CN1449794A - Radix bupleuri soft capsule pharmaceutics and preparation process thereof - Google Patents
Radix bupleuri soft capsule pharmaceutics and preparation process thereof Download PDFInfo
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- CN1449794A CN1449794A CN 03116422 CN03116422A CN1449794A CN 1449794 A CN1449794 A CN 1449794A CN 03116422 CN03116422 CN 03116422 CN 03116422 A CN03116422 A CN 03116422A CN 1449794 A CN1449794 A CN 1449794A
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- Prior art keywords
- radix bupleuri
- soft capsule
- bupleurum root
- volatile oil
- extract
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- 239000007901 soft capsule Substances 0.000 title claims abstract description 18
- 238000002360 preparation method Methods 0.000 title claims abstract description 15
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 50
- 239000000341 volatile oil Substances 0.000 claims abstract description 20
- 241000202726 Bupleurum Species 0.000 claims abstract description 16
- 235000011187 glycerol Nutrition 0.000 claims abstract description 14
- 239000007788 liquid Substances 0.000 claims abstract description 11
- 108010010803 Gelatin Proteins 0.000 claims abstract description 10
- 239000008273 gelatin Substances 0.000 claims abstract description 10
- 229920000159 gelatin Polymers 0.000 claims abstract description 10
- 235000019322 gelatine Nutrition 0.000 claims abstract description 10
- 235000011852 gelatine desserts Nutrition 0.000 claims abstract description 10
- 239000002904 solvent Substances 0.000 claims abstract description 10
- 239000003381 stabilizer Substances 0.000 claims abstract description 9
- 238000000034 method Methods 0.000 claims abstract description 5
- 239000000284 extract Substances 0.000 claims description 22
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 15
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims description 9
- WVDDGKGOMKODPV-UHFFFAOYSA-N Benzyl alcohol Chemical compound OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 claims description 6
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 claims description 6
- 238000001035 drying Methods 0.000 claims description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 6
- 239000004480 active ingredient Substances 0.000 claims description 5
- 230000002421 anti-septic effect Effects 0.000 claims description 5
- 238000000194 supercritical-fluid extraction Methods 0.000 claims description 5
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims description 4
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims description 4
- 229920000053 polysorbate 80 Polymers 0.000 claims description 4
- 238000003756 stirring Methods 0.000 claims description 4
- 239000002202 Polyethylene glycol Substances 0.000 claims description 3
- 239000001569 carbon dioxide Substances 0.000 claims description 3
- 229910002092 carbon dioxide Inorganic materials 0.000 claims description 3
- 239000000084 colloidal system Substances 0.000 claims description 3
- 235000021050 feed intake Nutrition 0.000 claims description 3
- 229920001223 polyethylene glycol Polymers 0.000 claims description 3
- 239000000843 powder Substances 0.000 claims description 3
- 239000013557 residual solvent Substances 0.000 claims description 3
- 238000001256 steam distillation Methods 0.000 claims description 3
- 239000005711 Benzoic acid Substances 0.000 claims description 2
- MOZDKDIOPSPTBH-UHFFFAOYSA-N Benzyl parahydroxybenzoate Chemical compound C1=CC(O)=CC=C1C(=O)OCC1=CC=CC=C1 MOZDKDIOPSPTBH-UHFFFAOYSA-N 0.000 claims description 2
- QFOHBWFCKVYLES-UHFFFAOYSA-N Butylparaben Chemical compound CCCCOC(=O)C1=CC=C(O)C=C1 QFOHBWFCKVYLES-UHFFFAOYSA-N 0.000 claims description 2
- 235000010233 benzoic acid Nutrition 0.000 claims description 2
- 235000019445 benzyl alcohol Nutrition 0.000 claims description 2
- 238000007796 conventional method Methods 0.000 claims description 2
- 229960001617 ethyl hydroxybenzoate Drugs 0.000 claims description 2
- 239000004403 ethyl p-hydroxybenzoate Substances 0.000 claims description 2
- 235000010228 ethyl p-hydroxybenzoate Nutrition 0.000 claims description 2
- NUVBSKCKDOMJSU-UHFFFAOYSA-N ethylparaben Chemical compound CCOC(=O)C1=CC=C(O)C=C1 NUVBSKCKDOMJSU-UHFFFAOYSA-N 0.000 claims description 2
- 229960005150 glycerol Drugs 0.000 claims description 2
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 claims description 2
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 claims description 2
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 claims description 2
- 229960002216 methylparaben Drugs 0.000 claims description 2
- GJLNWLVPAHNBQN-UHFFFAOYSA-N phenyl 4-hydroxybenzoate Chemical compound C1=CC(O)=CC=C1C(=O)OC1=CC=CC=C1 GJLNWLVPAHNBQN-UHFFFAOYSA-N 0.000 claims description 2
- 239000004405 propyl p-hydroxybenzoate Substances 0.000 claims description 2
- 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 claims description 2
- 229960004063 propylene glycol Drugs 0.000 claims description 2
- 235000013772 propylene glycol Nutrition 0.000 claims description 2
- QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 claims description 2
- 235000015112 vegetable and seed oil Nutrition 0.000 claims description 2
- 239000008158 vegetable oil Substances 0.000 claims description 2
- 239000003814 drug Substances 0.000 abstract description 7
- 239000002775 capsule Substances 0.000 abstract description 5
- 239000009849 Bupleurum root extract Substances 0.000 abstract 1
- 238000004090 dissolution Methods 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 239000003755 preservative agent Substances 0.000 abstract 1
- 230000002335 preservative effect Effects 0.000 abstract 1
- 238000003825 pressing Methods 0.000 abstract 1
- 238000005516 engineering process Methods 0.000 description 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
- 239000002552 dosage form Substances 0.000 description 4
- 229940079593 drug Drugs 0.000 description 4
- 239000000706 filtrate Substances 0.000 description 4
- 230000000694 effects Effects 0.000 description 3
- 239000007787 solid Substances 0.000 description 3
- JLPULHDHAOZNQI-ZTIMHPMXSA-N 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCC\C=C/C\C=C/CCCCC JLPULHDHAOZNQI-ZTIMHPMXSA-N 0.000 description 2
- 239000001856 Ethyl cellulose Substances 0.000 description 2
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 description 2
- 206010037660 Pyrexia Diseases 0.000 description 2
- 102000011759 adducin Human genes 0.000 description 2
- 108010076723 adducin Proteins 0.000 description 2
- 239000007766 cera flava Substances 0.000 description 2
- 235000019325 ethyl cellulose Nutrition 0.000 description 2
- 229920001249 ethyl cellulose Polymers 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 238000009413 insulation Methods 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 210000000582 semen Anatomy 0.000 description 2
- 229940083466 soybean lecithin Drugs 0.000 description 2
- 208000019255 Menstrual disease Diseases 0.000 description 1
- 206010050819 Musculoskeletal chest pain Diseases 0.000 description 1
- 229920002565 Polyethylene Glycol 400 Polymers 0.000 description 1
- 229910000831 Steel Inorganic materials 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 230000001754 anti-pyretic effect Effects 0.000 description 1
- 239000002221 antipyretic Substances 0.000 description 1
- 239000004359 castor oil Substances 0.000 description 1
- 235000019438 castor oil Nutrition 0.000 description 1
- 238000007872 degassing Methods 0.000 description 1
- UGMCXQCYOVCMTB-UHFFFAOYSA-K dihydroxy(stearato)aluminium Chemical compound CCCCCCCCCCCCCCCCCC(=O)O[Al](O)O UGMCXQCYOVCMTB-UHFFFAOYSA-K 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000001125 extrusion Methods 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 239000003292 glue Substances 0.000 description 1
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 1
- 150000002333 glycines Chemical class 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000000465 moulding Methods 0.000 description 1
- JLFNLZLINWHATN-UHFFFAOYSA-N pentaethylene glycol Chemical compound OCCOCCOCCOCCOCCO JLFNLZLINWHATN-UHFFFAOYSA-N 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 239000010959 steel Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Abstract
The present invention relates to a Radix bupleuri soft capsule oral medicine preparation and its preparation method. The liquid medicine contains bupleurum root extract and volatile oil of bupleurum root, solvent and stabilizing agent. The mixing ratio of gelatin and glycerin in the capsule shell is (weight ratio) 10:3.15-3.35 and the preservative also can be contained. When it is prepared, firstly, the volatile oil of bupleurum root can be extracted, then pressing process is adopted to make the above-mentioned materials into soft capsule. Said invention has the advantages of stable quality, convenient for carry about and administration and quick dissolution of effective component.
