CN1403129A - Chinese medicine prepn for stopping drug addiction - Google Patents
Chinese medicine prepn for stopping drug addiction Download PDFInfo
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- CN1403129A CN1403129A CN02133344A CN02133344A CN1403129A CN 1403129 A CN1403129 A CN 1403129A CN 02133344 A CN02133344 A CN 02133344A CN 02133344 A CN02133344 A CN 02133344A CN 1403129 A CN1403129 A CN 1403129A
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- Prior art keywords
- chinese medicine
- reverting
- drug abuse
- medicine preparation
- aloe
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- Medicines Containing Plant Substances (AREA)
Abstract
The Chinese medicine preparation for stopping drug addiction is prepared with nine kinds of Chinese medicinal materials including fresh aloe leaf, kendir leaf, cordate houttuynia, balloonflower root, etc. as well as honey and medicinal acceptable additive. It is prepared into oral liquid capsule, chewing gum and other forms. It can reduce the harm of drug, such as heroin, cocain, marijuana, etc. effectively, raise immunity, regulate endorphin system and prevent re-taking in drug.
Description
(technical field)
The present invention relates to a kind of Chinese medicine composition that is used to quit drug abuse, particularly a kind of is the anti-Chinese medicine preparation of reverting to take drugs of quitting drug abuse raw material being used to made from Chinese medicines such as Aloe Xiao Lan green grass or young crops.
(technical background)
Drugs have become one of current the most serious global social problem.The whole world 600,000,000 people that have an appointment relate to drug abuse according to reports, and China drug addict on the regular payroll has 860,000, and most of drug addicts catch drug addiction and all can not extricate oneself, and the whole world is died from more than about 100,000 people of people of drugs every year.Drugs are to human existence and develop formation threat greatly, caused the common concern of countries in the world, and when drug-pedlar's poison was made in severe strike, drug rehabilitation was an important step in the banning drugs work.For a long time, people have carried out a large amount of explorations and research to the prohibition of drug, but the problem of reverting to take drugs is never effectively solved, cause junkie to guard against repeatly incessantly, get rid of factors such as society, family, causing a major reason of reverting to take drugs is not have a kind of effective, practical anti-medicine of reverting to take drugs can effectively eliminate because the health " positive reinforcement " that brings of drugs and " negative reinforcement " act on so far, the misery of can't the dysfunction of antagonism endorphins regulating system being brought.In recent years, world many countries all carrying out relevant aloetic research, all has clear and definite demonstration about effects such as aloetic detoxifcation, enhancing immunity in the prior art.Published by Jilin science and technology publishing house in January, 1999, the 123rd page of " the practical encyclopaedia of Aloe " book of Meng Xiangying chief editor discloses Aloe poisonous medicine had function of detoxification.Report according to some scholars' research in recent years, composition superoxides qi enzyme (the Superoxide dismutase that contains polysaccharose substance in the Aloe gel (Aloe VeraGel) and remove free radical, be called for short SOD), polysaccharide composition in the Aloe can improve body's immunological function, strengthen the huge function of biting, make the injured system recovery of exempting from service normal.The problem that prior art exists is: simple aloe preparation is not ideal enough to the harm aspect effect of human body to eliminating drugs, and simple aloe preparation is limited in the effect of enhancing human body immunity power.Chinese patent (94100905.x) disclosed " the specially good effect Chinese medicine against drug dependence preparation and the method for making of radical cure drug addiction " is made up of kinds of traditional Chinese medicines, and Aloe is the 8-20 gram in its detoxifcation is loose.Chinese patent literature (00121306.7) disclosed " a kind of anti-additive medicament and preparation method thereof " is made up of kinds of traditional Chinese medicines, and Aloe is 240 grams therein.
(summary of the invention)
The new solution that the purpose of this invention is to provide a kind of anti-Chinese medicine preparation of reverting to take drugs that is used to quit drug abuse, it can reduce effectively drugs particularly opioid such as heroin, cocaine, Fructus Cannabis etc. to the harm of human body, lower its toxicity, human body immunity improving power, readjust the disorder of endorphins regulating system function, thereby reach the anti-purpose of reverting to take drugs of drug rehabilitation.
