CN1380044A - New type medical equipment, its control device and special-purpose nano material - Google Patents
New type medical equipment, its control device and special-purpose nano material Download PDFInfo
- Publication number
- CN1380044A CN1380044A CN 02115249 CN02115249A CN1380044A CN 1380044 A CN1380044 A CN 1380044A CN 02115249 CN02115249 CN 02115249 CN 02115249 A CN02115249 A CN 02115249A CN 1380044 A CN1380044 A CN 1380044A
- Authority
- CN
- China
- Prior art keywords
- nano material
- new type
- medical equipment
- control device
- type medical
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000002086 nanomaterial Substances 0.000 title claims abstract description 48
- 238000010438 heat treatment Methods 0.000 claims abstract description 48
- 230000005291 magnetic effect Effects 0.000 claims abstract description 39
- 206010028980 Neoplasm Diseases 0.000 claims abstract description 27
- 230000000694 effects Effects 0.000 claims abstract description 25
- 210000004881 tumor cell Anatomy 0.000 claims abstract description 18
- 230000001575 pathological effect Effects 0.000 claims abstract description 16
- 239000002245 particle Substances 0.000 claims abstract description 9
- 230000009471 action Effects 0.000 claims abstract description 7
- 230000006378 damage Effects 0.000 claims abstract description 7
- 230000006698 induction Effects 0.000 claims description 23
- 238000011282 treatment Methods 0.000 claims description 21
- 238000012544 monitoring process Methods 0.000 claims description 20
- 230000001225 therapeutic effect Effects 0.000 claims description 17
- 238000002560 therapeutic procedure Methods 0.000 claims description 16
- 238000002347 injection Methods 0.000 claims description 13
- 239000007924 injection Substances 0.000 claims description 13
- 238000000034 method Methods 0.000 claims description 11
- 230000008859 change Effects 0.000 claims description 10
- 238000001816 cooling Methods 0.000 claims description 8
- 230000005672 electromagnetic field Effects 0.000 claims description 8
- 238000009792 diffusion process Methods 0.000 claims description 7
- 230000006870 function Effects 0.000 claims description 6
- 230000017074 necrotic cell death Effects 0.000 claims description 6
- 238000002360 preparation method Methods 0.000 claims description 6
- 230000003902 lesion Effects 0.000 claims description 5
- 239000002105 nanoparticle Substances 0.000 claims description 5
- 229910000859 α-Fe Inorganic materials 0.000 claims description 5
- 230000036541 health Effects 0.000 claims description 4
- 239000007788 liquid Substances 0.000 claims description 4
- 239000000463 material Substances 0.000 claims description 4
- MIKKOBKEXMRYFQ-WZTVWXICSA-N meglumine amidotrizoate Chemical compound C[NH2+]C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.CC(=O)NC1=C(I)C(NC(C)=O)=C(I)C(C([O-])=O)=C1I MIKKOBKEXMRYFQ-WZTVWXICSA-N 0.000 claims description 4
- 239000002904 solvent Substances 0.000 claims description 4
- 230000036772 blood pressure Effects 0.000 claims description 3
- 230000004087 circulation Effects 0.000 claims description 3
- 230000001427 coherent effect Effects 0.000 claims description 3
- 239000002826 coolant Substances 0.000 claims description 3
- 238000013523 data management Methods 0.000 claims description 3
- 238000001514 detection method Methods 0.000 claims description 3
- 230000005415 magnetization Effects 0.000 claims description 3
- 238000007726 management method Methods 0.000 claims description 3
- 229910052755 nonmetal Inorganic materials 0.000 claims description 3
- 230000008569 process Effects 0.000 claims description 3
- 210000003701 histiocyte Anatomy 0.000 claims description 2
- 201000011510 cancer Diseases 0.000 abstract description 5
- SZVJSHCCFOBDDC-UHFFFAOYSA-N ferrosoferric oxide Chemical compound O=[Fe]O[Fe]O[Fe]=O SZVJSHCCFOBDDC-UHFFFAOYSA-N 0.000 abstract 2
- 230000000740 bleeding effect Effects 0.000 abstract 1
- 210000001519 tissue Anatomy 0.000 description 27
- 238000000015 thermotherapy Methods 0.000 description 9
- 208000027418 Wounds and injury Diseases 0.000 description 7
- 210000004027 cell Anatomy 0.000 description 7
- 230000001276 controlling effect Effects 0.000 description 6
- 206010020741 Hyperpyrexia Diseases 0.000 description 5
- 206010028851 Necrosis Diseases 0.000 description 5
- 230000017531 blood circulation Effects 0.000 description 5
- 230000000747 cardiac effect Effects 0.000 description 5
- 201000010099 disease Diseases 0.000 description 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 5
- 230000004907 flux Effects 0.000 description 5
- 239000000523 sample Substances 0.000 description 5
- 239000008280 blood Substances 0.000 description 4
- 210000004369 blood Anatomy 0.000 description 4
- 239000002184 metal Substances 0.000 description 4
- 229910052751 metal Inorganic materials 0.000 description 4
- 230000001105 regulatory effect Effects 0.000 description 4
- 238000002604 ultrasonography Methods 0.000 description 4
- 208000014674 injury Diseases 0.000 description 3
- 230000002147 killing effect Effects 0.000 description 3
- 231100000915 pathological change Toxicity 0.000 description 3
- 230000036285 pathological change Effects 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- 238000001723 curing Methods 0.000 description 2
- 238000013461 design Methods 0.000 description 2
- 238000004146 energy storage Methods 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 239000003302 ferromagnetic material Substances 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 230000010355 oscillation Effects 0.000 description 2
- 230000035515 penetration Effects 0.000 description 2
- 230000000007 visual effect Effects 0.000 description 2
- 206010002091 Anaesthesia Diseases 0.000 description 1
- 208000017897 Carcinoma of esophagus Diseases 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 201000000297 Erysipelas Diseases 0.000 description 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 description 1
- 206010030155 Oesophageal carcinoma Diseases 0.000 description 1
- 230000037005 anaesthesia Effects 0.000 description 1
- 230000002491 angiogenic effect Effects 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 230000036770 blood supply Effects 0.000 description 1
