ala Asn Asp Gln Gly Asn Arg Ile Met Pro Ser Tyr Val Ala

50 55 60

Phe Thr Pro Glu Gly Glu Cys Leu Ile Gly Asp Ala Ala Lys Asn Gln

65 70 75 80

Leu Thr Ser Asn Pro Lys Asn Thr Val Phe Asp Ala Lys Arg Leu Ile

85 90 95

Gly Arg Arg Trp His Asp Pro Ser Val Gln Gln Asp Ile Glu Phe Leu

100 105 110

Pro Phe Lys Val Val Glu Lys Asn Thr Lys Ser Tyr Ile Gln Ile Asp

115 120 125

Val Gly Gly Gly Gln Thr Lys Thr Phe Ala Pro Lys Glu Ile Ser Ala

130 135 140

Met Val Leu Thr Lys Met Lys Glu Asn Ala Glu Ala Tyr Leu Gly Lys

145 150 155 160

Val Thr His Ala Val Val Thr Ala Pro Ala Tyr Phe Asn Asp Ala Gln

165 170 175

Cys Gln Ala Thr Lys Asp Ala Gly Thr Ile Ala Asp Leu Asn Val Met

180 185 190

Arg Ile Ile Asn Lys Pro Thr Ala Ala Ala Ile Ala Tyr Gly Leu Asp

195 200 205

Lys Arg Glu Gly Glu Lys Asn Ile Leu Val Phe Asp Leu Gly Gly Gly

210 215 220

Thr Phe Asp Val Ser Leu Leu Thr Ile Asp Asn Gly Val Phe Lys Val

225 230 235 240

Val Ala Thr Asn Gly Asp Thr Tyr Leu Gly Gly Glu Asp Phe Asp Gln

245 250 255

Arg Val Met Glu His Phe Ile Lys Leu Tyr Lys Lys Lys Thr Gly Lys

260 265 270

Asp Val Arg Lys Asp Asn Arg Ala Val Gln Lys Leu Trp Arg Lys Val

275 280 285

Glu Lys Ala Lys Arg Ala Leu Ser Ser Gln His Gln Ala Xaa Val Ile

290 295 300

Glu Ile Glu Ser Phe Tyr Glu Gly Glu Asp Phe Ser Glu Thr Leu Thr

305 310 315 320

Gln Ala Lys Phe Glu Glu Leu Asn Xaa Asp Leu Phe Gln Ser Thr Met

325 330 335

Lys Pro Ser Gln Arg Ser Val Xaa Lys Val Leu Glu Asp Ser Asp Leu

340 345 350

Lys Lys Ser Asp Ile Asp Glu Thr Val Leu Val Gly Gly Phe Thr Gln

355 360 365

Ile Pro Lys Ile Gln Gln Leu Val Lys Glu Phe Phe Asn Gly Lys Glu

370 375 380

Leu Ser Arg Gly Ile Ser Pro Tyr Glu Ala Val Ala Tyr Gly Ala Ala

385 390 395 400

Val Gln Ala Gly Val Leu Ser Gly Asp Gln Asp Thr Gly Asp Leu Val

405 410 415

Leu Leu Asp Ile Cys Pro Leu Thr Leu Gly Ile Glu Thr Val Gly Gly

420 425 430

Val Met Thr Lys Leu Ile Pro Arg Asn Thr Val Val Pro Thr Lys Lys

435 440 445

Ser Gln Ile Phe Ser Thr Ala Phe Asp Asn Gln Pro Xaa Thr Ile Lys

450 455 460

Val Tyr Glu Gly Lys Gln Pro Leu Thr Lys Asp Asn His Leu Leu Gly

465 470 475 480

Thr Phe Asp Leu Thr Gly Ile Pro Pro Ala Pro Cys Gly Val Pro Gln

485 490 495

Ile Glu Val Thr Phe Glu Met Asp Val Ser Asp Ile Leu Gln Val Thr

500 505 510

Ala Lys Asp Lys Gly Thr Arg Tyr Lys Asn Lys Ile Thr Ile Thr Asn

515 520 525

Asp Gln Asn His Leu Thr Pro Glu Asp Ile Glu Arg Met Val Asn Asp

530 535 540

Ala Glu Lys Phe Ala Glu Glu Asp Lys Lys Leu Lys Glu Cys Thr Asp

545 550 555 560

Thr Arg Asn Glu Leu Glu Ser Tyr Ala Tyr Ser Leu Lys Asn Gln Ile

565 570 575

Gly Asp Lys Glu Lys Leu Gly Gly Lys Leu Ser Ser Glu Asp Lys Glu

580 585 590

Thr Met Glu Lys Thr Val Glu Glu Lys Thr Glu Trp Leu Glu Ser His

595 600 605

Gln Asp Ala Asp Thr Glu Asp Phe Lys Ala Lys Lys Lys Glu Leu Glu

610 615 620

Glu Ile Val Gln Pro Ile Ile Ser Lys Leu Tyr Gly Ser Ala Gly Pro

625 630 635 640

Pro Pro Thr Gly Glu Glu Asp Thr Ala Glu Lys Asp Glu Leu

645 650

<210>99

<211>325

<212>PRT

<213> Human (Homo sapiens)

<220>

<221> Eukaryotic translation initiation factor 3 subunit-2

<222>(1)..(325)

<223> August 29, 2003 Registration number: Q13347

<400>99

Met Lys Pro Ile Leu Leu Gln Gly His Glu Arg Ser Ile Thr Gln Ile

1 5 10 15

Lys Tyr Asn Arg Glu Gly Asp Leu Leu Phe Thr Val Ala Lys Asp Pro

20 25 30

Ile Val Asn Val Trp Tyr Ser Val Asn Gly Glu Arg Leu Gly Thr Tyr

35 40 45

Met Gly His Thr Gly Ala Val Trp Cys Val Asp Ala Asp Trp Asp Thr

50 55 60

Lys His Val Leu Thr Gly Ser Ala Asp Asn Ser Cys Arg Leu Trp Asp

65 70 75 80

Cys Glu Thr Gly Lys Gln Leu Ala Leu Leu Lys Thr Asn Ser Ala Val

85 90 95

Arg Thr Cys Gly Phe Asp Phe Gly Gly Asn Ile Ile Met Phe Ser Thr

100 105 110

Asp Lys Gln Met Gly Tyr Gln Cys Phe Val Ser Phe Phe Asp Leu Arg

115 120 125

Asp Pro Ser Gln Ile Asp Asn Asn Glu Pro Tyr Met Lys Ile Pro Cys

130 135 140

Asn Asp Ser Lys Ile Thr Ser Ala Val Trp Gly Pro Leu Gly Glu Cys

145 150 155 160

Ile Ile Ala Gly His Glu Ser Gly Glu Leu Asn Gln Tyr Ser Ala Lys

165 170 175

Ser Gly Glu Val Leu Val Asn Val Lys Glu His Ser Arg Gln Ile Asn

180 185 190

Asp Ile Gln Leu Ser Arg Asp Met Thr Met Phe Val Thr Ala Ser Lys

195 200 205

Asp Asn Thr Ala Lys Leu Phe Asp Ser Thr Thr Leu Glu His Gln Lys

210 215 220

Thr Phe Arg Thr Glu Arg Pro Val Asn Ser Ala Ala Leu Ser Pro Asn

225 230 235 240

Tyr Asp His Val Val Leu Gly Gly Gly Gln Glu Ala Met Asp Val Thr

245 250 255

Thr Thr Ser Thr Arg Ile Gly Lys Phe Glu Ala Arg Phe Phe His Leu

260 265 270

Ala Phe Glu Glu Glu Phe Gly Arg Val Lys Gly His Phe Gly Pro Ile

275 280 285

Asn Ser Val Ala Phe His Pro Asp Gly Lys Ser Tyr Ser Ser Gly Gly

290 295 300

Glu Asp Gly Tyr Val Arg Ile His Tyr Phe Asp Pro Gln Tyr Phe Glu

305 310 315 320

Phe Glu Phe Glu Ala

325

<210>100

<211>572

<212>PRT

<213> Human (Homo sapiens)

<220>

<221> dihydropyrimidinase-related protein 2

<222>(1)..(572)

<223> August 29, 2003 Registration number: Q16555

<400>100

Met Ser Tyr Gln Gly Lys Lys Asn Ile Pro Arg Ile Thr Ser Asp Arg

1 5 10 15

Leu Leu Ile Lys Gly Gly Lys Ile Val Asn Asp Asp Gln Ser Phe Tyr

20 25 30

Ala Asp Ile Tyr Met Glu Asp Gly Leu Ile Lys Gln Ile Gly Glu Asn

35 40 45

Leu Ile Val Pro Gly Gly Val Lys Thr Ile Glu Ala His Ser Arg Met

50 55 60

Val Ile Pro Gly Gly Ile Asp Val His Thr Arg Phe Gln Met Pro Asp

65 70 75 80

Gln Gly Met Thr Ser Ala Asp Asp Phe Phe Gln Gly Thr Lys Ala Ala

85 90 95

Leu Ala Gly Gly Thr Thr Met Ile Ile Asp His Val Val Pro Glu Pro

100 105 110

Gly Thr Ser Leu Leu Ala Ala Phe Asp Gln Trp Arg Glu Trp Ala Asp

115 120 125

Ser Lys Ser Cys Cys Asp Tyr Ser Leu His Val Asp Ile Ser Glu Trp

130 135 140

His Lys Gly Ile Gln Glu Glu Met Glu Ala Leu Val Lys Asp His Gly

145 150 155 160

Val Asn Ser Phe Leu Val Tyr Met Ala Phe Lys Asp Arg Phe Gln Leu

165 170 175

Thr Asp Cys Gln Ile Tyr Glu Val Leu Ser Val Ile Arg Asp Ile Gly

180 185 190

Ala Ile Ala Gln Val His Ala Glu Asn Gly Asp Ile Ile Ala Glu Glu

195 200 205

Gln Gln Arg Ile Leu Asp Leu Gly Ile Thr Gly Pro Glu Gly His Val

210 215 220

Leu Ser Arg Pro Glu Glu Val Glu Ala Glu Ala Val Asn Arg Ala Ile

225 230 235 240

Thr Ile Ala Asn Gln Thr Asn Cys Pro Leu Tyr Ile Thr Lys Val Met

245 250 255

Ser Lys Ser Ser Ala Glu Val Ile Ala Gln Ala Arg Lys Lys Gly Thr

260 265 270

Val Val Tyr Gly Glu Pro Ile Thr Ala Ser Leu Gly Thr Asp Gly Ser

275 280 285

His Tyr Trp Ser Lys Asn Trp Ala Lys Ala Ala Ala Phe Val Thr Ser

290 295 300

Pro Pro Leu Ser Pro Asp Pro Thr Thr Pro Asp Phe Leu Asn Ser Leu

305 310 315 320

Leu Ser Cys Gly Asp Leu Gln Val Thr Gly Ser Ala His Cys Thr Phe

325 330 335

Asn Thr Ala Gln Lys Ala Val Gly Lys Asp Asn Phe Thr Leu Ile Pro

340 345 350

Glu Gly Thr Asn Gly Thr Glu Glu Arg Met Ser Val Ile Trp Asp Lys

355 360 365

Ala Val Val Thr Gly Lys Met Asp Glu Asn Gln Phe Val Ala Val Thr

370 375 380

Ser Thr Asn Ala Ala Lys Val Phe Asn Leu Tyr Pro Arg Lys Gly Arg

385 390 395 400

Ile Ala Val Gly Ser Asp Ala Asp Leu Val Ile Trp Asp Pro Asp Ser

405 410 415

Val Lys Thr Ile Ser Ala Lys Thr His Asn Ser Ser Leu Glu Tyr Asn

420 425 430

Ile Phe Glu Gly Met Glu Cys Arg Gly Ser Pro Leu Val Val Ile Ser

435 440 445

Gln Gly Lys Ile Val Leu Glu Asp Gly Thr Leu His Val Thr Glu Gly

450 455 460

Ser Gly Arg Tyr Ile Pro Arg Lys Pro Phe Pro Asp Phe Val Tyr Lys

465 470 475 480

Arg Ile Lys Ala Arg Ser Arg Leu Ala Glu Leu Arg Gly Val Pro Arg

485 490 495

Gly Leu Tyr Asp Gly Pro Val Cys Glu Val Ser Val Thr Pro Lys Thr

500 505 510

Val Thr Pro Ala Ser Ser Ala Lys Thr Ser Pro Ala Lys Gln Gln Ala

515 520 525

Pro Pro Val Arg Asn Leu His Gln Ser Gly Phe Ser Leu Ser Gly Ala

530 535 540

Gln Ile Asp Asp Asn Ile Pro Arg Arg Thr Thr Gln Arg Ile Val Ala

545 550 555 560

Pro Pro Gly Gly Arg Ala Asn Ile Thr Ser Leu Gly

565 570

<210>101

<211>561

<212>PRT

<213> Human (Homo sapiens)

<220>

<221> Phosphoglucomutase (EC 5.4.2.2) (PGM)

<222>(1)..(561)

