CN1582979A - Brain and intellectual health care medicine and its preparation - Google Patents
Brain and intellectual health care medicine and its preparation Download PDFInfo
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- CN1582979A CN1582979A CN 03140458 CN03140458A CN1582979A CN 1582979 A CN1582979 A CN 1582979A CN 03140458 CN03140458 CN 03140458 CN 03140458 A CN03140458 A CN 03140458A CN 1582979 A CN1582979 A CN 1582979A
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Abstract
A Chinese medicine for invigorating the function of brain, developing intelligence, and treating dementia and anoesia is prepared from 13 Chinese-medicinal materials including ginseng, wolfberry fruit, white fleece flower root, pig brain, etc. Its preparing process is also disclosed.
Description
Technical field
The present invention relates to a kind of nourishing the brain and improving intelligence medicine and preparation method.
Background technology
Dementia starts from " bright doctor's record " and " money is given birth to " book, " silly card " by name.Zhang Jingyue " miscellaneous diseases plan " name is said: " dull-witted card ".Clear old scholar's tongued bell " dialectical record " name is said " slow-witted card ", and miscellaneous diseases source and course rhinoceros candle name is said: " evil thing disease ".On sick position, propose: " first god does not keep ", first refreshing person's brain, so Li Shizhen (1518-1593 A.D.) is said " the brain being the house of mentality " " the brain being the reservoir of the marrow ", kidney is given birth to the marrow marrow and is given birth to brain, and promptly all marrow persons all belong to brain, and pipe is said " kidney is given birth to brain ", on etiology and pathogenesis.Clear Chen Shi " dialectical record " propose " one-tenth of dementia, must have its because of, approximately its beginning also arises from the strongly fragrant of irritability ..., the declining of gastric qi ... expectorant can not be changed strongly fragrant in breast, and dish occupies outside the breast makes bright unclearly, forms dementia ".Support and give birth to through saying " the big will of overtaxing one's nerves of being worried, refreshing deficiency is then mad silly, also because of amassing terrified impairment of QI kidney also ".Dementia, its clinical symptom are intellectual deterioration and behavior and personality changes.Its sickness rate accounts for the 4-5% of population, accounts for 50% in alzheimer disease, and multi-infarct dementia accounts for 15-20%, and all the other account for 15-20% and are called the Combination dementia.The primary disease doctor trained in Western medicine does not have specific drug, and Chinese medicine is also at the startup to this sick treatment.
Summary of the invention
First purpose of the present invention is to provide a kind of nourishing the brain and improving intelligence medicine that is used for dementia and mental retardation crowd.
Second purpose of the present invention is to provide a kind of preparation method of above-mentioned nourishing the brain and improving intelligence medicine.
First purpose of the present invention is achieved in that nourishing the brain and improving intelligence medicine of the present invention is the various medicinal preparation for oral administration of being made by following raw material:
Radix Ginseng (sun-dried) 2%-5%, Fructus Lycii 18%-22%,
Radix Polygalae (processed with honey) 4%-8%, Rhizoma Drynariae 2%-6%,
Radix Cynanchi Auriculati 8%-12%, Rhizoma Polygonati 8%-12%,
Rhizoma Acori Graminei 8%-12%, Petiolus nelumbinis 7%-11%,
Radix Curcumae 1%-5%, Fructus Perillae (stir-fry) 3%-7%,
Cornu Cervi Pantotrichum 1%-1.5%, Herba Cistanches 7%-11%,
Medulla sus domestica 7%-10%; Aforementioned each percentage composition is weight percentage.
The optimum weight percentage composition of each raw material is:
Radix Ginseng (sun-dried) 3.24%, Fructus Lycii 19.44%,
Radix Polygalae (processed with honey) 5.18%, Rhizoma Drynariae 4.53%,
Radix Cynanchi Auriculati 10.37%, Rhizoma Polygonati 10.37%,
Rhizoma Acori Graminei 10.37%, Petiolus nelumbinis 9.07%,
Radix Curcumae 3.24%, Fructus Perillae (stir-fry) 5.18%,
Cornu Cervi Pantotrichum 1.30%, Herba Cistanches 9.07%,
Medulla sus domestica 8.64%.
Nourishing the brain and improving intelligence medicine of the present invention can be made into various medicinal preparation for oral administration, as decoction, capsule, tablet, granule.
Second purpose of the present invention is achieved in that preparation method of the present invention comprises the steps:
Aforementioned 13 flavor crude drug, the Radix Cynanchi Auriculati of getting Radix Ginseng, Cornu Cervi Pantotrichum, 1/4 amount is ground into fine powder, and is standby; Get Rhizoma Acori Graminei, Radix Curcumae pulverizing back extraction volatile oil, the aqueous solution after distillation device is in addition collected, and is standby; Its medicinal residues and Fructus Lycii, Rhizoma Polygonati, Petiolus nelumbinis, Herba Cistanches, Radix Polygalae, Rhizoma Drynariae, Fructus Perillae, the Radix Cynanchi Auriculati of 3/4 amount decocts with water, add 8 successively, 7,6 times of water gagings, decoct 2 respectively, 1,1 hour, filter, collecting decoction is with aforementioned Rhizoma Acori Graminei, the aqueous solution of Radix Curcumae merges, and is concentrated into relative density and is 1.15-1.20 (50 ℃ time measure), adding ethanol makes and contains the alcohol amount and reach 65%, standing over night filters, and precipitation reuse ethanol is washed once, filter, merging filtrate and washing liquid, reclaiming ethanol to relative density is the extractum of (80 ℃ of surveys) about 1.15-1.20, adds pig's brain powder and the 1/4 above-mentioned Radix Cynanchi Auriculati of measuring, Radix Ginseng, Pulveratum Cornu Cervi Pantotrichum and appropriate amount of starch stir, dry, be ground into fine powder, spray adds the above-mentioned Rhizoma Acori Graminei with dissolve with ethanol, the volatile oil of Radix Curcumae stirs, cold drying, granulate, incapsulate, promptly.
Preparation technology's science of the present invention and rationally, determine the production technology of science according to the character of each raw material the effective elements of the medicine in the raw material, this medicine has qualitative preferably quality control standard (Fructus Lycii, Rhizoma Acori Graminei, Radix Cynanchi Auriculati, Radix Polygalae and Radix Ginseng), thereby has guaranteed the quality standard of this medicine.
Nourishing the brain and improving intelligence medicine of the present invention is as follows with the theory of Chinese medical science elaboration indication pathogenesis and the rule of treatment:
Dementia many by brain overwork or incoordination of seven emotions and suffer from for a long time quench one's thirst, the disease of apoplexy, cause brains to lose and support, mind is injured, meridians are not smooth, blood is capable unfavorable, stasis is the stasis of blood, and the Jin Shui in the congestion to exosmose be drink, its stasis of blood expectorant key network that stagnates is hoodwinked gods and is formed this disease.Brain is supported in the suitable the kidney invigorating of method, and collateral dredgingization stagnates, nourshing blood and promoting blood circulation, and it is scorching main to eliminate phlegm for resuscitation, and this gives birth in the brain " pipe " through meaning " kidney is given birth to marrow, and marrow is given birth to brain, the brain being the reservoir of the marrow ", the house of mental activity for kidney.
By monarch, minister, help, make the compatibility of principles of formulating prescriptions analysis nourishing the brain and improving intelligence medicine material of the present invention medicine as follows:
The crude drug of this medicine is made up of 13 flavor medicines, is odd-prescription, and due to illness the position is on brain is, last person is near, so element asks that the most pure virginity will expound greatly: " odd-prescriptions are used to treat newly affected diseases ", " monarch's two ministers three strange system also ", so get Radix Ginseng, Fructus Lycii two medicines for monarch, use honey polygala root, Rhizoma Drynariae, Radix Cynanchi Auriculati three medicines are minister.Monarch uses Radix Ginseng, sweet-bitter flavor, and temperature is slightly cold, and mends very unit and supplementing blood and promoting the production of body fluid helps Wei Chongying, settling five organs and the mind calming and mentality promoting, benefaction venation (book on Chinese herbal medicine is just read) is mended and manage it empty air-flow stagnant, and " blood bring about the desired sensation then warm it " follows capable and the stasis of blood not; The sweet Wen Errun of Fructus Lycii, the moon of tonifying liver lies prostrate to make in the liver-yang, and it is gentle that the moon of kidney tonifying water is not given birth to deficiency-heat to make the sun volt and not high, and vital essence is strengthened and mended marrow: beneficial brain is refreshing by force; Minister is got Rhizoma Drynariae, and bitter in the mouth, temperature are gone into the kidney liver, and essence is added in the kidney invigorating, and replenishing vital QI with drugs of warm nature is unit down, can draw to rise floating heat and be hidden in part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels bandits lair, and the row of invigorating blood circulation stagnates and do not stay the stasis of blood and degassing, and the person of closing opens (book on Chinese herbal medicine collection will).Radix Cynanchi Auriculati is bitter sweet puckery, tepor, and with its bitter hard kidney, sweet beneficial blood, temperature energy tonifying liver is held back vital essence, life essence-filling, marrow-benefitting, the marrow brain of supplementing nutrition; The Radix Polygalae acrid in the mouth, temperature, the smart will by force of benefit, the sharp key of eliminating phlegm is gone up the logical state of mind of happy gas, and by staying refreshment, three medicines are that minister is tied mutually, and essence is added in the kidney invigorating, and the liver benefiting dredge the meridian passage is eliminated phlegm for resuscitation, and mends very unit with principal drug assistance, and settling five organs is supported brain benefit god, and strong will is by slow-witted merit.The adjuvant drug sweet in the mouth of Rhizoma Polygonati, invigorating the spleen and replenishing QI, settling five organs and six internal organs, qiactivity of triple energizer is unobstructed, adds the smart marrow of mending and makes light of one's life by commiting suicide anti-old; It is arduous to take Rhizoma Acori Graminei, the machine that can declare conscience gasification, happy hole, sharp nine orifices, improve visual and auditory acuity, the Fructus Alpiniae Oxyphyllae of prolonging life, height do not wane always (herbal former through meeting); Little hardship of Petiolus nelumbinis, property hollow, its showplace shake, the machine of the logical taste lifting of a surname, calm maincenter, the ventilation Shujin rises Tianjin and quenches the thirst; The sweet salty tepor of Herba Cistanches, the kidney invigorating and the gate of vitality be fire mutually, high replenishing vital essence and blood, moistening dryness for relaxing bowels; The hot temperature of Fructus Perillae embellishes but not dry, the performance therapeutic method to keep the adverse QI flowing downwards, and the clearing away phlegm eliminating stagnation is mended one with Radix Ginseng 5 usefulness one and is loose, and one rise and one drop then QI and blood does not stagnate, and messenger drug is arduous flat with Radix Curcumae, falls after rising, and the removing blood stasis tissue regeneration promoting can remove mental confusion due to phlegm, dissipating depression of QI dispelling stagnant Qi; The sweet temperature of Cornu Cervi Pantotrichum, it is supporing yang to mend fire, spermatogenesis benefit marrow, the wind syndrome of head of dispelling is dizzy clearly, Medulla sus domestica is sweet cold, and three dizziness due to wind pathogen cranial tinnituss can lead to the kidney gate of vitality, the benefit marrow is supported brain, and assistant makes to amount to mutually plays energy supplementing the brain refreshment Fructus Alpiniae Oxyphyllae on the medicine that draws the monarch and his subjects, next accent internal organs, battalion's negative and positive, qi and blood circulation promotion, smooth meridians, to reach the body the exterior and the interior, biochemical up and down meritorious, metabolism is vigorous, brains must be answered, and refreshing clear intelligence is given birth to, stay disappear clever.
The acute toxicity test of nourishing the brain and improving intelligence medicine of the present invention is as follows:
Medicament capsule powder of the present invention is made into 0.8g extractum (2.12g crude drug)/ml suspension, give hungry 16 hours mouse stomach 40ml/kg, irritated stomach 2 times in 20 minutes, only mice is movable in 30 minutes after administration reduces, the movable recovery normally after 1 hour observed and do not had dead the generation in 7 days.Cause is limited to the administration volume and liquor strength can't increase again, so fail to measure the LD50 of this medicine.The maximum tolerated dose of this medicine is greater than 170g (crude drug)/kg, is 802 times of clinical human dosage (maximum tolerated dose ÷ people's per kilogram of body weight dosage: 170g/kg ÷ (0.4g/ grain * 12 * 2.65g (crude drug)/g extractum) ÷ 60kg (body weight for each person)=901.9 times).As seen this medicine clinical application will be very safe.
The long term toxicity test of nourishing the brain and improving intelligence medicine of the present invention is as follows:
By maximum tolerated dose 1/8 ((17g (crude drug)/kg) irritates the stomach medicine 1 time for rat every day to 21g (crude drug)/kg) and 1/10, and successive administration 90 days does not have obvious influence to rat diet, activity and body weight gain.Routine blood test, liver function there is not influence yet.Check pathological section is no abnormality seen also.The above results shows that this medicine is taken for a long time will be as safe as a house.
The health-care effect of medicine of the present invention and the safety of medicine have been carried out clinical observation research, have observed, obtained better curative effect, be reported as follows through 120 examples:
1. diagnostic criteria: according to " the dull-witted clinical research guideline of new Chinese medicine treatment ";
2. case physical data:
All observe among the case 120 routine patients, male 65 people, women 55 people, 50-60 year 37 examples, 61-70 year 38 examples, 71-80 year 45 examples, maximum 78 years old age, minimal ages 50 years old, 67 years old mean age.The longest course of disease 2 years, the shortest 1 year, average course of disease 1 year half.
3. the dosage and the course of treatment:
Be a course of treatment all around, each medicament capsule 2-3 grain of the present invention (every of 0.45g/), every day 3 times.
The result shows, medicament capsule of the present invention has the effect of symptoms such as obviously improving that dizziness and tinnitus, idle affection crouch, flushed cheeks night sweat, the soft flaccidity of bone are weak.Has obvious nootropic effect for dull-witted patient.Under observation, do not find any side effect and untoward reaction by the detection of safety indexes.Its total effective rate is 85.83%, is effective medicine of dementia deficiency of marrow-reservoir, caused by liver and kidney deficiency patient.
In addition, medicine of the present invention is also tried out in the low person of 100 many cases juvenile intelligences, and dosage is identical with the adult, and effective percentage is 64%.
The function of medicine of the present invention with cure mainly:
1, function: liver and kidney tonifying, benefiting QI and nourishing blood, nourishing the brain and improving intelligence.
2, cure mainly: deficiency of the liver and kindey, brain be refreshing to lose forgetful due to supporting, insomnia, dreaminess, diseases such as hypomnesis.
The invention will be further described below in conjunction with embodiment.
The specific embodiment
Embodiment one:
Present embodiment is a most preferred embodiment.
The prescription of medicine material is:
Radix Ginseng (sun-dried) 75g, Fructus Lycii 450g, Radix Polygalae (processed with honey) 120g, Rhizoma Drynariae 105g, Radix Cynanchi Auriculati 240g, Rhizoma Polygonati 240g, Rhizoma Acori Graminei 240g, Petiolus nelumbinis 210g, Radix Curcumae 75g, Fructus Perillae 120g (stir-fry), Cornu Cervi Pantotrichum 30g, Herba Cistanches 210g, Medulla sus domestica 200g.
Preparation method is as follows:
By above-mentioned prescription, the Radix Cynanchi Auriculati 60g that gets Radix Ginseng, Cornu Cervi Pantotrichum and 1/4 amount is ground into fine powder, and is standby; Rhizoma Acori Graminei, Radix Curcumae are pulverized in the rearmounted alembic and distilled 4 hours, collect volatile oil, and the aqueous solution after distillation device is in addition collected, and is standby; Last step Rhizoma Acori Graminei, medicinal residues of Radix Curcumae and Fructus Lycii, Rhizoma Polygonati, Petiolus nelumbinis, Herba Cistanches, Radix Polygalae, Rhizoma Drynariae, the Radix Cynanchi Auriculati 180g of Fructus Perillae and 3/4 amount decocts with water, add 8 successively, 7,6 times of water gagings decoct 2 respectively, 1,1 hour, filter, merging filtrate, with Rhizoma Acori Graminei, the aqueous solution of Radix Curcumae merges, and being concentrated into relative density is 1.15-1.20 (50 ℃), adds ethanol and makes and contain the alcohol amount and reach 65%, standing over night, filter, precipitation reuse ethanol is washed once, filters, merging filtrate and washing liquid, reclaiming ethanol to relative density is the extractum of 1.15-1.20 (80 ℃), adds pig's brain powder and above-mentioned Radix Cynanchi Auriculati, Radix Ginseng, the fine powder of Cornu Cervi Pantotrichum and starch 110g stir, dry, be ground into fine powder, spray adds the above-mentioned volatile oil with the 100ml dissolve with ethanol, stirs, cold drying, incapsulate, make 1000, promptly.
Embodiment two:
The prescription of medicine material is:
Radix Ginseng (sun-dried) 425g, Fructus Lycii 2000g,
Radix Polygalae (processed with honey) 370g, Rhizoma Drynariae 305g
Radix Cynanchi Auriculati 1000g, Rhizoma Polygonati 1000g,
Rhizoma Acori Graminei 930g, Petiolus nelumbinis 700g,
Radix Curcumae 205g, Fructus Perillae (stir-fry) 360g
Cornu Cervi Pantotrichum 130g, Herba Cistanches 1000g,
Pig's brain powder 650g.
Preparation process is with embodiment one.
Embodiment three:
The prescription of medicine material is:
Radix Ginseng (sun-dried) 25g, Fructus Lycii 150g,
Radix Polygalae (processed with honey) 40g, Rhizoma Drynariae 35g,
Radix Cynanchi Auriculati 70g, Rhizoma Polygonati 70g,
Rhizoma Acori Graminei 70g, Petiolus nelumbinis 60g,
Radix Curcumae 25g, Fructus Perillae (stir-fry) 40g,
Cornu Cervi Pantotrichum 10g, Herba Cistanches 68g,
Pig's brain powder 50g.
Preparation process is with embodiment one.
Embodiment four:
The prescription of medicine material is:
Radix Ginseng (sun-dried) 40g, Fructus Lycii 440g,
Radix Polygalae (processed with honey) 160g, Rhizoma Drynariae 120g,
Radix Cynanchi Auriculati 160g, Rhizoma Polygonati 160g,
Rhizoma Acori Graminei 160g, Petiolus nelumbinis 220g,
Radix Curcumae 20g, Fructus Perillae (stir-fry) 140g,
Cornu Cervi Pantotrichum 20g, Herba Cistanches 220g,
Pig's brain powder 140g.
Preparation process is with embodiment one.
Embodiment five:
The prescription of medicine material is:
Radix Ginseng (sun-dried) 100g, Fructus Lycii 400g,
Radix Polygalae (processed with honey) 120g, Rhizoma Drynariae 60g,
Radix Cynanchi Auriculati 240g, Rhizoma Polygonati 240g,
Rhizoma Acori Graminei 240g, Petiolus nelumbinis 140g,
Radix Curcumae 40g, Fructus Perillae (stir-fry) 120g,
Cornu Cervi Pantotrichum 20g, Herba Cistanches 140g,
Pig's brain powder 140g.
Preparation process is with embodiment one.
Embodiment six:
The prescription of medicine material is:
Radix Ginseng (sun-dried) 100g, Fructus Lycii 360g,
Radix Polygalae (processed with honey) 80g, Rhizoma Drynariae 40g,
Radix Cynanchi Auriculati 240g, Rhizoma Polygonati 200g,
Rhizoma Acori Graminei 200g, Petiolus nelumbinis 180g,
Radix Curcumae 100g, Fructus Perillae (stir-fry) 60g,
Cornu Cervi Pantotrichum 30g, Herba Cistanches 210g,
Pig's brain powder 200g.
Preparation process is with embodiment one.
