CN1799427A - Rheumefmodiwdll extract and its application - Google Patents
Rheumefmodiwdll extract and its application Download PDFInfo
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- CN1799427A CN1799427A CN 200610001355 CN200610001355A CN1799427A CN 1799427 A CN1799427 A CN 1799427A CN 200610001355 CN200610001355 CN 200610001355 CN 200610001355 A CN200610001355 A CN 200610001355A CN 1799427 A CN1799427 A CN 1799427A
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- beverage
- rhei emodi
- radix rhei
- extract
- radix
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- 239000000284 extract Substances 0.000 title claims abstract description 97
- REFJWTPEDVJJIY-UHFFFAOYSA-N Quercetin Chemical compound C=1C(O)=CC(O)=C(C(C=2O)=O)C=1OC=2C1=CC=C(O)C(O)=C1 REFJWTPEDVJJIY-UHFFFAOYSA-N 0.000 claims abstract description 22
- 102000004190 Enzymes Human genes 0.000 claims abstract description 11
- 108090000790 Enzymes Proteins 0.000 claims abstract description 11
- ZVOLCUVKHLEPEV-UHFFFAOYSA-N Quercetagetin Natural products C1=C(O)C(O)=CC=C1C1=C(O)C(=O)C2=C(O)C(O)=C(O)C=C2O1 ZVOLCUVKHLEPEV-UHFFFAOYSA-N 0.000 claims abstract description 11
- HWTZYBCRDDUBJY-UHFFFAOYSA-N Rhynchosin Natural products C1=C(O)C(O)=CC=C1C1=C(O)C(=O)C2=CC(O)=C(O)C=C2O1 HWTZYBCRDDUBJY-UHFFFAOYSA-N 0.000 claims abstract description 11
- 229930003944 flavone Natural products 0.000 claims abstract description 11
- 235000011949 flavones Nutrition 0.000 claims abstract description 11
- MWDZOUNAPSSOEL-UHFFFAOYSA-N kaempferol Natural products OC1=C(C(=O)c2cc(O)cc(O)c2O1)c3ccc(O)cc3 MWDZOUNAPSSOEL-UHFFFAOYSA-N 0.000 claims abstract description 11
- 235000005875 quercetin Nutrition 0.000 claims abstract description 11
- 229960001285 quercetin Drugs 0.000 claims abstract description 11
- 235000013361 beverage Nutrition 0.000 claims description 59
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 24
- 239000007788 liquid Substances 0.000 claims description 18
- 235000003599 food sweetener Nutrition 0.000 claims description 17
- 239000003765 sweetening agent Substances 0.000 claims description 17
- 235000021552 granulated sugar Nutrition 0.000 claims description 15
- 238000001914 filtration Methods 0.000 claims description 13
- JMGZEFIQIZZSBH-UHFFFAOYSA-N Bioquercetin Natural products CC1OC(OCC(O)C2OC(OC3=C(Oc4cc(O)cc(O)c4C3=O)c5ccc(O)c(O)c5)C(O)C2O)C(O)C(O)C1O JMGZEFIQIZZSBH-UHFFFAOYSA-N 0.000 claims description 10
- GAMYVSCDDLXAQW-AOIWZFSPSA-N Thermopsosid Natural products O(C)c1c(O)ccc(C=2Oc3c(c(O)cc(O[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@H](CO)O4)c3)C(=O)C=2)c1 GAMYVSCDDLXAQW-AOIWZFSPSA-N 0.000 claims description 10
- IVTMALDHFAHOGL-UHFFFAOYSA-N eriodictyol 7-O-rutinoside Natural products OC1C(O)C(O)C(C)OC1OCC1C(O)C(O)C(O)C(OC=2C=C3C(C(C(O)=C(O3)C=3C=C(O)C(O)=CC=3)=O)=C(O)C=2)O1 IVTMALDHFAHOGL-UHFFFAOYSA-N 0.000 claims description 10
- 150000002212 flavone derivatives Chemical class 0.000 claims description 10
- 238000000034 method Methods 0.000 claims description 10
- 239000000203 mixture Substances 0.000 claims description 10
- FDRQPMVGJOQVTL-UHFFFAOYSA-N quercetin rutinoside Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC=2C(C3=C(O)C=C(O)C=C3OC=2C=2C=C(O)C(O)=CC=2)=O)O1 FDRQPMVGJOQVTL-UHFFFAOYSA-N 0.000 claims description 10
- IKGXIBQEEMLURG-BKUODXTLSA-N rutin Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@@H]1OC[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](OC=2C(C3=C(O)C=C(O)C=C3OC=2C=2C=C(O)C(O)=CC=2)=O)O1 IKGXIBQEEMLURG-BKUODXTLSA-N 0.000 claims description 10
- ALABRVAAKCSLSC-UHFFFAOYSA-N rutin Natural products CC1OC(OCC2OC(O)C(O)C(O)C2O)C(O)C(O)C1OC3=C(Oc4cc(O)cc(O)c4C3=O)c5ccc(O)c(O)c5 ALABRVAAKCSLSC-UHFFFAOYSA-N 0.000 claims description 10
- 235000005493 rutin Nutrition 0.000 claims description 10
- 229960004555 rutoside Drugs 0.000 claims description 10
- VHBFFQKBGNRLFZ-UHFFFAOYSA-N vitamin p Natural products O1C2=CC=CC=C2C(=O)C=C1C1=CC=CC=C1 VHBFFQKBGNRLFZ-UHFFFAOYSA-N 0.000 claims description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 9
- 239000000843 powder Substances 0.000 claims description 8
