CN1572802A - Chinese yam polysaccharide and ferrum compound and preparation process - Google Patents
Chinese yam polysaccharide and ferrum compound and preparation process Download PDFInfo
- Publication number
- CN1572802A CN1572802A CN 03159291 CN03159291A CN1572802A CN 1572802 A CN1572802 A CN 1572802A CN 03159291 CN03159291 CN 03159291 CN 03159291 A CN03159291 A CN 03159291A CN 1572802 A CN1572802 A CN 1572802A
- Authority
- CN
- China
- Prior art keywords
- iron
- yam polysaccharide
- polysaccharide
- tartrate
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
山药多糖－铁复合物及其制备工艺，属于多糖复合物技术领域。取山药多糖和水溶性柠檬酸盐或者酒石酸盐溶解于蒸馏水中，水浴加热、搅拌下滴加二价铁或者三价铁的化合物的水溶液，滴加完毕再反应0.5－2小时；冷却，反应液中加入乙醇醇沉、洗涤，得山药多糖－铁复合物；山药多糖与水溶性柠檬酸盐或者酒石酸盐、二价铁或者三价铁的化合物的质量比为1.5－8.5∶3－6∶3－10.5。所得复合物中，铁和山药多糖的质量含量分别为20－40％、10－50％之间。山药多糖－二价铁复合物和山药多糖－三价铁复合物25℃在100毫升水中溶解度分别为6－7克、10－12克。本发明产品溶出性能和稳定性较好，其水溶液呈中性，可替代现有补铁剂对人体有效补铁。The yam polysaccharide-iron compound and its preparation process belong to the technical field of polysaccharide compound. Dissolve yam polysaccharide and water-soluble citrate or tartrate in distilled water, add the aqueous solution of divalent iron or ferric iron compound dropwise under heating and stirring in a water bath, and react for 0.5-2 hours after the dropwise addition; cool, the reaction solution Add ethanol to alcohol for precipitation and washing to obtain yam polysaccharide-iron complex; the mass ratio of yam polysaccharide to water-soluble citrate or tartrate, divalent iron or ferric iron compound is 1.5-8.5:3-6:3 -10.5. In the obtained compound, the mass contents of iron and yam polysaccharide are respectively between 20-40% and 10-50%. The solubility of the yam polysaccharide-divalent iron complex and the yam polysaccharide-ferric iron complex in 100 ml of water at 25°C is 6-7 grams and 10-12 grams respectively. The product of the invention has better dissolution performance and stability, and its aqueous solution is neutral, which can replace existing iron supplements to effectively supplement iron for human body.
Description
Technical field
The invention belongs to the polysaccharide compound technical field, particularly a kind of Chinese yam polysaccharide-iron complexes and preparation technology thereof.
Background technology
Polysaccharide is from the natural macromolecular material in higher plant, animal, the microorganism cells, it is the high molecular polymer that forms in the biological vital movement, be the important component part of Living organism, with protein, nucleic acid and become most important three kinds of biomacromolecules.Polysaccharide molecular weight is big, polarity is big, complex structure, be difficult for to form crystallization, has very big difficulty aspect separation and purification and structure evaluation.Chinese scholars studies show that polysaccharide not only can be treated the cancer that body immune system is subjected to major injury, can treat the damaged disease of panimmunity again.As medicine, the more important thing is that its cytotoxicity is minimum.During tumour, it directly kills the tumour cell of growing unlike general chemotherapeutics in treatment, thereby but promote cell and humoral immune reaction to reach to suppress and the effect of elimination tumour cell, very little to normal impact cell.
China's Chinese yam aboundresources, only the Wuzhi of Henan Province's JIAOZUO AREA, Wen County, Qinyang (celebrating mansion, old genus bosom, the rapid-result RHIIZOMA DIOSCOREAE frOm Henan of China Dioscorea of the institute Chinese yam that produces opposita Thunb) annual output Chinese yam is healed 1,000,000 tons.Place of production Chinese yam still adopts traditional method to concoct process complexity, labor intensive at present.And concocting process will be bleached with sterilization with sulfur fumigation, may cause sulphur residual too high or produce harmful sulfide.
Summary of the invention
The object of the invention is to provide a kind of Chinese yam polysaccharide-iron complexes and preparation technology thereof.
For reaching above-mentioned purpose, the present invention adopts following technical scheme: Chinese yam polysaccharide-iron complexes, and wherein the mass content of iron is 20-40%, Chinese yam polysaccharide content is between 10-50%.