- 239000003990 capacitor Substances 0.000 description 1
- 230000005779 cell damage Effects 0.000 description 1
- 230000030833 cell death Effects 0.000 description 1
- 208000037887 cell injury Diseases 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 239000000498 cooling water Substances 0.000 description 1
- 125000004122 cyclic group Chemical group 0.000 description 1
- 230000034994 death Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000005674 electromagnetic induction Effects 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 201000005619 esophageal carcinoma Diseases 0.000 description 1
- 230000001815 facial effect Effects 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 230000036737 immune function Effects 0.000 description 1
- 210000000987 immune system Anatomy 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 230000008676 import Effects 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 238000011337 individualized treatment Methods 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000010354 integration Effects 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 210000003712 lysosome Anatomy 0.000 description 1
- 230000001868 lysosomic effect Effects 0.000 description 1
- 230000005426 magnetic field effect Effects 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 238000011415 microwave curing Methods 0.000 description 1
- 210000003470 mitochondria Anatomy 0.000 description 1
- 230000005405 multipole Effects 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 230000005298 paramagnetic effect Effects 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 230000000649 photocoagulation Effects 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 239000004575 stone Substances 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 230000002194 synthesizing effect Effects 0.000 description 1
- 238000013519 translation Methods 0.000 description 1
- 210000001835 viscera Anatomy 0.000 description 1
Images
Landscapes
- Magnetic Treatment Devices (AREA)
- Thermotherapy And Cooling Therapy Devices (AREA)
- Electrotherapy Devices (AREA)
Abstract
The present invention discloses a new type medical apparatus, its control device and special-purpose nano material. Said medical apparatus includes contral device, special-purpose nano material and introduction device. Its special-purpose nano material is nano-level Fe3O4 particles with superparamagnetism, under the action of specific alternative magnetic field said nano material has controllable heating effect, said heating effect can heat tumor cell and tissue in focal region to make regional pathologic changed tissue necrotized and kill tumour cell, and said heating effect does not damage normal tissue, so that it can attain the goal of eliminating tumour and cancer by using "non-bleeding operation".
Description
Technical field:
The present invention relates to a kind of new type medical equipment and control device thereof and special-purpose nano material, this medical apparatus and instruments relates to the thermotherapy field.
Background technology:
Various malignant tumor are the common diseases that threaten broad masses of the people's life security, excision is to make patient obtain not have the unique method of cancer long term survival at present, but operative treatment is a handle double-edged sword, promptly in the excision cancerous protuberance, the strike of operation wound often makes patient can't spend anesthesia, operation is closed and death.Therefore the new type medical equipment of studying highly effective and safe and do not have (little) wound treats various malignant tumor and other surgical diseasess are important directions that medical circle is paid close attention to." depletion of blood surgical operation " is the tidemark that surgeon is pursued, but still can't realize at present.
Thermotherapy then is another effective way of the treatment tumor except that operation.Since ancient times, people have just understood with heat and have treated disease from practice.Ancient Times in China doctor once used " weary stone " and fire to treat disease, and had created the moxibustion of curing the disease with heat.And abroad, 1866 Busch (foreign name) delivered an example and be longer than facial malignant tumor, in the report of infecting erysipelas heating back tumor regression more than 40 ℃.The case of Rohdenbury (foreign name) report spontaneous regression of tumor in 1918 promptly has 72 routine tumor regression persons that severe infections companion hyperpyrexia was once arranged in 166 routine cancers or the history of using thermotherapy is arranged.These facts show that hyperpyrexia can play some effect to oncotherapy.
Modern medicine thinks, in the growth course, angiogenic growth deformity, structure disturbance, blood capillary pressurized also have blood sinus to form to tumor tissues in vivo.The blood supply of tumor tissues is than the obvious minimizing of normal structure, and blood flow rate is slow in the tumor, and blood flow is low, only is the 1%-10% of normal structure.This characteristic of tumor provides condition for " thermotherapy ".Tumor tissues causes that under high heat effect the instantaneity metabolic response causes its blood flow to reduce more, and heat is assembled and more with pH value reduction, oxygen lack and energy deficiency, thereby causes the damage of tumor cell.Hyperpyrexia can suppress DNA, RNA and proteinic the synthesizing of tumor cell, promptly suppresses the propagation of tumor cell.During hyperpyrexia, the many critical functions of tumor cell are impaired, destroy as lysosome, mitochondrion to cause cell death.Hyperpyrexia also can influence biomembranous state of tumor cell and function, and membrane permeability is increased, and low molecular protein is excessive, and the ATP enzyme disappears in the film, and the attack that this moment, tumor cell was difficult to resist lonizing radiation and chemotherapeutics is killed and wounded easily and kills.In addition, local thermotherapy also can stimulate body immune system, improves body's immunological function, plays the effect of restriction cancerous cell diffusion.
