CN1481865A - Complex plant estrogen formulation which can delay female senility and method preparing same - Google Patents
Complex plant estrogen formulation which can delay female senility and method preparing same Download PDFInfo
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- CN1481865A CN1481865A CNA031283381A CN03128338A CN1481865A CN 1481865 A CN1481865 A CN 1481865A CN A031283381 A CNA031283381 A CN A031283381A CN 03128338 A CN03128338 A CN 03128338A CN 1481865 A CN1481865 A CN 1481865A
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- isoflavone
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- folium ginkgo
- fructus rubi
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- 239000000262 estrogen Substances 0.000 title claims abstract description 19
- 229940011871 estrogen Drugs 0.000 title claims abstract description 19
- 239000000203 mixture Substances 0.000 title claims description 12
- 238000000034 method Methods 0.000 title claims description 4
- 238000009472 formulation Methods 0.000 title description 2
- GOMNOOKGLZYEJT-UHFFFAOYSA-N isoflavone Chemical compound C=1OC2=CC=CC=C2C(=O)C=1C1=CC=CC=C1 GOMNOOKGLZYEJT-UHFFFAOYSA-N 0.000 claims abstract description 37
- CJWQYWQDLBZGPD-UHFFFAOYSA-N isoflavone Natural products C1=C(OC)C(OC)=CC(OC)=C1C1=COC2=C(C=CC(C)(C)O3)C3=C(OC)C=C2C1=O CJWQYWQDLBZGPD-UHFFFAOYSA-N 0.000 claims abstract description 37
- 235000008696 isoflavones Nutrition 0.000 claims abstract description 37
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims abstract description 32
- 238000002360 preparation method Methods 0.000 claims abstract description 28
- 244000068988 Glycine max Species 0.000 claims abstract description 20
- 235000010469 Glycine max Nutrition 0.000 claims abstract description 20
- 229910000019 calcium carbonate Inorganic materials 0.000 claims abstract description 16
- 241000196324 Embryophyta Species 0.000 claims abstract description 9
- 238000001914 filtration Methods 0.000 claims abstract description 7
- 238000012856 packing Methods 0.000 claims abstract description 4
- 241000218628 Ginkgo Species 0.000 claims description 20
- 235000011201 Ginkgo Nutrition 0.000 claims description 20
- 235000008100 Ginkgo biloba Nutrition 0.000 claims description 20
- 230000032683 aging Effects 0.000 claims description 15
- SRFKWQSWMOPVQK-UHFFFAOYSA-K sodium;2-[2-[bis(carboxylatomethyl)amino]ethyl-(carboxymethyl)amino]acetate;iron(2+) Chemical compound [Na+].[Fe+2].OC(=O)CN(CC([O-])=O)CCN(CC([O-])=O)CC([O-])=O SRFKWQSWMOPVQK-UHFFFAOYSA-K 0.000 claims description 14
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 11
- 239000003814 drug Substances 0.000 claims description 9
- 238000010438 heat treatment Methods 0.000 claims description 9
- 239000002131 composite material Substances 0.000 claims description 7
- 239000000706 filtrate Substances 0.000 claims description 6
- 238000004659 sterilization and disinfection Methods 0.000 claims description 5
- 239000008187 granular material Substances 0.000 claims description 4
- 239000004615 ingredient Substances 0.000 claims description 3
- 239000000047 product Substances 0.000 claims description 3
- 238000010298 pulverizing process Methods 0.000 claims description 3
- 239000002893 slag Substances 0.000 claims description 3
- 229940079593 drug Drugs 0.000 claims description 2
- 235000011389 fruit/vegetable juice Nutrition 0.000 claims description 2
- 239000008280 blood Substances 0.000 abstract description 4
- 210000004369 blood Anatomy 0.000 abstract description 4
- 230000028327 secretion Effects 0.000 abstract description 4
- 230000036772 blood pressure Effects 0.000 abstract description 3
- 150000001875 compounds Chemical class 0.000 abstract description 3
- 208000011580 syndromic disease Diseases 0.000 abstract description 3
- 150000003254 radicals Chemical class 0.000 abstract description 2
- 244000194101 Ginkgo biloba Species 0.000 abstract 2
- 240000007651 Rubus glaucus Species 0.000 abstract 2
- 235000011034 Rubus glaucus Nutrition 0.000 abstract 2
- 235000009122 Rubus idaeus Nutrition 0.000 abstract 2
- 230000001954 sterilising effect Effects 0.000 abstract 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 abstract 1
- 244000046146 Pueraria lobata Species 0.000 abstract 1
- 235000010575 Pueraria lobata Nutrition 0.000 abstract 1
- 238000001035 drying Methods 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 238000002156 mixing Methods 0.000 abstract 1
- 239000002674 ointment Substances 0.000 abstract 1
- 210000001672 ovary Anatomy 0.000 abstract 1
- 230000003647 oxidation Effects 0.000 abstract 1
- 238000007254 oxidation reaction Methods 0.000 abstract 1
- 238000007873 sieving Methods 0.000 abstract 1
- 239000011734 sodium Substances 0.000 abstract 1
- 229910052708 sodium Inorganic materials 0.000 abstract 1
- 230000000694 effects Effects 0.000 description 7
- 208000024891 symptom Diseases 0.000 description 7
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 6
- 239000011575 calcium Substances 0.000 description 5
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 4
- 229910052791 calcium Inorganic materials 0.000 description 4
- 238000005516 engineering process Methods 0.000 description 3
- 238000000605 extraction Methods 0.000 description 3
- 230000002611 ovarian Effects 0.000 description 3
- 206010019233 Headaches Diseases 0.000 description 2
- 206010030247 Oestrogen deficiency Diseases 0.000 description 2
- 206010067572 Oestrogenic effect Diseases 0.000 description 2
- 208000001132 Osteoporosis Diseases 0.000 description 2
- 208000002173 dizziness Diseases 0.000 description 2
- 230000002996 emotional effect Effects 0.000 description 2
- 230000001076 estrogenic effect Effects 0.000 description 2
- 231100000869 headache Toxicity 0.000 description 2
- 208000028867 ischemia Diseases 0.000 description 2
- 239000003075 phytoestrogen Substances 0.000 description 2
- 239000011573 trace mineral Substances 0.000 description 2
- 235000013619 trace mineral Nutrition 0.000 description 2
- 241000756943 Codonopsis Species 0.000 description 1
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 1
- 241001619461 Poria <basidiomycete fungus> Species 0.000 description 1
- 208000003251 Pruritus Diseases 0.000 description 1
- 206010037660 Pyrexia Diseases 0.000 description 1
- 241000405414 Rehmannia Species 0.000 description 1
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 description 1
- 206010048222 Xerosis Diseases 0.000 description 1
- 230000003712 anti-aging effect Effects 0.000 description 1
- 230000000259 anti-tumor effect Effects 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 206010022437 insomnia Diseases 0.000 description 1
- 230000009245 menopause Effects 0.000 description 1
- 230000027758 ovulation cycle Effects 0.000 description 1
- 230000005180 public health Effects 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 210000000582 semen Anatomy 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The compound plant estrogen preparation capable of delaying female's senility is compounded with kudzu vine root isoflavone, soybean isoflavone, biological calcium carbonate, ferric sodium edelate, Korean raspberry and gingko leaf. The preparation process includes decocting Korean raspberry and gingko leaf, filtering to eliminate dreg, concentrating to form ointment, drying and sterilizing to obtain extractive; crushing the extractive and other material, sieving, mixing and granulating; sterilizing at 80 deg.c and packing as the product. The compound plant estrogen preparation can stimulate and restore female's ovary function, promote secretion of estrogen, resist oxidation, improve various senility syndromes, eliminate free radical and delay senility, and has also the functions of lowering blood fat, lowering blood pressure, etc.
Description
Technical field the present invention relates to preparation of a kind of energy delaying female aging and preparation method thereof.
Background technology estrogen is the source of woman charm, but replenishes the phytoestrogen delaying female aging, and soybean isoflavone is one of main phytoestrogen, now has been widely used in delaying female aging.But a little less than the single additional soybean isoflavone effect, be difficult to bring into play the estrogenic effect of two-ways regulation." a kind of medicament of preventing and treating Woman climacteric stage syndrome " (patent No. 92112208), announced a kind of herbal prepared rhizome of rehmannia Huang, Rhizoma Dioscoreae, Fructus Corni, Cortex Moutan, Poria, Rhizoma Alismatis, Radix Bupleuri, Radix Scutellariae, the Rhizoma Pinelliae, Radix Codonopsis, Radix Glycyrrhizae Preparata, Herba Epimedii, Semen Cuscutae, Fructus Lycii, Herba Leonuri got, batching is after decoct, filter, concentrate the medicament of making, it is definite to the treatment of climacteric syndrome, it is without any side effects to take the back, help delaying female aging, improve the quality of life of middle aged and aged women.
Summary of the invention the objective of the invention is at above-mentioned present situation, aims to provide composite plant estrogen preparation of a kind of energy delaying female aging and preparation method thereof.
The implementation of the object of the invention is, a kind of composite plant estrogen preparation of energy delaying female aging, by formulated by soybean isoflavone, Fructus Rubi, Folium Ginkgo, biological calcium carbonate, sodium iron ethylenediaminetetraacetate, Radix Puerariae isoflavone, the weight proportion of each several part is: soybean isoflavone: Fructus Rubi: Folium Ginkgo: biological calcium carbonate: sodium iron ethylenediaminetetraacetate: Radix Puerariae isoflavone=1: 24～36: 24～36: 4.8～7.2: 1.8～2.6: 1.3～1.9, wherein Chinese medicine ingredients is by crude drug weight.
A kind of preparation method of composite plant estrogen preparation of energy delaying female aging, concrete technological process is:
1) will concoct qualified Fructus Rubi, Folium Ginkgo is put into decoction pot by the required dosage of extract, adds its weight 8-10 water doubly earlier, heating decocted 2 hours, filtered, filtering residue adds 4-6 water doubly, and heating decocted 2 hours, filters, and filtering residue adds 2-3 water doubly again, heating decocted 1.5 hours, filtered
2) merge three decoction liquor, left standstill 24 hours, filter, remove slag,
3) filtrate is cooled to 4 ℃, and being concentrated into relative density is 1.25 ± 0.05, and the medicine juice amount is the clear paste of the 1/3-1/4 of former amount of filtrate,
4) with clear paste 80 ℃ of following dry disinfections 4 hours, the extract of Fructus Rubi, Folium Ginkgo,
5) in soybean isoflavone: Fructus Rubi: Folium Ginkgo: biological calcium carbonate: sodium iron ethylenediaminetetraacetate: the ratio of Radix Puerariae isoflavone=1: 24～36: 24～36: 4.8～7.2: 1.8～2.6: 1.3～1.9 adds each prescription and said extracted thing, through pulverizing, sieve, and in mixer, mixed 60 minutes
6) with the granule of mix homogeneously at 80 ℃ of following dry disinfection 2.5-3 hours, packing gets product.
Soybean isoflavone, biological calcium carbonate, sodium iron ethylenediaminetetraacetate, Radix Puerariae isoflavone and Fructus Rubi, Folium Ginkgo are pulverized, and mix 60 minutes in mixer behind 80 mesh sieves excessively.
The present invention's prescription also has following characteristics except the soybean isoflavone that delaying female aging commonly used is arranged:
1, utilize active stronger Radix Puerariae isoflavone and soybean isoflavone to form compound isoflavone, they have effects such as anti-tumor activity, estrogen activity, energy slow down aging, bring into play the estrogenic effect of two-ways regulation with this;
2, replenish biological calcium carbonate and EDTA ferrum (sodium iron ethylenediaminetetraacetate), calcium that additional needed by human body is wanted and ferrum can improve osteoporosis and the ischemia symptom that female aging causes simultaneously;
4, added Chinese medicine ingredients such as Fructus Rubi, Folium Ginkgo, can activate and recover women's ovarian function, promoted estrogen secretion, simultaneously, Folium Ginkgo extract also has effects such as blood fat reducing, blood pressure lowering, defying age, improvement sleep.
This preparation is filemot granule.This preparation can activate and recover women's ovarian function, promote estrogen secretion, replenish trace element and VitE, Vitc etc. such as the calcium of needed by human and ferrum simultaneously, can improve osteoporosis and ischemia symptom that female aging causes, can remove free radical, slow down aging also has blood fat reducing, blood pressure lowering, the anti-ageing effect of waiting for a long time.
This preparation detects through health supervision office of Hubei Province Department of Public Health, and the content of functional component is as follows:
Calcium (in Ca, %) 5.28-8.0
Ferrum (in Fe, %) 0.3-0.5
Soybean isoflavone (%) 〉=2.3
This preparation of the specific embodiment is formulated by Radix Puerariae isoflavone, soybean isoflavone, biological calcium carbonate, sodium iron ethylenediaminetetraacetate, Fructus Rubi, Folium Ginkgo, and the weight proportion of each several part is: soybean isoflavone: Fructus Rubi: Folium Ginkgo: biological calcium carbonate: sodium iron ethylenediaminetetraacetate: Radix Puerariae isoflavone=1: 24～36: 24～36: 4.8～7.2: 1.8～2.6: 1.3～1.9.
Enumerate formulation Example of the present invention below:
Example 1
Put into extraction pot with concocting qualified Fructus Rubi 240g, Folium Ginkgo 240g, add the water of 3840g earlier, heating decocted 2 hours, filtered; Filtering residue adds the water of 1920g, and heating decocted 2 hours, filters; Filtering residue adds the water of 960g again, and heating decocted 1.5 hours, filters; Merge three times and decoct filtrate, left standstill 24 hours, filter, remove slag, filtrate is cooled to 4 ℃, is concentrated into relative density and is 1.25 clear paste, clear paste 80 ℃ dry down, draw Fructus Rubi, Folium Ginkgo extract.With extract and soybean isoflavone 10g, biological calcium carbonate 48g, sodium iron ethylenediaminetetraacetate 18g, Radix Puerariae isoflavone 13g mix, pulverize, cross 80 mesh sieves, and in mixer, mixed 60 minutes, the granule of mix homogeneously at 80 ℃ of following dry disinfection 2.5-3 hours, is got product by bubble-cap, packing behind the 0.38g/ grain fill capsule.
Example 2
Preparation technology is with example 1, different is the addition of each composition, be specially: Fructus Rubi 300g, Folium Ginkgo 300g, put into extraction pot, add water: 5400g, 3000g respectively, 1500g heats decoction, extract and soybean isoflavone 10g, biological calcium carbonate 60g, sodium iron ethylenediaminetetraacetate 22g, Radix Puerariae isoflavone 16g mix.
Example 3
Preparation technology is with example 1, different is the addition of each composition, be specially: Fructus Rubi 360g, Folium Ginkgo 360g, put into extraction pot, add water: 7200g, 4320g respectively, 2160g heats decoction, extract and soybean isoflavone 10g, biological calcium carbonate 72g, sodium iron ethylenediaminetetraacetate 26g, Radix Puerariae isoflavone 19g mix.
Liyuan Hospital Attached to Tongji Medical College, Huazhong Science and Technol has carried out clinical observation with this preparation to 80 women year June in February, 2003 to 2003, and the result is reported as follows:
One, object: select the women in 30-55 year, detect its decrease in estrogen, will have symptom integral to include range of observation in 10 fens above persons.
Two, method: 80 women all take this preparation, every day 1 time, each 2 of person below 40 years old; 40～45 years old, each 3; More than 50 years old or menopause person, each 4, take before all sleeping, obeyed continuously 1 month.
Three, observation index
Observe the sings and symptoms that oestrogen deficiencies showed, observe simultaneously and take estrogen level in the blood of front and back.
The sings and symptoms that 80 routine women show and take this preparation after sings and symptoms improvement situation see the following form:
Sings and symptoms example number recovery from illness produce effects enabledisable total effective rate
n％ n％ n％ n％
Tired 62 25 40.32 17 27.41 13 20.97 7 11.29 88.71
Have a headache 36 12 33.33 10 27.78 11 30.56 3 8.33 91.67
Cardiopalmus 42 14 33.33 13 30.95 12 28.57 3 7.14 92.86
Dizzy 35 9 25.71 12 34.29 11 31.13 3 8.57 91.43
Emotional 47 13 27.66 15 31.91 14 29.79 5 10.64 89.36
Have a sleepless night 35 10 28.57 9 25.71 12 34.29 4 11.43 88.57
Melancholy, suspicion 52 12 23.08 15 28.85 18 34.62 7 13.46 86.54
Tidal fever with perspiration 65 18 27.69 25 38.46 16 24.62 6 9.23 80.77
From table, can find out that taking this preparation has obvious curative effects to the various sings and symptomses that the female estrogen hyposecretion is showed.
Conclusion is, preparation is a kind of composite plant estrogen, and it contains multiple compositions such as Radix Puerariae isoflavone, soybean isoflavone, biological calcium carbonate.Clinical practice shows that preparation can be regulated women's ovarian function, promotes estrogen secretion, simultaneously trace element and VitE, Vitc etc. such as the calcium of additional needed by human, ferrum.Various sings and symptomses such as tired, the headache due to the female estrogen deficiency, cardiopalmus, dizzy, emotional, insomnia, melancholy, upsurge perspiration, disorder of menstrual cycle, xerosis cutis pruritus all there is good efficacy.
Claims (3)
1, a kind of composite plant estrogen preparation of energy delaying female aging, it is characterized in that by soybean isoflavone, Fructus Rubi, Folium Ginkgo, biological calcium carbonate, sodium iron ethylenediaminetetraacetate, Radix Puerariae isoflavone formulated, the weight proportion of each several part is: soybean isoflavone: Fructus Rubi: Folium Ginkgo: biological calcium carbonate: sodium iron ethylenediaminetetraacetate: Radix Puerariae isoflavone=1: 24～36: 24～36: 4.8～7.2: 1.8～2.6: 1.3～1.9, wherein Chinese medicine ingredients is by crude drug weight.
