CN1743004A - Compound preparation for anti-pregnancy by killing sperm and sterilizing, preparation method thereof - Google Patents

Abstract

The invention relates to a compound preparation for vaginal administration of sterilization and spermicide and anti-pregnancy and a preparation method thereof, including broad-spectrum antibacterial agent, anti-pregnancy spermicide, water and a medically acceptable amount of auxiliary materials, and its preparation The method comprises mixing and stirring water, monomer carrier, surface active agent and dispersant under normal temperature condition, adding broad-spectrum antibacterial agent and anti-pregnancy spermicide, stirring evenly, and subpackaging. The sterilizing and spermicidal anti-pregnancy compound preparation for vaginal administration of the invention is safe and effective, has the functions of contraception, antibacterial and lubricating, is convenient to use, and has little toxic and side effects.

Description

A compound preparation for spermicide, anti-pregnancy and sterilization and its preparation method

technical field

The invention relates to a compound preparation for spermicide, anti-pregnancy and sterilization, in particular to a gel for spermicide, anti-pregnancy and sterilization and a preparation method thereof.

Background technique

Family planning is the basic national policy of the country, and the improvement and popularization of family planning appliances and equipment is an important technical support for the realization of this national policy. The development of safe, effective, simple, less side effects, beneficial to reproductive health, and the masses are willing to accept Family planning appliances and devices are the development trend of family planning products.

Currently commonly used contraceptive methods are oral contraceptives and external barrier contraception. Condoms, vaginal diaphragms, cervical caps, contraceptive sponges, and birth control all have certain deficiencies in use. Oral contraceptives often have endocrine-interfering effects and cause nausea. , vomiting, and even irregular vaginal bleeding and other side effects limit its scope of use; condoms are currently the most widely used male contraceptive tool, but some people may experience allergic reactions or discomfort, and the rupture rate is reported at 1%-12% The rate of slippage during sexual intercourse is 6%. The vaginal diaphragm is a soft rubber cap that is put into the vagina before intercourse and covers the cervix and posterior fornix. However, because the edge of the diaphragm cannot be tightly sealed with the vaginal wall, the failure rate is 1.6%. It varies from 9.8%; the cervical cap is a rubber barrier contraceptive tool similar to the diaphragm, and the doctor must choose the size and guide the application method during application, and the failure rate is 5%-18%; the contraceptive sponge is a spermicide It is a circular elastic block made of polyurethane material, which has the functions of absorbing semen, immobilizing sperm and barrier contraception, but there are reports of toxic shock syndrome caused by vaginal sponge fragments remaining in the vagina.

Contents of the invention

The object of the present invention is to provide a compound preparation for spermicide, anti-pregnancy and sterilization, which has remarkable contraceptive effect, is convenient to use and has little toxic and side effects.

Another object of the present invention is to provide a compound preparation for spermicide, anti-pregnancy and sterilization and its preparation method.

In order to achieve the above object, the compound preparation for spermicide, anti-pregnancy and sterilization provided by the present invention includes the components of the following parts by weight:

Broad-spectrum antibacterial agent 0.01-50, anti-pregnancy spermicide 2-20.

Preferably, the following components by weight are included:

Broad-spectrum antibacterial agent 15-50, anti-pregnancy spermicide 2-20.

Preferably, the following components by weight are included:

Broad-spectrum antibacterial agent 0.01-0.1, anti-pregnancy spermicide 2-20.

Most preferably, the compound preparation also includes the following components in parts by weight:

Water 90-750 and medically acceptable amount of auxiliary materials.

The broad-spectrum antibacterial agent is one or a mixture of nanometer silver, benzalkonium chloride, benzalkonium bromide, chlorhexidine acetate, and triclosan.

The particle diameter of the nano-silver is 1-100 nanometers.

The anti-pregnancy spermicide is one of octoxynol, nonoxynol ether, alkanol ether, menthoxynol ether and benzalkonium chloride or a mixture of several of them.

The auxiliary material is one or a mixture of monomer carriers, surfactants and dispersants.

The weight ratio of described auxiliary material:

Monomer carrier 15-815 Surfactant 50-140 Dispersant 45-350;

Described monomer carrier is carbomer, sodium carboxymethylcellulose (CMC-Na), polyvinylpyrrolidone (PVP), polyvinyl alcohol (PVA), polyethylene glycol-400, polyethylene glycol-3350 one or a mixture of several of them.

Described tensio-active agent is sodium lauryl sulfate, stearic acid, stearyl alcohol, sodium dodecyl sulfate (AS), sodium dodecyl sulfate (SDS), cetyl trimethyl bromide Ammonium (CTAB), α-monoalkyl glyceryl ether (GE), polyoxyethylene polyoxypropylene copolyether, polyglycerol-polybutylene fatty alcohol ether (PGT alkyl ether), fructoside, butyl stearate, One or a mixture of isopropanol isostearate, polyvinylpyrrolidone, sodium lauryl dimethyl acetate (BS-12), alkyl amidopropyl betaine, and alkyl imidazoline .

The dispersant is one or a mixture of glycerol, propylene glycol, sodium lauryl sulfate and triethanolamine.

The compound preparation is a gel.

A method for preparing a compound preparation for sterilizing, disinfecting and spermicidal anti-pregnancy vaginal administration, comprising: mixing and stirring water, a monomer carrier, a surfactant, and a dispersant evenly under normal temperature conditions, adding broad-spectrum antibacterial agents, anti-pregnancy Stir the essence evenly and divide into packages.

Another method for preparing a sterilizing and spermicidal anti-pregnancy compound preparation for vaginal administration includes: mixing and stirring water, monomer carriers, surfactants, and dispersants evenly at room temperature, adding broad-spectrum antibacterial agents, anti-pregnancy Stir the essence evenly, add stearic acid and/or stearyl alcohol under the condition of heating and stirring at 60-90°C, mix evenly, cool to solidify under stirring, and pack separately.

Yet another method for preparing the compound preparation for vaginal administration of sterilization, sterilization and spermicide and anti-pregnancy, including:

Dissolve the broad-spectrum antibacterial agent and anti-pregnancy spermicide in water under normal temperature conditions; add carbomer to glycerol and grind to make it wet and partially swell, the swelling degree of carbomer is 40-60%, add water to make it Absorb water and swell until it becomes a translucent gel, then dissolve the dispersant in water and add the above gel, grind it into a thick and transparent gel matrix, add the above broad-spectrum antibacterial agent, anti-pregnancy spermicide solution, and grind Evenly, divide into packs.

Usage and Dosage:

Use one before intercourse.

Tear open the package before use, and take out the vaginal applicator loaded with nano-silver contraceptive gel;

Remove the front cover of the vaginal applicator, and insert it into the rear end of the vaginal applicator as a booster rod; adopt the supine position, bend the knees, open the legs as much as possible, insert the vaginal applicator slow ring into the deep vagina, and push it with the index finger With the aid of the rod, push the nano-silver contraceptive gel fully into the depth, and then slowly pull it out.

The sterilizing and spermicidal anti-pregnancy compound preparation for vaginal administration of the invention is safe and effective, has the functions of contraception, antibacterial and lubricating, is convenient to use, and has little toxic and side effects. Clinical data show that the compound bactericidal contraceptive gel acts for 2 minutes and 20 minutes under the test conditions, and the bacteriostatic rates against Escherichia coli are 93.8% and 98.3% respectively; the bacteriostatic rates against Staphylococcus aureus are 97.9% and 99.3% respectively. %; the antibacterial rates against Streptococcus albicans were 95.0% and 97.2%, respectively, indicating a strong antibacterial effect. At a dilution of 1:6, the sperm inactivation rate of the compound bactericidal contraceptive gel reaches 100% within 1 minute; at a dilution of 1:30, the sperm inactivation rate reaches 100% within 1 minute; at 1:60 At a certain dilution, the sperm inactivation rate reaches 79.00±3.92% within 1 minute; the sperm inactivation rate reaches 100% within 5 minutes. The barrier sperm test showed an average sperm inactivation rate of 98.2% within 5 seconds and an average sperm inactivation rate of 100% within 1 minute.

Unless otherwise specified, the formula of the compound bactericidal anti-pregnancy gel in the following tests is:

Nano silver 0.1kg octoxynol 20kg

Polyethylene Glycol-400 90kg Glycerol 200kg

Carbomer 940 15g Triethanolamine 150g

Sodium Lauryl Sulfate 3.0kg Macrogol-3350 50kg

Purified water 471.9kg

Made 1000kg

                           

The antibacterial test was tested by the Guangzhou Center for Disease Control and Prevention: it was carried out according to the provisions of Appendix C of GB15979-2002 "(Sanitary Standards for Disposable Sanitary Products"). The antibacterial rates to Escherichia coli were 93.8%, 98.3%; the antibacterial rates to Staphylococcus aureus were 97.9%, 99.3%; the antibacterial rates to Streptococcus albicans were 95.0%, 97.2%; Strong antibacterial effect. See Table 1.

Reagents used in the test group: compound bactericidal anti-pregnancy gel (see lines 20-29 on page 3 of the instruction manual);

The reagents used in the control group:

Escherichia coli: sterile sodium chloride-peptone buffer + Escherichia coli (8099);

Staphylococcus aureus: sterile sodium chloride-peptone buffer + Staphylococcus aureus (ATCC6538);

Candida albicans: sterile sodium chloride-peptone buffer + Candida albicans (ATCC10231).

Table 1: Antibacterial test results Test strain Action concentration Action time (min) The average number of surviving bacteria in the test group (cfu/ml) The average number of surviving bacteria in the control group (cfu/ml) Bacteriostatic rate (%) Escherichia coli 8099 stock solution 251020 4.2×1033.4×1032.8×1032.5×103 6.8×1046.9×1047.2×1047.8×104 93.895.196.198.3 Staphylococcus aureus ATCC6538 stock solution 251020 1.1×1030.8×1030.7×1030.4×103 5.3×1045.6×1045.5×1045.7×104 97.998.698.799.3 Candida albicans ATCC10231 stock solution 251020 2.9×1032.8×1031.8×1031.6×103 5.7×1045.8×1045.4×1045.7×104 95.094.896.897.2

Spermicidal effect test

The in vitro spermicidal test was tested by the Institute of Science and Technology of the National Family Planning Commission: it was carried out according to the method in the "WHO Human Semen and Sperm-Cervical Mucus Interaction Test Manual". Under the dilution, the sperm inactivation rate reaches 100% within 1 minute; at the 1:30 dilution, the sperm inactivation rate reaches 100% within 1 minute; at the 1:60 dilution, the sperm inactivation rate reaches 1 minute The rate reached 79.00±3.92%; the sperm inactivation rate reached 100% within 5 minutes. See Table 2.

Table 2: Detection of the ability of the compound bactericidal anti-pregnancy gel stock solution to act on human sperm stock solution dilution ratio Human sperm mortality rate (%) and action time (min) 0～1min 0～5min 1:61:301:60 control (BWW) 10010079.00±3.92- --10025.40±10.5

Note: compound bactericidal anti-pregnancy gel (see lines 20-29 on page 3 of the instruction manual)

Barrier sperm test

In vitro barrier human sperm test (conducted by the Third Affiliated Hospital of Zhongshan Medical University): with reference to the Sander-Ceamer method recommended by WHO, the test results show that the sperm inactivation rate in the experimental group is significantly improved within 5 seconds compared with the blank group, and there is Significant statistical significance P<0.001, the sperm survival rate decreased significantly after 1 minute to 30 minutes; the sperm inactivation rate in test group 2 was judged by 0.1% eosin staining solution sperm staining within 5 seconds on average 98.2%, within 1 minute The sperm inactivation rate was 100% on average, which was significantly improved compared with the blank, with a statistical difference P<0.001. See Table 3.

Reagents used in the test group: nano-silver aqueous solution, the concentration is 20ppm;

Reagent used in test group 2: compound bactericidal anti-pregnancy gel (see lines 20-29 on page 3 of the instruction manual);

Reagent used in blank group: liquefied semen

Table 3: Results of In Vitro Barrier Human Sperm Test group Number of specimens test results Average ratio % 5 seconds 1min 10min 30min Test group I (without octoxynol) gel II (with octoxynol) blank group (liquefied semen) 202020 inactivation rate inactivation rate inactivation rate 93.298.20.1 97.2100.00.1 100.0100.00.2 100.0100.04.0

A clinical study on the reliability and practicability of killer sperm

Clinical trial: The clinical research on the reliability and practicability of the compound bactericidal anti-pregnancy gel in killing sperm (Renji Hospital Affiliated to Shanghai Second Medical University) showed that all 32 pairs of subjects in this group completed the test, and none fell out. After masturbation to collect semen, it was found that the semen volume was 2.1±0.3ml, the sperm density was 74.54±10.25×10 ⁶ /ml, and the average motility rate of sperm was 70.64±15.1%. Observing the sperm and eosin staining under the high power field of the microscope found that: after using for 30min-1h, there was no viable sperm in the posterior fornix of the woman in 30 couples, no motile sperm in the cervical mucus of 31 cases, and the sperm inactivation rate was 97.0%. In one case, 30 minutes and 2 hours after use, there were still motile sperm in the cervical millet fluid, and the percentage of viable sperm was 3%. Investigating its method of use found that the dosage was too small, and the product was not injected into the vagina to the required depth. During the test, all the couples in all groups had no serious adverse reactions such as penis, vaginal edema or erosion during and after sexual intercourse. Two cases of women had mild vaginal burning sensation after using it, but it was tolerable, and the burning sensation disappeared within about 10 minutes. Comparing the percentage of live sperm when taking the compound bactericidal anti-pregnancy gel within 30min-1h with the man's masturbation, the difference in the percentage of live sperm under the high-power field of view is very significant, and the statistical processing is P<0.01. Vaginal specimen smear, leucorrhea routine, vaginal pH and vaginal bacilli culture, compared with those after 24 hours of using the compound anti-pregnancy gel, there was no statistically significant difference, P>0.05. There was no gel residue after 24 hours Among the 32 couples, 30 couples were satisfied with the contraceptive and vaginal lubrication effects of this product, and the satisfaction rate was 93.8%.

The summary of the clinical trials of nano-silver contraceptive gel (Family Planning Research Institute of Tongji Medical College, Huazhong University of Science and Technology) showed that no motile sperm was found in the lower vagina of 25 subjects during the entire test period. In the remaining 5 subjects, the motile sperm were mainly concentrated 1 minute after intercourse, and the sperm were graded as b and c grades, and no a grade sperm was seen. After 5 minutes, only two subjects found motile sperm, and after 10 minutes, all motile sperm were immobilized.

Compound bactericidal anti-pregnancy gel (see lines 20-29 on page 3 of the instruction manual)

Comparison of antibacterial test effects of compound nano-silver octoxynyl polyol gel

Nanosilver group; Octoxynol group; compound bactericidal anti-pregnancy gel (detected by Guangzhou Center for Disease Control and Prevention): according to the provisions of Appendix C of GB15979-2002 "Hygienic Standards for Disposable Sanitary Products", the test results show that: The compound bactericidal and anti-pregnancy gel acted for 2 minutes and 20 minutes under the test conditions, and the bacteriostatic rates against Escherichia coli were 94.7% and 98.0% respectively; were 92.5%, 96.0% respectively; the octoxynol group acted under test conditions for 2min, 20min, and the bacteriostatic rates to Escherichia coli were respectively 85.3%, 90.2%; The antibacterial effect of the nano-silver group was better, followed by that of the octoxynol group. See Table 4.

The compound bactericidal anti-pregnancy gel group used compound bactericidal anti-pregnancy gel (see lines 20-29 on page 3 of the instruction manual);

The nano-silver group uses a nano-silver aqueous solution with a concentration of 20ppm;

What octoxynyl alcohol used is octoxynyl alcohol, and the weight percent concentration is 2%;

Table 4: In vitro antibacterial test results of three groups against Escherichia coli group Action concentration Action time (min) The average number of surviving bacteria in the test group (cfu/ml) The average number of surviving bacteria in the control group (cfu/ml) Bacteriostatic rate (%) Compound bactericidal anti-pregnancy gel group stock solution 251020 4.0×1033.1×1032.5×1031.5×103 7.6×1047.2×1047.0×1047.6×104 94.795.796.498.0 nano silver group 20ppm 251020 4.8×1033.9×1032.9×1032.8×103 6.4×1046.8×1047.0×1047.0×104 92.594.295.896.0 Octoxynol group 2% 251020 9.8×1039.2×1037.6×1037.4×103 6.7×1047.2×1047.4×1047.6×104 85.387.289.790.2

Comparison of in vitro spermicidal effects among nano silver group, compound bactericidal anti-pregnancy gel and octoxynol group

Nano-silver group, compound bactericidal anti-pregnancy gel group; the comparison of the in vitro spermicidal effect of the octoxynol group (by the Third Affiliated Hospital of Zhongshan Medical University): with reference to the Sander-Ceamer method recommended by WHO, the test results show that: Ridit analysis shows that the R value of the compound bactericidal anti-pregnancy gel group is 0.620, the R value of the octoxynol group is 0.495, and the R value of the nano-silver group is 0.3210. In the 95% credible interval, the nano-silver invisible condom The credible interval of the octoxynol group is 0.531-0.693, the credible interval of the octoxynol group is 0.380-0.595, and the credible interval of the nano-silver group is 0.228-0.44z6. The three groups have different spermicidal effects. The R value of the compound nano-silver octoxynyl polyol gel group > the R value of the octoxynyl polyol group > the R value of the nano-silver group. Compared among the three, the spermicidal effect of the compound nano-silver octoxynyl polyol gel group was better, and the octoxynyl polyol gel group had a better spermicidal effect. The polyalcohol group is next, followed by the nano-silver group. See Table 5.

The compound bactericidal anti-pregnancy gel group used compound bactericidal anti-pregnancy gel (see lines 20-29 on page 3 of the instruction manual);

The nano-silver group uses a nano-silver aqueous solution with a concentration of 20ppm;

What octoxynyl alcohol used is an aqueous solution of octoxynyl alcohol, and the weight percent concentration is 2%;

Table 5: Three groups of in vitro killer sperm test results group Number of specimens test results Octoxynol group Compound bactericidal anti-pregnancy gel group Nano silver group 202020 Average ratio % inactivation rate inactivation rate inactivation rate 5 seconds 90.799.272.9 1 minute 93.7100.078.6 10 minutes 100.0100.084.5 30 minutes 100.0100.095.4

Detailed ways

Example 1

Nano Silver 0.07kg Octoxynol 15kg Carbomer 15kg

Polyethylene glycol-3350 30kg Polyethylene glycol-400 50kg Sodium lauryl sulfate 0.5kg

Glycerol 200kg Triethanolamine 150kg Distilled water 550kg

The particle size of nano silver is 50 nanometers;

Preparation method: Dissolve nano-silver, octoxynyl alcohol, sodium lauryl sulfate, polyethylene glycol-400, polyethylene glycol-3350 in 150kg of distilled water at room temperature; add carbomer to glycerol and grind Make it wet and partially swell, the swelling degree of carbomer is 60%, add 350kg distilled water to make it absorb water and swell fully until it becomes a translucent gel, then dissolve triethanolamine in 50kg distilled water and add the above gel, grind until it becomes thick Thick and transparent gel matrix, add the above-mentioned nano-silver and octoxynyl polyalcohol solution, grind it evenly, and pack it separately.

Example 2

Nano Silver 0.01kg Nonoxynol 13kg Sodium Carboxymethyl Cellulose 10kg

Polyethylene glycol-400 300kg Polyethylene glycol-3350 400kg Stearic acid 50kg

Sodium dodecyl sulfonate 0.5kg Triethanolamine 15kg Propylene glycol 65kg

Deionized water 146.42kg

The particle size of nano silver is 1 nanometer;

Preparation method: Mix and stir deionized water, sodium carboxymethylcellulose, sodium dodecylsulfonate, triethanolamine, propylene glycol, polyethylene glycol-400, and polyethylene glycol-3350 according to the prescription amount at room temperature , add nano-silver and nonoxynol ether and stir evenly, add stearic acid under the condition of 60°C and put it in a homogenizer to mix evenly, cool to solidify under stirring, and pack it separately.