<223> August 29, 2003 Registration number: P36871

<400>101

Val Lys Ile Val Thr Val Lys Thr Gln Ala Tyr Gln Asp Gln Lys Pro

1 5 10 15

Gly Thr Ser Gly Leu Arg Lys Arg Val Lys Val Phe Gln Ser Ser Ala

20 25 30

Asn Tyr Ala Glu Asn Phe Ile Gln Ser Ile Ile Ser Thr Val Glu Pro

35 40 45

Ala Gln Arg Gln Glu Ala Thr Leu Val Val Gly Gly Asp Gly Arg Phe

50 55 60

Tyr Met Lys Glu Ala Ile Gln Leu Ile Ala Arg Ile Ala Ala Ala Asn

65 70 75 80

Gly Ile Gly Arg Leu Val Ile Gly Gln Asn Gly Ile Leu Ser Thr Pro

85 90 95

Ala Val Ser Cys Ile Ile Arg Lys Ile Lys Ala Ile Gly Gly Ile Ile

100 105 110

Leu Thr Ala Ser His Asn Pro Gly Gly Pro Asn Gly Asp Phe Gly Ile

115 120 125

Lys Phe Asn Ile Ser Asn Gly Gly Pro Ala Pro Glu Ala Ile Thr Asp

130 135 140

Lys Ile Phe Gln Ile Ser Lys Thr Ile Glu Glu Tyr Ala Val Cys Pro

145 150 155 160

Asp Leu Lys Val Asp Leu Gly Val Leu Gly Lys Gln Gln Phe Asp Leu

165 170 175

Glu Asn Lys Phe Lys Pro Phe Thr Val Glu Ile Val Asp Ser Val Glu

180 185 190

Ala Tyr Ala Thr Met Leu Arg Ser Ile Phe Asp Phe Ser Ala Leu Lys

195 200 205

Glu Leu Leu Ser Gly Pro Asn Arg Leu Lys Ile Arg Ile Asp Ala Met

210 215 220

His Gly Val Val Gly Pro Tyr Val Lys Lys Ile Leu Cys Glu Glu Leu

225 230 235 240

Gly Ala Pro Ala Asn Ser Ala Val Asn Cys Val Pro Leu Glu Asp Phe

245 250 255

Gly Gly His His Pro Asp Pro Asn Leu Thr Tyr Ala Ala Asp Leu Val

260 265 270

Glu Thr Met Lys Ser Gly Glu His Asp Phe Gly Ala Ala Phe Asp Gly

275 280 285

Asp Gly Asp Arg Asn Met Ile Leu Gly Lys His Gly Phe Phe Val Asn

290 295 300

Pro Ser Asp Ser Val Ala Val Ile Ala Ala Asn Ile Phe Ser Ile Pro

305 310 315 320

Tyr Phe Gln Gln Thr Gly Val Arg Gly Phe Ala Arg Ser Met Pro Thr

325 330 335

Ser Gly Ala Leu Asp Arg Val Ala Ser Ala Thr Lys Ile Ala Leu Tyr

340 345 350

Glu Thr Pro Thr Gly Trp Lys Phe Phe Gly Asn Leu Met Asp Ala Ser

355 360 365

Lys Leu Ser Leu Cys Gly Glu Glu Ser Phe Gly Thr Gly Ser Asp His

370 375 380

Ile Arg Glu Lys Asp Gly Leu Trp Ala Val Leu Ala Trp Leu Ser Ile

385 390 395 400

Leu Ala Thr Arg Lys Gln Ser Val Glu Asp Ile Leu Lys Asp His Trp

405 410 415

Gln Lys Tyr Gly Arg Asn Phe Phe Thr Arg Tyr Asp Tyr Glu Glu Val

420 425 430

Glu Ala Glu Gly Ala Asn Lys Met Met Lys Asp Leu Glu Ala Leu Met

435 440 445

Phe Asp Arg Ser Phe Val Gly Lys Gln Phe Ser Ala Asn Asp Lys Val

450 455 460

Tyr Thr Val Glu Lys Ala Asp Asn Phe Glu Tyr Ser Asp Pro Val Asp

465 470 475 480

Gly Ser Ile Ser Arg Asn Gln Gly Leu Arg Leu Ile Phe Thr Asp Gly

485 490 495

Ser Arg Ile Val Phe Arg Leu Ser Gly Thr Gly Ser Ala Gly Ala Thr

500 505 510

Ile Arg Leu Tyr Ile Asp Ser Tyr Glu Lys Asp Val Ala Lys Ile Asn

515 520 525

Gln Asp Pro Gln Val Met Leu Ala Pro Leu Ile Ser Ile Ala Leu Lys

530 535 540

Val Ser Gln Leu Gln Glu Arg Thr Gly Arg Thr Ala Pro Thr Val Ile

545 550 555 560

Thr

<210>102

<211>263

<212>PRT

<213> Human (Homo sapiens)

<220>

<221> Proteasome subunit Alpha-1 type

<222>(1)..(263)

<223> August 29, 2003 Registration number: P25786

<400>102

Met Phe Arg Asn Gln Tyr Asp Asn Asp Val Thr Val Trp Ser Pro Gln

1 5 10 15

Gly Arg Ile His Gln Ile Glu Tyr Ala Met Glu Ala Val Lys Gln Gly

20 25 30

Ser Ala Thr Val Gly Leu Lys Ser Lys Thr His Ala Val Leu Val Ala

35 40 45

Leu Lys Arg Ala Gln Ser Glu Leu Ala Ala His Gln Lys Lys Ile Leu

50 55 60

His Val Asp Asn His Ile Gly Ile Ser Ile Ala Gly Leu Thr Ala Asp

65 70 75 80

Ala Arg Leu Leu Cys Asn Phe Met Arg Gln Glu Cys Leu Asp Ser Arg

85 90 95

Phe Val Phe Asp Arg Pro Leu Pro Val Ser Arg Leu Val Ser Leu Ile

100 105 110

Gly Ser Lys Thr Gln Ile Pro Thr Gln Arg Tyr Gly Arg Arg Pro Tyr

115 120 125

Gly Val Gly Leu Leu Ile Ala Gly Tyr Asp Asp Met Gly Pro His Ile

130 135 140

Phe Gln Thr Cys Pro Ser Ala Asn Tyr Phe Asp Cys Arg Ala Met Ser

145 150 155 160

Ile Gly Ala Arg Ser Gln Ser Ala Arg Thr Tyr Leu Glu Arg His Met

165 170 175

Ser Glu Phe Met Glu Cys Asn Leu Asn Glu Leu Val Lys His Gly Leu

180 185 190

Arg Ala Leu Arg Glu Thr Leu Pro Ala Glu Gln Asp Leu Thr Thr Lys

195 200 205

Asn Val Ser Ile Gly Ile Val Gly Lys Asp Leu Glu Phe Thr Ile Tyr

210 215 220

Asp Asp Asp Asp Val Ser Pro Phe Leu Glu Gly Leu Glu Glu Arg Pro

225 230 235 240

Gln Arg Lys Ala Gln Pro Ala Gln Pro Ala Asp Glu Pro Ala Glu Lys

245 250 255

Ala Asp Glu Pro Met Glu His

260

<210>103

<211>205

<212>PRT

<213> Human (Homo sapiens)

<220>

<221> heat shock 27kDa protein

<222>(1)..(205)

<223> August 29, 2003 Registration Number: P04792

<400>103

Met Thr Glu Arg Arg Val Pro Phe Ser Leu Leu Arg Gly Pro Ser Trp

1 5 10 15

Asp Pro Phe Arg Asp Trp Tyr Pro His Ser Arg Leu Phe Asp Gln Ala

20 25 30

Phe Gly Leu Pro Arg Leu Pro Glu Glu Trp Ser Gln Trp Leu Gly Gly

35 40 45

Ser Ser Trp Pro Gly Tyr Val Arg Pro Leu Pro Pro Ala Ala Ile Glu

50 55 60

Ser Pro Ala Val Ala Ala Pro Ala Tyr Ser Arg Ala Leu Ser Arg Gln

65 70 75 80

Leu Ser Ser Gly Val Ser Glu Ile Arg His Thr Ala Asp Arg Trp Arg

85 90 95

Val Ser Leu Asp Val Asn His Phe Ala Pro Asp Glu Leu Thr Val Lys

100 105 110

Thr Lys Asp Gly Val Val Glu Ile Thr Gly Lys His Glu Glu Arg Gln

115 120 125

Asp Glu His Gly Tyr Ile Ser Arg Cys Phe Thr Arg Lys Tyr Thr Leu

130 135 140

Pro Pro Gly Val Asp Pro Thr Gln Val Ser Ser Ser Leu Ser Pro Glu

145 150 155 160

Gly Thr Leu Thr Val Glu Ala Pro Met Pro Lys Leu Ala Thr Gln Ser

165 170 175

Asn Glu Ile Thr Ile Pro Val Thr Phe Glu Ser Arg Ala Gln Leu Gly

180 185 190

Gly Pro Glu Ala Ala Lys Ser Asp Glu Thr Ala Ala Lys

195 200 205

<210>104

<211>868

<212>PRT

<213> Human (Homo sapiens)

<220>

<221> Apoptosis 6 interacting protein (Hp95)

<222>(1)..(868)