Claims (4)
1. nourishing the brain and improving intelligence medicine is characterized in that it being the various medicinal preparation for oral administration of being made by following raw material:
Radix Ginseng (sun-dried) 2%-5%, Fructus Lycii 18%-22%,
Radix Polygalae (processed with honey) 4%-8%, Rhizoma Drynariae 2%-6%,
Radix Cynanchi Auriculati 8%-12%, Rhizoma Polygonati 8%-12%,
Rhizoma Acori Graminei 8%-12%, Petiolus nelumbinis 7%-11%,
Radix Curcumae 1%-5%, Fructus Perillae (stir-fry) 3%-7%,
Cornu Cervi Pantotrichum 1%-1.5%, Herba Cistanches 7%-11%,
Medulla sus domestica 7%-10%;
Aforementioned each percentage composition is weight percentage.
2. nourishing the brain and improving intelligence medicine according to claim 1 is characterized in that the weight percentage of each raw material is:
Radix Ginseng (sun-dried) 3.24%, Fructus Lycii 19.44%,
Radix Polygalae (processed with honey) 5.18%, Rhizoma Drynariae 4.53%,
Radix Cynanchi Auriculati 10.37%, Rhizoma Polygonati 10.37%,
Rhizoma Acori Graminei 10.37%, Petiolus nelumbinis 9.07%,
Radix Curcumae 3.24%, Fructus Perillae (stir-fry) 5.18%,
Cornu Cervi Pantotrichum 1.30%, Herba Cistanches 9.07%,
Medulla sus domestica 8.64%.
3. nourishing the brain and improving intelligence medicine according to claim 1 and 2 is characterized in that: described medicament is decoction, capsule, tablet or granule.
4. the preparation method of the described nourishing the brain and improving intelligence medicine of claim 1 is characterized in that comprising the steps:
Described 13 flavor crude drug, the Radix Cynanchi Auriculati of getting Radix Ginseng, Cornu Cervi Pantotrichum, 1/4 amount is ground into fine powder, and is standby; Get Rhizoma Acori Graminei, Radix Curcumae pulverizing back extraction volatile oil, the aqueous solution after distillation device is in addition collected, and is standby; Its medicinal residues and Fructus Lycii, Rhizoma Polygonati, Petiolus nelumbinis, Herba Cistanches, Radix Polygalae, Rhizoma Drynariae, Fructus Perillae, the Radix Cynanchi Auriculati of 3/4 amount decocts with water, add 8 successively, 7,6 times of water gagings, decoct 2 respectively, 1,1 hour, filter, collecting decoction is with aforementioned Rhizoma Acori Graminei, the aqueous solution of Radix Curcumae merges, and is concentrated into relative density and is 1.15-1.20 (50 ℃ time measure), adding ethanol makes and contains the alcohol amount and reach 65%, standing over night filters, and precipitation reuse ethanol is washed once, filter, merging filtrate and washing liquid, reclaiming ethanol to relative density is the extractum of (80 ℃ of surveys) about 1.15-1.20, adds pig's brain powder and the 1/4 above-mentioned Radix Cynanchi Auriculati of measuring, Radix Ginseng, Pulveratum Cornu Cervi Pantotrichum and appropriate amount of starch stir, dry, be ground into fine powder, spray adds the above-mentioned Rhizoma Acori Graminei with dissolve with ethanol, the volatile oil of Radix Curcumae stirs, cold drying, granulate, incapsulate, promptly.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101143181B (en) * | 2006-09-12 | 2010-11-03 | 广州中医药大学第二附属医院 | Traditional Chinese medicinal composition for treating senile dementia and preparation method and application thereof |
| CN105148022A (en) * | 2015-09-30 | 2015-12-16 | 郑梅 | Preparation for treating senile dementia and preparation method |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1059582C (en) * | 1996-03-12 | 2000-12-20 | 吴世鑫 | Traditional Chinese medicine of set prescription with function of promoting intelligence and prolonging life-span |
| CN1181966A (en) * | 1997-09-19 | 1998-05-20 | 薛廷民 | Medicine for senile dementia and its preparation |
| CN1293990A (en) * | 1999-10-25 | 2001-05-09 | 湖南中医学院 | Medicine 'Changlongdan' |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101143181B (en) * | 2006-09-12 | 2010-11-03 | 广州中医药大学第二附属医院 | Traditional Chinese medicinal composition for treating senile dementia and preparation method and application thereof |
| CN105148022A (en) * | 2015-09-30 | 2015-12-16 | 郑梅 | Preparation for treating senile dementia and preparation method |
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