CN1565183A - Bactericidal compositions containing enostroburin and thiocarbamate - Google Patents

Abstract

The invention discloses a bactericidal composition containing erythoxystrobin and any thiocarbamate bactericide, and the weight ratio of the two active components is 1:100 to 100:1. The thiocarbamate fungicides are selected from mancozeb, maneb, zinc, propineb, thiram, thiram salt, thiram, thiram or thiram. The weight percent content of active components in the composition is 0.5-95%. The composition contains at least two carriers, at least one of which is a surfactant. The composition can be prepared into dosage forms such as suspension concentrate, (water) emulsion, wettable powder, (water dispersion) granule, etc., and is used for preventing and treating plant diseases caused by pathogenic fungi.

Description

Fungicidal composition of erythoxystrobin and thiocarbamate

technical field

The invention belongs to the field of agricultural fungicides.

Background technique

Enoxstrobin is an excellent fungicide for the control of various plant diseases such as grains, rice, fruits, vegetables and economic crops. It has a wide bactericidal spectrum, high activity, preventive and therapeutic effects, and has good compatibility with environmental organisms , It has a good control effect on various plant diseases caused by flagellate fungi, combined fungi, ascomycetes, basidiomycetes and deuteromycetes. The compound was created by China Shenyang Research Institute of Chemical Industry and disclosed for the first time in CN1191670A. Enoxstrobin is a new type of methoxyacrylate fungicide. This type of fungicide has high activity and low dosage. It has therapeutic and protective effects and is widely used to prevent and control crop diseases. However, because the action site of this type of fungicide is very single, the bacteria will produce adaptive variation of the agent, which will reduce the control effect of the agent or even make it ineffective, resulting in drug resistance. The resistance to erythoxystrobin has not been found in the field so far, but there have been reports of resistance in similar varieties in Europe.

Contents of the invention

In order to avoid problems such as the occurrence of resistance and the decline in drug efficacy that may be caused by the use of a single agent of erythoxystrobin, the invention discloses a bactericidal composition containing erythoxystrobin and thiocarbamate, and the preparation of the composition and applications.

Chemical name of erythoxystrobin: 3-methoxy-2-[2-((((1-methyl-3-(4-chlorophenyl)-2-propenylidene)amino)oxy)-methyl ) phenyl] methyl acrylate, the structural formula is as follows:

Chinese common name: erythoxystrobin Molecular formula: C ₂₂ H ₂₂ CINO ₄ Molecular weight: 399.87

Thiocarbamate bactericides of the present invention are mainly selected from:

Mancozeb Chemical name: Multi-coordination compound of manganese ethylene bisdithiocarbamate and zinc salt;

Maneb Chemical Name: Manganese Ethylene Bis Dithiocarbamate;

Zinc chemical name: Ethylene bis(zinc dithiocarbamate);

Zinc Propylene Chemical name: zinc propenyl bisdithiocarbamate;

Ammonium dysonium Chemical name: ammonium propenyl bisdithiocarbamate;

Dyson salt Chemical name: Ethylene bis (zinc dithiocarbamate) metal coordination compound;

Thiram chemical name: Tetramethylthiuram disulfide;

Phametium Chemical Name: N, N Dimethyl Ammonium Dithiocarbamate or

Zinc Zirconia Chemical Name: Bis(dimethyldithiocarbamate) zinc.

The bactericidal composition disclosed by the present invention contains erythoxystrobin and any thiocarbamate bactericide as active components. The bactericidal composition can also contain two or more thiocarbamate bactericides, and the object of the present invention can also be achieved.

It has been found that the mixed use of erythoxystrobin and thioamino acid salt has obvious synergistic effect, significantly improves the control effect on crop diseases, and can expand the bactericidal spectrum and delay the occurrence of drug resistance of pathogens. Ethoxystrobin and thioamino acid salts have different structure types and different mechanisms of action. The combination of the two can delay the emergence and development of drug resistance of pathogens to a certain extent, and at the same time reduce the cost of use.

In the fungicidal composition proposed by the present invention, the weight-number ratio of erythoxystrobin and thiocarbamate based on the active component is 1:100 to 100:1; a more suitable ratio is 1:20 to 20:1 .

The active ingredient in the composition of the present invention is 0.5% to 95% of the total weight. The amount of active ingredient contained in the compositions of the present invention will depend upon the rate of application of the compounds when used alone, as well as on the ratio of one compound to the other and the degree of synergistic effect.

