CN1562143A - 一种治疗复发性口腔溃疡及疮疹性口腔炎的中药贴片的制备方法 - Google Patents
一种治疗复发性口腔溃疡及疮疹性口腔炎的中药贴片的制备方法 Download PDFInfo
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Abstract
本发明公开了一种治疗复发性口腔溃疡及疮疹性口腔炎的中药贴片的制备方法。它按处方比例称取珍珠、人工牛黄、青黛、冰片、滑石，单独粉碎后，分别过筛备用；将各药材细粉混匀，过筛，加入卡波姆和其它辅料，充分混匀，压片，包衣，制成单面释药包衣贴片。将其开发成单面释药的口腔贴片，直接粘附于口腔溃疡面上，既可保持与溃疡粘膜较长的接触时间，充分发挥药效，又可避免散剂和嗽口液对病人带来的不适，大大提高了病人的依从性。
Description
技术领域
本发明涉及一种治疗复发性口腔溃疡及疮疹性口腔炎的中药贴片的制备方法。
背景技术
复发性口腔溃疡、疮疹性口腔炎、白塞氏病、扁平苔癣等是常见病、多发病，也是迁延不愈的疑难病，女性发病率高于男性，其确切的发病原因目前尚不完全清楚，可能与下列因素有关：①家族遗传；②不注意口腔卫生，口腔粘膜长期受到病毒或细菌感染；③情志不遂，精神压力大，焦虑失眠等；④饮食不节或偏食，导致体内维生素、微量元素不足或失衡；⑤长期过量饮酒或吸烟。中医认为，本病是由于外感时邪，七情内伤，素体虚弱，致使肝郁气滞，郁热化火，阴虚火旺，湿热不化，血脉瘀阻而引发的。最近，医学界经过临床与免疫学研究，认为其病原为二种病毒感染，这二种病毒分别为人类巨细胞病毒和EB病毒(非洲淋巴细胞瘤病毒，属于一种疱疹病毒)，前者潜伏在血液的T淋巴球中，后者潜伏在血液的B淋巴球中，一旦感冒、体虚、情绪波动或免疫力低下时，病毒就会发作。
上述疾病均好发于颊、舌、腭、牙龈、唇内侧等部位。由于口腔粘膜久溃不愈，加上受到说话、咀嚼、食物和烟酒的刺激，易造成癌前病损，从而易引发癌变。
对于复发性口腔溃疡、疮疹性口腔炎、白塞氏病、扁平苔癣，除注意饮食调理，克服不良生活习惯外，常用的治疗方法有：
(1)西药治疗用糖皮质激素、强的松等激素类软膏局部涂擦，以促使溃疡愈合；用10％硝酸银或硫酸铜烧灼治疗；肌注丙种球蛋白、胎盘蛋白、转移因子；补充维生素；使用呋喃唑酮、金霉素、左旋咪唑、洗必泰、可罗宁等抗生素。
(2)中药治疗用冰硼散、锡类散、养阴生肌散、珍黛散等直接吹敷患处；用金银花、甘草、野菊花、地肤子、苦参等煎汤嗽口；内服六神丸等制剂。
虽然复发性口腔溃疡、疮疹性口腔炎、白塞氏病、扁平苔癣的病因和治疗研究已取得了较大进步，但目前临床上尚无系统的治疗方法和根治药物。西药往往是治标不治本，难治愈，易复发，同时易产生抗药性，有些局部使用的西药对正常组织也有损伤作用，如硝酸银等，少数西药可能还有致癌的潜在危险。与西药相比，按中医理论组方的中药复方制剂则有许多优势，如所含活性成分较多，具有多方面的药理作用，可广泛用于各种原因所引起的口腔溃疡。另外，中药对病毒的综合抑制作用要远远好于西药，这已在学术界形成共识。因此，在治疗上述疾病方面，开发疗效确切，剂型新颖的纯中药制剂具有广阔的市场前景。然而，纵观目前临床上所使用的治疗上述疾病的中药制剂，品种较多、疗效也较好的是散剂和漱口液，但散剂或漱口液因有强烈的苦味和不适，病人的依从性很差，且使用不太方便。另外，散剂吹敷患处后，药物在溃疡面上滞留时间极短，生物利用度较低，难以发挥持久的药效，需反复多次给药。
发明内容
为了克服目前用于复发性口腔溃疡及疮疹性口腔炎的诸多西药之缺陷，又能弥补同类中药之不足而提供一种治疗复发性口腔溃疡及疮疹性口腔炎的中药贴片的制备方法。
本发明的技术方案为：按处方比例称取珍珠、人工牛黄、青黛、冰片、滑石，单独粉碎后，分别过筛备用；将各药材细粉混匀，过筛，加入辅料，充分混匀，压片，包衣，制成单面释药包衣贴片。
珍珠水飞或超微粉碎成极细粉；人工牛黄、冰片、滑石粉碎成能过6号筛的细粉，辅料中设有卡波姆934，包衣物料是聚丙烯酸树脂III。
本发明压片时所用辅料为卡波姆934、羧甲基纤维素钠、微粉硅胶和硬脂酸镁；上述各辅料的用量为：按所有药物占20％～40％、卡波姆934占40％～60％、羧甲基纤维素钠占10％～30％的比例将这三部分混匀，按物料总量计微粉硅胶占1％～5％、硬脂酸镁占0.5％～2％。
本发明选择临床有效中药复方制剂，将其开发成单面释药的口腔贴片，直接粘附于口腔溃疡面上，既可保持与溃疡粘膜较长的接触时间，充分发挥药效，又可避免散剂和嗽口液对病人带来的不适，大大提高了病人的依从性。
具体实施方式
处方组成：珍珠、人工牛黄、青黛、冰片、滑石
制备方法：按处方比例称取各药材，其中珍珠水飞或超微粉碎成极细粉。人工牛黄、冰片、滑石单独粉碎后，过6号筛备用。将各药材细粉混匀，过6号筛，按所有药物占20％～40％、卡波姆934占40％～60％、羧甲基纤维素钠占10％～30％的比例将这三部分混匀，再加入物料总量1％～5％的微粉硅胶和0.5％～2％的硬脂酸镁，充分混匀，压片，用聚丙烯酸树脂III并加入少量核黄素进行单面包衣。
Claims (5)
1、一种治疗复发性口腔溃疡及疮疹性口腔炎的中药贴片的制备方法：按处方比例称取珍珠、人工牛黄、青黛、冰片、滑石，单独粉碎后，分别过筛备用；将各药材细粉混匀，过筛，加入辅料，充分混匀，压片，包衣，制成单面释药包衣贴片。
2、根据权利要求1所述的制备方法，其特征是辅料中设有卡波姆934。
3、根据权利要求1所述的制备方法，其特征是珍珠水飞或超微粉碎成极细粉；人工牛黄、冰片、滑石粉碎成能过6号筛的细粉。
4、根据权利要求1所述的制备方法，其特征是包衣物料是聚丙烯酸树脂m。
5、根据权利要求1所述的制备方法，其特征是压片时所用辅料为卡波姆934、羧甲基纤维素钠、微粉硅胶和硬脂酸镁；上述各辅料的用量为：按所有药物占20％～40％、卡波姆934占40％～60％、羧甲基纤维素钠占10％～30％的比例将这三部分混匀，按物料总量计微粉硅胶占1％～5％、硬脂酸镁占0.5％～2％。
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102000282A (zh) * | 2010-11-11 | 2011-04-06 | 姚源璋 | 一种治疗复发性口腔溃疡纯中药贴片及其制备方法 |
| CN104258126A (zh) * | 2014-09-23 | 2015-01-07 | 唐国萍 | 一种治疗复发性阿弗他溃疡的药物组合物 |
| CN104257863A (zh) * | 2014-10-24 | 2015-01-07 | 曹元智 | 一种治疗复发性口腔炎的中药制剂 |
| CN104771490A (zh) * | 2015-04-01 | 2015-07-15 | 杨志峰 | 一种治疗复发性口腔溃疡的中药组合物 |
| CN105381003A (zh) * | 2015-11-19 | 2016-03-09 | 哈尔滨圣吉药业股份有限公司 | 一种珍黛口含片及其制备方法 |
| CN105497068A (zh) * | 2015-12-25 | 2016-04-20 | 张超 | 人工牛黄甲硝唑口腔贴片及其制备方法 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102000282A (zh) * | 2010-11-11 | 2011-04-06 | 姚源璋 | 一种治疗复发性口腔溃疡纯中药贴片及其制备方法 |
| CN102000282B (zh) * | 2010-11-11 | 2013-01-23 | 姚源璋 | 一种治疗复发性口腔溃疡纯中药贴片及其制备方法 |
| CN104258126A (zh) * | 2014-09-23 | 2015-01-07 | 唐国萍 | 一种治疗复发性阿弗他溃疡的药物组合物 |
| CN104257863A (zh) * | 2014-10-24 | 2015-01-07 | 曹元智 | 一种治疗复发性口腔炎的中药制剂 |
| CN104771490A (zh) * | 2015-04-01 | 2015-07-15 | 杨志峰 | 一种治疗复发性口腔溃疡的中药组合物 |
| CN105381003A (zh) * | 2015-11-19 | 2016-03-09 | 哈尔滨圣吉药业股份有限公司 | 一种珍黛口含片及其制备方法 |
| CN105497068A (zh) * | 2015-12-25 | 2016-04-20 | 张超 | 人工牛黄甲硝唑口腔贴片及其制备方法 |
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