<223> August 29, 2003 Registration number: Q8WUM4

<400>104

Met Ala Thr Phe Ile Ser Val Gln Leu Lys Lys Thr Ser Glu Val Asp

1 5 10 15

Leu Ala Lys Pro Leu Val Lys Phe Ile Gln Gln Thr Tyr Pro Ser Gly

20 25 30

Gly Glu Glu Gln Ala Gln Tyr Cys Arg Ala Ala Glu Glu Leu Ser Lys

35 40 45

Leu Arg Arg Ala Ala Val Gly Arg Pro Leu Asp Lys His Glu Gly Ala

50 55 60

Leu Glu Thr Leu Leu Arg Tyr Tyr Asp Gln Ile Cys Ser Ile Glu Pro

65 70 75 80

Lys Phe Pro Phe Ser Glu Asn Gln Ile Cys Leu Thr Phe Thr Trp Lys

85 90 95

Asp Ala Phe Asp Lys Gly Ser Leu Phe Gly Gly Ser Val Lys Leu Ala

100 105 110

Leu Ala Ser Leu Gly Tyr Glu Lys Ser Cys Val Leu Phe Asn Cys Ala

115 120 125

Ala Leu Ala Ser Gln Ile Ala Ala Glu Gln Asn Leu Asp Asn Asp Glu

130 135 140

Gly Leu Lys Ile Ala Ala Lys His Tyr Gln Phe Ala Ser Gly Ala Phe

145 150 155 160

Leu His Ile Lys Glu Thr Val Leu Ser Ala Leu Ser Arg Glu Pro Thr

165 170 175

Val Asp Ile Ser Pro Asp Thr Val Gly Thr Leu Ser Leu Ile Met Leu

180 185 190

Ala Gln Ala Gln Glu Val Phe Phe Leu Lys Ala Thr Arg Asp Lys Met

195 200 205

Lys Asp Ala Ile Ile Ala Lys Leu Ala Asn Gln Ala Ala Asp Tyr Phe

210 215 220

Gly Asp Ala Phe Lys Gln Cys Gln Tyr Lys Asp Thr Leu Pro Lys Glu

225 230 235 240

Val Phe Pro Val Leu Ala Ala Lys His Cys Ile Met Gln Ala Asn Ala

245 250 255

Glu Tyr His Gln Ser Ile Leu Ala Lys Gln Gln Lys Lys Phe Gly Glu

260 265 270

Glu Ile Ala Arg Leu Gln His Ala Ala Glu Leu Ile Lys Thr Val Ala

275 280 285

Ser Arg Tyr Asp Glu Tyr Val Asn Val Lys Asp Phe Ser Asp Lys Ile

290 295 300

Asn Arg Ala Leu Ala Ala Ala Lys Lys Asp Asn Asp Phe Ile Tyr His

305 310 315 320

Asp Arg Val Pro Asp Leu Lys Asp Leu Asp Pro Ile Gly Lys Ala Thr

325 330 335

Leu Val Lys Ser Thr Pro Val Asn Val Pro Ile Ser Gln Lys Phe Thr

340 345 350

Asp Leu Phe Glu Lys Met Val Pro Val Ser Val Gln Gln Ser Leu Ala

355 360 365

Ala Tyr Asn Gln Arg Lys Ala Asp Leu Val Asn Arg Ser Ile Ala Gln

370 375 380

Met Arg Glu Ala Thr Thr Leu Ala Asn Gly Val Leu Ala Ser Leu Asn

385 390 395 400

Leu Pro Ala Ala Ile Glu Asp Val Ser Gly Asp Thr Val Pro Gln Ser

405 410 415

Ile Leu Thr Lys Ser Arg Ser Val Ile Glu Gln Gly Gly Ile Gln Thr

420 425 430

Val Asp Gln Leu Ile Lys Glu Leu Pro Glu Leu Leu Gln Arg Asn Arg

435 440 445

Glu Ile Leu Asp Glu Ser Leu Arg Leu Leu Asp Glu Glu Glu Ala Thr

450 455 460

Asp Asn Asp Leu Arg Ala Lys Phe Lys Glu Arg Trp Gln Arg Thr Pro

465 470 475 480

Ser Asn Glu Leu Tyr Lys Pro Leu Arg Ala Glu Gly Thr Asn Phe Arg

485 490 495

Thr Val Leu Asp Lys Ala Val Gln Ala Asp Gly Gln Val Lys Glu Cys

500 505 510

Tyr Gln Ser His Arg Asp Thr Ile Val Leu Leu Cys Lys Pro Glu Pro

515 520 525

Glu Leu Asn Ala Ala Ile Pro Ser Ala Asn Pro Ala Lys Thr Met Gln

530 535 540

Gly Ser Glu Val Val Asn Val Leu Lys Ser Leu Leu Ser Asn Leu Asp

545 550 555 560

Glu Val Lys Lys Glu Arg Glu Gly Leu Glu Asn Asp Leu Lys Ser Val

565 570 575

Asn Phe Asp Met Thr Ser Lys Phe Leu Thr Ala Leu Ala Gln Asp Gly

580 585 590

Val Ile Asn Glu Glu Ala Leu Ser Val Thr Glu Leu Asp Arg Val Tyr

595 600 605

Gly Gly Leu Thr Thr Lys Val Gln Glu Ser Leu Lys Lys Gln Glu Gly

610 615 620

Leu Leu Lys Asn Ile Gln Val Ser His Gln Glu Phe Ser Lys Met Lys

625 630 635 640

Gln Ser Asn Asn Glu Ala Asn Leu Arg Glu Glu Val Leu Lys Asn Leu

645 650 655

Ala Thr Ala Tyr Asp Asn Phe Val Glu Leu Val Ala Asn Leu Lys Glu

660 665 670

Gly Thr Lys Phe Tyr Asn Glu Leu Thr Glu Ile Leu Val Arg Phe Gln

675 680 685

Asn Lys Cys Ser Asp Ile Val Phe Ala Arg Lys Thr Glu Arg Asp Glu

690 695 700

Leu Leu Lys Asp Leu Gln Gln Ser Ile Ala Arg Glu Pro Ser Ala Pro

705 710 715 720

Ser Ile Pro Thr Pro Ala Tyr Gln Ser Ser Pro Ala Gly Gly His Ala

725 730 735

Pro Thr Pro Pro Thr Pro Ala Pro Arg Thr Met Pro Pro Thr Lys Pro

740 745 750

Gln Pro Pro Ala Arg Pro Pro Pro Pro Pro Val Leu Pro Ala Asn Arg Ala

755 760 765

Pro Ser Ala Thr Ala Pro Ser Pro Val Gly Ala Gly Thr Ala Ala Pro

770 775 780

Ala Pro Ser Gln Thr Pro Gly Ser Ala Pro Pro Pro Gln Ala Gln Gly

785 790 795 800

Pro Pro Tyr Pro Thr Tyr Pro Gly Tyr Pro Gly Tyr Cys Gln Met Pro

805 810 815

Met Pro Met Gly Tyr Asn Pro Tyr Ala Tyr Gly Gln Tyr Asn Met Pro

820 825 830

Tyr Pro Pro Val Tyr His Gln Ser Pro Gly Gln Ala Pro Tyr Pro Gly

835 840 845

Pro Gln Gln Pro Ser Tyr Pro Phe Pro Gln Pro Pro Gln Gln Ser Tyr

850 855 860

Tyr Pro Gln Gln

865

<210>105

<211>280

<212>PRT

<213> Human (Homo sapiens)

<220>

<221> similar to 4.5 LIM domain 3

<222>(1)..(280)