It is Chinese yam polysaccharide-ferrous iron mixture, 25 ℃ in 100 ml waters solubleness be 6-7 gram.
It is Chinese yam polysaccharide-ferric iron mixture, 25 ℃ in 100 ml waters solubleness be 10-12 gram.
Chinese yam polysaccharide-iron complexes preparation technology is got Chinese yam polysaccharide and water-soluble citrate or tartrate and is dissolved in the distilled water, and heating in water bath, stirring drip the aqueous solution of ferrous iron or ferric compound down, dropwise and react 0.5-2 hour again; Cooling adds ethanol alcohol precipitation, washing in the reaction solution, get Chinese yam polysaccharide-iron complexes; The mass ratio of Chinese yam polysaccharide and water-soluble citrate or tartrate, ferrous iron or ferric compound is 1.5-8.5: 3-6: 3-10.5.
Citrate trianion is trisodium citrate or citric acid tri potassium, and tartrate is sodium tartrate or soluble tartrate, and the compound of iron is iron(ic) chloride or ferrous ammonium sulphate.
Citrate trianion is a trisodium citrate, and tartrate is a sodium tartrate.
Polysaccharide concentration is 1-5g/250ml, and trisodium citrate concentration is 0.1-0.3mol/l, and the concentration of iron(ic) chloride is 0.2-0.6mol/l, reaction solution PH=7-8.
Polysaccharide concentration is 1-5g/250ml, and sodium tartrate concentration is 0.1-0.3mol/l, and the concentration of ferrous ammonium sulphate is 0.2-0.6mol/l, reaction solution PH=7-8.
Alcohol precipitation gained filter residue with 95% ethanol, dehydrated alcohol, acetone, ether washing, gets powdery Chinese yam polysaccharide-iron complexes through vacuum-drying or lyophilize successively.
The present invention utilizes resourceful Chinese yam first, from the Chinese yam polysaccharide in the Chinese yam and ferrous iron or the reaction of ferric water-soluble salt, makes Chinese yam polysaccharide-iron complexes (complex compound).Utilize mass content that atomic absorption, phenanthroline spectrophotometry and sulfuric acid phenol colour developing spectrophotometry goes out iron wherein between 20-40%, the mass content of polysaccharide is between 10-50%.Under 25 ℃ of temperature, the Chinese yam polysaccharide-solubleness of ferrous iron mixture in 100 ml waters is the 6-7 gram, and the Chinese yam polysaccharide-solubleness of ferric iron mixture in 100 ml waters is the 10-12 gram.Chinese yam polysaccharide-iron complexes dissolving out capability and stability better, and its aqueous solution is neutral, near the human body fluid pH value.Alternative existing benefit chalybeate (ferrous sulfate, the acid of coral amber are ferrous, Ferrous Gluconate etc.) to compensating iron for human, can avoid using existing stimulation side effect of mending chalybeate to the human intestines and stomach.In the reaction process, iron ion and citrate ion form the complex compound ironic citrate, ironic citrate is converted into citric acid polymerization iron under alkaline condition, Chinese yam polysaccharide is with the surperficial and polymerization iron phase mutual effect at polymerization iron nuclear of its sugar chain, generate stable Chinese yam polysaccharide-citric acid-polymerization iron complexes, i.e. Chinese yam polysaccharide-iron complexes.Preparation technology among the present invention, raw material is easy to get, and processing step is few, and the no three wastes produce.
Embodiment
Embodiment 1, Chinese yam polysaccharide-iron complexes preparation technology are got the Chinese yam polysaccharide aqueous solution (3.0012g/250ml) 14ml, trisodium citrate aqueous solution (0.1388mol/l) 5ml, press 1ml/ minute speed and drip FeCl
3The aqueous solution (0.4382mol/l) 5ml adjusts between the reaction solution PH=7-8 with the NaOH aqueous solution (3mol/l), and 70 ℃ of heating in water bath reacted 1 hour down, cooling, centrifugation.Add 95% ethanol of 4 times of amounts (volume) in the supernatant liquor, leave standstill in the refrigerator, filter, with 95% ethanol, dehydrated alcohol, acetone, anhydrous diethyl ether washing, it is Chinese yam polysaccharide-ferric iron mixture that vacuum-drying gets the red-brown powder to filter residue successively.Wherein the Chinese yam polysaccharide mass content 48.3%, and ferric iron mass content 21.8%, the solubleness under 25 ℃ of temperature of mixture in 100 ml waters are 10.8 grams.