Based on above theory, developed in the prior art and several thermotherapy methods (claiming minimally-invasive treatment again), its pluses and minuses are as described below:
1) microwave curing thermotherapy: utilize the heat effect of microwave to make the tumor tissues coagulation necrosis, find that in recent years microwave also has the effect of enhancing human body immunity function.But because penetration is shallow, can only do shallow table heating, be used for superficial tumor more.
2) radio-frequency (RF) thermotherapeutic: this is a kind of high-temperature physics method of effective and safe.Under ultrasonic guidance, one pole or multipole probe percutaneous transhepatic puncture are positioned tumor tissues, the output radio frequency makes the downright bad curing of cancerous tissue, reaches therapeutic purposes.This therapy can cause the hot injury of tumor tissues periphery internal organs, causes serious consequence.
3) ultrasound wave focusing heat therapy: this method noinvasive is a kind of low-wound new technique that can locate and can produce high temperature (can reach more than 90 ℃) moment.Its penetration power is strong, can treat deep tumor.But owing to the restriction of ultrasound wave itself, can not penetrate the tissue of gassiness, can not penetrate skeleton, therefore be difficult to treat pulmonary carcinoma, the esophageal carcinoma of chest and the hepatocarcinoma that blocked by rib.Because ultrasound wave also must rely on water to mediate, the body surface of old friend's body tumor locus must contact with water, just can penetrate ultrasound wave, and patient posture is very limited.
Summary of the invention:
Purpose of the present invention is exactly for a kind of new type medical equipment and control device thereof and special-purpose nano material are provided, and thermotherapy is reached can the kill tumor cell, reduces the purpose to normal cell injury again as far as possible.
For achieving the above object, the present invention proposes a kind of new type medical equipment and control device and special-purpose nano material.
Described new type medical equipment is characterized in that comprising: control device, special-purpose nano material and gatherer; Described special-purpose nano material is the nanoscale Fe with superparamagnetism
3O
4Particle under specific action of alternating magnetic field, has controlled heating effect, and this heating effect can make the tumor cell in focus zone or tissue heat up, and causes regional pathological tissues necrosis.
The feature of described control device is: this control device can be launched the electromagnetic field that special-purpose nano material is heated up.
The feature of described special-purpose nano material is: this special-purpose nano material is the nanoscale Fe with superparamagnetism
3O
4Particle under specific action of alternating magnetic field, can be realized local accurately controlled heating effect, and this heating effect can make the tumor cell in focus zone or tissue heat up, and causes regional pathological tissues necrosis.
Owing to adopted above scheme, only need the specific complex nano material to be inserted cancerous protuberance focus part by import pipe, under the control device effect, make composite nano materials be fixed on focus local heating (such as: rise to 45-48 ℃), the interstitial laser photocoagulation cell is killed.And normal structure has good blood circulation fully to dispel the heat when being heated, thereby is subjected to less damage or injury-free, reaches the purpose of bloodless operation excision cancerous protuberance, the frontier of realizing " depletion of blood surgical operation ".
Description of drawings:
Fig. 1 is the structural representation of control device treatment platform of the present invention.
Fig. 2 is the structural representation of control device operating platform of the present invention
Fig. 3 is a gatherer sketch map of the present invention.
Fig. 4 is a gatherer injection needle sketch map of the present invention.
The specific embodiment:
Also the present invention is described in further detail in conjunction with the accompanying drawings below by specific embodiment.
Below new type medical equipment of the present invention is called visually " nano biological cutter ", claim " nanometer cutter " again, it comprises control device (as Fig. 1, Fig. 2), special-purpose nano material and gatherer (as Fig. 3,4); Described special-purpose nano material can heat up under the effect of electromagnetic field; Described gatherer is used for special-purpose nano material is inserted the focus part; Described control device is used to launch electromagnetic field to be made and inserts the partial special-purpose nano material of focus and heat up with the kill tumor histiocyte.
For this new type medical equipment is described in detail, introduce the action principle of nanometer cutter below earlier.
One,, when the magnetic flux that passes the closed-loop path changes, there is faradic current to produce in this loop according to Faraday law of electromagnetic induction.Faradic size is directly proportional with the variation rate of magnetic flux that passes this loop.
That is: I
Induction=K ΔΦ ... (1)
ΔΦ＝ΔBS ......(2)
ΔB?∝ΔIB ......(3)
ΔIB?∝f ......(4)
B∝NIB ......(5)
In the formula (1), I is sensed as the faradic current in the loop; K is a proportionality coefficient; ΔΦ is the variation rate of magnetic flux that passes in the closed-loop path.
In the formula (2), Δ B is for vertically passing the rate of change of the magnetic induction in the closed-loop path; S is the sectional area perpendicular to the closed-loop path of B.
In the formula (3), Δ IB is the rate of change of the electric current in the energization solenoid that produces magnetic field B." ∝ " pronounces and is proportional to
In the formula (4), f is the change frequency of IB.
In the formula (5), N is the number of turn on the energization solenoid unit length; IB is a current value for flowing through in the energization solenoid.
Can further learn to formula (5) by formula (1), when the magnetic flux that passes the closed-loop path changes, faradic size is directly proportional with size of current, change frequency in flowing through the energization solenoid that produces magnetic induction density B in the loop, is directly proportional with the number of turn on the energization solenoid unit length.
Know again from the physics that two, when electric current flow through the pure resistance circuit, electric energy can become a joule heat energy, and
P＝I
2R?......(6)
Q＝Pt ......(7)
In the formula (6), P is a power, and unit is watt; I is the electric current that flows through circuit, and unit is an ampere; R is the resistance that circuit had, and unit is ohm.
In the formula (7), Q is a heat, and unit is a joule; T is the time of effect, and unit is second.
Can inference, when excessive the changing of magnetic flux of the sheet metal of the ferromagnetic material by having certain sectional area, bulk, bar, can produce faradic current equally.Because the sheet metal of ferromagnetic material can equivalence be numerous closed-loop path, each loop all has the ring-type faradic current and produces.Utilize the integration method inference, must induce powerful cyclic currents in the metal object, be referred to as " eddy current " usually.Metal object is rapid heating up under the effect of " eddy current ".Its principle is an electric current when passing through an ohm circuit (loop), produces heat, and electric energy is converted into heat energy.
Three, nanometer Fe
3O
4Belong to super paramagnetic meterial.Under the high frequency magnetic field effect, powder particle produces the eddy current electrical phenomena, causes the heating up of material granule own.Inject this kind nano material preparation in the specific region, under the action of a magnetic field of high-frequency apparatus, the continuous heating up of preparation causes the corresponding intensification of cell or tissue on every side of its position, region.This temperature-rise period is accurately controlled, utilized the toleration difference of different cell tissues, can select " killing " cancerous tumor cell pointedly, cause the necrosis of focus zone and " excision " heat.This new technique can realize tumor cell or tissue necrosis, dwindle and be absorbed, patient's the state of an illness is effectively alleviated and treatment.
In view of the above, need an induction adjunction device in this new type medical equipment at least.
Four, the design principle of heater (especially its coil)
Core in the induction heater is a LC series resonant circuit part.Series resonant circuit is composed in series by inductance L, capacitor C.Learn that by Circuit theory series resonant circuit has a natural frequency f
0,
f
0＝1/(LC)
1/2
In the following formula, the inductance in the L series resonant circuit, i.e. the inductance value of the induction coil of induction heating apparatus, C is an electric capacity, both are energy-storage travelling wave tube.
The energy storage between L, C of oscillation energy in the series resonant circuit, release and can take turns stream translation, the frequency of conversion is exactly the output frequency of induction heater.Actual oscillation frequency f and f when circuit
0When equating, just be called circuit and be in the series resonance state, this moment is most effective, the energy maximum that obtains among the L, induction heating apparatus output maximum.When the heater output is maximum, is called induction coil and is in matching status.Therefore the design principle of load coil is that choosing of load coil parameter should make induction coil be in matching status.When being non-matching status, under the identical situation of device consumed power, efficient reduces, and output reduces, the heats variation, and heat time heating time is elongated.
Five, control device and the wherein configuration of eddy-current heating (treatment) device
See Fig. 1, the described control device of the embodiment of the invention is except that comprising controlled magnetic eddy current transmitter (1) (comprising above-mentioned induction heater is arranged), also comprise movable therapeutic bed (2), support (3) and starting switch (4), starting switch (4) is used to start controlled magnetic eddy current transmitter (1), described controlled magnetic eddy current transmitter (1) is positioned on the support (3), and movable therapeutic bed (2) can move in the electromagnetic field zone of controlled magnetic eddy current transmitter (1).
See Fig. 1,2, described control device also comprises temperature control system (5), vital sign and cardiac monitoring monitoring system (6), temperature control knob (7), cardiac monitoring control knob (8), frequency adjustment button (9) and current regulating switch (10); Vital sign and cardiac monitoring monitoring system (6) are used for when treatment patient being monitored in real time; Temperature control system (5) is subjected to temperature control knob (7) control, needed local heating amount when being set in treatment according to the result of monitoring or according to treatment plan; Frequency adjustment button (9) and current regulating switch (10) are used for regulating according to monitoring and result or treatment plan the frequency and the electric current of controlled magnetic eddy current transmitter (1).Here the temperature control system of saying (5), vital sign and cardiac monitoring monitoring system (6), temperature control knob (7) etc.
Most important part is exactly the configuration that comprises the induction heater in the controllable swirl transmitter 1 in the control device of the present invention, and focus characteristics and position that should basis be determined.To different focuses, should adopt the therapeutic apparatus of different configurations.
1, sonde-type
(1) the board-like probe of flat circle
(2) bar type hollow probe
(3) collection magnetic-type column type probe
2, camber arch cover formula probe
(1) hemispheric arch cover
(2) format arch cover
(3) corridor formula arch cover
3, the arm-type heating of C (treatment) device
Heat to treat device and be a key component in the nanometer cutter system, be referred to as " handle of a knife ".Six, other parts of system
Whole nanometer cutter therapy system also comprises following a few major part:
1, three-dimensional motion system
Three-dimensional motion system is used for the locus of adjustment of treatment device the high-intensity magnetic field center being aimed at focal zone to be treated, obtains the best effect that heats to treat.Three-dimensional motion system is subjected to the control of PLC Programmable Logic Controller.PLC is subjected to the control of one of host computer, control station, wireless intervention voice operated controls.
2, wireless access speech control system
The wireless access speech control system can be discerned specific voice command, realizes the adjusting to three-dimensional motion system.Voice control can embody science and technology more, and people-oriented, is the essence of mankind's service, person's more convenient to use operation.
3, intelligent low-temperature circulation cooling control system
Nanometer cutter induction heater is in heating process, and the electric current that flows through in the induction coil reaches about kiloampere, and the cooling problem of induction heater must be considered well.Intelligent low-temperature water cycle cooling control system is to be used for the temperature of accurate observing and controlling liquid coolant.This system has chilling temperature setting, detection, control, demonstration, overload alarm function.
4, image surveillance system
Image is the present position that is used for diagnosing out pathological tissues, the 2nd, be used for monitoring the situation of change of therapeutic process pathological tissues.Nanometer cutter induction heater is to utilize the toleration difference of different cell tissues to thermal change and temperature rise, can select " killing " cancerous tumor cell pointedly, causes focus lump zone downright bad " excision ".
Therefore in therapeutic process, should monitor the degree of focus heating by multiple means.The image surveillance system is that the variation of the image that reflects by focus comes the monitor treatment process, and guaranteeing the excision of pathological tissues, and health tissues is not subjected to or minimum suffering damage.Visual state as for concrete is determined by clinical practice.
5, focus temperature control system
Except monitoring the therapeutic process, also to monitor therapeutic effect by observing and controlling temperature means with visual means.The tolerable temperature definite value of supposing normal structure is T
Normally, the tolerable temperature of pathological tissues is a definite value T pathological changes, and T
Normally＞T
Pathological changes, actual heating-up temperature is variable T, the variations in temperature in the heating process of then should looking over one's shoulder makes T
Pathological changes＜T＜T
Normally, can effectively kill pathological tissues like this, tissue protects the health.The measurement and control of temperature means have following several
5.1 thermocouple temperature measuring equipment (table superficial part position) is hindered by Wicresoft
5.2 nonmetal temperature transducer checkout gear
5.3 the institute nano material draws it and is subjected to unique feature under the eddy-current heating state, and this feature is carried out observing and controlling, realizes noinvasive observing and controlling temperature.
6, patient's monitor system
Patient's monitor system is used in the therapeutic process, other data of monitored patient.As heart rate, blood pressure etc.
7, induction heating apparatus parameter investigating system
Induction heating apparatus has Several Parameters directly relevant with heats: the vibration output current.The vibration output frequency, heat time heating time.By observing and controlling, adjusting, can effectively control heating process to these parameters.And these regulating and controlling will realize closed loop control by the feedback of temperature, image.
8, data management system
Be used for the store patient person document, case history, treatment record etc.
9, print system
10, magnetic is assembled navigation system
After nanometer formulation was injected into the lesion, distributed model was uncertain.Utilize the superparamagnetism and the high-intensity magnetic field of this nanometer formulation to assemble navigation system, make the preparation in the lesion obtain assembling, improve coherent condition, to help heating.
11, the computer management system of therapy system
This system is the central control system of each system in the therapy system, implements each real-time monitoring.
Seven, nano material
The component of described special-purpose nano material can be expressed as WaYb, and wherein W is a ferrite nano particles, and mean diameter is 25nm, particle size range 0-60nm, apparent density 0.10-0.25g/cm
3, specific surface area 40-60m
2/ g, purity 99.9% (scope 99-100%), specific saturation magnetization 1477.0Am
2/ kg, in grasp coercivity 23.8KA/m, as the intensification main material; Y be 33% cardiografin as solvent, and can under X line perspective, carry out the location indication of nano material distribution focus.A, b be respectively W, Y, mass percent, value is respectively a: b=1-2.5: 97.5-99.
Because scantling is a nanometer scale, has superparamagnetism, can diffuse into cell interior again, and is stronger to the killing action of tumor cell.
Eight, gatherer
See Fig. 3, described gatherer comprises syringe needle (21), injection needle (22), manometer tube (23), diffusion handle (24) and control loop (25), described syringe needle (21) is installed on an end of injection needle (22), manometer tube (23) is installed on the other end of injection needle (22), control loop (25) and diffusion handle (24) are installed on injection needle (22) side, be respectively applied for the operator and hold the switch of taking with controlled pressure pipe (23), so that the special-purpose nano material in the injection needle (22) is injected into the focus part.Among Fig. 3, also comprise pressure regulator (26), spiral diffusion pin (being syringe needle) interface (27).The structure of its syringe needle is seen Fig. 4, wherein: input part (31), diffusion part (32), thrust portion (33).When pulling control loop (25), manometer tube (23) can be exerted pressure to injection needle (22), thereby the nano material in the pipe is injected into focal zone.(nano material that is diffused on a small quantity in the normal structure can excrete under homergy.)
Should be pointed out that gatherer should not be limited to this, any device that described nano material can be inserted focus is all available in principle, such as with interposing catheter, sight glass etc.
Nine, its therapeutic process is:
With gatherer special-purpose nano material (1-2.5% ferrite nano particles emulsion 1-5ML[decides according to tumor size and type) is inserted tumor locus, launch the electromagnetic wave of characteristic frequency, intensity then immediately with control device, and lasting 1-1.5 hour, make the ferrite nano particles heating up to 45-48 ℃, thereby tumor tissue cell can be killed.Before launching electromagnetic wave, can be in advance according to characteristics and size, nano material amount and the indexs such as concentration, electromagnetic frequency and intensity of tumor tissues, calculate the time (dosage) that good emission is continued, make the individualized treatment plan, launch according to treatment plan then.Normal structure has good blood circulation fully to dispel the heat when being heated, and the tumor tissues local temperature is when raising, because the cooling mechanism obstacle, can be higher than the 5%-10% of normal adjacent tissue.When high heat effect made tumor cell be in to kill and wound temperature (43 ℃), normal structure still was in lower temperature and is injury-free.
In therapeutic process, can also according to circumstances utilize temperature control system (5) to adjust required temperature value at any time.The foundation of its adjustment can be the result who is monitored by vital sign and cardiac monitoring monitoring system (6) (such as existing instruments such as electrocardiogram equipments).
Simultaneously, in order to reach better therapeutic effect, can be under radioscopy, according to the location indication of cardiografin as solvent, aiming at nano material has direction ground launching electromagnetic wave.
The therapeutic domain of nanometer cutter to a certain extent, the tumor classification that depends on the patient is the distance of body surface relatively in the focus zone.Generally speaking, lesions position is dark more, and the high-intensity magnetic field center of therapeutic apparatus just is difficult to more near area for treatment.Decay because the magnetic induction of therapeutic apparatus strengthens with distance, eddy current effect dies down, nanometer Fe
3O
4Heating functioin be difficult to more occur.In order to reach therapeutic effect, treatment time then must prolong.Simultaneously, tractor parameter must be adjusted accordingly.But, if adjusting range has surpassed the performance indications of equipment, then must consider to adopt ancillary method, for example can on therapeutic apparatus, install the collection magnetic device additional, carry out local magnetic field and strengthen.
The basic parameter of control device in the foregoing description (wherein mainly being HF induction heating apparatus) is listed below:
1, power
Nanometer Fe
3O
4Injection volume is generally 5-20g, is the fine dispersion state in 5-10ml liquid preparation kind.Heater is to nanometer Fe
3O
4The heating process kind, the heater main frame is to be in Light Condition basically, the power consumption of complete machine is extremely low.With regard to be applied at present zoopery or clinical with regard to, the maximum power output numerical value of this kind equipment of expert advice is 10KW.
2, frequency
According to inductive heating principle, certain at the heater output, under the certain condition of output current, the output frequency of equipment is high more, and heats is obvious more.Therefore the output frequency of heater should improve as far as possible, is beneficial to the heating of nano material.The output frequency of heater depends on selected electronic devices and components.Currently used electronic device, maximum operating frequency can reach 400KHZ.
3, electric current
The Current Regulation scope of equipment is generally 500-1000A, but usual range is in 500-800A.
4, voltage
Civil power 220V or 380V AC, 50HZ all can be used as the input voltage of equipment.
5, cooling water outlet temperature
Be advisable for common 15 ℃-25 ℃.
Claims (18)
1, a kind of new type medical equipment is characterized in that comprising: control device, special-purpose nano material and gatherer; Described special-purpose nano material is the nanoscale Fe with superparamagnetism
3O
4Particle under specific action of alternating magnetic field, has controlled heating effect, and this heating effect can make the tumor cell in focus zone or tissue heat up, and causes regional pathological tissues necrosis; Described gatherer is used for special-purpose nano material is inserted the focus part; Described control device is used to launch electromagnetic field to be made and inserts the partial special-purpose nano material of focus and heat up with the kill tumor histiocyte.
2, a kind of new type medical equipment as claimed in claim 1, it is characterized in that: described control device comprises controlled magnetic eddy current transmitter (1), movable therapeutic bed (2), support (3) and starting switch (4), described controlled magnetic eddy current transmitter (1) is positioned on the support (3), movable therapeutic bed (2) can move in the electromagnetic field zone of controlled magnetic eddy current transmitter (1), and starting switch (4) links to each other with controlled magnetic eddy current transmitter (1).
3, a kind of new type medical equipment as claimed in claim 2, it is characterized in that: described control device also comprises:
Three-dimensional motion system is used for the locus of control set for adjusting the high-intensity magnetic field center being aimed at focal zone to be treated, obtains the best effect that heats to treat; Described three-dimensional motion system is subjected to the control of Programmable Logic Controller, Programmable Logic Controller is subjected to the control of one of host computer, control station, wireless access voice operated controls, described wireless access speech control system can be discerned specific voice command, realizes the adjusting to three-dimensional motion system;
Intelligent low-temperature circulation cooling control system is used for the temperature of accurate observing and controlling liquid coolant, and this system has chilling temperature setting, detection, control, demonstration, overload alarm function;
The image surveillance system, be used for diagnosing out the present position of pathological tissues, and the situation of change that is used for monitoring the therapeutic process pathological tissues, it comes the monitor treatment process by the variation of the image that focus reflects, guaranteeing the excision of pathological tissues, and health tissues is not subjected to or minimum suffering damage;
The focus temperature control system is used for monitoring therapeutic effect by observing and controlling temperature means, and it comprises at least a with in the lower device: 1) the thermocouple temperature measuring equipment is hindered by Wicresoft; 2) nonmetal temperature transducer checkout gear; 3) temperature profile supervising device, it is by prior institute nano material, draws it and is subjected to unique feature under the eddy-current heating state, then this feature is carried out observing and controlling, realizes noinvasive observing and controlling temperature;
Patient's monitor system is used for vital sign and other data in the therapeutic process monitored patient, comprises heart rate, and pulse, blood pressure and electrocardio thereof change;
Induction heating apparatus parameter investigating system is used to monitor the directly parameter relevant with heats, comprising: vibration output current, vibration output frequency, heat time heating time, by observing and controlling, the adjusting to these parameters, effectively control heating process;
Data management system is used to store the patient data that comprises person document, case history, treatment record;
Magnetic is assembled navigation system, is used to make the preparation in the lesion to obtain assembling, and improves coherent condition, to help heating;
The computer management system of therapy system, the monitoring when implementing to each real-time operation.
