CN1521499A - Multidirectional logic type micro-fluid control system and method thereof - Google Patents
Multidirectional logic type micro-fluid control system and method thereof Download PDFInfo
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- CN1521499A CN1521499A CNA031025552A CN03102555A CN1521499A CN 1521499 A CN1521499 A CN 1521499A CN A031025552 A CNA031025552 A CN A031025552A CN 03102555 A CN03102555 A CN 03102555A CN 1521499 A CN1521499 A CN 1521499A
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Abstract
The invention relates to a multidirectional logic type micro-fluid control system and a method thereof, which determine the flow direction and the mixing number of fluid by controlling whether the micro-pipeline fluid connected with a micro-fluid component passes or not; the micro-pipes which are connected in the plurality of micro-pipes of the fluid assembly and have the preset flow direction of the fluid allow the fluid to pass through, and the micro-pipes which are not in the preset flow direction of the fluid do not allow the fluid to pass through, so that the fluid flows towards the preset flow direction of the fluid; the system formed by matching the method of the invention can also be combined with a controller to load programs to carry out more complicated fluid movement.
Description
Technical field
The present invention relates to a kind of fluid control systems and method thereof, particularly a kind of multi-direction logical formula microfluidic control system and method thereof.
Background technology
Analyze micro-total analysis system (the Micro Total Analysis Systems of detection method along with being widely used in combined chemical, genosome and proteosome technology etc., the development of μ-TAS) is day by day flourishing, and analytical instrument and system have also entered new era of micron even nanometer scale.Micro-total analysis system is that the biochemical or general chemical reaction that will carry out in the experiment is incorporated on the small chip, for example a large amount of biochemical substances fragment one ends is fixed in chip surface, and makes a material fragment and a various corpse or other object for laboratory examination and chemical testing produce reciprocation between the two by similar mode.
Need some fluid manipulation steps and carry out this experiment, make micro-total analysis system can bring into play its effect, allow material in the middle of the chip with to enter a corpse or other object for laboratory examination and chemical testing in the middle of the chip fully mixed and react.And do not having liquid handling device or similarly be difficult to make fluid to mix and the robotization of flowing under the flow mixing device.So being solution fluid treatment problem, some microfluid drives arise at the historic moment.Yet present employed microfluid drive mostly is unidirectional or two-way flow, no matter be mechanical micro-pump (Mechanicmicropumps) and on-mechanical formula micropump (non-mechanic micropumps).The fluid control of lack of wisdom type.When being used in comparatively complicated biochemical reaction and check and analysis, often be difficult to once finish the mixing of the required fluid of control and the step of reaction.
Therefore, under the demand that science and technology detects for micro-total analysis system now, the chip that can carry out complexity and robotization detection becomes one of important development direction.As disclosed a kind of " Microfluid control system for micromachines " technology in the collection of thesis " Flucome2000 " (international book sign indicating number ISBN2-7622-0126-8) of Canada's in August, 2000 Flucome meeting.Therefore, can't satisfy in the existing pump technology under the situation of demand like this, be necessary to design other easy fluid control method think in response to.
Summary of the invention
Technical matters to be solved by this invention reaches effective control microfluidic flow direction and the purpose of mixing for a kind of multi-direction logical formula microfluidic control system and method thereof are provided.
For reaching above-mentioned purpose, the invention provides a kind of multi-direction logical formula microfluidic controller that comprises, formed by a substrate and a plurality of microfluidic control point, wherein, fluid is filled in the middle of the microchannel of substrate.More specifically substrate (Substrate) design of the present invention, have a microfluid component and many microchannels, microchannel and microfluid component form same plane, and be connected its microfluid component, each microchannel correspondence is equipped with microfluidic control point, whether passes through in order to the fluid of controlling microchannel.
By the simple design of this kind, the present invention can control and drive the central fluid of substrate microchannel by simple effective method, even be connected in a plurality of microchannels of fluid assembly, the microchannel of fluid predetermined flow direction allows fluid to pass through, the microchannel of nonfluid predetermined flow direction does not allow fluid pass through, and fluid is flowed towards the fluid predetermined flow direction.For example, microfluid component and microchannel are formed can be for the mobile back and forth cross path of fluid.Whether the fluid that is connected in the microchannel of four in-planes by the control microfluid component passes through, and decides the flow direction of fluid.Utilize cross array characteristic,, be controlled to be and stop that fluid passes through, then and then fluid is flowed towards remaining direction the microfluidic control point in the tripartite microchannel among four in-plane microchannels of fluid assembly.
In addition, the present invention also provides a kind of multi-direction logical formula microfluidic control system of digit group type, by the multi-direction logical formula microfluidic controller of the many groups of design on substrate, interconnect by microchannel between each microfluid component, to form multiple spot, multi-direction logical formula microfluidic control system.So, can in different microfluid components, inject different fluids, and can make it toward the microfluid component direction is mobile arbitrarily.At last, also other fluid can be mixed in arbitrarily in the middle of the shared microfluid component; Or increase the microchannel number that is connected in microfluid component, the above fluid in four roads is mixed.(programmable logic controllers PLCs) controls the microfluidic control point of each microchannel, can carry out the fluid motion of complicated pluralism more as cooperating digital signal processing processor (DSP) or Programmable Logic Controller again.
Description of drawings
Fig. 1 is the multi-direction logical formula microfluidic controller synoptic diagram of first embodiment of the invention; And
Fig. 2 is the multi-direction logical formula microfluidic control system synoptic diagram of second embodiment of the invention.
Wherein, description of reference numerals is as follows: 100--substrate, 110--micro fluid reaction district, the 111--first micro fluid reaction district, the 112--second micro fluid reaction district, 113--the 3rd micro fluid reaction district, 114--the 4th micro fluid reaction district, 120--microchannel, 130-microfluid drive.
Embodiment
Multi-direction logical formula microfluidic control system disclosed in this invention and method thereof are applicable to any fluid drives mode, as piezoelectric type, electromagnetic type and thermal change formula or the like.
With the formed microfluid drive of micro-actuator is example, and with the micro fluid reaction district as the microfluid component that carries out fluid reaction.Fig. 1 is the multi-direction logical formula microfluidic controller synoptic diagram of first embodiment of the invention.Formed by a substrate 100 and four microfluid drives 130, wherein, fluid is to fill in the middle of the microchannel 120 of substrate 100.The design of substrate has a micro fluid reaction district 110 and four microchannels 120, microchannel 120 is used for connecting four in-planes in micro fluid reaction district 110, promptly be the positive and negative directions X and the positive and negative Y direction of initial point, form and to make the fluid can be by micro fluid reaction district 110 and the cross path that flows back and forth with micro fluid reaction district 110.Its microfluid drive 130 is corresponding each microchannel 120 of installing, and is made up of micro-actuator and elastic film; Elastic film is to stick in substrate to isolate microchannel and micro-actuator, and micro-actuator is then back and forth exerted pressure by elastic film and utilized similar phrenic mode to move to promote elastic film; When micro-actuator is exerted pressure to film, then make the film projection stop that fluid passes through, and micro-actuator is when loosening film, promptly since the smooth liquid that makes of elastic recovery of film itself can pass through.Whether the present invention passes through by the fluid that control micro fluid reaction district connects the microchannel of four in-planes, decides the flow direction of fluid.Utilize cross array characteristic, with the microfluid drive in the wherein tripartite microchannel of four in-plane microchannels in micro fluid reaction district, be controlled to be stop fluid by and a reverse thrust is provided, and then fluid is flowed towards remaining direction.
