CN1369289A - Chinese medicine for treating cardiovascular and cerebrovascular diseases and its preparing process - Google Patents
Chinese medicine for treating cardiovascular and cerebrovascular diseases and its preparing process Download PDFInfo
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- CN1369289A CN1369289A CN 01129112 CN01129112A CN1369289A CN 1369289 A CN1369289 A CN 1369289A CN 01129112 CN01129112 CN 01129112 CN 01129112 A CN01129112 A CN 01129112A CN 1369289 A CN1369289 A CN 1369289A
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- radix salviae
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- 230000002526 effect on cardiovascular system Effects 0.000 title claims abstract description 18
- 208000026106 cerebrovascular disease Diseases 0.000 title claims abstract description 16
- 208000024172 Cardiovascular disease Diseases 0.000 title claims abstract description 15
- 238000000034 method Methods 0.000 title claims abstract description 11
- 230000008569 process Effects 0.000 title abstract description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 26
- 241000218628 Ginkgo Species 0.000 claims description 26
- 235000011201 Ginkgo Nutrition 0.000 claims description 26
- 235000008100 Ginkgo biloba Nutrition 0.000 claims description 26
- 239000000284 extract Substances 0.000 claims description 24
- 238000002360 preparation method Methods 0.000 claims description 20
- MOLPUWBMSBJXER-YDGSQGCISA-N bilobalide Chemical compound O([C@H]1OC2=O)C(=O)[C@H](O)[C@@]11[C@@](C(C)(C)C)(O)C[C@H]3[C@@]21CC(=O)O3 MOLPUWBMSBJXER-YDGSQGCISA-N 0.000 claims description 14
- 239000009636 Huang Qi Substances 0.000 claims description 12
- 239000000203 mixture Substances 0.000 claims description 11
- 239000004480 active ingredient Substances 0.000 claims description 9
- 210000000582 semen Anatomy 0.000 claims description 9
- 229930189533 tanshinol Natural products 0.000 claims description 8
- 239000000843 powder Substances 0.000 claims description 7
- AIGAZQPHXLWMOJ-UHFFFAOYSA-N Tanshinone I Chemical compound C1=CC2=C(C)C=CC=C2C(C(=O)C2=O)=C1C1=C2C(C)=CO1 AIGAZQPHXLWMOJ-UHFFFAOYSA-N 0.000 claims description 6
- 241000545442 Radix Species 0.000 claims description 5
- 238000004519 manufacturing process Methods 0.000 claims description 5
- 238000010992 reflux Methods 0.000 claims description 5
- 241000180649 Panax notoginseng Species 0.000 claims description 4
- 235000003143 Panax notoginseng Nutrition 0.000 claims description 4
- 244000018633 Prunus armeniaca Species 0.000 claims description 4
- 235000009827 Prunus armeniaca Nutrition 0.000 claims description 4
- 239000012141 concentrate Substances 0.000 claims description 4
- 238000001914 filtration Methods 0.000 claims description 4
- 238000010438 heat treatment Methods 0.000 claims description 4
- 150000002576 ketones Chemical class 0.000 claims description 4
- 239000007788 liquid Substances 0.000 claims description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 4
- 241000208340 Araliaceae Species 0.000 claims description 3
- SMDOOINVMJSDPS-UHFFFAOYSA-N Astragaloside Natural products C1=C(O)C(OC)=CC(C2=C(C(=O)C3=C(O)C=C(O)C=C3O2)OC2C(C(OC3C(C(O)C(O)C(CO)O3)O)C(O)C(CO)O2)O)=C1 SMDOOINVMJSDPS-UHFFFAOYSA-N 0.000 claims description 3
- SQGLUEWZRKIEGS-UHFFFAOYSA-N Ginkgetin Natural products C1=CC(OC)=CC=C1C1=CC(=O)C2=C(O)C=C(OC)C(C=3C(=CC=C(C=3)C=3OC4=CC(O)=CC(O)=C4C(=O)C=3)O)=C2O1 SQGLUEWZRKIEGS-UHFFFAOYSA-N 0.000 claims description 3
- 229930045534 Me ester-Cyclohexaneundecanoic acid Natural products 0.000 claims description 3
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 claims description 3
- 235000003140 Panax quinquefolius Nutrition 0.000 claims description 3
- 229930183118 Tanshinone Natural products 0.000 claims description 3
- QMNWISYXSJWHRY-XWJCTJPOSA-N astragaloside Chemical compound O1[C@H](C(C)(O)C)CC[C@]1(C)[C@@H]1[C@@]2(C)CC[C@]34C[C@]4(CC[C@H](O[C@H]4[C@@H]([C@@H](O)[C@H](O)CO4)O)C4(C)C)C4[C@@H](O[C@H]4[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O4)O)CC3[C@]2(C)C[C@@H]1O QMNWISYXSJWHRY-XWJCTJPOSA-N 0.000 claims description 3
