CN1660207A - Preparation of health care for reducing blood fat and cholesterol, and producing method - Google Patents

Abstract

A Chinese medicine for preventing and treating atherosolerosis, hypercholesterinemia, hyperlipemia, hypertension, coronary heart disease, angina pectoris, etc is prepared from haw, lophatherum, cassia seed and alismatis rhizome.

Description

The health preparation of blood fat reducing and cholesterol and production method thereof

Technical field

The present invention relates to a kind of health product, particularly a kind of health preparation and production method thereof with blood fat reducing and cholesterol.

Background technology

At present along with living standard raising and aged tendency of population, the cardiovascular disease incidence rate is in rising trend, the serious threat human health, about the research of coronary heart disease and atherosclerosis aspect has become clinical and focus basic research, and coronary heart disease and atherosclerosis hyperlipemia are a kind of common cardiovascular disease, mainly cause owing to metabolism disorder of blood lipid, be divided into Primary hyperlipemia and Secondary cases hyperlipemia clinically, often show as hypercholesterolemia, hypertriglyceridemia or the two have concurrently.The generation development of itself and arteriosclerosis and cardiovascular disease has closely gets in touch, and becomes the risk factor of serious threat human health.Particularly the people when hyperlipemia takes place, can bring out a series of radical reactions in the body to person in middle and old age, the damage various types of cells.Bring out the aging of vitals such as liver, brain, the health that jeopardizes middle-aged and elderly people.Therefore, seek evident in efficacy, safe and reliable hypolipidemic is the problem that medical worker studies for a long period of time always.

A lot of medical science publications and medical expert point out, suitable diet, and good living habit is the principle of transferring the fat treatment with strengthening physical training, this also is the basis of Drug therapy.The patient higher for blood fat should use lipid lowerers, the medicine that the blood lipid-lowering medicine of the present clinical practice of doctor trained in Western medicine is used for the treatment of hyperlipemia has following a few class: cholesterol biosynthesis enzyme inhibitor, i.e. HMG-CoA reductase inhibitor, cholic acid integrated agent, nicotinic acid class medicine and fibrate, cholesterol absorption inhibitor.Blood lipid-lowering medicine that other is new such as cholesterol cheese acyltransferase inhibitor and cholesterol fracture activated protein part are also in research and development.1, the cholesterol biosynthesis enzyme inhibitor mainly is meant Statins, and this compounds mainly is to suppress the synthetic rate-limiting enzyme of cholesterol-work through first glutaryl CoA reductase (HMG-COA reductase) by selectivity.This enzyme is subjected to the metabolic adjusting of body inner cholesterol, if the emptying of cell inner cholesterol causes this enzymatic activity to increase, the body inner cholesterol is synthetic to quicken and make; On the contrary, cell inner cholesterol amount increases, and this enzymatic activity descends, synthetic slowing down in the cholesterol body.Statins makes the synthetic minimizing of endogenous cholesterol in the body by suppressing the HMG-CorA reductase, reduces the source of low-density lipoprotein cholesterol.Simultaneously, such medicine increase or activate surface of hepatocytes the ML expression of receptor level and reduce the content of ML in the blood.Therefore, it is good that statins has a selectivity, the characteristics that curative effect is high, and side effect is less, can obviously reduce the atherosclerosis and evidence of coronary heart diseases and the mortality rate that are caused by hypercholesterolemia.Be the main medicine of treatment hypercholesterolemia at present.Statins has multiple at present, as lovastatin simvastatin, pravastatin, atorvastatin, newer has: as fluvastatin, long-acting fluvastatin slow releasing tablet, cerivastatin, the modal untoward reaction of such medicine mainly is slight gastrointestinal reaction, headache, cerivastatin also with liver, untoward reaction that flesh is relevant, accidental transaminase raises, the caused musclar toxicity that has comprises myalgia, myositis, rhabdomyolysis.2. fibrate, this compounds belong to the special class of shellfish, are effectively medicines of triglyceride reducing level, and that uses clinically at present mainly contains ciprofibrate, bezafibrate, fenofibrate and gemfibrozil, and the ciprofibrate side effect is big, and clinical practice is few.If such drug main is by changing the gene of coding control lipoprotein metabolism, peroxide activator enzyme hypertrophy factor activated receptor transcription factor, reduce the generation of lipoprotein by the PPAR fibrate, cause the synthetic and secretion minimizing of liver very low density lipoprotein (VLDL), increase the enzymolysis activity of lipoprotein lipase, quicken the catabolism of triglyceride.3. the nicotinic acid class is the hypolipidemic of using the earliest, and its triglyceride reducing and cholesterol levels, but the quick releasing formulation erious adverse reaction of this medicine are not used separately basically, can reduce its gastrointestinal side effect effect with food with clothes.4. cholic acid integrated agent, this class medicine comprises the hydrochloric acid colesevelam of colestyramine, colestipol and up-to-date listing.By in intestinal with the cholic acid irreversible fixation, the resorption of cholic acid in intestinal received reduced the cholic acid increase of discharging from intestinal with feces, impel hepatocyte to increase the synthetic of cholic acid, its synthesis material cholesterol consumption increases, quicken the synthetic of receptor by the feedback mechanism cell cultured supernatant simultaneously, the content of T-CHOL in the blood is reduced.This class medicine is suitable for the hypercholesterolemia of any kind except that familial hypercholesterolemia, to the Hyperglycerolemia DeGrain of any kind.The treatment of the combined hyperlipidemia that triglyceride in the serum and cholesterol are all raise, must with the hypolipidemic coupling of other types.The absorption of bile cholesterol does not influence triglyceride and fat-soluble.5. cholesteryl ester inhibitors, 3 hydroxyls of cholesteryl ester acyltransferase (AOLT) catalysis cholesterol after by long-chain acyl coenzyme A the cheese acyl group being changed over to, generate cholesterol butyric acid enzyme, and it plays an important role in the metabolism of cholesterol.The novel blood lipid-lowering medicine of a class in the ACAT inhibitor conduct research and development now, by of the absorption of inhibition body to cholesterol, thus the T-CHOL in the reduction serum.(end considers whether the people CAT homology of human and rat has similar function) under study for action, the enzymoprivic rat of normal rat and ACAT gives higher fatty acid and continuous 3 week of diet hypercholesterolemia simultaneously, and the level of the former cholesterol in serum is higher 2 times than the latter.And the former cholelithiasis occurs, and this situation appears in latter end, shows that the ACAT enzyme is a up-and-coming medicine.6. cholesterol fracture activated protein (SCAP) part, this compounds directly be positioned at the endocytoplasmic reticulum film on the sterin fracture activated protein of cholesterol regulation element conjugated protein directly combine increase IDL receptor expression.The SCAP part improves the cholesterol of animal model and the level of glycerol three cheese is better than HMG-CO people's reductase inhibitor-statins.

From as seen above-mentioned, though Western medicine has effect faster to treatment hyperlipidemia and cholesterol, a lot of side effect, particularly statins are arranged, what have becomes safety issue the most troubling and concern.