Description
Technical field
The invention belongs to medical technical field, be specifically related to a kind of bupleurum root medicinal preparation,, the invention still further relates to the preparation method of said preparation simultaneously more specifically to a kind of bupleurum root soft capsule.
Background technology
The dry root of the medicinal umbelliferae bupleurum of Radix Bupleuri, Radix Bupleuri has the effect of " reconciling superficies and interior, soothing liver-QI, yang invigorating " on the Chinese medicine, is used for the treatment of cold, fever, alternate attack of chill and fever, sternal rib pain, diseases such as menoxenia.The preparation of Radix Bupleuri mainly contains injection and oral liquid clinically.The curative effect of injection can be affirmed, still has the shortcoming of medication inconvenience; Though oral liquid technology is simple, cost is low, and the quality instability is easy to generate precipitation, and carries transportation inconvenience.Saikoside in the Radix Bupleuri extract and Radix Bupleuri volatile oil all have the effect of antiinflammatory antipyretic, so need to utilize this two big active component in the preparation as far as possible, and this dosage form of soft capsule has satisfied such needs, and the bioavailability height absorbs fast simultaneously.
Summary of the invention
The object of the present invention is to provide a kind of bupleurum root soft capsule and production method thereof, the product oral form of administration, its steady quality, easy to use effective.
Bupleurum root soft capsule provided by the present invention is made up of medicinal liquid and softgel shell two parts.Its herb liquid contains active ingredient Radix Bupleuri volatile oil, Radix Bupleuri extract, also contains stabilizing agent, and active ingredient is dissolved in the solvent; Softgel shell mainly is made up of gelatin and glycerol, and the weight proportion of gelatin and glycerol is 10: 3.15～10: 3.35 parts, in addition, also contains an amount of antiseptic.
Solvent of the present invention can be one or more in liquid polyethylene glycol, isopropyl alcohol, tween 80, glycerol, propylene glycol, water and the vegetable oil (as Oleum Glycines, Oleum Arachidis hypogaeae semen, Oleum Camelliae etc.).
Antiseptic can be one or more in glycerol, propylene glycol, methyl parahydroxybenzoate, ethylparaben, propyl p-hydroxybenzoate, butyl p-hydroxybenzoate, benzyl p-hydroxybenzoate, P-hydroxybenzoic acid phenyl ester, benzoic acid, the benzyl alcohol.
Stabilizing agent can be one or more in water, glycerol, tween 80, ethyoxyl castor oil hydrogenated, soybean lecithin, Cera Flava, aluminum monostearate, ethyl cellulose, the solid polyethylene glycol.
Among the present invention, the weight proportion of bupleurum root soft capsule herb liquid component is:
The component consumption
Radix Bupleuri extract 100
The Radix Bupleuri volatile oil corresponding amount extracted amount of volatile oil in the Radix Bupleuri of said extracted thing amount (promptly corresponding to)
Solvent 1.6～10
Stabilizing agent 0.3～1.2
Active ingredient in every capsules is fixed, and generally the content of its Radix Bupleuri extract is the 5-15g/ grain, and Radix Bupleuri volatile oil is a corresponding amount.
Gelatin, glycerol proportioning are difficult to grasp in the prescription of softgel shell.The amount of glycerol is too many, and softgel shell is softer, than being easier to extrusion; The amount of glycerol very little, softgel shell is harder, crisp, influences the quality stability and the disintegration time of soft capsule.Gelatin, glycerol proportioning to softgel shell have been carried out detailed experimental study, have obtained a proportioning preferably at last.
An amount of gelatin is added in the rustless steel glue pot, add suitable quantity of water again, airtight, 70 degree insulation 3hr, add glycerol, the antiseptic of test consumption more respectively, stir vacuumize degassing 2hr, put into gelatin heat-preserving container 70 degree insulation standing over night, second day moulding ball, drying at room temperature keeps sample and investigates 3 months, examination softgel shell outward appearance and physical property, found that gelatin and glycerol proportioning be 10: 3.15～3.35 o'clock the most suitable.The softgel shell prescription that is filtered out is applicable to the environment of warm moist.
The preparation technology of bupleurum root soft capsule may further comprise the steps:
Extract the volatile oil in the Radix Bupleuri earlier, can adopt steam distillation or carbon dioxide supercritical extraction method, preferred supercritical extraction.Collect and extract volatile oil and the medicinal residues that obtain, standby.The reuse conventional method is extracted Radix Bupleuri extract from medicinal residues.Specifically can add 95% ethanol to medicinal residues and decoct secondary, 2 hours for the first time, 1 hour for the second time, the filtrate gradation was filtered, and filtrate merging is evaporated to the thick paste shape, and drying can obtain Radix Bupleuri extract.
After Radix Bupleuri extract beaten powder and cross the 80-120 mesh sieve, feed intake by the prescription proportioning, earlier with the stabilizing agent thermosol in partial solvent, the thermosol thing is joined lentamente in the residual solvent that is preheated to 35～45 degree, the limit edged stirs, and adds solid and Radix Bupleuri volatile oil then again, it is moistening fully fully to mix assurance, cross colloid mill and pulverize the back pelleting, drying, promptly.
The invention provides a kind of bupleurum root soft capsule preparation and preparation technology thereof, product is an oral administered dosage form, can overcome the shortcoming of existing dosage form, and the bioavailability height satisfies the standard of such dosage form aspect outward appearance, hardness, disintegration etc. and physical and chemical stability.
The specific embodiment
The invention is further illustrated by the following examples.
Embodiment 1:
Component amount (gram/grain)
Radix Bupleuri extract is equivalent to crude drug 10g
The Radix Bupleuri volatile oil corresponding amount
PEG400 0.40g
Cera Flava 0.02
Glycerol 0.01
Water is an amount of
Capsule shells 0.22
Embodiment 2:
Component amount (gram/grain)
Radix Bupleuri extract is equivalent to crude drug 5g
The Radix Bupleuri volatile oil corresponding amount
Oleum Arachidis hypogaeae semen 0.26
Tween 80 0.01
Ethyl cellulose 0.02
Water is an amount of
Capsule shells 0.19
Embodiment 3:
Component amount (gram/grain)
Radix Bupleuri extract is equivalent to crude drug 15g
The Radix Bupleuri volatile oil corresponding amount
Isopropyl alcohol 0.40
Propylene glycol 0.10
Soybean lecithin 0.05
Capsule shells 0.25
The preparation technology of embodiment is as follows:
Take by weighing the Radix Bupleuri of recipe quantity, extract volatile oil wherein, can adopt steam distillation or carbon dioxide supercritical extraction method, the preferred supercritical extraction of method.Volatile oil that collection obtains and medicinal residues.Medicinal residues obtain Radix Bupleuri extract through following processing: medicinal residues add 95% ethanol and decoct secondary, and 2 hours for the first time, 1 hour for the second time, the filtrate gradation was filtered, and filtrate merging is evaporated to the thick paste shape, and drying can obtain Radix Bupleuri extract.
After Radix Bupleuri extract beaten powder and cross 100 mesh sieves, feed intake by the prescription proportioning, earlier with the stabilizing agent thermosol in partial solvent, the thermosol thing is joined lentamente in the residual solvent that is preheated to 45 degree, the limit edged stirs, and adds solid and Radix Bupleuri volatile oil then again, it is moistening fully fully to mix assurance, cross colloid mill and pulverize the back pelleting, drying, promptly.
Claims (6)
1, a kind of bupleurum root soft capsule is made up of medicinal liquid and softgel shell two parts, it is characterized in that medicinal liquid contains active ingredient Radix Bupleuri volatile oil, Radix Bupleuri extract, and contains stabilizing agent, and active ingredient is dissolved in the solvent; Softgel shell mainly is made up of gelatin and glycerol, also contains an amount of antiseptic, and the weight proportion of gelatin and glycerol is 10: 3.15～10: 3.35.
2, bupleurum root soft capsule according to claim 1 is characterized in that solvent is one or more in liquid polyethylene glycol, isopropyl alcohol, tween 80, glycerol, propylene glycol, water and the vegetable oil.
3, bupleurum root soft capsule according to claim 1 is characterized in that antiseptic is one or more in glycerol, propylene glycol, methyl parahydroxybenzoate, ethylparaben, propyl p-hydroxybenzoate, butyl p-hydroxybenzoate, benzyl p-hydroxybenzoate, P-hydroxybenzoic acid phenyl ester, benzoic acid, the benzyl alcohol.
4, bupleurum root soft capsule according to claim 1 is characterized in that the weight proportion of medicinal liquid component is:
The component consumption
Radix Bupleuri extract 100
The Radix Bupleuri volatile oil corresponding amount
Solvent 1.6～10
Stabilizing agent 0.3～1.2
5, a kind of preparation method as the described bupleurum root soft capsule of claim 1-4 is characterized in that may further comprise the steps:
After Radix Bupleuri extract beaten powder and cross the 80-120 mesh sieve, feed intake by the prescription proportioning, earlier with the stabilizing agent thermosol in partial solvent, the thermosol thing is joined lentamente in the residual solvent that is preheated to 35～45 degree, the limit edged stirs, and adds Radix Bupleuri extract and Radix Bupleuri volatile oil then again, it is moistening fully fully to mix assurance, cross colloid mill and pulverize the back pelleting, drying, promptly.
6,, it is characterized in that adopting steam distillation or carbon dioxide supercritical extraction method to extract Radix Bupleuri volatile oil according to bupleurum root soft capsule preparation method as claimed in claim 5; The reuse conventional method extracts Radix Bupleuri extract from the Radix Bupleuri medicinal residues.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 03116422 CN1259038C (en) | 2003-04-16 | 2003-04-16 | Radix bupleuri soft capsule pharmaceutics and preparation process thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 03116422 CN1259038C (en) | 2003-04-16 | 2003-04-16 | Radix bupleuri soft capsule pharmaceutics and preparation process thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1449794A true CN1449794A (en) | 2003-10-22 |
| CN1259038C CN1259038C (en) | 2006-06-14 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 03116422 Expired - Fee Related CN1259038C (en) | 2003-04-16 | 2003-04-16 | Radix bupleuri soft capsule pharmaceutics and preparation process thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1259038C (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100400053C (en) * | 2005-05-17 | 2008-07-09 | 重庆医药工业研究院有限责任公司 | Bupleurum root soft capsule and its preparation method |
-
2003
- 2003-04-16 CN CN 03116422 patent/CN1259038C/en not_active Expired - Fee Related
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100400053C (en) * | 2005-05-17 | 2008-07-09 | 重庆医药工业研究院有限责任公司 | Bupleurum root soft capsule and its preparation method |
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| Publication number | Publication date |
|---|---|
| CN1259038C (en) | 2006-06-14 |
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| EE01 | Entry into force of recordation of patent licensing contract |
Assignee: Yanzhou Hill Kangtai Pharmaceutical Co., Ltd. Assignor: Botai Medicine Science and Technology Co., Ltd., Shanghai Contract fulfillment period: 2008.12.29 to 2023.4.15 contract change Contract record no.: 2009370000078 Denomination of invention: Radix bupleuri soft capsule pharmaceutics and preparation process thereof Granted publication date: 20060614 License type: Exclusive license Record date: 2009.4.24 |
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Free format text: EXCLUSIVE LICENSE; TIME LIMIT OF IMPLEMENTING CONTACT: 2008.12.29 TO 2023.4.15; CHANGE OF CONTRACT Name of requester: YANZHOU HILL KANGTAI PHARMACEUTICAL CO., LTD. Effective date: 20090424 |
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Owner name: YANZHOU HILL KANGTAI PHARMACEUTICAL CO., LTD. Free format text: FORMER OWNER: SHANGHAI BOTAI PHARMACEUTICAL TECHNOLOGY CO., LTD. Effective date: 20091023 |
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Effective date of registration: 20091023 Address after: Xin Yan Zhen private industrial park in Shandong city of Yanzhou Province Patentee after: Yanzhou Hill Kangtai Pharmaceutical Co., Ltd. Address before: Room 335, No. 3021, National Road, Shanghai, China Patentee before: Botai Medicine Science and Technology Co., Ltd., Shanghai |
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| C56 | Change in the name or address of the patentee |
Owner name: SHANDONG XI ER KANGTAI PHARMACEUTICAL CO., LTD. Free format text: FORMER NAME: YANZHOU XI ER KANGTAI PHARMACEUTICAL CO., LTD. |
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| CP01 | Change in the name or title of a patent holder |
Address after: Xin Yan Zhen Private Industrial Park 272100 Shandong city of Yanzhou Province Patentee after: SHANDONG XIER KANGTAI PHARMACEUTICAL CO., LTD. Address before: Xin Yan Zhen Private Industrial Park 272100 Shandong city of Yanzhou Province Patentee before: Yanzhou Hill Kangtai Pharmaceutical Co., Ltd. |
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