- AIFCFBUSLAEIBR-UHFFFAOYSA-N ginkgetin Chemical compound C=1C(OC)=CC(O)=C(C(C=2)=O)C=1OC=2C(C=1)=CC=C(OC)C=1C1=C(O)C=C(O)C(C(C=2)=O)=C1OC=2C1=CC=C(O)C=C1 AIFCFBUSLAEIBR-UHFFFAOYSA-N 0.000 claims description 3
- 235000008434 ginseng Nutrition 0.000 claims description 3
- 239000006187 pill Substances 0.000 claims description 3
- 239000011347 resin Substances 0.000 claims description 3
- 229920005989 resin Polymers 0.000 claims description 3
- 239000007901 soft capsule Substances 0.000 claims description 3
- 208000024827 Alzheimer disease Diseases 0.000 abstract description 3
- 206010002383 Angina Pectoris Diseases 0.000 abstract description 3
- 208000029078 coronary artery disease Diseases 0.000 abstract description 3
- 244000194101 Ginkgo biloba Species 0.000 abstract 1
- 240000007164 Salvia officinalis Species 0.000 abstract 1
- 206010039966 Senile dementia Diseases 0.000 abstract 1
- 229940107666 astragalus root Drugs 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 235000005412 red sage Nutrition 0.000 abstract 1
- 230000017531 blood circulation Effects 0.000 description 8
- 230000000694 effects Effects 0.000 description 5
- 239000000796 flavoring agent Substances 0.000 description 5
- 235000019634 flavors Nutrition 0.000 description 5
- 239000012567 medical material Substances 0.000 description 5
- 201000006474 Brain Ischemia Diseases 0.000 description 4
- 206010008120 Cerebral ischaemia Diseases 0.000 description 4
- 239000008280 blood Substances 0.000 description 4
- 210000004369 blood Anatomy 0.000 description 4
- 206010008118 cerebral infarction Diseases 0.000 description 4
- 229940079593 drug Drugs 0.000 description 4
- 230000002107 myocardial effect Effects 0.000 description 4
- 230000001737 promoting effect Effects 0.000 description 4
- 230000009471 action Effects 0.000 description 3
- 230000000144 pharmacologic effect Effects 0.000 description 3
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- 206010002660 Anoxia Diseases 0.000 description 2
- 206010003210 Arteriosclerosis Diseases 0.000 description 2
- 206010048962 Brain oedema Diseases 0.000 description 2
- 206010008132 Cerebral thrombosis Diseases 0.000 description 2
- 206010021143 Hypoxia Diseases 0.000 description 2
- 206010061216 Infarction Diseases 0.000 description 2
- 201000001429 Intracranial Thrombosis Diseases 0.000 description 2
- 208000007536 Thrombosis Diseases 0.000 description 2
- 230000002785 anti-thrombosis Effects 0.000 description 2
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- 230000008499 blood brain barrier function Effects 0.000 description 2
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- 239000002775 capsule Substances 0.000 description 2
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- 230000003727 cerebral blood flow Effects 0.000 description 2
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- 230000036284 oxygen consumption Effects 0.000 description 2
- 230000001681 protective effect Effects 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 241001061264 Astragalus Species 0.000 description 1
- 206010013786 Dry skin Diseases 0.000 description 1
- 235000006533 astragalus Nutrition 0.000 description 1
- 230000002490 cerebral effect Effects 0.000 description 1
- 238000002651 drug therapy Methods 0.000 description 1
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- 150000004676 glycans Chemical class 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 230000001077 hypotensive effect Effects 0.000 description 1
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- 210000004233 talus Anatomy 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
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- Medicines Containing Plant Substances (AREA)
Abstract
A Chinese medicine for treating cardiovascular and cerebrovascular diseases, such as coronary heart diseases, stenocardia, senile dementia, etc. is prepared from 3 Chinese-medicinal materials: red sage root, gingko leaf and astragalus root through extracting, proportioning and dispensing. Its advantages are simple preparing process, and full use of active components.