Angle from the traditional Chinese medical science, the tradition traditional Chinese medical science is thought, fatty liver is many because of eating and drinking without temperance or have a liking for food delicious food savoury and physical factors etc. and cause the liver defluidization to be let out, and dysfunction of the spleen in transportation forms that stagnation of liver-QI with deficiency of the spleen, wet knot expectorant coagulate, the card of stasis of blood resistance blood network, belongs to motherland's medical science " hypochondriac pain ", " gathering " category.Be the deficiency in origin and excess in superficiality card, sick position is dirty at liver spleen two, with the passing of time involves in kidney, shows as liver,spleen,kidney three dirty deficiencies, and its pathological factor is gas, blood, expectorant, wet, resistance.Control and to adopt the method for hepar sulfuris spleen invigorating, nourishing yin for softening liver, dispelling phlegm and eliminating dampness, phlegm reduction of blood circulation promoting at its pathogenic characteristic.Traditional Chinese medical science ancient books has many proved recipes, if any mention Rhizoma Atractylodis Macrocephalae invigorating the spleen and benefiting QI dampness removing, the Radix Salviae Miltiorrhizae activating blood circulation to dissipate blood stasis and dredge the collateral is monarch drug altogether; Radix Curcumae, Semen Cassiae hepar sulfuris are regulated the flow of vital energy; Flos Carthami helps Radix Salviae Miltiorrhizae blood-activating and qi-promoting, disperse blood stasis and dredge collateral; Fructus Lycii, the Radix Polygoni Multiflori are strengthened the merit of invigorating spleen to remove dampness, nourishing yin for softening liver; The Folium Nelumbinis dampness removing that reduces phlegm; The Fructus Crataegi removing food stagnancy is capable to stagnate; Radix Et Rhizoma Rhei stasis removing, eliminate indigestion eliminating stagnation; The Herba Sedi clearing away heat-damp and promoting diuresis.All medicines share, and play altogether and protect the liver spleen invigorating, the effect of the dampness removing that reduces phlegm, promoting blood circulation to remove obstruction in the collateral, blood stasis-eliminating and stagnation-dissipating, and treating both the principal and secondary aspects of a disease makes spleen must be good for fortune, liver and can sulfur lets out, wetly goes expectorantization, Fructus Schisandrae Chinensis to have effects such as anti-hepatic injury, antioxidation, enhance immunity and liver detoxification function; Fructus Crataegi can quicken the removing of blood fat; Radix Et Rhizoma Rhei liver heat removing function of gallbladder promoting, stasis removing, invigorating blood circulation are strongly fragrant, and it is synthetic and suppress effect such as rising to have a lipid of interference; Radix Salviae Miltiorrhizae is a kind of blood-activating and stasis-removing, has microcirculation improvement, increases effects such as capillary network, can also remove free radical, has calcium antagonism, and it is stable to keep intracellular Ca2+, thereby brings into play the effect of its anti-hepatic necrosis.The link closely etiology and pathogenesis of fatty liver of the proved recipe that has, the coupling of many methods, treating both the principal and secondary aspects of a disease, and in conjunction with the modern medicine study achievement, according to the pathogenesis of fatty liver, select the medicine prescription pointedly, obtaining significant curative effect aspect the improvement of symptom and sign, liver function and the blood fat reducing.

It is as follows to retrieve Chinese patent related to the present invention and technical journal:

1, Chinese patent＜application number〉97101570＜denomination of invention〉thrombus-eliminating and brain-invigorating capsule＜applicant〉Hao Yongxin＜contact address〉Liaoyang City, Liaoning Province 19 innings of central hospital＜claim of road ferrum of defending the country〉thrombus-eliminating and brain-invigorating capsule relates to a kind of Chinese medicine preparation for the treatment of cerebral thrombosis, trematodiasis 300 grams, Radix Ginseng 250 grams, eupolyphage sece steleophaga 800 grams, Pheretima 250 grams, Rhizoma Chuanxiong 500 grams is characterized in that fetching water, the said medicine weighing is assorted, it is qualified to concoct, be processed into 100 order powder, incapsulate.＜summary〉thrombus-eliminating and brain-invigorating capsule relates to a kind of Chinese medicine preparation for the treatment of cerebral thrombosis, mainly be for the Chinese medicine that solves existing treatment cerebral thrombosis based on the plant amedica source, weak curative effect is developed treating the worse problem of numb effect.The present invention mainly with Hirudo, Radix Ginseng, eupolyphage sece steleophaga, Pheretima, Rhizoma Chuanxiong and Scolopendra, Radix Et Rhizoma Rhei, Zaocys etc., to also have Semen Cassiae, Formica fusca etc. be raw material, formulated, the treatment cerebral thrombosis is controlled numbness, lipid-lowering effect is very good.

2, Chinese patent＜application number〉95121615＜denomination of invention〉a kind of Chinese medicine preparation＜applicant of reducing fat and dilating coronary artery〉Zhang Baosen, He Lanfeng＜contact address〉No. 62＜summary in Qing Yuan street, Shijiazhuang City, Hebei Province city〉a kind of Chinese medicine preparation of reducing fat and dilating coronary artery, it is characterized in that following finished product Chinese medicine (weight is gram) fully: Radix Astragali 300-400 Herb Gynostemmae Pentaphylli 300-400 Herba Epimedii 100-200 Fructus Ligustri Lucidi 100-200, mix after boil and carry, precipitate with ethanol, concentrate, obtain extracting solution.In extracting solution, add zinc gluconate, sodium selenite etc. and add ingredients, through leave standstill, packing and sterilization, promptly obtain this preparation.This preparation has effects such as blood fat reducing, strong kidney and strengthening spleen.

3, Chinese patent＜application number〉00133594＜denomination of invention〉hypolipemic ' Tongluowan '＜applicant〉Wang Zhigang＜contact address〉Da Tun township, Qingfeng County, Henan Province assembles East St clinic＜summary greatly〉a kind of medicine that cures mainly cardiovascular and cerebrovascular vessel, it is by Rhizoma Gastrodiae, Agkistrodon, Semen Persicae, Rhizoma Chuanxiong, Hirudo, Fructus Crataegi, the Radix Astragali, Ramulus Cinnamomi, Radix Salviae Miltiorrhizae is main medicine, it is the medicine of blood fat reducing collateral dredging, wherein adopt Agkistrodon, Rhizoma Gastrodiae, the Hirudo activating blood circulation to dissipate blood stasis, the medicine principle of Fructus Crataegi blood fat reducing cooperates realization, cost of the present invention is low, the curative effect height, more do not recur after, curing effective percentage can reach more than 87%.

4, Chinese patent＜application number〉03153559＜denomination of invention〉health promoting beverage＜applicant〉Gao Si＜contact address〉No. 62 3 unit of East Village, mud hilllock, Luohu District, Shenzhen City, Guangdong Province 106 Room＜summaries〉the invention discloses one group of several health promoting beverage, be primarily aimed at hyperlipidemia, high blood viscosity, atherosclerosis, coronary heart disease, easy hemopoietic bolt high-risk group and fat personage the diet-therapy health-preserving opsonic action is arranged, suitably take into account the needs of diabetics and prophylaxis of cancer, health promoting beverage is taken good care of in custom-designed daily dietetic therapy.It is made by following twenty kind of natural medicine-food homology raw material choice: Ganoderma, Flos Lonicerae, Fructus Crataegi, Folium Nelumbinis, the Radix Astragali, Folium Camelliae sinensis, Folium Stevlae Rebaudianae, the Rhizoma Atractylodis Macrocephalae, Rhizoma Polygonati, Rhizoma Alismatis, Herb Gynostemmae Pentaphylli, Fructus Ligustri Lucidi, Radix Salviae Miltiorrhizae, Radix Ginseng, Radix Notoginseng, Fructus Lycii, Fructus Corni, Rhizoma Chuanxiong, Radix Rehmanniae Preparata, Radix Angelicae Sinensis, its common feature is: adopt natural material, be processed into one group of plesiomorphic beverage of taste, suitability for industrialized production is transported, stores, is drunk conveniently.Often drink, conditioning lipid metabolism, blood fat reducing are all arranged, fall sticking, the pre-preventing thrombosis of blood and coronary heart attack and atherosclerosis, reach gradually and suppress body weight gain and reduce fat effect, normal drink has no side effect.

5, Chinese patent＜application number〉03114248＜denomination of invention〉a kind of blood fat reducing and slow down aging pharmaceutical composition and medicine＜applicant〉Shenzhen Haiwang Pharmaceutical Co., Ltd＜contact address〉25 layers of Building A, Haiwang Building, Nanyou Avenue, Nanshan District, Shenzhen City, Guangdong Province＜summary〉compositions and the preparation thereof of Chinese medicine drug extract of a kind of effectively blood fat reducing and slow down aging, said composition is the dried leaves extract that contains Semen Ginkgo, the dry root and rhizome extract of Radix Rhodiolae, the medicament of the dry mature fruit extract of Fructus Schisandrae Chinensis, by weight, described Folium Ginkgo extract, Radix Rhodiolae extract, the extract combination ratio of Fructus Schisandrae Chinensis is: Folium Ginkgo extract: Radix Rhodiolae extract=1: 0.5～2: 0.75～3, have defying age and blood fat reducing function, taking convenience, tool health-care effect and the characteristics that have no side effect.

6, Chinese patent＜application number〉02146744＜denomination of invention〉the Chinese medicine electuary＜applicant of blood fat reducing〉Wang Wei＜contact address〉king top, Nankai District, Tianjin City dike Rong Qian Dongli 14-5-503 number,＜summary〉a kind of Chinese medicine electuary of blood fat reducing, form by following component ratio: by weight, Rhizoma Cyperi 1-3 part, Fructus Aurantii 2-4 part, Fructus Gardeniae 4-6 part, Radix Bupleuri 2-4 part, Rhizoma Chuanxiong 5-6 part, Fructus Schisandrae Chinensis 4-7 part, Semen Cassiae 2-5 part, Fructus Crataegi 5-8 part, Cortex Mori 3-6 part, Folium Perillae 2-4 part, Ramulus Cinnamomi 5-7 part; More than every medicine be crushed into powder and be mixed in proportion.Effect of the present invention is: through clinical confirmation in large quantities, it can be when reducing blood viscosity vessel softening, around improving and the circulation of cardiovascular and cerebrovascular vessel, improve the body constitution function, reduce glyceride, promote the lipase function, thus the blood fat reducing viscosity.

7, fat soup treatment fatty liver 90 examples [author] Zhang Jianwei of intending certainly dispelling turns round and look at the Shaanxi traditional Chinese medical science .2002 of brave main [mechanism] Zhongshan Hospital Attached to Fudan Univ [periodical name], 23 (1) .[digests] purpose: the curative effect of observing the treatment by Chinese herbs fatty liver.Method: adopt from intending fat soup (Fructus Crataegi, Radix Salviae Miltiorrhizae, Rhizoma Alismatis, Semen Cassiae, Rhizoma Polygoni Cuspidati, Folium Nelumbinis etc.) treatment fatty liver 90 examples of dispelling, result: total effective rate 91.11%.Through Ridit and t check, change relatively before and after fatty liver, the hyperlipidemia treatment, the P value is respectively＜and 0.05,＜0.01.Short term effect is satisfied.Point out this method to have lowering fat and protecting liver, improve liver, activate the drawback that lipoprotein enzyme Western medicine decreases liver and have for the effect of penetrating.

8, capsule for descend of blood fat is treated [mechanism] Jingjiang City, Jiangsu Province institutes of traditional Chinese medicine such as the virtuous Liu Can health of hyperlipemia 180 routine observation of curative effect [author] He Jing, [periodical name] Jilin Chinese medicine .2002,22 (1) .[digests] purpose: observe the curative effect of capsule for descend of blood fat to hyperlipemia.Method: treatment is organized 180 examples and is given capsule for descend of blood fat, and matched group 90 examples give oral inositol cigarette ester sheet.Observe treatment front and back TC, TG, HDL-C changes of contents.Result: TC, TG, HDL-C changes of contents compare P all＜0.05 before and after 2 groups of treatments, compare P＜0.05 after treatment group and the treatment of control group; Treatment group total effective rate is 93.33%, and the matched group total effective rate is 68.89%, P＜0.05.Conclusion: by reducing the absorption and the increase of lipid are drained the decomposition of lipid by the capsule for descend of blood fat that Fructus Crataegi, Semen Cassiae, Radix Polygoni Multiflori, Rhizoma Alismatis, Radix et Rhizoma Rhei (processed), Radix Angelicae Sinensis, Fructus Lycii etc. are formed, play altogether and let out turbid blood stasis dispelling, the effect of tonifying speen and tonifying kidney, reach the purpose of adjusting blood fat, every curative effect index all obviously is better than matched group.

9, the Henan College Of Traditional Chinese Medicine journal .2003 of blood fat reducing soup treatment hyperlipemia 52 routine clinical research [author] Sun Yongli [mechanism] the Shanghai City Zhabei District hospitals of traditional Chinese hospital [periodical name], 18 (4) .[digests] blood fat reducing soup is made up of medicines such as Semen Cassiae, Fructus Crataegi (parched to brown), Flos Chrysanthemi, Flos Carthami, Radix Polygoni Multiflori, Radix Salviae Miltiorrhizae, Radix Et Rhizoma Rhei, Rhizoma Alismatis.Clinical treatment group 52 examples are taken blood fat reducing soup, produce effects 34 examples, effective 14 examples, invalid 4 examples, effective percentage 92.30%; Matched group 38 examples are taken many rare Weikang capsule for curing, produce effects 15 examples, effective 12 examples, invalid 11 examples, effective percentage 71.05%.

10, transfer the safe Chen Yu brightness Zhou Ying [mechanism] of the strong liver soup treatment of fat fatty liver 60 routine clinical observation [author] the Yang Fu hospital of traditional Chinese hospital, Tianhe District, Guangzhou City, Guangdong Province, [periodical name] new traditional Chinese medical science .2004,36 (3) .-39-40[digests] purpose: observe the curative effect of transferring the strong liver soup treatment of fat fatty liver.Method: 105 routine patients are divided into treatment group and matched group at random.60 examples are organized in treatment, and the strong liver soup of fat (prescription: Fructus Crataegi, Radix Polygoni Multiflori, Radix Salviae Miltiorrhizae, Poria, Pericarpium Citri Reticulatae, Rhizoma Alismatis, Endothelium Corneum Gigeriae Galli, stir-fry Rhizoma Curcumae, Rhizoma Pinelliae Preparatum, Semen Cassiae, Rhizoma Curcumae Longae, Radix Notoginseng end) of transferring for oral administration is treated; Matched group 45 examples, oral Herb Gynostemmae Pentaphylli total glycosides tablet, inosine sheet.The result: treatment group produce effects 20 examples, effective 37 examples, invalid 3 examples, total effective rate is 95.0%: matched group produce effects 7 examples, effective 25 examples, invalid 13 examples, total effective rate is 71.1%.2 groups of total effective rates compare, and difference has highly significant meaning (P＜0.01).Conclusion: transfer the strong liver soup of fat can promote the metabolism of liver inner lipid effectively, lipid reducing and regulating has the good curing effect to fatty liver.

From above-mentioned data searching, still have morely with the data of Chinese herbal treatment hyperlipemia, they respectively have characteristics, and its major function is vessel softening when reducing blood viscosity, around improving and the circulation of cardiovascular and cerebrovascular vessel.

Summary of the invention

The inventor is on the basis of secret prescription handed down in the family from generation to generation, at people in the modern life usually because diet do not note and work, live and social pressure, cause hyperlipidemia and cholesterol easily, cause the generation utilization Chinese medical theory of arteriosclerosis and cardiovascular disease more preferred Chinese medicines, make the health preparation of a kind of blood fat reducing and cholesterol, to health care fill a prescription in addition the science compatibility, make that each medicine cooperatively interacts, learns from other's strong points to offset one's weaknesses, synergism, make it to produce maximum effect, given play to due usefulness.

The health preparation that the present invention has blood fat reducing and cholesterol is to be made by the raw material of Chinese medicine of following mass fraction:

Fructus Crataegi 10-20

Herba Lophatheri 10-20

Semen Cassiae 12.5-25

Rhizoma Alismatis 17.5-35

The health preparation raw material of blood fat reducing of the present invention and cholesterol is through the modern science analysis, has needed by human body number of chemical composition, as: triterpenoid, arundoin, Cylindrin, match alcohol, left-handed epicatechin, Quercetin, hyperin, chlorogenic acid, citrate, emodin, obtusin, betanin, volatile oil, alkaloid, asparagine and polytype polysaccharide, multivitamin, various trace elements, inorganic elements, nicotinic acid, multiple soap is sweet, citric acid sheep formicester, flavan polymers, ursolic acid, glucosan, alkanoic acid glyceride etc.

The health preparation raw material of above-mentioned blood fat reducing and cholesterol can be from " finding its another name, latin name and the place of production, usage Chinese pharmacopoeia and other Chinese medicine handbook, for understanding the mechanism of the present invention's prevention and inhibition disease, now provide the effect and the pharmacological thereof of the Chinese medicine of respectively distinguishing the flavor of in the prescription:

(1) Fructus Crataegi: sour in the mouth, sweet, slightly warm in nature.Digestion-promoting spleen-invigorating, promoting blood circulation to remove blood stasis, diuresis, enhancing immunity, antibiotic, antioxidation, anti-cancer.Fructus Crataegi comes from China, is the exclusive seeds of China, and the fruit vitamin C is higher, more contains multiple nutrients composition (flavone, protein, potassium, calcium, ferrum, zinc, manganese, magnesium, phosphorus etc.), has more than 80 kind of Chinese patent medicine to be unable to do without simultaneously and does raw material with Fructus Crataegi.Particularly contain blood fat reducing and cholesterol effect, be subjected to the great attention of domestic and international medical circle, show through animal experiment, Fructus Crataegi can be improved the hormone-sensitive lipase activity significantly, quickens lipid mobilization and promotes the gastrointestinal wriggling.The fat-reducing test shows, can suppress the increase of nutrition obese type rat body weight significantly, reduces the volume of adipose cell, alleviates body fat quality and blood fat reducing level, has fat-reducing effect preferably.

(2) Herba Lophatheri, Herba Lophatheri are the dry stem and leaf of grass Herba Lophatheri, and the beginning is stated from Compendium of Material Medica, and " Chinese pharmacopoeia is all recorded to go through version.The dried root of Herba Lophatheri is elongated spindle, microbend, long 1-4cm, and diameter 0.2-0.5cm, surperficial yellow-white have irregular wrinkle to khaki, meat slightly, section is talked yellow-white, and it is little sweet to distinguish the flavor of.Herba Lophatheri sweet in the mouth, light, cold in nature, GUIXIN, stomach, small intestine meridian, tool clearing heat and relieving fidgetness, diuretic effect.Be used for the calentura excessive thirst, hot urination drenches pain, and aphtha of the mouth and tongue etc. belong to conventional Chinese medicine.Stem, leaf contain trisulfide, acid ingredient, aminoacid, organic acid and saccharide etc., also are one of the most frequently used medical herbs among the people, have both made medicine, make the health care herbal tea of relieving summer heat again, and it all has fabulous DEVELOPMENT PROSPECT at aspects such as medicinal, health-care tea beverages.Herba Lophatheri is used as medicine later, and Ming Dynasty's Compendium of Material Medica beginning is seen record.Li Shizhen (1518-1593 A.D.) claims it: sweet, cold, nontoxic.Leaf: go dysphoria with smothery sensation, diuresis clears away heart-fire.Root: the name Rhizoma lophantheri, can have an abortion to expedite the emergence of.Record among the people, Herba Lophatheri are clearing away heart-fires simply, heat clearing away and restlessness relieving, and the good medicine of diuresis, thirsty to the treatment calentura, vexed uneasiness, the erosion of the oral mucosa tongue boil, tooth swells and ache age, and hot urination drenches pain, and effect is quite arranged.The contained functional component of Herba Lophatheri mainly is: trace element such as flavone, phenolic acid compound, aminoacid, ferrum, manganese, zinc.Related data shows: these effective ingredient can be removed activity in vivo oxygen-derived free radicals (it can impel people's aging); Blocking nitrosamine formation is synthetic; Induce the activity of the antioxidase system of organism inside; The anti-stress of enhancing body and anti-fatigue ability; Improve memory ability, the process of slow down aging etc.Can also protect medicament as cardiovascular and cerebrovascular vessel, antitumor drug etc.Also can use simultaneously at aspects such as health product, functional drinkss.

(3) Semen Cassiae is Semen Cassiae again, is the dry mature seed of leguminous plant Semen Cassiae or little Semen Cassiae, and nature and flavor are sweet, bitter, salty, be slightly cold, and returns liver, large intestine channel, and the effect of liver heat removing and eyesight improving, diuretic relieving constipation is arranged.Modern study shows, pharmacological action such as Semen Cassiae protects the liver, makes eye bright, blood pressure lowering, blood fat reducing.Naturally drink of the influence of the Semen Cassiae water decoction of variable concentrations under the physiological status to the alimentary obesity rat body weight, found that the Semen Cassiae water decoction of 6% concentration can obviously suppress the increase of alimentary obesity rat body weight, and do not influence appetite, there is not the diarrhoea effect that causes, has health-care effect preferably, bibliographical information is arranged, observe under the rat physiological status and drink of the influence of Semen Cassiae water decoction naturally, and tentatively inquire into its mechanism of action the alimentary obesity body weight.Method: make the obese rat model with high nutrient fodder, allow rat under physiological status, drink the Semen Cassiae water decoction of variable concentrations naturally, observe its influence to rat body weight and sugar, lipid metabolism and lipoid peroxidization resistant.The result: the Semen Cassiae water decoction of 6% concentration can obviously reduce body weight, Lee ' s index, empty stomach serum triglycerides, insulin and the mda content of alimentary obesity rat, free fatty acid content also has downward trend, and the Total antioxidant capacity level has rising trend.Conclusion: the Semen Cassiae water decoction can obviously suppress the increase of alimentary obesity rat body weight, and its mechanism of action may be relevant with its adjusting glucose and lipid metabolism.

(4) Rhizoma Alismatis, Rhizoma Alismatis are the dry tuber of Alismataceae plant Rhizoma Alismatis Alisma orientalis (Sam.) Juzep..Cold in nature, sweet in the mouth, light is returned kidney, urinary bladder channel.The effect that have promoting diuresis to eliminate damp pathogen, expels the heat-evil.Be used for dysuria, edema distension, have loose bowels, disease such as oliguria, phlegm retention, dizzy, puckery pain of pyretic stranguria.The application of Rhizoma Alismatis in recent years is very extensive, pharmacological action, and 1. Rhizoma Alismatis has tangible diuresis, and to contain a large amount of potassium salt relevant with it for this.2. blood fat reducing and study of anti-atherogenic effect, Rhizoma Alismatis can obviously reduce serum total cholesterol, triglyceride, promote serum, level raises, obviously suppress the generation of aortic tunica intima speckle, in addition, Rhizoma Alismatis extract also has antiplatelet aggregation, antithrombotic to form and strengthens effect such as plasmin activity, thus can be from blood fat reducing, suppress many-side inhibition such as endothelial cell damage, antithrombotic or alleviate atherosclerotic generation, development.3. lipotropy, Rhizoma Alismatis all has good effect through the component of methanol, benzene and acetone extraction to the Animal fat liver that a variety of causes causes, fatty liver due to low protein diet, the ethionine all there is in various degree inhibitory action, 4. hypotensive activity, Rhizoma Alismatis and extract thereof have hypotensive effect to a certain degree.5. to immune influence and antiinflammatory action, the Rhizoma Alismatis decoct is given the mouse peritoneal injection with 10g/Kg, 20g/Kg, continuous 5 days, discovery can suppress the mice carbon powder and clean up speed and 2, contact dermatitis due to the 4-dinitrochlorobenzene, and content of ascorbic acid in serum antibody level and the rat adrenal gland is not made significant difference; The Rhizoma Alismatis decoct then can obviously alleviate the mice auricle swelling that dimethylbenzene causes with the 20g/kg intraperitoneal administration, suppresses rat granuloma hamartoplasia, and the prompting Rhizoma Alismatis has antiinflammatory action.

The mechanism of action of blood fat reducing of the present invention and cholesterol health preparation is:

Except operating pressure and factor of environmental, the urbanization of the higher fatty acid and modern inhabitation of food at present, make person in middle and old age's disease incidence in rising trend, for example serious threat human health, cardiovascular and cerebrovascular disease has risen to three human big diseases, relevant hyperlipidemia, hyperglycemia, hypercholesterolemia and cause coronary heart disease and the research of atheromatosis aspect has become clinical and focus basic research, therefore, preventing cardiovascular disease and restrain tumor, is an outstanding feature of the present invention.The inventor studies Traditional Chinese medical theory, on the basis of secret prescription handed down in the family from generation to generation, replenished and put in order, excavate and develop and a kind of plurality kinds of health care Chinese medicine is share, the deficiency of vital energy can be mended, blood stasis can loose, and wind-phlegm can be dispelled, suppressing the hyperactive liver and subsiding YANG, play benefiting QI for activating blood circulation altogether, eliminating phlegm relieves dizziness, high fever, infantile convulsions, epilepsy, etc., disperse blood stasis and dredge collateral, treating both the principal and secondary aspects of a disease it, it can improve myocardial function, blood vessel dilating, blood fat reducing, blood sugar lowering, cholesterol reducing alleviates atherosclerosis, strengthen human body cell metabolism number of times prolonged human body life time, slow down aging and the imbalance of adjusting viscera function suppress body building health preparation of tumor and preparation method thereof.The characteristic that the present invention has is as follows:

(1) slightly warm in nature, digestion-promoting spleen-invigorating, promoting blood circulation to remove blood stasis, diuresis, enhancing immunity.Each organ function equilibrium of conditioning human body viscera improves body immunity, effective two-ways regulation human immunity state, and the resist the disease factor, and harmful pathogenic bacteria is invaded human body.

(2) induce the activity of the antioxidase system of organism inside; The anti-stress of enhancing body and anti-fatigue ability; Improve memory ability, the process of slow down aging can be used as cardiovascular and cerebrovascular vessel protection medicament, and antitumor drug etc. are induced the activity of the antioxidase system of organism inside; The anti-stress of enhancing body and anti-fatigue ability; Improve memory ability, the process of slow down aging etc.Can also protect medicament as cardiovascular and cerebrovascular vessel, antitumor drug etc.

(3) protect the liver, make eye bright, blood pressure lowering, blood fat reducing, promote the human body metabolism to make human nerve, endocrine operational network normal.Improve myocardial function, blood vessel dilating brings high blood pressure down, and promotes hemopoietic function, blood fat reducing, and blood sugar lowering, cholesterol reducing alleviates atherosclerosis, and blood circulation promoting and blood stasis dispelling impels blood leukocytes and hemoglobin to increase, and wound healing is fast.

So, blood fat reducing of the present invention and cholesterol health preparation have been followed whole existing the thought and the determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs principle of motherland's medical science, the rule of development takes place in research and inquirement hypertension theoretically, hyperlipidemia, and adopt blood circulation promoting and blood stasis dispelling, hard masses softening and resolving, heat-clearing and toxic substances removing, the body resistance strengthening and constitution consolidating etc. to have " operation " means of Chinese medicine characteristic, accomplish " medication is as using military forces ", ability " To know one's own strength and the enemy's is the sure way to victory "

Above-mentioned composition can be used as middle age prevention hyperlipidemia, hypercholesterolemia, supression fatty liver and causes coronary heart disease and the health preparation of atheromatosis, also can be used as hospital's prescription, provides patient to fry in shallow oil soup and takes.Be more suitable for modern pharmaceutical enterprise and extract its effective ingredient, make any dosage form of health product such as capsule, granule, oral liquid, concrete production method is as follows:

1, the production method of capsule:

(1) get Fructus Crataegi, Herba Lophatheri, Semen Cassiae, Rhizoma Alismatis, mixing and pulverize, cross 80 mesh sieves, add clear water and boiled 10-30 minute, filter, boil again, totally twice, preserve filtrate A;

(2) with the alcohol reflux twice of filtering residue with volume by volume concentration 55-70%, each 2-3 hour, extracting solution reclaimed ethanol and gets alcohol extraction part B;

(3) A and B mixing are concentrated, get relative density 1.05-1.20/55-60 ℃ fluid extract, spray drying gets intermediate products dried cream powder C;

(4) get C and appropriate amount of auxiliary materials (by the adjuvant of state-promulgated pharmacopoeia regulation) mixing, granulate, encapsulated dress gets the finished capsule product agent.

2, granule production method;

(1) get Fructus Crataegi, Herba Lophatheri, Semen Cassiae, Rhizoma Alismatis, mixing and pulverize, cross 80 mesh sieves, add clear water and boiled 10-30 minute, filter, boil again, totally twice, preserve filtrate A;

(2) with the alcohol reflux twice of filtering residue with volume by volume concentration 55-70%, each 2-3 hour, extracting solution reclaimed ethanol and gets alcohol extraction part B;

(3) A and B mixing are concentrated, get relative density 1.05-1.20/55-60 ℃ fluid extract, spray drying gets intermediate products dried cream powder C;

(4) get C and appropriate amount of auxiliary materials (by the adjuvant of state-promulgated pharmacopoeia regulation) mixing, granulate, drying, packing gets the finished particle agent.

3, oral liquid production method;

(1) get whole Fructus Crataegis, Herba Lophatheri, Semen Cassiae, Rhizoma Alismatis mixing pulverizing, with the alcohol reflux twice of volume by volume concentration 55-70%, each 2-3 hour, extracting solution reclaimed ethanol and gets the alcohol extraction part A;

(2) medicinal residues after the above-mentioned alcohol extraction and Fructus Crataegi, Herba Lophatheri, Semen Cassiae, Rhizoma Alismatis are added 5-8 times of water gaging decoction twice, each 2-3 hour, get water and carry part B:

(3) A and B mixing are concentrated, get relative density 1.05-1.20/55-60 ℃ fluid extract, add an amount of syrup or Mel mixing, sterilization gets the finished product oral liquid.

4, the manufacture method of teabag

The manufacture method of teabag is to get Chinese medicine mix homogeneously such as Fructus Crataegi, Herba Lophatheri, Semen Cassiae, Rhizoma Alismatis, pulverizes 80 mesh sieves, adds 5 times of tea packagings; Perhaps add Folium Ginkgo, pulverize, packing is made teabag.

5, the production method of pill:

(1) get Fructus Crataegi, Herba Lophatheri, Semen Cassiae, Rhizoma Alismatis, mixing and pulverize, cross 80 mesh sieves, add clear water and boiled 10-30 minute, filter, boil again, totally twice, preserve filtrate A;

(2) with the alcohol reflux twice of filtering residue with volume by volume concentration 55-70%, each 2-3 hour, extracting solution reclaimed ethanol and gets alcohol extraction part B;

(3) A and B mixing are concentrated, get relative density 1.05-1.20/55-60 ℃ fluid extract, spray drying gets intermediate products dried cream powder C;

(4) get C and Mel and adjuvant (by the adjuvant of state-promulgated pharmacopoeia regulation) mixing, also filtering residue can be added, stir, make pill, and make it dry, coating promptly obtains product.

6, tablet manufacturing method:

(1) get Fructus Crataegi, Herba Lophatheri, Semen Cassiae, Rhizoma Alismatis, mixing and pulverize, cross 80 mesh sieves, add clear water and boiled 10-30 minute, filter, boil again, totally twice, preserve filtrate A;

(2) with the alcohol reflux twice of filtering residue with volume by volume concentration 55-70%, each 2-3 hour, extracting solution reclaimed ethanol and gets alcohol extraction part B;

(3) A and B mixing are concentrated, get relative density 1.05-1.20/55-60 ℃ fluid extract, spray drying gets intermediate products dried cream powder C;

(4) get C and appropriate amount of auxiliary materials (by the adjuvant of state-promulgated pharmacopoeia regulation) mixing, granulate, tabletting, packing gets finished tablet.

The instructions of taking of the health preparation of the present invention's blood fat reducing of the present invention and cholesterol:

Capsule, every day three times, each 3, every 0.5 gram; Granule, every day three times, each 1 bag, every bag 7 gram; Oral liquid, every day three times, each 10ml; Tablet, every day three times, each 2-3 sheet, every 0.3 gram.Patient doubles, and the child quantitatively takes according to body weight and adult's ratio.Other preparation is taken as the case may be.

The present invention compared with the prior art, its outstanding substantive distinguishing features and obvious improvement is:

1, the present invention's more preferred raw material of Chinese medicine with blood fat reducing and cholesterol health preparation commonly used under Chinese medical theory instructs, science compatibility, making in addition, make that each raw material cooperatively interacts, learns from other's strong points to offset one's weaknesses, synergism, all medicines share, the deficiency of vital energy can be mended, and blood stasis can loose, and wind-phlegm can be dispelled, suppressing the hyperactive liver and subsiding YANG is played benefiting QI for activating blood circulation, the effect of the eliminating phlegm that relieves dizziness, high fever, infantile convulsions, epilepsy, etc., disperse blood stasis and dredge collateral, treating both the principal and secondary aspects of a disease altogether.

2, through clinical verification, the present invention can suppress, eliminate atherosclerosis, suppresses hypercholesterolemia and hyperlipidemia, the promoting blood circulation thrombus dissolving, the infractionization that disappears high blood viscosity, anti-platelet aggregation is unusual, antihypertensive can improve the cerebrovascular metabolic function, the resisting cerebrovascular sclerosis, it is capable to improve blood, and activating brain cell and brain function can be used for premonitory apoplexy, apoplexy sequela, the thoracic obstruction, also can be used for coronary heart disease, angina pectoris, high blood viscosity, hyperlipemia etc., treat the disease spectrum width, with strong points, evident in efficacy.

3, from the angle analysis of modern medicine, the present invention has the pathological changes that alleviates ischemic rat brain, reduces the permeability of cerebral tissue blood capillary and the water content of cerebral tissue, anticoagulant and thrombosis, cerebral blood flow increasing amount and oxygen-supplying amount, functions such as blood lipid reducing, blood sugar concentration.

4, raw material is easy to get, the prescription science, and production technology advanced person, workable, moderate product price is fit to suitability for industrialized production.

5, produce in according to the effective ingredient character and the preparation requirement of each flavor raw material of Chinese medicine, adopt or alcohol extraction, or water carries, or the production technology of pulverizing and corresponding sterilizing methods, thereby product active constituent content height, and not perishable long shelf-life.

6, the result of product studies on acute toxicity of the present invention and long term toxicity research shows, is safe by intending using product of the present invention the course of treatment with daily dose.

The specific embodiment

Below be embodiments of the invention:

Embodiment one

(1) take by weighing Fructus Crataegi 20 gram, Herba Lophatheri 20 grams, Semen Cassiae 25 grams, Rhizoma Alismatis 35 grams mix and pulverize, and cross 80 mesh sieves, add 2500 milliliters of clear water and boil 10-30 minute, filter, boil again, totally twice, preserve filtrate A;

(2) with the alcohol reflux twice of filtering residue with volume by volume concentration 55-70%, each 2-3 hour, extracting solution reclaimed ethanol and gets alcohol extraction part B;

(3) A and B mixing are concentrated, get relative density 1.05-1.20/55-60 ℃ fluid extract, spray drying gets intermediate products dried cream powder C;

(4) get C and appropriate amount of auxiliary materials (by the adjuvant of state-promulgated pharmacopoeia regulation) mixing, granulate, encapsulated dress gets hundred million yuan of blood fat reducing capsules of product.