The composition of the present invention also comprises a carrier, and contains at least two kinds of carriers. The carrier can be a solid or a liquid, including materials that are normally gaseous but liquid when compressed, and any carrier commonly used in formulating fungicide compositions can be used. The product made of the composition and the carrier is safe to be applied in the treatment place, such as farmland, orchard or warehouse, and is easy to store, transport or load and unload. The compositions of the present invention can be formulated as suspensions, (aqueous) emulsions, wettable powders, (aqueous dispersible) granules, solutions and powders contained in polymeric capsules, such as natural or synthetic formulations impregnated with active substances. material or carrier.

These formulations can be prepared by conventional methods. For example, the active substance is mixed with a liquid solvent and/or a solid carrier, while adding surfactants such as dispersants, stabilizers, wetting agents, and also binders, defoamers, and oxidizing agents. Agricultural compositions are usually formulated into various formulations, which are diluted before use by users or used directly. A small amount of surfactant carrier is present in the formulation to facilitate dilution. Thus, at least one carrier in the compositions of the present invention is a surfactant.

The present invention also includes the preparation method of the above-mentioned bactericidal composition. If water is used as diluent, organic solvents can also be used as cosolvents or stabilizers and antifreezes. Suitable organic solvents include aromatics such as benzene, xylene, toluene, alkylbenzenes, alkylnaphthalenes, and chlorinated aromatics; chlorinated aliphatics such as chlorobenzene, vinyl chloride, trichloroethane, dichloromethane, Chloroform, carbon tetrachloride and polychloroethanes; aliphatic hydrocarbons such as petroleum distillates, cyclohexane, light mineral oil, paraffin and coal; however, polar solvents, i.e. alcohols such as isopropyl Alcohols, butanol, ethylene glycol, propylene glycol, glycerol, sorbitol, benzyl alcohol, furfuryl alcohol, and cyclohexanol, and their ethers and esters; ketones, such as acetone, methyl ethyl ketone, methyl isobutyl ketone, cyclic hexanone, butyrolactone, and dimethylformamide, dimethyl sulfoxide, and N-methyl-pyrrolidone; also vegetable oils and methyl cellolysate. Also, mixtures of different liquids are suitable.