- 241000219061 Rheum Species 0.000 claims description 6
- 230000001105 regulatory effect Effects 0.000 claims description 6
- 238000010009 beating Methods 0.000 claims description 5
- 239000002002 slurry Substances 0.000 claims description 5
- 239000006228 supernatant Substances 0.000 claims description 5
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims description 4
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 claims description 2
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 claims description 2
- 239000000706 filtrate Substances 0.000 claims description 2
- 239000004310 lactic acid Substances 0.000 claims description 2
- 235000014655 lactic acid Nutrition 0.000 claims description 2
- 239000001630 malic acid Substances 0.000 claims description 2
- 235000011090 malic acid Nutrition 0.000 claims description 2
- 235000015165 citric acid Nutrition 0.000 claims 2
- 206010021143 Hypoxia Diseases 0.000 abstract description 5
- 230000007954 hypoxia Effects 0.000 abstract description 4
- 241001465754 Metazoa Species 0.000 abstract description 3
- 241000797932 Rheum australe Species 0.000 abstract description 2
- 235000014170 Rheum emodi Nutrition 0.000 abstract description 2
- 150000002213 flavones Chemical class 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 description 34
- 241000699666 Mus <mouse, genus> Species 0.000 description 11
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- 150000001720 carbohydrates Chemical class 0.000 description 7
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- 235000019629 palatability Nutrition 0.000 description 7
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- 239000002253 acid Substances 0.000 description 6
- 238000002474 experimental method Methods 0.000 description 6
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- 238000005352 clarification Methods 0.000 description 4
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- 230000002906 microbiologic effect Effects 0.000 description 3
- 238000002156 mixing Methods 0.000 description 3
- 108090000623 proteins and genes Proteins 0.000 description 3
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- 230000001835 salubrious effect Effects 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- 210000002784 stomach Anatomy 0.000 description 3
- 239000003643 water by type Substances 0.000 description 3
- YDQWDHRMZQUTBA-UHFFFAOYSA-N Aloe emodin Chemical compound C1=CC=C2C(=O)C3=CC(CO)=CC(O)=C3C(=O)C2=C1O YDQWDHRMZQUTBA-UHFFFAOYSA-N 0.000 description 2
- 235000009411 Rheum rhabarbarum Nutrition 0.000 description 2
- 244000193032 Rheum rhaponticum Species 0.000 description 2
- 229920002472 Starch Polymers 0.000 description 2
- 230000037396 body weight Effects 0.000 description 2
- LQGUBLBATBMXHT-UHFFFAOYSA-N chrysophanol Chemical compound C1=CC=C2C(=O)C3=CC(C)=CC(O)=C3C(=O)C2=C1O LQGUBLBATBMXHT-UHFFFAOYSA-N 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
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- 239000000835 fiber Substances 0.000 description 2
- 150000004676 glycans Chemical class 0.000 description 2
- 210000003254 palate Anatomy 0.000 description 2
- FFWOKTFYGVYKIR-UHFFFAOYSA-N physcion Chemical compound C1=C(C)C=C2C(=O)C3=CC(OC)=CC(O)=C3C(=O)C2=C1O FFWOKTFYGVYKIR-UHFFFAOYSA-N 0.000 description 2
- 239000002504 physiological saline solution Substances 0.000 description 2
- 229920001282 polysaccharide Polymers 0.000 description 2
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- 239000008107 starch Substances 0.000 description 2
- 230000001954 sterilising effect Effects 0.000 description 2
- 206010002660 Anoxia Diseases 0.000 description 1
- 241000976983 Anoxia Species 0.000 description 1
- 206010003497 Asphyxia Diseases 0.000 description 1
- 235000005979 Citrus limon Nutrition 0.000 description 1
- 244000131522 Citrus pyriformis Species 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 206010020772 Hypertension Diseases 0.000 description 1
