CN1609090A - Technological process of extracting nervonic acid from Acertruncatum Bunge oil - Google Patents
Technological process of extracting nervonic acid from Acertruncatum Bunge oil Download PDFInfo
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- CN1609090A CN1609090A CN 200310105852 CN200310105852A CN1609090A CN 1609090 A CN1609090 A CN 1609090A CN 200310105852 CN200310105852 CN 200310105852 CN 200310105852 A CN200310105852 A CN 200310105852A CN 1609090 A CN1609090 A CN 1609090A
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- selacholeic acid
- acid
- selacholeic
- nervonic acid
- chloroform
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- GWHCXVQVJPWHRF-KTKRTIGZSA-N (15Z)-tetracosenoic acid Chemical compound CCCCCCCC\C=C/CCCCCCCCCCCCCC(O)=O GWHCXVQVJPWHRF-KTKRTIGZSA-N 0.000 title claims abstract description 66
- 241000219226 Acer truncatum Species 0.000 title claims description 24
- 238000000034 method Methods 0.000 title abstract description 4
- XJXROGWVRIJYMO-SJDLZYGOSA-N Nervonic acid Natural products O=C(O)[C@@H](/C=C/CCCCCCCC)CCCCCCCCCCCC XJXROGWVRIJYMO-SJDLZYGOSA-N 0.000 title abstract 7
- GWHCXVQVJPWHRF-UHFFFAOYSA-N cis-tetracosenoic acid Natural products CCCCCCCCC=CCCCCCCCCCCCCCC(O)=O GWHCXVQVJPWHRF-UHFFFAOYSA-N 0.000 title abstract 7
- 238000000605 extraction Methods 0.000 claims abstract description 11
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical group OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 45
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 claims description 33
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 27
- 229960001701 chloroform Drugs 0.000 claims description 18
- 239000000047 product Substances 0.000 claims description 15
- 239000000284 extract Substances 0.000 claims description 10
- 239000000243 solution Substances 0.000 claims description 10
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 9
- 238000004458 analytical method Methods 0.000 claims description 9
- 238000002425 crystallisation Methods 0.000 claims description 9
- 230000008025 crystallization Effects 0.000 claims description 9
- 238000007127 saponification reaction Methods 0.000 claims description 9
- 239000000741 silica gel Substances 0.000 claims description 9
- 229910002027 silica gel Inorganic materials 0.000 claims description 9
- 229960001866 silicon dioxide Drugs 0.000 claims description 9
- 239000000203 mixture Substances 0.000 claims description 7
- 238000003672 processing method Methods 0.000 claims description 7
- 235000011114 ammonium hydroxide Nutrition 0.000 claims description 6
- 230000006837 decompression Effects 0.000 claims description 6
- 239000003480 eluent Substances 0.000 claims description 6
- 239000012530 fluid Substances 0.000 claims description 6
- 238000004519 manufacturing process Methods 0.000 claims description 6
- 238000002156 mixing Methods 0.000 claims description 6
- 239000000344 soap Substances 0.000 claims description 6
- 239000002594 sorbent Substances 0.000 claims description 6
- 238000004809 thin layer chromatography Methods 0.000 claims description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 6
- 238000012360 testing method Methods 0.000 claims description 5
- 238000001514 detection method Methods 0.000 claims description 4
- 238000005516 engineering process Methods 0.000 claims description 4
- 238000004817 gas chromatography Methods 0.000 claims description 4
- 238000004128 high performance liquid chromatography Methods 0.000 claims description 4
- 239000007791 liquid phase Substances 0.000 claims description 4
- 238000012544 monitoring process Methods 0.000 claims description 4
- 239000003795 chemical substances by application Substances 0.000 claims description 3
- 239000012043 crude product Substances 0.000 claims description 3
- 238000004821 distillation Methods 0.000 claims description 3
- 238000010828 elution Methods 0.000 claims description 3
- 239000007788 liquid Substances 0.000 claims description 3
- 239000011259 mixed solution Substances 0.000 claims description 3
- 239000000843 powder Substances 0.000 claims description 3
- 238000011084 recovery Methods 0.000 claims description 3
- 238000007670 refining Methods 0.000 claims description 3
- 239000002904 solvent Substances 0.000 claims description 3
- 238000005303 weighing Methods 0.000 claims description 3
- 238000012545 processing Methods 0.000 claims description 2
- 241000251730 Chondrichthyes Species 0.000 abstract description 8
- 210000001519 tissue Anatomy 0.000 abstract description 4
- 241000196324 Embryophyta Species 0.000 abstract description 2
- 230000002490 cerebral effect Effects 0.000 abstract description 2
- 239000000463 material Substances 0.000 abstract description 2
- 210000001525 retina Anatomy 0.000 abstract description 2
- 235000021122 unsaturated fatty acids Nutrition 0.000 abstract description 2
- 150000004670 unsaturated fatty acids Chemical class 0.000 abstract description 2
- 241000612118 Samolus valerandi Species 0.000 abstract 2
- 241000124008 Mammalia Species 0.000 abstract 1
- 238000009776 industrial production Methods 0.000 abstract 1
- 210000000944 nerve tissue Anatomy 0.000 abstract 1
- 230000002459 sustained effect Effects 0.000 abstract 1
- 239000003921 oil Substances 0.000 description 21
- 235000019198 oils Nutrition 0.000 description 21
- 210000004556 brain Anatomy 0.000 description 5
- 239000002253 acid Substances 0.000 description 3
- 210000004958 brain cell Anatomy 0.000 description 3
- 210000003792 cranial nerve Anatomy 0.000 description 3
- 239000002994 raw material Substances 0.000 description 3
- 208000024827 Alzheimer disease Diseases 0.000 description 2
- 206010039966 Senile dementia Diseases 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 230000004641 brain development Effects 0.000 description 2
- 239000008157 edible vegetable oil Substances 0.000 description 2
- 150000004668 long chain fatty acids Chemical class 0.000 description 2
- 208000024172 Cardiovascular disease Diseases 0.000 description 1
- 208000016192 Demyelinating disease Diseases 0.000 description 1
- 206010012305 Demyelination Diseases 0.000 description 1
- 210000000593 adipose tissue white Anatomy 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 230000036995 brain health Effects 0.000 description 1
- 210000000170 cell membrane Anatomy 0.000 description 1
- 208000026106 cerebrovascular disease Diseases 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000002526 effect on cardiovascular system Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000004438 eyesight Effects 0.000 description 1
- 230000001605 fetal effect Effects 0.000 description 1
- 210000003754 fetus Anatomy 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 229930182478 glucoside Natural products 0.000 description 1
- 150000008131 glucosides Chemical class 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 230000007830 nerve conduction Effects 0.000 description 1
- 150000003904 phospholipids Chemical class 0.000 description 1
- 230000035935 pregnancy Effects 0.000 description 1
- 210000000582 semen Anatomy 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
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- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
The present invention relates to the extraction of medicinal plant component, and is especially technological process of extracting nervonic acid from Acertrunatum Bunge oil. Nervonic acid is one kind of long chain unsaturated fatty acid and up to now, it is extracted from deep sea shark and shark oil. Nervonic acid is found existing in nerve tissue and cerebral tissue of mammal as well as in retina and sperm, and is important component of biomembrane. Acertrunatum Bunge oil has nervonic acid content up to 5.5 %, so that it may be sued as sustained nervonic acid source. The present invention is the nervonic acid extracting method with wide material source and low extracting cost, and suitable for industrial production.
Description
One, technical field:
The present invention relates to medicinal plant composition extraction process, is a kind of processing method of extracting Selacholeic acid with Acertruncatum Bunge oil specifically.
Two, technical background:
Selacholeic acid (Nervoic Acid) is a kind of long-chain unsaturated fatty acid, because it is mainly derived from deep-sea shark and shark oil shai, also claims shark acid.Chemistry is by name along the 15-tetracosenoic acid, and molecular formula is C
24H
46O
2, molecular weight is 366.6, white powdery solid.
Selacholeic acid is found in mammiferous nervous tissue the earliest, content is higher in nervous tissue and cerebral tissue, also is present among retina and the seminal fluid, is biomembranous important component part, usually the formation with sphingoglycolipid and sphingophospholipid is present in the white fat of brain, is the mark of medullary substance in the brain glucoside.
1, Selacholeic acid has great effect to brain development:
Discovering of the brain nutritionist croft of Britain, the baby is 400 grams from the weight of when birth brain, 1400 grams when being increased to the adult, and what increased is the network that connects neurocyte, and these networks mainly are to be made of lipid, and wherein Selacholeic acid content can reach 10%.That is to say that Selacholeic acid is to the important role of having grown of cranial nerve conduction and cynapse.Gestation fetus beginning in 3rd month brain development if parent lacks Selacholeic acid, can cause the phospholipid deficiency of fetal brain cell, thereby influence the g and D of its brain cell, produces the retarded child.
2, have good result to curing senile dementia and being losing one's memory:
Selacholeic acid is difficult to synthesize at human body self, but the essential material of body.Enter the old stage, big cephalopin changes, and especially Selacholeic acid content descends obviously, is accompanied by hypomnesis to occur, even causes senile dementia to occur.Selacholeic acid prevents that to improving the active of cranial nerve the cranial nerve aging from having great role, and by the adjusting of Selacholeic acid cell membrane function, the continuous formation of the information that can strengthen between brain cell, thereby hypermnesis improve brain health level.
3, can be used for treating demyelination, health immunity tetter and cardiovascular and cerebrovascular disease help to improve eyesight.
4, Selacholeic acid suitability for industrialized production not as yet so far:
Chemosynthesis Selacholeic acid route, complex process, yield be low, can't realize industrialization.From shark oil shai and brain, extract, be subjected to resource restriction, also can't produce in batches.
Three, summary of the invention:
The object of the present invention is to provide the processing method that a kind of Selacholeic acid raw material sources are extensive, extraction cost is low with Acertruncatum Bunge oil extraction Selacholeic acid.
For achieving the above object, the technical solution used in the present invention is:
With the processing method of Acertruncatum Bunge oil extraction Selacholeic acid, its special character is: described processing step is as follows:
(1), with the refining Acertruncatum Bunge oil of overcritical multi-element fluid precise distillation technology, obtain Selacholeic acid glyceryl ester; Take by weighing a certain amount of Acer Truncatum Buge kernel, irritate with the accurate multithread of overcritical multi-element fluid, extract Acertruncatum Bunge oil, used entrainment agent is a methyl alcohol, and consumption is 10 times of sample.
(2), Selacholeic acid glyceride saponification; With sodium hydroxide ethanolic soln mixing solutions saponification Selacholeic acid glyceride, obtain the soap mixture, used sodium hydroxide and ethanolic soln ratio are 1: 1.5, PH detects greater than 9.
(3), detect, use the 1.0773.0500 sorbent material, silicagel column carries out obligate to Selacholeic acid and adsorbs through thin-layer chromatography; The soap mixture is added the silicagel column that disposes the 1.0773.0500 sorbent material, Selacholeic acid is adsorbed.
(4), through special-purpose eluent wash-out, obtain the Selacholeic acid mixed product; Eluent is the saponification of sodium hydroxide ethanolic soln mixing solutions, methyl alcohol, ammoniacal liquor, pure water, and its ratio is 70: 25: 3: 2; Be adsorbed on Selacholeic acid trichloromethane, methyl alcohol, ammoniacal liquor, the pure water mixed solution gradient elution of silicagel column, TLC detects, and merges Selacholeic acid, and decompressing and extracting gets lacteous powder sample Selacholeic acid.
(5), alkaline chloroform extraction, through crystallization, obtain the Selacholeic acid crystallization of 90% above purity; Alkalescence chloroform PH＞10.With the Selacholeic acid crude product that (4) step obtained, use earlier the analytical pure dissolve with methanol, filter, residue is abandoned or adopted, and with alkaline chloroform decompression extracting, combined chloroform liquid reclaims the chloroform crystallization at last and gets the Selacholeic acid elaboration again for methanol solution decompression and solvent recovery, gained medicinal extract.
(6), in entire production process, utilize gas-chromatography GC and height liquid phase HPLC instrumental analysis means of testing, the product of each link is carried out to is grouped into and the content detection analysis, carry out the dynamic monitoring of quality product, and omnidistance Selacholeic acid quality product trackability and the controllability of guaranteeing.
The present invention is with respect to prior art, and its advantage is as follows:
The present invention adopts Acertruncatum Bunge oil as raw material, and Selacholeic acid content reaches 5.5% in the Acertruncatum Bunge oil, thereby it is extensive, cheap to extract raw material sources.
The present invention adopts Acertruncatum Bunge oil to detect by analysis in its long chain fatty acid, finds that it contains higher Selacholeic acid, is rare in edible vegetable oil, compares with deep-sea shark oil shai, and Acertruncatum Bunge oil is the Selacholeic acid new resources of sustainable use.
Extraction process of the present invention is simple to operate, extraction yield is high, be applicable to suitability for industrialized production.
Of the present invention in entire production process, utilize gas-chromatography GC and height liquid phase HPLC instrumental analysis means of testing, the product of each link is carried out to is grouped into and the content detection analysis, carry out the dynamic monitoring of quality product, and omnidistance Selacholeic acid quality product trackability and the controllability of guaranteeing.
Four, description of drawings:
Fig. 1 extracts the schema of the processing method of Selacholeic acid for the present invention;
Five, embodiment:
Selacholeic acid content reaches 5.5% in the Acertruncatum Bunge oil.The scientific and technical personnel of Yangling Yuanbao Maple Biological Product Co., Ltd. carry out long term studies to Acertruncatum Bunge oil, in its long chain fatty acid of analyzing and testing, find that it contains higher Selacholeic acid, be rare in edible vegetable oil, compare with deep-sea shark oil shai, Acertruncatum Bunge oil is the Selacholeic acid new resources of sustainable use.Thereby found the new way in Selacholeic acid source, and improved the technology and the parameter thereof of Acertruncatum Bunge oil extraction Selacholeic acid.
Referring to Fig. 1, it is of the present invention that to extract the processing method step of Selacholeic acid with Acertruncatum Bunge oil as follows:
(1), with the refining Acertruncatum Bunge oil of overcritical multi-element fluid precise distillation technology, obtain Selacholeic acid glyceryl ester; Take by weighing a certain amount of Acer Truncatum Buge kernel, irritate with the accurate multithread of overcritical multi-element fluid, extract Acertruncatum Bunge oil, used entrainment agent is a methyl alcohol, and consumption is 10 times of sample.
(2), Selacholeic acid glyceride saponification; With sodium hydroxide ethanolic soln mixing solutions saponification Selacholeic acid glyceride, obtain the soap mixture, used sodium hydroxide and ethanolic soln ratio are 1: 1.5, PH detects greater than 9.
(3), detect, use the 1.0773.0500 sorbent material, silicagel column carries out obligate to Selacholeic acid and adsorbs through thin-layer chromatography; The soap mixture is added the silicagel column that disposes the 1.0773.0500 sorbent material, Selacholeic acid is adsorbed.
(4), through special-purpose eluent wash-out, obtain the Selacholeic acid mixed product; Eluent is the saponification of sodium hydroxide ethanolic soln mixing solutions, methyl alcohol, ammoniacal liquor, pure water, and its ratio is 70: 25: 3: 2; Be adsorbed on Selacholeic acid trichloromethane, methyl alcohol, ammoniacal liquor, the pure water mixed solution gradient elution of silicagel column, TLC detects, and merges Selacholeic acid, and decompressing and extracting gets lacteous powder sample Selacholeic acid.
(5), alkaline chloroform extraction, through crystallization, obtain the Selacholeic acid crystallization of 90% above purity; Alkalescence chloroform PH＞10.With the Selacholeic acid crude product that (4) step obtained, use earlier the analytical pure dissolve with methanol, filter, residue is abandoned or adopted, and with alkaline chloroform decompression extracting, combined chloroform liquid reclaims the chloroform crystallization at last and gets the Selacholeic acid elaboration again for methanol solution decompression and solvent recovery, gained medicinal extract.
(6), in entire production process, utilize gas-chromatography GC and height liquid phase HPLC instrumental analysis means of testing, the product of each link is carried out to is grouped into and the content detection analysis, carry out the dynamic monitoring of quality product, and omnidistance Selacholeic acid quality product trackability and the controllability of guaranteeing.
Claims (1)
1, extract the processing method of Selacholeic acid with Acertruncatum Bunge oil, it is characterized in that: described processing step is as follows:
(1), with the refining Acertruncatum Bunge oil of overcritical multi-element fluid precise distillation technology, obtain Selacholeic acid glyceryl ester; Take by weighing a certain amount of Acer Truncatum Buge kernel, irritate with the accurate multithread of overcritical multi-element fluid, extract Acertruncatum Bunge oil, used entrainment agent is a methyl alcohol, and consumption is 10 times of sample.
(2), Selacholeic acid glyceride saponification; With sodium hydroxide ethanolic soln mixing solutions saponification Selacholeic acid glyceride, obtain the soap mixture, used sodium hydroxide and ethanolic soln ratio are 1: 1.5, PH detects greater than 9.
(3), detect, use the 1.0773.0500 sorbent material, silicagel column carries out obligate to Selacholeic acid and adsorbs through thin-layer chromatography; The soap mixture is added the silicagel column that disposes the 1.0773.0500 sorbent material, Selacholeic acid is adsorbed.
(4), through special-purpose eluent wash-out, obtain the Selacholeic acid mixed product; Eluent is the saponification of sodium hydroxide ethanolic soln mixing solutions, methyl alcohol, ammoniacal liquor, pure water, and its ratio is 70: 25: 3: 2; Be adsorbed on Selacholeic acid trichloromethane, methyl alcohol, ammoniacal liquor, the pure water mixed solution gradient elution of silicagel column, TLC detects, and merges Selacholeic acid, and decompressing and extracting gets lacteous powder sample Selacholeic acid.
(5), alkaline chloroform extraction, through crystallization, obtain the Selacholeic acid crystallization of 90% above purity; Alkalescence chloroform PH＞10.With the Selacholeic acid crude product that (4) step obtained, use earlier the analytical pure dissolve with methanol, filter, residue is abandoned or adopted, and with alkaline chloroform decompression extracting, combined chloroform liquid reclaims the chloroform crystallization at last and gets the Selacholeic acid elaboration again for methanol solution decompression and solvent recovery, gained medicinal extract.
(6), in entire production process, utilize gas-chromatography GC and height liquid phase HPLC instrumental analysis means of testing, the product of each link is carried out to is grouped into and the content detection analysis, carry out the dynamic monitoring of quality product, and omnidistance Selacholeic acid quality product trackability and the controllability of guaranteeing.
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|---|---|---|---|
| CN 200310105852 CN1609090A (en) | 2003-10-23 | 2003-10-23 | Technological process of extracting nervonic acid from Acertruncatum Bunge oil |
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|---|---|---|---|
| CN 200310105852 CN1609090A (en) | 2003-10-23 | 2003-10-23 | Technological process of extracting nervonic acid from Acertruncatum Bunge oil |
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| CN1609090A true CN1609090A (en) | 2005-04-27 |
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Cited By (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1311751C (en) * | 2005-07-14 | 2007-04-25 | 马新世 | Nutrient milk with rich neurotic acids and acer truncatum oil and its preparation |
| CN100341839C (en) * | 2005-11-22 | 2007-10-10 | 陕西宝枫科技股份有限公司 | Method for extracting nervonic acid from acer truncatum buge oil |
| CN101092344B (en) * | 2007-07-06 | 2011-01-19 | 杨凌七彩生物科技有限公司 | Method for extracting nervonic acid from oil of Mono Maple by using technique of molecular distillation |
| CN101486647B (en) * | 2009-02-11 | 2012-05-30 | 中国科学院山西煤炭化学研究所 | A method for purifying neurate from a mixture of neurate and erucate |
| CN102614232A (en) * | 2012-04-23 | 2012-08-01 | 昆明海之灵生物科技开发有限公司 | Acer truncatum health-care lozenge and preparation method thereof |
| CN101283797B (en) * | 2008-05-08 | 2012-11-07 | 昆明云大医药开发有限公司 | Health products for promoting the intelligence and strengthening the brain using walnut oil as matrix |
| CN101575282B (en) * | 2009-06-15 | 2012-11-14 | 中国科学院山西煤炭化学研究所 | Method for using molecular distillation to extract nervonic acid from acer truncatum buge oil |
| CN103826714A (en) * | 2011-07-06 | 2014-05-28 | 巴斯夫制药（卡兰尼什）公司 | SMB process for producing highly pure EPA from fish oil |
| CN105503580A (en) * | 2015-12-09 | 2016-04-20 | 江西青春康源制药有限公司 | Method for extracting and separating nervonic acid |
| CN107353199A (en) * | 2017-08-10 | 2017-11-17 | 王显权 | The method of Malania Oleifera Oil separating-purifying nervonic acid |
| CN107462644A (en) * | 2017-07-26 | 2017-12-12 | 北京元宝枫世纪农业科技有限公司 | A kind of method that identification nervonic acid is combined by ultra performance liquid chromatography flight time mass spectrum and determines its concentration |
| CN108802246A (en) * | 2018-06-08 | 2018-11-13 | 禾大西普化学（四川）有限公司 | A kind of nervonic acid process for separation and purification |
| CN108863764A (en) * | 2018-07-20 | 2018-11-23 | 李明龙 | A kind of improvement memory improves the nervonic acid piece preparation method of sleep quality |
| CN111072469A (en) * | 2019-12-16 | 2020-04-28 | 西安尚诚生物科技有限公司 | Method for extracting natural nervonic acid |
| CN111735888A (en) * | 2020-08-14 | 2020-10-02 | 宝枫生物科技（北京）有限公司 | Biomarker for diagnosing onset of nervonic acid in acer truncatum seed oil and application of biomarker |
| CN112299986A (en) * | 2020-11-25 | 2021-02-02 | 宝鸡文理学院 | A kind of separation and purification process of nervonic acid in Yuanbao maple seed oil |
| CN112618588A (en) * | 2020-12-15 | 2021-04-09 | 山东永春堂集团有限公司 | Acer truncatum oil emulsion and application thereof |
| CN112939761A (en) * | 2021-03-05 | 2021-06-11 | 贵州精萃生物科技有限公司 | Method for extracting nervonic acid |
| CN114853593A (en) * | 2022-05-12 | 2022-08-05 | 北京化工大学 | A method for extracting high-purity nervonic acid from Yuanbao maple oil |
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2003
- 2003-10-23 CN CN 200310105852 patent/CN1609090A/en active Pending
