CN1660068A - Application of ethoxy ethyl ester alpha-cyanoacrylate in preparing adhesive of medical use for treating hernia and binding skin tissue - Google Patents
Application of ethoxy ethyl ester alpha-cyanoacrylate in preparing adhesive of medical use for treating hernia and binding skin tissue Download PDFInfo
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- CN1660068A CN1660068A CN 200510005164 CN200510005164A CN1660068A CN 1660068 A CN1660068 A CN 1660068A CN 200510005164 CN200510005164 CN 200510005164 CN 200510005164 A CN200510005164 A CN 200510005164A CN 1660068 A CN1660068 A CN 1660068A
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- cyanoacrylate
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- ethoxy ethyl
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Abstract
An application of alpha-ethoxyethyl cyanoacrylate in preparing the medical adhesive for treating hernia, adhering skin tissue and repairing human internal organs is disclosed.
Description
Technical field
The present invention relates to a kind of adherent adhesive of medical of tissue (medical glue) that is used for, the medical application that particularly a kind of existing chemical materials uses as adhesive of medical in human body viscera device repairing and treating and skin histology are bonding.
Background technology
The a-cyanoacrylate class (molecular structural formula:
) stronger adhesion strength is arranged, originally purposes all is industrial the bonding of various materials that be used for.After nineteen seventies, report that abroad useful α-Qing Jibingxisuanzhengdingzhi is used for the sterilization operations such as stifled of gluing of women's fallopian tube and male's vas deferens in men and women's sterillization.The late nineteen eighties α-Qing Jibingxisuanzhengxinzhi begin use, the bonding and viscus hemostasis that isobutyl alpha-cyanoacrylate is used for all kinds of traumatic wounds has appearred again in the nineties, existing production firm has Beijing to like joy and the medical glue of wink health company etc.
The a-cyanoacrylate class is used to prepare the binding agent for the treatment of hernia to be used, and has Beijing to like the α-Qing Jibingxisuanzhengxinzhi of the medical glue of joy company production and the isobutyl alpha-cyanoacrylate that the medical glue of wink health company produces at present.In the bonding application of internal organs, all have the strong and albinism serious problems of zest, promptly strong to tissue stimulation, between viscera tissue, easily produce scleroma.Therefore, seek a kind of more ideal adhesive of medical is the target that people pursue always.
Summary of the invention
The object of the invention provides the new purposes of ethoxy ethyl ester alpha-cyanoacrylate, promptly in the new purposes aspect adhesive of medical (medical glue).What in fact, the present invention relates to is the application of ethoxy ethyl ester alpha-cyanoacrylate in the adhesive of medical of preparation treatment hernia.
The object of the invention also is to relate to the application of ethoxy ethyl ester alpha-cyanoacrylate in the adhesive of medical of preparation binding skin tissue.
In order further to understand the present invention, below with ethoxy ethyl ester alpha-cyanoacrylate in the adhesive of medical of preparation treatment hernia the applied research process details are as follows.
One. ethoxy ethyl ester alpha-cyanoacrylate, structural formula:
Its method for making is all α-cyanoacetic acid ethoxy ethyl ester and formaldehyde condensation reflection, adds polymerization inhibitor, plasticizer, stabilizing agent again, cracking then, refining forming.Its performance only plays the effect of temporary adhesion bridge joint in the treating hernia process, then degraded and absorbed can not make foreign body be present in the tissue; Polymer between the tissue that leaves after the treatment has identical toughness with tissue, and local irritation is lighter, and bonding force is the strongest.
Two. the purposes of several medical glue, composition and performance are relatively
1. α-Qing Jibingxisuanzhengxinzhi likes that by Beijing the medical glue of joy company produces.
2. isobutyl alpha-cyanoacrylate is produced by Beijing medical glue of wink health company.
Structural formula:
3. ethoxy ethyl ester alpha-cyanoacrylate is existing by the chemical industry manufacturer production.
Structural formula:
More than three kinds of medical collagens come purposes all to be used for industrial iron and steel, elastomeric material is bonding.But wherein α-Qing Jibingxisuanzhengxinzhi and isobutyl alpha-cyanoacrylate now all can be used for the hemostasis of internal organs such as the bonding of tissue and liver spleen, do not have ethoxy ethyl ester alpha-cyanoacrylate to be used for the bonding or adherent medical application report of skin histology of hernia so far.
More than the total characteristics of three kinds of medical glue be, all nontoxic, do not have irritated, side effect such as no carcinogenic grade.
Pulling force contrast: α-Qing Jibingxisuanzhengxinzhi＜isobutyl alpha-cyanoacrylate＜ethoxy ethyl ester alpha-cyanoacrylate.
The hardness contrast of polymer in tissue: ethoxy ethyl ester alpha-cyanoacrylate＜α-Qing Jibingxisuanzhengxinzhi＜isobutyl alpha-cyanoacrylate.
So preparation treatment hernia and be used for the adherent medical glue of skin histology should first-selected ethoxy ethyl ester alpha-cyanoacrylate, because of its bonding force is the strongest, and the toughness of polymer that forms and tissue is the most approaching.
Three. be used for the selection of the a-cyanoacrylate class binding agent for the treatment of hernia
The Clinics and Practices method of hernia: hernia (abdominal external hernia) be in the abdomen internal organs or tissue through the weak spot of stomach wall or tub wall or damaged to the outstanding lump that forms of body surface.Common indirect inguinal hernia be in the abdomen internal organs by the internal ring of inguinal canal, the hernia of deviating from along the inguinal canal diagonal and from its outer shroud.At present Therapeutic Method gives the high ligation hernical sac for the surgical incision stomach wall after finding hernical sac, repairs stomach wall and inguinal weakness then, makes that hernical sac is unlikely to be deviate from again.The mode that adopts injection with medical glue is with hernical sac and the hernia pipe is bonding can reach therapeutic effect equally, must possess at the medical glue of this requirement: 1. because tension force die bonding strength should be big; 2. because long-term implant into body is interior so polymer should have the toughness approaching with tissue.
Selection test to various medical glue: according to overtension in the hernia repair, and require polymeric toughness to approach normal human tissue, so should select for use adhesion strength (pulling force) big, polymer toughness approaches the medical glue of human normal tissue.For this reason, the present invention selects for use ethoxy ethyl ester alpha-cyanoacrylate to do experiment, and the result has obtained than the more satisfied effect of existing medical glue.
Four. ethoxy ethyl ester alpha-cyanoacrylate is used for preparation treatment hernia adhesive application result of the test.
The inventor has studied ethoxy ethyl ester alpha-cyanoacrylate theoretically and has been used for the feasibility that the treating hernia binding agent uses since 1998.Begin to found that at the ethoxy ethyl ester alpha-cyanoacrylate of skin undertissue many places injection on one's body there is very slight excitement the part the basic disappearance of local later on scleroma in March, 1999 by one month.Begin ethoxy ethyl ester alpha-cyanoacrylate is used for the clinical treatment inguinal hernia in November, 1999, and effect is very good, solved the patient and treated the abnormal sensory that scleroma is left in the part, back in the past.
The specific embodiment
Embodiment and and existing medical glue contrast
1) ethoxy ethyl ester alpha-cyanoacrylate treatment case.Zhang Wenze, 51 years old, people from Gaoyi County, Hebei province, in December, 1999 is gone to a doctor, and is diagnosed as indirect inguinal hernia (right side), and is all right through with ethoxy ethyl ester alpha-cyanoacrylate injection further consultation after month, the obviously scleroma of local nothing, the patient does not have any discomfort sense.
2) α-Qing Jibingxisuanzhengxinzhi treatment case.Li Qiang, 30 years old, people from Woyang County, Anhui Province, go to a doctor in January, 2000, be diagnosed as indirect inguinal hernia (right side), inject further consultation after two months with α-Qing Jibingxisuanzhengxinzhi, there is a scleroma part, further consultation after three months still have a soft slightly scleroma, and the part has sense of discomfort slightly.
3) isobutyl alpha-cyanoacrylate treatment case.The Wang, 50 years old, people from Woyang County, Anhui Province, go to a doctor in January, 2000, is diagnosed as indirect inguinal hernia (right side), injects further consultation in back two months with isobutyl alpha-cyanoacrylate, and there is a scleroma part; Further consultation after six months, part have scleroma slightly, and the part has sense of discomfort slightly.
Ethoxy ethyl ester alpha-cyanoacrylate is used for the treatment of the using method of hernia as medical glue: routine disinfection, local anesthesia, with 10ml syringe 12# syringe needle, forefinger inserts the guidance of hernia pipe outer shroud down by scrotum leftward, the right hand is held syringe 1.5cm from the finger tip and is vertically thrust the hernia pipe, after the sense that falls through is arranged, aspirate no blood back, left hand food, middle finger are pushed down internal ring, and thumb is pushed down outer shroud, rapidly medical glue are injected, take out syringe needle, push hernia pipe position after 5 minutes, reuse is injected with method, till collar extension can be held finger tip outside touching.
The application of ethoxy ethyl ester alpha-cyanoacrylate in surgery
Example: patient, the man, 40 years old, cut the otch of a 1.8cm in March, 98 because of carelessness with kitchen knife, come to go to a doctor, application process: normal skin and otch wound surface are thoroughly stopped blooding, edge clean is wiped away dried, with tweezers or finger that otch skin edge is involutory closely, the edge is irregular with involutory again after the shears trimmed, then ethoxy ethyl ester alpha-cyanoacrylate is sucked in the plastic jar of sterile band elongate tip in the little peace bottle of glass, light extruding plastic bottle, liquid ethoxy ethyl ester alpha-cyanoacrylate glue evenly is applied to otch skin (not being applied between otch), with finger that skin edge is involutory, keep after the several seconds promptly bonding.The result: it is bonding to use above-mentioned medical glue to solidify in second at 4-8, and Pi Yuan is involutory good, has saved the operation stitching time, and healing in seven days is good, does not have really and need take out stitches, and reduces the advantage of wound surface cicatrix.
Claims (2)
1. the application of ethoxy ethyl ester alpha-cyanoacrylate in the adhesive of medical of preparation treatment hernia.
2. the application of ethoxy ethyl ester alpha-cyanoacrylate in the adhesive of medical of preparation binding skin tissue.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200510005164 CN1660068A (en) | 2005-02-01 | 2005-02-01 | Application of ethoxy ethyl ester alpha-cyanoacrylate in preparing adhesive of medical use for treating hernia and binding skin tissue |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200510005164 CN1660068A (en) | 2005-02-01 | 2005-02-01 | Application of ethoxy ethyl ester alpha-cyanoacrylate in preparing adhesive of medical use for treating hernia and binding skin tissue |
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| CN1660068A true CN1660068A (en) | 2005-08-31 |
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| CN 200510005164 Pending CN1660068A (en) | 2005-02-01 | 2005-02-01 | Application of ethoxy ethyl ester alpha-cyanoacrylate in preparing adhesive of medical use for treating hernia and binding skin tissue |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8864741B2 (en) | 2008-05-19 | 2014-10-21 | Jean-Pierre Lilley | Varicose vein treatment |
| CN104399113A (en) * | 2014-11-25 | 2015-03-11 | 苏州市贝克生物科技有限公司 | Adhesive for soft tissues and preparation method of adhesive |
| US9132194B2 (en) | 2011-07-12 | 2015-09-15 | Warsaw Orthopedic, Inc. | Medical devices and methods comprising an adhesive sheet containing a drug depot |
| US9205241B2 (en) | 2011-07-12 | 2015-12-08 | Warsaw Orthopedic, Inc. | Medical devices and methods comprising an adhesive material |
-
2005
- 2005-02-01 CN CN 200510005164 patent/CN1660068A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8864741B2 (en) | 2008-05-19 | 2014-10-21 | Jean-Pierre Lilley | Varicose vein treatment |
| US9132194B2 (en) | 2011-07-12 | 2015-09-15 | Warsaw Orthopedic, Inc. | Medical devices and methods comprising an adhesive sheet containing a drug depot |
| US9205241B2 (en) | 2011-07-12 | 2015-12-08 | Warsaw Orthopedic, Inc. | Medical devices and methods comprising an adhesive material |
| US9504749B2 (en) | 2011-07-12 | 2016-11-29 | Warsaw Orthopedic, Inc. | Medical devices and methods comprising an adhesive sheet containing a drug depot |
| CN104399113A (en) * | 2014-11-25 | 2015-03-11 | 苏州市贝克生物科技有限公司 | Adhesive for soft tissues and preparation method of adhesive |
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