Embodiment two:

(1) get Fructus Crataegi 18 gram, Herba Lophatheri 16 grams, Semen Cassiae 22 grams, Rhizoma Alismatis 25 grams mix and pulverize, and cross 80 mesh sieves, add 3000 milliliters of clear water and boil 10-30 minute, filter, boil again, totally twice, preserve filtrate A;

(2) with the alcohol reflux twice of filtering residue with volume by volume concentration 55-70%, each 2-3 hour, extracting solution reclaimed ethanol and gets alcohol extraction part B;

(3) A and B mixing are concentrated, get relative density 1.05-1.20/55-60 ℃ fluid extract, add 2 times of syrup, wiring solution-forming, sterilization gets hundred million yuan of oral administration liquor for reducing blood fat of finished product.

Embodiment three:

(1) get Fructus Crataegi 20 gram, Herba Lophatheri 20 grams, Semen Cassiae 25 grams, Rhizoma Alismatis 35 grams, mix and pulverize, cross 80 mesh sieves, add 2000 milliliters in clear water and boiled 10-30 minute, filter, boil again, totally twice, preserve filtrate A;

(2) with the alcohol reflux twice of filtering residue with volume by volume concentration 55-70%, each 2-3 hour, extracting solution reclaimed ethanol and gets alcohol extraction part B;

(3) A and B mixing are concentrated, get relative density 1.05-1.20/55-60 ℃ fluid extract, spray drying gets intermediate products dried cream powder C;

(4) get C and appropriate amount of auxiliary materials (by the adjuvant of state-promulgated pharmacopoeia regulation) mixing, granulate, drying, packing gets hundred million yuan of blood fat reducing granules of finished product.

Embodiment four:

(1) get whole Fructus Crataegis 20 grams, Herba Lophatheri 20 grams, Semen Cassiae 25 grams, Rhizoma Alismatis 35 grams, mix and pulverize, with the alcohol reflux twice of volume by volume concentration 55-70%, each 2-3 hour, extracting solution reclaimed ethanol and gets the alcohol extraction part A;

(2) medicinal residues after the above-mentioned alcohol extraction and Fructus Crataegi, Herba Lophatheri, Semen Cassiae, Rhizoma Alismatis are added 5-8 times of water gaging decoction twice, each 2-3 hour, get water and carry part B;

(3) A and B mixing are concentrated, get relative density 1.05-1.20/55-60 ℃ fluid extract, spray drying gets intermediate products dried cream powder C;

(4) get dried cream powder C, with appropriate amount of auxiliary materials (by the adjuvant of state-promulgated pharmacopoeia regulation) mixing, granulate, sugar coating gets hundred million yuan of blood fat reducing coated tablets of finished product.

Embodiment five:

Get Fructus Crataegi 16 grams, Herba Lophatheri 16 grams, Semen Cassiae 20 grams, Rhizoma Alismatis 28 grams, four kinds of Chinese medicine mix homogeneously were pulverized 80 mesh sieves, added 5 times of tea packagings; Perhaps add Folium Ginkgo, pulverize, packing is made teabag.

Embodiment six:

(1) get Fructus Crataegi 15 gram, Herba Lophatheri 15 grams, Semen Cassiae 19 grams, Rhizoma Alismatis 33 grams, mix and pulverize, cross 80 mesh sieves, add clear water and boiled 10-30 minute, filter, boil again, totally twice, preserve filtrate A;

(2) with the alcohol reflux twice of filtering residue with volume by volume concentration 55-70%, each 2-3 hour, extracting solution reclaimed ethanol and gets alcohol extraction part B;

(3) A and B mixing are concentrated, get relative density 1.05-1.20/55-60 ℃ fluid extract, spray drying gets intermediate products dried cream powder C;

(4) get C and appropriate amount of auxiliary materials (by the adjuvant of state-promulgated pharmacopoeia regulation) mixing, granulate, tabletting, packing gets finished tablet.

Embodiment seven:

(1) get Fructus Crataegi 10 gram, Herba Lophatheri 10 grams, Semen Cassiae 12.5 grams, Rhizoma Alismatis 17.5 grams, mix and pulverize, cross 80 mesh sieves, add clear water and boiled 10-30 minute, filter, boil again, totally twice, preserve filtrate A;

(2) with the alcohol reflux twice of filtering residue with volume by volume concentration 55-70%, each 2-3 hour, extracting solution reclaimed ethanol and gets alcohol extraction part B;

(3) A and B mixing are concentrated, get relative density 1.05-1.20/55-60 ℃ fluid extract, spray drying gets intermediate products dried cream powder C;

(4) get C and appropriate amount of auxiliary materials (by the adjuvant of state-promulgated pharmacopoeia regulation) mixing, encapsulated, get hundred million yuan of blood fat reducing capsules of finished product.

Embodiment eight:

(1) get Fructus Crataegi 18 gram, Herba Lophatheri 18 grams, Semen Cassiae 18 grams, Rhizoma Alismatis 18 grams, mix and pulverize, cross 80 mesh sieves, add clear water and boiled 10-30 minute, filter, boil again, totally twice, preserve filtrate A;

(2) with the alcohol reflux twice of filtering residue with volume by volume concentration 55-70%, each 2-3 hour, extracting solution reclaimed ethanol and gets alcohol extraction part B;

(3) A and B mixing are concentrated, get relative density 1.05-1.20/55-60 ℃ fluid extract, spray drying gets intermediate products dried cream powder C;

(4) get C and appropriate amount of auxiliary materials (by the adjuvant of state-promulgated pharmacopoeia regulation) mixing, encapsulated, get hundred million yuan of blood fat reducing capsules of finished product.

Embodiment nine:

(1) get Fructus Crataegi 18 gram, Herba Lophatheri 13 grams, Semen Cassiae 21.5 grams, Rhizoma Alismatis 30.5 grams, mix and pulverize, cross 80 mesh sieves, add clear water and boiled 10-30 minute, filter, boil again, totally twice, preserve filtrate A;

(2) with the alcohol reflux twice of filtering residue with volume by volume concentration 55-70%, each 2-3 hour, extracting solution reclaimed ethanol and gets alcohol extraction part B;

(3) A and B mixing are concentrated, get relative density 1.05-1.20/55-60 ℃ fluid extract, spray drying gets intermediate products dried cream powder C;

(4) get dried cream powder C, add an amount of syrup or Mel mixing, make pill, sterilization gets hundred million yuan of blood fat reducing balls of finished product.

Below be clinical research report of the present invention:

Blood fat reducing of the present invention and cholesterol health preparation entrust certain city-level hospital to carry out clinical verification:

Clinical data:

One, physical data,

Job step and experimental result are as follows:

Coronary disease with angina pectoris 70 examples all are higher than normal value through blood check blood fat.Wherein 40 examples are organized in treatment, male's 25 examples, and women's 15 examples, age 48--70 one full year of life,, 62.16 ± 7.33 years old mean age (X ± SD).Matched group 30 examples, male's 20 examples, women's 10 examples, age 45---70 year, average 59.31 ± 7.96 years old.Two groups of sexes, age distribution all do not have significant difference (P＞0.05).

Be and have thoracic obstruction main symptom; Chinese medical discrimination belongs to syndrome of blood stasis due to qi deficiency, and Western medicine diagnose meets the angina pectoris standard, and patient more than 2 times shows effect weekly.Wherein 40 examples are organized in treatment, male's 25 examples, and women's 15 examples, the age is in 40---70 year, average 63.39 ± 6.73 years old (X ± SO).Matched group 30 examples, male's 16 examples, women's 14 examples, age 40-70 year, average 58.734-8.84 year (X ± SD).Two groups of sexes, age distribution all do not have significant difference (P＞0.05).

Two, diagnostic criteria

1, coronary heart disease:

(1) primary symptom: the apoplexy phenomenon is arranged, the hemiplegia that has, numbness.

(2) Acute onset.

(3) crooked mouth and tongue, mind unconsciousness, stiff tongue and retardation in speech or in silence, hemianesthesia.

(3) sick sending out has inducement more, and premonitory symptom is often arranged before not sending out.

(4) how send out the age well more than 40 years old.