In embodiment 2, the present embodiment, the Chinese yam polysaccharide aqueous solution (1.9586g/250ml) consumption 20ml, trisodium citrate substitute the sodium tartrate aqueous solution (0.1392mol/l) consumption 5ml, FeCl with sodium tartrate
3The aqueous solution (0.5477mol/l) consumption 4ml, other are with embodiment 1.Chinese yam polysaccharide mass content 46.2% in gained Chinese yam polysaccharide-ferric iron mixture, ferric iron mass content 32.1%, the solubleness under 25 ℃ of temperature of mixture in 100 ml waters are 11.2 grams.
In embodiment 3, the present embodiment, the Chinese yam polysaccharide aqueous solution (1.9586g/250ml) consumption 20ml, trisodium citrate substitute the sodium tartrate aqueous solution (0.1392mol/l) consumption 5ml, FeCl with sodium tartrate
3The aqueous solution (0.5477mol/l) consumption 4ml, solution PH is adjusted to 7-8 with aqueous sodium carbonate, 90 ℃ of temperature of reaction, 2 hours reaction times.Other are with embodiment 1.Chinese yam polysaccharide mass content 37.2% in gained Chinese yam polysaccharide-ferric iron mixture, ferric iron mass content 20.7%, the solubleness under 25 ℃ of temperature of mixture in 100 ml waters are 11.4 grams.
In embodiment 4, the present embodiment, the Chinese yam polysaccharide aqueous solution (1.9586g/250ml) consumption 20ml, trisodium citrate aqueous solution (0.1392mol/l) consumption 5ml, FeCl
3The aqueous solution (NH
4)
2Fe (SO
4)
2The aqueous solution substitutes, (NH
4)
2Fe (SO
4)
2The aqueous solution (0.5033mol/l) consumption 10ml, pH value of solution is adjusted to 7-8 with the NaOH aqueous solution, 80 ℃ of temperature of reaction, 2 hours reaction times.Other are with embodiment 1.Chinese yam polysaccharide mass content 18.6% in gained Chinese yam polysaccharide-ferrous iron mixture, ferrous iron mass content 23.6%, the solubleness under 25 ℃ of temperature of mixture in 100 ml waters are 6.6 grams.
Claims (9)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB031592910A CN100362021C (en) | 2003-06-06 | 2003-09-16 | Chinese yam polysaccharide-iron complex and its preparation process |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN03126197.3 | 2003-06-06 | ||
| CN03126197 | 2003-06-06 | ||
| CNB031592910A CN100362021C (en) | 2003-06-06 | 2003-09-16 | Chinese yam polysaccharide-iron complex and its preparation process |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1572802A true CN1572802A (en) | 2005-02-02 |
| CN100362021C CN100362021C (en) | 2008-01-16 |
Family
ID=34523617
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB031592910A Expired - Fee Related CN100362021C (en) | 2003-06-06 | 2003-09-16 | Chinese yam polysaccharide-iron complex and its preparation process |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN100362021C (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101328222B (en) * | 2007-06-20 | 2011-05-18 | 赵玉英 | Liquorice polyose metal complexes and preparation thereof |
| CN107325198A (en) * | 2017-07-27 | 2017-11-07 | 福建农林大学 | A kind of preparation method and applications of Chinese yam polysaccharide chromic compound |
| CN107417802A (en) * | 2017-07-12 | 2017-12-01 | 河南大学 | A kind of preparation method and applications of the Chinese yam polysaccharide Zn complex with hypoglycemic effect |
| CN110212192A (en) * | 2019-06-25 | 2019-09-06 | 河南大学 | A kind of adjustable nano ferriferrous oxide composite material and preparation method of cladding carbon layers having thicknesses and application |
| CN111567717A (en) * | 2020-05-27 | 2020-08-25 | 河南大学 | A kind of yam mucilage-nano zinc oxide solution and its preparation method and application |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6780602B2 (en) * | 2001-11-01 | 2004-08-24 | Microbiosystems, Limited Partnership | Taxonomic identification of pathogenic microorganisms and their toxic proteins |
-
2003
- 2003-09-16 CN CNB031592910A patent/CN100362021C/en not_active Expired - Fee Related
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101328222B (en) * | 2007-06-20 | 2011-05-18 | 赵玉英 | Liquorice polyose metal complexes and preparation thereof |
| CN107417802A (en) * | 2017-07-12 | 2017-12-01 | 河南大学 | A kind of preparation method and applications of the Chinese yam polysaccharide Zn complex with hypoglycemic effect |
| CN107325198A (en) * | 2017-07-27 | 2017-11-07 | 福建农林大学 | A kind of preparation method and applications of Chinese yam polysaccharide chromic compound |
| CN110212192A (en) * | 2019-06-25 | 2019-09-06 | 河南大学 | A kind of adjustable nano ferriferrous oxide composite material and preparation method of cladding carbon layers having thicknesses and application |
| CN111567717A (en) * | 2020-05-27 | 2020-08-25 | 河南大学 | A kind of yam mucilage-nano zinc oxide solution and its preparation method and application |
Also Published As
| Publication number | Publication date |
|---|---|
| CN100362021C (en) | 2008-01-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US20220356272A1 (en) | Processes for extracting and purifying chitin by using green solvents | |
| CN102276753B (en) | Method for preparing polyporus selenium polysaccharide | |
| Feng et al. | Advances on novel iron saccharide-iron (III) complexes as nutritional supplements | |
| CN101104646A (en) | Preparation method and application of selenized Eucheuma polysaccharide | |
| CN109776694B (en) | Preparation method and application of copper, iron and zinc triple chelate of brown algae polysaccharide | |
| CN102860512B (en) | Preparation method of black-bone chicken peptide and iron chelated biological iron supplement | |
| CN103330718B (en) | Preparation method of gynostemma pentaphyllum polysaccharide-iron complex | |
| CN1572802A (en) | Chinese yam polysaccharide and ferrum compound and preparation process | |
| CN105924535B (en) | A kind of preparation method of astragalus polyose iron | |
| KR20160149748A (en) | Method for producing higher-pyrity and depolymerizing fucoidan extracted from brown algae | |
| CN116120478A (en) | Fucoidin iron complex and preparation method and application thereof | |
| CN114053302A (en) | Preparation of compound edible fungus polysaccharide compound with anti-fatigue effect | |
| CN115336757A (en) | Method for preparing water-soluble soybean polysaccharide calcium chelate with assistance of high-voltage pulse electric field | |
| CN119798474A (en) | Mulberry leaf polysaccharide iron and preparation method and application thereof | |
| CN106631848B (en) | Preparation method of lysine chelated calcium by taking bay scallop shells as calcium source | |
| CN101157710B (en) | Method for preparing iron supplementary carboxymethyl Chitosan oligosaccharide ferrous | |
| CN112300299A (en) | Preparation method and application of zinc and calcium polysaccharide complex | |
| CA2497435A1 (en) | Use of metal chelates in human or animal feeding | |
| CN100542977C (en) | A kind of functional water containing cationic polymer and its preparation method | |
| CN106928078A (en) | A kind of threonine chelated iron and its application | |
| KR20050122289A (en) | Manufacturing process of chitosan-selenium complex | |
| CN113621043B (en) | Preparation method of high-oxidation-resistance bioactive peptide | |
| CN110250318A (en) | A kind of preparation method of selenium-rich soybean protein | |
| CN117088927B (en) | Preparation method and application of oligosaccharide chelated iron with immunoregulation effect | |
| CN111264832A (en) | A kind of seaweed iodized salt and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| ASS | Succession or assignment of patent right |
Owner name: BAOHETANG (JIAOZUO) PHARMACEUTICAL CO., LTD. Free format text: FORMER OWNER: HENAN UNIVERSITY Effective date: 20110812 |
|
| C41 | Transfer of patent application or patent right or utility model | ||
| COR | Change of bibliographic data |
Free format text: CORRECT: ADDRESS; FROM: 475001 KAIFENG, HENAN PROVINCE TO: 454850 JIAOZUO, HENAN PROVINCE |
|
| TR01 | Transfer of patent right |
Effective date of registration: 20110812 Address after: 454850, Chengbei Industrial Zone, Jiaozuo, Henan, Wenxian County Patentee after: Bao Tong (Jiaozuo) Pharmaceutical Co., Ltd. Address before: 475001 Henan province city Minglun Street No. 85 Patentee before: Henan University |
|
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20080116 Termination date: 20190916 |
|
| CF01 | Termination of patent right due to non-payment of annual fee |