CN1493358A - Devilpepper drip pill and its preparation method - Google Patents
Devilpepper drip pill and its preparation method Download PDFInfo
- Publication number
- CN1493358A CN1493358A CNA031591965A CN03159196A CN1493358A CN 1493358 A CN1493358 A CN 1493358A CN A031591965 A CNA031591965 A CN A031591965A CN 03159196 A CN03159196 A CN 03159196A CN 1493358 A CN1493358 A CN 1493358A
- Authority
- CN
- China
- Prior art keywords
- radix rauvolfiae
- rauwolfia
- coolant
- preparation
- polyethylene glycol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Medicinal Preparation (AREA)
Abstract
A dripping pill of devilpepper and its superfine pulverizing process for preparing it is disclosed. Its advantages are high dissolving and disintegrating speed, high stripping percentage and low cost.
Description
Technical field
The present invention relates to a kind of pharmaceutical product and preparation method thereof, specifically Radix Rauvolfiae drop pill and preparation method thereof.
Background technology
Radix Rauvolfiae (Rauwolfia) is to extract the mixed biologic alkali that obtains in the root of apocynaceae plant Radix Rauvolfiae Rauwolfia Verlicillata (Lour) Baill, Rauvolfia yunnanensis Rauwolfia yunnanensis Tsiang, Rauvolfia verticillata (Lour.) Baill. var. hainanensis Tsiang Rauwolfia Verlicillata hainanensis or the rhizome, main component is a reserpine, hypotensive effect is similar to reserpine, but effect relaxes than reserpine.Reserpine is exhausted the norepinephrine storage of sympathetic nerve terminal on every side, also makes catecholamine and 5-hydroxy tryptamine in brain, the heart and other organs store exhaustion.Blood pressure lowering with around act as the master, peripheral vascular resistance reduces, decreased heart rate, cardiac output reduces, thereby makes blood pressure drops.
The oral post-absorption of reserpine in the Radix Rauvolfiae is fast, and average 3.5 hours blood drug level peakings are distributed to main organs rapidly, comprise that the cerebral tissue bioavailability is about 50%, onset is slow, all blood pressure lowering onsets of a couple of days to 3,3-6 week reaches the peak, and effect continues 1-6 week after the drug withdrawal.t
1/2 αAnd t
1/2 βBe respectively 4.5 hours and 45-168 hour, eliminating the half-life during anuria is 87～323 hours.About 96% combines with plasma protein.Mainly at intrahepatic metabolism.60% above oral medicine is discharged from feces after 3-4 days with former medicine form administration, and 8% discharges from urine, is the original shape medicine less than 1% wherein.List marketing at present tablet, the clinical early high blood pressure height that is used for only arranged.
The Radix Rauvolfiae bitter in the mouth, insoluble in water, its disintegration of tablet time is long, and the supplementary product consumption ratio is big, and child, old people, bed patient and dysphagia patients are taken inconvenience, and compliance is poor, has influenced the performance of Radix Rauvolfiae therapeutical effect.
The present invention makes the Radix Rauvolfiae drop pill by using ultramicro communication technique and dropping pill formulation Technology exactly, thereby overcomes the above defective of Radix Rauvolfiae sheet, and the therapeutical effect of Radix Rauvolfiae is given full play to.
Summary of the invention
The Radix Rauvolfiae drop pill of making by using ultramicro communication technique and dropping pill formulation Technology not only have disintegrate molten loose fast, steady quality, the pill volume is little, and is easy to carry and use, and onset is rapid, compliance is good, be particularly suitable for the characteristics that child, old people, bed patient and dysphagia patients are taken, but also have working condition and production equipment is simple, production cost is low, compare the advantage that supplementary product consumption reduces with tablet, demonstrated fully the new drug research exploitation spirit that people-oriented.
For achieving the above object, the present invention by the following technical solutions: the Radix Rauvolfiae fine powder of 1 weight portion through micronizing is added in 1～10 weight portion molten matrix, abundant mixing, dropping preparation method is condensed into ball in coolant, remove coolant, drying, promptly.
Radix Rauvolfiae among the present invention (Rauwolfia) is to extract the mixed biologic alkali that obtains in the root of apocynaceae plant Radix Rauvolfiae RauwolfiaVerlicillata (Lour) Baill, Rauvolfia yunnanensis Rauwolfia yunnanensis Tsiang, Rauvolfia verticillata (Lour.) Baill. var. hainanensis Tsiang Rauwolfia Verlicillata hainanensis or the rhizome.
Substrate among the present invention includes but not limited to polyethylene glycol 6000, Macrogol 4000, polyethylene glycol 1500, cetomacrogol 1000, sodium stearate, glycerin gelatine, poloxamer, stearic acid, glycerol monostearate acid, insect wax etc.
Coolant among the present invention includes but not limited to dimethicone, liquid paraffin, vegetable oil, water, alcoholic solution etc.
Below through detecting to beneficial effect of the present invention as directed
One, detects index and method
Disintegrate (molten loosing) time limit: check according to inspection technique disintegration (two appendix XA of Chinese Pharmacopoeia version in 2000).
Two, commercially available Radix Rauvolfiae sheet disintegration time testing result: 62 minutes
Three, example 1 sample disintegrate (molten loosing) time detecting result: 62 minutes
Four, example 2 sample disintegrates (molten loosing) time detecting result: 5 minutes
Five, example 3 sample disintegrates (molten loosing) time detecting result: 8 minutes
Six, example 4 sample disintegrates (molten loosing) time detecting result: 6 minutes
Seven, example 5 sample disintegrates (molten loosing) time detecting result: 10 minutes
Eight, example 6 sample disintegrates (molten loosing) time detecting result: 15 minutes
The specific embodiment
One, example 1
Prescription:
Radix Rauvolfiae 4g
Polyethylene glycol 6000 16g
Make 1000
Method for making: the Radix Rauvolfiae fine powder that the micronizing of learning from else's experience is crossed 200 mesh sieves is added in the fused polyethylene glycol 6000 substrate, stirs evenly, and with the dimethicone coolant, the dropping preparation method pill, drying, promptly.
Two, example 2
Prescription:
Radix Rauvolfiae 4g
Macrogol 4000 16g
Make 1000
Method for making: the Radix Rauvolfiae fine powder that the micronizing of learning from else's experience is crossed 200 mesh sieves is added in the fused Macrogol 4000 substrate, stirs evenly, and with the dimethicone coolant, the dropping preparation method pill, drying, promptly.
Three, example 3
Prescription:
Radix Rauvolfiae 4g
Polyethylene glycol 6000 6g
Macrogol 4000 10g
Make 1000
Method for making: the Radix Rauvolfiae fine powder that the micronizing of learning from else's experience is crossed 200 mesh sieves is added to fused Macrogol 4000 and the polyethylene glycol 6000 elder brother closes in the substrate, stirs evenly, and be coolant with the dimethicone, the dropping preparation method pill, drying, promptly.
Four, example 4
Prescription:
Radix Rauvolfiae 4g
Glyceryl monostearate 16g
Make 1000
Method for making: the Radix Rauvolfiae fine powder that the micronizing of learning from else's experience is crossed 200 mesh sieves is added in the fused glyceryl monostearate substrate, and mixing is a coolant with the frozen water, the dropping preparation method pill, and drying, promptly.
Five, example 5
Prescription:
Radix Rauvolfiae 4g
Polyethylene glycol 6000 10g
Poloxamer 6g
Make 1000
Method for making: the Radix Rauvolfiae fine powder that the micronizing of learning from else's experience is crossed 200 mesh sieves is added in fused polyethylene glycol 6000 and the poloxamer mixed-matrix, stirs evenly, and with the dimethicone coolant, the dropping preparation method pill, drying, promptly.
Six, example 6
Prescription:
Radix Rauvolfiae 4g
Glyceryl monostearate 15g
Poloxamer 1g
Make 1000
Method for making: get the mixing fine powders that Radix Rauvolfiae and poloxamer cross 200 mesh sieves through micronizing and be added in the fused glyceryl monostearate substrate, mixing is a coolant with the frozen water, the dropping preparation method pill, and drying, promptly.
Claims (4)
1. Radix Rauvolfiae drop pill and preparation method thereof is characterized in that: the Radix Rauvolfiae fine powder of 1 weight portion through micronizing is added in 1～10 weight portion molten matrix, and abundant mixing, dropping preparation method is condensed into ball in coolant, remove coolant, drying, promptly.
2. the described Radix Rauvolfiae Rauwolfia of claim 1 extracts the mixed biologic alkali that obtains in the root of apocynaceae plant Radix Rauvolfiae RauwolfiaVerlicillata Lour Baill, Rauvolfia yunnanensis Rauwolfia yunnanensis Tsiang, Rauvolfia verticillata (Lour.) Baill. var. hainanensis Tsiang Rauwolfia Verlicillata hainanensis or the rhizome.
3. the described substrate of claim 1 includes but not limited to polyethylene glycol 6000, Macrogol 4000, polyethylene glycol 1500, cetomacrogol 1000, sodium stearate, glycerin gelatine, poloxamer, stearic acid, glycerol monostearate acid, insect wax etc.
4. the described coolant of claim 1 includes but not limited to dimethicone, liquid paraffin, vegetable oil, water, alcoholic solution etc.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA031591965A CN1493358A (en) | 2003-09-10 | 2003-09-10 | Devilpepper drip pill and its preparation method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA031591965A CN1493358A (en) | 2003-09-10 | 2003-09-10 | Devilpepper drip pill and its preparation method |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1493358A true CN1493358A (en) | 2004-05-05 |
Family
ID=34240932
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA031591965A Pending CN1493358A (en) | 2003-09-10 | 2003-09-10 | Devilpepper drip pill and its preparation method |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1493358A (en) |
-
2003
- 2003-09-10 CN CNA031591965A patent/CN1493358A/en active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN1490000A (en) | Hippophae rhamnoide flavone drops and preparation thereof | |
| CN1493358A (en) | Devilpepper drip pill and its preparation method | |
| CN1528324A (en) | Herba centellae total aglycone drop pill and preparing method thereof | |
| CN1582929A (en) | Aparkan drops and their preparation | |
| CN1490008A (en) | Minlpress hydrochloride drops and preparation thereof | |
| CN1528321A (en) | Rhizoma gastrodiae extract drop pill and preparing method thereof | |
| CN1528306A (en) | Noscapine drop pill and preparing method thereof | |
| CN1528317A (en) | Cucurbitacin drop pill and preparing method thereof | |
| CN1528299A (en) | Bisacodyl drop pill and preparing method thereof | |
| CN1528304A (en) | Anisodine hydrobromide drop pill and preparing method thereof | |
| CN1493281A (en) | Coumarin acetate drip pill and its preparation method | |
| CN1528320A (en) | Acetyl rhizoma gastrodiae extract drop pill and preparing method thereof | |
| CN1490015A (en) | Thevina drops and preparation thereof | |
| CN1301094C (en) | Throat pain relieving anti-inflammation drop pills for treating oral disease and preparation method thereof | |
| CN1528287A (en) | Herba lysionoti extract drop pill and preparing method thereof | |
| CN1528274A (en) | Methoxyphenamine hydrochloride drop pill and preparing method thereof | |
| CN1528338A (en) | Thunder godvine multi-aglycone drop pill and preparing method thereof | |
| CN1490007A (en) | Quinoline coridalis B drops and preparation thereof | |
| CN1528281A (en) | Rhododeudron molle toxin drop pill and preparing method thereof | |
| CN1543980A (en) | Mohailin dripping pills and its preparation | |
| CN1528305A (en) | Radix sen rhizoma fibraureae extract drop pill and preparing method thereof | |
| CN1543935A (en) | Tulobuterol hydrochloride guttate pill and method for preparing the same | |
| CN1528298A (en) | Isocarboxazid drop pill and preparing method thereof | |
| CN1493288A (en) | Hanfangchin A drip pill and its preparation method | |
| CN1528294A (en) | Indolol drop pill and preparing method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |