CN1381242A - Capsule for treating depression - Google Patents
Capsule for treating depression Download PDFInfo
- Publication number
- CN1381242A CN1381242A CN 01107355 CN01107355A CN1381242A CN 1381242 A CN1381242 A CN 1381242A CN 01107355 CN01107355 CN 01107355 CN 01107355 A CN01107355 A CN 01107355A CN 1381242 A CN1381242 A CN 1381242A
- Authority
- CN
- China
- Prior art keywords
- capsule
- depression
- radix
- herba hyperici
- acanthopanacis senticosi
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000002775 capsule Substances 0.000 title claims abstract description 12
- 239000000796 flavoring agent Substances 0.000 claims description 5
- 235000019634 flavors Nutrition 0.000 claims description 5
- 229940126678 chinese medicines Drugs 0.000 claims description 4
- 208000020401 Depressive disease Diseases 0.000 claims description 3
- 239000000203 mixture Substances 0.000 claims description 3
- 239000003814 drug Substances 0.000 abstract description 10
- 230000000694 effects Effects 0.000 abstract description 6
- 241000555682 Forsythia x intermedia Species 0.000 abstract 1
- 239000002552 dosage form Substances 0.000 abstract 1
- 235000013399 edible fruits Nutrition 0.000 abstract 1
- 238000012216 screening Methods 0.000 abstract 1
- 210000000952 spleen Anatomy 0.000 description 6
- 210000003734 kidney Anatomy 0.000 description 5
- 238000002360 preparation method Methods 0.000 description 4
- QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- 239000000935 antidepressant agent Substances 0.000 description 3
- 229940005513 antidepressants Drugs 0.000 description 3
- 201000010099 disease Diseases 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 210000005036 nerve Anatomy 0.000 description 3
- 238000012856 packing Methods 0.000 description 3
- 239000000843 powder Substances 0.000 description 3
- 230000001430 anti-depressive effect Effects 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 230000007812 deficiency Effects 0.000 description 2
- 238000007877 drug screening Methods 0.000 description 2
- 238000012545 processing Methods 0.000 description 2
- 230000001131 transforming effect Effects 0.000 description 2
- 241000546193 Clusiaceae Species 0.000 description 1
- 241001632410 Eleutherococcus senticosus Species 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 208000028017 Psychotic disease Diseases 0.000 description 1
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 description 1
- 229940123445 Tricyclic antidepressant Drugs 0.000 description 1
- 230000036528 appetite Effects 0.000 description 1
- 235000019789 appetite Nutrition 0.000 description 1
- 206010003549 asthenia Diseases 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 230000000881 depressing effect Effects 0.000 description 1
- 230000003001 depressive effect Effects 0.000 description 1
- 230000000994 depressogenic effect Effects 0.000 description 1
- 238000002651 drug therapy Methods 0.000 description 1
- 230000008451 emotion Effects 0.000 description 1
- 238000002481 ethanol extraction Methods 0.000 description 1
- 235000008216 herbs Nutrition 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 206010022437 insomnia Diseases 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 206010025482 malaise Diseases 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000008506 pathogenesis Effects 0.000 description 1
- 208000037920 primary disease Diseases 0.000 description 1
- 238000011112 process operation Methods 0.000 description 1
- 230000003014 reinforcing effect Effects 0.000 description 1
- 238000004904 shortening Methods 0.000 description 1
- 238000001694 spray drying Methods 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 239000003029 tricyclic antidepressant agent Substances 0.000 description 1
- 238000003809 water extraction Methods 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Abstract
A Chinese medicine in the dosage form of capsule for treating depression is prepared from forsythia fruit and acanthopanax bark through screening, pretreating, extracting and mixing. Its advantages are sure curative effect, and low by-effect.
Description
The present invention relates to a kind of Chinese medicine preparation, especially a kind of Chinese medicinal capsule for the treatment of depression.
Depression is the commonly encountered diseases of modern society, belongs to the emotion psychosis, is principal character with depressed, worried sorrow, appetite decline, insomnia, tired etc.In modern society, this disease has had a strong impact on people's work, quality of life.WHO estimates that the whole world has 3.4 hundred million people patients that in various degree depression is arranged approximately, and about 1/3rd people occurred slight clinical symptoms in life at it, expected the year two thousand twenty, and depression will be the harm humans second largest disease in healthy shortening life-span.China adds up recently, and the sickness rate of depression is 5%-8%.From investigation and analysis, estimate annual newly-increased about 100-150 ten thousand depressive patients of China, along with the aggravation of social competition, this type of patient's quantity will be the trend that rises year by year.
At present, the medicine of clinical treatment depression is many based on chemical drugs both at home and abroad, presses down compositions class medicine, tricyclic antidepressant, Fourth Ring class antidepressants as selectivity 5-hydroxy tryptamine (5-HT) reuptake.These Drug therapys have multiple higher side effect and more contraindication, patient can not be tolerated and be difficult to reach promising result.Therefore, people begin target diversion Chinese medicine antidepressant.
The objective of the invention is to: for overcoming the defective of above-mentioned chemicals, provide a kind of curative effect suitable with similar depression chemical drugs, side effect is low, the Chinese medicinal capsule that contraindication is few.
Solution of the present invention is according to the Chinese medical discrimination theory, causes strongly fragrantly from fire mutually, and asthenia of both the spleen and kidney is started with, and drafts clearing away heat-fire, and dissipating depression of QI is calmed the nerves, and kidney and spleen invigorating is the Therapeutic Principle of primary disease.Therefore, the present invention treats capsule employing Herba Hyperici perforati, the Radix Et Caulis Acanthopanacis Senticosi two flavor Chinese medicines of depression.Herba Hyperici perforati is a principal agent, the merit that has the dissipating depression of QI of relieving inflammation or internal heat, yin nourishing to calm the nerves, and it is primarily aimed at stagnated QI transforming into fire, fire causes strongly fragrant main pathogenesis mutually; Radix Et Caulis Acanthopanacis Senticosi is an accessory drugs, and replenishing QI to invigorate the spleen is arranged, the merit of tonifying the kidney for tranquilization, and auxiliary principal agent performance tonify deficiency is set upright, reinforcing and reducing are used together, giving consideration to both the incidental and fundamental, play clearing away heat-fire altogether, and dissipating depression of QI is calmed the nerves, the merit of kidney and spleen invigorating.
The present invention adopts by Herba Hyperici perforati, Radix Et Caulis Acanthopanacis Senticosi two flavor Chinese medicines and forms by a certain percentage, and the percentage by weight of its composition is as follows:
Herba Hyperici perforati 35-50% Radix Et Caulis Acanthopanacis Senticosi 50-65%
Below with reference to example the present invention is further described:
Embodiment 1
Herba Hyperici perforati 43% Radix Et Caulis Acanthopanacis Senticosi 57%
Embodiment 1 is optimum weight percentage ratio of the present invention.
Process chart:
Drug screening → process → extract → be mixed → packing warehouse-in
Specification:
1, drug screening: Herba Hyperici perforati (according to 1977 editions " Chinese medicine dictionaries ") is the herb of Guttiferae plant Herba Hyperici perforati Hyppericum perforatum L.
Radix Et Caulis Acanthopanacis Senticosi (according to 2000 editions " one one of Chinese pharmacopoeia) be the dry root and rhizome of stems and leaves of acanthopanax senticosus (Rupr.et Maxim.) Harms.
2, processing: Herba Hyperici perforati is made the section sheet of 10-15 millimeter, and Radix Et Caulis Acanthopanacis Senticosi is made the thin slice of 1-2 millimeter.
3, extract: 75% ethanol extraction that Herba Hyperici perforati is doubly measured with 8-10 3 times, each 1 hour; The water extraction that Radix Et Caulis Acanthopanacis Senticosi is doubly measured with 8-10 3 times, each 1 hour.Extract concentrates, spray drying, makes extract powder.
4, be mixed: get extract powder according to said ratio and be mixed.
5, packing warehouse-in: extract powder is incapsulated, and every heavy 0.3 restrains or is pressed into tablet packing warehouse-in.
Embodiment 2
Herba Hyperici perforati 40% Radix Et Caulis Acanthopanacis Senticosi 60%
Its technological process operation is with example 1
But the capsule clearing away heat-fire of treatment depression among the present invention, resolving stagnation for tranquilization, kidney and spleen invigorating.Be used for stagnated QI transforming into fire, spirit depressing due to the deficiency of spleen and stomach.
Advantage of the present invention is:
1, capsule preparations of the present invention is according to the Chinese medical discrimination theory, demonstrates fully the organic conception of the traditional Chinese medical science, sample Double controlling, so curative effect is reliable.
2, with respect to similar antidepressant chemicals, it is low to have a side effect, the characteristics that contraindication is few.
3, this capsule preparations is made up of two flavor Chinese medicines, this two flavors The traditional Chinese medicine medicinal herbs resource abundance.
4, this capsule preparations manufacture method is simple, processing ease.
5, the present invention is a capsule, takes and easy to carry.
Claims (1)
1, a kind of capsule for the treatment of depression is characterized in that: be made up of Herba Hyperici perforati, Radix Et Caulis Acanthopanacis Senticosi two flavor Chinese medicines, the percentage by weight of its composition is as follows:
Herba Hyperici perforati 35-50% Radix Et Caulis Acanthopanacis Senticosi 50-65%
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB011073551A CN1169536C (en) | 2001-04-16 | 2001-04-16 | Capsule for treating depression |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB011073551A CN1169536C (en) | 2001-04-16 | 2001-04-16 | Capsule for treating depression |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1381242A true CN1381242A (en) | 2002-11-27 |
| CN1169536C CN1169536C (en) | 2004-10-06 |
Family
ID=4656292
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB011073551A Expired - Lifetime CN1169536C (en) | 2001-04-16 | 2001-04-16 | Capsule for treating depression |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1169536C (en) |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006005219A1 (en) * | 2004-05-27 | 2006-01-19 | Chengdu Kanghong Technology Enterprises (Group) Co., Ltd. | A pharmaceutical composition for treating depression and the process for preparing the same |
| CN103070891A (en) * | 2011-10-26 | 2013-05-01 | 成都康弘药业集团股份有限公司 | Capsule containing Hypericum perforatum extract |
| CN103127467A (en) * | 2013-03-06 | 2013-06-05 | 李翠霞 | Traditional Chinese medicine for treating depression |
| CN103768114A (en) * | 2012-10-23 | 2014-05-07 | 成都康弘药业集团股份有限公司 | Application of pharmaceutical composition in preparation of medicines used for treating or preventing cerebral apoplexy |
| CN109700973A (en) * | 2019-02-28 | 2019-05-03 | 何原 | A kind of regenerated Chinese medicine composition of promotion Hippocampal Neuron Cells |
| CN110780004A (en) * | 2019-11-14 | 2020-02-11 | 美国琛蓝营养制品股份有限公司 | Method for establishing fingerprint of traditional Chinese medicine composition or preparation thereof with depression mood regulating effect |
| CN110772564A (en) * | 2019-11-14 | 2020-02-11 | 美国琛蓝营养制品股份有限公司 | Traditional Chinese medicine extract composition with depression mood regulating effect, preparation method thereof and traditional Chinese medicine preparation |
| CN118021902A (en) * | 2024-02-05 | 2024-05-14 | 情志健康管理(上海)有限公司 | Composition for preventing and treating depression |
-
2001
- 2001-04-16 CN CNB011073551A patent/CN1169536C/en not_active Expired - Lifetime
Cited By (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006005219A1 (en) * | 2004-05-27 | 2006-01-19 | Chengdu Kanghong Technology Enterprises (Group) Co., Ltd. | A pharmaceutical composition for treating depression and the process for preparing the same |
| CN103070891B (en) * | 2011-10-26 | 2014-12-24 | 成都康弘药业集团股份有限公司 | Capsule containing Hypericum perforatum extract |
| CN103070891A (en) * | 2011-10-26 | 2013-05-01 | 成都康弘药业集团股份有限公司 | Capsule containing Hypericum perforatum extract |
| CN103768114B (en) * | 2012-10-23 | 2017-12-19 | 成都康弘药业集团股份有限公司 | A kind of application of pharmaceutical composition in the medicine for treating or preventing cerebral apoplexy is prepared |
| CN103768114A (en) * | 2012-10-23 | 2014-05-07 | 成都康弘药业集团股份有限公司 | Application of pharmaceutical composition in preparation of medicines used for treating or preventing cerebral apoplexy |
| CN103127467B (en) * | 2013-03-06 | 2014-07-09 | 李翠霞 | Traditional Chinese medicine for treating depression |
| CN103127467A (en) * | 2013-03-06 | 2013-06-05 | 李翠霞 | Traditional Chinese medicine for treating depression |
| CN109700973A (en) * | 2019-02-28 | 2019-05-03 | 何原 | A kind of regenerated Chinese medicine composition of promotion Hippocampal Neuron Cells |
| CN109700973B (en) * | 2019-02-28 | 2021-06-22 | 何原 | Traditional Chinese medicine composition for promoting regeneration of hippocampal neuronal cells |
| CN110780004A (en) * | 2019-11-14 | 2020-02-11 | 美国琛蓝营养制品股份有限公司 | Method for establishing fingerprint of traditional Chinese medicine composition or preparation thereof with depression mood regulating effect |
| CN110772564A (en) * | 2019-11-14 | 2020-02-11 | 美国琛蓝营养制品股份有限公司 | Traditional Chinese medicine extract composition with depression mood regulating effect, preparation method thereof and traditional Chinese medicine preparation |
| WO2021093090A1 (en) * | 2019-11-14 | 2021-05-20 | 美国琛蓝营养制品股份有限公司 | Traditional chinese medicine extract composition having function of regulating depression, preparation method therefor, and chinese medicine preparation |
| WO2021093091A1 (en) * | 2019-11-14 | 2021-05-20 | 美国琛蓝营养制品股份有限公司 | Method for establishing fingerprint spectrum of traditional chinese medicine composition having effect of regulating low mood or preparation thereof |
| US20230125425A1 (en) * | 2019-11-14 | 2023-04-27 | Chenland Nutritionals, Inc. | Traditional chinese medicine extract composition with function of regulating depressive emotion and preparation method and traditional chinese medicine preparation thereof |
| CN118021902A (en) * | 2024-02-05 | 2024-05-14 | 情志健康管理(上海)有限公司 | Composition for preventing and treating depression |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1169536C (en) | 2004-10-06 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Zhao et al. | Scutellaria baicalensis Georgi.(Lamiaceae): a review of its traditional uses, botany, phytochemistry, pharmacology and toxicology | |
| Dasgupta | Antiinflammatory herbal supplements | |
| CN101357219B (en) | Medicine for treating chronic hepatitis B | |
| Kapadia et al. | Inhibitory effect of herbal remedies on 12-O-tetradecanoylphorbol-13-acetate-promoted Epstein–Barr virus early antigen activation | |
| Guo et al. | Antidepressant evaluation of polysaccharides from a Chinese herbal medicine Banxia‐houpu decoction | |
| Yarnell et al. | Clinical botanical medicine | |
| Wagner | Natural products chemistry and phytomedicine in the 21st century: new developments and challenges | |