- UGNZSMZSJYOGNX-UHFFFAOYSA-N Isoviocristine Natural products O=C1C=C(C)C(=O)C2=CC3=CC(OC)=CC(O)=C3C(O)=C21 UGNZSMZSJYOGNX-UHFFFAOYSA-N 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- AEMOLEFTQBMNLQ-BKBMJHBISA-N alpha-D-galacturonic acid Chemical compound O[C@H]1O[C@H](C(O)=O)[C@H](O)[C@H](O)[C@H]1O AEMOLEFTQBMNLQ-BKBMJHBISA-N 0.000 description 1
- 230000007953 anoxia Effects 0.000 description 1
- WLXGUTUUWXVZNM-UHFFFAOYSA-N anthraglycoside A Natural products C1=C(C)C=C2C(=O)C3=CC(OC)=CC(O)=C3C(=O)C2=C1OC1OC(CO)C(O)C(O)C1O WLXGUTUUWXVZNM-UHFFFAOYSA-N 0.000 description 1
- 230000001093 anti-cancer Effects 0.000 description 1
- 230000001142 anti-diarrhea Effects 0.000 description 1
- 230000002605 anti-dotal effect Effects 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 230000002785 anti-thrombosis Effects 0.000 description 1
- 239000003146 anticoagulant agent Substances 0.000 description 1
- 230000010100 anticoagulation Effects 0.000 description 1
- 239000000496 cardiotonic agent Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- NZPQWZZXRKZCDU-UHFFFAOYSA-N chrysophanol Natural products Cc1cc(O)c2C(=O)c3c(O)cccc3Oc2c1 NZPQWZZXRKZCDU-UHFFFAOYSA-N 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
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- 230000036039 immunity Effects 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 150000007523 nucleic acids Chemical class 0.000 description 1
- PKUBGLYEOAJPEG-UHFFFAOYSA-N physcion Natural products C1=C(C)C=C2C(=O)C3=CC(C)=CC(O)=C3C(=O)C2=C1O PKUBGLYEOAJPEG-UHFFFAOYSA-N 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
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- 239000002994 raw material Substances 0.000 description 1
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- 230000029058 respiratory gaseous exchange Effects 0.000 description 1
- 230000000452 restraining effect Effects 0.000 description 1
- 238000004062 sedimentation Methods 0.000 description 1
- 229940124513 senna glycoside Drugs 0.000 description 1
- 229930186851 sennoside Natural products 0.000 description 1
- IPQVTOJGNYVQEO-KGFNBKMBSA-N sennoside A Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=CC=CC2=C1C(=O)C1=C(O)C=C(C(O)=O)C=C1[C@@H]2[C@H]1C2=CC(C(O)=O)=CC(O)=C2C(=O)C2=C(O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O3)O)C=CC=C21 IPQVTOJGNYVQEO-KGFNBKMBSA-N 0.000 description 1
- 235000019614 sour taste Nutrition 0.000 description 1
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- Non-Alcoholic Beverages (AREA)
Abstract
The invention discloses a Rheum australe extract and its use, wherein the extract comprises total flavones 908-1832 mg/100g, citroflavina 1.51-30.22mg/100g, quercetin 0.19-3.92mg/100g, and SOD enzyme 138-276 U/g. The extract can improve animal's hypoxia-resistant capacity and sport ability appreciably.
Description
Technical field
The present invention relates to a kind of Radix Rhei emodi extract and application thereof.
Background technology
Radix Rhei emodi (Rheum emodi Wall.) is a polygonaceae Rheum ripple leaf group plant, and its root and rhizome can be used as medicine.The characteristics of Radix Rhei emodi root and rhizome are not contain the sennoside that tool mainly causes the effect of rushing down, and contain the archen of ponticin, rheum rhabarbarum polysaccharide, Chrysophanol, Physcion and trace.And contain a spot of aloe-emodin.Restraining epiphyte, convergence, antidiarrheal, reduction blood fat are arranged and slightly cause effect such as rush down.That wherein contained rheum rhabarbarum polysaccharide has is anticancer, radioresistance, anti-inflammatory, anticoagulation, antithrombotic, cardiac stimulant, bring high blood pressure down, reduce blood fat, reduce blood sugar, strengthen body's immunity and nucleic acid, protein is synthetic and antidotal effect.
Gathering the Radix Rhei emodi rhizome can damage local vegetation.The annual 7-9 month all can grow petiole on the rhizome of Radix Rhei emodi, and is withered naturally about October, also can grow once more in 1 year.Radix Rhei emodi petiole sweet and sour taste always as one of local often edible fruit, is subjected to people's favor for many years deeply.
