[go: up one dir, main page]

CN1328444A - Preparation of aqueous-based cleaning agents which form vesicles and which contain active agents, method for their production and their utilization - Google Patents

Preparation of aqueous-based cleaning agents which form vesicles and which contain active agents, method for their production and their utilization Download PDF

Info

Publication number
CN1328444A
CN1328444A CN99813757A CN99813757A CN1328444A CN 1328444 A CN1328444 A CN 1328444A CN 99813757 A CN99813757 A CN 99813757A CN 99813757 A CN99813757 A CN 99813757A CN 1328444 A CN1328444 A CN 1328444A
Authority
CN
China
Prior art keywords
sterol
detergent compositions
surfactant
alkyl
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN99813757A
Other languages
Chinese (zh)
Inventor
V·帕斯派勒瓦－库恩
S·施曼迪特
R·D·比特勒
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merz and Co GmbH and Co KG
Original Assignee
Merz and Co GmbH and Co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merz and Co GmbH and Co KG filed Critical Merz and Co GmbH and Co KG
Publication of CN1328444A publication Critical patent/CN1328444A/en
Pending legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
    • C11D1/88—Ampholytes; Electroneutral compounds
    • C11D1/94—Mixtures with anionic, cationic or non-ionic compounds
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D17/00—Detergent materials or soaps characterised by their shape or physical properties
    • C11D17/0008—Detergent materials or soaps characterised by their shape or physical properties aqueous liquid non soap compositions
    • C11D17/0017—Multi-phase liquid compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/14—Liposomes; Vesicles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/10—Washing or bathing preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00—Preparations for care of the hair
    • A61Q5/02—Preparations for cleaning the hair
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D17/00—Detergent materials or soaps characterised by their shape or physical properties
    • C11D17/0008—Detergent materials or soaps characterised by their shape or physical properties aqueous liquid non soap compositions
    • C11D17/0026—Structured liquid compositions, e.g. liquid crystalline phases or network containing non-Newtonian phase
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/0005—Other compounding ingredients characterised by their effect
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16—Organic compounds
    • C11D3/20—Organic compounds containing oxygen
    • C11D3/2003—Alcohols; Phenols
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16—Organic compounds
    • C11D3/20—Organic compounds containing oxygen
    • C11D3/2068—Ethers
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16—Organic compounds
    • C11D3/36—Organic compounds containing phosphorus
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16—Organic compounds
    • C11D3/38—Products with no well-defined composition, e.g. natural products
    • C11D3/382—Vegetable products, e.g. soya meal, wood flour, sawdust
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/40—Dyes ; Pigments

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Emergency Medicine (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Cosmetics (AREA)
  • Detergent Compositions (AREA)

Abstract

本发明涉及水基洗涤制剂,特别是沐浴液、泡沫浴组合物或洗发剂,它含有表面活性剂以及通用的助剂和添加剂和一种或多种甾醇。这种水基含表面活性剂的制剂自发形成,特别是在使用时,自发形成脂质体结构。本发明还涉及一种制备这些含表面活性剂的制剂的方法以及这些制剂作为洗涤剂的用途。

This invention relates to water-based detergent formulations, particularly bath liquids, foam bath compositions, or shampoos, containing surfactants, as well as general auxiliaries and additives and one or more sterols. These water-based surfactant-containing formulations spontaneously form, particularly upon use, liposome structures. The invention also relates to a method for preparing these surfactant-containing formulations and their use as detergents.

Description

The preparation of aqueous-based cleaning of agents which form vesicles and which contain active agents and preparation thereof and application
The present invention relates to contain preparation of aqueous-based cleaning, particularly bath foam, bubble bath or the shampoo of surfactant and common agent, additive and one or more sterol components.This preparation with property of water-bearing surfactant, particularly in use, spontaneous formation liposome structure.The invention still further relates to the method for this preparation that contains surfactant of preparation and this preparation purposes as detergent.
So far, known have the cleaning product and oily or the ointment preparation that are used to the property of water-bearing surfactant of taking a shower or having a bath that has more or less strong and significant cleaning function or return grease (Rueckfettung) effect.
The vesicle system is widely used at cosmetics and pharmaceutical field as active ingredient carriers and skin nursing component.This respect, the liposome that contains of known cosmetics is vesicle-containing colloid or emulsion, to contain liposome be the vesicle-containing dispersion and also prepared in the pharmacopedics field.Also introduce liposome base cleaning product.For example in " Mederma Regulativ-WaschlotionPlus ", relate to the emulsion-based cleaning product that contains liposome common on a kind of market.This preparation contains oil/water emulsifier and oils and fats mutually, does not contain the material of detergent active certainly.
Equally also introduced in water for bathing by oil bath preparation or factice body preparation and bathing tablet and formed liposome.DE-OS4205548 has described the bathing and the shower additive of (vesikelbildend) feature that has into vesicle, and it contains fatty oil and/or apolar substance, also contains one or more oil soluble surfactants and one or more become vesicle lipid.Here, the HLB value of oil soluble surfactant is 6-13, and becoming the HLB value of vesicle lipid is 2-6.
DE19602346.7 has introduced the factice body of the shower with vesicle feature, it contains more than 30% one or more lipophilic ingredients, 0.1-20% one-tenth vesicle material and common agent and additive have the emulsifier system of being made up of with 1: 2 to 1: 0.2 ratio one or more water/oil and one or more oil/water emulsifiers in addition.
This detergent that contains lipid, the loss of skin lipid in the time of can being equilibrated at decontamination, its preparation is to be undertaken by be manufactured into the one-tenth vesicle decentralized photo that makes in advance in preparation, or liposome, particularly under the situation as the bath additives use, form by the lipid that contains in the preparation by the water contact in use.
For the said goods, or do not contain surfactant or containing under the situation of surfactant, those particularly relevant systems with oil, they should stop the interaction of liposome structure and surfactant in the aqueous solution, so that it does not dissolve.Also do not exist at present the aqueous that does not contain fatty oil or oily ingredient and formation liposome structure to contain the preparation of surfactant.Always be to use into vesicle lipid in these cleaning products, producing liposome structure so far, for example phospholipid, sheath lipoid or ceramide.
R.A.Wachter etc. are in 75 years the 11/94th of Parf ü merie und Kosmetik (perfume and cosmetics), and the phytosterol of introducing the natural generation of use in the 755-759 page or leaf is as the active substance of plant in the cosmetics.Here, phytosterol can obtain from different oil and oils and fats, and for example Fructus Maydis oil, Oleum Brassicae campestris, Oleum Glycines, Fructus Canarii albi wet goods are made up of cupreol, campesterol and stigmasterol basically.ProductName Generol 122 be meant a kind of by the product mix above-mentioned three plant sterols components that obtain in the Oleum Glycines, that mainly form with cupreol (58.1%) and 29.8% campesterol and 4.5% stigmasterol.The ethoxylated products variant, particularly Generol that except that this this, also have above-mentioned plant sterol 122 variant.Obtain a series of products, for example Generol according to the ethoxyquin degree with different qualities 122 E5 (5Mol EO) mainly are hydrophobic, and those ethoxyquin degree are 10,16 or 25 product.
The product of back has the feature of typical oil/water emulsifier.In view of the above, the latter can and be used as solubilizing agent as the corresponding emulsifying agent of oil/aqueous emulsion, but not ethoxylated products is suitable for doing water/emulsifier or coemulsifier.Plant sterol also actively is used to be compromised or the skin by environmental effect, for example for body constitution neurodermatitis or dermatitis solaris symptom except the emulsifying feature.In addition, these products are done the emulsion except above-mentioned being suitable for, and also are suitable for the hairdo cleanout fluid.The shampoo that contains Generol by use can improve the gloss of wettable comb and hair.Introduce dry skin water/oily skin cream in the above-mentioned document, except that containing general water/emulsifier and different oil ingredients and thickening agent and stabilizing agent, also contained 1%Generol 122 make coemulsifier.In addition, a kind of hair flushing liquor has also been introduced in the there, and it also contains a kind of oil ingredient except containing cation emulsion substrate and thickening agent and additive, a kind of oil/water floating agent and 1.0%Generol 122.In addition, also determine Generol here 122 are fit to and long-chain fatty acid, aliphatic alcohol or phospholipid combination, formation multilamellar shape vesicle or layer.This is because phytosterol inserts in the laminar lipid layer.Ethoxylation Generol product and Generol 122 is to exist with layer structure on the contrary.Water content is lower than at 70% o'clock and produces lamellar phase, but water content brings up to and be higher than at 70% o'clock, and having taken place to multilamelar vesicles is the transition of liposome.Yet, do not allow to exist surfactant here.
But the Clean Living agent contains surfactant, and known its (referring to DE-PS4205548 and WO92/04010) has negative interaction to the stability of liposome because well-known liposome structure by with aqueous solution in surfactant interact and dissolve.To this, so far if do not have special stabilizing measures then can not form to have the liposome component and the general stable water-based system that contains surfactant concerning cleaning product.
Introduced among the US-A5688752 to wash and used and the nursing compositions, they are except containing surfactant, also contain by three component A, the lipid composite that B and C form with completely specified mol ratio, wherein A can be that ceramide, phospholipid, false vitalility are through amide, glycolipid or macrogol ester, B component is the hydro carbons of band polar end group, fatty acid for example, and component C is the helper component that is used for the stable final bilayer that constitutes.Component C for example has 3-β-sterol, or cholesterol, sitosterol, stigmasterol or ergosterol.Should be able to reduce the lipid loss of skin with these products, and therefore reduce dry.
Therefore, theme of the present invention is the aqueous-based cleaning system that preparation contains surfactant, it does not contain oily ingredient, but still has liposome structure when particularly using, and has reached thus to resemble the whole advantages that contain surfactant and contain known washing of lipid product or skin nursing aspect.
This task is achieved by preparation of aqueous-based cleaning according to the present invention, it contain 1-60% one or more particularly be selected from the surfactant of anion and/or nonionic and/or both sexes and/or cationic surfactant, in addition 0-5%, 0.5-2% one or more regulators particularly, 0-5%, 1-3% one or more stabilizing agents particularly, 0-3%, 0.1-1.5% one or more antiseptic particularly, 0-5%, 0.1-2% one or more thickening agents and 0-20% particularly, 0.5-3% active substance particularly, 0-1%, particularly 0.0005-0.01% dyestuff and 0-5%, particularly 0.5-2% one or more turbidity inducing agents or pearling agent, it is characterized in that containing 0.001-15%, particularly 0.01-15%, preferred more especially 0.5-10%, 0.5-5% one or more sterols particularly.
Show that astoundingly the preparation that contains surfactant for these aqueouss of specify forming by the spontaneous liposome structure that forms of one component, and still keeps this structure in preparation or use in washing process.This is visibly different with known oil-containing cleaning compositions, and they are to form liposome when using in water from the above mentioned.Wherein, the loss of the skin lipid that is taken place when the decontamination by surfactant can be remedied by the above-mentioned positive role of sterol.Except having outstanding cleaning function, also prevent the drying of skin thus.Surprisingly can abandon using line of oils to assign to reach this purpose.
Detergent compositions of the present invention preferably contains by anion, nonionic and both sexes, particularly the mixture of being made up of anion and both sexes or anion and non-ionic surface active agent.
It is known that anion surfactant is used for described purpose, be preferably selected from alkyl sulfate (for example C10-C18) and/or corresponding alkyl ether sulfate, particularly in the molecule with 1-6 ethylene oxide groups, sulfosuccinate, sulphosuccinamate, sarcosinate, isethionate, taurate, the ether carboxylic acid, albumen-fatty acid condensation substance, alkylsulfonate and alkylbenzenesulfonate, monoalkyl phosphoric acid esters, monoglyceride sulfate, amide ether sulfate, alkyl sulfoacetate, alpha-alkene sulfonate.Alkyl chain in the above-mentioned surfactant can comprise 8-18 carbon atoms respectively here.
Special preferred alkyl ether sulfate derives from the aliphatic alcohol with 12-18 carbon atoms and 2-6 ethoxyquin degree, lauryl/myristyl ether sulfate for example, Na salt (Texapon for example K14S spezial IS, Elfan NS243S), Zetesol AP (Zetesol LA-2) or single isopropyl alcohol Zetesol AP (Zetesol 2056) or alkyl sulfate, for example sodium lauryl sulfate (Texapon Z), ammonium lauryl sulfate (Texapon ALS) or single isopropyl alcohol ammonium lauryl sulfate (Sulfetal CJOT60).
Suitable in addition particularly succinic acid derivative is as the sulfosuccinate and the sulphosuccinamate of 8-22 carbon atom alkyl of band, for example Wallasol -L29 (lauryl ether-3 disodium sulfosuccinate).
Amphoteric surfactant is selected from the alkyl aminopropionic acid salt with C8-C22 carbon chain length especially, alkyl-, alkyl amido-and sulfobetaines and alkyl glycinate.Preferred especially commodity Dehyton by name The cocamido propyl betaine of K.
Nonionic surfactant is selected from alkanolamide especially, fatty acid ethoxylate, and alcohol ethoxylate, alkyl polyglucoside, particularly with 8-16 carbon atom alkyls, Plantacare for example 2000UP (decyl glucoside), sorbitan esters, for example Tween 20 (polysorbates 20), amine oxide, particularly with the fatty amine oxide of C7-C26 alkyl chain, Incromine Oxide for example C30 (cocamidopropyl propyl amide amine oxide).In addition, suitable have sorbitan esters, an alkyl phenol ethyoxyl thing (C8-C22; 4-20 ethylene oxide group when needing) or the mixing condensation polymer of oxirane and expoxy propane (Pluronics for example Type)
These to the suitable surfactant of detergent also at for example S  FW-Journal, 120 years, 2-3/94, the 115-116 page, 7/94 phase, the 387th page and at Cosmeticsand Toiletries (cosmetics and toilet articles), the 108th volume, 1993, the 83-89 page, and S  FW, 117 years, 1991 the 1st phases, the 3-7 page or the monograph of K.Schrader, Grundlagen und Rezepturen der kosmetika (cosmetic base and preparation), the 2nd edition (1989, H ü thig bibliogony society), description is arranged in the 683-691 page.
Suitable cationic surfactants is the quarternary ammonium salt compound with common 12-22 carbon chain length, for example stearic three ammonium chloride (Steartrimoniumchlorid) or pyridiniujm, for example pyrisepts.
As sterol, specially suitable is plant sterol, for example from Fructus Maydis oil, Oleum Brassicae campestris, Oleum Glycines, Fructus Canarii albi wet goods obtainable those, mainly form by the mixture of Different Weight umber by cupreol, campesterol and stigmasterol, introduce (referring to this application page 4, the 4th section) as R.A.Wachter.In addition, suitable also have cholesterol and derivant thereof, and for example dihydrocholesterol or cholesterol ester are as the acetic acid cholesterol ester.Specially suitable as plant sterol is commodity Generol by name The product of 122N (purified soyasterol).In addition, the sterol and the ethoxylation degree of the above-mentioned type of preferred ethoxylation are 5-30, for example Generol 122N E5D, E10, E16, E25D (ethoxylation soyasterol) or Nikkol DHC-15 and-30 (ethoxylation dihydrocholesterol).
The consumption of above-mentioned sterol is preferably 0.5-5% especially, and particularly 0.5-3%, more preferably 0.5-2%.More especially preferably by non-ethoxylated plant sterol, for example Generol 122N and with the plant sterol of 5 unit ethoxylations, for example Generol The mixture of 122N E5D.The umber of preferred here ethoxylation sterol is greater than or equal to the umber of non-ethoxylated sterol, particularly 5: 1 weight % to 1 in proportion: 1 weight %.Particularly preferred ratio is 3: 1 weight %.In addition, preferably by the consumption of explanation, for example 1 weight % uses non-ethoxylated sterol, for example Generol separately 122N.
The consumption of specially suitable surfactant is 5-30%, particularly 7.5-25%, more especially preferred 10-20%.
In addition, compositions of the present invention also can contain accessory ingredient of in common use and additive.This respect has the cationic polymer as regulator, for example season hydroxyethyl-cellulose-22 (Merquat 280), season protein derivatives, as Soy protein (the Prota Flor of lauryl diammonium (Lauryldimonium) hydroxypropyl hydrolysis The composition of HSQ), silicone derivative, for example Abil B 8863,8843 (dimethicone copolyol), protein hydrolysate or water soluble protein.
Can contain a small amount of (0-5%) one or more stabilizing agents in addition.This respect has for example chelating agent, as Trilon BD (EDTA, sodium salt), the pH regulator agent, citric acid for example, wetting agent, as glycerol, inorganic salt, for example sodium chloride is as viscosity modifier.
In addition equally also have one or more antiseptic and thickening agent (0-5%).Suitable antiseptic for example has iodine propinyl butyl carbamate, phenol ethoxy-ethanol and other anti-corrosion material commonly used, for example right-hydroxybenzoate, formaldehyde and shape disintegrating agent (Formabspalter), sorbic acid and dehydroactic acid and salt thereof, isothiazolone, 5-bromo-5-nitro-1, the 3-dioxane, methyl dibromo glutamic acid nitrile (Methyldibromoglutanonitril) etc.
As thickening agent suitable Volpo for example arranged L3 (lauryl ether-3) or Antil 208 (lauryl ether-3, propylene glycol, acrylate/stearyl ether (Steareth)-50 copolymers), Glucamate DOE120 (PEG-120 methyl glucoside dioleate), Comperlan 100 (coconut oleoyl amine MEA).
Detergent compositions of the present invention can have one or more active substances of specified rate especially.This respect for example has aromatic oil or ether oil, active substance extract and/or vitamin.
This there are especially Oleum menthae, white lemon oil, orange oil, oleum juniperi e baccarae, oil of Rhizoma et radix valerianae, eucalyptus oil, thyme oil, palmorusa oil, oil of rosemary, Oleum lavandula angustifolia, menthol, Rhizoma Zingiberis Recens, Hibiscus syriacus, Calendula, Caulis et folium euphorbiae milii, Lu Yun, Echinacea and Rhizoma Calystegiae Hederaceae extract and pantothenylol, ethoxy salicylate, nicotinate.Here, according to the purpose effect, for example improve hair or skin texture, improve the blood supply ability, lax, aroma-therapeutic or the like can add the suitable combination of active substance.May use other time to be coated with fat (Rueckfetter) equally, as fatty glyceride and ethoxylate thereof, PEG-6 caprylic/capric glyceride (Softigen for example 767) and/or dyestuff, for example patent blue, amide indigo plant, orange RGL, carmine, D C Yellow No. 10.
In preferred embodiments, compositions of the present invention also can contain other component, for example 0.01-5% one or more one-tenth vesicle lipids.This respect is lecithin, phospholipid particularly, for example phosphatidylcholine and ceramide, and ceramide-2 for example ,-3 ,-6, as sheath lipoid, for example Proceramide L, Ceraderm S, Ceraveg
Specially suitable is lecithin (for example soybean lecithin), phosphatidylcholine, Phosphatidylserine or phosphatidyl diethanolamine or their mixture.
The preparation of detergent compositions of the present invention is by finishing one or more sterols roastingization in aqueous tenside solution.Then with the cold stirring of preparation.The words that need can add active substance and other auxiliary agent and additive after this in preparation process.Contrasting suitable temperature is 60 ℃-25 ℃.
The spontaneous formation of product that obtains with compositions of the present invention, particularly in use, spontaneous formation liposome structure.These can observe proof by transmission electron microscope (TEM) after freeze fracture.
May use the product that contains existing liposome to make detergent and nursing agent with detergent compositions of the present invention is feasible.Preparation of the present invention has good dispersibility.They have good washing and foaming properties, comfortable dermal sensation and favourable odor characteristics.They also satisfy the cosmetics requirement.
Compositions of the present invention can be particularly useful as bath foam, bubble bath or shampoo.Planned application target can be with each component various combination.
In addition, product of the present invention also has good stability, can not resemble be generally used for preparing the requirement of liposome article use special and expensive equipment and preparation technology to prepare.The denseness of product can be regulated by a small amount of additive and auxiliary agent according to hope, and this does not change the sensation of skin.By sterol, the property of plant sterol particularly, promptly they can realize other nursing efficacy except the liposome effect as the performance of plant material positive impact hair and skin.
Here show astoundingly that the existence of surfactant does not produce negative effect to the existence or the formation of liposome.In view of the prior art of having described, this is beyond expectation, and is definite in the prior art, and the habitual liposome structure that is produced by for example phospholipid is because of those strong surface-active oil/water emulsifier or surfactant dissolves.
By introducing one or more above-mentioned active substances, can be according to desired purpose preparation indication shower compositions.Can for example use eucalyptus oil, Oleum menthae and the preparation of Echinacea extract to temper bath foam like this; Prepare excited bath foam or prepare bath foam of flaccid muscles with oil of rosemary and white lemon oil with Rhizoma Zingiberis Recens extract, methyl nicotinate, ethoxy salicylate and oleum juniperi e baccarae.
Further illustrate the present invention by the following examples.The transmission electron microscope photo of the product for preparing with the present invention after the embodiment.Here the product that can obviously observe the present invention preparation is at water 1T: 20T, the liposome structure (chondritic) after 37 ℃ of dilutions.I. the preparation of preparation of the present invention.
Being prepared as follows of the product of the following example 1 to 9: by will the explanation sterol 80 ℃ of-90 ℃ of roastingizations in aqueous tenside solution, promptly roastingization is in the solution of being made up of deionized water and given surfactant.Cold then stirring, and be manufactured into other given additive, active substance and auxiliary agent at 60 ℃-25 ℃ by given order if necessary.
Embodiment 1
INCI-name/trade name ????％
Myristyl ether sodium sulfate (Sodium Myreth Sulfate), 27% ????40，00
Cocamido propyl betaine, 31% ????10，00
PEG-5 soyasterol (Generol 122N?E5D) ????1，50
Soyasterol (Generol 122N) ????0，50
Season hydroxyethyl-cellulose-22 ????1，00
Herba Rosmarini Officinalis ????1，00
LAIMENG ????1，00
Lauryl ether-3 ????1，00
?Antil 208 * ????0，50
The EDTA disodium ????0，10
Sodium chloride ????0，68
Antiseptic, dyestuff In right amount
Deionized water Add to 100,00
* acrylate/stearyl ether-50 copolymers+propylene glycol+lauryl ether-3
Embodiment 2
INCI-name/trade name ????％
Sodium laureth sulfate, 28% ????30，00
The cocamidopropyl propyl amide amine oxide, 30% ????10，00
Sodium lauryl sulfate, 90% ????3，50
PEG-5 soyasterol (Generol 122N?E5D) ????1，50
Soyasterol (Generol 122N) ????0，50
Season hydroxyethyl-cellulose-22 ????1，00
Herba Rosmarini Officinalis ????1，00
LAIMENG ????1，00
Lauryl ether-3 ????0，60
?Antil 208 * ????0，20
The EDTA disodium ????0，10
Sodium chloride ????0，51
Antiseptic, dyestuff In right amount
Deionized water Add to 100,00
* acrylate/stearyl ether-50 copolymers+propylene glycol+lauryl ether-3
Embodiment 3
INCI-name/trade name ????％
Ammonium lauryl sulfate, 27% ????10，00
Sodium laureth sulfate, 28% ????30，00
The cocamidopropyl propyl amide amine oxide, 30% ????10，00
PEG-5 soyasterol (Generol 122N?E5D) ????1，50
Soyasterol (Generol 122N) ????0，50
Coconut oleoyl amine MEA ????1，50
Season hydroxyethyl-cellulose-22 ????1，00
Herba Rosmarini Officinalis ????1，00
LAIMENG ????1，00
Glycerol ????3，00
The EDTA disodium ????0，10
Antiseptic, dyestuff, citric acid In right amount
Deionized water Add to 100,00
Embodiment 4
INCI-name/trade name ????％
Sodium laureth sulfate, 28% ????30，00
The cocamidopropyl propyl amide amine oxide, 30% ????10，00
Sodium lauryl sulfate, 90% ????3，50
PEG-5 soyasterol (Generol 122N?E5D) ????1，50
Soyasterol (Generol 122N) ????0，50
Coconut oleoyl amine MEA ????1，50
Season hydroxyethyl-cellulose-22 ????1，00
Eucalyptus globulus Labill ????1，00
Menthae spiralis,herba (Mentha arvensis) ????0，125
Echinacea (Echinacea angustifolia) ????1，00
Glycerol ????3，00
Spice ????0，50
The EDTA disodium ????0，10
Sodium chloride ????0，30
Antiseptic, dyestuff, citric acid In right amount
Deionized water Add to 100,00
Embodiment 5
INCI-name/trade name ????％
The MIPA-lauryl sulfate, 60% ????5，00
Sodium laureth sulfate, 28% ????30，00
The cocamidopropyl propyl amide amine oxide, 30% ????10，00
PEG-5 soyasterol (Generol 122N?E5D) ????1，50
Soyasterol (Generol 122N) ????0，50
Coconut oleoyl amine MEA ????1，00
Season hydroxyethyl-cellulose-22 ????1，00
Glycerol ????3，0
Rhizoma et radix valerianae ????0，08
Herba Cymbopogonis Citrari (Cymbopogon martinii) ????0，15
Citrus (Citrus dulcis) ????0，50
Lavandula angustifolia ????0，15
Lauryl ether-3 ????1，00
Spice ????1，00
The EDTA disodium ????0，10
Antiseptic, dyestuff, citric acid In right amount
Deionized water Add to 100,00
Embodiment 6
INCI-name/trade name ????％
The MIPA-lauryl sulfate, 60% ????10，00
The cocamidopropyl propyl amide amine oxide, 30% ????10，00
Ammonium lauryl sulfate, 27% ????20，00
PEG-5 soyasterol (Generol 122N?E5D) ????1，50
Soyasterol (Generol 122N) ????0，50
Coconut oleoyl amine MEA ????1，50
Season hydroxyethyl-cellulose-22 ????1，00
Eucalyptus globulus Labill ????1，00
The menthae spiralis,herba ????0，125
Echinacea (Echinacea angustifolia) ????1，00
Glycerol ????3，00
?Antil 208 * ????1，50
Spice ????0，50
The EDTA disodium ????0，10
Antiseptic, dyestuff, citric acid In right amount
Deionized water Add to 100,00
*Acrylate/stearyl ether-50 copolymers+propylene glycol+lauryl ether-3
Embodiment 7
INCI-name/trade name ????％
The MIPA-lauryl sulfate, 60% ????5，00
Sodium laureth sulfate, 28% ????30，00
The cocamidopropyl propyl amide amine oxide, 30% ????10，00
PEG-5 soyasterol (Generol 122N?E5D) ????1，50
Soyasterol (Generol 122N) ????0，50
Coconut oleoyl amine MEA ????1，50
Season hydroxyethyl-cellulose-22 ????1，00
Herba Rosmarini Officinalis ????1，00
LAIMENG ????1，00
Glycerol ????3，00
?Antil 208 * ????1，00
Spice ????0，50
The EDTA disodium ????0，10
Antiseptic, dyestuff, citric acid In right amount
Deionized water Add to 100,00
*Acrylate/stearyl ether-50 copolymers+propylene glycol+lauryl ether-3
Embodiment 8
INCI-name/trade name ????％
The MIPA-lauryl sulfate, 60% ????20，00
The cocamidopropyl propyl amide amine oxide, 30% ????10，00
PEG-5 soyasterol (Generol 122N?E5D) ????1，50
Soyasterol (Generol 122N) ????0，50
Coconut oleoyl amine MEA ????1，50
Season hydroxyethyl-cellulose-22 ????1，00
Eucalyptus globulus Labill ????1，00
The menthae spiralis,herba ????0，125
Echinacea (Echinacea angustifolia) ????1，00
Glycerol ????3，00
Antil 208 * ????1，50
Spice ????0，50
The EDTA disodium ????0，10
Antiseptic, dyestuff, citric acid In right amount
Deionized water Add to 100,00
*Acrylate/stearyl ether-50 copolymers+propylene glycol+lauryl ether-3
Embodiment 9
INCI-name/trade name ????％
Zetesol AP, 24% ????10，00
The cocamidopropyl propyl amide amine oxide, 30% ????10，00
Ammonium lauryl sulfate, 27% ????20，00
PEG-5 soyasterol (Generol 122N?E5D) ????1，50
Soyasterol (Generol 122N) ????0，50
Coconut oleoyl amine MEA ????1，50
Season hydroxyethyl-cellulose-22 ????1，00
Methyl nicotinate ????0，005
The ethylene glycol salicylate ????1，00
The Huang Sweden Juniperus oxycedrus that crawls ????0，10
Pinus ????0，40
Herba Rosmarini Officinalis ????0，40
Rhizoma Zingiberis Recens ????0，20
Glycerol ????3，00
?Antil 208 * ????0，50
Spice ????0，50
The EDTA disodium ????0，10
Antiseptic, dyestuff, citric acid In right amount
Deionized water Add to 100,00
*The proof of liposome structure in acrylate/stearyl ether-50 copolymers+propylene glycol+lauryl ether-3II. preparation of the present invention
The preparation that obtains by embodiment 1-9 has been described by transmission electron microscope observed liposome structure (spherical body) behind freeze fracture in following visual 1-9.
The tabulation of TEM picture
Embodiment 1=the 2778th
Embodiment 2=the 2831st
Embodiment 3=the 2841st
Embodiment 4=the 2726th
Embodiment 5=the 2922nd
Embodiment 6=the 2928th
Embodiment 7=the 2925th
Embodiment 8=the 2913rd
Embodiment 9=the 2952nd

Claims (13)

1. preparation of aqueous-based cleaning, contain 1-60% one or more be selected from the surfactant of anionic and/or nonionic and/or amphoteric and/or cationic surface active agent, 0-5% one or more regulators, 0-5% one or more stabilizing agents, 0-3% one or more antiseptic, 0-5% one or more thickening agents and 0-20% active substance, 0-1% dyestuff and 0-5% one or more turbidity inducing agents or pearling agent, it is characterized by, detergent compositions contains 0.001-15% one or more sterols.
2. the detergent compositions of claim 1 is characterized by, and it is a kind of bath foam, foam bath compositions or shampoo.
3. claim 1 or 2 detergent compositions is characterized by, and contain one or more plant sterols as sterol.
4. claim 1 or 2 detergent compositions is characterized by, and as sterol, containing ethoxylation degree is the ethoxylation sterol of 5-30 (EO).
5. claim 1 or 2 detergent compositions is characterized by, and it contains the mixture of being made up of a kind of sterol and a kind of ethoxylation sterol.
6. the detergent compositions of claim 5 is characterized by, and the umber of ethoxylation sterol is greater than or equal to the umber of non-ethoxylated sterol.
7. the detergent compositions of one of claim 1-6 is characterized by, and it contains the mixture by anionic and amphoteric or anionic and nonionic surfactant.
8. the detergent compositions of one of claim 1-7 is characterized by, and anion surfactant is selected from alkyl sulfate, alkyl ether sulfate, sulfosuccinate, sulphosuccinamate, sarcosinate, isethionate, taurate, the ether carboxylic acid, albumen-fatty acid condensation substance, alkylsulfonate, as alkylbenzenesulfonate, MAP, monoglyceride sulfate, amide ether sulfate, alkyl sulfoacetate, alpha-alkene sulfonate, amphoteric surfactant are selected from alkyl aminopropionic acid salt, alkyl-, alkyl amido-, sulfobetaines, alkyl glycinate and non-ionic surface active agent are selected from alkanolamide, fatty acid ethoxylate, alcohol ethoxylate, alkyl polyglucoside, amine oxide, sorbitan esters, alkylphenol ethoxylate, the mixing condensation polymer of oxirane and expoxy propane.
9. the detergent compositions of one of claim 1 to 8 is characterized by, and it contains 10-25% surfactant.
10. the detergent compositions of one of claim 1 to 9 is characterized by, and it contains 0.5-5% sterol and/or ethoxylation sterol.
11. the detergent compositions of one of claim 1-10 is characterized by, it contains 0.01-5% lecithin, phosphatidylcholine, sheath lipoid and/or ceramide.
12. the method for the detergent compositions of one of preparation claim 1 to 11, it is characterized by, the solution of preparation water and surfactant, it is heated to the fusing point of sterol, sterol is melted in wherein, with the cold stirring of mixture, can also add other additive, auxiliary agent and active substance down at 60 ℃-25 ℃ afterwards then.
13. the detergent compositions of one of claim 1 to 11 is in the purposes aspect washing colloids, bath foam, bubble bath or shampoo.
CN99813757A 1998-11-27 1999-11-09 Preparation of aqueous-based cleaning agents which form vesicles and which contain active agents, method for their production and their utilization Pending CN1328444A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19854827A DE19854827A1 (en) 1998-11-27 1998-11-27 Water-based vesicle-forming surfactant-containing cleaning preparations, process for their preparation and their use
DE19854827.3 1998-11-27

Publications (1)

Publication Number Publication Date
CN1328444A true CN1328444A (en) 2001-12-26

Family

ID=7889266

Family Applications (1)

Application Number Title Priority Date Filing Date
CN99813757A Pending CN1328444A (en) 1998-11-27 1999-11-09 Preparation of aqueous-based cleaning agents which form vesicles and which contain active agents, method for their production and their utilization

Country Status (22)

Country Link
EP (1) EP1133276A1 (en)
JP (1) JP2002531389A (en)
KR (1) KR20010080615A (en)
CN (1) CN1328444A (en)
AP (1) AP2001002158A0 (en)
AU (1) AU760248B2 (en)
BG (1) BG105533A (en)
BR (1) BR9915742A (en)
CA (1) CA2352288A1 (en)
CZ (1) CZ20011867A3 (en)
DE (1) DE19854827A1 (en)
EA (1) EA003465B1 (en)
HR (1) HRP20010400A2 (en)
HU (1) HUP0104356A3 (en)
IL (1) IL142877A0 (en)
NO (1) NO20012578L (en)
NZ (1) NZ511785A (en)
PL (1) PL347886A1 (en)
SK (1) SK7092001A3 (en)
TR (1) TR200101508T2 (en)
WO (1) WO2000032161A1 (en)
YU (1) YU36101A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109414386A (en) * 2016-04-26 2019-03-01 皮斯卡桑(国际)有限公司 personal cleansing composition
CN110408489A (en) * 2019-08-21 2019-11-05 湖北中烟工业有限责任公司 Cleaning agent for electric heating cigarette heater

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY158895A (en) 2000-05-19 2016-11-30 Monsanto Technology Llc Potassium glyphosate formulations
DE10204526A1 (en) * 2002-02-05 2003-08-07 Beiersdorf Ag Cosmetic and/or dermatological preparations (especially of 'leave-on' type) for skin care or treatment contain eucalyptus oil together with electrolytes and a polyol or urea
DE10231736A1 (en) * 2002-07-13 2004-02-12 Merz Pharma Gmbh & Co. Kgaa Vesicle-forming surfactant-containing cleaning preparation with a high active ingredient content, process for its preparation and its use
FR2848830B1 (en) * 2002-12-19 2005-05-13 Oreal COSMETIC COMPOSITIONS CONTAINING AN AMPHOTERIC SURFACTANT AND A NACRANT AGENT AND USES THEREOF
DE10344527A1 (en) 2003-09-25 2005-04-21 Beiersdorf Ag Foaming preparations with yield point
JP2006124300A (en) * 2004-10-27 2006-05-18 Takasago Internatl Corp Vesicle preparation
JP4563194B2 (en) * 2005-01-21 2010-10-13 ポーラ化成工業株式会社 Composition for external use
JP5525859B2 (en) * 2010-02-26 2014-06-18 株式会社ピーアンドピーエフ Solid cleaning composition
DE102010054461A1 (en) 2010-12-14 2012-06-14 Merz Pharma Gmbh & Co. Kgaa Liposome-forming aqueous bath preparations with high active ingredient content and their cosmetic / dermatological / medical application
GB2552864B (en) * 2016-04-26 2021-07-07 Pz Cussons Int Ltd Aerosol gel composition
GB2553608B (en) * 2016-04-26 2021-03-10 Pz Cussons Int Ltd Post-foaming mild cleansing composition

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU1528494A1 (en) * 1987-02-06 1989-12-15 Всесоюзный научно-исследовательский и проектный институт химической промышленности Washing agent for body
FR2655540B1 (en) * 1989-12-13 1994-02-11 Oreal COSMETIC COMPOSITION FOR HAIR CARE AND USE OF THE SAME.
GB9207637D0 (en) * 1991-04-24 1992-05-27 Kao Corp Milky detergent composition for hard surfaces
DE4205548C3 (en) * 1992-02-24 1998-07-23 Merz & Co Gmbh & Co Bath and shower additive with vesicle-forming properties, its production and use
DE4402527A1 (en) * 1994-01-28 1995-08-03 Henkel Kgaa Aqueous solutions of esterquats
US5543074A (en) * 1994-02-18 1996-08-06 Chesebrough-Pond's Usa Co., Div. Of Conopco, Inc. Personal washing compositions
GB9421185D0 (en) * 1994-10-20 1994-12-07 Unilever Plc Personal car composition

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109414386A (en) * 2016-04-26 2019-03-01 皮斯卡桑(国际)有限公司 personal cleansing composition
CN110408489A (en) * 2019-08-21 2019-11-05 湖北中烟工业有限责任公司 Cleaning agent for electric heating cigarette heater

Also Published As

Publication number Publication date
BR9915742A (en) 2001-08-14
SK7092001A3 (en) 2001-12-03
DE19854827A1 (en) 2000-06-08
HUP0104356A3 (en) 2002-12-28
TR200101508T2 (en) 2002-03-21
KR20010080615A (en) 2001-08-22
AU760248B2 (en) 2003-05-08
HRP20010400A2 (en) 2002-06-30
BG105533A (en) 2001-12-31
IL142877A0 (en) 2002-03-10
PL347886A1 (en) 2002-04-22
NZ511785A (en) 2002-11-26
AP2001002158A0 (en) 2001-05-09
NO20012578L (en) 2001-07-02
YU36101A (en) 2003-12-31
AU1505100A (en) 2000-06-19
NO20012578D0 (en) 2001-05-25
JP2002531389A (en) 2002-09-24
EP1133276A1 (en) 2001-09-19
HUP0104356A2 (en) 2002-03-28
EA200100594A1 (en) 2001-12-24
CZ20011867A3 (en) 2001-10-17
CA2352288A1 (en) 2000-06-08
WO2000032161A1 (en) 2000-06-08
EA003465B1 (en) 2003-06-26

Similar Documents

Publication Publication Date Title
RU2493819C2 (en) Compositions of structured surface-active substance
US7749951B2 (en) Enhanced oil delivery from structured surfactant formulations
US6977238B1 (en) Method for making stable aqueous foaming surfactant
CN101119768A (en) Cleansing composition comprising hydrophobic benefit agent pre-emulsified with colloidal cationic particles
JP2004512347A (en) Transparent aqueous composition containing hydrophobic silicone oil
CN1328444A (en) Preparation of aqueous-based cleaning agents which form vesicles and which contain active agents, method for their production and their utilization
JP6141501B1 (en) Gel composition
CN110283668A (en) A kind of surface activator composition and its preparation method and application improving detergent foam performance
JP4106184B2 (en) Transparent personal care formulations containing quaternary ammonium compounds and other nitrogen-containing compounds
BRPI0711239B1 (en) Cleaning composition.
CN101797212A (en) Hydrophilic and oleophilic composite
JP2018083769A (en) Production methods of liquid crystal mixed-crystal emulsion composition, liquid crystal emulsion cosmetic, and liquid crystal mixed-crystal emulsion composition, as well as production method of liquid crystal milk cosmetic
CN117695164A (en) Cleaning composition containing lamellar structured surfactant system and use thereof
JPH09316488A (en) Concentrated liquid detergent composition
JP2004512350A (en) Composition comprising a hydrophobic silicone oil and ethoxylated glycerides
JP3924971B2 (en) Cleaning composition and method for producing the same
KR20150062447A (en) Skin cleaning compostion having high moisturinzing and high foaming effect
KR20260007194A (en) Biosurfactant composition and method for producing the same
DE10231736A9 (en) Vesicle-forming surfactant-containing cleaning preparation with a high active ingredient content, process for its preparation and its use
US9931287B2 (en) Simple micro-particulate suspension of behentrimonium chloride with favorable distributive and adsorptive properties
SURFACTANTS Vegetable-derived surfactants as a reply to the natural trand in the household and personal care
JP2015086149A (en) Fine emulsion composition for oral cavity and liquid composition for oral cavity containing the same

Legal Events

Date Code Title Description
C06 Publication
C10 Entry into substantive examination
PB01 Publication
SE01 Entry into force of request for substantive examination
C02 Deemed withdrawal of patent application after publication (patent law 2001)
WD01 Invention patent application deemed withdrawn after publication
REG Reference to a national code

Ref country code: HK

Ref legal event code: GR

Ref document number: 1078626

Country of ref document: HK