Technical scheme of the present invention is that a kind of anti-Chinese medicine preparation of reverting to take drugs that is used to quit drug abuse is characterized in that it mainly being by following raw materials by weight preparation, Fresh leaf of aloe 50-80%, small Qinglan 1-10%, Folium Apocyni Veneti 1-10%, Herba Houttuyniae 1-10%, Radix Platycodonis 1-2%, Folium Perillae 1-2%, Ganoderma 1-2%, mouthful stilbene 1-2%, Radix Glycyrrhizae 1-2%, Mel 8-14%.The preferred weight percent of Fresh leaf of aloe is 65-75%.The preferred weight percent of small Qinglan is 2-4%.
The present invention also can contain Herba Menthae, and the Radix Ginseng of 1-10%, Radix Codonopsis or Radix Pseudostellariae also can contain preservative sodium benzoate 1%, antioxidant V-C1%, or 16 alkanols 1%.
The present invention is equipped with medicine or food acceptable additive, makes oral liquid, capsule, chewing gum, tea or confection.
The pharmacological effect of each composition is as follows in the preparation of the present invention:
Aloe: Xin Liang, body are slided, are moisturized, relieving constipation, scorching, the wet dissipation detoxifcation of reconciliation, have raise immunity, anticancer, radioprotective, antiinflammatory, protect the liver, the effect of detoxifcation, relieving constipation, increase interleukin, eliminate endotoxin, can obviously improve patient's overall health of patients.
Folium Apocyni Veneti: reduce nicotine and tar content, and tracheitis is had certain preventive and therapeutic effect (coming from People's Medical Officer Press's " smoking is with healthy "); The leukocyte increasing number proves radiation resistance and reinforced immunological effect (coming from People's Health Publisher 96.10 " national Chinese herbal medicine compilation ").
Herba Houttuyniae: the leukocyte increasing phagocytic activity, strengthen non-specific immunity (coming from above-mentioned " national Chinese herbal medicine compilation "), contained grease has bacteriostasis (coming from " Chinese medicine voluminous dictionary "); Increase interleukin, improve immunity (coming from Chengdu Traditional Chinese Medical College's " Chinese materia medica ").
Radix Platycodonis: the clinical effectiveness identical with penicillin arranged, and good to pharyngeal antiinflammatory effect than penicillin, complication is less, (coming from " Chinese Medical Journal 60:46:132 "); Contained kikyosaponin can promote the respiratory mucus secretion increasing, sharp eliminating phlegm and expelling toxin.
Radix Glycyrrhizae: have Detoxication (coming from " pharmaceutical journal " (day) 86.828.96) significantly to reduce urethane, arsenobenzene (nuisance in the tar), histamine's toxicity to cigarette alkali.
Mel: refrigerant, seasoning, detoxifcation, anticorrosion.
Xiao Lan green grass or young crops: hot flat, separate Semen Papaveris poison (Chinese medicinal herbal).
Folium Perillae: Xin Wen separates fish Eriocheir sinensis dolphin poison.
Mouth stilbene: sweet tepor, invigorating the spleen and replenishing QI.
Ganoderma: sweet flat, improve the function of exempting from service.
Herba Menthae: hot icy gas, cleaning heat and expelling wind.
Radix Ginseng: Attenuation (coming from " pharmaceutical journal " (day) 73.841.19.63).
The state-run laboratory research of the U.S. confirms that monoamine oxidase, MAO in smoker's brain (MAO) content descends 40%, and MAO can suppress the secretion of brain dopamine, and nicotine can stimulate the dopamine secretion to increase, thereby addiction.Many scholars such as NESTLER etc. studies have shown that, the sense of euphoria of junkie, dependency, withdrawal symptom, craves for phenomenon such as revert to take drugs and all with dopamine system tangible relation is arranged.Italy's scholar's research thinks that drugs and nicotine all make brain the same area---the shell activeness of " ACCUMB--ENS " nuclear between forebrain and midbrain is strengthened, all discharge dopamine, suck the effect that just can produce soon behind Nicotiana tabacum L. and the drugs and produce Lai Shouxing nicotine, suck equally opium drug such as sea cough up because of, cocaine also can very fast generation dependency.Drug abuse is an opioid to the nuisance of people's maximum, pass through receptor acting after the drug abuse, bring out human body and produce sense of euphoria, comfort, form the positive reinforcement effect, occur multiple malaise symptoms during drug rehabilitation, junkie often shows as and sheds tears, yawn, expectorant sticking and many, flurried, joint pain, tongue fur BOHUANG, faint and rapid pulse in the heart, the damp-heat in upper-JIAO syndrome, form the negative reinforcement effect, dual function makes human body produce the dependence of serious physiology and psychology.The present invention is to lead lung-heat off, the pathogenic fire purging of detoxifying, to set upright QI invigorating, remove residual poison, recover the function of endogenous opiatepeptide regulating system gradually, opiate receptor is in saturation, exogenous opium chemical compound can not be combined with opiate receptor, thereby do not produce euphoriant effect, also just eliminated the positive reinforcement effect of drugs.The present invention is by blood circulation promoting and blood stasis dispelling, and effects such as the spleen and stomach regulating and tranquilizing by nourishing the heart make the various protracted symptoms after the drug rehabilitation alleviate, eliminate, and have reduced the negative reinforcement effect.Herba Apocyni veneti, Xiao Lan green grass or young crops and Radix Glycyrrhizae all have the effect of removing opioid and other nuisance content among the present invention; Aloe, Radix Platycodonis all have relieving constipation, expectorant effect, assist toxin expelling, thereby lower the harm to junkie of opioid and other nuisance effectively.After the opium material enters human body during drug abuse, locate to assemble, distribute lonizing radiation at blood, liver, pancreas, kidney, lymph node and bone marrow etc., immunocyte around destroying, cause radiation damage, aforementioned " the practical encyclopaedia of Aloe " book is discussed for the 88th page, Aloe extract has the Antiradiation injury effect that strengthens Herba Apocyni veneti extract, illustrates that the present invention uses both simultaneously junkie is had therapeutical effect preferably; Aloe, Herba Apocyni veneti, Xiao Lan green grass or young crops and Herba Houttuyniae all have the macrophage of increasing and quantity of leucocyte among the present invention, strengthen the effect that it engulfs the antibacterial ability, Herba Houttuyniae increases white Jie's number, antibiotic, the sharp expectorant of Radix Platycodonis antiinflammatory, add the effect of Ganoderma, mouthful stilbene and Folium Perillae, greatly improve body's immunological function, the multiple components synergism than the antitoxin harmful ability of single aloe preparation, obviously strengthens the capability of resistance to radiation of body and immunocompetence effect in the present invention.By following to the mice animal experiment, prove of the present invention nontoxic and can remove the toxicity that opioid produces human body effectively, thereby safeguard the healthy of junkie, reach the purpose of drug rehabilitation.
Experiment one
Get 30 of qualified mices, body weight is 20 grams ± 2 grams, is divided into high dose group, low dose group and matched group at random, 10 every group, and the every day of administration respectively, medicine is a preparation of the present invention, high dose group administration 0.4ml//day, 1ml contains the 1g dose; Low dose group administration 0.4ml//day, 1ml contains the 0.5mg dose, calculate with mice 20 gram body weight, dosage is equivalent to 15 times and 5 times of human dosage respectively, the matched group feedwater, be administered once every day, successive administration 20 days, after time administration 1 hour, each treated animal stomach is irritated and is only contained opioid liquid medicine 0.4ml/, observed 48 hours, and the results are shown in Table: 10 0 10 of 10 37＞0.05 matched groups of group quantity survival number death toll 10 55＜0.05 low dose group of P high dose group
Result of the test shows, take drugs and began administration in preceding 20 days, all take drugs for 3 groups with same dosage, after the drug abuse, high dose group mice survival rate is 50%, and the low dose group survival rate is 30%, and not administration group survival rate is 0, proof the present invention truly has and removes the toxic effect of opium material, and detoxifying effect is directly proportional with dosage within the specific limits.
Test two:
Get 20 of qualified mices, body weight is that 30 grams ± 2 grams are divided into S group and T group, and the passive suction of T group nature contains the medicated cigarette of opioid and adds preparation of the present invention, and the passive suction of S group nature contains the medicated cigarette of opioid.Concrete mode is that T to the medicine 0.6ml/ that contains preparation of the present invention only organizes medical ether filling stomach, after administration half an hour, be positioned over two groups of mices in the glass cabinet respectively, link to each other with the Tobacco Control device to form by rubber tube and continue smoke from cigarette and the oxygen that in cabinet input contains opioid with negative pressure, observed 2.5 hours, the result is as follows:
S group reaction T group reaction 1-6 props up substantially normally normal substantially the 7th animal of cigarette suction and concentrates on around the outlet flue dispersion, peace and quiet are closed one's eyes the 15th more, nose ear tail is congested obviously opens eyes more, breathes 120-140 time/minute breathing 95-120 time/minute the 27th dead 1 no dead the 30th dead 26 of dead 1 the 39th dead 3 dead 1 death toll (rate) (60%) 2 (20%) for congested not obvious the 25th
The death of S group all shows as after convulsion is twitched several times dead immediately, meets the performance of opium material poisoning symptom, and the T group when dead above-mentioned symptom not obvious, almost be the deep coma peace and quiet entirely, respiratory arrest death considers to be mainly that CO poisons and the etherization effect causes.
Result of the test shows that the S that takes drugs merely group mouse death rate is 60%, adds 20% of administration T group apparently higher than drug abuse, observes and tests and can see that not administration group mice is subjected to toxicity damage obviously serious than the administration group from the drug abuse process.This test proves that once more the present invention truly has the toxic effect of releasing opioid, irritates stomach and may impel this factor of T group dead mouse as considering ether, and the meeting of T group mice situation is better, illustrate more that also the present invention has the opioid of releasing poison effect.Be subjective symptoms before and after one group of junkie is taken medicine below: after taking medicine before poison day in age at case age taking drugs and take medicine
(year) (year) (g) (ml) case 1g 1 29 half a year 5000 yawn watery nasal discharges one general pain obviously alleviate
Anxiety is fidgety
Gastrointestinal upset does not have the addiction of thinking
Think that the addiction fidgety yawn symptom of shedding tears of case 2 35 2 months 0.5 950 of going to work after heavy February eliminates
Not thinking the energetic case of meal 1g 3 36 half a year 1000 yellow complexions withers and is clearly better
Diet was gone to work after the not good January of becoming thin
4 25 5 years 1g 5250 of lazy, tired, laid up example seriously give up disease being clearly better
The 5 38 10 years 2g 15000 of case that go to work after February seriously give up disease and go to work after April
This result shows, the present invention to junkie, patient all have in various degree, the anti-health-care effect of reverting to take drugs of treatment drug rehabilitation preferably.
The present invention adds other adjuvant material, can be made into medicine, the food of different dosage forms such as chewing gum, tea, fruit jelly, electuary, capsule, becomes drug rehabilitation anti-revert to take drugs medicine and health food.Prove that through clinical trial the present invention is because it has many-sided " regulate, conciliate " effect to human body, so can be used to comprise the rehabilitation auxiliary treatment of the multiple disease of tumor, cardiovascular.
The effective dose of preparation of the present invention is first junkie: contain amount of composition 80-150 gram/day, poison elder in age: contain amount of composition 150-250 gram/day, every day, amount was taken at twice.
The present invention makes by following process: 1, with Folium Apocyni Veneti, Herba Houttuyniae, Radix Platycodonis, Herba Houttuyniae, Xiao Lan green grass or young crops, Ganoderma, Folium Perillae, the mouth stilbene is pulverized, 2, soak repeatedly three times with 90% ethanol, extract supernatant, reclaim ethanol through distillation, make precipitate, 3, Fresh leaf of aloe is got its glue juice, through pulverizing, add 40 ℃ in temperate zone--60 ℃, 15-25 minute, add antioxidant, antiseptic stirs after-filtration and gets Aloe gel resin juice, 4, above-mentioned precipitate is mixed with Aloe gel resin juice, add Mel, Oleum menthae, the Herba Menthae oil mass is promptly made the anti-Chinese medicine preparation of reverting to take drugs that is used to quit drug abuse of the present invention for producing the refrigerant sense of taste, being mixed.
(specific embodiment)
Embodiment 1
1, get Herba Apocyni veneti leaf 2.5 gram, Herba Houttuyniae 5 grams, Radix Platycodonis 5 grams, Radix Glycyrrhizae 2 grams, blue or green 5 grams of Xiao Lan, Ganoderma 2 grams, Folium Perillae 2 grams, mouthful stilbene 3 grams and pulverize,
2, soak repeatedly three times with overlay capacity with 90% ethanol, soaked 3 hours at every turn, collect three times supernatant, reclaim ethanol, make precipitate through distillation,
3, get bright leaf 76 grams of the Chinese aloe aloe (A.evra L.var chinensis), clean, remove the peel, get its glue juice,, add 0.1 gram sodium benzoate, add 0.1 and restrain Vc, stir after-filtration and get Aloe gel resin juice through pulverizing, heating 40 ℃ and kept 15 minutes,
4, above-mentioned precipitate is mixed with Aloe gel resin juice, add Mel 13.5 grams, 0.1 milliliter of Oleum menthae mixes the even preparation of the present invention of all promptly making.
Embodiment 2
1, get Herba Apocyni veneti leaf 100 gram, Herba Houttuyniae 110 grams, Radix Platycodonis 20 grams, Radix Glycyrrhizae 20 grams, blue or green 100 grams of Xiao Lan, Ganoderma 10 grams, Folium Perillae 10 grams, mouthful stilbene 15 grams and pulverize,
2, soak repeatedly three times with overlay capacity with 90% ethanol, soaked 3 hours at every turn, collect three times supernatant, reclaim ethanol, make precipitate through distillation,
3, get bright leaf 640 grams of the Chinese aloe aloe (A.evra L.var chinensis), clean, remove the peel, get its glue juice, kept 20 minutes for 50 ℃ through pulverizing, temperature, add 1 gram sodium benzoate, adding 1 restrains 16 alkanols, and stir after-filtration and get Aloe gel resin juice,
4, above-mentioned precipitate is mixed with Aloe gel resin juice, add Mel 100 grams, 1 milliliter of Oleum menthae mixes the even preparation of the present invention of all promptly making.
Embodiment 3
1, get Herba Apocyni veneti leaf 60 gram, Herba Houttuyniae 100 grams, Radix Platycodonis 7 grams, Radix Glycyrrhizae 8 grams, blue or green 62 grams of Xiao Lan, Ganoderma 10 grams, Folium Perillae 7 grams, mouthful stilbene 10 grams and pulverize,
2, soak repeatedly three times with overlay capacity with 90% ethanol, soaked 3 hours at every turn, collect three times supernatant, reclaim ethanol, make precipitate through distillation,
3, get bright leaf 381 grams of the Chinese aloe aloe (A.evra L.var chinensis), clean, remove the peel, get its glue juice,, stir after-filtration and get Aloe gel resin juice through pulverizing, heating 60 ℃ and kept 25 minutes,
4, above-mentioned precipitate is mixed with Aloe gel resin juice, add Mel 40 grams, mix the even preparation of the present invention of all promptly making.
Embodiment 4
1, get Herba Apocyni veneti leaf 40 gram, Herba Houttuyniae 30 grams, Radix Platycodonis 15 grams, Radix Glycyrrhizae 15 grams, blue or green 30 grams of Xiao Lan, Ganoderma 12 grams, Folium Perillae 12 grams, mouthful stilbene 12 grams and pulverize,
2, articles for use 90% ethanol soaks three times repeatedly with overlay capacity, soaks 3 hours at every turn, collects three times supernatant, reclaims ethanol fully through distillation, makes precipitate,
3, get bright leaf 800 grams of the Chinese aloe aloe (A.evra L.var chinensis), clean, remove the peel, get its glue juice,, add 1 gram sodium benzoate, add 1 and restrain 16 alkanols, stir after-filtration and get Aloe gel resin juice through pulverizing, heating 55 ℃ and kept 20 minutes,
4, above-mentioned precipitate is mixed with Aloe gel resin juice, add Mel 94 grams, mix the even preparation of the present invention of all promptly making
Embodiment 5 capsular preparations
Get the preparation that embodiment 2 or 4 makes, add fillers such as starch, be dried to powdery, insert bottling in the capsule.
The preparation of embodiment 6 chewing gum
Get the preparation that embodiment 3 makes, mix with the chewing gum raw material, chewing gum sugar processing technology is made into chewing gum routinely.
The making of embodiment 7 Chinese medicine confections
Get arbitrary preparation among the embodiment 1-4, add confection juice, butter, the preparation technology of fructose, toffee makes Aloe Chinese medicine confection routinely.
Embodiment 8 freeze cream preparation 1, get the preparation of the present invention that embodiment 4 makes, 2, get 5 gram agar, 100 milliliters of waters soak and add above-mentioned preparation after 30 minutes, 3, heat to 80 ℃ of dissolvings 30 minutes natural cooling, 4, packing, pasteurization, cooling is made and is frozen cream type health product.
Claims (7)
1, a kind of anti-Chinese medicine preparation of reverting to take drugs that is used to quit drug abuse, it is characterized in that it mainly being by following raw materials by weight preparation, Fresh leaf of aloe 50-80%, small Qinglan 1-10%, Folium Apocyni Veneti 1-10%, Herba Houttuyniae 1-10%, Radix Platycodonis 1-2%, Folium Perillae 1-2%, Ganoderma 1-2%, mouth stilbene 1-2%, Radix Glycyrrhizae 1-2%, Mel 8-14%.
2, the anti-Chinese medicine preparation of reverting to take drugs that is used to quit drug abuse according to claim 1 is characterized in that the percentage by weight of Fresh leaf of aloe is 65-75%.
The 3 anti-Chinese medicine preparation of reverting to take drugs that are used to quit drug abuse according to claim 1 is characterized in that the percentage by weight of small Qinglan is 2-4%.
4, the anti-Chinese medicine preparation of reverting to take drugs that is used to quit drug abuse according to claim 1 is characterized in that, contains Herba Menthae.
5, the anti-Chinese medicine preparation of reverting to take drugs that is used to quit drug abuse according to claim 1 is characterized in that, contains Radix Ginseng, Radix Codonopsis or Radix Pseudostellariae that percentage by weight is 1-10%.
6, it is characterized in that according to a kind of described anti-Chinese medicine preparation of reverting to take drugs that is used to quit drug abuse among the claim 1-5, in contain preservative benzoic acid 1%, also contain antioxidant V-C1%, or 16 alkanols 1%.
7, a kind of anti-Chinese medicine preparation of reverting to take drugs that is used to quit drug abuse according to claim 1 is characterized in that, is equipped with medicine or food acceptable additive, makes oral liquid, capsule, chewing gum, tea or confection.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005102370A1 (en) * | 2004-04-23 | 2005-11-03 | Qixin Wu | Chinese medicine for stopping drug addiction |
| EP2083633A4 (en) * | 2006-10-11 | 2012-01-18 | Wrigley W M Jun Co | Oral delivery vehicles containing a traditional chinese medicine of extract thereof |
| CN103141729A (en) * | 2013-03-25 | 2013-06-12 | 胡敏 | Fruit jelly for giving up drinking |
| CN104644730A (en) * | 2013-11-19 | 2015-05-27 | 深圳市日月昌科技有限公司 | Detoxification-used traditional Chinese medicine composition and preparation method thereof |
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2002
- 2002-06-21 CN CNB021333440A patent/CN1248709C/en not_active Expired - Fee Related
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005102370A1 (en) * | 2004-04-23 | 2005-11-03 | Qixin Wu | Chinese medicine for stopping drug addiction |
| EP2083633A4 (en) * | 2006-10-11 | 2012-01-18 | Wrigley W M Jun Co | Oral delivery vehicles containing a traditional chinese medicine of extract thereof |
| CN103141729A (en) * | 2013-03-25 | 2013-06-12 | 胡敏 | Fruit jelly for giving up drinking |
| CN104644730A (en) * | 2013-11-19 | 2015-05-27 | 深圳市日月昌科技有限公司 | Detoxification-used traditional Chinese medicine composition and preparation method thereof |
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| CN1248709C (en) | 2006-04-05 |
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