Summary of the invention
Problem to be solved by this invention provides a kind of Radix Rhei emodi extract and application thereof.
Radix Rhei emodi extract provided by the invention, its active ingredient is general flavone 9.08mg/100g-18.32 * 10mg/100g, rutin 1.51mg/100g-30.22mg/100g, Quercetin 0.19mg/100g-3.92mg/100g, SOD enzyme 1.38 * 10U/g-2.76 * 10
2U/g.
The present invention also provides a kind of Radix Rhei emodi extract powder, and this solid Radix Rhei emodi extract contains 3.67 * 10
2-16.49 * 10
3The Quercetin, 6.21 * 10 of the general flavone of mg/100g, the rutin of 68.04-271.98mg/100g, 8.82-35.28mg/100g
2-2.48 * 10
3The SOD enzyme of U/g.
Described Radix Rhei emodi extract can be made by following method: mixed with the 0.5-10 water doubly that is described rheum leave and stem quality 1) with after the making beating of Radix Rhei emodi petiole, making slurry grain fineness is the mixed liquid of 0.1-0.5mm; 2) rough and careless: as will to mix liquid and filter the footpath and be the filtration of 0.2-0.4mm; 3) smart filter: with step 2) filtrate that obtains is with the rotating speed of 1000-3000rpm, the centrifugal 5-30min of centrifugal radius of 8-15cm, and the supernatant that obtains is the Radix Rhei emodi extract.Described Radix Rhei emodi extract obtains Radix Rhei emodi extract solid powder through super-dry.
The drink or the beverage that contain above-mentioned Radix Rhei emodi extract also belong to protection scope of the present invention.
The described Radix Rhei emodi extract beverage that contains can be above-mentioned Radix Rhei emodi extract and water with 1: the volume ratio of 0-5 is mixed, adds sweetener, and the quality percentage composition that makes described sweetener is 1%-20%, and the pH value transfers to 2.5-3.8.
Described sweetener can be A Batian, albumen sugar, granulated sugar, sweetener etc., wherein is preferably white granulated sugar.
The interpolation quality percentage composition of described sweetener is preferably 7.0%-7.2%.
Described pH value is preferably 3.4.
The available citric acid of described pH value, malic acid or lactic acid are regulated, and wherein are preferably with citric acid and regulate.
Described drink or beverage can liquid forms or are existed with solid form through super-dry.
Preserve for convenience, described drink or beverage can use method sterilization backs such as pasteurize, UHTS, instantaneous sterilizing to preserve.
The protein content 0.02-0.72% that contains Radix Rhei emodi extract beverage of the present invention, carbohydrate content 0.23-6.8%, soluble dietary fiber 0.27-6.6%.
Mouse is fed experiment and shows, Radix Rhei emodi extract of the present invention and the beverage that contains this Radix Rhei emodi extract can obviously improve hypoxia-bearing capability and the locomitivity of animal.The present invention is a raw material with the Radix Rhei emodi petiole first, has developed a kind of novel beverage.Coarse filtration can be removed most pectic substance, most of fiber and partially protein and starch, and smart filter is centrifugal with remainder fiber, protein and starch.Through above processing, efficiently solve the sedimentation problem of beverage.This beverage normal temperature was placed 1 year, and the color and luster local flavor does not have change, sour and sweet palatability, pleasant to the palate, and liquid still clarifies as before, and deposit-free or other floccules are separated out, contained various active constituent contents only reduce 1-2%, have kept the natural colored and the fragrance of Radix Rhei emodi petiole.This product does not contain anticorrisive agent and pigment, and normal temperature is placed, 1 year shelf-life.
The specific embodiment
Experimental technique among the following embodiment if no special instructions, is conventional method.
Percentage composition among the following embodiment is the quality percentage composition if no special instructions.
Embodiment 1, Radix Rhei emodi extract and contain the preparation of the beverage of Radix Rhei emodi extract
1, the preparation of Radix Rhei emodi extract
1) get Radix Rhei emodi petiole 10kg and clean, stripping and slicing, making beating, slurry grain fineness is 0.1mm, adds 5 times water of rheum leave and stem quality, mixing; 2) coarse filtration: with the aperture is the plate compression of 0.3mm, discards filter residue, obtains coarse filtration liquid; 3) smart filter: coarse filtration liquid with the rotating speed of 3000rpm, the centrifugal 25min of centrifugal radius of 8cm, is obtained the 53.8kg supernatant, be the Radix Rhei emodi extract.After testing, this contains general flavone 1.53 * 10mg/100g, rutin 2.52mg/100g, Quercetin 0.32mg/100g with the Radix Rhei emodi extract, SOD enzyme 2.3 * 10U/g.This Radix Rhei emodi extract obtains the 120g pressed powder through drying under reduced pressure, after testing, this solid Radix Rhei emodi extract powder, this solid Radix Rhei emodi extract contains 7.65 * 10
3The Quercetin, 1.25 * 10 of the general flavone of mg/100g, the rutin of 136.4mg/100g, 17.14mg/100g
3The SOD enzyme of U/g.
2, the preparation of beverage
1) selection of sweetener
Get the Radix Rhei emodi extract of preparation in the step 1, be divided into four parts, add 8% A Batian, albumen sugar 50 types, white granulated sugar, sweetener respectively.Taste taste then, the result is as shown in table 1, can determine that from table 1 best sweetener is a white granulated sugar.
The best sweetener of table 1. is selected
| A Batian | Albumen sugar 50 types | White granulated sugar | Sweetener |
| Refrigerant sense is arranged | Mouthfeel is relatively poor | Delicate mouthfeel, lubricated | Mouthfeel is relatively poor |
2) get the Radix Rhei emodi extract for preparing in the step 1, be divided into 12 parts, add, taste taste, can determine that from table 2 best mouthfeel is pH3.4, white granulated sugar 7.0%-7.2% according to white granulated sugar amount in the table 2 and citric acid amount.
The best taste flavour of table 2.
| The lemon acid for adjusting pH | White granulated sugar 6.5% | White granulated sugar 7.0% | White granulated sugar 7.2% | White granulated sugar 7.5% |
| 3.0 | Acid | Acid | Acid | Acid |
| 3.4 | Acid | Sour and sweet palatability | Sour and sweet palatability | Sweet |
| 4.0 | Sweeter | Sweet | Sweet | Sweet |
3) contain the preparation of the beverage of Radix Rhei emodi extract: with 3 times of the above-mentioned Radix Rhei emodi extract 10kg dilute with waters that obtains, it is 7.2% that interpolation sweetener white granulated sugar makes its quality percentage composition, with citric acid regulating solution pH value to 3.4, through UHTS, obtain containing the beverage of Radix Rhei emodi extract.This beverage color and luster is a lightpink, sour and sweet palatability, fragrant and salubrious, and the liquid clarification is stable.Detect by the physical and chemical index of GB/T12295 method to this beverage, with the GB4789.2 method microbiological indicator is detected, the result shows, physical and chemical index: protein content 0.06%, carbohydrate content 0.8%, soluble dietary fiber 1.03%.Content of microorganisms: total number of bacteria≤100/ml, coliform≤3/ml, pathogenic bacteria do not detect.
Embodiment 2, Radix Rhei emodi extract and contain the preparation of the beverage of Radix Rhei emodi extract
1, the preparation of Radix Rhei emodi extract
1) get Radix Rhei emodi petiole 10kg and clean, stripping and slicing, making beating, slurry grain fineness is 0.1mm, adds 0.5 times water of rheum leave and stem quality, mixing; 2) coarse filtration: with the aperture is 0.2 plate compression, discards filter residue, obtains coarse filtration liquid; 3) smart filter: coarse filtration liquid with the rotating speed of 3000rpm, the centrifugal 15min of centrifugal radius of 8cm, is obtained the 14.1kg supernatant, be the Radix Rhei emodi extract.After testing, this contains general flavone 6.11 * 10mg/100g, rutin 10.03mg/100g, Quercetin 1.36mg/100g with the Radix Rhei emodi extract, SOD enzyme 9.8 * 10U/g.This Radix Rhei emodi extract obtains the 120g pressed powder through drying under reduced pressure, after testing, this solid Radix Rhei emodi extract powder, this solid Radix Rhei emodi extract contains 8.12 * 10
3The Quercetin, 2 * 10 of the general flavone of mg/100g, the rutin of 138mg/100g, 20mg/100g
3The SOD enzyme of U/g.
2, contain the preparation of the beverage of Radix Rhei emodi extract: with 2 times of the above-mentioned Radix Rhei emodi extract 10kg dilute with waters that obtains, it is 5.0% that interpolation sweetener white granulated sugar makes its quality percentage composition, with citric acid regulating solution pH value to 2.5, through UHTS, obtain containing the beverage of Radix Rhei emodi extract.This beverage color and luster is a lightpink, sour and sweet palatability, fragrant and salubrious, and the liquid clarification is stable.Detect by the physical and chemical index of GB/T12295 method to this beverage, with the GB4789.2 method microbiological indicator is detected, the result shows, physical and chemical index: protein content 0.26%, carbohydrate content 2.56%, soluble dietary fiber 3.23%.Content of microorganisms: total number of bacteria≤100/ml, coliform≤3/ml, pathogenic bacteria do not detect.
Embodiment 3, Radix Rhei emodi extract and contain the preparation of the beverage of Radix Rhei emodi extract
1, the preparation of Radix Rhei emodi extract
1) get Radix Rhei emodi petiole 10kg and clean, stripping and slicing, making beating, slurry grain fineness is 0.3mm, adds 10 times water of rheum leave and stem quality, mixing; 2) coarse filtration: with the aperture is the plate compression of 0.3mm, discards filter residue, obtains coarse filtration liquid; 3) smart filter: coarse filtration liquid with the rotating speed of 3000rpm, the centrifugal 20min of centrifugal radius of 15cm, is obtained the 93.0kg supernatant, be the Radix Rhei emodi extract.After testing, this contains general flavone 9.08mg/100g, rutin 1.51mg/100g, Quercetin 0.19mg/100g with the Radix Rhei emodi extract, SOD enzyme 1.38 * 10U/g.This Radix Rhei emodi extract obtains the 119g pressed powder through drying under reduced pressure, and after testing, this solid Radix Rhei emodi extract contains 8.1 * 10
3The Quercetin, 1.9 * 10 of the general flavone of mg/100g, the rutin of 190mg/100g, 21mg/100g
3The SOD enzyme of U/g.
2, contain the preparation of the beverage of Radix Rhei emodi extract: with 5 times of the above-mentioned Radix Rhei emodi extract 10kg dilute with waters that obtains, it is 9.2% that interpolation sweetener white granulated sugar makes its quality percentage composition, with citric acid regulating solution pH value to 3.8, through UHTS, obtain containing the beverage of Radix Rhei emodi extract.This beverage color and luster is a lightpink, sour and sweet palatability, fragrant and salubrious, and the liquid clarification is stable.Detect by the physical and chemical index of GB/T12295 method to this beverage, with the GB4789.2 method microbiological indicator is detected, the result shows, physical and chemical index: protein content 0.04%, carbohydrate content 0.46%, soluble dietary fiber 0.54%.Content of microorganisms: total number of bacteria≤100/ml, coliform≤3/ml, pathogenic bacteria do not detect.
Embodiment 4, the product quality of beverage that contains the Radix Rhei emodi extract and mouse are fed experiment
1, stability is measured: with the beverage sealing of preparation among embodiment 1, embodiment 2 and the embodiment 3, placed at normal temperatures 1 year, observe its color and luster, turbidity then, taste taste, and carry out physical and chemical index and content of microorganisms detects.The result show beverage through the normal temperature in 1 year sealing preserve, the color and luster local flavor does not have change, sour and sweet palatability is pleasant to the palate, and liquid throws away clarification as before, deposit-free or other floccules are separated out.The detection physical and chemical index shows: the beverage pH value of preparation is 3.4 among the embodiment 1, protein content 0.07%, carbohydrate content 0.8%, soluble dietary fiber 1.03%.The beverage pH value of preparation is 2.7 among the embodiment 2, protein content 0.26%, carbohydrate content 2.56%, soluble dietary fiber 3.23%.The beverage pH value of preparation is 3.8 among the embodiment 3, protein content 0.04%, carbohydrate content 0.46%, soluble dietary fiber 0.54%.The beverage content of microorganisms of the foregoing description 1, embodiment 2 and embodiment 3 preparations: total number of bacteria≤100/ml, coliform≤3/ml, pathogenic bacteria do not detect.