| Singh et al. | Ethnopharmacological applications targeting alcohol abuse: overview and outlook | |
| CN1169536C (en) | Capsule for treating depression | |
| Prasad et al. | Role of herbs in the management of asthma | |
| Tyagi et al. | Antidiabetic effect of Anacyclus pyrethrum DC in alloxan induced diabetic rats | |
| Kazi-Chishti et al. | Exploring herbal nutraceuticals: unlocking potential in nausea and vomiting prevention-a comprehensive review | |
| CN1682887A (en) | Weight loss and blood lipid lowering preparations | |
| CN1395956A (en) | Chinese medicine for treating depression and anxiety | |
| CN112370515A (en) | Antipyretic Chinese medicinal mixture for treating epidemic common cold, and its preparation method and application | |
| CN1480209A (en) | Method for producing compound preparation of propolis | |
| Okokon et al. | Anti-diabetic and hypolipidaemic activities of Solenostemon monostachyus | |
| Saha et al. | Role of Ayurvedic formulation in digestion | |
| Yang et al. | Analgesic and anti-inflammatory activities and mechanisms of 70% ethanol extract of Zygophyllum macropodum in animals | |
| CN111686224A (en) | Pure Chinese herbal medicine extraction compound oil agent for adjuvant therapy of hypertension, hyperglycemia and hyperlipidemia | |
| Chawke et al. | Ephedra: An anti-asthamatic medicinal plant | |
| CN1183946C (en) | Medicines for treating depression and preparation thereof | |
| CN103768114B (en) | A kind of application of pharmaceutical composition in the medicine for treating or preventing cerebral apoplexy is prepared | |
| CN116942771B (en) | Traditional Chinese medicine composition for treating coronary heart disease and application thereof | |
| Karima | Ethnobotanical research on medicinal plants used for respiratory diseases: results of a survey in Fez, Morocco |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| ASS | Succession or assignment of patent right |
Owner name: CHENGDU KANGHONG TECHNOLOGY INDUSTRIAL (GROUP) CO Free format text: FORMER OWNER: CHENGDU KANGHONG PHARMACEUTICAL CO., LTD. Effective date: 20030306 |
|
| C41 | Transfer of patent application or patent right or utility model | ||
| TA01 | Transfer of patent application right |
Effective date of registration: 20030306 Address after: 610041 new meteorological building, No. three, three South Renmin Road, Chengdu, Sichuan Applicant after: Kanghong Science & Tech. Industrial (Group) Co., Ltd., Chengdu Address before: 610041 new meteorological building, No. three, three South Renmin Road, Chengdu, Sichuan Applicant before: Kanghong Pharmaceutical Co., Ltd., Chengdu |
|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| ASS | Succession or assignment of patent right |
Owner name: CHENGDU KANGHONG MEDICINE GROUP CO.LTD. Free format text: FORMER OWNER: CHENGDU KANGHONG TECHNOLOGY INDUSTRIAL (GROUP) CO., LTD. Effective date: 20080926 |
|
| C41 | Transfer of patent application or patent right or utility model | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20080926 Address after: No 36, Shu West Road, Chengdu, Sichuan, Jinniu District Patentee after: Chengdu Kanghong Pharmaceuticals Group Co., Ltd. Address before: No 36, Shu West Road, Chengdu, Sichuan, Jinniu District Patentee before: Chengdu Kanghong Sci-Tech Industry (Group) Co., Ltd. |
|
| TR01 | Transfer of patent right | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20171101 Address after: 611930, Chengdu, Sichuan, Pengzhou Patentee after: Sichuan Jishengtang Pharmaceutical Co., Ltd. Address before: 610036 Jinniu District, Sichuan, Sichuan West Road, No. 36, No. Patentee before: Chengdu Kanghong Pharmaceuticals Group Co., Ltd. |
|
| CX01 | Expiry of patent term |
Granted publication date: 20041006 |
|
| CX01 | Expiry of patent term |