Description
The present invention is a kind of Chinese medicine preparation for the treatment of cardiovascular and cerebrovascular disease and preparation method thereof, belongs to technical field of medicaments.
Cardiovascular and cerebrovascular disease is a kind of frequently-occurring disease, commonly encountered diseases, existing Drug therapy generally is to take independent Chinese medicine product, such as: the Radix Salviae Miltiorrhizae goods, Semen Ginkgo goods etc., because these medicines are generally the single preparation, so there is not the usefulness of Comprehensive Treatment, therapeutic effect is undesirable, can only alleviate suffering from symptom, there is not special obvious treatment effect, Radix Salviae Miltiorrhizae mainly contains for the pharmacological action of cardiovascular and cerebrovascular vessel: coronary blood flow increasing, accelerate the periphery microcirculation blood flow, and increase the open number of capillary bed, improve heart merit and dwindle infarction size, antithrombotic, effects such as anti-cardiac-cerebral ischemia and accent blood fat; The Radix Astragali mainly contains for the pharmacological action of cardiovascular and cerebrovascular vessel: increase coronary flow and myocardial oxygen consumption, improve cardiac function, strengthen the anti-virus ability of cardiac muscle, the metabolism of anti-anoxia ability and enhancing myocardial cell, arteriosclerosis, blood vessel dilating and hypotensive effect have protective effect for cerebral ischemia associated with hydrocephalus, blood brain barrier, the local wachte measurer of brain; Folium Ginkgo extract mainly contains for the pharmacological action of cardiovascular and cerebrovascular vessel: expansion of cerebral vascular, cerebral blood flow increasing amount, reduce vascular resistance, also reduce cardiac muscular tension-time index, improve hemorheology status, blood circulation promoting, suppress thrombosis, alleviate cerebral hypoxia ischemia and cerebral edema, medium etc. affects the nerves; The medicines that utilize this three flavor two in Chinese medicine flavor to produce the in the prior art use of having gone on the market, such as: heart Yuan capsule, NAOLUOTONG JIAONANG etc.; But through the retrieval in State Administration of Traditional Chinese Medicine China Chinese medicine documentation retrieval centre, " not finding by Folium Ginkgo, Radix Salviae Miltiorrhizae, the Radix Astragali three flavor medicines is that prescription is declared new drug or declared the bibliographical information of Chinese medicine health care product patent ".
The objective of the invention is to: a kind of Chinese medicine preparation for the treatment of cardiovascular and cerebrovascular disease and preparation method thereof is provided, this medicine is that Radix Salviae Miltiorrhizae, Folium Ginkgo, this three active ingredient of distinguishing the flavor of Chinese medicine of the Radix Astragali are become preparation according to certain prescription, ratio making after extracting, medicine combines this three flavors Chinese medicine separately for the function of people body-centered, cerebrovascular disease therapy, effect with blood circulation promoting and blood stasis dispelling, invigorating qi and dredging collateral can be treated cardiovascular and cerebrovascular diseases such as coronary heart disease, angina pectoris and alzheimer disease, cerebral thrombosis; The formulation method that is provided is simple, can not destroy active ingredient in the medical material, can utilize the medical material active ingredient fully, saves production cost.