Surfactants can be emulsifiers, dispersants or wetting agents; can be nonionic or ionic. Examples of suitable surfactants include sodium or calcium salts of polyacrylic acid and lignosulfonic acid; polycondensation of fatty acids or fatty amines or amides with at least 12 carbon atoms in the molecule with ethylene oxide and/or propylene oxide Products; fatty acid esters of glycerol, 1-lauryl alcohol, 1-tetradecyl alcohol, sorbitol, sucrose or pentaerythritol; and their polycondensation products with ethylene oxide and/or propylene oxide; polycondensation products thereof sulphates or sulphonates; alkali metal or alkaline earth metal salts, preferably sodium salts, of sulfuric or sulphonic acids containing at least 10 carbon atoms in the molecule, for example, sodium lauryl sulphate, secondary alkyl sulphate Sodium, sodium salts of sulfonated castor oil, and sodium alkaryl sulfonates, such as sodium dodecylbenzenesulfonate; and polymers of ethylene oxide and copolymers of ethylene oxide and propylene oxide. In particular, the following substances can be used as emulsifiers: nonionic emulsifiers, such as polyoxyethylene fatty acid esters, polyoxyethylene fatty alcohol ethers, polyoxyethylene fatty ammonia, specific examples such as ethoxylated castor oil, polyoxyethylene ( n ₂₀ ) phenylethyl phenolic ether oleate, alkyl aryl polyoxyethylene polyoxypropylene ether, alkyl aryl formaldehyde resin polyoxyethylene ether, oleic acid calcium isothioate, tristyryl phenolic polyoxyethylene ether Oxyethylene (n ₂₀ ) ether phosphorylated triethanolamine salt, diphenylethylphenolic polyoxyethylene (n18) ether formaldehyde condensate, diphenylphenolic polyoxyethylene (n ₁₈ ) polyoxypropylene (n ₂₀ ) ether and anionic emulsifiers; or directly use commercially available emulsifiers: Nongru 0201B, Nongru 0203B, Nongru 100 ^# , Nongru 500 ^# , Nongru 600 ^# , Nongru 600-2 ^# , Nongru 1601, Nongru 2201, agricultural milk NP-10, agricultural milk NP-15, agricultural milk 507 ^# , agricultural milk OX-635, agricultural milk OX-622, agricultural milk OX-653, agricultural milk OX-667, agricultural milk CS-7, Ning Milk 36 ^# . In particular the following substances can be used as dispersants: sodium lignosulfonate, pull-off powder, calcium lignosulfonate, methylnaphthalenesulfonic acid formaldehyde condensate, naphthalenesulfonic acid formaldehyde condensate, sodium methylenenaphthalenesulfonate, Sodium oleic acid methyl amino ethyl sulfonate, epoxy polyether, p-tert-butyl ether, dibutyl naphthalene sulfonic acid formaldehyde condensate, phosphates such as sodium hexametaphosphate, alkylphenol polyoxyethylene phosphate, Alkylphenol polyoxyethylene ether formaldehyde condensate sulfate, N-methyl-fatty acyl-sodium taurate alkylphenol polyoxyethylene ether formaldehyde condensate, aralkylphenol polyoxyethylene ether phosphate alkylphenol Polyoxyethylene ether, castor oil ethylene oxide adduct, ethylene oxide-propylene oxide block copolymer alkylphenol polyoxyethylene ether formaldehyde condensate, alkylphenol polyoxyethylene polyoxypropylene ether and formaldehyde base cellulose. In particular the following substances can be used as wetting agents: sodium lauryl sulfate, sodium alkanol polyoxyethylene ether sulfate, octylphenol polyoxyethylene ether sulfate, alkylphenol polyoxyethylene ether formaldehyde condensate sulfuric acid Salt, Sodium Alkyl Sulfonate, Sodium Dodecyl Benzene Sulfonate, Sodium Alkyl Naphthalene Sulfonate, Alkyl Succinate Sulfonate, Sodium Laureth Sulfonate, Alkylamidotaurine Salt, fatty alcohol polyoxyethylene ether, alkylphenol polyoxyethylene ether, polyoxyethylene polyoxypropylene ether block copolymer, sorbitan fatty acid ester polyoxyethylene ether, etc.

Binders, which can be synthetic such as carbonyl alcohol, polyvinyl alcohol or polyvinyl acetate or natural water-soluble polymers such as xanthan gum, gelatin, gum arabic, polyvinylpyrrolidone, magnesium aluminum silicate, polyethylene Alcohol, polyethylene glycol, phenolic resin, shellac, carboxymethyl cellulose and sodium alginate, etc., are added to the preparation in the form of powder, granule or latex.

The defoaming agents are: foam enemies, silicones, C _8-10 fatty alcohols, phosphate esters, C _10-20 saturated fatty acids (such as capric acid) and amides.

Oxidants are: potassium chlorate, sodium chlorate, potassium perchlorate, sodium nitrate, potassium nitrate, potassium permanganate, etc.

Flame retardants are: ammonium chloride, magnesium oxide, bentonite, white carbon black, diatomaceous earth, zinc oxide, etc.

The formulation may contain color enhancers such as inorganic pigments iron oxide, titanium oxide or Prussian blue; organic dyes such as alizaline, azo dyes, metal phthalocyanines or triphenylmethane dyes.

Suitable solid carriers include natural or synthetic clays and silicates such as natural silica and diatomaceous earth; magnesium silicates such as talc; aluminum magnesium silicates such as attapulgite; aluminum silicates such as kaolinite, kaolin; Black; calcium carbonate, light calcium carbonate; calcium sulfate; limestone; sodium sulfate; ammonium salts such as ammonium sulfate, hexamethylenediamine; synthetic hydrated silica and synthetic calcium or aluminum silicates; elements such as carbon and sulfur ; natural and synthetic resins such as benzofuran resins, polyvinyl chloride, and styrene polymers and copolymers; solid polychlorinated phenols; bitumen; paraffin waxes; solid fertilizers such as superphosphates. Solid carriers particularly suitable for use in powders include naturally occurring rock powders, chalk, quartz, clay, montmorillonite, silica, diatomaceous earth, pumice, gypsum, talc, bentonite, kaolin, china clay, and synthetic ground minerals. Substances such as finely divided silicic acid or alumina; suitable particulate carriers include crushed and graded natural rocks such as calcite, marble, pumice, sepiolite and dolomite and synthetic granules made of organic and inorganic powders. In addition, particulate carriers can be prepared from organic materials such as wood chips, peanut shells, coconut shells, corn cobs, corn starch, soluble starches, and dried tobacco rods.

According to the type of formulation of the composition, solid formulations contain 5% to 85% by weight of active substance, preferably 10-80%; liquid formulations contain 1-70% by weight of active substance; suspension formulations contain by weight 10-60% active substance. All percentages below are percentages by weight.

Wettable powders generally contain 10-85% by weight of active ingredients, in addition to solid inert carriers, usually 3-10% by weight of dispersants and, if desired, 0-10% by weight of stabilizers and/or other additives such as penetrants or adhesives. (Water-dispersible) granules are usually prepared as 10-100 international standard mesh (1.676-0.152mm) granules and can be prepared by agglomeration or impregnation methods. Granules generally contain 0.5-75% by weight of active ingredient and 0-10% by weight of additives, such as stabilizers, surfactants, slow-release regulators and binders. Suspension concentrates usually need to be stirred to obtain a stable non-sedimentary flowable product, which usually contains 10-75% active ingredient, 0.5-15% dispersant, 0.1-10% thixotropic agent, 0-10% Other additives, such as defoamers, corrosion inhibitors, stabilizers, penetrants and adhesives, water or organic liquids, where the active components are essentially insoluble. Certain organic solids or inorganic salts may be dissolved in the formulation to help prevent sedimentation or act as antifreeze agents. Aqueous dispersions and emulsions, such as compositions obtained by diluting the wettable powders or concentrates of the invention with water, are also within the scope of the invention. The aforementioned emulsions may be of the water-in-oil or oil-in-water type and may have a thick paste-like consistency.

The products described in the present invention may be provided as finished formulations, ie the ingredients of the composition have been mixed, but the components of the composition may also be provided as separate formulations which are mixed directly in the barrel (tank) prior to use. The concentrates of the present invention are generally mixed with water to obtain the desired concentration of active substance.

The composition of the present invention can be used to control the diseases of various plants caused by pathogenic fungi, such as cereals, wheat, rice, grapes, strawberries, cucumbers, zucchini, peppers, sweet peppers, eggplants, tomatoes, kidney beans, cowpeas, leeks, lettuce, Cabbage, sunflower, lychee, tobacco, rubber and some flowers, Chinese medicinal materials, lawn, etc. The application site of the fungicide composition of the present invention is farmland, orchard or warehouse.

The composition of the present invention can also be used in combination with other compounds having herbicidal, insecticidal or bactericidal properties, especially protective fungicides, and can also be used in combination with nematicides, protective agents, growth regulators, plant nutrients or soil conditioners .

The present invention also includes a method for killing fungi on site, applying the composition of the present invention to the crops and/or fruits and the place where they are grown or stored before or after the crops and/or fruits are susceptible to disease. The compositions of the present invention can be applied in the usual manner, such as pouring, spraying, spraying, dusting, spreading. The application rates of the present invention vary with weather conditions or crop conditions. The duration of the protective effect is usually related to the content of the individual compounds in the composition, but also to external factors, such as climate, which can be mitigated by using appropriate formulations.

The composition of the present invention has the following advantages: one, the composition shows excellent synergistic effect within a certain proportioning range, and the composition after mixing obviously improves the bactericidal effect compared with its single agent, thereby reducing the dosage , while reducing the cost of pesticides for farmers, it also reduces the degree of impact on the environment. The second is to expand the bactericidal spectrum, and the characteristics of the agents are also highly complementary. One agent can prevent and treat a variety of crop diseases at the same time, providing an extremely convenient and effective means of use, and it is effective for grains, vegetables, fruits, lawns and tropical crops. Downy mildew, blight, anthracnose, rice blast, powdery mildew, late blight, scab, brown spot, scab, sheath blight, leaf spot, sclerotinia, etc. prevention effect. The third is that the structure of the composition has a large difference among varieties, and there is no cross-resistance, and the occurrence and development of single-dose resistance can be effectively delayed after mixing.

Detailed ways

The following examples further specifically illustrate the present invention, but the present invention is by no means limited to these examples. All proportions in the preparation are weight percentages; the treatment doses of biologically active parts are all effective contents.

Composition preparation and biological activity example

1. Preparation of wettable powder

According to the requirements of the formula, the original drug, various additives and fillers are fully mixed, and the processed product is obtained after being pulverized by an ultra-fine pulverizer. Such as example 1～5 formula

Embodiment 1 (20% wettable powder)

Ethoxystrobin 4%, maneb 16%, sodium lauryl sulfate 2%, carboxymethyl cellulose 3%, white carbon black 10%, calcium lignosulfonate 10%, light calcium carbonate supplemented to 100%.

Embodiment 2 (30% wettable powder)

25% of erythoxystrobin, 5% of propineb, 2% of sodium lauryl sulfate, 10% of white carbon black, 10% of sodium lignosulfonate, and 100% of light calcium carbonate.

Embodiment 3 (40% wettable powder)

Ethoxystrobin 5%, mancozeb 35%, sodium dodecylbenzene sulfonate 1%, white carbon black 10%, sodium lignosulfonate 10%, and light calcium carbonate supplemented to 100%.

Embodiment 4 (50% wettable powder)

Ethoxystrobin 5%, thiram 45%, sodium dodecylbenzene sulfonate 2%, white carbon black 10%, naphthol sulfonic acid formaldehyde condensate sodium salt 10%, light calcium carbonate supplemented to 100%.

Embodiment 5 (63% wettable powder)

Ethoxystrobin 3%, Zinc 60%, Sodium Lauryl Sulfate 1.5%, White Carbon Black 5%, Sodium Lignosulfonate 8%, Light Calcium Carbonate supplemented to 100%.

2. Preparation of water emulsion

Add the original drug, solvent, emulsifier and co-emulsifier together to dissolve into a homogeneous oil phase. Mix water, antifreeze, etc. together to form a homogeneous water phase. Under high-speed stirring, add the water phase to the oil phase or add the oil phase to the water phase to form a water emulsion with good dispersibility. Such as example 6～9 formula.

Embodiment 6 (10% water emulsion)

Ethoxystrobin 1%, Dysonamide 9%, Polyvinyl Alcohol 0.8%, Sorbitan Fatty Acid Ester Polyoxyethylene Ether 5%, Alkyl-Diethylene Glycol Ether-Sodium Sulfonate 2.5%, Agricultural Milk 2201 2%, Dimethylformamide 8%, Ethylene Glycol 5%, Water to make up to 100%.

Embodiment 7 (15% water emulsion)

Enoxstrobin 1%, mancozeb 14%, polyvinyl alcohol 0.9%, alkylaryl polyoxyethylene polyoxypropylene ether 3.5%, agricultural milk 2201 5%, dimethylformamide 12%, ethylene glycol Alcohol 5%, water to make up to 100%.

Embodiment 8 (25% water emulsion)

Ethoxystrobin 5%, Zinc 25%, Polyvinyl Alcohol 1.2%, Tristyrylphenol + Ethylene Oxide, Phosphorylated, Triethanolamine Neutralized 9.5%, Alkyl-Diethylene Glycol Ether-Sulfonic Acid Sodium 3.5%, Nongru 2201 13%, DMF 8%, ethylene glycol 5%, water to make up to 100%.

Embodiment 9 (31.5% water emulsion)

Ethoxystrobin 30%, Dysamide 1.5%, Polyvinyl Alcohol 1.8%, Sorbitan Fatty Acid Ester Polyoxyethylene Ether 10%, Alkyl-Diethylene Glycol Ether-Sodium Sulfonate 3.5%, Agricultural Milk 2201 2%, Dimethylformamide 12%, Ethylene Glycol 5%, Water to make up to 100%.

3. Preparation of water dispersible granules

Mix and pulverize the original drug, powdery carrier, wetting and spreading agent, binder, etc., add water and knead, then add to a granulator equipped with a certain size screen for granulation. Then dry and sieve (according to the range of the sieve) to obtain granular products. Such as example 10～11 formula.

Embodiment 10 (50% water dispersible granule)

Enoxstrobin 6.25%, thiram 43.75%, sodium methylnaphthalenesulfonate formaldehyde condensate 10%, epoxy polyether 5%, soluble starch 5%, polyvinylpyrrolidone 5%, attapulgite to 100%.

Embodiment 11 (60% water dispersible granule)

Enoxostrobin 10%, mancozeb 50%, sodium methylene naphthalene sulfonate 10%, sodium dodecylbenzene sulfonate 15%, polyvinylpyrrolidone 5%, attapulgite to 100%.

