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CN1761464A - 被取代的对－二氨基苯衍生物 - Google Patents

被取代的对－二氨基苯衍生物 Download PDF

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Publication number
CN1761464A
CN1761464A CNA2004800075074A CN200480007507A CN1761464A CN 1761464 A CN1761464 A CN 1761464A CN A2004800075074 A CNA2004800075074 A CN A2004800075074A CN 200480007507 A CN200480007507 A CN 200480007507A CN 1761464 A CN1761464 A CN 1761464A
Authority
CN
China
Prior art keywords
alkene
base
amino
phenyl
chloro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CNA2004800075074A
Other languages
English (en)
Chinese (zh)
Inventor
N·汉津
M·罗特莱恩德
A·里岑
W·P·沃特森
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
H Lundbeck AS
Original Assignee
H Lundbeck AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=58707221&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CN1761464(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by H Lundbeck AS filed Critical H Lundbeck AS
Publication of CN1761464A publication Critical patent/CN1761464A/zh
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/42—Radicals substituted by singly-bound nitrogen atoms having hetero atoms attached to the substituent nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/58—Radicals substituted by nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CNA2004800075074A 2003-03-21 2004-03-18 被取代的对－二氨基苯衍生物 Pending CN1761464A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA200300441 2003-03-21
DKPA200300441 2003-03-21

Publications (1)

Publication Number Publication Date
CN1761464A true CN1761464A (zh) 2006-04-19

Family

ID=58707221

Family Applications (1)

Application Number Title Priority Date Filing Date
CNA2004800075074A Pending CN1761464A (zh) 2003-03-21 2004-03-18 被取代的对－二氨基苯衍生物

Country Status (9)

Country Link
KR (1) KR20050115919A (uk)
CN (1) CN1761464A (uk)
AR (1) AR043652A1 (uk)
CL (1) CL2004000575A1 (uk)
EA (1) EA200501499A1 (uk)
IS (1) IS7991A (uk)
NZ (1) NZ541945A (uk)
UA (1) UA81019C2 (uk)
ZA (1) ZA200507183B (uk)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103073455A (zh) * 2011-10-25 2013-05-01 中国科学院上海药物研究所 一类新型的kcnq钾通道激动剂、其制备方法和用途
CN105017085A (zh) * 2014-04-28 2015-11-04 中国科学院上海药物研究所 一类新型的kcnq钾通道激动剂、其制备方法和用途
CN108707087A (zh) * 2018-06-29 2018-10-26 河北医科大学 一种4-（对三氟甲基苄基）-3-氟-1,2,4三苯胺衍生物及其药物组合物与用途

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102643653B1 (ko) * 2020-11-13 2024-03-06 기초과학연구원 신규한 아미노방향족 화합물 또는 이의 약학적으로 허용가능한 염 및 이를 유효성분으로 포함하는 신경퇴행성 질환의 예방 또는 치료용 약학적 조성물
CN114672483B (zh) * 2022-05-31 2022-09-02 上海百力格生物技术有限公司 超声法核酸探针制备方法
KR20250051019A (ko) * 2023-10-06 2025-04-16 기초과학연구원 허혈성 뇌혈관 질환 및 이의 후유증의 치료를 위한 화합물 및 이를 포함하는 조성물

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9353048B2 (en) 2011-10-25 2016-05-31 Shanghai Institute Of Materia Medica, Chinese Academy Of Sciences Compound as KCNQ potassium channel agonist, preparation method therefor and use thereof
WO2013060097A1 (zh) * 2011-10-25 2013-05-02 中国科学院上海药物研究所 一类可用作kcnq钾通道激动剂的新型化合物、其制备方法和用途
CN103073455B (zh) * 2011-10-25 2015-08-19 中国科学院上海药物研究所 一类新型的kcnq钾通道激动剂、其制备方法和用途
CN103073455A (zh) * 2011-10-25 2013-05-01 中国科学院上海药物研究所 一类新型的kcnq钾通道激动剂、其制备方法和用途
CN105017085B (zh) * 2014-04-28 2018-06-29 中国科学院上海药物研究所 一类kcnq钾通道激动剂、其制备方法和用途
WO2015165352A1 (zh) * 2014-04-28 2015-11-05 中国科学院上海药物研究所 一类新型的kcnq钾通道激动剂、其制备方法和用途
CN105017085A (zh) * 2014-04-28 2015-11-04 中国科学院上海药物研究所 一类新型的kcnq钾通道激动剂、其制备方法和用途
US10077245B2 (en) 2014-04-28 2018-09-18 Shanghai Institute Of Materia Medica, Chinese Academy Of Sciences KCNQ potassium channel agonists, method of preparation and method of use thereof
US10316008B2 (en) 2014-04-28 2019-06-11 Shanghai Institute Of Materia Medica, Chinese Academy Of Sciences KCNQ potassium channel agonist, and preparation method therefor and use thereof
CN108707087A (zh) * 2018-06-29 2018-10-26 河北医科大学 一种4-（对三氟甲基苄基）-3-氟-1,2,4三苯胺衍生物及其药物组合物与用途
WO2020001298A1 (zh) * 2018-06-29 2020-01-02 河北医科大学 一种4-(对三氟甲基苄基)-3-氟-1,2,4三苯胺衍生物及其药物组合物与用途
CN108707087B (zh) * 2018-06-29 2020-10-16 河北医科大学 一种4-(对三氟甲基苄基)-3-氟-1,2,4三苯胺衍生物及其药物组合物与用途
US11247966B2 (en) 2018-06-29 2022-02-15 Hebei Medical University 4-(p-trifluoromethylbenzyl)-3-fluoro-1,2,4-triphenylamine derivative and pharmaceutical composition and applications thereof

Also Published As

Publication number Publication date
EA200501499A1 (ru) 2006-02-24
AR043652A1 (es) 2005-08-03
KR20050115919A (ko) 2005-12-08
ZA200507183B (en) 2007-03-28
NZ541945A (en) 2009-02-28
UA81019C2 (en) 2007-11-26
IS7991A (is) 2005-08-18
CL2004000575A1 (es) 2005-01-21

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