2, mouse is fed experiment
(1) anoxia tolerance experiment: mouse is divided into control group at random, the Radix Rhei emodi extract experimental group of embodiment 1 preparation, the Radix Rhei emodi extract beverage experimental group of embodiment 1 preparation, the Radix Rhei emodi extract experimental group of embodiment 2 preparations, the Radix Rhei emodi extract beverage experimental group of embodiment 2 preparations, the Radix Rhei emodi extract experimental group of embodiment 3 preparations, the Radix Rhei emodi extract beverage experimental group of embodiment 3 preparations, every group 20, be male.The environment unanimity that each experimental group is raised, temperature is 27 ℃, relative humidity is 60%, natural lighting, all the feeding standard basal feed is irritated stomach Radix Rhei emodi extract, Radix Rhei emodi extract beverage or physiological saline simultaneously respectively, and its dosage is as follows: Radix Rhei emodi extract experimental group is given the Radix Rhei emodi extract of embodiment 1 step 1, embodiment 2 steps 1 and the preparation of embodiment 3 steps 1 respectively, every every day 0.1ml Radix Rhei emodi extract, 21d feeds; Radix Rhei emodi extract beverage experimental group is given the beverage of embodiment 1 step 2, embodiment 2 steps 2 and the preparation of embodiment 3 steps 2 respectively, every Radix Rhei emodi extract beverage every day (containing 0.1ml Radix Rhei emodi extract), and 21d feeds; Control group is given equivalent physiological saline.30min behind the last feeding is contained in three groups of mouse respectively in the 500ml wide-mouth bottle, seals immediately, observes mouse because of the anoxic death by suffocation time.Stopping with mouse breathing serves as to judge death standard.The result shows that the average tolerance time of control group mice is 30.8 ± 3.8min, the average tolerance time of Radix Rhei emodi extract experimental mice of embodiment 1, embodiment 2 and embodiment 3 preparations is respectively 32.6 ± 4.0min, 36.7 ± 3.9min and 31.0 ± 2.8min.The average tolerance time of Radix Rhei emodi extract beverage experimental mice of embodiment 1, embodiment 2 and embodiment 3 preparations is respectively 31.9 ± 3.6min, 35.9 ± 4.2min and 30.9 ± 3.1min.The Radix Rhei emodi extract experimental group of embodiment 2, Radix Rhei emodi extract beverage experimental group and the equal difference of control group is (P＜0.05) significantly, and the Radix Rhei emodi extract experimental group of embodiment 1, embodiment 3, Radix Rhei emodi extract beverage experimental group do not have significant difference.(table 3).Radix Rhei emodi extract and beverage that the certain content of the present invention is described can obviously improve the hypoxia-bearing capability of animal.
Table 3 Radix Rhei emodi beverage is to the influence of mouse hypoxia-bearing capability
| Group | Sex | Mean survival time min | Average rate elongation % | Grow up to most live time min |
| Control group | Male | 30.8±3.8 | 34.6 | |
| The Radix Rhei emodi extract experimental group of embodiment 1 preparation | Male | 32.6±3.0 | 5.8 | 35.6 |
| The Radix Rhei emodi extract beverage experimental group of embodiment 1 preparation | Male | 31.9±3.6 | 3.6 | 35.5 |
| The Radix Rhei emodi of embodiment 2 preparations is carried | Male | 36.7±3.9 | 19.16 | 40.5 |
| Get the liquid experimental group | ||||
| The Radix Rhei emodi extract beverage experimental group of embodiment 2 preparations | Male | 35.9±4.2 | 16.56 | 40.1 |
| The Radix Rhei emodi extract experimental group of embodiment 3 preparations | Male | 31.0±2.8 | 0.64 | 33.8 |
| The Radix Rhei emodi extract beverage experimental group of embodiment 3 preparations | Male | 30.9±3.1 | 0.32 | 34.0 |
(2) labour capacity experiment:
Feed according to the grouping of the method for step (1), behind the last feeding 30min, with bear a heavy burden the respectively sheet lead of 10% body weight of body weight of mouse, be put in the swimming groove of 37 ℃ of water temperatures and swim, the record mouse is from the time that begins to swim to the first mouthful of water of choking.The result shows that the average swimming time of control group is 1.23 ± 0.35min, the average swimming time of Radix Rhei emodi extract group of irritating stomach embodiment 1, embodiment 2 and embodiment 3 preparations respectively is respectively 2.56 ± 0.29min, 3.87 ± 0.58min and 1.35 ± 0.39min.The average swimming time of Radix Rhei emodi extract beverage group of irritating stomach embodiment 1, embodiment 2 and embodiment 3 preparations respectively is respectively 2.06 ± 0.39min, 3.64 ± 0.56min and 1.29 ± 0.38min.The Radix Rhei emodi extract experimental group of embodiment 2, Radix Rhei emodi extract beverage experimental group and the equal difference of control group is (P＜0.05) significantly, and the Radix Rhei emodi extract experimental group of embodiment 1, embodiment 3, Radix Rhei emodi extract beverage experimental group do not have significant difference.The Radix Rhei emodi extract of certain content of the present invention and the locomitivity that beverage can significantly improve mouse are described.
Claims (10)
1, a kind of Radix Rhei emodi extract is general flavone 9.08mg/100g-18.32 * 10mg/100g, rutin 1.51mg/100g-30.22mg/100g, Quercetin 0.19mg/100g-3.92mg/100g, SOD enzyme 1.38 * 10U/g-2.76 * 10
2The liquid of U/g.