The selection coronary disease with angina pectoris is the object of observation.

Deficiency of vital energy blood match pattern of syndrome standard is, hemianesthesia, and pale complexion, shortness of breath and fatigue, mouthful sialorrhea is perspired, dimly pale tongue, thin white fur of tongue or white greasy, deep-thready pulse, slow or thin string carefully.

Wind-phlegm blood stasis, numbness resistance venation pattern of syndrome standard is: hemianesthesia, have a dizzy spell dimly pale tongue, thin white fur of tongue or white greasy.

2. the thoracic obstruction:

(1) chest is gloomy, very then chest pain radiating to the back.

(2) the lighter only becomes chest distress, hypopnea.

(3) Electrocardioscopy has the ischemic change or the exercise test positive.

Select in the thoracic obstruction deficiency of vital energy blood to examine the card patient and be the object of observation.Its pattern of syndrome standard is: feeling of oppression and pain in the chest, breathe hard, cardiopalmus, dizzy, dark tongue quality or ecchymosis is arranged, deep and stringy pulse or heavy thin.

Observational technique

Observe 70 examples altogether, be divided into 2 groups at random.Thoracic obstruction patient treatment group 40 examples, matched group 20 examples.The treatment group each 2, every day 3 times, serve on for 4 weeks with medicine of the present invention " hundred million yuan of blood fat reducing capsules ".Matched group is with Ginkgo oral liquid (productions of the XX of Hebei province city pharmaceutical factory), and each 10ml serve on for 4 weeks every day 3 times, and routine is made detailed physical examination to the patient before the test, with relevant physico-chemical examination, as electrocardiogram, blood fat, hemorheology, waist wear, CT scan etc.Change of illness state is kept a close eye in the test back, makes pathography weekly 1 time, as finding that the state of an illness obviously worsens, should stop test immediately and take other integrative therapy measures, and therapeutic effect is evaluated with scoring method.The curative effect judgement is directly made by the observer.Viewing duration is withdrawn the Chinese and western drugs that influences the coronary heart disease curative effect in principle.Heavier to the state of an illness, withdraw the other drug person of having any problem, can be with the Western medicine application limitations at citicoline (paralytic) and nitroglycerin (thoracic obstruction patient), other Chinese medicines and Chinese patent medicine are withdrawn without exception.Finish the relevant physico-chemical examination of back check the course of treatment.

Three, therapeutic outcome:

1. to the influence of various symptoms, sign: observe behind two kinds of treatment for diseases groups and the matched group patient treatment the various witness integrations equal highly significant that descends, illustrate that two kinds of medicines all have therapeutical effect to the apoplexy and the thoracic obstruction, treatment back paralytic's mind, language are blind, the motor function and the thoracic obstruction are patient's feeling of oppression and pain in the chest, and symptoms such as shortness of breath and palpitation, sign all have clear improvement.

2, two kinds of medicines compare onset time thoracic obstruction patient: treatment group paralytic is that (X ± SD), obviously faster than matched group (30.5 ± 1.29 week), two groups of differences have significance (P＜0,05) to 2.SS+0.99 onset time.Treatment group thoracic obstruction person is that 2.61 ± 1.13 weeks, (X ± SD) was slower than matched group (2.48 ± 1.21, two groups of difference and significance (P＞0.05) slightly onset time.

Before and after the thoracic obstruction patient physico-chemical examination treatment relatively, two groups of patient treatment after-contraction pressures, diastolic pressure, ch and TG all have obvious decline (P＜0,05), and HDL increases nonsignificance (P＞0,05), treatment group hemorheology improves obviously (P＜0,01).

4. treatment group and matched group curative effect are relatively, 70 examples are organized in paralytic's treatment, total effective rate is 89%, matched group 30 examples, and total effective rate is 76.7%, treatment group curative effect obviously is better than matched group (P＜0,01), thoracic obstruction patient treatment group 30 examples, its heart strand carbuncle curative effect, ECG curative effect, clinical card marquis curative effect total effective rate are respectively 90,0%, 60.0%, 83,4%.Matched group 30 examples, very main angor curative effect, Jb electrograph curative effect, clinical card marquis curative effect total effective rate is respectively 93.3%, 63.3%, 93,3%, two groups of relatively more equal nonsignificances (P＞0,05) of curative effect.

Two groups of patients all do not find obvious adverse reaction and toxic and side effects at viewing duration.

Model case

Example 1, Liu XX, man, 62 years old.

Because have sudden faint companion speech unfavorable, the left limb moving obstacle is admitted to hospital in emergency treatment on February 6 in 2004 half a day.Conscious having a dizzy spell, palpitation and night sweat, hemianesthesia.Inspection is seen: refreshing clear, crooked mouth and tongue sialorrhea, and language performance is owed entirely, lifts on the left shoulder joint and can not put down shoulder, and articulations digitorum manus only can be clenched fist, and left side leftover bits and pieces hip joint still can stretch in the wrong but a little less than the power, toe joint is stretched Qu Buquan, dark tongue quality, white and greasy fur, deep-thready pulse.Diagnose through CT examination: right side temporal lobe cerebral infarction, tcm diagnosis: apoplexy (apoplex involving the channels and collaterals-wind-phlegm blood stasis type).With hundred million yuan of blood fat reducing capsule for treating of the present invention, every day three times, each 6.Take medicine only two weeks, hemiplegia, having a dizzy spell begins to alleviate, and shoulder joint has gone up lifts flat shoulder, and life can partial self-help.After 30 days, former symptom disappears substantially, and patient's life can be taken care of oneself, continues to take hundred million yuan of blood fat reducing capsules, and June 9, recovery from illness was left hospital.

Example 2, Wei XX, woman, 48 years old.

The patient is admitted to hospital on November 3rd, 2003 because of " pain uncomfortable in chest, hypopnea 1 hour ", conscious pain uncomfortable in chest, shortness of breath and fatigue, cardiopalmus, has a dizzy spell.Inspection sees that lustreless complexion, asthenia lazyness are blind, dark tongue quality has speckle, white and thin fur, deep-thready pulse.Electrocardioscopy is shown: T1V3-6 is low flat, tcm diagnosis; Thoracic obstruction Qi deficiency blood stasis type, Western medicine diagnose: angina pectoris.With hundred million yuan of blood fat reducing capsule for treating of the present invention, day obeying each 63 times.After, sensation of oppression over the chest with shortness of breath, the weak beginning of cardiopalmus alleviate, and are kept to 1 time for 2 times the every day of feeling of oppression and pain in the chest when being admitted to hospital, time, pain degree obviously alleviated by being kept to 10 minutes half an hour, around the after, pain uncomfortable in chest is not reaccessed, only surplus slightly breathing hard and dizzy symptom, and surplus disease disappears.Check electrocardiogram: normal ECG roughly.Curative effect to treat angina pectoris, ECG curative effect and clinical card marquis efficacy evaluation are produce effects.

Conclusion:

Above clinical data discloses:

1. blood fat reducing of the present invention and cholesterol health preparation have the promote blood circulation effect of brain-strengthening suppressing the hyperactive liver of inrigorating qi and promoting blood circulation, dispelling pathogenic wind and eliminating phlegm, blood stasis dispelling, and cerebral infarction card, angina pectoris due to blood stasis due to qi deficiency, wind-phlegm blood stasis, the passages through which vital energy circulates impatency are had therapeutical effect.

2, blood fat reducing of the present invention and cholesterol health preparation have blood pressure lowering, effect for reducing blood fat, and hemorheology is also improved significantly, and prompting offsets except that symptom before the apoplexy, and reducing cerebrovascular disease has certain preventive and therapeutic effect.

3. blood fat reducing of the present invention and cholesterol health preparation treatment paralytic 70 examples, total effective rate is 89%, curative effect is better than the Ginkgo oral liquid that XX city, Hebei province pharmaceutical factory produces.The treatment thoracic obstruction 30 examples, the total effective rate of angina pectoris, electrocardiogram, symptom curative effect is for being respectively 90.0%, 60.0%, 83,4%, curative effect and ginkgo oral liquid no significant difference.

