CN1471845A - Health food with ganoderma lucidum and gastrodia elata as raw materials and preparation method thereof - Google Patents

Abstract

A health food with ganoderma lucidum and gastrodia elata as raw materials and a preparation method thereof, comprising 20% to 80% gastrodia elata powder and 80% to 20% ganoderma lucidum by weight percentage, drying and pulverizing the ganoderma lucidum, extracting it with 95% ethanol, Then water extraction, combined ethanol extract and water extract of Ganoderma lucidum, dried in vacuum to obtain powdered Ganoderma lucidum extract; Gastrodia elata was dried and crushed, sieved to obtain Gastrodia elata fine powder, mixed Ganoderma lucidum extract and Gastrodia elata powder, and mixed with 5 % ethanol is used as a wetting agent, granulated, granulated and then pressed into tablets; the product can improve sleep, soothe the nerves and nourish the brain. Long-term use can also promote blood supply to the brain, supply oxygen, improve intelligence, improve the symptoms of dementia, and effectively relieve emotions. Tension and anxiety, slowing down migraine attacks, and has a good comprehensive regulation and improvement effect on brain function.

Description

Health food with ganoderma lucidum and gastrodia elata as raw materials and preparation method thereof

Technical field: The present invention relates to a health food with Ganoderma lucidum and Gastrodia elata as main raw materials and a preparation method thereof.

Technical background: As we all know, with the gradual acceleration of social modernization, people feel more pressure from professional competition and life, resulting in insomnia, forgetfulness, lethargy and other health deterioration and quality of life decline It should also be more common. In medicine, sleep refers to a recurrent state of inertia and non-response, in which the level of consciousness decreases or disappears during sleep, and most physiological activities and reactions enter an inert state. Through sleep, fatigued nerve cells can be restored to normal physiological functions, and mental and physical strength can also be effectively restored. During sleep, the secretion of growth hormone in the anterior pituitary gland is significantly increased, which is beneficial to promote the growth of the body, and increase the synthesis of nuclear protein, which is beneficial to the storage of memory. And sleep disorder refers to the abnormality of sleep quantity and sleep quality or certain clinical symptoms occur during sleep, such as sleep reduction or hypersomnia, somnambulism etc. The above symptoms can lead to adverse effects such as decreased body immunity, weakened resistance to various diseases, memory loss, headaches, etc. that affect work, study and life; lead to autonomic disorders, Alzheimer's disease, and premature aging , shortened life expectancy and other serious hazards. Especially children, if lack of sleep, will affect the growth and development of body and intelligence. There are also many discussions on insomnia in traditional Chinese medicine. Traditional Chinese medicine believes that insomnia is "insomnia", also known as "can't sleep", "not to lie down", "unsightly eyes", etc. It is caused by external factors or internal injuries, etc. Dysfunction of viscera and viscera, restlessness, so that it is often difficult to fall asleep. Just as it is said in "Six Books on Febrile Diseases": "If yang is strong and yin is deficient, you will not be able to sleep day and night, and the night is dominated by yin, and if yin is strong, you will close your eyes and sleep peacefully; if yin is overwhelmed by yang, you will be disturbed all night without sleep sleep also".

With the development of society and the quickening pace of life, the incidence of insomnia is on the rise. According to statistics, about 30% of adults suffer from insomnia. As a result, insomnia is becoming a major disease that plagues human physical and mental health. The medical circle has also been making unremitting efforts for overcoming this chronic disease of the human spirit for a long time. However, although there are many types of sleep-regulating drugs or health care products currently on the market, most of them are chemically synthesized drugs, such as barbiturate sedative-hypnotics and benzodiazepine-type anti-anxiety drugs, which often cause sequelae after taking them. , and have toxic and side effects such as addiction, tolerance, easy accumulation, and influence on other physiological functions.

Summary of the invention: The present invention proposes a health food with Ganoderma lucidum and Gastrodia elata as raw materials and its preparation method. The health food is made of natural materials, and all of them are traditional Chinese medicines in my country. They can improve sleep, soothe the nerves and nourish the brain. Supply blood and oxygen to the body, improve intelligence, improve the symptoms of senile dementia, effectively relieve emotional tension and anxiety, slow down the onset of migraine, and have a good comprehensive adjustment and improvement effect on brain function, especially suitable for long-term nervous system dysfunction and anxiety-prone Stressed people improve sleep. The preparation method is simple and feasible, and is suitable for large-scale industrial production.

According to the traditional Chinese medical theory of our country, the present invention uses Gastrodia elata and Ganoderma lucidum which are calming and calming traditional Chinese medicinal materials as main raw materials.

The invention proposes a health food with ganoderma lucidum and gastrodia elata as raw materials, which is composed of 20%-80% gastrodia elata powder and 80%-20% ganoderma lucidum by weight percentage.

The Ganoderma lucidum is the extract of G. Lucidum Karst. or G. Japonicum Lloyd of the fungus of the genus Ganoderma (Ganoderma) of the Basidiomycetes Polyproraceae (Polyproraceae) or its broken spore powder or unbroken spore powder or fineness ≥ 300 mesh ultrafine powder.

A kind of preparation method as above-mentioned health food, the steps are as follows:

(1) Wash, dry and pulverize Gastrodia elata and pass through No. 6 to 9 standard sieves to obtain Gastrodia elata fine powder of no less than 100 meshes;

(2) After washing, drying and crushing the ganoderma lucidum, use 5 to 10 times the volume of edible alcohol to leaching 2 to 3 times at room temperature to 70°C, each time not less than 8 hours, separate the leaching materials, and The resulting extract is concentrated under reduced pressure at a temperature of 40-60°C to obtain a viscous extract; the medicinal material after alcohol extraction is decocted 2-3 times with 5-10 times the volume of distilled water, and the decoction time is 1-3 times each time. After 2 hours, filter out the medicinal residues, concentrate the water extract of Ganoderma lucidum at 50-60°C under reduced pressure, mix the concentrated solution with the ethanol extraction part, and then extract the residual water and ethanol in a vacuum dryer to obtain the Ganoderma lucidum extract used ;

(3) Mix Gastrodia elata powder with Ganoderma lucidum extract or its broken spore powder or unbroken spore powder or ultrafine powder with a fineness ≥ 300 mesh according to the ratio in the above formula, and then form it into capsules or tablets to obtain health food .

The above-mentioned preparation method can also wash the coarse powder of Ganoderma lucidum with 5 to 10 times the volume of 1 to 10% ammonia water for 2 to 3 times, each time not less than 8 hours, separate the extraction materials, and extract the ammonia water of Ganoderma lucidum Concentrate under reduced pressure at 50-60°C to obtain the extract, and then dry it with a vacuum dryer.

The ethanol is 60-95% edible ethanol, and is acidified with 2-5 mol/L hydrochloric acid to make the pH to 4-6.

The concentration of the dilute ammonia water is 1-10%.

The ethanol extraction of Ganoderma lucidum is carried out at room temperature to 70°C, the ammonia extraction of Ganoderma lucidum is carried out at room temperature to 60°C, and the water extraction of Ganoderma lucidum is carried out at 80°C to 100°C.

The acidified ethanol, ammonia and water extraction times are all 2 to 3 times, and each extraction with alcohol and ammonia water is not less than 8 hours, and the extraction with water is 1 to 2 hours.

The concentration and drying of the ganoderma lucidum extract are all carried out at low temperature, and the concentration temperature under reduced pressure is as follows: the alcohol extract is controlled at 30-50°C, the water extract is controlled at 40-60°C, and the vacuum drying is controlled below 60°C.

The extracts were all concentrated under reduced pressure and then dried in a vacuum dryer.

Gastrodia elata (Gastrodia elata) is a traditional precious Chinese medicinal material in my country. According to the records of "Shen Nong's Materia Medica", Gastrodia elata has the functions of suppressing convulsions, coma, and improving qi and nourishing the mind. It also has the effects of calming the liver, calming the wind and relieving spasm. Studies in recent years have also found that Gastrodia elata also has the effects of increasing intelligence, strengthening the brain, and delaying aging, and it also has certain curative effects on senile dementia. Ganoderma lucidum, also known as Wannian Mushroom, Wood Ganoderma lucidum and Ganoderma lucidum, etc., is the general name of the fungi G. Lucidum Karst. Since ancient times, it has been a precious medicinal fungus in my country. It contains a variety of biologically active ingredients. It has a stabilizing effect and can be used to treat palpitations, insomnia, forgetfulness, fatigue and other diseases. In addition to the positive synergistic effect of improving sleep, the combined application of the two has the effect of calming wind and spasm, relieving headache and dizziness, and has special curative effects on the treatment of convulsions, numbness of limbs, headache and dizziness. good medicine.

Ganoderma lucidum mainly contains biologically active components such as polysaccharides of ganoderma lucidum, ganoderma acid, adenosine and glycoprotein, which have the effects of resisting diseases, curing diseases, and prolonging life. Numerous pharmacological studies and clinical trials have proved that Ganoderma lucidum also has the following medicinal effects besides calming the nerves: anti-tumor activity, protein and nucleic acid synthesis accelerator; regulating the nervous system, eliminating the non-specific resistance of the body caused by tension; protecting the liver and Detoxification; regulation of cardiovascular system; asthmatic, antitussive, and expectorant effects of the respiratory system; immune regulation; radiation protection, so this health food is especially suitable for the long-term health care requirements of modern people.

In the present invention, according to the bioactive ingredients, pharmacological effects and clinical applications of Gastrodia elata and Ganoderma lucidum respectively, related sleep function evaluation tests have been carried out. Provide part test data of the present invention below in conjunction with embodiment:

1. Biological activity test:

1. Test material: Gastrodia elata powder: washed, dried, and pulverized Gastrodia elata medicinal material and passed through a No. 8 standard sieve; Ganoderma lucidum extract: prepared by the method described in the claims after the Ganoderma lucidum medicinal material was washed, dried, and pulverized; pentobar Sodium bital: AR, provided by Guangzhou Chemical Reagent Factory, batch number: 850601

2. Experimental animals: ordinary healthy male mice of Kunming species, provided by Kunming Institute of Zoology, Chinese Academy of Sciences, animal certificate number: Dianshidongzheng 9712.

3. Experimental method and steps:

(1) Sleep latency test: 160 mice were randomly divided into 8 groups according to body weight, 20 mice/group. The first group was given 0.1ml/10g.bw with distilled water orally (i.g); the second group was given 0.1ml/10g.bw i.g.6mg/ml gastrodia elata powder suspension; the third group was given 0.1ml/10g.bw i.g. 6mg/ml Ganoderma lucidum extract suspension; the fourth group is 0.1ml/10g.bwi.g.1mg/ml Gastrodia elata powder and 5mg/ml Ganoderma lucidum extract suspension; the fifth group is 0.1ml/10g.bw i.g.2mg/ml gastrodia elata powder and 4mg/ml ganoderma extract suspension; the sixth group is 0.1ml/10g.bw i.g.3mg/ml gastrodia elata powder and 3mg/ml ganoderma extract suspension; the seventh group is 0.1ml/10g.bw i.g.4mg/ml Gastrodia elata powder and 2mg/ml Ganoderma lucidum extract suspension; the eighth group according to 0.1ml/10g.bw i.g.5g/ml gastrodia elata powder and 1mg/ml Ganoderma lucidum extract suspension The animals in each group were fed for 15 days according to the above method, and 10-15 minutes after the feeding on the test day, the animals were injected intraperitoneally with a subhypnotic dose of pentobarbital sodium solution. Then observe the activities of the animals in each dose group and the negative control group on the hot plate at 37±2°C, and record the falling asleep rate and sleeping latency of the animals in each group (the time from the injection of pentobarbital sodium to the disappearance of the reverse reflex of the animals).

(2) Sleep time prolongation test: same as sleep latency test. A suprathreshold dose of pentobarbital sodium solution was injected intraperitoneally. The sleep duration of the animals from falling asleep (loss of righting reflex) to awakening (recovery of righting reflex) was recorded.

4. Experimental results:

Compared with the negative control group, the sleep latency test and sleep time prolongation test of the Gastrodia elata powder and Ganoderma lucidum extract group were positive, and there was a significant difference. Compared with the negative control group, the embodiment group of the present invention was positive and had very or extremely significant differences. . The experimental results can be seen in the table below.

Effects of Gastrodia elata powder and Ganoderma lucidum extract on sleep in mice (X±SD) group Gastrodia elata powder dose Ganoderma lucidum extract dose Animal sleep rate Sleep latency Sleep time (mg/kg) (mg/kg) (number of sleeping animals (min) (min)/total number of animals) Control group 1234567 0 0 4/20 12.4±3.7 17.8±9.660 0 6/20 9.8±3.5 ^# 25.7±8.9 ^# 0 60 8/20 9.3±4.2 ^# 26.1±11.2 ^# 10 50 19/20 ^*** 7.9±3.5 ^### 32.5±13.4 ^## 20 40 18/20 ^*** 8.6±3.9 ^{## 29.8±15.3 ##} 30 30 17/20 ^*** 8.4±4.5 ^## 28.3±12.5 ^{## 40} 20 17/20 ^*** 8.5 ±4.3 ^## 27.6±11.3 ^## 50 10 16/20 ^*** 9.0±3.9 ^## 27.2±10.5 ^##

* means P<0.01 compared with blank control group by x ² test; ** means P<0.05; *** means P<0.001.

# means t-test with blank control group, P<0.01; ## means P<0.05; ### means P<0.001.

2. Acute toxicity test:

1. Materials and methods: normal-grade Kunming mice, normal-grade SD sexually mature rats, provided by Kunming Institute of Zoology, Chinese Academy of Sciences, animal qualification certificate number: Dianshidongzheng 9712.

2. Test method and steps:

2.1 Acute toxicity test in mice: select 10 healthy mice weighing 23-30 g, half male and half male. The dose of the test agent was 0.6g/kg.bw, the amount of gavage was 0.2ml/10g.bw, and the gavage was administered three times continuously on an empty stomach, with an interval of 2 hours each time. The activity and death of the mice were closely observed within 4 hours after gavage. After feeding and observing for 14 days, the poisoning performance and death of the mice were recorded. 2.2 Rat acute toxicity test: select 5 healthy rats weighing 210-230 g, all male. The dose of the test substance is 0.6g/kg.bw, the amount of gavage is 1ml/100g.bw, and it is fed 5 times continuously on an empty stomach, with an interval of 2 hours each time. The activity and death of the rats are closely observed within 4 hours after gavage. Feed and observe for 14 days, and record the poisoning and death of the rats.

3. Experimental results

After the treatment of the experimental animals, the activity decreased from about 10 minutes, and the animals were quiet. During the toxicity experiment, no rats or mice died, and the general performance, body weight, weight gain, food intake and food utilization rate of the rats, hematological indicators such as : Hemoglobin (Hb), red blood cell count (RBC), white blood cell count (WBC) and classification, platelet count (PLT), etc. Blood biochemical indicators: blood sugar (GLU), triglyceride (TG), cholesterol (CHO), total protein (TP), albumin (ALB), alanine aminotransferase (ALT), aspartate aminotransferase (AST), blood urea nitrogen (BU), creatinine (CRE), etc. Organ coefficients: organ/body weight for liver, kidney, and spleen Ratio measurement, calculation of organ coefficient (organ/body weight*100), pathological examination: observe the pathological changes of the main organs of the experimental animals with the naked eye, and perform pathological histopathology on the liver, kidney, spleen and stomach, duodenum, colon, and testis The results of biopsy were normal, suggesting that in this example, Gastrodia elata powder and Ganoderma lucidum extract mixed at a ratio of 1:1 and taken directly at normal doses should be safe.

The test results show that Gastrodia elata powder and Ganoderma lucidum extract do have a certain sleep-improving effect, and the mixture of the two according to a certain ratio can have a good positive synergistic effect, and there is no adverse compatibility reaction. After being tested by human body, it has further demonstrated its clear effects of prolonging sleep time, improving sleep quality, relieving tension, and relieving migraine attacks. Moreover, the invention is made of pure natural materials, and the processing process is simple and easy, without introducing any toxic and side effects substances, nor adding any compounds, so it can be taken safely for a long time.

According to the analysis, gastrodia elata contains volatile oil, which is easy to volatilize after heating, so the customary decocting or steaming medicine method cannot make full use of its efficacy, and considering that the medicinal materials of gastrodia elata are relatively expensive, it will also cause a great waste of medicinal materials, and bring Great inconvenience. Therefore, the present invention compares Gastrodia elata extract with Gastrodia elata powder and finds that directly using Gastrodia elata fine powder as medicine can play an equivalent or synergistic effect. It can effectively reduce the cost of production, reduce the economic pressure of long-term medication, improve the compliance of taking this product, and achieve the real purpose of treatment and health care.

According to relevant research reports, Ganodenic acid contained in Ganoderma lucidum is a triterpenoid substance, which has strong pharmacological activities, such as analgesic, sedative, inhibiting the release of histamine, detoxification, liver protection, poisoning and killing tumor cells, etc. Function is one of the main components of Ganoderma lucidum, and it is also the main active component of the present invention to improve the health care effect of sleep. The present invention intends to obtain the calming and sedative effect of Ganoderma lucidum, so in the preparation process of Ganoderma lucidum extract, by using acidified ethanol (40%-95% of pH=2-4, V/V), and controlling the extraction temperature, extraction Time, to achieve the purpose of increasing the solubility of free ganoderma acid in ethanol and increasing the content of ganoderma acid in the extract. Or increase the extraction rate of ganoderma acid by leaching with alkaline water (1%-10% ammonia water). At the same time, in order to ensure product quality, low-temperature vacuum distillation and vacuum freeze-drying are used in the concentration operation after extraction. At the same time, on the basis of the experiment, it is concluded that the superfine powder of Ganoderma lucidum or the broken spore powder of Ganoderma lucidum or the unbroken spore powder of Ganoderma lucidum can also be used directly.

Specific embodiments: the present invention will be described in further detail below in conjunction with examples.

Embodiment 1

A capsule-shaped ganoderma lucidum gastrodia health food. Using ganoderma lucidum extract and Gastrodia elata powder as raw materials, the preparation method is as follows:

1. Wash Ganoderma lucidum——Ganoderma ganoderma fungus G. Lucidum Karst. of the Polyproraceae family (Polyproraceae), after washing, drying, and pulverizing, acidify with 5 times the volume of 2mol/L hydrochloric acid to a pH of about 4 to 60 % ethanol solution at 60°C for three extractions for 8 hours, 24 hours, and 48 hours respectively, combined the extracts, and distilled under reduced pressure to the extract form;

2. The filter residue of the medicinal material after alcohol extraction was decocted three times with 5 times volume of water for 1 hour, 1.5 hours, and 2 hours, respectively, and the filtrate was combined and distilled under reduced pressure to a viscous paste;

3. Merge the ethanol extract and water extract of Ganoderma lucidum, and dry it in a vacuum to obtain powdered Ganoderma lucidum extract;

4. After washing, drying and pulverizing the Gastrodia elata medicinal material, sieve it with a No. 6 standard sieve to obtain Gastrodia elata powder;

5. Mix the Ganoderma lucidum extract and Gastrodia elata powder in equal proportions (by weight), and fill the capsules.

Example 2

A capsule-shaped ganoderma lucidum gastrodia health food. Using ganoderma lucidum extract and Gastrodia elata powder as raw materials, the preparation method is as follows:

1. Ganoderma lucidum——Ganoderma ganoderma (Ganoderma) fungus G. japonicum Lloyd of the family Polyproraceae, washed, dried, and crushed, and extracted three times with 10 times the volume of 5% ammonia water at 60°C 8 hours, 24 hours, 48 hours, combine the extracts, and distill under reduced pressure to paste;

2. Vacuum drying the Ganoderma lucidum extract to obtain powdered Ganoderma lucidum extract;

3. After washing, drying and pulverizing the Gastrodia elata medicinal material, sieve it with a No. 6 standard sieve to obtain Gastrodia elata powder;

4. Mix the Ganoderma lucidum extract and Gastrodia elata powder in equal proportions (by weight), and fill the capsules.

Example 3

A tablet-shaped ganoderma lucidum health food. Using ganoderma lucidum extract and Gastrodia elata powder as raw materials, the preparation method is as follows:

1. Wash Ganoderma lucidum——Polyproraceae (Polyproraceae) Ganoderma (Ganoderma) fungus G. Lucidum Karst. After washing, drying, and pulverizing, acidify with 5 times the volume of 5mol/L hydrochloric acid until the pH is about The 95% ethanol solution of 5 was extracted three times at 60°C for 8 hours, 24 hours, and 48 hours respectively, and the extracts were combined and distilled under reduced pressure to a paste;

2. After the alcohol extraction, the filter residue of the medicinal material is then distilled with 5 times the volume of water for three times and decocted for 1 hour, 1.5 hours, and 2 hours respectively, and the filtrate is combined and distilled under reduced pressure to a viscous paste;

3. Merge the ethanol extract and water extract of Ganoderma lucidum, and dry in a vacuum to obtain powdered Ganoderma lucidum extract;

4. After washing, drying and pulverizing the Gastrodia elata medicinal material, sieve it with No. 9 pharmacopoeia standard sieve to obtain Gastrodia elata fine powder;

5. Mix the Ganoderma lucidum extract and Gastrodia elata powder in equal proportions (by weight), use 5% ethanol as a wetting agent, pass through a No. 4 standard pharmacopoeia sieve, granulate, granulate and then compress into tablets.

Example 4

A tablet-shaped ganoderma lucidum health food. Using gastrodia elata powder and Ganoderma lucidum superfine powder as raw materials, the preparation method is as follows:

1. After washing, drying and pulverizing the Gastrodia elata medicinal material, sieve it with the No. 9 pharmacopoeia standard sieve to obtain Gastrodia elata fine powder;

2, get Gastrodia elata fine powder and fineness ≥ 300 order Ganoderma lucidum---the superfine powder equal ratio (weight ratio) of Basidiomycetes Polyproraceae (Polyproraceae) Ganoderma (Ganoderma) fungus G.Japonicum Lloyd mixes evenly, with 5 % ethanol as a wetting agent, pass through No. 4 standard pharmacopoeia sieve to granulate, granulate and then compress into tablets. The health food prepared in the above examples all shows that there are significant effects such as improving sleep, alleviating tension and anxiety, headache and dizziness through human body test.

Claims (10)

1. A health food with ganoderma lucidum and gastrodia elata as raw materials, which is composed of 20%-80% gastrodia elata powder and 80%-20% ganoderma lucidum by weight percentage. 2. The Ganoderma lucidum described in claim 1 is the extract of G. Lucidum Karst. or G. Japonicum Lloyd, or its broken spore powder or unbroken wall, of the fungus of the genus Ganoderma (Ganoderma) of the family Polyproraceae. Spore powder or ultrafine powder with fineness ≥300 mesh. 3. A method for preparing health food as claimed in claim 1, the steps are as follows: (1) Wash, dry and pulverize Gastrodia elata and pass through No. 6 to 9 standard sieves to obtain Gastrodia elata fine powder of no less than 100 meshes; (2) After washing, drying and crushing the ganoderma lucidum, use 5 to 10 times the volume of edible alcohol to leaching 2 to 3 times at room temperature to 70°C, each time not less than 8 hours, separate the leaching materials, and The resulting extract is concentrated under reduced pressure at a temperature of 40-60°C to obtain a viscous extract; the medicinal material after alcohol extraction is decocted 2-3 times with 5-10 times the volume of distilled water, and the decoction time is 1-3 times each time. After 2 hours, filter out the medicinal residues, concentrate the water extract of Ganoderma lucidum at 50-60°C under reduced pressure, mix the concentrated solution with the ethanol extraction part, and then extract the residual water and ethanol in a vacuum dryer to obtain the Ganoderma lucidum extract used ; (3) Mix Gastrodia elata powder with Ganoderma lucidum extract or its broken spore powder or unbroken spore powder or ultrafine powder with a fineness ≥ 300 mesh according to the ratio in the above formula, and then form it into capsules or tablets to obtain health food . 4. The preparation method according to claim 2, characterized in that the washed Ganoderma lucidum powder can also be leached with 5-10 times the volume of 1-10% ammonia water for 2-3 times, each time not less than 8 hours , separate the extraction materials, concentrate the ammonia water extract of Ganoderma lucidum at 50-60°C under reduced pressure to obtain an extract, and then dry it with a vacuum dryer. 5. The preparation method according to claim 2, characterized in that the ethanol used is 60-95% edible ethanol, and is acidified with 2-5 mol/L hydrochloric acid to make the pH to 4-6. 6. The preparation method according to claim 3, characterized in that the concentration of dilute ammonia water used is 1-10%. 7. The preparation method according to claim 2 or 3, characterized in that the alcohol extraction of Ganoderma lucidum is carried out at room temperature to 70°C, the ammonia extraction of Ganoderma lucidum is carried out at room temperature to 60°C, and the water extraction of Ganoderma lucidum is carried out at 80°C to 100°C. 8. The preparation method according to claim 2 or 3, characterized in that the extraction times of acidified ethanol, ammonia water, and water are 2-3 times, and the extraction time of alcohol and ammonia water is not less than 8 hours each time, and the extraction time of water extraction is 1-3 times. 2 hours. 9. The preparation method according to claim 2, characterized in that the concentration and drying of the ganoderma lucidum extract is carried out at low temperature, and the concentration temperature under reduced pressure is: the alcohol extract is controlled at 30-50°C, and the water extract is controlled at 40-60°C. ℃, vacuum drying is controlled below 60 ℃. 10. The preparation method according to claim 2, characterized in that the extracts are all concentrated under reduced pressure and then dried in a vacuum dryer.