<223> August 29, 2003 Registration number: Q9BVA2

<400>105

Met Ser Glu Ser Phe Asp Cys Ala Lys Cys Asn Glu Ser Leu Tyr Gly

1 5 10 15

Arg Lys Tyr Ile Gln Thr Asp Ser Gly Pro Tyr Cys Val Pro Cys Tyr

20 25 30

Asp Asn Thr Phe Ala Asn Thr Cys Ala Glu Cys Gln Gln Leu Ile Gly

35 40 45

His Asp Ser Arg Glu Leu Phe Tyr Glu Asp Arg His Phe His Glu Gly

50 55 60

Cys Phe Arg Cys Cys Arg Cys Gln Arg Ser Leu Ala Asp Glu Pro Phe

65 70 75 80

Thr Cys Gln Asp Ser Glu Leu Leu Cys Asn Asp Cys Tyr Cys Ser Ala

85 90 95

Phe Ser Ser Gln Cys Ser Ala Cys Gly Glu Thr Val Met Pro Gly Ser

100 105 110

Arg Lys Leu Glu Tyr Gly Gly Gln Thr Trp His Glu His Cys Phe Leu

115 120 125

Cys Ser Gly Cys Glu Gln Pro Leu Gly Ser Arg Ser Phe Val Pro Asp

130 135 140

Lys Gly Ala His Tyr Cys Val Pro Cys Tyr Glu Asn Lys Phe Ala Pro

145 150 155 160

Arg Cys Ala Arg Cys Ser Lys Thr Leu Thr Gln Gly Gly Val Thr Tyr

165 170 175

Arg Asp Gln Pro Trp His Arg Glu Cys Leu Val Cys Thr Gly Cys Gln

180 185 190

Thr Pro Leu Ala Gly Gln Gln Phe Thr Ser Arg Asp Glu Asp Pro Tyr

195 200 205

Cys Val Ala Cys Phe Gly Glu Leu Phe Ala Pro Lys Cys Ser Ser Cys

210 215 220

Lys Arg Pro Ile Val Gly Leu Gly Gly Gly Lys Tyr Val Ser Phe Glu

225 230 235 240

Asp Arg His Trp His His Asn Cys Phe Ser Cys Ala Arg Cys Ser Thr

245 250 255

Ser Leu Val Gly Gln Gly Phe Val Pro Asp Gly Asp Gln Val Leu Cys

260 265 270

Gln Gly Cys Ser Gln Ala Gly Pro

275 280

<210>106

<211>280

<212>PRT

<213> Human (Homo sapiens)

<220>

<221> Skeletal muscle LIM protein 2 (SLIM 2)

<222>(1)..(280)

<223> August 29, 2003 Registration number: Q13643

<400>106

Met Ser Glu Ser Phe Asp Cys Ala Lys Cys Asn Glu Ser Leu Tyr Gly

1 5 10 15

Arg Lys Tyr Ile Gln Thr Asp Ser Gly Pro Tyr Cys Val Pro Cys Tyr

20 25 30

Asp Asn Thr Phe Ala Asn Thr Cys Ala Glu Cys Gln Gln Leu Ile Gly

35 40 45

His Asp Ser Arg Glu Leu Phe Tyr Glu Asp Arg His Phe His Glu Gly

50 55 60

Cys Phe Arg Cys Cys Arg Cys Gln Arg Ser Leu Ala Asp Glu Pro Phe

65 70 75 80

Thr Arg Gln Asp Ser Glu Leu Leu Cys Asn Asp Cys Tyr Cys Ser Ala

85 90 95

Phe Ser Ser Gln Cys Ser Ala Cys Gly Glu Thr Val Met Pro Gly Ser

100 105 110

Arg Lys Leu Glu Tyr Gly Gly Gln Thr Trp His Glu His Cys Phe Leu

115 120 125

Cys Ile Gly Cys Glu Gln Pro Leu Gly Ser Arg Pro Phe Val Pro Asp

130 135 140

Lys Gly Ala His Tyr Cys Val Pro Cys Tyr Glu Asn Asn Phe Ala Pro

145 150 155 160

Arg Cys Ala Arg Cys Thr Lys Thr Leu Thr Gln Gly Gly Leu Thr Tyr

165 170 175

Arg Asp Leu Pro Trp His Pro Lys Cys Leu Val Cys Thr Gly Cys Gln

180 185 190

Thr Pro Leu Ala Gly Gln Gln Phe Thr Ser Arg Asp Glu Asp Pro Tyr

195 200 205

Cys Val Ala Cys Phe Gly Glu Leu Phe Ala Pro Lys Cys Ser Ser Cys

210 215 220

Lys Arg Pro Ile Val Gly Leu Gly Gly Gly Lys Tyr Val Ser Phe Glu

225 230 235 240

Asp Arg His Trp His His Asn Cys Phe Thr Cys Asp Arg Cys Ser Asn

245 250 255

Ser Leu Val Gly Gln Gly Phe Val Pro Asp Gly Asp Gln Val Leu Cys

260 265 270

Gln Gly Cys Ser Gln Ala Gly Pro

275 280

<210>107

<211>133

<212>PRT

<213> Human (Homo sapiens)

<220>

<221> Cytochrome b5

<222>(1)..(133)

<223> August 29, 2003 Registration number: P00167

<400>107

Ala Glu Gln Ser Asp Glu Ala Val Lys Tyr Tyr Thr Leu Glu Glu Ile

1 5 10 15

Gln Lys His Asn His Ser Lys Ser Thr Trp Leu Ile Leu His His Lys

20 25 30

Val Tyr Asp Leu Thr Lys Phe Leu Glu Glu His Pro Gly Gly Glu Glu

35 40 45

Val Leu Arg Glu Gln Ala Gly Gly Asp Ala Thr Glu Asn Phe Glu Asp

50 55 60

Val Gly His Ser Thr Asp Ala Arg Glu Met Ser Lys Thr Phe Ile Ile

65 70 75 80

Gly Glu Leu His Pro Asp Asp Arg Pro Lys Leu Asn Lys Pro Pro Glu

85 90 95

Thr Leu Ile Thr Thr Ile Asp Ser Ser Ser Ser Trp Trp Thr Asn Trp

100 105 110

Val Ile Pro Ala Ile Ser Ala Val Ala Val Ala Leu Met Tyr Arg Leu

115 120 125

Tyr Met Ala Glu Asp

130

<210>108

<211>175

<212>PRT

<213> Human (Homo sapiens)

<220>

<221> pancreatitis-associated protein body 1 precursor

<222>(1)..(175)

<223> August 29, 2003 Registration number: Q06141

<400>108

Met Leu Pro Pro Met Ala Leu Pro Ser Val Ser Trp Met Leu Leu Ser

1 5 10 15

Cys Leu Met Leu Leu Ser Gln Val Gln Gly Glu Glu Pro Gln Arg Glu

20 25 30

Leu Pro Ser Ala Arg Ile Arg Cys Pro Lys Gly Ser Lys Ala Tyr Gly

35 40 45

Ser His Cys Tyr Ala Leu Phe Leu Ser Pro Lys Ser Trp Thr Asp Ala

50 55 60

Asp Leu Ala Cys Gln Lys Arg Pro Ser Gly Asn Leu Val Ser Val Leu

65 70 75 80

Ser Gly Ala Glu Gly Ser Phe Val Ser Ser Leu Val Lys Ser Ile Gly

85 90 95

Asn Ser Tyr Ser Tyr Val Trp Ile Gly Leu His Asp Pro Thr Gln Gly

100 105 110

Thr Glu Pro Asn Gly Glu Gly Trp Glu Trp Ser Ser Ser Asp Val Met

115 120 125

Asn Tyr Phe Ala Trp Glu Arg Asn Pro Ser Thr Ile Ser Ser Pro Gly

130 135 140

His Cys Ala Ser Leu Ser Arg Ser Thr Ala Phe Leu Arg Trp Lys Asp

145 150 155 160

Tyr Asn Cys Asn Val Arg Leu Pro Tyr Val Cys Lys Phe Thr Asp

165 170 175

<210>109

<211>1028

<212>PRT

<213> Human (Homo sapiens)

<220>

<221>Collagen Alpha-1(VI) chain precursor

<222>(1)..(1028)

<223> August 29, 2003 Registration number: P12109

<400>109

Met Arg Ala Ala Arg Ala Leu Leu Pro Leu Leu Leu Gln Ala Cys Trp

1 5 10 15

Thr Ala Ala Gln Asp Glu Pro Glu Thr Pro Arg Ala Val Ala Phe Gln

20 25 30

Asp Cys Pro Val Asp Leu Phe Phe Val Leu Asp Thr Ser Glu Ser Val

35 40 45

Ala Leu Arg Leu Lys Pro Tyr Gly Ala Leu Val Asp Lys Val Lys Ser

50 55 60

Phe Thr Lys Arg Phe Ile Asp Asn Leu Arg Asp Arg Tyr Tyr Arg Cys

65 70 75 80

Asp Arg Asn Leu Val Trp Asn Ala Gly Ala Leu His Tyr Ser Asp Glu

85 90 95

Val Glu Ile Ile Gln Gly Leu Thr Arg Met Pro Gly Gly Arg Asp Ala

100 105 110

Leu Lys Ser Ser Val Asp Ala Val Lys Tyr Phe Gly Lys Gly Thr Tyr

115 120 125

Thr Asp Cys Ala Ile Lys Lys Gly Leu Glu Gln Leu Leu Val Gly Gly

130 135 140

Ser His Leu Lys Glu Asn Lys Tyr Leu Ile Val Val Thr Asp Gly His

145 150 155 160

Pro Leu Glu Gly Tyr Lys Glu Pro Cys Gly Gly Leu Glu Asp Ala Val

165 170 175

Asn Glu Ala Lys His Leu Gly Val Lys Val Phe Ser Val Ala Ile Thr

180 185 190

Pro Asp His Leu Glu Pro Arg Leu Ser Ile Ile Ala Thr Asp His Thr

195 200 205

Tyr Arg Arg Asn Phe Thr Ala Ala Asp Trp Gly Gln Ser Arg Asp Ala

210 215 220

Glu Glu Ala Ile Ser Gln Thr Ile Asp Thr Ile Val Asp Met Ile Lys

225 230 235 240

Asn Asn Val Glu Gln Val Cys Cys Ser Phe Glu Cys Gln Pro Ala Arg

245 250 255

Gly Pro Pro Gly Leu Arg Gly Asp Pro Gly Phe Glu Gly Glu Arg Gly

260 265 270

Lys Pro Gly Leu Pro Gly Glu Lys Gly Glu Ala Gly Asp Pro Gly Arg

275 280 285

Pro Gly Asp Leu Gly Pro Val Gly Tyr Gln Gly Met Lys Gly Glu Lys

290 295 300

Gly Ser Arg Gly Glu Lys Gly Ser Arg Gly Pro Lys Gly Tyr Lys Gly

305 310 315 320

Glu Lys Gly Lys Arg Gly Ile Asp Gly Val Asp Gly Val Lys Gly Glu

325 330 335

Met Gly Tyr Pro Gly Leu Pro Gly Cys Lys Gly Ser Pro Gly Phe Asp

340 345 350

Gly Ile Gln Gly Pro Pro Gly Pro Lys Gly Asp Pro Gly Ala Phe Gly

355 360 365

Leu Lys Gly Glu Lys Gly Glu Pro Gly Ala Asp Gly Glu Ala Gly Arg

370 375 380

Pro Gly Ala Arg Gly Pro Ser Gly Asp Glu Gly Pro Ala Gly Glu Pro

385 390 395 400

Gly Pro Pro Gly Glu Lys Gly Glu Ala Gly Asp Glu Gly Asn Pro Gly

405 410 415

Pro Asp Gly Ala Pro Gly Glu Arg Gly Gly Pro Gly Glu Arg Gly Pro

420 425 430

Arg Gly Thr Pro Gly Pro Arg Gly Pro Arg Gly Asp Pro Gly Glu Ala

435 440 445

Gly Pro Gln Gly Asp Gln Gly Arg Glu Gly Pro Val Gly Val Pro Gly

450 455 460

Asp Pro Gly Glu Ala Gly Pro Ile Gly Pro Lys Gly Tyr Arg Gly Asp

465 470 475 480

Glu Gly Pro Pro Gly Ser Glu Gly Ala Arg Gly Ala Pro Gly Pro Ala

485 490 495

Gly Pro Pro Gly Asp Pro Gly Leu Met Gly Glu Arg Gly Glu Asp Gly

500 505 510

Pro Ala Gly Asn Gly Thr Glu Gly Phe Pro Gly Phe Pro Gly Tyr Pro

515 520 525

Gly Asn Arg Gly Ala Pro Gly Ile Asn Gly Thr Lys Gly Tyr Pro Gly

530 535 540

Leu Lys Gly Asp Glu Gly Glu Ala Gly Asp Pro Gly Asp Asp Asn Asn

545 550 555 560

Asp Ile Ala Pro Arg Gly Val Lys Gly Ala Lys Gly Tyr Arg Gly Pro

565 570 575

Glu Gly Pro Gln Gly Pro Pro Gly His Gln Gly Pro Pro Gly Pro Asp

580 585 590

Glu Cys Glu Ile Leu Asp Ile Ile Met Lys Met Cys Ser Cys Cys Glu

595 600 605

Cys Lys Cys Gly Pro Ile Asp Leu Leu Phe Val Leu Asp Ser Ser Glu

610 615 620

Ser Ile Gly Leu Gln Asn Phe Glu Ile Ala Lys Asp Phe Val Val Lys

625 630 635 640

Val Ile Asp Arg Leu Ser Arg Asp Glu Leu Val Lys Phe Glu Pro Gly

645 650 655

Gln Ser Tyr Ala Gly Val Val Gln Tyr Ser His Ser Gln Met Gln Glu

660 665 670

His Val Ser Leu Arg Ser Pro Ser Ile Arg Asn Val Gln Glu Leu Lys

675 680 685

Glu Ala Ile Lys Ser Leu Gln Trp Met Ala Gly Gly Thr Phe Thr Gly

690 695 700

Glu Ala Leu Gln Tyr Thr Arg Asp Gln Leu Leu Pro Pro Ser Pro Asn

705 710 715 720

Asn Arg Ile Ala Leu Val Ile Thr Asp Gly Arg Ser Asp Thr Gln Arg

725 730 735

Asp Thr Thr Pro Leu Asn Val Leu Cys Ser Pro Gly Ile Gln Val Val

740 745 750

Ser Val Gly Ile Lys Asp Val Phe Asp Phe Ile Pro Gly Ser Asp Gln

755 760 765

Leu Asn Val Ile Ser Cys Gln Gly Leu Ala Pro Ser Gln Gly Arg Pro

770 775 780

Gly Leu Ser Leu Val Lys Glu Asn Tyr Ala Glu Leu Leu Glu Asp Ala

785 790 795 800

Phe Leu Lys Asn Val Thr Ala Gln Ile Cys Ile Asp Lys Lys Cys Pro

805 810 815

Asp Tyr Thr Cys Pro Ile Thr Phe Ser Ser Pro Ala Asp Ile Thr Ile

820 825 830

Leu Leu Asp Gly Ser Ala Ser Ser Val Gly Ser His Asn Phe Asp Thr Thr

835 840 845

Lys Arg Phe Ala Lys Arg Leu Ala Glu Arg Phe Leu Thr Ala Gly Arg

850 855 860

Thr Asp Pro Ala His Asp Val Arg Val Ala Val Val Gln Tyr Ser Gly

865 870 875 880

Thr Gly Gln Gln Arg Pro Glu Arg Ala Ser Leu Gln Phe Leu Gln Asn

885 890 895

Tyr Thr Ala Leu Ala Ser Ala Val Asp Ala Met Asp Phe Ile Asn Asp

900 905 910

Ala Thr Asp Val Asn Asp Ala Leu Gly Tyr Val Thr Arg Phe Tyr Arg

915 920 925

Glu Ala Ser Ser Gly Ala Ala Lys Lys Arg Leu Leu Leu Phe Ser Asp

930 935 940

Gly Asn Ser Gln Gly Ala Thr Pro Ala Ala Ile Glu Lys Ala Val Gln

945 950 955 960

Glu Ala Gln Arg Ala Gly Ile Glu Ile Phe Val Val Val Val Gly Arg

965 970 975

Gln Val Asn Glu Pro His Ile Arg Val Leu Val Thr Gly Lys Thr Ala

980 985 990

Glu Tyr Asp Val Pro Tyr Gly Glu Ser His Leu Phe Arg Val Pro Ser

995 1000 1005

Tyr Gln Ala Leu Leu Arg Gly Val Phe His Gln Thr Val Ser Arg

1010 1015 1020

Lys Val Ala Leu Gly

1025

<210>110

<211>338

<212>PRT

<213> Human (Homo sapiens)

<220>

<221> Basement membrane glycan precursor

<222>(1)..(338)

<223> August 29, 2003 Registration number: P51884

<400>110

Met Ser Leu Ser Ala Phe Thr Leu Phe Leu Ala Leu Ile Gly Gly Thr

1 5 10 15

Ser Gly Gln Tyr Tyr Asp Tyr Asp Phe Pro Leu Ser Ile Tyr Gly Gln

