CN1470288A - Medical use of paramagnetic material - Google Patents
Medical use of paramagnetic material Download PDFInfo
- Publication number
- CN1470288A CN1470288A CNA021142955A CN02114295A CN1470288A CN 1470288 A CN1470288 A CN 1470288A CN A021142955 A CNA021142955 A CN A021142955A CN 02114295 A CN02114295 A CN 02114295A CN 1470288 A CN1470288 A CN 1470288A
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- CN
- China
- Prior art keywords
- paramagnetic material
- paramagnetic
- nanoscale
- medicine
- tumor
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000002907 paramagnetic material Substances 0.000 title claims abstract description 49
- 230000000694 effects Effects 0.000 claims abstract description 22
- 239000003814 drug Substances 0.000 claims abstract description 20
- 210000004881 tumor cell Anatomy 0.000 claims abstract description 15
- 206010028980 Neoplasm Diseases 0.000 claims description 35
- 238000011282 treatment Methods 0.000 claims description 28
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims description 25
- 238000001959 radiotherapy Methods 0.000 claims description 14
- 210000004204 blood vessel Anatomy 0.000 claims description 13
- 201000010099 disease Diseases 0.000 claims description 12
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 12
- 230000005291 magnetic effect Effects 0.000 claims description 12
- 210000000936 intestine Anatomy 0.000 claims description 9
- 210000002784 stomach Anatomy 0.000 claims description 9
- 230000001133 acceleration Effects 0.000 claims description 7
- 230000008901 benefit Effects 0.000 claims description 7
- 230000003013 cytotoxicity Effects 0.000 claims description 7
- 231100000135 cytotoxicity Toxicity 0.000 claims description 7
- 230000012010 growth Effects 0.000 claims description 7
- 239000003431 cross linking reagent Substances 0.000 claims description 6
- 230000003902 lesion Effects 0.000 claims description 3
- 239000004531 microgranule Substances 0.000 claims description 2
- -1 ferrum chemical compound Chemical class 0.000 claims 3
- 230000005408 paramagnetism Effects 0.000 abstract description 3
- 230000005298 paramagnetic effect Effects 0.000 abstract description 2
- 230000005389 magnetism Effects 0.000 abstract 2
- 239000002245 particle Substances 0.000 abstract 2
- 230000005855 radiation Effects 0.000 description 9
- 238000002560 therapeutic procedure Methods 0.000 description 9
- 210000004027 cell Anatomy 0.000 description 8
- 238000002512 chemotherapy Methods 0.000 description 6
- 229910052742 iron Inorganic materials 0.000 description 6
- 238000000034 method Methods 0.000 description 4
- 201000011510 cancer Diseases 0.000 description 3
- 230000001225 therapeutic effect Effects 0.000 description 3
- 230000005283 ground state Effects 0.000 description 2
- PXFBZOLANLWPMH-UHFFFAOYSA-N 16-Epiaffinine Natural products C1C(C2=CC=CC=C2N2)=C2C(=O)CC2C(=CC)CN(C)C1C2CO PXFBZOLANLWPMH-UHFFFAOYSA-N 0.000 description 1
- 239000000427 antigen Substances 0.000 description 1
- 102000036639 antigens Human genes 0.000 description 1
- 108091007433 antigens Proteins 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000006735 deficit Effects 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000000004 hemodynamic effect Effects 0.000 description 1
- 230000002607 hemopoietic effect Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000002638 palliative care Methods 0.000 description 1
- 230000002285 radioactive effect Effects 0.000 description 1
- 230000003439 radiotherapeutic effect Effects 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 230000000284 resting effect Effects 0.000 description 1
- 239000003998 snake venom Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 230000004614 tumor growth Effects 0.000 description 1
Landscapes
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
The invention discloses a kind of paramagnetic material and the application in medicine. The paramagnetic material is produced into particle or nano grade, so it has fluidity and paramagnetism, it can locate and assemble onto the focus area precisely and cure the focus by the magnetism field after contacting with other medicine. The paramagnetic material is radiated by atomic energy or accelerated by accelerator to attach the core and cause the reaction, so the paramagnetic material turns into radiant particle or nano paramagnetic nuclear element, it can locate the focus through the use of magnetism field, and takes effect on the focus, and kills the tumour cell when they are in division period.
Description
Technical field
The present invention relates to a kind of new purposes of paramagnetic material, particularly in pharmaceutically application.
Background technology
Tumor treatment has only three kinds of methods, the one, operative treatment, the 2nd, chemotherapy, the 3rd, X-ray therapy at present.No matter which kind of method all has the scope of its indication and requirement, and all have its side effect, particularly chemotherapy and radiation very big to the side effect that the patient brings, its common side effect is all not have very high specificity and than accurate in locating.In killing tumor cell, also normal cell is killed, even the hemopoietic system of whole body is had severe impairment, make it when using radiation and chemotherapy, to make patient pay very big cost.Radiation and chemotherapy is done the time spent to tumor cell all its sensitive period in when division, have only when tumor cell during in sensitive period, its radiation and chemotherapy just has its effect, and the growth of tumor cell is in different times, particularly in resting stage, do not act on basically, this carries out radiation and chemotherapy to patient incessantly with regard to needs and to the full extent tumor cell is killed with assurance, like this, normal cell also is damaged.Radiotherapist is an emerge science that grows up.Particularly over nearly more than 20 years along with the development of modern high technology and popularizing of precision instrument, radiotherapist obtains to develop rapidly, one of main means of treatment malignant tumor have been become, there is the malignant tumor about 70% to need radiotherapy (comprising Comprehensive Treatment and palliative treatment) approximately, radiotherapy plays a part can not be ignored in tumor therapeutic procedure, and its curative effect is confirmed by clinical practice.In radiotherapy development, we should see the problem and shortage that its exists, and how when protecting normal structure, the therapeutic effect that improves local tumor tissues has become urgent problem in the oncotherapy as far as possible.People always wish to find the localized medicine of a kind of energy that tumor cell is accurately killed, no matter be antigen-antibody, phytohaemagglutinin, snake venom or the like, wish to find the specific antigen of tumor and the affinity substance of tumor, carry out the guided missile therapy with sign as tumor, but owing to be difficult to find very high specific affine material in tumor cell and the normal cell, tumor guided missile therapy system is fluctuated always, do not have breakthrough.To the treatment of local tumor tissues, effect is preferably interventional therapy at present.And interventional therapy is that the therapeutic radiation isotope is injected in the cancerous cell blood vessel, by lonizing radiation the radiation of cancerous cell is killed or is killed and wounded, and reaches the purpose of treatment cancer, and its effect is better than whole body irradiation radiation treatment method.But because the cancerous cell blood vessel is abundant, these radiosiotope may be transferred to other positions of health with blood circulation, and at these positions normal cell is radiated, kill and wound normal cell, so not only reduced therapeutic effect to former focus, simultaneously cause other positions injured again, also may bring other side effect.Existing interventional therapy also exists a problem simultaneously, that be exactly employed radiosiotope all be long radiosiotope of some half-life, thereby the time that stops in human body is long, having injected these radioisotopic patients like this is exactly a dangerous matter sources, and the crowd around can giving works the mischief.Moreover the element of getting back to ground state after the decay of these radiosiotope be not human body do not need, or requirement is little, the element of getting back to ground state so after the decay of these radiosiotope rests in the human body for a long time, and that can give the people equally healthyly causes some side effect.Development along with nanotechnology, many nanoscale paramagnetic materials all come out by the whole bag of tricks is manufactured, these nanometer paramagnetic materials have changed raw-material separately physical characteristic, has flowability, they can be injected in the blood vessel with some suspensions, it be distributed in the blood vessel by hemodynamic.Simultaneously because these nanometer paramagnetic materials have paramagnetism, can be under the effect of external magnetic field the directed a certain position that accumulate in human body, thereby be that the locating therapy of disease, particularly tumor provides a kind of new method.
Summary of the invention
The objective of the invention is to utilize the flowability and the paramagnetic characteristics of nanometer paramagnetic material, and provide these paramagnetic materials in pharmaceutically application, realizing to some disease, the locating therapy of tumor particularly.
These paramagnetic materials comprise in application pharmaceutically:
1, make microgranular these paramagnetic materials or nanoscale, on these microgranule paramagnetic materials, adopt the medicine of crosslinked other treatment disease of cross-linking agent, clothes go in the intestines and stomach or inject the effect of blood vessel by externally-applied magnetic field to make it orientation and accumulate in by treatment lesion tissue zone, the medicine that disease is treated.
2, make microgranular these paramagnetic materials or nanoscale, make these paramagnetic materials become the granular or nanoscale paramagnetic material nucleic of radiological predication fallout plot through atomic energy irradiation or accelerator acceleration electrochondria in order to the nuclear reaction that the bombardment target nucleus causes, granular or nanoscale paramagnetic material nucleic is obeyed in the intestines and stomach or is injected blood vessel with these radiological predication fallout plots, effect by externally-applied magnetic field makes it accurately to navigate to by treatment focus (tumor tissues) zone, long period act on tumor cell or tumor tissues, with tumor cytotoxicity at the growth radiotherapy medicine of splitted sensitive period.
3, make microgranular these paramagnetic materials or nanoscale, make these paramagnetic materials become the granular or nanoscale paramagnetic material nucleic of radiological predication fallout plot through atomic energy irradiation or accelerator acceleration electrochondria in order to the nuclear reaction that the bombardment target nucleus causes, adopt the medicine of crosslinked other treatment disease of cross-linking agent on the granular or nanoscale paramagnetic material nucleic at these radiological predication fallout plots, clothes go in the intestines and stomach or inject the effect of blood vessel by externally-applied magnetic field to make it accurately to navigate to by treatment focus (tumor tissues) zone, long period act on tumor cell or tumor tissues, with tumor cytotoxicity at growth radiotherapy and the treatment economic benefits and social benefits medicine of splitted sensitive period.
Since above-mentioned paramagnetic material be made into microgranular or nanoscale after, have flowability and paramagnetism, behind medicine of crosslinked upward other treatment disease, thereby can be under the effect of external magnetic field, accurately locate and gather focus (tumor tissues) zone, focus (tumor tissues) is treated.These microgranular or nano level paramagnetic materials make these paramagnetic materials become the granular or nanoscale paramagnetic material nucleic of radiological predication fallout plot through atomic energy irradiation or accelerator acceleration electrochondria in order to the nuclear reaction that the bombardment target nucleus causes in addition, under the effect by external magnetic field, accurately navigate to focus (tumor tissues) zone, long period act on tumor cell or tumor tissues, with tumor cytotoxicity in growth splitted sensitive period.Therefore the present invention has the advantage that can position treatment and radiotherapy to focus (tumor) tissue, and treatment and radiotherapeutic effect are good, and medical expense is low.
Concrete true mode
Paramagnetic material is as Fe
2O
3Comprise in pharmaceutically application:
1, with Fe
2O
3Make microgranular or nanoscale, at microgranular Fe
2O
3The medicine of crosslinked other treatment disease of last employing cross-linking agent, clothes go in the intestines and stomach or inject the effect of blood vessel by externally-applied magnetic field to make it orientation and accumulate in by treatment lesion tissue zone, the medicine that disease is treated.
2, with Fe
2O
3Make microgranular or nanoscale, make Fe in order to the nuclear reaction that the bombardment target nucleus causes through atomic energy irradiation or accelerator acceleration electrochondria
2O
3Become the granular or nano-level iron nucleic of radiological predication fallout plot, granular or nano-level iron nucleic is obeyed in the intestines and stomach or is injected blood vessel with radiological predication fallout plot, effect by externally-applied magnetic field makes it accurately to navigate to by treatment focus (tumor tissues) zone, long period act on tumor cell or tumor tissues, with tumor cytotoxicity at the growth radiotherapy medicine of splitted sensitive period.
3, with Fe
2O
3Make microgranular or nanoscale, make Fe in order to the nuclear reaction that the bombardment target nucleus causes through atomic energy irradiation or accelerator acceleration electrochondria
2O
3Become the granular or nano-level iron nucleic of radiological predication fallout plot, adopt the medicine of crosslinked other treatment disease of cross-linking agent on the granular or nano-level iron nucleic at radiological predication fallout plot, clothes go in the intestines and stomach or inject the effect of blood vessel by externally-applied magnetic field to make it accurately to navigate to by treatment focus (tumor tissues) zone, long period act on tumor cell or tumor tissues, with tumor cytotoxicity at growth radiotherapy and the treatment economic benefits and social benefits medicine of splitted sensitive period.
Because the paramagnetic material that present embodiment adopts is microgranular or nano-level iron, the half-life of its radioactive nano ferrum nucleic is shorter, has only 46～48 days, after its half-life, and F
56Can be utilized by human body and radiate, as the iron supplement drug use.
Above-mentioned paramagnetic material can also for the chemical compound of ferrum and other ferrum,
Claims (6)
1, a kind of paramagnetic material is in pharmaceutically application, it is characterized in that making microgranular these paramagnetic materials or nanoscale, on these microgranule paramagnetic materials, adopt the medicine of crosslinked other treatment disease of cross-linking agent, clothes go in the intestines and stomach or inject the effect of blood vessel by externally-applied magnetic field to make it orientation and accumulate in by treatment lesion tissue zone, the medicine that disease is treated.
2, a kind of paramagnetic material is in pharmaceutically application, it is characterized in that making microgranular these paramagnetic materials or nanoscale, make these paramagnetic materials become the granular or nanoscale paramagnetic material nucleic of radiological predication fallout plot through atomic energy irradiation or accelerator acceleration electrochondria in order to the nuclear reaction that the bombardment target nucleus causes, granular or nanoscale paramagnetic material nucleic is obeyed in the intestines and stomach or is injected blood vessel with these radiological predication fallout plots, effect by externally-applied magnetic field makes it accurately to navigate to by treatment focus (tumor tissues) zone, long period act on tumor cell or tumor tissues, with tumor cytotoxicity at the growth radiotherapy medicine of splitted sensitive period.
3, a kind of paramagnetic material is in pharmaceutically application, it is characterized in that making microgranular these paramagnetic materials or nanoscale, make these paramagnetic materials become the granular or nanoscale paramagnetic material nucleic of radiological predication fallout plot through atomic energy irradiation or accelerator acceleration electrochondria in order to the nuclear reaction that the bombardment target nucleus causes, adopt the medicine of crosslinked other treatment disease of cross-linking agent on the granular or nanoscale paramagnetic material nucleic at these radiological predication fallout plots, clothes go in the intestines and stomach or inject the effect of blood vessel by externally-applied magnetic field to make it accurately to navigate to by treatment focus (tumor tissues) zone, long period act on tumor cell or tumor tissues, with tumor cytotoxicity at growth radiotherapy and the treatment economic benefits and social benefits medicine of splitted sensitive period.
4, a kind of paramagnetic material according to claim 1 is in pharmaceutically application, it is characterized in that described paramagnetic material be ferrum and ferrum chemical compound,
5, a kind of paramagnetic material according to claim 2 is in pharmaceutically application, it is characterized in that described paramagnetic material be ferrum and ferrum chemical compound,
6, a kind of paramagnetic material according to claim 3 is in pharmaceutically application, it is characterized in that described paramagnetic material be ferrum and ferrum chemical compound,
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA021142955A CN1470288A (en) | 2002-07-24 | 2002-07-24 | Medical use of paramagnetic material |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA021142955A CN1470288A (en) | 2002-07-24 | 2002-07-24 | Medical use of paramagnetic material |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1470288A true CN1470288A (en) | 2004-01-28 |
Family
ID=34142011
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA021142955A Pending CN1470288A (en) | 2002-07-24 | 2002-07-24 | Medical use of paramagnetic material |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1470288A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006069481A1 (en) * | 2004-12-29 | 2006-07-06 | Beijing Institute Of Transfusion Medicine | Target enrichment method of stem cells and magnetic enrichment device for target localization |
| CN107224581A (en) * | 2017-05-18 | 2017-10-03 | 常州大学 | A kind of method that airway mucus viscosity is reduced based on field drives paramagnetic nanoparticle |
| CN108456670A (en) * | 2017-02-21 | 2018-08-28 | 中国科学院生物物理研究所 | Application of the magnetically confined equipment in preparing the product for adjuvant chemotherapy |
-
2002
- 2002-07-24 CN CNA021142955A patent/CN1470288A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006069481A1 (en) * | 2004-12-29 | 2006-07-06 | Beijing Institute Of Transfusion Medicine | Target enrichment method of stem cells and magnetic enrichment device for target localization |
| CN108456670A (en) * | 2017-02-21 | 2018-08-28 | 中国科学院生物物理研究所 | Application of the magnetically confined equipment in preparing the product for adjuvant chemotherapy |
| CN107224581A (en) * | 2017-05-18 | 2017-10-03 | 常州大学 | A kind of method that airway mucus viscosity is reduced based on field drives paramagnetic nanoparticle |
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| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |