CN1329094A - Extraction and separation method of notoginseng polysaccharide - Google Patents
Extraction and separation method of notoginseng polysaccharide Download PDFInfo
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- CN1329094A CN1329094A CN 01108493 CN01108493A CN1329094A CN 1329094 A CN1329094 A CN 1329094A CN 01108493 CN01108493 CN 01108493 CN 01108493 A CN01108493 A CN 01108493A CN 1329094 A CN1329094 A CN 1329094A
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- precipitate
- polysaccharide
- ethanol
- notoginseng polysaccharide
- notoginseng
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- 241000180649 Panax notoginseng Species 0.000 title claims abstract description 73
- 235000003143 Panax notoginseng Nutrition 0.000 title claims abstract description 73
- 150000004676 glycans Chemical class 0.000 title claims abstract description 63
- 229920001282 polysaccharide Polymers 0.000 title claims abstract description 63
- 239000005017 polysaccharide Substances 0.000 title claims abstract description 63
- 238000000605 extraction Methods 0.000 title claims description 14
- 238000000926 separation method Methods 0.000 title claims description 12
- 238000000034 method Methods 0.000 claims abstract description 19
- 239000003814 drug Substances 0.000 claims abstract description 14
- 238000002360 preparation method Methods 0.000 claims abstract description 14
- 230000002708 enhancing effect Effects 0.000 claims abstract description 6
- 239000002246 antineoplastic agent Substances 0.000 claims abstract description 5
- 229940041181 antineoplastic drug Drugs 0.000 claims abstract description 5
- 229940079593 drug Drugs 0.000 claims abstract 3
- 230000005965 immune activity Effects 0.000 claims abstract 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 55
- 238000001556 precipitation Methods 0.000 claims description 24
- 238000009835 boiling Methods 0.000 claims description 22
- 239000002244 precipitate Substances 0.000 claims description 18
- 239000007788 liquid Substances 0.000 claims description 16
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 16
- 239000000843 powder Substances 0.000 claims description 12
- 238000010992 reflux Methods 0.000 claims description 6
- 239000000284 extract Substances 0.000 claims description 5
- 238000001914 filtration Methods 0.000 claims description 3
- 229930182490 saponin Natural products 0.000 claims description 3
- 239000000469 ethanolic extract Substances 0.000 claims description 2
- 208000006454 hepatitis Diseases 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims description 2
- 150000007949 saponins Chemical class 0.000 claims description 2
- 238000001816 cooling Methods 0.000 claims 4
- 238000005119 centrifugation Methods 0.000 claims 2
- 239000006228 supernatant Substances 0.000 claims 2
- 235000017709 saponins Nutrition 0.000 claims 1
- 239000002994 raw material Substances 0.000 abstract description 6
- 238000004519 manufacturing process Methods 0.000 abstract description 5
- 239000012535 impurity Substances 0.000 abstract description 3
- 239000002904 solvent Substances 0.000 abstract description 2
- 238000011031 large-scale manufacturing process Methods 0.000 abstract 1
- 244000131316 Panax pseudoginseng Species 0.000 description 13
- 235000003181 Panax pseudoginseng Nutrition 0.000 description 13
- 238000001035 drying Methods 0.000 description 10
- 238000003809 water extraction Methods 0.000 description 10
- 241001465754 Metazoa Species 0.000 description 6
- 239000000463 material Substances 0.000 description 5
- 238000004062 sedimentation Methods 0.000 description 5
- 206010028980 Neoplasm Diseases 0.000 description 4
- 238000002474 experimental method Methods 0.000 description 4
- 230000012010 growth Effects 0.000 description 4
- 230000036039 immunity Effects 0.000 description 4
- 238000005507 spraying Methods 0.000 description 4
- 239000010409 thin film Substances 0.000 description 4
- 241000196324 Embryophyta Species 0.000 description 3
- 239000012141 concentrate Substances 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 231100000753 hepatic injury Toxicity 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- 241000208340 Araliaceae Species 0.000 description 2
- 206010019695 Hepatic neoplasm Diseases 0.000 description 2
- 238000012449 Kunming mouse Methods 0.000 description 2
- 206010067125 Liver injury Diseases 0.000 description 2
- 235000002791 Panax Nutrition 0.000 description 2