20 25 30

Ser Ser Pro Asn Cys Ala Pro Glu Cys Asn Cys Pro Glu Ser Tyr Pro

35 40 45

Ser Ala Met Tyr Cys Asp Glu Leu Lys Leu Lys Ser Val Pro Met Val

50 55 60

Pro Pro Gly Ile Lys Tyr Leu Tyr Leu Arg Asn Asn Gln Ile Asp His

65 70 75 80

Ile Asp Glu Lys Ala Phe Glu Asn Val Thr Asp Leu Gln Trp Leu Ile

85 90 95

Leu Asp His Asn Leu Leu Glu Asn Ser Lys Ile Lys Gly Arg Val Phe

100 105 110

Ser Lys Leu Lys Gln Leu Lys Lys Leu His Ile Asn His Asn Asn Leu

115 120 125

Thr Glu Ser Val Gly Pro Leu Pro Lys Ser Leu Glu Asp Leu Gln Leu

130 135 140

Thr His Asn Lys Ile Thr Lys Leu Gly Ser Phe Glu Gly Leu Val Asn

145 150 155 160

Leu Thr Phe Ile His Leu Gln His Asn Arg Leu Lys Glu Asp Ala Val

165 170 175

Ser Ala Ala Phe Lys Gly Leu Lys Ser Leu Glu Tyr Leu Asp Leu Ser

180 185 190

Phe Asn Gln Ile Ala Arg Leu Pro Ser Gly Leu Pro Val Ser Leu Leu

195 200 205

Thr Leu Tyr Leu Asp Asn Asn Lys Ile Ser Asn Ile Pro Asp Glu Tyr

210 215 220

Phe Lys Arg Phe Asn Ala Leu Gln Tyr Leu Arg Leu Ser His Asn Glu

225 230 235 240

Leu Ala Asp Ser Gly Ile Pro Gly Asn Ser Phe Asn Val Ser Ser Leu

245 250 255

Val Glu Leu Asp Leu Ser Tyr Asn Lys Leu Lys Asn Ile Pro Thr Val

260 265 270

Asn Glu Asn Leu Glu Asn Tyr Tyr Leu Glu Val Asn Gln Leu Glu Lys

275 280 285

Phe Asp Ile Lys Ser Phe Cys Lys Ile Leu Gly Pro Leu Ser Tyr Ser

290 295 300

Lys Ile Lys His Leu Arg Leu Asp Gly Asn Arg Ile Ser Glu Thr Ser

305 310 315 320

Leu Pro Pro Asp Met Tyr Glu Cys Leu Arg Val Ala Asn Glu Val Thr

325 330 335

Leu Asn

Claims (53)

1, a kind of mark that is used to diagnose cancer of pancreas, it comprises at least a polypeptide of listing in table 2 and table 3 that is selected from.

2, mark according to claim 1, the group that wherein at least a polypeptide is therefrom selected is made up of one group of listed polypeptide of table 2.

3, a kind of table 2 and listed polypeptide of table 3 of being selected from, as being used for cancer of pancreas and/or to the mark of the diagnosis of cancer of pancreas neurological susceptibility or the component of mark.

4, a kind of in-vitro diagnosis cancer of pancreas and/or the method for cancer of pancreas neurological susceptibility be may further comprise the steps:

A) obtain biological specimen; And

B) detect and/or measure the mark that claim 1 or 2 described expression increase.

5, in-vitro method according to claim 4, mark wherein comprises at least two peptide species.

6, according to claim 4 or 5 described in-vitro methods, wherein the biological specimen of indication derives from serum, blood plasma, pancreatic secretion and pancreatic tissue cell.

7, a kind of in-vitro diagnosis cancer of pancreas and/or the method for cancer of pancreas neurological susceptibility be may further comprise the steps:

A) obtain biological specimen; And

B) detect and/or measure the increase of the nucleic acid of at least a coding claim 1 or 2 described marks.

8, in-vitro method according to claim 7, wherein the nucleic acid molecules of indication is RNA or DNA.

9, in-vitro method according to claim 8, wherein the DNA of indication is cDNA.

10,, wherein, the nucleic acid of at least a indication is compared doubting the expression and the expression of identical nucleic acid in healthy individual of suffering from cancer of pancreas and/or the susceptible cancer of pancreas individuality according to any one described in-vitro method among the claim 7-9.

11, according to any one described in-vitro method among the claim 4-6, wherein, with being marked at of at least a indication doubt to suffer from cancer of pancreas and/or the susceptible cancer of pancreas individuality expression with compare with a kind of expression that is marked in the healthy individual.

12, in-vitro method according to claim 11, wherein the increase of the marker expression level of indication is a cancer of pancreas or to the sign of cancer of pancreas neurological susceptibility.

13, a kind of screening technique that is used to identify and/or obtain and list in the interactional compound of polypeptide of table 2 and/or table 3, the polypeptide of indication increases for expressing in cancer of pancreas, and this method may further comprise the steps:

A) polypeptide that makes indication and one or more compounds contact can making under this compound and the interactional condition of the polypeptide of indication; And

B) interaction between the polypeptide of one or more compounds of detection indication and indication.

14, the screening technique of the compound of a kind of inhibitor that is used to identify and/or obtain to belong to table 2 and/or the listed polypeptide of table 3 or antagonist, the polypeptide of indication increases for expressing in cancer of pancreas, and this method may further comprise the steps:

A) polypeptide that makes indication and the compound of identifying by the screening technique of claim 13 and/or obtaining the compound that can make indication with the interactional condition of the polypeptide of saying under contact;

B) activity of mensuration indication polypeptide;

C) according to the definition of (a), be determined at the activity of the indication polypeptide of expressing among the host, this polypeptide does not contact with the compound of indication; And

D) will be at (b) and the active level that records (c) contact, wherein the specific activity that in (b), records in (c), record low, show that this compound is inhibitor or antagonist.

15, a kind of screening technique that is used to identify and/or obtain to belong to the compound of table 2 and/or listed polypeptide expression inhibitor of table 3 or antagonist, the polypeptide of indication increases for expressing in cancer of pancreas, and this method may further comprise the steps:

A) host who expresses the indication polypeptide is contacted with compound;

B) the polypeptide expression level and/or the activity of mensuration indication;

C) according to the definition of (a), measure expression and/or the activity of polypeptide in the host of indication, this host does not contact with the compound of indication; And

D) the described polypeptide expression level that will record at (b) with (c) is quantitatively got in touch, and wherein the expression that records in (b) is lower than what record in (c), shows that then this compound is the polypeptide expression inhibitor of indication.

16, the compound of identifying and/or obtaining by any one described screening technique among the claim 13-15.

17, a kind of pharmaceutical composition, it contains the described compound of claim 16.

18, a kind of method for preparing the described pharmaceutical composition of claim 17 comprises by prescription the described compound of claim 16 is prepared with pharmaceutically useful carrier or thinning agent.

19, the purposes of the described compound of claim 16 in the medicament of preparation treatment and prevention of pancreatic cancer.

20, the purposes of the described compound of claim 16 in the diagnosis composition for preparing the tendency of diagnosing cancer of pancreas or easily suffering from cancer of pancreas.

21, according to claim 19 or 20 described purposes, wherein the compound of indication comprises antibody, antibody derivatives, antibody fragment, peptide or antisense construct thing.

22, be used for diagnosing the table 2 of in-vitro method of cancer of pancreas and/or the antibody of the listed albumen of table 3, or its Fab.

23, a kind of kit of diagnosing cancer of pancreas, it comprises the described antibody of one or more claims 22, or its Fab.

24, a kind of kit of diagnosing cancer of pancreas, it comprises the nucleic acid of the mark of one or more coding claims 1 or 2.

25, a kind of kit that is used for screening compounds, this compound activates or suppresses to list in any polypeptide of table 2 and/or table 3, perhaps stimulates or suppress the polypeptide expression of any indication.

26, a kind of mark that is used to diagnose cancer of pancreas, it comprises at least a listed polypeptide of table 6 that is selected from.

27, mark according to claim 26, wherein at least a polypeptide of indication does not comprise Seq ID No.25 and 50-55.

28, according to any one described mark among the claim 26-27, also comprise the listed polypeptide of at least a table 5 in addition.

29, a kind ofly be used to diagnose cancer of pancreas and/or to the in-vitro method of the neurological susceptibility of cancer of pancreas, it may further comprise the steps:

A) obtain biological specimen; And

B) detect and/or measure the increase of the listed polypeptide of at least a table 6.

30, in-vitro method according to claim 29 also comprises the step that detects and/or measure the minimizing of the listed polypeptide of at least a table 5 in addition.

31, according to claim 29 or 30 described in-vitro methods, wherein at least a polypeptide of indication does not comprise Seq ID No.25 and 50-55.

32, according to any one described in-vitro method of claim 29-31, wherein the biological specimen of indication derives from serum, blood plasma, pancreatic secretion and pancreatic tissue cell.

33, a kind ofly be used to diagnose cancer of pancreas and/or to the in-vitro method of cancer of pancreas neurological susceptibility, it may further comprise the steps:

A) obtain biological specimen; And

B) detect and/or measure the increase of the nucleic acid of any one described mark among at least a coding claim 26-28.

34, in-vitro method according to claim 33, wherein the nucleic acid molecules of indication is RNA or DNA.

35, in-vitro method according to claim 34, wherein the DNA of indication is cDNA.

36, according to any one described in-vitro method of claim 33-35, wherein, the nucleic acid of at least a indication is suffered from cancer of pancreas and/or the expression in healthy individual compares to expression in the individuality of cancer of pancreas susceptible and identical nucleic acid doubting.

37,, wherein, being marked at of indication doubted the expression and the expression of same tag in healthy individual of suffering from cancer of pancreas and/or the susceptible cancer of pancreas individuality compare according to the described in-vitro method of claim 33-36.

38, according to the described in-vitro method of claim 37, wherein the increase of the marker expression level of indication is the sign of cancer of pancreas or cancer of pancreas neurological susceptibility.

39, a kind of screening technique that is used to identify and/or obtain and be selected from the interactional compound of polypeptide of listing in table 6, this polypeptide expression increase for expressing in cancer of pancreas, and this method may further comprise the steps:

A) polypeptide that makes indication and one or more compounds contact can making under this compound and the interactional condition of the polypeptide of indication; And

B) interaction between the polypeptide of one or more compounds of detection indication and indication.

40, a kind of screening technique that is used to identify and/or obtains to belong to the compound of the inhibitor of the listed polypeptide of table 6 or antagonist, the polypeptide expression of indication increases for expressing in cancer of pancreas, and this method may further comprise the steps:

A) polypeptide that makes indication and the compound of identifying by the screening technique of claim 39 and/or obtaining can make this compound with the interactional condition of the polypeptide of saying under contact;

B) activity of mensuration indication polypeptide;

C) according to the definition of (a), be determined at the activity of the indication polypeptide of expressing among the host, this polypeptide does not contact with the compound of indication; And

D) will be at (b) and the active level that records (c) contact, wherein the specific activity that in (b), records in (c), record low, show that then this compound is inhibitor or antagonist.

41, a kind of screening technique that is used to identify and/or obtain to belong to the compound that is selected from the listed polypeptide expression inhibitor of table 6, the polypeptide expression of indication increase for expressing in cancer of pancreas, and this method may further comprise the steps:

A) host who expresses the indication polypeptide is contacted with certain compound;

B) measure indication polypeptide expression level and/or activity;

C) according to the definition of (a), measure indication polypeptide expression levels and/or activity in the host, this host does not contact with the compound of indication; And

D) the described polypeptide expression level that will record at (b) with (c) is quantitatively got in touch, and wherein the expression that records in (b) is lower than what record in (c), shows that this compound is an indication polypeptide expression inhibitor.

42, a kind of compound of identifying or obtaining by any one described screening technique among the claim 39-41.

43, a kind of pharmaceutical composition, it comprises the described compound of claim 42.

44, a kind of method for preparing the described pharmaceutical composition of claim 43 comprises by prescription the described compound of claim 42 is prepared with carrier or thinning agent that can be medicinal.

45, the purposes of the described compound of claim 42 in the medicament of preparation treatment or prevention of pancreatic cancer.

46, the purposes of the described compound of claim 42 in preparing the diagnosis composition of diagnosing cancer of pancreas or easily suffering from the cancer of pancreas tendency.

47, according to claim 45 or 46 described purposes, wherein the compound of indication comprises antibody, antibody derivatives, antibody fragment, peptide or antisense construct thing.

48, can be used for diagnosing the table 5 in the in-vitro method of cancer of pancreas and/or antibody or its Fab of the listed albumen of table 6.

49, a kind of kit of diagnosing cancer of pancreas, it comprises the described antibody of one or more claims 48, or its Fab.

50, a kind of kit of diagnosing cancer of pancreas, it comprises the nucleic acid of the described mark of one or more coding claim 26-28.

51, a kind of kit that is used for screening compounds, this compound activates or suppresses to list in any polypeptide of table 5 and/or table 6, perhaps stimulates or suppress the polypeptide expression of any indication.

52, the described kit of claim 51, wherein the polypeptide of indication is the listed polypeptide of table 6.

53, as indicated above basically, especially in albumen, compound, kit, method and the purposes described in the embodiment above.