Example 3

Nanosilver 0.1kg Menthoxylin Ether 17kg Polyethylene Glycol-3350 200kg

Polyethylene glycol-400 400kg Polyvinylpyrrolidone 15kg Stearic acid 14.5kg

Stearyl Alcohol 35kg Sodium Lauryl Sulfate 0.5kg Triethanolamine 20kg

Glycerol 45kg Distilled water 300kg

The particle size of nano silver is 100 nanometers;

Preparation method: Mix distilled water, polyvinylpyrrolidone, sodium lauryl sulfate, triethanolamine, glycerol, polyethylene glycol-400, polyethylene glycol-3350 according to the prescription amount at room temperature and stir evenly, add nano-silver , octoxynyl alcohol, stir evenly, add stearic acid and stearyl alcohol under the condition of heating and stirring at 75°C, and finally put it in a homogenizer to mix evenly, cool to solidify under stirring, and pack it separately.

Example 4

Benzalkonium Chloride 15kg Benzalkonium Chloride 20kg Polyvinyl Alcohol 50kg

Cetyltrimethylammonium Bromide 50kg α-Monoalkylglycerol Ether 60kg

Glycerol 55kg Deionized water 750kg

Preparation method: Mix and stir deionized water, polyvinyl alcohol, cetyltrimethylammonium bromide, α-monoalkyl glycerol ether, glycerin according to the prescription amount at room temperature, and add benzalkonium chloride , Benzalkonium chloride, stir evenly, and pack it separately.

Example 5

Benzalkonium Bromide 50kg Menthoxylin Ether 20kg Carbomer 10kg

Polyethylene glycol-400 100kg Polyethylene glycol-3350 100kg Sodium carboxymethyl cellulose 20kg

Polyoxyethylene polyoxypropylene copolyether 60kg Polyglycerol-polybutylene fatty alcohol ether 50kg

Butyl stearate 30kg Distilled water 560kg

Preparation method: Distilled water, carbomer, sodium carboxymethyl cellulose, polyoxyethylene polyoxypropylene copolyether, polyglycerol-polybutylene fatty alcohol ether, butyl stearate, polyethylene glycol Glycol-400 and Polyethylene Glycol-3350 are mixed and stirred evenly, add benzalkonium bromide and menthenyl ether, stir evenly, and pack them separately.

Example 6

Triclosan 30kg Alkylphenol ether 10kg Polyvinylpyrrolidone 30kg

Polyethylene glycol-400 400kg Polyvinyl alcohol 20kg Isopropyl isostearate 30kg

Sodium Lauryl Dimethyl Acetate 50kg Glycerol 45kg Deionized Water 385kg

Preparation method: deionized water, polyvinylpyrrolidone, polyvinyl alcohol, isopropyl isostearate, polyvinylpyrrolidone, sodium dodecyldimethylacetate, glycerol, polyvinyl Ethylene Glycol-400 is mixed and stirred evenly, add triclosan and alkanol ether, stir evenly, and pack it separately.

Example 7

Chlorhexidine acetate 30kg Phenyl alcohol ether 10kg Sodium carboxymethyl cellulose 30kg

Polyvinyl alcohol 50kg Alkyl amidopropyl betaine 20kg

Alkyl imidazoline 30kg propylene glycol 200kg deionized water 630kg

Preparation method: Mix and stir deionized water, sodium carboxymethylcellulose, polyvinyl alcohol, alkyl amidopropyl betaine, alkyl imidazoline, propylene glycol, and triethanolamine according to the prescription amount at room temperature, and add chlorohexyl acetate Ding and nonoxynol are stirred evenly, and then packed separately.

Example 8

Nano silver 0.1g octoxynol 20g

Carbomer 940 15g Triethanolamine 150g

Glycerol 200g Deionized water 550g

Preparation method: Dissolve nano-silver and octoxynol in 150kg of deionized water at room temperature; add carbomer 940 to glycerol and grind to make it wet and partially swell, the swelling degree of carbomer is 50%, add 350kg Distilled water to absorb water and swell fully until it becomes a translucent gel, then dissolve triethanolamine in 50kg deionized water and add the above gel, grind it into a thick and transparent gel matrix, add the above nano-silver, octoxynol Solution, grind well, then pack.

Claims (16)

1. A compound preparation for vaginal administration of sterilization, sterilization and spermicide and anti-pregnancy, characterized in that it comprises the following components by weight: Broad-spectrum antibacterial agent 0.01-50, anti-pregnancy spermicide 2-20. 2. According to the compound preparation according to claim 1, it is characterized in that comprising the following components by weight: Broad-spectrum antibacterial agent 15-50, anti-pregnancy spermicide 2-20. 3. The compound preparation according to claim 1, characterized in that it comprises the following components by weight: Broad-spectrum antibacterial agent 0.01-0.1, anti-pregnancy spermicide 2-20. 4. The compound preparation according to claim 1, 2 or 3, characterized in that said compound preparation further comprises the following components in parts by weight: water 90-750 and medically acceptable amount of auxiliary materials. 5. According to the compound preparation according to claim 4, it is characterized in that said broad-spectrum antibacterial agent is one or several of nano-silver, benzalkonium chloride, benzalkonium bromide, chlorhexidine acetate, and triclosan mixture. 6. The compound preparation according to claim 5, characterized in that the particle size of the nano-silver is 1-100 nanometers. 7. According to the compound preparation according to claim 1, 2 or 3, it is characterized in that said anti-pregnancy spermicide is octoxynol, nonoxynol ether, alkanol ether, menthoxynol ether, benzyl chloride One or a mixture of ammonium. 8. The compound preparation according to claim 4, characterized in that said adjuvant is one or a mixture of monomer carriers, surfactants and dispersants. 9. According to the compound preparation according to claim 8, it is characterized in that the weight ratio of said auxiliary materials: Monomer carrier 15-815 Surfactant 50-140 Dispersant 45-350. 10, according to the compound preparation of claim 9, it is characterized in that described monomer carrier is carbomer, sodium carboxymethylcellulose (CMC-Na), polyvinylpyrrolidone (PVP), polyvinyl alcohol (PVA), One or a mixture of polyethylene glycol-400 and polyethylene glycol-3350. 11. According to the compound preparation according to claim 9, it is characterized in that said surfactant is sodium lauryl sulfate, stearic acid, stearyl alcohol, sodium lauryl sulfate (AS), sodium lauryl sulfate (SDS), cetyltrimethylammonium bromide (CTAB), α-monoalkyl glyceryl ether (GE), polyoxyethylene polyoxypropylene copolyether, polyglycerol-polybutylene fatty alcohol ether (PGT alkane base ether), fructoside, butyl stearate, isopropanol isostearate, polyvinylpyrrolidone, sodium lauryl dimethyl acetate (BS-12), alkyl amidopropyl betaine, alkanes One or a mixture of several imidazolines. 12. The compound preparation according to claim 9, characterized in that the dispersant is one of glycerol, propylene glycol, sodium lauryl sulfate, triethanolamine or a mixture of several of them. 13. The compound preparation according to claim 4 is a gel. 14. A method for preparing a sterilizing and spermicidal anti-pregnancy compound preparation for vaginal administration, comprising: mixing and stirring water, monomer carriers, surfactants, and dispersants evenly at room temperature, adding broad-spectrum antibacterial agents, antibacterial agents, and antibacterial agents. Stir the pregnant spermicide evenly and pack it separately. 15. A method for preparing a sterilizing and spermicidal anti-pregnancy compound preparation for vaginal administration, comprising: mixing and stirring water, monomer carriers, surfactants, and dispersants evenly at room temperature, adding broad-spectrum antibacterial agents, antibacterial agents, and antibacterial agents. Stir the pregnant spermicide evenly, add stearic acid and/or stearyl alcohol under the condition of heating and stirring at 60-90°C, mix evenly, cool to solidify under stirring, and pack separately. 16. A method for preparing a sterilizing and spermicidal anti-pregnancy compound preparation for vaginal administration, comprising: dissolving broad-spectrum antibacterial agents and anti-pregnancy spermicides in water at room temperature; adding carbomer to glycerol Grind to make it wet and partially swell, the swelling degree of carbomer is 40-60%, add water to make it fully swell until it absorbs water until it becomes a translucent gel, then dissolve the dispersant in water and add the above gel, grind until it becomes thick Thick and transparent gel matrix, add the above-mentioned broad-spectrum antibacterial agent, anti-pregnancy spermicide solution, grind well, and then pack it.