2, a kind of preparation method of composite plant estrogen preparation of energy delaying female aging is characterized in that concrete technological process is:
1) will concoct qualified Fructus Rubi, Folium Ginkgo is put into decoction pot by the required dosage of extract, adds its weight 8-10 water doubly earlier, heating decocted 2 hours, filtered, filtering residue adds 4-6 water doubly, and heating decocted 2 hours, filters, and filtering residue adds 2-3 water doubly again, heating decocted 1.5 hours, filtered
2) merge three decoction liquor, left standstill 24 hours, filter, remove slag,
3) filtrate is cooled to 4 ℃, and being concentrated into relative density is 1.25 ± 0.05, and the medicine juice amount is the clear paste of the 1/3-1/4 of former amount of filtrate,
4) with clear paste 80 ℃ of following dry disinfections 4 hours, the extract of Fructus Rubi, Folium Ginkgo,
5) in soybean isoflavone: Fructus Rubi: Folium Ginkgo: biological calcium carbonate: sodium iron ethylenediaminetetraacetate: the ratio of Radix Puerariae isoflavone=1: 24～36: 24～36: 4.8～7.2: 1.8～2.6: 1.3～1.9 adds each prescription and said extracted thing, through pulverizing, sieve, and in mixer, mixed 60 minutes
6) with the granule of mix homogeneously at 80 ℃ of following dry disinfection 2.5-3 hours, packing gets product.
3, preparation method according to claim 2 is characterized in that soybean isoflavone, biological calcium carbonate, sodium iron ethylenediaminetetraacetate, Radix Puerariae isoflavone and Fructus Rubi, Folium Ginkgo pulverizing, crosses 80 mesh sieves.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 03128338 CN1207047C (en) | 2003-07-18 | 2003-07-18 | Complex plant estrogen formulation which can delay female senility and method preparing same |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 03128338 CN1207047C (en) | 2003-07-18 | 2003-07-18 | Complex plant estrogen formulation which can delay female senility and method preparing same |
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| Publication Number | Publication Date |
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| CN1481865A true CN1481865A (en) | 2004-03-17 |
| CN1207047C CN1207047C (en) | 2005-06-22 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN 03128338 Expired - Lifetime CN1207047C (en) | 2003-07-18 | 2003-07-18 | Complex plant estrogen formulation which can delay female senility and method preparing same |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101422555B (en) * | 2008-12-23 | 2011-01-05 | 武汉名实生物医药科技有限责任公司 | Formulation capable of defaecating, adjusting qi and blood, improving internal secretion and preventing senescence and preparation method |
| CN101422602B (en) * | 2008-12-08 | 2011-02-09 | 济南老来寿生物技术有限公司 | A functional food for improving women's menopausal symptoms |
| CN102524638A (en) * | 2010-12-31 | 2012-07-04 | 武汉一元堂生物科技有限公司 | Health food formula applicable for ovary maintenance, endocrine modulation, anti-oxidation and senility delay of female and method for preparing health food formula |
| CN102613550A (en) * | 2012-03-26 | 2012-08-01 | 彭锡朗 | A plant-derived food with estrogen function |
| CN103461805A (en) * | 2013-08-18 | 2013-12-25 | 青岛福加德面粉有限公司 | Flour for osteoporosis patients to eat |
-
2003
- 2003-07-18 CN CN 03128338 patent/CN1207047C/en not_active Expired - Lifetime
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101422602B (en) * | 2008-12-08 | 2011-02-09 | 济南老来寿生物技术有限公司 | A functional food for improving women's menopausal symptoms |
| CN101422555B (en) * | 2008-12-23 | 2011-01-05 | 武汉名实生物医药科技有限责任公司 | Formulation capable of defaecating, adjusting qi and blood, improving internal secretion and preventing senescence and preparation method |
| CN102524638A (en) * | 2010-12-31 | 2012-07-04 | 武汉一元堂生物科技有限公司 | Health food formula applicable for ovary maintenance, endocrine modulation, anti-oxidation and senility delay of female and method for preparing health food formula |
| CN102613550A (en) * | 2012-03-26 | 2012-08-01 | 彭锡朗 | A plant-derived food with estrogen function |
| CN103461805A (en) * | 2013-08-18 | 2013-12-25 | 青岛福加德面粉有限公司 | Flour for osteoporosis patients to eat |
| CN103461805B (en) * | 2013-08-18 | 2014-07-16 | 青岛福加德面粉有限公司 | Flour for osteoporosis patients to eat |
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| Publication number | Publication date |
|---|---|
| CN1207047C (en) | 2005-06-22 |
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Granted publication date: 20050622 |