In addition, the present invention also provides a kind of multi-direction logical formula microfluidic control system of digit group type, and Fig. 2 is the multi-direction logical formula microfluidic control system synoptic diagram of second embodiment of the invention.Four groups of multi-direction logical formula microfluidic controllers of design on substrate have wherein comprised the first micro fluid reaction district 111, the second micro fluid reaction district 112, the 3rd micro fluid reaction district 113, the 4th micro fluid reaction district 114, have been used for interconnected microchannel 120 and be located at the microfluid drive 130 of microchannel 120.With the first micro fluid reaction district 111 is initial point, and the first micro fluid reaction district 111 is interconnected by the microchannel 120 and the second micro fluid reaction district 112 that bear directions X, and is interconnected by the microchannel 120 and the 3rd micro fluid reaction district 113 of negative Y direction; The 4th micro fluid reaction district 114 is interconnected by the microchannel 120 of positive Y direction and the second micro fluid reaction district 112, and is interconnected by the microchannel 120 and the 3rd micro fluid reaction district 113 of positive directions X.Form the multi-direction logical formula microfluidic control system of multiple spot cross digit group type.So, can in different micro fluid reaction districts, inject different fluids, and can make it toward micro fluid reaction district direction is mobile arbitrarily.For example, control is located at the microfluid drive 130 of microchannel 120, the fluid of second micro fluid reaction, 112 districts and the 3rd microfluid 113 reaction zones will be stored in, mode with 3 drivings makes fluid flow to the first micro fluid reaction district 111, can make fluid drive district 111 at first microfluid and carry out hybrid reaction.Hence one can see that, and the present invention can further be widely used in the mixing and the control of multiple tracks fluid, but and combined digital signal handle processor (DSP) and control microfluid drive, the program loading control can be carried out multiple spot control simultaneously.Or (programmable logic controllers PLCs) controls the microfluid drive of each microchannel, can carry out the fluid motion of complicated pluralism more to cooperate programmable logic controller (PLC).For cooperating with its fluid admixture of programmed control, the state that multi-direction logical formula microfluidic controller has fluid to enter can be made as high state 1, the state that no fluid enters is made as low state 0, cooperate the fluid numerical value board design of fluid in-out end, can make microfluid be subjected to the control of logical formula, simplify the complicacy that fluid is controlled.
In addition, the microfluid component design on microchannel and the substrate can be made according to various demands, and the elastic space of application is very big.Mix as the fluid that multi-direction logical formula microfluidic controller is carried out more than four roads through design, promptly set four groups of above microchannel and microfluid drivers and be connected the microfluid component that will mix, the angle between its adjacent microchannel is less than 90 degree.
The above only is preferred embodiment of the present invention, but is not to be used for limiting practical range of the present invention; Therefore the present invention's claim scope required for protection should be applied for that the claim of protecting is as the criterion with claims.
Claims (11)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CNA031025552A CN1521499A (en) | 2003-02-12 | 2003-02-12 | Multidirectional logic type micro-fluid control system and method thereof |
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| CNA031025552A CN1521499A (en) | 2003-02-12 | 2003-02-12 | Multidirectional logic type micro-fluid control system and method thereof |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102416350A (en) * | 2006-03-22 | 2012-04-18 | 加州大学评议会 | Multiplexed latching valves for microfluidic devices and processors |
| CN103616910A (en) * | 2013-12-17 | 2014-03-05 | 苏州汶颢芯片科技有限公司 | Multi-channel fluid automatic control device |
| CN110006882A (en) * | 2019-04-03 | 2019-07-12 | 山东职业学院 | A kind of micro-fluidic chip and detection method detecting Water phosphorus content |
| CN112570050A (en) * | 2019-09-27 | 2021-03-30 | 厦门大学 | Fluid transportation control system and method |
-
2003
- 2003-02-12 CN CNA031025552A patent/CN1521499A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102416350A (en) * | 2006-03-22 | 2012-04-18 | 加州大学评议会 | Multiplexed latching valves for microfluidic devices and processors |
| CN103616910A (en) * | 2013-12-17 | 2014-03-05 | 苏州汶颢芯片科技有限公司 | Multi-channel fluid automatic control device |
| CN110006882A (en) * | 2019-04-03 | 2019-07-12 | 山东职业学院 | A kind of micro-fluidic chip and detection method detecting Water phosphorus content |
| CN110006882B (en) * | 2019-04-03 | 2021-06-25 | 山东职业学院 | Micro-fluidic chip for detecting nitrogen and phosphorus content in water body and detection method |
| CN112570050A (en) * | 2019-09-27 | 2021-03-30 | 厦门大学 | Fluid transportation control system and method |
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