CN1480221A - Washing free gel for disinfection - Google Patents
Washing free gel for disinfection Download PDFInfo
- Publication number
- CN1480221A CN1480221A CNA031303838A CN03130383A CN1480221A CN 1480221 A CN1480221 A CN 1480221A CN A031303838 A CNA031303838 A CN A031303838A CN 03130383 A CN03130383 A CN 03130383A CN 1480221 A CN1480221 A CN 1480221A
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- CN
- China
- Prior art keywords
- triclosan
- gel
- agent
- disinfecting gel
- thickening agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000005406 washing Methods 0.000 title abstract 2
- 238000004659 sterilization and disinfection Methods 0.000 title description 17
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 36
- XEFQLINVKFYRCS-UHFFFAOYSA-N Triclosan Chemical compound OC1=CC(Cl)=CC=C1OC1=CC=C(Cl)C=C1Cl XEFQLINVKFYRCS-UHFFFAOYSA-N 0.000 claims abstract description 30
- 229960003500 triclosan Drugs 0.000 claims abstract description 30
- 230000000249 desinfective effect Effects 0.000 claims abstract description 22
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 17
- 239000002562 thickening agent Substances 0.000 claims abstract description 16
- 239000008367 deionised water Substances 0.000 claims abstract description 13
- 229910021641 deionized water Inorganic materials 0.000 claims abstract description 13
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 6
- 238000003756 stirring Methods 0.000 claims abstract description 6
- 239000000080 wetting agent Substances 0.000 claims description 11
- 239000000203 mixture Substances 0.000 claims description 10
- 229920002125 Sokalan® Polymers 0.000 claims description 9
- USIUVYZYUHIAEV-UHFFFAOYSA-N diphenyl ether Chemical compound C=1C=CC=CC=1OC1=CC=CC=C1 USIUVYZYUHIAEV-UHFFFAOYSA-N 0.000 claims description 9
- PEDCQBHIVMGVHV-UHFFFAOYSA-N glycerol group Chemical group OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 9
- 239000003607 modifier Substances 0.000 claims description 9
- 238000002360 preparation method Methods 0.000 claims description 8
- SLINHMUFWFWBMU-UHFFFAOYSA-N Triisopropanolamine Chemical compound CC(O)CN(CC(C)O)CC(C)O SLINHMUFWFWBMU-UHFFFAOYSA-N 0.000 claims description 7
- 239000000243 solution Substances 0.000 claims description 7
- LVTYICIALWPMFW-UHFFFAOYSA-N diisopropanolamine Chemical compound CC(O)CNCC(C)O LVTYICIALWPMFW-UHFFFAOYSA-N 0.000 claims description 6
- 229940043276 diisopropanolamine Drugs 0.000 claims description 6
- 230000008961 swelling Effects 0.000 claims description 6
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 claims description 5
- 238000009472 formulation Methods 0.000 claims description 5
- 239000011259 mixed solution Substances 0.000 claims description 5
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 4
- 239000002904 solvent Substances 0.000 claims description 4
- 230000002079 cooperative effect Effects 0.000 claims description 3
- WLAMNBDJUVNPJU-UHFFFAOYSA-N 2-methylbutyric acid Chemical compound CCC(C)C(O)=O WLAMNBDJUVNPJU-UHFFFAOYSA-N 0.000 claims description 2
- 239000000159 acid neutralizing agent Substances 0.000 claims description 2
- 208000005252 hepatitis A Diseases 0.000 abstract description 4
- 201000003176 Severe Acute Respiratory Syndrome Diseases 0.000 abstract description 3
- 208000030507 AIDS Diseases 0.000 abstract 1
- 208000002672 hepatitis B Diseases 0.000 abstract 1
- 230000001954 sterilising effect Effects 0.000 description 15
- 239000000645 desinfectant Substances 0.000 description 11
- 241000725303 Human immunodeficiency virus Species 0.000 description 9
- 239000000047 product Substances 0.000 description 9
- 238000012360 testing method Methods 0.000 description 9
- 206010015150 Erythema Diseases 0.000 description 7
- 206010040880 Skin irritation Diseases 0.000 description 7
- 231100000475 skin irritation Toxicity 0.000 description 7
- 230000036556 skin irritation Effects 0.000 description 7
- 238000005303 weighing Methods 0.000 description 7
- 206010030113 Oedema Diseases 0.000 description 6
- 230000000844 anti-bacterial effect Effects 0.000 description 6
- 230000000694 effects Effects 0.000 description 6
- 231100000321 erythema Toxicity 0.000 description 6
- 238000002474 experimental method Methods 0.000 description 5
- 230000001408 fungistatic effect Effects 0.000 description 5
- 241000191967 Staphylococcus aureus Species 0.000 description 4
- 230000003385 bacteriostatic effect Effects 0.000 description 4
- 230000002354 daily effect Effects 0.000 description 4
- 208000015181 infectious disease Diseases 0.000 description 4
- LRBQNJMCXXYXIU-PPKXGCFTSA-N Chinese gallotannin Chemical compound OC1=C(O)C(O)=CC(C(=O)OC=2C(=C(O)C=C(C=2)C(=O)OC[C@@H]2[C@H]([C@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)O2)OC(=O)C=2C=C(OC(=O)C=3C=C(O)C(O)=C(O)C=3)C(O)=C(O)C=2)O)=C1 LRBQNJMCXXYXIU-PPKXGCFTSA-N 0.000 description 3
- 208000035473 Communicable disease Diseases 0.000 description 3
- 241000588724 Escherichia coli Species 0.000 description 3
- 241000700721 Hepatitis B virus Species 0.000 description 3
- 230000001154 acute effect Effects 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 230000002045 lasting effect Effects 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 244000005700 microbiome Species 0.000 description 3
- NJTGANWAUPEOAX-UHFFFAOYSA-N molport-023-220-454 Chemical compound OCC(O)CO.OCC(O)CO NJTGANWAUPEOAX-UHFFFAOYSA-N 0.000 description 3
- 230000002265 prevention Effects 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 230000002195 synergetic effect Effects 0.000 description 3
- 241001116389 Aloe Species 0.000 description 2
- 241000283973 Oryctolagus cuniculus Species 0.000 description 2
- 239000002671 adjuvant Substances 0.000 description 2
- 235000011399 aloe vera Nutrition 0.000 description 2
- 230000000845 anti-microbial effect Effects 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 239000013064 chemical raw material Substances 0.000 description 2
- 238000004140 cleaning Methods 0.000 description 2
- -1 collutory Substances 0.000 description 2
- 239000002537 cosmetic Substances 0.000 description 2
- 239000003085 diluting agent Substances 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- 238000000465 moulding Methods 0.000 description 2
- 231100000957 no side effect Toxicity 0.000 description 2
- 239000013618 particulate matter Substances 0.000 description 2
- 230000001717 pathogenic effect Effects 0.000 description 2
- 239000000546 pharmaceutical excipient Substances 0.000 description 2
- 238000007789 sealing Methods 0.000 description 2
- 239000000344 soap Substances 0.000 description 2
- 238000001228 spectrum Methods 0.000 description 2
- 239000011550 stock solution Substances 0.000 description 2
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 208000005623 Carcinogenesis Diseases 0.000 description 1
- 241000606161 Chlamydia Species 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 235000005206 Hibiscus Nutrition 0.000 description 1
- 235000007185 Hibiscus lunariifolius Nutrition 0.000 description 1
- 244000048199 Hibiscus mutabilis Species 0.000 description 1
- 235000003973 Hibiscus mutabilis Nutrition 0.000 description 1
- 244000284380 Hibiscus rosa sinensis Species 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 241000204031 Mycoplasma Species 0.000 description 1
- 241000605008 Spirillum Species 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 239000002386 air freshener Substances 0.000 description 1
- 230000002882 anti-plaque Effects 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 230000036952 cancer formation Effects 0.000 description 1
- 231100000504 carcinogenesis Toxicity 0.000 description 1
- 231100000481 chemical toxicant Toxicity 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000003750 conditioning effect Effects 0.000 description 1
- 239000004020 conductor Substances 0.000 description 1
- 230000000875 corresponding effect Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 230000008676 import Effects 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 239000010985 leather Substances 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000006210 lotion Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 230000007886 mutagenicity Effects 0.000 description 1
- 231100000299 mutagenicity Toxicity 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000000149 penetrating effect Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000033764 rhythmic process Effects 0.000 description 1
- 210000000697 sensory organ Anatomy 0.000 description 1
- 239000003206 sterilizing agent Substances 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 239000000606 toothpaste Substances 0.000 description 1
- 229940034610 toothpaste Drugs 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000820 toxicity test Toxicity 0.000 description 1
- 230000002110 toxicologic effect Effects 0.000 description 1
- 231100000027 toxicology Toxicity 0.000 description 1
- 238000009602 toxicology test Methods 0.000 description 1
Landscapes
- Cosmetics (AREA)
- Medicinal Preparation (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
A non-washing disinfecting gel for disinfecting human skin and surface of object is prepared from triclosan, alcohol, moistening agent, thickening agent, pH regulator and deionized water through dissolving triclosan in alcohol, and sequentially adding others while stirring. It can be used to prevent SARS, hepatitis A, hepatitis B, and AIDS.
Description
Technical field
The present invention relates to a kind of disinfectant, particularly a kind of disposable disinfecting gel, and it can be widely used in daily life, have good sterilization effect and the disposable disinfecting gel of lasting fungistatic effect is arranged.This disinfecting gel is with triclosan (2,4,4 '-three chloro-2 '-dihydroxy diphenyl ether) be main component, being equipped with suitable solvent, thickening agent or excipient, nertralizer and wetting agent is prepared from, can be used for sterilization, the sterilization, antibacterial of skin and body surface, the generation of prevention contact infectious disease.
Background technology
Occurring in nature extensively exists various microorganisms, and some microorganism under certain condition can be to human body and environment structure harm.The disease that is caused by cause pathogeny imcrobe infection remains one of main threat that faces in the human survival, and often there is new pathogen to find, though people have adopted the method for variety of way in antimicrobial struggle, sterilization is still the effective means of fundamental sum the most.Sterilization is meant the method for pathogenic microbe killing, is referred to as disinfectant (Disinfectants) in order to the disinfectant medicine.Because the raising of people's living standard, the enhancing of Personal hygiene and personal protection consciousness, to the requirement of sterile products and use more and more general-from being usually used in the common disinfectant of environment disinfected, to sterilization water preparation used in everyday, disinfecting gel, there has been multiple convenient and practical sterile products to come out now; Along with society and expanding economy, the quickening of people's rhythm of life, property requirement to the daily convenient articles for use that use is more and more higher, and its demand also begins to increase sharply-and wherein the disinfectant of gel dosage form has become a kind of Personal hygiene sterilizing article that is popular with its characteristics easy to use.
Efficiently, safety, wide spectrum, antimicrobial activity composition pollution-free and that can have a good compatibility with corresponding adjuvant are the first-selections of disinfecting gel preparation.Triclosan is exactly a kind of disinfectant that is widely used with these characteristics and advantage.Triclosan, chemical name 2,4,4 '-three chloro-2 '-dihydroxy diphenyl ether, it is popular in the world at present broad-spectrum high efficacy antibacterial, Gram-positive and negative bacteria, chlamydia, spirillum, mycoplasma, fungus and virus (as hepatitis A, hepatitis B virus, HIV (human immunodeficiency virus) HIV etc.) etc. are all had kill widely and inhibitory action, and have instantaneous sterilization and lasting fungistatic effect.Triclosan is the nonionic active component, good with daily use chemicals material combination commonly used, there is not acute and chronic toxic chemical compound, can induced hypersensitivity reaction, no mutagenicity and teratogenecity, non-carcinogenesis, no any optical sensibilization and photic toxicity, and do not accumulate in organ and the tissue in vivo, almost pollution-free to environment.Because the triclosan broad-spectrum kills/bacteriostasis, have simultaneously be not infected with product and skin, no any penetrating odor, to human body and Environmental security, outstanding advantage such as have no side effect, therefore be widely used as the sterilization and the bacteriostatic effective ingredient of efficient medicated soap, health fancy soap, health body lotion, anti-plaque dental care product, cleaning product, toothpaste, collutory, cosmetics, cleansing milk, air freshener, wound and medical apparatus sterilizing agent, fabric and leather sanitary finish agent etc.The product that document or patent are reported or as skin care implement (having report to contain the Aloe gel conditioning liquids of trichloro hydroxyl diphenyl ether 0.29%, ethanol, Aloe etc.) or as cleaning supplies (as US 5955408, EP0882446 etc.) or as disinfectant (as CA1245012, the gentle disinfecting gel of clean cottonrose hibiscus) as patent WO 9802137, patent US 5730963, document, but do not have to play synergistic active component.
Summary of the invention
The purpose of this invention is to provide a kind of disposable disinfecting gel, the present invention is according to the good compatibility of triclosan and number of chemical raw material, utilize ethanol and the synergistic activity of triclosan instantaneous sterilization and triclosan to continue the bacteriostatic characteristics, be developed into and have the extremely disposable gel disinfectant of bacteriostasis efficacy.The present invention can be used for sterilization, the sterilization, antibacterial of skin and body surface, the generation of prevention contact infectious disease (for example SARS, hepatitis A, hepatitis B virus, HIV (human immunodeficiency virus) HIV etc.).
The present invention is to be main effectively active component with triclosan (2,4,4 '-three chloro-2 '-dihydroxy diphenyl ether), is equipped with to comprise that medical formulation preparation forms.
The present invention includes cooperative effect agent and etoh solvent.
The present invention also comprises thickening agent carbopol 934, carbopol 940 or carbopol Ultrez-10.
The present invention also comprises acid-base modifier triisopropanolamine, triethanolamine or diisopropanolamine (DIPA); And wetting agent is a glycerol.
Composition of the present invention and mass ratio prescription: triclosan 0.05%-0.5%, ethanol 60%-70%, wetting agent 1%-5%, thickening agent 0.1%-0.5%, acid-base modifier 0.2%-0.6%, deionized water 23%-39%.
Composition of the present invention and mass ratio prescription can be: triclosan 0.1%-0.2%, ethanol 60%-70%, wetting agent 1%, thickening agent 0.2%-0.3%, acid-base modifier 0.3%-0.45%, deionized water 23%-39%.
It is the solvent and the cooperative effect agent of triclosan that the present invention selects the ethanol of high concentration for use, its concentration is up to 60-70% (mass ratio), the volume by volume concentration that is equivalent to 65-75%, triclosan was effectively dissolved, because ethanol also has good bactericidal action, also can work in coordination with the bactericidal action that realizes quick acting simultaneously with triclosan.In the preparation process of disinfecting gel, for making manufactured goods present transparent gel-form, use and to have no side effect, not have sense of discomfort, no sense organ residue, selected for use to be usually used in cosmetics and/or excipient substance is an adjuvant, comprised thickening agent or the agent of attached property, wetting agent, acid-base modifier and water.Thickening agent can be selected card wave spectrum series as 940,934, Ultrez-10 for use; For making the effective molding of gel, according to the characteristic of thickening agent, select for use suitable acid-base modifier to make the goods acid-base value suitable and meet thickening agent molding requirement, acid-base modifier can be selected triisopropanolamine, diisopropanolamine (DIPA), triethanolamine for use; Selecting glycerol for use is wetting agent, makes active component that lasting fungistatic effect be arranged.
Preparation method of the present invention is the thickening agent that accurately takes by weighing metering in proportion, swells in the deionized water of respective amount, stirs.Triclosan is dissolved in the ethanol, wetting agent solution of respective amount, adds then in the thickening agent swelling solution, be stirred to evenly; The acid-base neutralization agent that adds respective amount in the mixed solution is stirred to evenly, transparent gel-form.For making gel free from admixture, no particulate matter, goods are sub-packed in the good transparent flexible package of sealing.
The present invention utilizes ethanol and the synergistic activity of triclosan instantaneous sterilization and triclosan to continue the bacteriostatic characteristics according to the good compatibility of triclosan and number of chemical raw material, is developed into to have the disposable gel disinfectant of bacteriostasis efficacy extremely.The present invention is through killing microorganisms experiment and toxicological experiment, prove that it has the good bacteriostasis of killing, rapid-action, longer duration, various toxicology tests, on probation all meet the requirements, be comparatively ideal daily disinfectant products, can be used for sterilization, the sterilization, antibacterial of skin and body surface, the generation of prevention contact infectious disease (for example SARS, hepatitis A, hepatitis B virus, HIV (human immunodeficiency virus) HIV etc.).
When the present invention uses, directly get an amount of this gel, need not water and clean, directly smear and get final product, be applicable to a plurality of age brackets, be particularly useful for travelling, the outdoor activities personnel, as driver and conductor, archaeological work personnel, mountaineer etc.
The specific embodiment
Embodiment 1
Removing in the explanation has special showing, all proportions is mass ratio.By following formulation disinfecting gel.
Deionized water 33.05%
Carbopol (Carbopol)-Ultrez-10 0.30%
Glycerol (glycerol) 1.00%
Ethanol 65.00%
Triclosan 0.10%
Triisopropanolamine 0.45%
Under the room temperature, accurately take by weighing the carbopol-Ultrez-10 of metering in proportion, swell in the deionized water of respective amount, stir.Take by weighing required triclosan, be dissolved in the ethanol, glycerite of respective amount, it is added in the Carbopol swelling solution, be stirred to evenly; The triisopropanolamine that adds respective amount in the mixed solution is stirred to evenly, transparent gel-form.For making gel free from admixture, no particulate matter, goods are sub-packed in the good transparent flexible package of sealing.
The gel of present embodiment preparation escherichia coli, staphylococcus aureus are effectively killed, and bacteriostasis rate can reach 100%.According to GB15979-2002 " disposable use hygienic article sanitary standard ", to escherichia coli (8099) the 6th generation effect 2 minutes, it was 100% that the result shows colibacillary average bacteriostasis rate, sees Table 1 with 1: 1 diluent; Adopt this gel product stock solution, two kinds of import sample stock solutions to carry out the escherichia coli bacteriostatic test, the result proves that it has stronger bacteriostasis; According to GB15979-2002 " disposable use hygienic article sanitary standard ", to staphylococcus aureus (ATCC 6538) the 6th generation effect 2 minutes, the result showed that the average bacteriostasis rate to staphylococcus aureus is 100%, sees Table 2 with 1: 1 diluent; Through the no skin irritation test of zoopery proof, experiment is undertaken by " disinfection technology standard " (version in 2002) skin irritation test regulation, choose the male Japan large ear rabbit of 2.5-3.0kg one-level, carry out acute skin irritation test, test cropping in preceding 24 hours, after checking nothing redness, breakage before the experiment, will be tried thing 0.5ml and evenly be applied in the unhairing district, be sealed 4 hours; Remove with warm water and to be tried behind the thing to observe respectively in 1,24,48 hour dermoreaction, the integral mean value observed of different time is 0 as a result, sees Table 3, proves that this gel product does not have skin irritation.Carry out continuous skin irritation test by " disinfection technology standard " regulation, experiment is prepared the same, and continuous 14 days skin irritation, and record result show that these goods are to the skin nonirritant.
Table 1 pair colibacillary fungistatic effect
| The test sequence number | The bacteriostasis rate (%) of effect different time (min) | |||
| ????2 | ????5 | ????10 | ????20 | |
| 123 is average | ????100.00 ????100.00 ????100.00 ????100.00 | ????100.00 ????100.00 ????100.00 ????100.00 | ????100.00 ????100.00 ????100.00 ????100.00 | ????100.00 ????100.00 ????100.00 ????100.00 |
The fungistatic effect of table 2 pair staphylococcus aureus
| The test sequence number | The bacteriostasis rate (%) of effect different time (min) | |||
| ????2 | ????5 | ????10 | ????20 | |
| 123 is average | ????100.00 ????100.00 ????100.00 ????100.00 | ????100.00 ????100.00 ????100.00 ????100.00 | ????100.00 ????100.00 ????100.00 ????100.00 | ????100.00 ????100.00 ????100.00 ????100.00 |
Table 3 couple Japan large ear rabbit acute skin irritation test result
| Number of animals | Sex | Body weight Kg | ???????????????1h | ???????????????24h | ???????????????48h | |||||||||||||||
| Sample | Contrast | Sample | Contrast | Sample | Contrast | |||||||||||||||
| Erythema | Edema | Total points | Erythema | Edema | Total points | Erythema | Edema | Total points | Erythema | Edema | Total points | Erythema | Edema | Total points | Erythema | Edema | Total points | |||
| 1 | Male | 2. 8 | ?0 | ?0 | ?0 | ?0 | ?0 | ?0 | ?0 | ?0 | ?0 | ?0 | ?0 | ?0 | ?0 | ?0 | ?0 | ?0 | ?0 | ?0 |
| 2 | Male | 2. 6 | ?0 | ?0 | ?0 | ?0 | ?0 | ?0 | ?0 | ?0 | ?0 | ?0 | ?0 | ?0 | ?0 | ?0 | ?0 | ?0 | ?0 | ?0 |
| 3 | Male | 2. 8 | ?0 | ?0 | ?0 | ?0 | ?0 | ?0 | ?0 | ?0 | ?0 | ?0 | ?0 | ?0 | ?0 | ?0 | ?0 | ?0 | ?0 | ?0 |
| 4 | Male | 2. 7 | ?0 | ?0 | ?0 | ?0 | ?0 | ?0 | ?0 | ?0 | ?0 | ?0 | ?0 | ?0 | ?0 | ?0 | ?0 | ?0 | ?0 | ?0 |
| Integral mean value 0 | ||||||||||||||||||||
| Stimulus intensity classification nonirritant | ||||||||||||||||||||
Embodiment 2
By following formulation disinfecting gel.
Deionized water 28.05%
Carbopol (Carbopol)-Ultrez-10 0.30%
Glycerol (glycerol) 1.00%
Ethanol 70.00%
Triclosan 0.20%
Triisopropanolamine 0.45%
Accurately take by weighing carbopol-Ultrez-10 in proportion, swell in the deionized water of respective amount, slowly stir in the swelling process.Take by weighing required triclosan, be dissolved in the ethanol, glycerite of respective amount, it is added in the Carbopol swelling solution, be stirred to evenly; The triisopropanolamine that adds respective amount in the mixed solution is stirred to evenly, transparent gel-form.
Embodiment 3
By following formulation disinfecting gel.
Deionized water 38.3%
Carbopol 940 0.20%
Glycerol (glycerol) 1.00%
Ethanol 60%
Triclosan 0.20%
Triethanolamine 0.3%
Accurately take by weighing carbopol 940 in proportion, swell in the deionized water of respective amount, stir.Take by weighing required triclosan, be dissolved in the ethanol, glycerite of respective amount, it is added in the Carbopol swelling solution, be stirred to evenly; The triethanolamine that adds respective amount in the mixed solution is stirred to evenly, transparent gel-form.
Claims (8)
1, a kind of disposable disinfecting gel is characterized in that it is main effectively active component with triclosan (2,4,4 '-three chloro-2 '-dihydroxy diphenyl ether), is equipped with to comprise that medical formulation preparation forms.
2, disposable disinfecting gel according to claim 1 is characterized in that it comprises cooperative effect agent, etoh solvent.
3,, it is characterized in that it comprises thickening agent carbopol 934, carbopol 940 or carbopol Ultrez-10 according to the described disposable disinfecting gel of claim 1-2.
4,, it is characterized in that it comprises acid-base modifier triisopropanolamine, triethanolamine or diisopropanolamine (DIPA) according to the described disposable disinfecting gel of claim 1-3.
5,, it is characterized in that it comprises that wetting agent is a glycerol according to the described disposable disinfecting gel of claim 1-4.
6,, it is characterized in that its composition and mass ratio prescription: triclosan 0.05%-0.5%, ethanol 60%-70% according to the described disposable disinfecting gel of claim 1-5, wetting agent 1%-5%, thickening agent 0.1%-0.5%, acid-base modifier 0.2%-0.6%, deionized water 23%-39%.
7, disposable disinfecting gel according to claim 6 is characterized in that its composition and mass ratio prescription: triclosan 0.1%-0.2%, ethanol 60%-70%, wetting agent 1%, thickening agent 0.2%-0.3%, acid-base modifier 0.3%-0.45%, deionized water 23%-39%.
