CN1682828A - Yinhuang Qingfei capsule and preparation method thereof - Google Patents

Abstract

The present invention discloses a kind of lung clearing Yinhuang capsule prepared with gingko leaf, roasted ephedra, northern pepperweed seed, almond, thunberg fritillary bulb and other nine kinds of Chinese medicinal materials. The lung clearing Yinhuang capsule is used in the treatment of retention of phlegm-heat in the lung caused acute attack of chronic bronchitis, and has the advantages of taking convenience and high treating effect.

Description

Yinhuang Qingfei capsule and preparation method thereof

technical field

The invention relates to a traditional Chinese medicine preparation and a preparation method thereof, in particular to a capsule with the functions of clearing the lung, resolving phlegm, relieving cough and relieving asthma, and is used for the treatment of chronic bronchitis.

Background technique

Bronchitis is a common disease, which can be caused by influenza. It belongs to the category of cough in traditional Chinese medicine. It is easy to relapse and has a long course. It often occurs in cold seasons. If it is not cured for a long time, it can continue to progress and cause emphysema, pulmonary heart disease, respiratory failure, and even life-threatening. Acute attack of chronic bronchitis with phlegm-heat obstructing the lungs is a clinical type of bronchitis. It brings great pain to the patient during the attack. At present, the traditional Chinese medicine preparations for the treatment of this disease are mostly syrups and oral liquids, all of which must be flavored with sweeteners. If the dosage of the flavoring agent is small, the taste will be difficult to use, and if the amount of the flavoring agent is too large, the efficacy will be reduced.

Contents of the invention

The object of the present invention is to provide a Yinhuang Qingfei Capsule for the treatment of acute exacerbation of chronic bronchitis with phlegm-heat obstructing the lung syndrome. The capsule is convenient to take and has good curative effect.

A Yinhuang Qingfei capsule is a capsule made of the following raw materials in parts by weight:

55-65 parts of Tinglizi, 35-40 parts of ephedra (steamed), 40-50 parts of bitter almond, 40-50 parts of Fritillaria, 40-50 parts of loquat leaves, 27-32 parts of Daqing leaves, Shichangpu 40-50 parts, 40-50 parts of Chuanshanlong, 27-32 parts of Artemisia argyi, 40-50 parts of Ginkgo biloba, 12-18 parts of Schisandra chinensis, 12-18 parts of Citrus aurantium, 55-65 parts of raw gypsum, 12-18 parts of licorice.

The preferred formulation is a capsule made from the following raw materials in parts by weight:

60 parts of Tinglizi, 37.5 parts of ephedra (burned), 45 parts of bitter almond, 45 parts of Fritillaria, 45 parts of loquat leaves, 30 parts of Daqingye, 45 parts of Shichangpu, 45 parts of pangosaurus, 30 parts of Artemisia argyi, 45 parts of Ginkgo biloba, 15 parts of Schisandra chinensis, 15 parts of Citrus aurantium, 60 parts of raw gypsum, 15 parts of licorice.

The present invention also provides the preparation method of above-mentioned Yinhuang Qingfei Capsules, the process is:

(1) Weigh each flavor of traditional Chinese medicine according to the formula;

(2) Crush the ephedra into fine powder and set aside;

(3) Dipping and extracting Tinglizi, Bitter Almond, Fritillaria Fructus, Fructus Aurantii, and Schisandra with ethanol at room temperature, recovering the ethanol in the extract, and concentrating it into an extract;

(4) decocting the medicinal residues after alcohol leaching in step (3) together with the remaining eight herbs, and concentrating the decocted medicinal liquid into an extract;

(5) drying the medicinal extract obtained in the above step (3) and step (4) into a dry medicinal extract, and then pulverizing into a fine powder;

(6) Mix the ephedra fine powder prepared in step (2) with the fine powder in step (5), add an appropriate amount of starch, granulate, and pack into capsules.

In the preparation method of the above-mentioned Yinhuang Qingfei Capsules, in step (3), Tinglizi, Bitter Almond, Fritillaria Fructus, Aurantium Fructus, and Schisandra are soaked and extracted with ethanol, and the following method can be used to make the medicinal ingredients of raw materials Extraction is more complete: Soak Tinglizi, bitter almond, Fritillaria chinensis, Citrus aurantium, Schisandra chinensis and five times the amount of ethanol, soaking for three times, each time for 24 hours, after filtering, combine the extracts of three soakings.

Described ethanol is most ideal with the ethanol that concentration is 70%.

The method for decocting the above-mentioned step (4) of the Chinese medicine dregs and the remaining eight-flavored medicines is as follows: decocting the dregs after ethanol soaking with the rest of the eight-flavored medicines together with 10 times the amount of water, each time for 1 hour, and then merging Decoction.

Each capsule of Yinhuang Qingfei is filled with 0.15g medicine, 3 capsules each time orally, three times a day, seven days as a course of treatment. Pregnant women should not take it. The ingredients of this product contain ephedrine, so it should be used with caution in patients with tachycardia and hypertension. Be careful in combination with cardiac glycosides.

The Yinhuang Qingfei Capsule of the present invention is a capsule, which is convenient to take, and besides the medicinal ingredients, only a small amount of starch is used as an excipient, so that the content of medicinal ingredients is high and the curative effect is good, and it can be used for chronic bronchitis For the treatment of acute attack of phlegm-heat obstructing the lung syndrome, it has the effects of clearing the lung and resolving phlegm, relieving cough and relieving asthma. Prescription: Fritillaria fritillaria, loquat leaves, calamus calamus for relieving cough and phlegm, ephedra for clearing lungs and relieving asthma, raw gypsum for clearing away lung-heat, Daqingye for clearing heat and detoxifying, Tinglizi, citrus aurantii, bitter almonds for lowering qi, pangosaurus Relieve cough and relieve asthma, Ginkgo biloba condenses the lungs and relieves asthma, Artemisia annua anti-inflammatory and detoxification, Schisandra chinensis nourishes qi, promotes body fluid, quenches thirst, licorice nourishes qi, nourishes lung deficiency, promotes body fluid and quenches thirst, and relieves the toxicity of Artemisia argyi. , the combination of Xuan and descending, clearing and eliminating synergy, its benefits are outstanding, to achieve the comprehensive therapeutic effect of clearing the lung and reducing phlegm, relieving cough and relieving asthma, clinical trials show that the Yinhuang Qingfei capsule of the present invention is symptomatic, and the comprehensive treatment effect is remarkable.

Detailed ways

The Yinhuang Qingfei Capsule of the present invention will be further described below in conjunction with specific examples.

Example 1

Yinhuang Qingfei Capsules are made of the following traditional Chinese medicine raw materials. Shichangpu 45g, Chuanshanlong 45g, Yizhi Artemisia 30g, Ginkgo biloba 45g, Schisandra 15g, Citrus aurantium 15g, raw gypsum 60g, licorice 15g.

The above fourteen traditional Chinese medicines are weighed according to the formula, the ephedra is crushed into fine powder, and set aside. Soak Tinglizi, Bitter Almond, Fritillaria, Fructus Aurantii, Schisandra plus five times the amount of 70% ethanol at room temperature for three times, each time for 24 hours, filter, combine the three extracts, recover the ethanol in the extract, and depressurize Concentrate into an extract with a relative density of 1.05 (50°C). Add 10 times the amount of water to decoct the dregs after alcohol immersion and the rest of the eight herbs such as loquat leaves, and decoct twice for 1 hour each time. paste. Combine the above two kinds of extracts, concentrate them to an extract with a relative density of about 1.2 (50°C), dry them in a vacuum to form a dry extract, and grind them into fine powder. granules, packed into 1000 capsules, each containing 0.15g, to get final product.

Example 2

In this example, Yinhuang Qingfei Capsules are composed of 65g of Tinglizi, 35g of ephedra (steamed), 48g of bitter almond, 40g of fritillaria, 50g of loquat leaves, 27g of Daqingye, 50g of Shichangpu, 40g of pangosaurus, and 32g of Artemisia chinensis. .

The above fourteen traditional Chinese medicines are weighed according to the formula, the ephedra is crushed into fine powder, and set aside. Soak Tinglizi, Bitter Almond, Fritillaria Fructus, Fructus Citrus Fructus Fructus Schisandra plus eight times the amount of 75% ethanol at room temperature twice, each time for 26 hours, filter, combine the second extracts, recover the ethanol in the extracts, Concentrate under reduced pressure to obtain an extract with a relative density of 1.05 (50°C). Add 10 times the amount of water to decoct the dregs after alcohol immersion and the rest of the eight herbs such as loquat leaves, and decoct twice for 1 hour each time. paste. Combine the above two kinds of extracts, then concentrate to extracts with a relative density of about 1.2 (50°C), then vacuum-dry them into dry extracts, grind them into fine powder, add the above-mentioned ephedra fine powder, add appropriate amount of starch, and granulate. Pack into 1000 capsules, each containing 0.15g.

Example 3

In this example, Yinhuang Qingfei Capsules are composed of 55g of Tinglizi, 40g of ephedra (steamed), 41g of bitter almond, 50g of Fritillaria japonicus, 40g of loquat leaf, 32g of Daqingye, 40g of Shichangpu, 50g of pangosaurus, and 27g of Artemisia chinensis. , Ginkgo biloba leaves 50g, schisandra 12g, citrus aurantium 18g, raw gypsum 55g, licorice 12g.

The above fourteen traditional Chinese medicines are weighed according to the formula, the ephedra is crushed into fine powder, and set aside. Soak Tinglizi, bitter almonds, Fritillaria chinensis, Citrus aurantium, and Schisandra plus six times the amount of 75% ethanol at room temperature for three times, each time for 24 hours, filter, combine the three extracts, recover the ethanol in the extract, and depressurize Concentrate into an extract with a relative density of 1.05 (50°C). The dregs after alcohol immersion and the remaining eight herbs such as loquat leaves are decocted three times with seven times the amount of water, each time for 1.2 hours, the decoctions are combined, and concentrated under reduced pressure to an extract with a relative density of about 1.1 (50°C) . Combine the above two kinds of extracts, then concentrate to extracts with a relative density of about 1.2 (50°C), then vacuum-dry them into dry extracts, grind them into fine powder, add the above-mentioned ephedra fine powder, add appropriate amount of starch, and granulate. Pack into 1000 capsules, each containing 0.15g.

Claims (6)

1, a kind of Yinhuang lung clearing capsule is characterized in that, is the capsule of being made by the raw material of following parts by weight:

55～65 parts of lepidii,semens, 35～40 parts in Herba Ephedrae (processing), 40～50 parts of Semen Armeniacae Amarums,

40～50 parts of Bulbus Fritillariae Thunbergiis, 40～50 parts of Folium Eriobotryaes, 27～32 parts of Folium Isatidiss,

40～50 parts of Rhizoma Acori Graminei, 40～50 parts of Rhizoma Dioscoreae Nipponicae, 27～32 parts of Herba Achilleaes,

40～50 parts of Folium Ginkgos, 12～18 parts of Fructus Schisandrae Chinensis, 12～18 parts of Fructus Aurantii Immaturuss,

55～65 parts of Gypsum Fibrosum, 12～18 parts in Radix Glycyrrhizae.

2, Yinhuang lung clearing capsule as claimed in claim 1 is characterized in that, is the capsule of being made by the raw material of following parts by weight:

60 parts of lepidii,semens, 37.5 parts in Herba Ephedrae (processing), 45 parts of Semen Armeniacae Amarums,

45 parts of Bulbus Fritillariae Thunbergiis, 45 parts of Folium Eriobotryaes, 30 parts of Folium Isatidiss,

45 parts of Rhizoma Acori Graminei, 45 parts of Rhizoma Dioscoreae Nipponicae, 30 parts of Herba Achilleaes,

45 parts of Folium Ginkgos, 15 parts of Fructus Schisandrae Chinensis, 15 parts of Fructus Aurantii Immaturuss,

60 parts of Gypsum Fibrosum, 15 parts in Radix Glycyrrhizae.

3, the preparation method of the described Yinhuang lung clearing capsule of a kind of claim 1 is characterized in that this method is:

(1) takes by weighing the Chinese medicine of respectively distinguishing the flavor of by prescription;

(2) Herba Ephedrae is ground into fine powder, standby;

(3) lepidii,semen, Semen Armeniacae Amarum, Bulbus Fritillariae Thunbergii, Fructus Aurantii Immaturus, Fructus Schisandrae Chinensis are extracted at the room temperature dipping with ethanol, reclaim ethanol in the extracting solution, be condensed into extractum;

(4) medicinal residues after the alcohol leaching in the step (3) are decocted with remaining eight flavor medicine water, the medicinal liquid that decocts is condensed into extractum;

(5) extract dry that makes in above-mentioned steps (3) and the step (4) is become dry extract, be ground into fine powder then;

(6) it is an amount of the Herba Ephedrae fine powder that makes in the step (2) and fine powder in the step (5) to be mixed and add starch, granulates, and incapsulates.

4, the preparation method of Yinhuang lung clearing capsule as claimed in claim 3, it is characterized in that, the method that lepidii,semen, Semen Armeniacae Amarum, Bulbus Fritillariae Thunbergii, Fructus Aurantii Immaturus, Fructus Schisandrae Chinensis extract with alcohol dipping in the above-mentioned steps (3) is: lepidii,semen, Semen Armeniacae Amarum, Bulbus Fritillariae Thunbergii, Fructus Aurantii Immaturus, Fructus Schisandrae Chinensis are added the quintuple alcohol dipping, flood altogether three times, each 24 hours, filter the extracting solution that the back merges three dippings.

5, as the preparation method of claim 3 or 4 described Yinhuang lung clearing capsules, it is characterized in that: described concentration of ethanol is 70%.

6, as the preparation method of claim 3 or 4 described Yinhuang lung clearing capsules, it is characterized in that, decocting methods of above-mentioned steps (4) Chinese medicine slag and remaining eight flavor medicines are: the medicinal residues after the alcohol dipping and remaining eight decocting that medicines one reinstate 10 times of amounts of distinguishing the flavor of are boiled secondary, each 1 hour, collecting decoction then.