CN1403148A - Medicines composition for treating coronary heart disease ventricular premature beat and its prepn - Google Patents

Abstract

The invention provides a pharmaceutical composition based on the TCM theory of nourishing qi and nourishing yin, promoting blood circulation and dredging collaterals, clearing the heart and calming the nerves, and achieves the therapeutic purpose of restoring the normal rhythm of the heart by dredging the blood vessels and nourishing the heart-qi. The medicinal composition for treating ventricular premature beats of coronary heart disease comprises 45-180 parts of ginseng, 50-200 parts of Ophiopogon japonicus, 125-450 parts of Cornus officinalis, 125-450 g of salvia miltiorrhiza, 95-400 parts of jujube seed (stir-fried), 95-400 parts of mulberry, 45-200 parts of red peony, 35-150 parts of ground beetle, 45-200 parts of Gansong, 25-90 parts of coptis, 35-150 parts of southern Schisandra, and 75-300 parts of keel. According to the pharmacological test research of Xiyuan Hospital of China Academy of Traditional Chinese Medicine, the capsule of the present invention has obvious preventive effect on arrhythmia in mice caused by CaCl ₂ , and the incidence of arrhythmia is significantly reduced, and the arrhythmia in rats caused by aconitine is significantly reduced. duration.

Description

A kind of pharmaceutical composition and preparation method for treating ventricular premature beats of coronary heart disease

technical field

The invention relates to a pharmaceutical composition for treating ventricular premature beats of coronary heart disease and a preparation method, which belongs to the technical field of Chinese herbal medicine preparations, and is especially suitable for clinically treating palpitations, shortness of breath, arrhythmia and ventricular premature beats.

Background technique

Ventricular premature beats in coronary heart disease are a type of arrhythmia-type coronary heart disease. Its main pathogenesis can be summarized from the theory of traditional Chinese medicine as deficiency of both qi and yin, stasis of heart collaterals, and blockage of blood stasis and collaterals. . At present, traditional Chinese medicine preparations such as Qidong Yixin oral liquid (replenishing qi and nourishing the heart, calming the nerves and relieving palpitations), Luobusang oral liquid (reinforcing qi and nourishing yin, promoting blood circulation and unblocking the pulse), Fumaiding Granules (replenishing qi and blood circulation, calming the mind and calming the nerves) ), Guanxin Shengmai Oral Liquid (replenishing Qi and promoting body fluid, promoting blood circulation and unblocking the pulse), Shengmai Granules (replenishing Qi and rejuvenating the pulse, nourishing Yin and promoting body fluid), Yangxin Dingpal Oral Liquid (nourishing blood and Qi, rejuvenating the pulse and relieving palpitations), etc. None of them treat palpitations (ventricular premature beats in coronary heart disease), and most of them only consider the deficiency of both Qi and Yin, blood stasis, and restlessness, but do not consider the characteristic of blood stasis and heat. Therefore, the curative effect is not significant.

Contents of the invention

Combining with the modern pharmacological research of traditional Chinese medicine, the present invention provides a drug combination based on deficiency-based ventricular premature beats and the pathogenesis characteristics of blood stasis and heat, based on the theory of Chinese medicine for nourishing qi and nourishing yin, promoting blood circulation and dredging collaterals, clearing the heart and calming the nerves. The purpose of treatment is to restore the normal rhythm of the heart by unblocking the blood vessels and nourishing the heart.

The technical scheme of the present invention is achieved in the following way: the pharmaceutical composition for treating premature ventricular contractions of coronary heart disease comprises 45-180 parts of ginseng, 50-200 parts of Radix Ophiopogon japonicus, 125-450 parts of Cornus officinalis, 125-450 g of Danshen, Suanzaoren (fried) 95-400 parts, Sangjisheng 95-400 parts, Radix Paeoniae Rubra 45-200 parts, Wood Beetle 35-150 parts, Gansong 45-200 parts, Coptidis 25-90 parts, Southern Schisandra 35-150 parts , Keel 75-300 parts.

The pharmaceutical composition for the treatment of premature ventricular contractions in coronary heart disease comprises 89 parts of ginseng, 112 parts of Ophiopogon japonicus, 224 parts of Cornus officinalis, 224 g of Salvia miltiorrhiza, 186 parts of Suanzaoren (stir-fried), 186 parts of Sangjisheng, and 89 parts of Radix Paeoniae Rubra. 75 parts, 75 parts of ground beetle, 89 parts of Gansong, 45 parts of Coptis chinensis, 67 parts of Southern Schisandra, and 149 parts of keel.

The composition of the pharmaceutical composition for treating ventricular premature beats of coronary heart disease can also include: rehmannia glutinosa, raw rehmannia root, acacia bark, magnet, polygala, Atractylodes macrocephala, calcined oyster, Bupleurum, plantago seed, Tinglizi, Polygonatum odoratum, One or more of tangerine peel, citrus aurantium, red peony root, pinellia, cinnamon twig, vine, and alisma.

The preparation method of the pharmaceutical composition for the above-mentioned treatment of coronary heart disease ventricular premature beats comprises:

(1) 89 parts of ginseng plus 8 times the amount of 70% ethanol were reflux extracted three times, the first time was 3 hours, and each subsequent time was 2 hours, the extracts were combined, filtered, ethanol was recovered, concentrated, dried, and crushed into 80 mesh powder ;

(2), 67 parts of Schisandra chinensis, 224 parts of Cornus officinalis, 224 parts of Salvia miltiorrhiza, 45 parts of Coptis chinensis, 89 parts of Gansong plus 8 times the amount of 70% ethanol for reflux extraction 3 times, combined extracts, filtered, and recovered ethanol;

(3), 75 parts of ground beetle are ground into 80 mesh powders;

(4), 112 parts of Ophiopogon japonicus, 186 parts of Suanzaoren (stir-fried), 186 parts of Sangjisheng, 89 parts of Radix Paeoniae Rubra, 149 parts of keel, add water to 9 times the amount and decoct twice, combine the extracts, filter, and step (3) ) extracts are combined, concentrated, mixed evenly with the powders of steps (1) and (4), dried, crushed into 80 mesh powders, and packed into capsules.

The dry paste mixture made by the steps (1), (2), (3), and (4) of the preparation method of the pharmaceutical composition for the treatment of coronary heart disease ventricular premature beats can be used to clinically prepare tablets, granules, and powders basic raw materials.

The pharmacological test research of Xiyuan Hospital of Chinese Academy of Traditional Chinese Medicine shows that the capsules of the present invention (trade name is Anxintai or Shensong Yangxin Capsules) have a significant preventive effect on the arrhythmia of mice caused by _CaCL2 , and the incidence of arrhythmia is obvious. Reduce, significantly reduce the duration of aconitine-induced arrhythmia in rats; it has obvious protective effect on ouabain-induced arrhythmia in guinea pigs, and the consumption of ouabain when animals have premature ventricular contractions, ventricular tachycardia, and ventricular fibrillation All significantly increased; the above tests were significantly different from the model group. Simultaneously, the present invention can alleviate the degree of arrhythmia in rat myocardial ischemia-reperfusion injury model, reduce serum creatine phosphokinase (CK), lactate deoxyhydrogenase (LDH) and malondialdehyde (MDA) content, increase serum superoxidation Substance dismutase (SOD) activity, increase the Na ⁺ of reperfusion blood muscle tissue, K ^- ATPase activity, to anesthetized canine heart hemodynamics and myocardial oxygen consumption experimental result shows, the present invention can obviously reduce arterial blood pressure, reduce Coronary resistance, reducing myocardial oxygen consumption and oxygen consumption index, thereby providing energy guarantee for myocardial cell activity and improving stress status.

The acute toxicity test in mice shows that the clinical dosage of the capsule of the present invention is 17.3g/day, and the oral maximum tolerated dosage of mice is 129.6g/kg, which is equivalent to 524 times of the adult clinical dosage, and the animals have no obvious abnormality and death. The long-term toxicity test shows that the capsule of the present invention has no obvious influence on the general condition, body weight, blood picture and other biochemical indexes of the rats and the coefficients of major organs, indicating that the present invention has no obvious toxic reaction. see attached.

Detailed ways

The specific implementation of the present invention will be described below in conjunction with the examples of the pharmaceutical combination of the present invention.

Example 1: Ginseng 89g Ophiopogon japonicus 112g Cornus officinalis 224g Salvia miltiorrhiza 224g Suanzaoren (stir-fried) 186g Sangjisheng 186g Chishao 89g Ground beetle 75g Gansong 89g Coptidis 45g Longan 67g schisandra

(1) 89 parts of ginseng plus 8 times the amount of 70% ethanol were reflux extracted three times, the first time was 3 hours, and each subsequent time was 2 hours, the extracts were combined, filtered, ethanol was recovered, concentrated, dried, and crushed into 80 mesh powder ;

(2), 67 parts of Schisandra chinensis, 224 parts of Cornus officinalis, 224 parts of Salvia miltiorrhiza, 45 parts of Coptis chinensis, 89 parts of Gansong plus 8 times the amount of 70% ethanol for reflux extraction 3 times, combined extracts, filtered, and recovered ethanol;

(3), 75 parts of ground beetle are ground into 80 mesh powders;

(4), 112 parts of Ophiopogon japonicus, 186 parts of Suanzaoren (stir-fried), 186 parts of Sangjisheng, 89 parts of Radix Paeoniae Rubra, 149 parts of keel, add water to 9 times the amount and decoct twice, combine the extracts, filter, and step (3) ) extracts are combined, concentrated, mixed evenly with the powders of steps (1) and (4), dried, crushed into 80 mesh powders, and packed into capsules.

Example 2. Ginseng 45g Ophiopogon japonicus 112g Cornus officinalis 224g Salvia miltiorrhiza 225g Suanzaoren (stir-fried) 186g Sangjisheng 186g Radix peony root 89g Upper turtle worm 35g Gansong 45g Coptidis 45g Longlian 67g South Schisandra 1 g 9

Example 3. Ginseng 90g Ophiopogon japonicus 200g Cornus officinalis 450g Salvia miltiorrhiza 450g Suanzaoren (stir-fried) 400g Sangjisheng 186g Radix peony 89g Ground beetle 75g Gansong 90g Coptidis 90g Longlian 70g South Schisandra 1 g 0

Example 4. Astragalus 89g Ophiopogon japonicus 112g Rehmannia glutinosa 224g Salvia miltiorrhiza 224g Suanzaoren (stir-fried) 186g Sangjisheng 186g Radix peony 89g Ground beetle 75g Gansong 89g Coptidis 45g Southern Schisandra 67g

Example 5. Ginseng 180g Ophiopogon japonicus 112g Cornus officinalis 224g Salvia miltiorrhiza 224g Suanzaoren (stir-fried) 186g Sangjisheng 186g Radix peony 89g Magnetic bark 75g Gansong 89g Huanlian 45g Coptis chinensis 67g 9

Example 6. Ginseng 45g Atractylodes macrocephala 220g Fushen 150g Astragalus 250g Polygala 150g Suanzao 180g Aconite 100g Guizhi 80g Salvia 225g Safflower 100g Glycyrrhizae 8

Example 7. Astragalus 450g Ginseng 89g Atractylodes macrocephala 225g Poria cocos 90g Suanzaoren (stir-fried) 89g Woody fragrance 68g Ophiopogon japonicus 112g Rehmannia glutinosa 100g Cornus officinalis 225g Albizia juniper 90g 0 g Calcined lotus seed heart 86g

Example 8. Ginseng 45g Astragalus 150g Ophiopra 112g Atractylodes 225g Coptisite 45g Coptisite 45g Bai Baiji 50g jujube kernel (fried) 89 Salva 225g Cooked Land 145g Copyca 45g Light Belly Light Vineto 90g Bai Ziren 45g 45g 45g

Example 9. Astragalus 450g Ginseng 45g Atractylodes 225g Aperton 45G Guizhi 90g 苈 苈 45G Southern Wuxi 67g Earlier 35G Zexie 90g Summachi 225g Nanwu Schisandra 67g Castle 300g Oyster 45g Licorice 150g