4. Preparation of suspending agent

According to the requirements of the formula, with water as the medium, add the original drug, dispersant, suspending agent and antifreeze into the sand mill, and grind to make a suspension. Such as example 12～14 formula.

Embodiment 12 (10% suspending agent)

Ethoxystrobin 1%, Dysenil 9%, Sodium methylnaphthalene sulfonate formaldehyde condensate 5.5%, White carbon black 5%, Magnesium aluminum silicate 2.0%, Ethylene glycol 10%, Tributyl phosphate a little, Diatomaceous earth 5%, water make up to 100%.

Embodiment 13 (25% suspending agent)

5% erythoxystrobin, 20% propeneb, 5% calcium lignosulfonate, 2% white carbon black, 10% urea, a little tributyl phosphate, and make up to 100% with water.

Embodiment 14 (35% suspending agent)

Enoxstrobin 5%, mancozeb 30%, sodium methylnaphthalene sulfonate formaldehyde condensate 2.5%, bentonite 1.0%, agricultural milk 16013%, glycerol 8%, tributyl phosphate a little, water to make up to 100%.

5. Biological activity

The grading standards for field efficacy tests follow the grading standards and grading records of the "Pesticide Field Test Guidelines" issued by the Institute for Drug Control of the Ministry of Agriculture, and the control effect is calculated by the disease index.

Embodiment 15 antibacterial activity (potato late blight)

The antibacterial effect of maneb, enostrostrobin and the preparation of Example 1 on potato late blight was determined indoors by the method of toxic medium. Test method: Add quantitative chemicals to PDA medium, inoculate P. infestans de Bary after cooling, culture at 24°C without light after inoculation, and conduct results investigation after culturing for 96 hours. The test results are as follows:

Embodiment 16 antibacterial activity (maize spot disease)

The bacteriostasis effect of erythoxystrobin, propineb and the preparation of Example 2 on corn leaf spot was determined indoors by the method of toxic medium. Test method: add quantitative medicines to PDA medium respectively, inoculate corn small spot (Bipolarismayghi) after cooling, culture at 24°C without light after inoculation, and cultivate for 96 hours to investigate the results. The test results are as follows:

Embodiment 17 antibacterial activity (rice bakanae disease)

The bacteriostasis effect of erythoxystrobin, dythycin and the preparation of Example 6 on rice bakanae disease was determined indoors by the method of toxic medium. Test method: Add quantitative chemicals to PDA medium respectively, inoculate rice bakanae (Fusarium moniliforera) after cooling, culture at 24°C without light after inoculation, and cultivate for 96 hours to investigate the results. The test results are as follows:

Embodiment 18 antibacterial activity (peanut brown spot)

The bacteriostasis effect of erythoxystrobin, propineb and the preparation of Example 13 on peanut brown spot was determined indoors using a toxic medium method. Test method: Add quantitative chemicals to PDA medium, inoculate peanut brown spot fungus (Cercospora arachidicola Hori) after cooling, culture at 24°C without light after inoculation, and cultivate for 96 hours to investigate the results. The test results are as follows:

Embodiment 19 disease control effect (cucumber downy mildew)

In the room, the plate method was used to determine the antibacterial effect of erynostrobin, mancozeb and Example 5 on cucumber downy mildew. Test method: Put the cucumber leaves in a petri dish for moisturizing treatment, and spray the pesticides according to the designed dosage, inoculate the pathogenic bacteria of cucumber downy mildew (Psudoperonospora cubensis) after 24 hours, and culture it in an artificial climate room after inoculation, and carry out 6 days later. Result survey. The test results are as follows:

Embodiment 20 disease control effect (cucumber powdery mildew)

Cucumber seedlings were planted in pots in the greenhouse, and the control effects of enotristrobin, mancozeb and the preparation of Example 7 on cucumber powdery mildew were determined. Cucumber variety: Shandong Mici, pathogen: cucumber powdery mildew (Erysiphe cihporacearum); when the cucumber grows to 3 to 4 leaves, the growth is uniform, and the foliar spray is carried out on the crop sprayer according to the designed dose, and the pathogen is inoculated 24 hours later. After inoculation, the results were investigated after 7 days of moist chamber culture in a humid chamber. The test results are as follows:

Embodiment 21 disease control effect (cucumber scab)

Cucumber seedlings were planted in pots in the greenhouse, and the control effects of enotristrobin, thiram and the preparation of Example 10 on cucumber scab were determined. Cucumber variety: Shandong Mici, pathogen: Cucumber black disease (Cladosporium cucumerium); when the cucumber grows to 3 to 4 leaves, the growth is uniform, and the foliar spray is carried out on the crop sprayer according to the designed dose, and the inoculation is done 24 hours later. Pathogens were cultured in a wet room for 7 days after inoculation, and the results were investigated. The test results are as follows:

Embodiment 22 disease control effect (grape downy mildew)

Grape seedlings were cut and cut in pots in the greenhouse, and the control effects of enotristrobin, zinc and the preparation of Example 8 on grape downy mildew were determined. Grape variety: Jufeng, Pathogen: Grape downy mildew (Plasmopara viticola): When the cutting grape seedlings in the greenhouse grow to 3 to 4 leaves, select 2 leaves that grow uniformly, and spray the leaves on the crop sprayer according to the designed dosage. Spray treatment, inoculation of pathogenic bacteria 24 hours later, and result investigation after 7 days of moisturizing culture after inoculation. The test results are as follows:

Embodiment 23 field plot control effect (apple spot defoliation disease)

The control effects of erythoxystrobin, propineb and the preparation of Example 9 on apple leaf spot were determined in the field. Apple variety: Xinhongxing, pathogen: Alterlaria mali; apply pesticides when lesions first appear in the apple orchard, spray 3 times with an interval of 7 days, and investigate the control effect 15 days after the 5th application. The test results are as follows:

Embodiment 24 field district control effect (tomato late blight)

The control effect of erythoxystrobin, zinc and the preparation of Example 3 on tomato late blight was determined in a solar greenhouse. Tomato variety: Maofen 402, pathogen: tomato late blight (Phytophthora infestans); in late March in spring, when the lesions first appeared in the field, spray 4 times with an interval of 7 days, 7 days after the fourth application Investigate effectiveness. The test results are as follows:

Embodiment 25 field plot control effect (peanut leaf spot)

The prevention and control effects of etoxystrobin, mancozeb and the preparation of Example 14 on peanut leaf spot were measured in the field. Peanut variety: Nonghua No. 26, pathogen: Cercospora personata. The pesticide was applied when the lesions first appeared in the peanut field, sprayed 3 times with an interval of 7 days, and the control effect was investigated 15 days after the third application . The test results are as follows:

Example 26 Control effect of field plots (rice bakanae disease)

The control effect of erythoxystrobin, zinc and the preparation of Example 12 on rice bakanae disease was determined in a solar greenhouse. Rice variety: Liaogeng No. 5, pathogen: rice bakanae (Fusarium moniliforera), chemical treatment method is soaking seeds, and the concentration of soaking seeds is 800, 400, 200, 100ug/ml. Investigate the control effect before rice transplanting. The test results are as follows:

Claims (9)

1. A bactericidal composition, containing the fungicide enoxastystrobin and any thiocarbamate fungicide; the weight and number ratio of enoxastrobin and thiocarbamate based on the active components is 1 :100 to 100:1. 2. The fungicidal composition according to claim 1, characterized in that the weight-number ratio of erythoxystrobin and thiocarbamate based on the active components is 1:20 to 20:1. 3. The bactericidal composition according to claim 1 or 2, characterized in that: the thiocarbamate bactericide is selected from mancozeb, maneb, zinc, propineb, Sennium, dyson salt, thiram, thiram, or thiram zinc. 4. The bactericidal composition according to claim 3, characterized in that: the thiocarbamate bactericide is selected from mancozeb, maneb, zinc, propineb, and zinc Or Familiad. 5. The fungicidal composition according to claim 1 or 2, characterized in that the active ingredient in the composition has a weight percentage of 0.5-95%. 6. The fungicidal composition according to claim 1, characterized in that the composition contains at least two carriers, at least one of which is a surfactant. 7. The fungicidal composition according to claim 1, characterized in that: the composition can be formulated into a suspension, an emulsion in water, a wettable powder or a water-dispersible granule. 8. Use of the fungicidal composition according to claim 1 for controlling plant diseases caused by pathogenic fungi. 9. A method for killing fungi on the spot, characterized in that: before or after the crops and/or fruits are susceptible to disease, apply the fungicidal agent according to claim 1 or 7 to the crops and/or fruits and the places where they are grown or stored combination.