CN1765382A - Chinese medicinal compound formulation for treating gynecological inflammation and its preparation method - Google Patents
Chinese medicinal compound formulation for treating gynecological inflammation and its preparation method Download PDFInfo
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- CN1765382A CN1765382A CN 200510097960 CN200510097960A CN1765382A CN 1765382 A CN1765382 A CN 1765382A CN 200510097960 CN200510097960 CN 200510097960 CN 200510097960 A CN200510097960 A CN 200510097960A CN 1765382 A CN1765382 A CN 1765382A
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- FPAFDBFIGPHWGO-UHFFFAOYSA-N dioxosilane;oxomagnesium;hydrate Chemical compound O.[Mg]=O.[Mg]=O.[Mg]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O FPAFDBFIGPHWGO-UHFFFAOYSA-N 0.000 claims description 2
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- Medicines Containing Plant Substances (AREA)
Abstract
Disclosed is a Chinese medicinal compound formulation for treating gynecological inflammation and its preparation method, wherein each 1000 dosage unit comprises the following medicinal raw materials (by weight portion), and honey-suckle stem 450 parts, sargentgloryvine 450 parts, licorice root 45 parts, dyers woad leaf 45 parts, dandehon herb 135 parts, red peony root 135 parts, rheum officinale 90 parts, radix salvia miltiorrhiza 135 parts, giant knotweed rhizome 135 parts, toosendan fruit 135 parts, and corydalis tuber 135 parts.
Description
Technical field:
The invention belongs to field of medicaments, relate to a kind of compound Chinese medicinal preparation for the treatment of gynaecopathia and preparation method thereof.Be specifically related to a kind of clearing away heat and cooling blood that has, the promoting blood circulation and stopping pain effect be used for the treatment of the profuse leukorrhea that gynecological inflammation causes, Chinese medicine preparation of stomachache and preparation method thereof.
Background technology:
Gynecological's internal genitalia inflammation, comprise adnexitis, pelvic inflammatory disease, the other cellulites in palace, endometritis etc., be gynecological's common frdquently encountered disease, doctor trained in Western medicine adopts antibiotic therapy and physical therapy, but because the adhesion of inflammation focus hypertrophy, drug absorption is bad, and because the appearance of Resistant strain, make antibiotic curative effect have a greatly reduced quality, and side effect is many, easily recurrence.
The traditional Chinese medical science is included it in " leukorrhagia ", " dysmenorrhea ", “ mass in the abdomen " etc. the disease category.Its pathogenesis mostly is invades in damp and hot, pents up the uterus vessels of the uterus, and the damp and hot multiple abscess part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels is then seen profuse leukorrhea; If damp and hot retardance QI and blood, blood and accumulation of heat, blood stasis hinder in the uterus vessels of the uterus, then can cause stomachache; The knot if damp and hot and QI and blood is fought, then Fa is a mass in the abdomen.Therefore, always not from wet, heat, the stasis of blood.Medicine of the present invention is applicable to that treatment heat in blood, blood stasis are heavier, and the not obvious person of damp, treatment is with clearing away heat and cooling blood, and promoting blood circulation and stopping pain is a method.
The sickness rate of gynecological's internal genitalia inflammation is very high, accounts for more than 4% of married woman.Therefore, patient colony is huge, and the medicine of treatment gynecological inflammation has the very big market space, so medicine of the present invention will bring huge economic benefit and social benefit.
Summary of the invention:
The invention provides a kind of compound Chinese medicinal preparation for the treatment of gynecological inflammation and preparation method thereof.It is characterized in that in per 1000 dosage units, the raw material of Chinese medicine that contains following weight parts is made:
45 parts in 450 portions of Radix Glycyrrhizaes of 450 portions of Caulis Sargentodoxae of Caulis Lonicerae
135 parts of 135 parts of Radix Paeoniae Rubra of 45 parts of Herba Taraxacis of Folium Isatidis
135 parts of 135 parts of Rhizoma Polygoni Cuspidati of 90 parts of Radix Salviae Miltiorrhizaes of Radix Et Rhizoma Rhei (system)
135 parts of 135 parts of Rhizoma Corydalis of Fructus Toosendan (system) (system)
Pharmaceutical preparation of the present invention, be by with raw material of Chinese medicine through extraction thick paste, with the fine drug powder mixing, add the medicine acceptable carrier when needing, make according to the routine techniques of galenic pharmacy.