The present invention constitutes like this: the Chinese medicine preparation of treatment cardiovascular and cerebrovascular disease is that 800-1400 is restrained Radix Salviae Miltiorrhizae, and 600-1200 restrains the Radix Astragali, extracts wherein active ingredient respectively after the processing of 600-1200 gram Folium Ginkgo process, is made into 1000 preparations; Say accurately: with 1200 gram Radix Salviae Miltiorrhizaes, the 1000 gram Radixs Astragali, 1000 gram Folium Ginkgos extract wherein active ingredient respectively after processing, be made into 1000 preparations; Be to improve therapeutic effect, can also be outside Radix Salviae Miltiorrhizae, the Radix Astragali, Folium Ginkgo extract, simultaneously or add a certain amount of Radix Ginseng, Radix Notoginseng respectively; The manufacture method of the Chinese medicine preparation of this treatment cardiovascular and cerebrovascular disease, be to use the alcohol heating reflux of 95-100% to extract the Radix Salviae Miltiorrhizae of aforementioned proportion, concentrate the tanshinol extract, medicinal residues are kept somewhere standby, get existing alcohol extraction----the resin method technology of Folium Ginkgo utilization and extract the Semen Ginkgo extrac (GBE) that obtains compositions such as apricot yellow ketone of argentiferous and bilobalide, adding decocting in water after Radix Salviae Miltiorrhizae decoction dregs and the Radix Astragali merging, ethanol will be added behind the liquid filtering, transfer to and contain ethanol 60-70%, technical finesse obtains extractum routinely, at last the tanshinol extract that obtains, Semen Ginkgo extrac and extractum merge, mix homogeneously is made powder after the oven dry, incapsulate; The present invention also can utilize prior art to extract tanshinone from Radix Salviae Miltiorrhizae, extracts astragaloside from the Radix Astragali, extract ginkgetin and bilobalide from Folium Ginkgo, it is mixed into paste, be made into soft capsule or drop pill, make medicine preparation more perfect like this, improve its effective percentage, satisfy different patient demands.
Compared with prior art: medicine of the present invention has the function of blood circulation promoting and blood stasis dispelling, invigorating qi and dredging collateral, can treat cardiovascular and cerebrovascular diseases such as coronary heart disease, angina pectoris and alzheimer disease, cerebral thrombosis; The formulation method that is provided is simple, can not destroy active ingredient in the medical material, can utilize the medical material active ingredient fully, saves production cost; In product, make full use of prescription medical material effect separately, can coronary blood flow increasing, accelerate the periphery microcirculation blood flow, increase the open number of capillary bed, improve heart merit and dwindle infarction size, antithrombotic, anti-cardiac-cerebral ischemia and transfer blood fat; Increase myocardial oxygen consumption; improve cardiac function; strengthen the anti-virus ability of cardiac muscle, the metabolism of anti-anoxia ability and enhancing myocardial cell, arteriosclerosis, blood vessel dilating; for cerebral ischemia associated with hydrocephalus, blood brain barrier, the local wachte measurer of brain protective effect is arranged; the cerebral blood flow increasing amount reduces vascular resistance, also reduces cardiac muscular tension-time index; improve hemorheology status, blood circulation promoting, suppress thrombosis, alleviate cerebral hypoxia ischemia and cerebral edema, medium etc. affects the nerves.
Embodiments of the invention 1: the alcohol heating reflux of 1200 gram Radix Salviae Miltiorrhizaes with 95-100% extracted, concentrate the tanshinol extract, medicinal residues are kept somewhere standby, get 1000 gram Folium Ginkgo dryings, pulverize, use the alcohol reflux of 50-70% then, utilize prior art to extract the Semen Ginkgo extrac (GBE) that obtains compositions such as apricot yellow ketone of argentiferous and bilobalide, adding decocting in water after Radix Salviae Miltiorrhizae decoction dregs and the 1000 gram Radixs Astragali merging, ethanol will be added behind the liquid filtering, transfer to and contain ethanol 60-70%, technical finesse obtains extractum routinely, at last the tanshinol extract that obtains, Semen Ginkgo extrac and extractum merge, mix homogeneously, make powder after the oven dry, in 1000 capsules of packing into.
Embodiments of the invention 2: the alcohol heating reflux of 800 gram Radix Salviae Miltiorrhizaes with 95-100% extracted, concentrate the tanshinol extract, medicinal residues are kept somewhere standby, get existing alcohol extraction----the resin method technology of 1200 gram Folium Ginkgo utilizations and extract the Semen Ginkgo extrac (GBE) that obtains compositions such as apricot yellow ketone of argentiferous and bilobalide, adding decocting in water after Radix Salviae Miltiorrhizae decoction dregs and the 600 gram Radixs Astragali merging, ethanol will be added behind the liquid filtering, transfer to and contain ethanol 60-70%, carry out precipitate with ethanol, obtain extractum, at last the tanshinol extract that obtains, Semen Ginkgo extrac and extractum merge, mix homogeneously is made powder after the oven dry, incapsulate 1000.
Embodiments of the invention 3: get 1200 gram Radix Salviae Miltiorrhizaes, the 1000 gram Radixs Astragali, 1000 gram Folium Ginkgos utilize prior art to extract from Radix Salviae Miltiorrhizae, isolate tanshinone, extract astragalus polysaccharides and astragaloside from the Radix Astragali, extract ginkgetin and bilobalide from Folium Ginkgos, it is mixed into paste, is made into soft capsule or drop pill.
Embodiments of the invention 4: in embodiment 1,2 provided by the invention, add an amount of chippy Radix Notoginseng powder and Radix Notoginseng powder and Radix Ginseng powder's mixture respectively.Improve the effect of treatment like this, strengthen patient's body constitution.
Claims (5)
1, a kind of Chinese medicine preparation for the treatment of cardiovascular and cerebrovascular disease is characterized in that: 800-1400 is restrained Radix Salviae Miltiorrhizae, and 600-1200 restrains the Radix Astragali, and 600-1200 gram Folium Ginkgo extracts wherein active ingredient respectively after processing, be made into 1000 preparations.
2, according to the Chinese medicine preparation of the described this treatment cardiovascular and cerebrovascular disease of claim 1, it is characterized in that: with 1200 gram Radix Salviae Miltiorrhizaes, the 1000 gram Radixs Astragali, 1000 gram Folium Ginkgos extract wherein active ingredient respectively after processing, be made into 1000 preparations.
3, according to the Chinese medicine preparation of claim 1,2 described this treatment cardiovascular and cerebrovascular diseases, it is characterized in that: outside Radix Salviae Miltiorrhizae, the Radix Astragali, Folium Ginkgo extract, can also simultaneously or add a certain amount of Radix Ginseng, Radix Notoginseng respectively.
4, the manufacture method of the Chinese medicine preparation of treatment cardiovascular and cerebrovascular disease, it is characterized in that: the alcohol heating reflux of Radix Salviae Miltiorrhizae with 95-100% extracted, concentrate the tanshinol extract, medicinal residues are kept somewhere standby, get existing alcohol extraction----the resin method technology of Folium Ginkgo utilization and extract the Semen Ginkgo extrac (GBE) that obtains compositions such as apricot yellow ketone of argentiferous and bilobalide, adding decocting in water after Radix Salviae Miltiorrhizae decoction dregs and the Radix Astragali merging, ethanol will be added behind the liquid filtering, transfer to and contain ethanol 60-70%, technical finesse obtains extractum routinely, at last the tanshinol extract that obtains, Semen Ginkgo extrac and extractum merge, mix homogeneously is made powder after the oven dry, incapsulate.