8, the preparation method of the described disposable disinfecting gel of claim 1 is characterized in that it is to comprise the steps: the thickening agent of metering is swollen in the deionized water, stirs; Triclosan is dissolved in ethanol, the wetting agent solution, adds then in the thickening agent swelling solution, be stirred to evenly; In mixed solution, add the acid-base neutralization agent, be stirred to even, transparent gel-form.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 03130383 CN1265842C (en) | 2003-07-09 | 2003-07-09 | Washing free gel for disinfection |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 03130383 CN1265842C (en) | 2003-07-09 | 2003-07-09 | Washing free gel for disinfection |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1480221A true CN1480221A (en) | 2004-03-10 |
| CN1265842C CN1265842C (en) | 2006-07-26 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 03130383 Expired - Fee Related CN1265842C (en) | 2003-07-09 | 2003-07-09 | Washing free gel for disinfection |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1265842C (en) |
Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN100434121C (en) * | 2005-11-18 | 2008-11-19 | 山东大学 | Antibacterial and deodorant agent for clothes and its preparation and use method |
| CN101912358A (en) * | 2010-08-12 | 2010-12-15 | 江苏爱特福84股份有限公司 | Washing-free hand disinfectant and preparation method |
| CN102210886A (en) * | 2011-06-08 | 2011-10-12 | 湖南恒邦医疗科技有限公司 | Scar removal gel composition and preparation method thereof |
| CN103239429A (en) * | 2013-04-28 | 2013-08-14 | 山东新华医疗器械股份有限公司 | Quick-dry type hand disinfection gel and preparation method thereof |
| CN104547275A (en) * | 2014-12-22 | 2015-04-29 | 合肥天一生物技术研究所 | Hand essential oil skin-care disinfection gel and preparation method thereof |
| CN105055304A (en) * | 2015-08-04 | 2015-11-18 | 河北冀衡化学股份有限公司 | Leave-on skin care and disinfection gel containing composite sterilization component, and preparation method thereof |
| CN105232355A (en) * | 2015-10-19 | 2016-01-13 | 湖北穆兰同大科技有限公司 | No-clean hand lotion and preparation method thereof |
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| CN108113942A (en) * | 2018-02-02 | 2018-06-05 | 上海哈美实业发展有限公司 | A kind of sterilization non-water hand cleanser and preparation method thereof |
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2003
- 2003-07-09 CN CN 03130383 patent/CN1265842C/en not_active Expired - Fee Related
Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100434121C (en) * | 2005-11-18 | 2008-11-19 | 山东大学 | Antibacterial and deodorant agent for clothes and its preparation and use method |
| CN101912358A (en) * | 2010-08-12 | 2010-12-15 | 江苏爱特福84股份有限公司 | Washing-free hand disinfectant and preparation method |
| CN102210886A (en) * | 2011-06-08 | 2011-10-12 | 湖南恒邦医疗科技有限公司 | Scar removal gel composition and preparation method thereof |
| CN103239429A (en) * | 2013-04-28 | 2013-08-14 | 山东新华医疗器械股份有限公司 | Quick-dry type hand disinfection gel and preparation method thereof |
| CN104547275A (en) * | 2014-12-22 | 2015-04-29 | 合肥天一生物技术研究所 | Hand essential oil skin-care disinfection gel and preparation method thereof |
| CN105055304A (en) * | 2015-08-04 | 2015-11-18 | 河北冀衡化学股份有限公司 | Leave-on skin care and disinfection gel containing composite sterilization component, and preparation method thereof |
| CN105232355A (en) * | 2015-10-19 | 2016-01-13 | 湖北穆兰同大科技有限公司 | No-clean hand lotion and preparation method thereof |
| CN105456054A (en) * | 2016-01-04 | 2016-04-06 | 保洁丽日用品(深圳)有限公司 | Water-free hand sanitizer and preparing method thereof |
| CN108113942A (en) * | 2018-02-02 | 2018-06-05 | 上海哈美实业发展有限公司 | A kind of sterilization non-water hand cleanser and preparation method thereof |
| CN109646375A (en) * | 2019-01-24 | 2019-04-19 | 合肥天生物技术研究所有限责任公司 | A kind of disposable hand-wrist bones gel and preparation method thereof |
| CN110227084A (en) * | 2019-07-04 | 2019-09-13 | 华中科技大学同济医学院附属同济医院 | Medical anti-x-ray radiation disinfecting gel and preparation method thereof |
| CN110859799A (en) * | 2019-12-03 | 2020-03-06 | 武汉康宁美生物科技有限公司 | Antibacterial gel and preparation method thereof |
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| CN1265842C (en) | 2006-07-26 |
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