Cited By (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1311751C (en) * | 2005-07-14 | 2007-04-25 | 马新世 | Nutrient milk with rich neurotic acids and acer truncatum oil and its preparation |
| CN100341839C (en) * | 2005-11-22 | 2007-10-10 | 陕西宝枫科技股份有限公司 | Method for extracting nervonic acid from acer truncatum buge oil |
| CN101092344B (en) * | 2007-07-06 | 2011-01-19 | 杨凌七彩生物科技有限公司 | Method for extracting nervonic acid from oil of Mono Maple by using technique of molecular distillation |
| CN101283797B (en) * | 2008-05-08 | 2012-11-07 | 昆明云大医药开发有限公司 | Health products for promoting the intelligence and strengthening the brain using walnut oil as matrix |
| CN101486647B (en) * | 2009-02-11 | 2012-05-30 | 中国科学院山西煤炭化学研究所 | A method for purifying neurate from a mixture of neurate and erucate |
| CN101575282B (en) * | 2009-06-15 | 2012-11-14 | 中国科学院山西煤炭化学研究所 | Method for using molecular distillation to extract nervonic acid from acer truncatum buge oil |
| CN103826714A (en) * | 2011-07-06 | 2014-05-28 | 巴斯夫制药（卡兰尼什）公司 | SMB process for producing highly pure EPA from fish oil |
| CN103826714B (en) * | 2011-07-06 | 2016-03-09 | 巴斯夫制药（卡兰尼什）公司 | For the SMB method of production high-purity EPA from fish oil |
| CN102614232A (en) * | 2012-04-23 | 2012-08-01 | 昆明海之灵生物科技开发有限公司 | Acer truncatum health-care lozenge and preparation method thereof |
| CN105503580A (en) * | 2015-12-09 | 2016-04-20 | 江西青春康源制药有限公司 | Method for extracting and separating nervonic acid |
| CN107462644A (en) * | 2017-07-26 | 2017-12-12 | 北京元宝枫世纪农业科技有限公司 | A kind of method that identification nervonic acid is combined by ultra performance liquid chromatography flight time mass spectrum and determines its concentration |
| CN107353199A (en) * | 2017-08-10 | 2017-11-17 | 王显权 | The method of Malania Oleifera Oil separating-purifying nervonic acid |
| CN108802246A (en) * | 2018-06-08 | 2018-11-13 | 禾大西普化学（四川）有限公司 | A kind of nervonic acid process for separation and purification |
| CN108802246B (en) * | 2018-06-08 | 2021-04-23 | 禾大西普化学（四川）有限公司 | Nervonic acid separating and purifying method |
| CN108863764A (en) * | 2018-07-20 | 2018-11-23 | 李明龙 | A kind of improvement memory improves the nervonic acid piece preparation method of sleep quality |
| CN111072469A (en) * | 2019-12-16 | 2020-04-28 | 西安尚诚生物科技有限公司 | Method for extracting natural nervonic acid |
| CN111072469B (en) * | 2019-12-16 | 2022-12-09 | 西安尚诚生物科技有限公司 | Method for extracting natural nervonic acid |
| CN111735888A (en) * | 2020-08-14 | 2020-10-02 | 宝枫生物科技（北京）有限公司 | Biomarker for diagnosing onset of nervonic acid in acer truncatum seed oil and application of biomarker |
| CN111735888B (en) * | 2020-08-14 | 2020-11-20 | 宝枫生物科技（北京）有限公司 | Biomarker for diagnosing onset of nervonic acid in acer truncatum seed oil and application of biomarker |
| CN112299986A (en) * | 2020-11-25 | 2021-02-02 | 宝鸡文理学院 | A kind of separation and purification process of nervonic acid in Yuanbao maple seed oil |
| CN112618588A (en) * | 2020-12-15 | 2021-04-09 | 山东永春堂集团有限公司 | Acer truncatum oil emulsion and application thereof |
| CN112939761A (en) * | 2021-03-05 | 2021-06-11 | 贵州精萃生物科技有限公司 | Method for extracting nervonic acid |
| CN112939761B (en) * | 2021-03-05 | 2023-10-20 | 贵州精萃生物科技有限公司 | Method for extracting nervonic acid |
| CN114853593A (en) * | 2022-05-12 | 2022-08-05 | 北京化工大学 | A method for extracting high-purity nervonic acid from Yuanbao maple oil |
| CN114853593B (en) * | 2022-05-12 | 2023-08-29 | 北京化工大学 | A method for extracting high-purity nervous acid from Yuanbao maple oil |
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