Pharmaceutical preparation of the present invention can be any pharmaceutically useful dosage form, and these dosage forms comprise: tablet, capsule, granule, pill, powder, oral liquid, syrup, unguentum, sublimed preparation, drop pill, patch, slow releasing preparation, controlled release preparation.
Preferably capsule, pill, tablet and granule.
Pharmaceutical preparation of the present invention, the preparation of its oral administration can contain excipient commonly used, as filler, binding agent, disintegrating agent, lubricant, correctives, can carry out coating to tablet in case of necessity.
Wherein filler can be selected starch, Icing Sugar, dextrin, microcrystalline Cellulose, lactose, amylum pregelatinisatum, mannitol, calcium hydrogen phosphate etc.
Wherein binding agent can be selected starch slurry, polyvinylpyrrolidone aqueous solution or alcoholic solution, gelling starch, sodium carboxymethyl cellulose solution etc., also can select water, Mel or water-honey liquor in the pill.
Wherein disintegrating agent can be selected carboxymethyl starch sodium, low-substituted hydroxypropyl cellulose, crospolyvinylpyrrolidone, cross-linking sodium carboxymethyl cellulose etc.
Wherein lubricant can be selected magnesium stearate, Macrogol 4000 or polyethylene glycol 6000, Pulvis Talci, sodium lauryl sulphate, micropowder silica gel etc.
Wherein correctives can be selected aspartame, flavoring orange essence, Herba Menthae essence etc.
The preparation method of compound medicinal formulation provided by the invention, can pass through following steps:
(1) Rhizoma Corydalis (system) is ground into fine powder, and is standby.
(2) Radix Salviae Miltiorrhizae, Radix Paeoniae Rubra, Rhizoma Polygoni Cuspidati add ethanol, the heating and refluxing extraction secondary, and each 2 hours, merge extractive liquid, filtered, and filtrate recycling ethanol also is concentrated into the thick paste that relative density is 1.36 (60 ℃).
(3) seven flavors such as medicinal residues and all the other Caulis Loniceraes decoct with water three times, and 2 hours for the first time, 1.5 hours for the second time, 1 hour for the third time, collecting decoction filtered, and filtrate decompression is concentrated into the thick paste that relative density is 1.36 (60 ℃).
(4) thick paste and the Rhizoma Corydalis fine powder mix homogeneously that (2) and (3) are made, vacuum drying is pulverized, and promptly gets active constituents of medicine.
With active constituents of medicine and mixed capsule, tablet, pill or the granule of getting of medicine acceptable auxiliary that makes.
Following data is in order to illustrate the beneficial effect of medicine of the present invention:
The gynecologic patient of picked at random 122 routine internal reproductive organ inflammation, comprise urgent chronic pelvic inflammatory disease, adnexitis, endometritis etc., symptom such as leukorrheal diseases, menoxenia, dysmenorrhea with TCM Gynecology, take medicinal tablet of the present invention, 1 time 5,3 times on the 1st, 7 was 1 course of treatment, serve on 2～3 courses of treatment in case of necessity.As a result, cure 49 examples (40.2%), produce effects 15 examples (12.3%), effective 53 examples (43.4%), total effective rate reaches 95.9%.
The specific embodiment:
Specific embodiment is as follows, includes but not limited to the following example.
Embodiment 1:
The preparation method of capsule of the present invention:
Caulis Lonicerae 450g Caulis Sargentodoxae 450g Radix Glycyrrhizae 45g
Folium Isatidis 45g Herba Taraxaci 135g Radix Paeoniae Rubra 135g
Radix Et Rhizoma Rhei (system) 90g Radix Salviae Miltiorrhizae 135g Rhizoma Polygoni Cuspidati 135g
Fructus Toosendan (system) 135g Rhizoma Corydalis (system) 135g
95% ethanol is an amount of
Make 1000
Preparation method: above ten simply, and Rhizoma Corydalis (system) is ground into fine powder, and is standby.Radix Salviae Miltiorrhizae, Radix Paeoniae Rubra, Rhizoma Polygoni Cuspidati add ethanol, the heating and refluxing extraction secondary, and each 2 hours, merge extractive liquid, filtered, and filtrate recycling ethanol also is concentrated into the thick paste that relative density is 1.36 (60 ℃), and is standby.Seven flavors such as medicinal residues and all the other Caulis Loniceraes decoct with water three times, 2 hours for the first time, 1.5 hours for the second time, 1 hour for the third time, collecting decoction, filter, filtrate decompression is concentrated into the thick paste that relative density is 1.36 (60 ℃), with above-mentioned thick paste and Rhizoma Corydalis fine powder mix homogeneously, vacuum drying is pulverized the starch slurry 24 mesh sieve system soft materials with 10%, put 70 ℃ of vacuum dryings, 20 mesh sieve granulate incapsulate, promptly.
Embodiment 2:
The preparation method of tablet of the present invention:
Caulis Lonicerae 450g Caulis Sargentodoxae 450g Radix Glycyrrhizae 45g
Folium Isatidis 45g Herba Taraxaci 135g Radix Paeoniae Rubra 135g
Radix Et Rhizoma Rhei (system) 90g Radix Salviae Miltiorrhizae 135g Rhizoma Polygoni Cuspidati 135g
Fructus Toosendan (system) 135g Rhizoma Corydalis (system) 135g
10% polyvidone alcoholic solution is an amount of
Carboxymethyl starch sodium 10g
Magnesium stearate 5g
Make 1000
Preparation method: above ten simply, and Rhizoma Corydalis (system) is ground into fine powder, and is standby.Radix Salviae Miltiorrhizae, Radix Paeoniae Rubra, Rhizoma Polygoni Cuspidati add ethanol, the heating and refluxing extraction secondary, and each 2 hours, merge extractive liquid, filtered, and filtrate recycling ethanol also is concentrated into the thick paste that relative density is 1.36 (60 ℃), and is standby.Seven flavors such as medicinal residues and all the other Caulis Loniceraes, decoct with water three times, 2 hours for the first time, 1.5 hours for the second time, 1 hour for the third time, collecting decoction, filter, filtrate decompression is concentrated into the thick paste that relative density is 1.36 (60 ℃), with above-mentioned thick paste and Rhizoma Corydalis fine powder mix homogeneously, add carboxymethyl starch sodium (2/3), with 10% polyvidone alcoholic solution system, 24 mesh sieve soft materials, put drying in 70 ℃ of vacuum drying ovens, 20 mesh sieve granulate, add the residue carboxymethyl starch sodium, magnesium stearate, mix homogeneously, tabletting, coating, promptly.
Embodiment 3:
The preparation method of pill of the present invention:
Caulis Lonicerae 900g Caulis Sargentodoxae 900g Radix Glycyrrhizae 90g
Folium Isatidis 90g Herba Taraxaci 270g Radix Paeoniae Rubra 270g
Radix Et Rhizoma Rhei (system) 180g Radix Salviae Miltiorrhizae 270g Rhizoma Polygoni Cuspidati 270g
Fructus Toosendan (system) 270g Rhizoma Corydalis (system) 270g
Mel (refining) 1000g
Make 1000 balls
Preparation method: above ten simply, and Rhizoma Corydalis (system) is ground into fine powder, and is standby.Radix Salviae Miltiorrhizae, Radix Paeoniae Rubra, Rhizoma Polygoni Cuspidati add ethanol, the heating and refluxing extraction secondary, and each 2 hours, merge extractive liquid, filtered, and filtrate recycling ethanol also is concentrated into the thick paste that relative density is 1.36 (60 ℃), and is standby.Seven flavors such as medicinal residues and all the other Caulis Loniceraes decoct with water three times, 2 hours for the first time, 1.5 hours for the second time, 1 hour for the third time, collecting decoction, filter, filtrate decompression is concentrated into the thick paste that relative density is 1.36 (60 ℃), and with above-mentioned thick paste and Rhizoma Corydalis fine powder mix homogeneously, (60～80 order) sieves, add refined honey, and water pill, drying is made water-honeyed pill.(the heavy 2.0g of every ball)
Embodiment 4:
The preparation method of granule of the present invention:
Caulis Lonicerae 450g Caulis Sargentodoxae 450g Radix Glycyrrhizae 45g
Folium Isatidis 45g Herba Taraxaci 135g Radix Paeoniae Rubra 135g
Radix Et Rhizoma Rhei (system) 90g Radix Salviae Miltiorrhizae 135g Rhizoma Polygoni Cuspidati 135g
Fructus Toosendan (system) 135g Rhizoma Corydalis (system) 135g
Sodium carboxymethyl cellulose 50g
Icing Sugar 3030g dextrin 1500g
The 5%PVP75% alcoholic solution is an amount of
Make 1000 bags
Preparation method: above ten simply, and Rhizoma Corydalis (system) is ground into fine powder, and is standby.Radix Salviae Miltiorrhizae, Radix Paeoniae Rubra, Rhizoma Polygoni Cuspidati add ethanol, the heating and refluxing extraction secondary, and each 2 hours, merge extractive liquid, filtered, and filtrate recycling ethanol also is concentrated into the thick paste that relative density is 1.36 (60 ℃), and is standby.Seven flavors such as medicinal residues and all the other Caulis Loniceraes decoct with water three times, 2 hours for the first time, 1.5 hours for the second time, 1 hour for the third time, collecting decoction, filter, filtrate decompression is concentrated into the thick paste that relative density is 1.36 (60 ℃), with above-mentioned thick paste and Rhizoma Corydalis fine powder mix homogeneously, (60～80 order) sieves, add Icing Sugar, dextrin, sodium carboxymethyl cellulose,, put in 70 ℃ of vacuum drying ovens dry with 5%PVP75% alcoholic solution 14 mesh sieve system soft materials, 12 mesh sieve granulate, pack promptly.(every bag heavy 5.0g).
Claims (9)
1. a compound Chinese medicinal preparation for the treatment of gynecological inflammation is characterized in that, per 1000 dosage units are made by the raw material of Chinese medicine of following weight parts:
45 parts in 450 portions of Radix Glycyrrhizaes of 450 portions of Caulis Sargentodoxae of Caulis Lonicerae
135 parts of 135 parts of Radix Paeoniae Rubra of 45 parts of Herba Taraxacis of Folium Isatidis
135 parts of 135 parts of Rhizoma Polygoni Cuspidati of 90 parts of Radix Salviae Miltiorrhizaes of Radix Et Rhizoma Rhei (system)
135 parts of 135 parts of Rhizoma Corydalis of Fructus Toosendan (system) (system)
2. the compound Chinese medicinal preparation of claim 1 is comprising the medicine acceptable carrier.
3. claim 2 Chinese medicine acceptable carrier comprises filler, binding agent, disintegrating agent, lubricant, correctives.
4. the described filler of claim 3 is selected from starch, Icing Sugar, dextrin, microcrystalline Cellulose, lactose, amylum pregelatinisatum, mannitol, calcium hydrogen phosphate; Binding agent is selected from starch slurry, polyvinylpyrrolidone aqueous solution or alcoholic solution, gelling starch, sodium carboxymethyl cellulose solution, water, Mel or water-honey liquor; Disintegrating agent is selected from carboxymethyl starch sodium, low-substituted hydroxypropyl cellulose, crospolyvinylpyrrolidone, cross-linking sodium carboxymethyl cellulose; Lubricant is selected from magnesium stearate, Macrogol 4000 or polyethylene glycol 6000, Pulvis Talci, sodium lauryl sulphate, micropowder silica gel; Correctives is selected from aspartame, flavoring orange essence, Herba Menthae essence etc.
5. the compound Chinese medicinal preparation of claim 1 is capsule, tablet, granule or pill.
6. the preparation method of the compound Chinese medicinal preparation of claim 5 is characterized in that, through following steps,
(1) get recipe quantity Rhizoma Corydalis (system) and be ground into fine powder, standby;
(2) get recipe quantity Radix Salviae Miltiorrhizae, Radix Paeoniae Rubra, Rhizoma Polygoni Cuspidati and add ethanol, the heating and refluxing extraction secondary, each 2 hours, merge extractive liquid, filtered, and filtrate recycling ethanol also is concentrated into the thick paste that relative density is 1.36 (60 ℃);
(3) seven flavors such as the Caulis Lonicerae of medicinal residues and all the other recipe quantities decoct with water three times, and 2 hours for the first time, 1.5 hours for the second time, 1 hour for the third time, collecting decoction filtered, and filtrate decompression is concentrated into the thick paste that relative density is 1.36 (60 ℃);
(4) thick paste and the Rhizoma Corydalis fine powder mix homogeneously that (2) and (3) are made, vacuum drying is pulverized, and the starch slurry 24 mesh sieve system soft materials with 10% are put 70 ℃ of vacuum dryings, and 20 mesh sieve granulate incapsulate shell, make medicine capsule of the present invention.
7. the preparation method of the compound Chinese medicinal preparation of claim 5 is characterized in that, through following steps,
1) get recipe quantity Rhizoma Corydalis (system) and be ground into fine powder, standby;
(2) get recipe quantity Radix Salviae Miltiorrhizae, Radix Paeoniae Rubra, Rhizoma Polygoni Cuspidati and add ethanol, the heating and refluxing extraction secondary, each 2 hours, merge extractive liquid, filtered, and filtrate recycling ethanol also is concentrated into the thick paste that relative density is 1.36 (60 ℃);
(3) seven flavors such as the Caulis Lonicerae of medicinal residues and all the other recipe quantities decoct with water three times, and 2 hours for the first time, 1.5 hours for the second time, 1 hour for the third time, collecting decoction filtered, and filtrate decompression is concentrated into the thick paste that relative density is 1.36 (60 ℃);
(4) thick paste and the Rhizoma Corydalis fine powder mix homogeneously that (2) and (3) are made, add 6.67 parts of carboxymethyl starch sodium, with an amount of 10% polyvidone alcoholic solution system, 24 mesh sieve soft materials, put drying in 70 ℃ of vacuum drying ovens, 20 mesh sieve granulate, add 3.33 parts of carboxymethyl starch sodium again, 5 parts of magnesium stearate, mix homogeneously, tabletting, coating, promptly.
8. the preparation method of the compound Chinese medicinal preparation of claim 5 is characterized in that, through following steps,
1) get recipe quantity Rhizoma Corydalis (system) and be ground into fine powder, standby;
(2) get recipe quantity Radix Salviae Miltiorrhizae, Radix Paeoniae Rubra, Rhizoma Polygoni Cuspidati and add ethanol, the heating and refluxing extraction secondary, each 2 hours, merge extractive liquid, filtered, and filtrate recycling ethanol also is concentrated into the thick paste that relative density is 1.36 (60 ℃);
(3) seven flavors such as the Caulis Lonicerae of medicinal residues and all the other recipe quantities decoct with water three times, and 2 hours for the first time, 1.5 hours for the second time, 1 hour for the third time, collecting decoction filtered, and filtrate decompression is concentrated into the thick paste that relative density is 1.36 (60 ℃);
(4) thick paste and the Rhizoma Corydalis fine powder mix homogeneously that (2) and (3) are made, (60～80 order) sieves, add 50 parts of 3030 parts of Icing Sugar, dextrin 1500, sodium carboxymethyl cellulose, with an amount of 5%PVP75% alcoholic solution 14 mesh sieve system soft materials, put in 70 ℃ of vacuum drying ovens dry, 12 mesh sieve granulate, pack makes medicinal granule of the present invention.
9. the preparation method of the compound Chinese medicinal preparation of claim 5 is characterized in that, through following steps,
(1) get recipe quantity Rhizoma Corydalis (system) and be ground into fine powder, standby;
(2) get recipe quantity Radix Salviae Miltiorrhizae, Radix Paeoniae Rubra, Rhizoma Polygoni Cuspidati and add ethanol, the heating and refluxing extraction secondary, each 2 hours, merge extractive liquid, filtered, and filtrate recycling ethanol also is concentrated into the thick paste that relative density is 1.36 (60 ℃);
(3) seven flavors such as the Caulis Lonicerae of medicinal residues and all the other recipe quantities decoct with water three times, and 2 hours for the first time, 1.5 hours for the second time, 1 hour for the third time, collecting decoction filtered, and filtrate decompression is concentrated into the thick paste that relative density is 1.36 (60 ℃);
(4) thick paste and the Rhizoma Corydalis fine powder mix homogeneously that (2) and (3) are made, sieve (60～80 order) adds 1000 parts of refined honeys and water pill, and drying is made bolus of drug of the present invention.
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| CN 200510097960 CN1765382A (en) | 2005-09-02 | 2005-09-02 | Chinese medicinal compound formulation for treating gynecological inflammation and its preparation method |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101057894B (en) * | 2006-04-21 | 2010-05-12 | 北京因科瑞斯生物制品研究所 | A kind of traditional Chinese medicine preparation for gynecology and preparation method thereof |
| CN102600399A (en) * | 2012-03-29 | 2012-07-25 | 常熟市常福有机复合肥有限公司 | Traditional Chinese medicine for treating chronic annex inflammatory mass and preparation method of traditional Chinese medicine |
| CN102805782A (en) * | 2012-08-16 | 2012-12-05 | 杨凌东科麦迪森制药有限公司 | Preparation method of fuyanshu capsule |
| CN103656383A (en) * | 2013-12-27 | 2014-03-26 | 庄彩梅 | Traditional Chinese medicine for treating pelvic inflammatory disease and preparation method thereof |
| CN106692102A (en) * | 2017-01-11 | 2017-05-24 | 恒拓集团广西圣康制药有限公司 | Liver clearing and toxin removing tablets and preparation method |
| CN106692089A (en) * | 2017-01-11 | 2017-05-24 | 恒拓集团广西圣康制药有限公司 | Gynecologic inflammation relieving tablets and preparation method thereof |
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2005
- 2005-09-02 CN CN 200510097960 patent/CN1765382A/en active Pending
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101057894B (en) * | 2006-04-21 | 2010-05-12 | 北京因科瑞斯生物制品研究所 | A kind of traditional Chinese medicine preparation for gynecology and preparation method thereof |
| CN102600399A (en) * | 2012-03-29 | 2012-07-25 | 常熟市常福有机复合肥有限公司 | Traditional Chinese medicine for treating chronic annex inflammatory mass and preparation method of traditional Chinese medicine |
| CN102805782A (en) * | 2012-08-16 | 2012-12-05 | 杨凌东科麦迪森制药有限公司 | Preparation method of fuyanshu capsule |
| CN103656383A (en) * | 2013-12-27 | 2014-03-26 | 庄彩梅 | Traditional Chinese medicine for treating pelvic inflammatory disease and preparation method thereof |
| CN106692102A (en) * | 2017-01-11 | 2017-05-24 | 恒拓集团广西圣康制药有限公司 | Liver clearing and toxin removing tablets and preparation method |
| CN106692089A (en) * | 2017-01-11 | 2017-05-24 | 恒拓集团广西圣康制药有限公司 | Gynecologic inflammation relieving tablets and preparation method thereof |
| CN106692089B (en) * | 2017-01-11 | 2020-05-12 | 恒拓集团广西圣康制药有限公司 | Fuyanshu tablet and its preparation method |
| CN106692102B (en) * | 2017-01-11 | 2020-06-30 | 恒拓集团广西圣康制药有限公司 | Liver-clearing and detoxifying tablet and preparation method thereof |
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