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CN1324235A - 小粒径异维生素a酸的组合物及制备方法 - Google Patents

小粒径异维生素a酸的组合物及制备方法 Download PDF

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Publication number
CN1324235A
CN1324235A CN99812404A CN99812404A CN1324235A CN 1324235 A CN1324235 A CN 1324235A CN 99812404 A CN99812404 A CN 99812404A CN 99812404 A CN99812404 A CN 99812404A CN 1324235 A CN1324235 A CN 1324235A
Authority
CN
China
Prior art keywords
accutane
float
dosage form
grease
unit dose
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN99812404A
Other languages
English (en)
Chinese (zh)
Inventor
哈希姆·A·艾哈迈德
马丁·霍华德·因费尔德
纳夫尼特·哈格温德斯·沙阿
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of CN1324235A publication Critical patent/CN1324235A/zh
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/203—Retinoic acids ; Salts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dermatology (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN99812404A 1998-10-30 1999-10-29 小粒径异维生素a酸的组合物及制备方法 Pending CN1324235A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10633198P 1998-10-30 1998-10-30
US60/106,331 1998-10-30

Publications (1)

Publication Number Publication Date
CN1324235A true CN1324235A (zh) 2001-11-28

Family

ID=22310843

Family Applications (1)

Application Number Title Priority Date Filing Date
CN99812404A Pending CN1324235A (zh) 1998-10-30 1999-10-29 小粒径异维生素a酸的组合物及制备方法

Country Status (13)

Country Link
EP (1) EP1131068A1 (es)
JP (1) JP2002528492A (es)
KR (1) KR20010073226A (es)
CN (1) CN1324235A (es)
AR (1) AR020999A1 (es)
AU (1) AU1044400A (es)
BR (1) BR9914932A (es)
CA (1) CA2347098A1 (es)
NO (1) NO20012014L (es)
PE (1) PE20001227A1 (es)
TR (1) TR200101156T2 (es)
WO (1) WO2000025772A1 (es)
ZA (1) ZA200102731B (es)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100594894C (zh) * 2003-11-03 2010-03-24 巴斯利尔药物股份公司 含类视色素的软明胶胶囊用新型配制剂

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US7374779B2 (en) 1999-02-26 2008-05-20 Lipocine, Inc. Pharmaceutical formulations and systems for improved absorption and multistage release of active agents
DE19932157A1 (de) * 1999-07-13 2001-01-18 Pharmasol Gmbh Verfahren zur schonenden Herstellung von hochfeinen Mikropartikeln und Nanopartikeln
FR2807662A1 (fr) * 2000-04-12 2001-10-19 Cll Pharma Procede pour stabiliser la granulometrie d'un principe actif verulent disperse dans un liquide et ses applications
IN192188B (es) * 2000-06-16 2004-03-13 Ranbaxy Lab Ltd
US7435427B2 (en) 2000-09-22 2008-10-14 Galephar M/F Pharmaceutical semi-solid composition of isotretinoin
EA200400782A1 (ru) * 2001-12-06 2005-08-25 Рэнбакси Лабораториз Лимитед Композиция изотретиноина с измельчением компонентов до степени наночастиц
SE0303135D0 (sv) * 2003-11-25 2003-11-25 Lipocore Holding Ab Controlled food effect composition
CZ300424B6 (cs) * 2006-06-20 2009-05-13 Pliva - Lachema A. S. Farmaceutická kompozice pro perorální podání
WO2008099615A1 (ja) 2007-02-16 2008-08-21 Aska Pharmaceutical Co., Ltd. 微粒子油性懸濁液を含む医薬組成物
US11304960B2 (en) 2009-01-08 2022-04-19 Chandrashekar Giliyar Steroidal compositions
WO2010109259A1 (es) * 2009-03-26 2010-09-30 Grufarcol Ltda Métoda para preparar formulaciones de gel blando de isotretinoína líquida y la formulaciones obtenidas
US10022348B2 (en) 2009-05-20 2018-07-17 Sun Pharmaceutical Industries Limited Topical solution of isotretinoin
SG176097A1 (en) 2009-05-20 2011-12-29 Ranbaxy Lab Ltd Topical retinoid solutions
US20120259013A1 (en) 2009-05-20 2012-10-11 Ranbaxy Laboratories Limited Liquid dosage forms of isotretinoin
US9358241B2 (en) 2010-11-30 2016-06-07 Lipocine Inc. High-strength testosterone undecanoate compositions
US9034858B2 (en) 2010-11-30 2015-05-19 Lipocine Inc. High-strength testosterone undecanoate compositions
US20120148675A1 (en) 2010-12-10 2012-06-14 Basawaraj Chickmath Testosterone undecanoate compositions
US9078925B2 (en) 2012-06-18 2015-07-14 Galephar Pharmaceutical Research, Inc. Pharmaceutical semi-solid composition of isotretinoin
JP6018845B2 (ja) * 2012-09-03 2016-11-02 三生医薬株式会社 超微粉末含有カプセル剤の製造方法
MX2016015465A (es) 2014-05-29 2017-03-27 Sun Pharmaceutical Ind Ltd Composicion farmaceutica oral de isotretinoina.
JP2017516794A (ja) * 2014-06-02 2017-06-22 サン ファーマシューティカル インダストリーズ リミテッドＳｕｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌ Ｉｎｄｕｓｔｒｉｅｓ Ｌｔｄ． 経口イソトレチノイン医薬組成物
BR112017001963A2 (pt) 2014-07-31 2017-11-21 Sun Pharmaceutical Ind Ltd composição farmacêutica oral, seu processo de preparação e método de tratamento
US9498485B2 (en) 2014-08-28 2016-11-22 Lipocine Inc. Bioavailable solid state (17-β)-hydroxy-4-androsten-3-one esters
US20170246187A1 (en) 2014-08-28 2017-08-31 Lipocine Inc. (17-ß)-3-OXOANDROST-4-EN-17-YL TRIDECANOATE COMPOSITIONS AND METHODS OF THEIR PREPARATION AND USE
US9750711B2 (en) * 2014-10-01 2017-09-05 Sun Pharmaceutical Industries Limited Low dose oral pharmaceutical composition of isotretinoin
MA40781A (fr) * 2014-10-01 2017-08-08 Sun Pharmaceutical Ind Ltd Composition pharmaceutique d'isotrétinoïne à faible dosage destinée à la voie orale
CA2987177A1 (en) * 2015-05-25 2016-12-01 Sun Pharmaceutical Industries Limited Once-daily oral pharmaceutical composition of isotretinoin
WO2017203365A1 (en) 2016-05-26 2017-11-30 Dr. Reddy's Laboratiories Ltd. Pharmaceutical compositions for treating acne
CA3078723A1 (en) 2016-11-28 2018-05-31 Nachiappan Chidambaram Oral testosterone undecanoate therapy
US12150945B2 (en) 2018-07-20 2024-11-26 Lipocine Inc. Liver disease
JP2025534534A (ja) 2022-07-01 2025-10-16 アクロテック バイオファーマ インコーポレーティド イソトレチノインを含む医薬組成物、その調製のためのプロセス及びその使用
WO2024236523A1 (en) 2023-05-16 2024-11-21 Sun Pharmaceutical Industries Limited Once daily isotretinoin composition

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2557615C2 (de) * 1975-12-20 1985-08-14 Bayer Ag, 5090 Leverkusen Neue Niclosamid-Suspensionsformulierungen
DE3119383A1 (de) * 1981-05-15 1982-12-02 Basf Ag, 6700 Ludwigshafen Verfahren zur herstellung von feinverteilten, pulverfoermigen carotinodpraeparaten
CA1282326C (en) * 1984-12-14 1991-04-02 Paul J. Jarosz Pharmaceutical composition containing 13-cis vitamin a acid as the active ingredient

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100594894C (zh) * 2003-11-03 2010-03-24 巴斯利尔药物股份公司 含类视色素的软明胶胶囊用新型配制剂

Also Published As

Publication number Publication date
BR9914932A (pt) 2001-07-10
NO20012014D0 (no) 2001-04-24
EP1131068A1 (en) 2001-09-12
AR020999A1 (es) 2002-06-05
WO2000025772A1 (en) 2000-05-11
AU1044400A (en) 2000-05-22
PE20001227A1 (es) 2000-11-06
CA2347098A1 (en) 2000-05-11
TR200101156T2 (tr) 2001-08-21
ZA200102731B (en) 2002-07-03
NO20012014L (no) 2001-04-24
JP2002528492A (ja) 2002-09-03
KR20010073226A (ko) 2001-07-31

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C06 Publication
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C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C02 Deemed withdrawal of patent application after publication (patent law 2001)
WD01 Invention patent application deemed withdrawn after publication