- 241000208343 Panax Species 0.000 description 2
- -1 aliphatics alkynes Chemical class 0.000 description 2
- 201000011510 cancer Diseases 0.000 description 2
- 235000008504 concentrate Nutrition 0.000 description 2
- 230000002401 inhibitory effect Effects 0.000 description 2
- 235000014666 liquid concentrate Nutrition 0.000 description 2
- 239000001397 quillaja saponaria molina bark Substances 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 230000001629 suppression Effects 0.000 description 2
- VZGDMQKNWNREIO-UHFFFAOYSA-N tetrachloromethane Chemical compound ClC(Cl)(Cl)Cl VZGDMQKNWNREIO-UHFFFAOYSA-N 0.000 description 2
- 208000026487 Triploidy Diseases 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 230000003187 abdominal effect Effects 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- OORMXZNMRWBSTK-LGFJJATJSA-N dammarane Chemical compound C1CCC(C)(C)[C@@H]2CC[C@@]3(C)[C@]4(C)CC[C@H]([C@H](C)CCCC(C)C)[C@H]4CC[C@@H]3[C@]21C OORMXZNMRWBSTK-LGFJJATJSA-N 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 229930003944 flavone Natural products 0.000 description 1
- 150000002213 flavones Chemical class 0.000 description 1
- 235000011949 flavones Nutrition 0.000 description 1
- 229930182470 glycoside Natural products 0.000 description 1
- 150000002338 glycosides Chemical class 0.000 description 1
- 230000023597 hemostasis Effects 0.000 description 1
- 231100000283 hepatitis Toxicity 0.000 description 1
- 238000009776 industrial production Methods 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 238000012827 research and development Methods 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 238000001694 spray drying Methods 0.000 description 1
- 231100000820 toxicity test Toxicity 0.000 description 1
- 238000009602 toxicology test Methods 0.000 description 1
- 230000004614 tumor growth Effects 0.000 description 1
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- Medicines Containing Plant Substances (AREA)
Abstract
提供一种三七多糖的提取分离方法,该方法以中药三七为原料生产三七多糖,增加了三七原料的综合利用,降低多糖的杂质,减少了溶剂用量,降低了成本,同时提高了生产效率,适合于大规模生产。同时,提供了用上述方法得到的三七多糖在制备抗肿瘤药物中的应用;三七多糖在制备增强免疫活性药物中的应用以及三七多糖在制备抗肝炎药物中的应用。A method for extracting and separating Panax notoginseng polysaccharide is provided. The method uses the traditional Chinese medicine Panax notoginseng as a raw material to produce Panax notoginseng polysaccharide, which increases the comprehensive utilization of Panax notoginseng raw materials, reduces the impurities of the polysaccharide, reduces the amount of solvent used, and reduces the cost. The production efficiency is improved, and it is suitable for large-scale production. At the same time, it provides the application of the notoginseng polysaccharide obtained by the above method in the preparation of antitumor drugs; the application of the notoginseng polysaccharide in the preparation of drugs for enhancing immune activity;
Description
The invention belongs to the pharmaceutical chemistry field, specifically, belong to the extraction and separation method of medicinal plant Radix Notoginseng polysaccharide.
Pseudo-ginseng (Panax notoginseng (Burk.) F.H.Chen), have another name called pseudo-ginseng, be Araliaceae (Araliaceae) Panax (Panax Linn.) plant, mainly cultivate in Yunnan mountain of papers and Baise of Guangxi area, it is the famous valuable ingredient of traditional Chinese medicine of China, have hemostasis, loose effects such as silt, detumescence, pain relieving in recent years, the research and development of pseudo-ginseng come into one's own day by day.The pseudo-ginseng complex chemical composition was just studied from the thirties, but after the seventies along with the separation of plant glycoside and the development of chemical structure authenticate technology, significant progress has just been arranged.Result of study shows, contains saponin, flavones, amino acid, polysaccharide, lipid acid, aliphatics alkynes class and peptides etc. in the pseudo-ginseng, is all having important exploitation to be worth aspect pharmaceuticals and the natural health-care products.Wherein, dammarane type four-ring triterpenoid class saponin is considered to one of major physiological activeconstituents of pseudo-ginseng.So research in the past mainly concentrates on the arasaponin aspect, the polysaccharide component of pseudo-ginseng to be studied seldom, the extraction and separation method of Radix Notoginseng polysaccharide of the present invention is not seen in the prior art report.