5, according to the manufacture method of the Chinese medicine preparation of the described this treatment cardiovascular and cerebrovascular disease of claim 4, it is characterized in that: utilize prior art from Radix Salviae Miltiorrhizae, to extract tanshinone, from the Radix Astragali, extract astragaloside, from Folium Ginkgo, extract ginkgetin and bilobalide, it is mixed into paste, is made into soft capsule or drop pill.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01129112 CN1199664C (en) | 2001-11-23 | 2001-11-23 | Chinese medicine for treating cardiovascular and cerebrovascular diseases and its preparing process |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01129112 CN1199664C (en) | 2001-11-23 | 2001-11-23 | Chinese medicine for treating cardiovascular and cerebrovascular diseases and its preparing process |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1369289A true CN1369289A (en) | 2002-09-18 |
| CN1199664C CN1199664C (en) | 2005-05-04 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 01129112 Expired - Fee Related CN1199664C (en) | 2001-11-23 | 2001-11-23 | Chinese medicine for treating cardiovascular and cerebrovascular diseases and its preparing process |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1199664C (en) |
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004050107A1 (en) * | 2002-11-29 | 2004-06-17 | Yong Zhang | A drop pill of treating and preventing from cardio-cerebral diseases and the process of producing thereof |
| CN1305405C (en) * | 2004-12-09 | 2007-03-21 | 桂林莱茵生物制品有限公司 | Health food with subsidiary function of lowering blood sugar and lowering blood fat and its production process |
| CN103083400A (en) * | 2013-03-01 | 2013-05-08 | 云南郡筹制药有限公司 | Drug for treating cardiovascular disease |
| CN103316302A (en) * | 2013-07-08 | 2013-09-25 | 陈静静 | Chinese medicine formula for treating angina pectoris |
| CN105380996A (en) * | 2015-11-10 | 2016-03-09 | 石任兵 | Medicine substance with effects of promoting blood circulation and stopping bleeding, as well as prescription, preparation method and application thereof |
| CN105687492A (en) * | 2016-04-13 | 2016-06-22 | 陈文洪 | Traditional Chinese medicine preparation for treating cardiovascular and cerebrovascular diseases |
| CN107759654A (en) * | 2017-10-27 | 2018-03-06 | 中国科学院成都生物研究所 | The application of Radix Astragali thuja acid and its derivative in antithrombotic reagent is prepared |
| CN108066645A (en) * | 2017-12-14 | 2018-05-25 | 芜湖市诺康生物科技有限公司 | A kind of preparation method of ginkgo leaf capsule of red sage root |
| CN115089655A (en) * | 2022-05-12 | 2022-09-23 | 北京宜生堂医药科技研究有限公司 | Traditional Chinese medicine composition for treating Alzheimer's disease, extract, preparation method and application |
-
2001
- 2001-11-23 CN CN 01129112 patent/CN1199664C/en not_active Expired - Fee Related
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004050107A1 (en) * | 2002-11-29 | 2004-06-17 | Yong Zhang | A drop pill of treating and preventing from cardio-cerebral diseases and the process of producing thereof |
| CN1305405C (en) * | 2004-12-09 | 2007-03-21 | 桂林莱茵生物制品有限公司 | Health food with subsidiary function of lowering blood sugar and lowering blood fat and its production process |
| CN103083400A (en) * | 2013-03-01 | 2013-05-08 | 云南郡筹制药有限公司 | Drug for treating cardiovascular disease |
| CN103316302A (en) * | 2013-07-08 | 2013-09-25 | 陈静静 | Chinese medicine formula for treating angina pectoris |
| CN105380996A (en) * | 2015-11-10 | 2016-03-09 | 石任兵 | Medicine substance with effects of promoting blood circulation and stopping bleeding, as well as prescription, preparation method and application thereof |
| CN105687492A (en) * | 2016-04-13 | 2016-06-22 | 陈文洪 | Traditional Chinese medicine preparation for treating cardiovascular and cerebrovascular diseases |
| CN107759654A (en) * | 2017-10-27 | 2018-03-06 | 中国科学院成都生物研究所 | The application of Radix Astragali thuja acid and its derivative in antithrombotic reagent is prepared |
| CN108066645A (en) * | 2017-12-14 | 2018-05-25 | 芜湖市诺康生物科技有限公司 | A kind of preparation method of ginkgo leaf capsule of red sage root |
| CN115089655A (en) * | 2022-05-12 | 2022-09-23 | 北京宜生堂医药科技研究有限公司 | Traditional Chinese medicine composition for treating Alzheimer's disease, extract, preparation method and application |
| CN115089655B (en) * | 2022-05-12 | 2023-09-08 | 北京宜生堂医药科技研究有限公司 | Traditional Chinese medicine composition for treating Alzheimer's disease, extract, preparation method and application |
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| Publication number | Publication date |
|---|---|
| CN1199664C (en) | 2005-05-04 |
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