4. this product is safe and reliable, and 130 examples are not all found obvious adverse reaction and toxic and side effects at viewing duration

The embodiment of blood fat reducing of the present invention and cholesterol health preparation treatment hyperlipidemia and hypercholesterolemia:

Tang * *, the woman, nineteen sixty-eight gives birth to, Nanning people from city is because of suffering from hyperlipidemia, concurrent hypertension, coronary heart disease, often dizzy, asthma upstairs, at the beginning of 2003 in certain hospitalize, take the Western medicine lovastatin, but symptom makes moderate progress, but the symptom commentaries on classics of not getting better after the drug withdrawal, after change and take " hundred million yuan of blood fat reducing capsules ", every 0.5 gram, every day 3 times, each 6, and take hundred million primordial oral liquids, 2 of every days, 10 milliliters every, take that frequent dizzy symptom takes a turn for the better after 20 days, take one month after, symptom all disappears, spirit takes a turn for the better, muscle power increases, and is of pink and healthy-looking, feels good.

The land * *, man, life in 1949, haunt and plague left people from city in Guangxi, on June 10th, 2003 was suffered from coronary heart disease at examination in hospital, often angina pectoris, dyspnea owing to lack of capital and be not in hospital, is taken " hundred million yuan of blood fat reducing sheets " every day 3-4 time, totally 30, every 0.3 gram, and take hundred million primordial oral liquids, 2 of every days, 10 milliliters every, take two all aftersensation and get that sb.'s illness took a favorable turn, breathe smooth and easyly, present anginal symptom takes a turn for the better.

Yellow * *, woman, life in 1956, Baise of Guangxi people from city, numb limbs and tense tendons, distortion of commissure, sialorrhea, slurred speech, crank uneasiness.Take " hundred million yuan of blood fat reducing capsules " in October, 2003 after 20 days, numb limbs and tense tendons alleviates, artistomia, take 5 months after, walking is convenient, thing can do housework.

Open * *, the man, nineteen fifty gives birth to, Baise of Guangxi people from city.Autumn in 2003, the household catch sight of open * * go home very late, the vestige of falling and falling is arranged on the clothes trousers, but the household is when asking that he is why, he says nothing, just says and does not know, can not remember, and is very unclear in a minute.Sending inspection to hospital through the household just knows because cerebral arteriosclerosis causes cerebral thrombosis, brain atrophy, brain dementia.Take " hundred million yuan of blood fat reducing capsules " in November, 2003 after one month, it is more steady to walk, and keeps one's legs, and it is strong that extremity are felt, it is clearer to speak, some recovery of memory, and after half a year, disease disappears substantially to take " hundred million yuan of blood fat reducing capsules ".

The king * *, the man, nineteen fifty-two gives birth to, the worker that retires due to illness of Nanning city unit.Because of suffering from brain bolt disease for many years, numb limbs and tense tendons be can't take care of oneself, inarticulateness, and temper is dry, pessimism.Begin to take " hundred million yuan of blood fat reducing capsules " every day three times in March, 2004, each five, behind the first quarter moon, extremity begin that consciousness is arranged, and it is conscious strong to hold object, and mood is also felt better, take 6 months continuously after, can walk, live and can take care of oneself, articulate, speak with fluency.

High * *, the man, nineteen fifty-five gives birth to, the laid-off worker of Liuzhou city unit catches sight of myasthenia of limbs in August, 2003, a species of orchid circle when walking, the difficulty of drinking water, on inspection, there is infraction in the brain stem district, because of financial difficulties can not be in hospital for a long time, in December, 2003 is taken " hundred million yuan of blood fat reducing capsules " every day three times, and each 4, behind the first quarter moon, the sensation extremity are strong, and it is more stable to walk, and it is smooth and easy to drink water, mood is also happy, take half a year after, disease symptoms is eliminated.

Claims (8)

1, the health preparation of a kind of blood fat reducing and cholesterol is characterized in that: said preparation is to be made by the raw material of Chinese medicine of following mass fraction:

Fructus Crataegi 10-20; Herba Lophatheri 10-20; Semen Cassiae 12.5-25; Rhizoma Alismatis 17.5-35.

2, the health preparation of a kind of blood fat reducing as claimed in claim 1 and cholesterol is characterized in that: said preparation is any dosage form on the pharmaceutics.

3, the preparation method of the health preparation of a kind of blood fat reducing as claimed in claim 1 and cholesterol is characterized in that producing by the following method capsule:

(1) get Fructus Crataegi, Herba Lophatheri, Semen Cassiae, Rhizoma Alismatis, mixing and pulverize, cross 80 mesh sieves, add clear water and boiled 10-30 minute, filter, boil again, totally twice, preserve filtrate A;

(2) with the alcohol reflux twice of filtering residue with volume by volume concentration 55-70%, each 2-3 hour, extracting solution reclaimed ethanol and gets alcohol extraction part B;

(3) A and B mixing are concentrated, get relative density 1.05-1.20/55-60 ℃ fluid extract, spray drying gets intermediate products dried cream powder C;

(4) get C and appropriate amount of auxiliary materials mixing, granulate, encapsulated dress gets the finished capsule product agent.

4, the preparation method of the health preparation of a kind of blood fat reducing as claimed in claim 1 and cholesterol is characterized in that producing by the following method tablet:

(1) get Fructus Crataegi, Herba Lophatheri, Semen Cassiae, Rhizoma Alismatis, mixing and pulverize, cross 80 mesh sieves, add clear water and boiled 10-30 minute, filter, boil again, totally twice, preserve filtrate A;

(2) with the alcohol reflux twice of filtering residue with volume by volume concentration 55-70%, each 2-3 hour, extracting solution reclaimed ethanol and gets alcohol extraction part B;

(3) A and B mixing are concentrated, get relative density 1.05-1.20/55-60 ℃ fluid extract, spray drying gets intermediate products dried cream powder C;

(4) get C and appropriate amount of auxiliary materials (by the adjuvant of state-promulgated pharmacopoeia regulation) mixing, granulate, tabletting, packing gets finished tablet.

5, the preparation method of the health preparation of a kind of blood fat reducing as claimed in claim 1 and cholesterol is characterized in that producing by the following method granule:

(1) get Fructus Crataegi, Herba Lophatheri, Semen Cassiae, Rhizoma Alismatis, mixing and pulverize, cross 80 mesh sieves, add clear water and boiled 10-30 minute, filter, boil again, totally twice, preserve filtrate A;

(2) with the alcohol reflux twice of filtering residue with volume by volume concentration 55-70%, each 2-3 hour, extracting solution reclaimed ethanol and gets alcohol extraction part B;

(3) A and B mixing are concentrated, get relative density 1.05-1.20/55-60 ℃ fluid extract, spray drying gets intermediate products dried cream powder C;

(4) get C and appropriate amount of auxiliary materials (by the adjuvant of state-promulgated pharmacopoeia regulation) mixing, granulate, drying, packing gets the finished particle agent.

6, the preparation method of the health preparation of a kind of blood fat reducing as claimed in claim 1 and cholesterol is characterized in that producing by the following method teabag:

Get Fructus Crataegi, Herba Lophatheri, Semen Cassiae, Rhizoma Alismatis kind Chinese medicine mix homogeneously, pulverized 80 mesh sieves, add 5 times of tea packagings; Perhaps add Folium Ginkgo, pulverize, packing is made teabag.

7, the preparation method of the health preparation of a kind of blood fat reducing as claimed in claim 1 and cholesterol is characterized in that producing by the following method pill:

(1) get Fructus Crataegi, Herba Lophatheri, Semen Cassiae, Rhizoma Alismatis, mixing and pulverize, cross 80 mesh sieves, add clear water and boiled 10-30 minute, filter, boil again, totally twice, preserve filtrate A;

With the alcohol reflux twice of filtering residue with volume by volume concentration 55-70%, each 2-3 hour, extracting solution reclaimed ethanol and gets alcohol extraction part B;

(3) A and B mixing are concentrated, get relative density 1.05-1.20/55-60 ℃ fluid extract, spray drying gets intermediate products dried cream powder C;

(4) get C and Mel and auxiliary materials and mixing, stir, make pill, and make it dry, coating promptly obtains product.

8, the preparation method of the health preparation of a kind of blood fat reducing as claimed in claim 1 and cholesterol is characterized in that producing by the following method oral liquid:

(1) get whole Fructus Crataegis, Herba Lophatheri, Semen Cassiae, Rhizoma Alismatis mixing pulverizing, with the alcohol reflux twice of volume by volume concentration 55-70%, each 2-3 hour, extracting solution reclaimed ethanol and gets the alcohol extraction part A;

(2) medicinal residues after the above-mentioned alcohol extraction and Fructus Crataegi, Herba Lophatheri, Semen Cassiae, Rhizoma Alismatis are added 5-8 times of water gaging decoction twice, each 2-3 hour, get water and carry part B;

(3) A and B mixing are concentrated, get relative density 1.05-1.20/55-60 ℃ fluid extract, add an amount of syrup or Mel mixing, sterilization gets the finished product oral liquid.