The object of the present invention is to provide a kind of extraction and separation method of Radix Notoginseng polysaccharide, this method is the raw material production Radix Notoginseng polysaccharide with the Chinese medicine pseudo-ginseng, increased the comprehensive utilization of pseudo-ginseng raw material, reduce the impurity of polysaccharide, reduced solvent load, reduce cost, improved production efficiency simultaneously, be suitable for scale operation.Simultaneously, the present invention also provides the application of Radix Notoginseng polysaccharide in the preparation antitumor drug that aforesaid method obtains; Application and Radix Notoginseng polysaccharide the application in preparation Antihepatitis medicament of Radix Notoginseng polysaccharide in preparation enhancing immunity active medicine.
In order to realize above-mentioned purpose of the present invention, the invention provides following technical scheme:
The extraction and separation method of Radix Notoginseng polysaccharide is got Radix Notoginseng, uses boiling water extraction after crushed, and extracting solution is centrifugal or filter, and adds the long-pending ethanol sedimentation of diploid after clear liquid concentrates, collects centrifugal or filter after precipitation, get Radix Notoginseng polysaccharide after the drying.
In the aforesaid method, Radix Notoginseng is pulverized the back with boiling water extraction three times, and cooled and filtered is removed precipitation, and the clear liquid thin film concentration adds the long-pending ethanol of diploid and mixes to small volume, leaves standstill after one hour 9000rpm centrifugal 10 minutes, and collecting precipitation precipitate the dry Radix Notoginseng polysaccharide that gets.
In the aforesaid method, Radix Notoginseng is pulverized back boiling water extraction three times, cooled and filtered is removed precipitation, the clear liquid spraying drying gets dry powder, and dry powder is dissolved in boiling water, the centrifugal precipitation of going, clear liquid adds the long-pending ethanol of diploid and mixes, left standstill after one hour 9000rpm centrifugal 10 minutes, collecting precipitation, dry Radix Notoginseng polysaccharide.
The another kind of extraction and separation method of Radix Notoginseng polysaccharide is provided simultaneously, get Radix Notoginseng, use extraction using alcohol after crushed, ethanol extract is used to prepare arasaponin, residue is used boiling water extraction again, and the centrifugal or filtration of water extract adds the long-pending ethanol sedimentation of diploid after clear liquid concentrates, collect centrifugal or filter after precipitation, after the drying Radix Notoginseng polysaccharide.
In the aforesaid method, Radix Notoginseng is pulverized the back with 70% alcohol reflux, use boiling water extraction three times after the residue drying, cooled and filtered is removed precipitation, the clear liquid thin film concentration is to small volume, adds the long-pending ethanol of diploid and mixes, and leaves standstill after one hour 9000rpm centrifugal 10 minutes, collecting precipitation precipitates the dry Radix Notoginseng polysaccharide that gets.
In the aforesaid method, Radix Notoginseng is pulverized the back with 70% alcohol reflux, use boiling water extraction three times after the residue drying, cooled and filtered is removed precipitation, and the clear liquid spraying drying gets dry powder, get dry powder and be dissolved in boiling water, the centrifugal precipitation of going, clear liquid adds the long-pending ethanol of diploid and mixes, and leaves standstill after one hour 9000rpm centrifugal 10 minutes, collecting precipitation, the dry Radix Notoginseng polysaccharide that gets.
Simultaneously, the present invention also provides the application of the Radix Notoginseng polysaccharide that obtains with aforesaid method in the preparation antitumor drug; Application and Radix Notoginseng polysaccharide the application in preparation Antihepatitis medicament of Radix Notoginseng polysaccharide in preparation enhancing immunity active medicine.
In order to embody the compared with prior art existing superiority of the present invention, the pharmacology test result of the product that will go out with principle of the present invention and extraction separation of the present invention illustrates its superiority and purposes below:
1, principle of the present invention: the proposition of technical solution of the present invention is that the principle that can not be dissolved in alcohol according to the polysaccharide water soluble utilizes the method for ethanol sedimentation to extract Radix Notoginseng polysaccharide.
2, the pharmacology test result of Radix Notoginseng polysaccharide:
The Radix Notoginseng polysaccharide that obtains with extraction and separation method of the present invention carries out pharmacology test, and preliminary study result shows that Radix Notoginseng polysaccharide is to CCl
4Due to the kunming mice liver injury have significant protective effect, to animal transplanting tumor S
180The solid-type growth has the obvious suppression effect, to animal transplanting tumor liver cancer (H
22) solid-type growth has the obvious suppression effect, it is active and suppress the activity of hepatitis virus also to have significant enhancing immunity, and its toxicology test has also proved its security, has good application prospects.
2-1. Radix Notoginseng polysaccharide is to the provide protection of carbon tetrachloride hepatic injury
The result shows through preliminary experiment: give the animal abdominal injection, Radix Notoginseng polysaccharide dosage is respectively 75mg/kg and 150mg/kg, once a day, logotype three days, (0.1%, 10mg/kg) the kunming mice liver injury due to has the certain protection effect to tetracol phenixin.Gpt (ALT) is an evaluation index in the serum to measure.Model group ALT136.7 ± 15.6u; Polysaccharide dosage size is followed successively by 58.0 ± 22.3u and 80.2 ± 19.7u respectively, with model group (CCl
4) compare, difference has significance (p＜0.05).
2-2. Radix Notoginseng polysaccharide is to the influence of animal transplanting tumor growth
(1) to animal transplanting tumor S
180The influence of solid-type growth
The result shows through preliminary experiment: Radix Notoginseng polysaccharide is 100mg/kg and 200mg/kg at dosage, once a day, logotype 8 days, the heavy inhibiting rate of knurl is followed successively by 23.8% and 37.3% respectively, and heavy dose of group is compared with control group has notable difference (p＜0.05).
(2) to animal transplanting tumor liver cancer (H
22) influence of solid-type growth
The result shows through preliminary experiment: Radix Notoginseng polysaccharide is 100mg/kg and 200mg/kg at dosage, once a day, logotype 8 days, the heavy inhibiting rate of knurl is followed successively by 34.6% and 46.5% respectively, compares with control group all to have notable difference (p＜0.05).
To sum up, compared with prior art, superiority of the present invention is:
1, prior art mainly concentrates on arasaponin research and extracts, the polysaccharide component of pseudo-ginseng is studied seldom, and be that the raw material production Radix Notoginseng polysaccharide does not appear in the newspapers with the Chinese medicine pseudo-ginseng;
2, the present invention at first uses 70% extraction using alcohol arasaponin, carries out the extraction of polysaccharide again, can strengthen the comprehensive utilization to the pseudo-ginseng raw material, increases the benefit, and can reduce the impurity of polysaccharide simultaneously;
3, prior art utilizes triploid to amass the ethanol sedimentation polysaccharide, and the present invention utilizes diploid to amass the ethanol sedimentation polysaccharide, also can achieve the goal, and can reduce the ethanol consumption, reduces cost;
4, the present invention utilizes spray drying process to concentrate the pseudo-ginseng water extract, has improved production efficiency, is suitable for large-scale industrial production;
5, do not see in the prior art that the application of Radix Notoginseng polysaccharide in the preparation antitumor drug arranged, the application of Radix Notoginseng polysaccharide in preparation enhancing immunity active medicine and the report of the application of Radix Notoginseng polysaccharide in the preparation Antihepatitis medicament.
Further specify essentiality content of the present invention with the embodiment of the invention below, but content of the present invention is not limited thereto.
Embodiment 1:
Material: Radix Notoginseng is dry medicinal material, originates from the Yunnan mountain of papers; Ethanol is that chemical reagent one factory in Tianjin produces, and whizzer is the Beckman product.
Experimental technique:
Get Radix Notoginseng 3kg, pulverize the back with boiling water extraction three times, cooled and filtered is removed precipitation, and the clear liquid thin film concentration adds the long-pending ethanol of diploid and mixes to small volume, leaves standstill after one hour 9000rpm centrifugal 10 minutes, and collecting precipitation precipitate the dry Radix Notoginseng polysaccharide 41g of getting.
Embodiment 2:
Material is selected with embodiment 1.Get Radix Notoginseng 3kg and pulverize back boiling water extraction three times, cooled and filtered is removed precipitation, the clear liquid spraying drying gets the about 100g of dry powder, dry powder is dissolved in boiling water, cross elimination precipitation, clear liquid adds the long-pending ethanol of diploid and mixes, and leaves standstill after one hour 9000rpm centrifugal 10 minutes, collecting precipitation, the dry Radix Notoginseng polysaccharide 33g that gets.
Embodiment 3:
Material is selected with embodiment 1.Get Radix Notoginseng 3kg, pulverize the back with 70% alcohol reflux, use boiling water extraction three times after the residue drying, cooled and filtered is removed precipitation, the clear liquid thin film concentration is to small volume, adds the long-pending ethanol of diploid and mixes, and leaves standstill after one hour 9000rpm centrifugal 10 minutes, collecting precipitation precipitates the dry Radix Notoginseng polysaccharide 35g of getting.
Embodiment 4:
Material is selected with embodiment 1.Get Radix Notoginseng 100kg, pulverize the back with 70% alcohol reflux, use boiling water extraction three times after the residue drying, cooled and filtered is removed precipitation, and the clear liquid spraying drying gets the about 3.5kg of dry powder, get dry powder 1kg and be dissolved in boiling water, centrifugal (or filter) goes precipitation, and the stillness of night adds the long-pending ethanol of diploid and mixes, and leaves standstill after one hour 9000rpm centrifugal 10 minutes, collecting precipitation, the dry Radix Notoginseng polysaccharide 390g that gets.
Claims (9)
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| Application Number | Priority Date | Filing Date | Title |
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| CN 01108493 CN1329094A (en) | 2001-05-31 | 2001-05-31 | Extraction and separation method of notoginseng polysaccharide |
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| CN 01108493 CN1329094A (en) | 2001-05-31 | 2001-05-31 | Extraction and separation method of notoginseng polysaccharide |
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Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102585029A (en) * | 2012-03-08 | 2012-07-18 | 玉溪市维和生物技术有限责任公司 | Preparation method and application of physiologically active notoginseng polysaccharide |
| CN102961424A (en) * | 2012-11-23 | 2013-03-13 | 云南云科药业有限公司 | Panax notoginseng polysaccharide extract and preparation method, preparations and applications thereof |
| CN103087211A (en) * | 2013-01-16 | 2013-05-08 | 中国科学院昆明植物研究所 | Method for reducing ash content of notoginseng polysaccharide |
| CN103589811A (en) * | 2012-08-15 | 2014-02-19 | 天津天士力现代中药资源有限公司 | Separation and purification method for monosaccharides and disaccharides in compound red sage root extract |
| CN104710538A (en) * | 2013-12-16 | 2015-06-17 | 中国科学院上海药物研究所 | Arabinogalactan of flowers of panax notoginseng (burK.)F.H.Chen, and preparation method and use thereof |
| CN106119429A (en) * | 2016-06-27 | 2016-11-16 | 云南省农业科学院甘蔗研究所 | A kind of production method of Radix Notoginseng sugar |
| CN106361602A (en) * | 2016-08-24 | 2017-02-01 | 登封市科创商务咨询有限公司 | Panax notoginseng polysaccharide balancing and moisturizing lotion |
| CN106565849A (en) * | 2016-10-20 | 2017-04-19 | 河南中医药大学 | A method of preparing sedum aizoon L. polysaccharides and applications of the polysaccharides |
| CN106832037A (en) * | 2017-03-30 | 2017-06-13 | 云南润嘉药业有限公司 | A kind of notoginseng polysaccharide extracting method rapidly and efficiently |
| CN109354629A (en) * | 2018-09-07 | 2019-02-19 | 云南多糖生物科技有限公司 | It is a kind of neutrality notoginseng polysaccharide method for extraction and purification and application |
| CN109467612A (en) * | 2018-11-01 | 2019-03-15 | 山东汇润膳食堂股份有限公司 | A kind of method for separating and extracting Panax notoginseng with alcohol grinding |
| CN116375903A (en) * | 2023-04-23 | 2023-07-04 | 南京林业大学 | Preparation method of natural notoginseng polysaccharide and Pickering emulsion preparation method |
-
2001
- 2001-05-31 CN CN 01108493 patent/CN1329094A/en active Pending
Cited By (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102585029A (en) * | 2012-03-08 | 2012-07-18 | 玉溪市维和生物技术有限责任公司 | Preparation method and application of physiologically active notoginseng polysaccharide |
| CN103589811A (en) * | 2012-08-15 | 2014-02-19 | 天津天士力现代中药资源有限公司 | Separation and purification method for monosaccharides and disaccharides in compound red sage root extract |
| CN102961424A (en) * | 2012-11-23 | 2013-03-13 | 云南云科药业有限公司 | Panax notoginseng polysaccharide extract and preparation method, preparations and applications thereof |
| CN103087211A (en) * | 2013-01-16 | 2013-05-08 | 中国科学院昆明植物研究所 | Method for reducing ash content of notoginseng polysaccharide |
| CN104710538B (en) * | 2013-12-16 | 2017-10-31 | 中国科学院上海药物研究所 | A kind of sanchi flower arabogalactan and its production and use |
| CN104710538A (en) * | 2013-12-16 | 2015-06-17 | 中国科学院上海药物研究所 | Arabinogalactan of flowers of panax notoginseng (burK.)F.H.Chen, and preparation method and use thereof |
| WO2015090180A1 (en) * | 2013-12-16 | 2015-06-25 | 中国科学院上海药物研究所 | Sanchi flower arab galactan and preparation method and use thereof |
| CN106119429A (en) * | 2016-06-27 | 2016-11-16 | 云南省农业科学院甘蔗研究所 | A kind of production method of Radix Notoginseng sugar |
| CN106361602A (en) * | 2016-08-24 | 2017-02-01 | 登封市科创商务咨询有限公司 | Panax notoginseng polysaccharide balancing and moisturizing lotion |
| CN106565849A (en) * | 2016-10-20 | 2017-04-19 | 河南中医药大学 | A method of preparing sedum aizoon L. polysaccharides and applications of the polysaccharides |
| CN106565849B (en) * | 2016-10-20 | 2018-10-09 | 河南中医药大学 | A kind of preparation method and applications of aizoon stonecrop polysaccharide |
| CN106832037A (en) * | 2017-03-30 | 2017-06-13 | 云南润嘉药业有限公司 | A kind of notoginseng polysaccharide extracting method rapidly and efficiently |
| CN109354629A (en) * | 2018-09-07 | 2019-02-19 | 云南多糖生物科技有限公司 | It is a kind of neutrality notoginseng polysaccharide method for extraction and purification and application |
| CN109467612A (en) * | 2018-11-01 | 2019-03-15 | 山东汇润膳食堂股份有限公司 | A kind of method for separating and extracting Panax notoginseng with alcohol grinding |
| CN116375903A (en) * | 2023-04-23 | 2023-07-04 | 南京林业大学 | Preparation method of natural notoginseng polysaccharide and Pickering emulsion preparation method |
| CN116375903B (en) * | 2023-04-23 | 2024-01-26 | 南京林业大学 | Preparation method of natural pseudo-ginseng polysaccharide and preparation method of Pickering emulsion |
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