CN1565528A - Medicine for treating ovary cyst and its preparing process - Google Patents

Abstract

The invention provides a medicament for treating epoophoron cystis, wherein the medicament is prepared from Chinese medicinal herbs including red peony root, Chinese angelica root, white atractylodes rhizome, Poria cocos, European verbena, eupatene, immature bitter orange, sweetgum fruit, sea tangle, and cyathula root. The invention also relates to its preparation.

Description

A kind of medicine for the treatment of ovarian cyst and preparation method thereof

Technical field

The present invention relates to a kind of medicine for the treatment of ovarian cyst, is the Chinese patent medicine of feedstock production with the Chinese herbal medicine specifically, the invention still further relates to the preparation method of this medicine.

Background technology

Ovarian cyst is one of common benign tumor of gynecological, the women of-50 years old childbearing age of being more common in 20 years old, and its pathogenic factor and endocrine disturbance, unhealthy emotion influence, pelvic cavity sanitary condition difference are relevant, belong to " lump in the abdomen " category of the traditional Chinese medical science from symptom." Sanyin Ji Yi Bingzheng Fang Lun ": " how because of passages through which vital energy circulates loses in managing, puerperium is not good at nursing, internal damage by the excessive seven emotions, and the diseases caused by exogenous pathogenic factor six climate exopathogens, the negative and positive work and rest, diet raw food causes battalion then and cannot not defend defeatedly, and is new old not disobedient, with turbid through losing, drench to reveal and stagnate, for disease is an abdominal mass." it forms mainly is due to the function of five internal organs imbalance, and excited, irritability, easily worry, overwork, artificial abortion's art constitute the inducement of ovarian cyst formation, its clinical manifestation respectively has its characteristics.Hepatopathy is qi depression to blood stasis then, is detained with the passing of time, gradually to become poly-; The splenopathy is then wet contains, and gathers to be expectorant, and the expectorant stasis of blood is handed over resistance, forms cyst.It is formed on the basis of disorder of QI and blood, and the spleen kidney deficiency is basis of pathological changes, and the resistance of the stagnation of liver-QI stasis of blood is the mark of pathological changes, and influence each other is corresponding layer by layer each other, condenses to be piece.In the prior art, during treatment ovarian cyst, just merely rely on excision, its defective to be, the just focus of excision does not change the cause of disease, cures the symptoms, not the disease, and also has the probability of recurrence.In addition, excision also may cause the wound of the health internal organs that are difficult to repair.

Summary of the invention

Technical problem to be solved by this invention is at the deficiencies in the prior art, and proposing a kind of is raw material with the Chinese herbal medicine, reaches the medicine of the treatment ovarian cyst for the treatment of both the principal and secondary aspects of a disease effect by its pharmacological action.

Another technical problem to be solved by this invention is a kind of preparation method that has proposed the medicine of this treatment ovarian cyst.

Technical problem to be solved by this invention is to realize by following technical scheme.The present invention is a kind of medicine for the treatment of ovarian cyst, is characterized in, it is the medicament of being made by the following weight proportion raw material:

Radix Paeoniae Rubra 8-16 Radix Angelicae Sinensis 6-15 Rhizoma Atractylodis Macrocephalae 10-20

Poria 10-20 Herba Verbenae 6-15 Herba Lycopi 6-15

Fructus Aurantii Immaturus 4-10 Fructus Liquidambaris 4-10 Thallus Laminariae (Thallus Eckloniae) 8-16

Radix Cyathulae 4-10

Technical problem to be solved by this invention can also further realize by following technical scheme.Above-described a kind of medicine for the treatment of ovarian cyst is characterized in that wherein the weight proportion of each raw material is:

Radix Paeoniae Rubra 12 Radix Angelicae Sinensis 10 Rhizoma Atractylodis Macrocephalaes 15 Poria 15

Herba Verbenae 10 Herba Lycopi 10 Fructus Aurantii Immaturuss 6 Fructus Liquidambaris 6

Thallus Laminariae (Thallus Eckloniae) 12 Radix Cyathulaes 6

Technical problem to be solved by this invention can also further realize by following technical scheme.Above-described a kind of medicine for the treatment of ovarian cyst is characterized in, described medicament is a said dosage form on any pharmaceutics, and wherein, preferred dosage form is tablet or capsule or granule.

Technical problem to be solved by this invention can also further realize by following technical scheme.The preparation method of the medicine of above-described treatment ovarian cyst is characterized in,

(1) get the Rhizoma Atractylodis Macrocephalae, Radix Angelicae Sinensis, Fructus Aurantii Immaturus, Herba Lycopi earlier and add 5-15 times of water gaging, soaked 20-60 minute, extracted volatile oil 5-10 hour, it is standby to get volatile oil; Medical filtration, filtrate add 80-95% ethanol to be made and contains the alcohol amount and reach 50-70%, leaves standstill 8-15 hour, gets supernatant, standby;

(2) get above-mentioned volatile oil and wrap up with beta-schardinger dextrin-, wrappage is standby;

(3) get the above-mentioned Rhizoma Atractylodis Macrocephalae, Radix Angelicae Sinensis, Fructus Aurantii Immaturus, Herba Lycopi's residue, Herba Verbenae, Radix Paeoniae Rubra, Fructus Liquidambaris and add 5-15 and doubly measure 60-80% ethanol extraction twice, each 1-3 hour, extracting solution merged with supernatant, recovery ethanol, and medicinal liquid is standby;

(4) get Radix Cyathulae, Poria, Thallus Laminariae (Thallus Eckloniae) and add 6-15 times of water gaging, decoct 2-4 time, each 1-3 hour, concentrated medicament, centrifugal, centrifugal liquid and above-mentioned medicinal liquid are merged, relative density is the extractum of 1.10-1.35 when being evaporated to 50 ℃ of heat surveys, adding extractum weighs the adjuvant of 0.5～5 times of amount, and drying is ground into fine powder.

(5) add the volatile oil beta-cyclodextrin wrappage in above-mentioned fine powder, mixing is granulated, drying, and granulate promptly gets granule; Or with the granule compacting in flakes, the bag film-coat promptly gets tablet; Or granule incapsulated, promptly get capsule.

Below be the test of pesticide effectiveness that the inventor did:

Be subjected to the reagent thing: the present invention treats the medicine of ovarian cyst, dosage form: tablet, hereinafter to be referred as the NZPX sheet; NZPX sheet mice dosage is 12.8,6.4,3.2g crude drug/kg; Rat dosage is 6.4,3.2, three dosage groups of 1.6g crude drug/kg, clinical consumption is 30g, test dose is pressed animals and human beings, and (people is by 70 kilograms of calculating, dosage is 0.429g crude drug/kg) body surface coefficient conversion, middle dosage is equivalent to clinical equivalent dosage approximately, high dose is a times of middle dosage, and low dose is 1/2 of a middle dosage.Matched group gives the distilled water of equal volume.

Animal: white mice, Switzerland's kind, male, body weight 20 ± 1g; Rat, Wistar system, male, body weight 120 ± 10g provides by Chinese Academy of Medical Sciences's zooscopy, the animal quality certification number is respectively＜cures and moves word〉01-3008,01-3001.

One, analgesic activity

Be subjected to reagent thing, animal all the same.

Instrument: GJ-8402 type hot plate dolorimeter, the abundant radio of Anhui freshwater mussel two factories produce.

(1), mice hot plate method

Use the hot plate dolorimeter, temperature remains in 55 ℃, female mice is dropped on the hot plate, drop into hot plate to the index of the response time that metapedes occurs licking (incubation period) as the threshold of pain with the stopwatch record from mice, the previous day is picked out incubation period the 10-15 mice of second in experiment, retrial in second day once, irritated, blunt all reject need not, irritate stomach and be subjected to the reagent thing, each was surveyed once respectively in 0.5,1.0,2.0,3.0 hour behind the medicine, calculate the threshold of pain changing value of matched group and administration group, compare between organizing.By table 1 result as seen, significant analgesia role just occurred in 0.5 hour behind the NZPX sheet medicine, it acts on sustainable more than 3 hours.

Table 1NZPX sheet to the analgesic activity (hot plate method) of mice (n=10)

Threshold of pain changing value behind group dosage (g/kg) medicine (X ± S) second

0.5h 1.0h 2.0h 3.0h

Matched group--13.6 ± 2.0 14.1 ± 2.4 15.1 ± 2.3 16.2 ± 3.1

NZPX sheet 12.8 17.5 ± 2.5 ^{* *}19.1 ± 2.8 ^{* *}20.3 ± 3.1 ^{* *}21.4 ± 3.4 ^*

6.4 16.9±2.2 ^** 18.6±2.1 ^*** 19.7±2.8 ^*** 20.8±2.9 ^**

3.2 15.2±2.1 16.0±2.7 17.5±2.8 ^* 18.5±2.7

(2), mouse writhing method

Mice is pressed the body weight random packet, irritate stomach and be subjected to the reagent thing, 1 hour mouse peritoneal is injected 1.2% acetic acid 0.2ml behind the medicine, observed 20 minutes, body frequency (stretching hind leg, abdominal part contraction and distortion health) typically turned round in record, carry out statistical procedures to turn round the body number of times, and calculate the slip that the administration group is turned round the body number of times.

By table 2 result as seen, NZPX sheet 12.8,6.4, three dosage groups of 3.2g/kg all can obviously reduce mice and cause the occurrence frequency of turning round body because of acetic acid stimulates, and the suppression ratio of high dose group is up to 77.86%, and prompting NZPX sheet has stronger analgesic effect.

Table 2NZPX sheet is to the analgesic activity (mouse writhing method) of mice

Group dosage Mus number is turned round body number of times slip

(g/kg) (only) () (%)

Matched group--10 27.1 ± 4.5

NZPX sheet 12.8 10 6.2 ± 3.3 ^{* *}77.86

6.4 10 12.3±3.3 ^*** 54.61

3.2 10 15.1±4.2 ^*** 44.28

Each group is compared with matched group ^*P＜0.05, ^*P＜0.01, ^{* *}P＜0.001 (as follows)

(as follows)

(3), formaldehyde causes the pain method

It is subcutaneous that 3% formalin is injected mice front foot pawl back, is positioned over then in the 2000ml beaker, writes down the pain fraction reacted every 30 minutes.The pain reaction is with 2 grades of expressions of keeping the score.0 minute: the equal kiss the earth of front foot that the front foot of injection formaldehyde side and other side are not injected, walk about freely; 1 minute: the slight kiss the earth of front foot of injection formaldehyde side, body wt moved and are put in end injection parapodum on one side, obviously walk lamely when walking about; 2 minutes: the front foot of injection formaldehyde side lifted, and does not contact any ground.Mice the injection formaldehyde before half an hour gastric infusion, carry out statistical procedures with the pain fraction reacted.

Table 3NZPX sheet is to the analgesic activity (formaldehyde causes the pain method) of mice

Group dosage Mus number causes scorching back different time pain fraction reacted (X ± S)

(g/kg) (only) 0.5h 1.0h 2.0h 3.0h

Matched group--10 1.8 ± 0.5 1.8 ± 0.5 1.7 ± 0.6 1.5 ± 0.4

NZPX sheet 12.8 10 0.8 ± 0.4 ^{* *}0.9 ± 0.6 ^{* *}1.1 ± 0.5 ^*1.1 ± 0.6 ^*

6.4 10 0.9±0.7 ^*** 1.0±0.7 ^** 1.1±0.6 ^* 1.1±0.5 ^*

3.2 10 1.0±0.8 ^** 1.1±0.5 ^** 1.3±0.4 1.3±0.4

Table 3 result as can be seen, behind the injection proinflammatory agent formaldehyde, pain reaction promptly appears in mice.Cause scorching back half an hour, significant analgesia role all appears in all administration groups.NZPX sheet height, the effect of middle dosage group are the longest, sustainable more than 2 hours.

Two, the antiinflammatory action of NZPX sheet

Be subjected to reagent thing, animal all the same.

Reagent: Oleum Tiglii, Japan and light Co., Ltd. product, lot number: DCCL7737; Carrageenin, Sigma company product, lot number: 45F-0427.Instrument: uv-754 type spectrophotometer, medical analytical instrument factory in Shanghai produces.

(1), Oleum Tiglii is caused the influence of mice auricular concha swelling

Method: adopt the mice ear method.Mice is by the body weight random packet, gastric infusion, be applied to two sides, left ear front and back with 1% Oleum Tiglii 0.05ml after 1 hour, auris dextra is contrast, cause scorching back 4 hours mice is put to death, cut two ears along the auricle baseline, sweep away auricle respectively at same position, on electronic balance, weigh with the rustless steel punching pin of diameter 8mn.Weight difference with left and right sides auricle is the swelling value, compares between organizing with the t check.

Table 4 result as seen, three dosage groups of NZPX sheet all have the obvious suppression effect to the mice ear that Oleum Tiglii causes.

Table 4NZPX sheet brings out the inhibitory action of mouse ear edema to Oleum Tiglii

Group dosage Mus is counted the swollen swelling value suppression ratio of ear

(g/kg) (only) (X ± S) (%)

Matched group--10 20.0 ± 2.8

NZPX sheet 12.8 10 12.4 ± 2.6 ^{* *}38.0

6.4 10 13.9±2.8 ^*** 30.5

3.2 10 15.8±3.1 ^*** 21.0

(2), to the influence of mouse skin capillary permeability

Mice is by the body weight random packet, and oral administration is after 1 hour, and the blue 0.2ml/10g body weight of tail vein injection 0.5% ivens was distinguished melted paraxylene 0.04ml in the abdominal part of shaving hair after 15 minutes.Cause scorching back 15 minutes and put to death animal, cut the painted skin of abdominal part, shred, be placed on 6ml acetone: soaked 20 hours in distilled water (7: the 3) solution, 3000 rev/mins centrifugal 10 minutes, get supernatant in 754 type spectrophotometer 610nm wavelength colorimetrics, photometry density value.

Table 5NZPX sheet is to the influence of mouse skin capillary permeability

Group dosage Mus is counted the optical density value suppression ratio

(g/kg) (only) (X ± S) (%)

Matched group--10 0.363 ± 0.18

NZPX sheet 12.8 10 0.136 ± 0.05 ^{* * $}62.53

6.4 10 0.123±0.07 ^***￥ 66.00

3.2 10 0.170±0.15 ^** 53.16

The result shows by table 13, and three dosage groups of NZPX sheet xylol causes that the mouse skin capillary permeability increases tangible antagonism is arranged.

(3), to the inhibitory action of mice chondrus ocellatus Holmes colloidality ankle swelling

Method: measuring right side of mice foot sole of the foot thickness with peafowl board thickness gauge is basic value.Gastric infusion, behind the medicine 1 hour, cause inflammation with 1% carrageenin, every right side of mice foot plantar subcutaneous injection proinflammatory agent 0.04ml, each surveyed once sufficient sole of the foot thickness respectively in 1.0,2.0,4.0,6.0 hours to cause scorching back, calculate swelling value (cause inflammation back thickness and cause the poor of scorching preceding thickness), compare the diversity between each time point administration group and the matched group respectively.Viewing duration at 6 hours, three dosage groups of NZPX sheet on Carrageenan mice ankle swelling all has in various degree inhibition to imitate three dosage group on Carrageenan mice ankle swelling in various degree inhibition effect is all arranged, its acting duration is more than 6 hours, sees Table 6.

Table 6NZPX sheet is to the influence (n=10) of mice chondrus ocellatus Holmes colloidality ankle swelling

Group dosage caused scorching back swelling value (X ± S) second

(g/kg) 6h after the 4h administration after the 2h administration after the 1h administration after the administration

Matched group--1.08 ± 0.15 1.32 ± 0.16 1.39 ± 0.08 1.24 ± 0.12

NZPX 12.8 0.90±0.13 ^* 1.10±0.15 ^** 1.09±0.12 ^*** 0.95±0.18 ^***

6.4 0.90±0.15 ^* 1.04±0.17 ^*** 1.10±0.18 ^*** 0.92±0.15 ^***

3.2 1.01±0.18 1.05±0.10 ^** 1.13±0.12 ^* 0.96±0.11 ^***

Three, the effect of invigorating blood circulation

Be subjected to reagent thing, animal all the same.

Reagent: glucosan, Sweden Pharmacia company

Instrument: Olympus biological microscope.

To the microcirculatory influence of mice

Method: mice is divided into 5 groups at random by body weight, and gastric infusion is after 1 hour, and lumbar injection 1% pentobarbital sodium (50mg/kg) is anaesthetized.Cut off the mice tragus, be placed on the microscope carrier, select Mus ear same position caliber venule identical, that flow velocity is identical to observe, and write down the preceding blood flow rate of modeling, caliber size.Caudal vein is injected 5% glucosan by 1mg/kg and is caused the circulatory disturbance model, observes and write down the situation of change of blood flow rate, caliber immediately.The normal time of restoration of blood flow (less than 0.5 minute by 0.5 minute, greater than 30 minutes by 30 minutes).Carry out statistical procedures with the t check.

The flow velocity criterion:

Linear flow: flow velocity is fast, and is smooth streak, has no granular sensation, be judged to " ++ ++ ";

Grain stream: flow velocity is fast, is bar

Strand has granular sensation, be judged to " +++"; Unhurried current: blood flow is slow, and obvious granular sensation is arranged, and is judged to " ++ " as the silt sample;

Pendulum stream: obvious silt agglomerate, into stop, swing is judged to "+"; Stagnate: blood flow stops fully, is judged to "-".For ease of statistics, the blood flow rate numeric representation: " ++ ++ " be decided to be 4; " +++" be decided to be 3; " ++ " is decided to be 2; "+" is decided to be 1; "-" is decided to be 0.

Table 7NZPX sheet is to the microcirculatory influence of mice (X ± S)

Group dosage Mus is counted behind intravenous injection 5% glucosan changing value recovery time

(g/kg) (only) blood flow rate caliber (lattice) (branch)

Matched group--10-3.1 ± 0.61-0.4 ± 0.60 17.85 ± 8.97

NZPX sheet 12.8 10-1.3 ± 0.66 ^*0.1 ± 0.32 ^*1.23 ± 0.35 ^*

6.4 10 -1.8m0.93 ^** 0.1±0.35 ^* 1.32±0.33 ^**

3.2 10 -1.8±0.88 ^* 0.1±0.37 1.37±0.67 ^**

Annotate: 1 lattice are equivalent to 11.0um.

Table 7 result as can be seen, the NZPX sheet has significant protective effect to 5% glucosan induced mice microcirculation disturbance.5% glucosan can make Mice Auricle venule blood flow rate obviously slow down, and flow velocity is reduced to "+" from " ++ ++ ", obvious silt agglomerate occurs, and blood flow into stops, swing.And high, medium and low three the dosage groups of NZPX sheet all have fairly obvious protective effect to the microcirculation disturbance that glucosan caused, and blood flow rate is had slightly slow down, and have compared significant differences with matched group; Heavy dose of group has the effect of tangible expansion venule caliber; From the normal time result of restoration of blood flow, each dosage group of NZPX sheet all can significantly shorten the normal time of restoration of blood flow.

Experiment brief summary: have by above evidence NZPX sheet:

1, analgesic activity: the NZPX sheet all can significantly improve the heat-resisting pain threshold of mice in institute's amount of reagent scope; Reduce acetic acid stimulation the causing occurrence frequency of turning round body significantly, suppress formaldehyde and cause the pain reaction.The prompting medicine all has good analgesic effect to the pain that physical property and chemical irritation cause.

2, antiinflammatory action: the NZPX sheet all can significantly suppress Oleum Tiglii and cause mice ear in institute's amount of reagent scope; The mouse skin capillary permeability that antagonism dimethylbenzene causes increases; The mice ankle swelling that on Carrageenan causes has tangible regressive effect; Suppress the formation of rat granuloma tissue, its effect obviously.Above result shows that the NZPX sheet all has the obvious suppression effect to acute and chronic inflammation.

3, the effect of invigorating blood circulation: high, medium and low three the dosage groups of NZPX sheet have significant protective effect to 5% glucosan induced mice microcirculation disturbance.5% glucosan can make Mice Auricle venule blood flow rate obviously slow down, and slows down, has compared significant differences with matched group and high, medium and low three the dosage groups of NZPX sheet can make blood flow rate have slightly; Heavy dose of group has the effect of tangible expansion venule Guan Jing; All dosage groups all can significantly shorten the normal time of restoration of blood flow.

Compared with prior art, medicine of the present invention is used for the treatment of ovarian cyst, mends eliminating stagnation and closes, and treating both the principal and secondary aspects of a disease is on the basis of nourishing blood to suppress the hyperactive liver invigorating spleen to remove dampness, congestion must be gone, and phlegm-damp can be changed, and cyst fades, and patient only need take medicine continuously, the course of treatment is shorter, and no pain, treating both the principal and secondary aspects of a disease, and curative effect is reliable.Hospital preparation so that medicine of the present invention is made can reach 48.3% by 112 routine open clinical observation cure rates, and obvious effective rate reaches 39.6%, and the patient after the healing is no longer recurred, and still can normally give birth to.

The specific embodiment

Embodiment one.

A kind of medicine for the treatment of ovarian cyst, it be the medicament made by the following weight proportion raw material (unit: kilogram),

Radix Paeoniae Rubra 12 Radix Angelicae Sinensis 10 Rhizoma Atractylodis Macrocephalaes 15 Poria 15

Herba Verbenae 10 Herba Lycopi 10 Fructus Aurantii Immaturuss 6 Fructus Liquidambaris 6

Thallus Laminariae (Thallus Eckloniae) 12 Radix Cyathulaes 6

Extract active ingredient wherein according to a conventional method, add medical accessory, make tablet.

Embodiment two.

A kind of medicine for the treatment of ovarian cyst, it is the medicament of being made by the following weight proportion raw material (unit: restrain),

Radix Paeoniae Rubra 8 Radix Angelicae Sinensis 6 Rhizoma Atractylodis Macrocephalaes 10 Poria 10 Herba Verbenae

6 Herba Lycopi, 6 Fructus Aurantii Immaturuss, 4 Fructus Liquidambaris, 4 Thallus Laminariae (Thallus Eckloniae)s 8

Radix Cyathulae 4

Decoction according to a conventional method.

Embodiment three.

A kind of medicine for the treatment of ovarian cyst, it be the medicament made by the following weight proportion raw material (unit: kilogram),

Radix Paeoniae Rubra 16 Radix Angelicae Sinensis 15 Rhizoma Atractylodis Macrocephalaes 20 Poria 20

Herba Verbenae 15 Herba Lycopi 15 Fructus Aurantii Immaturuss 10 Fructus Liquidambaris 10

Thallus Laminariae (Thallus Eckloniae) 16 Radix Cyathulaes 10

Extract active ingredient wherein according to a conventional method, add medical accessory, make capsule.

Embodiment four.

A kind of medicine for the treatment of ovarian cyst, it be the medicament made by the following weight proportion raw material (unit: kilogram),

Radix Paeoniae Rubra 10 Radix Angelicae Sinensis 10 Rhizoma Atractylodis Macrocephalaes 15

Poria 15 Herba Verbenae 10 Herba Lycopi 12

Fructus Aurantii Immaturus 8 Fructus Liquidambaris 8 Thallus Laminariae (Thallus Eckloniae)s 10

Radix Cyathulae 8

Its preparation method is as follows:

(1) earlier get the Rhizoma Atractylodis Macrocephalae, Radix Angelicae Sinensis, Fructus Aurantii Immaturus, Herba Lycopi and add 5 times of water gagings, soaked 30 minutes by above-mentioned weight, extraction volatile oil 5 hours, it is standby to get volatile oil; Medical filtration, filtrate add 80% ethanol to be made and contains alcohol amount and reach 70%, leaves standstill 8 hours, gets supernatant, standby;

(2) get above-mentioned volatile oil and wrap up with beta-schardinger dextrin-, wrappage is standby;

(3) get the above-mentioned Rhizoma Atractylodis Macrocephalae, Radix Angelicae Sinensis, Fructus Aurantii Immaturus, Herba Lycopi's residue, Herba Verbenae, Radix Paeoniae Rubra, Fructus Liquidambaris and add 5 times of amount 80% ethanol extractions twice, each 1 hour, extracting solution merged with supernatant, recovery ethanol, and medicinal liquid is standby;

(4) get Radix Cyathulae, Poria, Thallus Laminariae (Thallus Eckloniae) and add 6 times of water gagings, decoct 2 times, each 1 hour, concentrated medicament, centrifugal, centrifugal liquid and above-mentioned medicinal liquid are merged, relative density is 1.35 extractum when being evaporated to 50 ℃ of heat surveys, adding extractum weighs the adjuvant of 0.5 times of amount, and drying is ground into fine powder.

(5) add the volatile oil beta-cyclodextrin wrappage in above-mentioned fine powder, mixing is granulated, drying, and granulate promptly gets granule.

Embodiment five.

A kind of medicine for the treatment of ovarian cyst, it be the medicament made by the following weight proportion raw material (unit: kilogram),

Radix Paeoniae Rubra 14 Radix Angelicae Sinensis 8 Rhizoma Atractylodis Macrocephalaes 12

Poria 16 Herba Verbenae 14 Herba Lycopi 12

Fructus Aurantii Immaturus 5 Fructus Liquidambaris 5 Thallus Laminariae (Thallus Eckloniae)s 14

Radix Cyathulae 5

Its preparation method is as follows:

(1) get the Rhizoma Atractylodis Macrocephalae, Radix Angelicae Sinensis, Fructus Aurantii Immaturus, Herba Lycopi earlier and add 15 times of water gagings, soaked 60 minutes, extracted volatile oil 10 hours, it is standby to get volatile oil; Medical filtration, filtrate add 95% ethanol to be made and contains alcohol amount and reach 60%, leaves standstill 15 hours, gets supernatant, standby;

(2) get above-mentioned volatile oil and wrap up with beta-schardinger dextrin-, wrappage is standby;

(3) get the above-mentioned Rhizoma Atractylodis Macrocephalae, Radix Angelicae Sinensis, Fructus Aurantii Immaturus, Herba Lycopi's residue, Herba Verbenae, Radix Paeoniae Rubra, Fructus Liquidambaris and add 15 times of amount 80% ethanol extractions twice, each 2 hours, extracting solution merged with supernatant, recovery ethanol, and medicinal liquid is standby;

(4) get Radix Cyathulae, Poria, Thallus Laminariae (Thallus Eckloniae) and add 10 times of water gagings, decoct 4 times, each 2 hours, concentrated medicament, centrifugal, centrifugal liquid and above-mentioned medicinal liquid are merged, relative density is 1.10 extractum when being evaporated to 50 ℃ of heat surveys, adding extractum weighs the adjuvant of 2 times of amounts, and drying is ground into fine powder.

(5) add the volatile oil beta-cyclodextrin wrappage in above-mentioned fine powder, mixing is granulated, drying, and granulate, with the granule compacting in flakes, the bag film-coat promptly gets tablet.

Embodiment six.

A kind of medicine for the treatment of ovarian cyst, it be the medicament made by the following weight proportion raw material (unit: kilogram),

Radix Paeoniae Rubra 12 Radix Angelicae Sinensis 10 Rhizoma Atractylodis Macrocephalaes 15 Poria 15

Herba Verbenae 10 Herba Lycopi 10 Fructus Aurantii Immaturuss 6 Fructus Liquidambaris 6

Thallus Laminariae (Thallus Eckloniae) 12 Radix Cyathulaes 6

Its preparation method is as follows:

(1) get the Rhizoma Atractylodis Macrocephalae, Radix Angelicae Sinensis, Fructus Aurantii Immaturus, Herba Lycopi earlier and add 10 times of water gagings, soaked 20 minutes, extracted volatile oil 10 hours, it is standby to get volatile oil; Medical filtration, filtrate add 90% ethanol to be made and contains alcohol amount and reach 70%, leaves standstill 10 hours, gets supernatant, standby;

(2) get above-mentioned volatile oil and wrap up with beta-schardinger dextrin-, wrappage is standby;

(3) get the above-mentioned Rhizoma Atractylodis Macrocephalae, Radix Angelicae Sinensis, Fructus Aurantii Immaturus, Herba Lycopi's residue, Herba Verbenae, Radix Paeoniae Rubra, Fructus Liquidambaris and add 10 times of amount 70% ethanol extractions twice, each 3 hours, extracting solution merged with supernatant, recovery ethanol, and medicinal liquid is standby;

(4) get Radix Cyathulae, Poria, Thallus Laminariae (Thallus Eckloniae) and add 10 times of water gagings, decoct 2 times, each 3 hours, concentrated medicament, centrifugal, centrifugal liquid and above-mentioned medicinal liquid are merged, relative density is 1.30 extractum when being evaporated to 50 ℃ of heat surveys, adding extractum weighs the adjuvant of 5 times of amounts, and drying is ground into fine powder.

(5) add the volatile oil beta-cyclodextrin wrappage in above-mentioned fine powder, mixing is granulated, drying, and granulate incapsulates granule, promptly gets capsule.

Claims (5)

1, a kind of medicine for the treatment of ovarian cyst, it is characterized in that, it is the medicament that is made of the raw material of following weight ratio: Paeoniae Rubra 8-16 Angelica 6-15 Atractylodes Rhizoma 10-20 Poria 10-20 Verbena 6-15 Eupatorium 6-15 Aurantium 4-10 Passepartout 4-10 Kelp 8-16 Sichuan Achyranthes 4-10 2. A medicine for treating ovarian cyst according to claim 1, wherein the weight ratio of each raw material is: Paeoniae Rubra 12 Angelica 10 Atractylodes Rhizome 15 Poria 15 Verbena 10 Zeeland 10 Citrus aurantium 6 Passepartout 6 Kelp 12 Sichuan Achyranthes 6 3. A medicine for treating ovarian cyst according to claim 1 or 2, characterized in that said medicine is any dosage form mentioned in pharmacy. 4. A medicine for treating ovarian cyst according to claim 3, characterized in that, said medicine is tablet, capsule or granule. 5. The preparation method of a medicine for treating ovarian cyst according to claim 4, characterized in that: (1) First take Atractylodes macrocephala, angelica, citrus aurantium, and euphemum, add 5-15 times the amount of water, soak for 20-60 minutes, extract the volatile oil for 5-10 hours, take the volatile oil for later use; filter the medicinal solution, add 80-95% ethanol to the filtrate to make When the alcohol content reaches 50-70%, let stand for 8-15 hours, take the supernatant, and set aside; (2) Take the above-mentioned volatile oil and wrap it with β-cyclodextrin, and wrap it for later use; (3) Get the above-mentioned Atractylodes macrocephala, angelica, citrus aurantium, Eupatorium residue, verbena, red peony root, Passepartout plus 5-15 times the amount of 60-80% ethanol to extract twice, each time for 1-3 hours, extract and The supernatants are combined, ethanol is recovered, and the medicinal solution is set aside; (4) Take Achyranthes bidentata, Poria cocos, and kelp, add 6-15 times the amount of water, decoct 2-4 times, 1-3 hours each time, concentrate the medicinal solution, centrifuge, combine the centrifugate with the above-mentioned medicinal solution, and decompress Concentrate to an extract with a relative density of 1.10-1.35 when thermally measured at 50°C, add excipients 0.5-5 times the weight of the extract, dry, and pulverize into fine powder. (5) Add volatile oil β-cyclodextrin wrapper to the above fine powder, mix evenly, granulate, dry, and granulate to obtain granules; or compress the granules into tablets and coat with film to obtain tablets; Or put the granules into capsules to obtain capsules.