Example 10. Ginseng 89G astragalus 250g Ophiopogon 150g Yuzhu 90g jujube kernel (fried) 89g mulberry parasitic 186g Salva 225g red peony 89g Poria 90g Guizhi 45g 泻 苈 苈 苈 45g anti -self 45g licorice 90g implementation 11, ginseng 89g 89g Astragalus 250g Ophiopogon japonicus 150g Polygonatum 90g Suanzaoren (stir-fried) 89g Sangjisheng 186 Salvia miltiorrhiza 225g Red peony 89g Shengdi 90g Angelica 90g Bupleurum 45g Whole Trichosanthes 150g Peach kernel 9 g 9 g Flowers

Example 12. Ginseng 89g Astragalus 250g Ophiopogon japonicus 150 Polygonatum 90g Suanzaoren (stir-fried) 89g Nanwujiapi 186g Salvia 225g Radix peony 89g Coptidis 45g Pinellia 45g Tangerine peel 98g 9 g 5 g Citrus aurantium 4

The dry cream mixture prepared by the preparation method of the above embodiment can be used as the basic raw material for the clinical preparation of oral preparations such as tablets, granules, and powders. The preparation method of Examples 2-12 is basically the same as that of Example 1.

Claims (5)

1. A pharmaceutical composition for treating premature ventricular contractions in coronary heart disease, which comprises 45-180 parts of ginseng, 50-200 parts of Ophiopogon japonicus, 125-450 parts of Cornus officinalis, 125-450 g of salvia miltiorrhiza, 95-400 parts of jujube seed (stir-fried) 95-400 parts of Sangjisheng, 45-200 parts of Radix Paeoniae Rubra, 35-150 parts of Wood Beetle, 45-200 parts of Gansong, 25-90 parts of Coptidis, 35-150 parts of Southern Schisandra, and 75-300 parts of keel. 2. The pharmaceutical composition for treating premature ventricular contractions of coronary heart disease according to claim 1, the composition ratio of which is 89 parts of ginseng, 112 parts of Radix Ophiopogon, 224 parts of Cornus officinalis, 224 g of Salvia miltiorrhiza, 186 parts of Jujube Seed (stir-fried), 186 parts of Sangjisheng 186 parts, 89 parts of red peony root, 75 parts of ground beetle, 89 parts of Gansong, 45 parts of coptis, 67 parts of southern schisandra, and 149 parts of keel. 3. The pharmaceutical composition for treating ventricular premature beats of coronary heart disease according to claim 1, its composition may further include: rehmannia glutinosa, raw rehmannia root, acacia bark, magnetite, polygala, atractylodes macrocephala, calcined oyster, Bupleurum chinensis, Semen Plantaginis, Ting One or more of zizi, yuzhu, tangerine peel, citrus aurantium, red peony root, pinellia, osmanthus twig, vine, and alisma. 4. The preparation method of the pharmaceutical composition for the above-mentioned treatment of premature ventricular contractions of coronary heart disease comprises: (1) 89 parts of ginseng plus 8 times the amount of 70% ethanol were reflux extracted three times, the first time was 3 hours, and each subsequent time was 2 hours, the extracts were combined, filtered, ethanol was recovered, concentrated, dried, and crushed into 80 mesh powder ; (2), 67 parts of Schisandra chinensis, 224 parts of Cornus officinalis, 224 parts of Salvia miltiorrhiza, 45 parts of Coptis chinensis, 89 parts of Gansong plus 8 times the amount of 70% ethanol for reflux extraction 3 times, combined extracts, filtered, and recovered ethanol; (3), 75 parts of ground beetle are ground into 80 mesh powders; (4), 112 parts of Ophiopogon japonicus, 186 parts of Suanzaoren (stir-fried), 186 parts of Sangjisheng, 89 parts of Radix Paeoniae Rubra, 149 parts of keel, add water to 9 times the amount and decoct twice, combine the extracts, filter, and step (3) ) extracts are combined, concentrated, mixed evenly with the powders of steps (1) and (4), dried, crushed into 80 mesh powders, and packed into capsules. 5. The preparation method of the pharmaceutical composition for treating premature ventricular contractions of coronary heart disease according to claim 4, characterized in that the dry paste mixture made in steps (1), (2), (3), and (4) can be used It is the basic raw material for clinically preparing tablets, granules and powders.