2, Radix Et Rhizoma Rhei extract according to claim 1, it is characterized in that: described Radix Rhei emodi extract can be made by following method: 1) with after the making beating of Radix Rhei emodi petiole, mixed with the 0.5-10 water doubly that is described rheum leave and stem quality, making slurry grain fineness is the mixed liquid of 0.1-0.5mm; 2) coarse filtration: will mix liquid and filter the footpath and be the filtration of 0.2-0.4mm; 3) smart filter: with step 2) filtrate that obtains is with the rotating speed of 1000-3000rpm, the centrifugal 5-30min of centrifugal radius of 8-15cm, and the supernatant that obtains is the Radix Rhei emodi extract.
3, a kind of Radix Rhei emodi extract is to contain 3.67 * 10
2-16.49 * 10
3The Quercetin, 6.21 * 10 of the general flavone of mg/100g, the rutin of 68.04-271.98mg/100g, 8.82-35.28mg/100g
2-2.48 * 10
3The pressed powder of the SOD enzyme of U/g.
4, the drink or the beverage that contain claim 1 or 2 described Radix Rhei emodi extracts.
5, drink according to claim 4 or beverage, it is characterized in that: the described Radix Rhei emodi extract beverage that contains is prepared as follows: with the described Radix Rhei emodi extract of claim 2 and water with 1: the volume ratio of 0-5 is mixed, add sweetener, the quality percentage composition that makes described sweetener is 1%～20%, and the pH value transfers to 2.5-3.8.
6, drink according to claim 5 or beverage is characterized in that: described pH value transfers to 3.4.
7, drink according to claim 6 or beverage is characterized in that: the quality percentage composition of described sweetener is 7.0%～7.2%, and described sweetener is a white granulated sugar.
8, drink according to claim 6 or beverage is characterized in that: described pH value is regulated with citric acid, malic acid or lactic acid.
9, drink according to claim 9 or beverage is characterized in that: described pH value is regulated with citric acid.
10, the drink or the beverage that contain the described Radix Rhei emodi extract of claim 3.
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| CN102228519A (en) * | 2011-06-24 | 2011-11-02 | 西藏金哈达药业有限公司 | Application of extract of Rheum emodi Wall. in preparing medicine for controlling ischemic heart disease (IHD) |
| CN101428078B (en) * | 2008-12-16 | 2011-11-23 | 西藏金哈达药业有限公司 | Tibetan medicine composition for governing blood fat and preparation thereof |
| CN103027355A (en) * | 2011-10-09 | 2013-04-10 | 王永红 | Composition and preparation method of cooling drink |
| CN104257767A (en) * | 2014-09-19 | 2015-01-07 | 西藏藏真堂藏药产业有限公司 | Method for extracting active ingredients of rheum australe and application thereof |
| CN104288286A (en) * | 2014-09-19 | 2015-01-21 | 西藏藏真堂藏药产业有限公司 | Pharmaceutical composition containing rheum emodi wall as well as extracting liquor and application thereof |
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| US6136316A (en) * | 1996-04-17 | 2000-10-24 | Dabur Research Foundation | Hepatoprotective compositions and composition for treatment of conditions related to hepatitis B and E infection |
| CN1060326C (en) * | 1997-01-31 | 2001-01-10 | 青海绿色药物研究所 | Rhubarb juice beverage and its prodn. method |
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| CN101428078B (en) * | 2008-12-16 | 2011-11-23 | 西藏金哈达药业有限公司 | Tibetan medicine composition for governing blood fat and preparation thereof |
| CN102228519A (en) * | 2011-06-24 | 2011-11-02 | 西藏金哈达药业有限公司 | Application of extract of Rheum emodi Wall. in preparing medicine for controlling ischemic heart disease (IHD) |
| CN103027355A (en) * | 2011-10-09 | 2013-04-10 | 王永红 | Composition and preparation method of cooling drink |
| CN103027355B (en) * | 2011-10-09 | 2013-12-18 | 王永红 | Composition and preparation method of cooling drink |
| CN104257767A (en) * | 2014-09-19 | 2015-01-07 | 西藏藏真堂藏药产业有限公司 | Method for extracting active ingredients of rheum australe and application thereof |
| CN104288286A (en) * | 2014-09-19 | 2015-01-21 | 西藏藏真堂藏药产业有限公司 | Pharmaceutical composition containing rheum emodi wall as well as extracting liquor and application thereof |
| CN104288286B (en) * | 2014-09-19 | 2017-09-12 | 西藏藏真堂藏药产业有限公司 | A kind of pharmaceutical composition containing Radix Rhei emodi, extract solution and its application |
| CN107734976A (en) * | 2015-07-03 | 2018-02-23 | 阿纳里蒂科探索有限责任公司 | Natural stilbene compound is as sweetener or sweetness enhancers |
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