4, a kind of new type medical equipment as claimed in claim 1 or 2, it is characterized in that: the component of described special-purpose nano material can be expressed as WaYb, and wherein W is a ferrite nano particles, and mean diameter is 25nm, particle size range 0-60nm, apparent density 0.10-0.25g/cm
3, specific surface area 40-60m
2/ g, purity 99%-100%, specific saturation magnetization 1477Am
2/ kg, in grasp coercivity 22.8-23.8KA/m, as the intensification main material; Y be 3% percentage by weight cardiografin as solvent, and can under X line perspective, carry out the location indication of nano material distribution focus; A, b are respectively the mass percent of W, Y, and value is respectively a: b=1-2.5: 97.5-99.
5, a kind of new type medical equipment as claimed in claim 1 or 2, it is characterized in that: described gatherer comprises syringe needle (21), injection needle (22), manometer tube (23), diffusion handle (24) and control loop (25), described syringe needle (21) is installed on an end of injection needle (22), manometer tube (23) is installed on the other end of injection needle (22), control loop (25) and diffusion handle (24) are installed on injection needle (22) side, be respectively applied for the operator and hold the switch of taking with controlled pressure pipe (23), so that the special-purpose nano material in the injection needle (22) is injected into the focus part.
6, a kind of control device that is used for new type medical equipment as claimed in claim 1 is characterized in that: this control device can be launched the electromagnetic field that special-purpose nano material is heated up.
7, new type medical equipment control device as claimed in claim 6, it is characterized in that: it comprises controlled magnetic eddy current transmitter (1), movable therapeutic bed (2), support (3) and starting switch (4), described controlled magnetic eddy current transmitter (1) is positioned on the support (3), movable therapeutic bed (2) can move in the electromagnetic field zone of controlled magnetic eddy current transmitter (1), and starting switch (4) links to each other with controlled magnetic eddy current transmitter (1).
8, new type medical equipment control device as claimed in claim 7 is characterized in that: also comprise three-dimensional motion system, be used for the locus of control set for adjusting the high-intensity magnetic field center being aimed at focal zone to be treated, obtain the best effect that heats to treat; Described three-dimensional motion system is subjected to the control of Programmable Logic Controller, Programmable Logic Controller is subjected to the control of one of host computer, control station, wireless access voice operated controls, described wireless access speech control system can be discerned specific voice command, realizes the adjusting to three-dimensional motion system.
9, new type medical equipment control device as claimed in claim 7 is characterized in that: also comprise cooling system, be used to cool off controlled magnetic eddy current transmitter (1); Also comprise intelligent low-temperature circulation cooling control system, be used for the temperature of liquid coolant in the accurate observing and controlling cooling system, this system has chilling temperature setting, detection, control, demonstration, overload alarm function.
10, new type medical equipment control device as claimed in claim 7, it is characterized in that: also comprise the image surveillance system, be used for diagnosing out the present position of pathological tissues, and the situation of change that is used for monitoring the therapeutic process pathological tissues, it comes the monitor treatment process by the variation of the image that focus reflects, guaranteeing the excision of pathological tissues, and health tissues is not subjected to or minimum suffering damage.
11, new type medical equipment control device as claimed in claim 7, it is characterized in that: also comprise the focus temperature control system, be used for monitoring therapeutic effect that it comprises at least a with in the lower device: 1) the thermocouple temperature measuring equipment is hindered by Wicresoft by observing and controlling temperature means; 2) nonmetal temperature transducer checkout gear; 3) temperature profile supervising device, it is by prior institute nano material, draws it and is subjected to unique feature under the eddy-current heating state, then this feature is carried out observing and controlling, realizes noinvasive observing and controlling temperature.
12, new type medical equipment control device as claimed in claim 7 is characterized in that: also comprise patient's monitor system, be used for vital sign and other data in the therapeutic process monitored patient, comprise heart rate, pulse, blood pressure and electrocardio thereof change.
13, new type medical equipment control device as claimed in claim 7, it is characterized in that: also comprise induction heating apparatus parameter investigating system, be used to monitor the directly parameter relevant with heats, comprise: vibration output current, vibration output frequency, heat time heating time, by observing and controlling, adjusting, effectively control heating process to these parameters.
14, new type medical equipment control device as claimed in claim 7 is characterized in that: also comprise data management system, be used to store the patient data that comprises person document, case history, treatment record.
15, new type medical equipment control device as claimed in claim 7 is characterized in that: also comprise magnetic gathering navigation system, be used to make the preparation in the lesion to obtain assembling, improve coherent condition, to help heating.
16, new type medical equipment control device as claimed in claim 7 is characterized in that: also comprise the computer management system of therapy system, the monitoring when implementing each real-time operation.
17, a kind of special-purpose nano material that is used for new type medical equipment as claimed in claim 1 is characterized in that: this special-purpose nano material is the nanoscale Fe with superparamagnetism
3O
4Particle under specific action of alternating magnetic field, can be realized local accurately controlled heating effect, and this heating effect can make the tumor cell in focus zone or tissue heat up, and causes regional pathological tissues necrosis.
18, new type medical equipment special-purpose nano material as claimed in claim 17, it is characterized in that: the component of described special-purpose nano material can be expressed as WaYb, and wherein W is a ferrite nano particles, and mean diameter is 25nm, particle size range 0-60nm, apparent density 0.10-0.25g/cm
3, specific surface area 40-60m
2/ g, purity 99%-100%, specific saturation magnetization 1477Am
2/ kg, in grasp coercivity 23.8KA/m, as the intensification main material; Y be 3% percentage by weight cardiografin as solvent, and can under X line perspective, carry out the location indication of nano material distribution focus; A, b are respectively the mass percent of W, Y, and value is respectively a: b=1-2.5: 97.5-99.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 02115249 CN1380044A (en) | 2002-05-15 | 2002-05-15 | New type medical equipment, its control device and special-purpose nano material |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 02115249 CN1380044A (en) | 2002-05-15 | 2002-05-15 | New type medical equipment, its control device and special-purpose nano material |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1380044A true CN1380044A (en) | 2002-11-20 |
Family
ID=4743540
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 02115249 Pending CN1380044A (en) | 2002-05-15 | 2002-05-15 | New type medical equipment, its control device and special-purpose nano material |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1380044A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100372908C (en) * | 2005-07-15 | 2008-03-05 | 东南大学 | Preparation method of nano heating agent for tumor magnetic hyperthermia |
| CN102814004A (en) * | 2012-09-07 | 2012-12-12 | 北京大学 | Gyromagnet treatment system based on magnetic nanoparticles |
| WO2021208212A1 (en) * | 2020-04-13 | 2021-10-21 | 孙志强 | Nuclear magnetic cell therapy device |
-
2002
- 2002-05-15 CN CN 02115249 patent/CN1380044A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100372908C (en) * | 2005-07-15 | 2008-03-05 | 东南大学 | Preparation method of nano heating agent for tumor magnetic hyperthermia |
| CN102814004A (en) * | 2012-09-07 | 2012-12-12 | 北京大学 | Gyromagnet treatment system based on magnetic nanoparticles |
| WO2021208212A1 (en) * | 2020-04-13 | 2021-10-21 | 孙志强 | Nuclear magnetic cell therapy device |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Guy et al. | Therapeutic applications of electromagnetic power | |
| KR102186353B1 (en) | Fine spatiotemporal control of thermolysis and lipolysis using nir light | |
| KR20140074909A (en) | Apparatus for the generation of an energy field for the treatment of cancer in body cavities and parts that are cavity-like | |
| CN110652656A (en) | Tumor Magnetic Induction Hyperthermia System | |
| KR20170115951A (en) | Device for Alternating Current Magnetic Field-induced Hyperthermia | |
| KR20030087632A (en) | Method of breaking cancer cell tissue by microelectromagnetic radiation and microelectromagnetic radiator | |
| CN101803948A (en) | Reverse temperature control combined probe type tumor thermal-therapeutic apparatus | |
| CN212038613U (en) | Magnetic induction thermotherapy temperature control device | |
| US11006998B2 (en) | Systems, methods, and media for wireless radio frequency lesioning | |
| CN1380044A (en) | New type medical equipment, its control device and special-purpose nano material | |
| CN105726119A (en) | Liquid metal bath pool type electrode electrotherapy device | |
| CN207694078U (en) | A kind of intelligent temperature control pulse heating acupuncture treating device | |
| CN105435371A (en) | 8-shaped coil transcranial magnetic stimulation system based on magnetic resonant coupling principle | |
| WO2007070725A2 (en) | Device producing and use of microwave energy for thermotherapy | |
| CN108578893A (en) | A kind of magnetic hysteresis thermotherapy set of endo-luminal ultrasound positioning | |
| CN101234232A (en) | Guided multi-alternating magnetic field focusing magnetothermal therapy machine | |
| CN212038614U (en) | Tumor magnetic induction thermotherapy system | |
| CN206543331U (en) | A kind of far IR curing instrument for automatically adjusting temperature | |
| US12220163B2 (en) | Wirelessly powered tissue ablation device | |
| CN201719369U (en) | Reverse temperature control combined probe-type tumor hyperthermia instrument | |
| Takook | Optimizing Microwave Hyperthermia Antenna Systems | |
| CN209405498U (en) | A device for magnetic induction hyperthermia in animals | |
| JP2005253813A (en) | Mri treatment system | |
| US20230158319A1 (en) | System for treating unwanted tissue | |
| WO2001032091A2 (en) | Non-invasive removal of fatty tissue by controlled application of heat |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| AD01 | Patent right deemed abandoned | ||
| C20 | Patent right or utility model deemed to be abandoned or is abandoned |