CN1368194A - Nano medicine 'Compound Zhenzhu Anchuan' and its praparing process - Google Patents
Nano medicine 'Compound Zhenzhu Anchuan' and its praparing process Download PDFInfo
- Publication number
- CN1368194A CN1368194A CN 01102526 CN01102526A CN1368194A CN 1368194 A CN1368194 A CN 1368194A CN 01102526 CN01102526 CN 01102526 CN 01102526 A CN01102526 A CN 01102526A CN 1368194 A CN1368194 A CN 1368194A
- Authority
- CN
- China
- Prior art keywords
- nanometer
- nano
- skin sore
- powder
- parts
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000003814 drug Substances 0.000 title claims abstract description 43
- 150000001875 compounds Chemical class 0.000 title claims abstract description 15
- 238000000034 method Methods 0.000 title claims description 12
- 239000000843 powder Substances 0.000 claims abstract description 27
- 239000000463 material Substances 0.000 claims abstract description 20
- 238000001694 spray drying Methods 0.000 claims abstract description 5
- 229940079593 drug Drugs 0.000 claims description 19
- 238000002360 preparation method Methods 0.000 claims description 19
- 235000005956 Cosmos caudatus Nutrition 0.000 claims description 12
- 244000293323 Cosmos caudatus Species 0.000 claims description 12
- 241000282817 Bovidae Species 0.000 claims description 8
- 241000209020 Cornus Species 0.000 claims description 8
- 239000002775 capsule Substances 0.000 claims description 7
- 239000008187 granular material Substances 0.000 claims description 6
- 238000002347 injection Methods 0.000 claims description 6
- 239000007924 injection Substances 0.000 claims description 6
- 239000006187 pill Substances 0.000 claims description 6
- 239000002994 raw material Substances 0.000 claims description 5
- 239000002904 solvent Substances 0.000 claims description 5
- 241000212941 Glehnia Species 0.000 claims description 4
- 241000207929 Scutellaria Species 0.000 claims description 4
- 239000012141 concentrate Substances 0.000 claims description 4
- 235000008504 concentrate Nutrition 0.000 claims description 4
- 238000001035 drying Methods 0.000 claims description 4
- 238000000605 extraction Methods 0.000 claims description 4
- 230000008676 import Effects 0.000 claims description 4
- 238000002156 mixing Methods 0.000 claims description 4
- 239000000443 aerosol Substances 0.000 claims description 3
- 239000006196 drop Substances 0.000 claims description 3
- 239000000796 flavoring agent Substances 0.000 claims description 3
- 235000019634 flavors Nutrition 0.000 claims description 3
- 239000012528 membrane Substances 0.000 claims description 3
- 239000003094 microcapsule Substances 0.000 claims description 3
- 239000002674 ointment Substances 0.000 claims description 3
- 229940100688 oral solution Drugs 0.000 claims description 3
- 239000000829 suppository Substances 0.000 claims description 3
- 239000006188 syrup Substances 0.000 claims description 3
- 235000020357 syrup Nutrition 0.000 claims description 3
- 239000003826 tablet Substances 0.000 claims description 2
- 239000003390 Chinese drug Substances 0.000 claims 2
- 230000000694 effects Effects 0.000 abstract description 9
- 208000002874 Acne Vulgaris Diseases 0.000 abstract 1
- 241000736199 Paeonia Species 0.000 abstract 1
- 235000006484 Paeonia officinalis Nutrition 0.000 abstract 1
- 206010000496 acne Diseases 0.000 abstract 1
- 210000003056 antler Anatomy 0.000 abstract 1
- 201000004624 Dermatitis Diseases 0.000 description 4
- 239000003795 chemical substances by application Substances 0.000 description 4
- 239000002671 adjuvant Substances 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 208000010668 atopic eczema Diseases 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 230000017531 blood circulation Effects 0.000 description 2
- 238000004140 cleaning Methods 0.000 description 2
- 239000013078 crystal Substances 0.000 description 2
- 230000003203 everyday effect Effects 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 239000002086 nanomaterial Substances 0.000 description 2
- 239000011858 nanopowder Substances 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 239000000825 pharmaceutical preparation Substances 0.000 description 2
- 230000000144 pharmacologic effect Effects 0.000 description 2
- 231100000614 poison Toxicity 0.000 description 2
- 239000007962 solid dispersion Substances 0.000 description 2
- 239000003440 toxic substance Substances 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 229940126678 chinese medicines Drugs 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 230000002500 effect on skin Effects 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Abstract
A nanometre (0.1-200 nm) medicine "Compound Pearl" for treating acne is prepared from the nanometre powders of 7 Chinese medicinal materials including nacreous layer powder, pilose antler, red peony root, etc. through proportioning, microwave extracting, pressure reduction concentrating and supersonic-jet spray drying. Its grain fineness reaches 1200-1500 meshes and grain diameters are 0.1-200 nm. Its advantages are high biological utilization rate and high curative effect.
Description
The present invention relates to the nano compound Margarita skin sore preparation medicine that a kind of heat-clearing and toxic substances removing, removing heat from blood are promoted blood circulation, the invention still further relates to the method for this medication preparation.
FUFANG ZHENZHU ANCHUANG PIAN is a kind of classical Chinese patent medicine, mainly contains the effect such as promote blood circulation of heat-clearing and toxic substances removing, removing heat from blood, is used to eliminate young face skin sore and skin eczema, dermatitis.But traditional FUFANG ZHENZHU ANCHUANG PIAN disintegrate is slower, absorbs not exclusively, and bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully the nano compound Margarita skin sore preparation medicine of increase evident in efficacy.
Another object of the present invention provides the preparation method of this nano compound Margarita skin sore preparation medicine.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
Nanometer skin sore dry extract 80-180 part nano-pearl layer powder 1-6 part nano antelope horn powder 1-5 part
Nanometer Pulvis Cornus Bubali Concentratus 6-18 part nanometer Radix Glehniae 35-80 part nanometer Radix Paeoniae Rubra 35-80 part
Nanometer Radix Scutellariae 35-80 part
The formula optimization weight proportion scope of medicine of the present invention is:
Nanometer skin sore dry extract 100-150 part nano-pearl layer powder 2-5 part nano antelope horn powder 1-3 part
Nanometer Pulvis Cornus Bubali Concentratus 8-15 part nanometer Radix Glehniae 40-60 part nanometer Radix Paeoniae Rubra 40-60 part
Nanometer Radix Scutellariae 40-60 part
The optimum weight proportioning of medicine of the present invention is:
1 part in 3 parts of nano antelope horn powder of 120 parts of nano-pearl layers of nanometer skin sore dry extract powder
50 parts of 50 parts of nanometer Radix Paeoniae Rubra of 10 parts of nanometer Radix Glehniaes of nanometer Pulvis Cornus Bubali Concentratus
50 parts of nanometer Radix Scutellariaes
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material be since special construction----the material grains size of nano material less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15--50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, be processed into the common Chinese decoction pieces according to process of preparing Chinese medicine of Chinese Pharmacopoeia version in 2000.
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃--and 60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, promptly make the nanometer prepared slices of Chinese crude drugs with hypersonic velocity instantaneous jet drying.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, get Compound Zhenzhu skin sore preparation nano powder with hypersonic velocity instantaneous jet drying;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
The pharmacological effect that above-mentioned two kinds of methods are made nano compound Margarita skin sore preparation medicine is identical.
A kind of important feature of the present invention is: the made drug material of the present invention has reached nanoscale, common FUFANG ZHENZHU ANCHUANG PIAN preparation material is micron or the above particle diameter of millimeter, can only cross the 80-120 mesh sieve, the drug material that the present invention is made, particle diameter is at 0.1--200nm, the overwhelming majority can be crossed the 1200--1500 mesh sieve less than 100nm.
Another important feature of the present invention is: solid preparation of the present invention disintegrate rapidly, and solid dispersion is good in water, absorb fully, the bioavailability height, the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also created the novel form that pill, powder, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution of nano compound Margarita skin sore preparation medicine etc. had no precedent in the past.
Pharmaceutical preparation of the present invention can be used for treatment of conditions such as young face skin sore and skin eczema, dermatitis, and clinical efficacy significantly is better than traditional FUFANG ZHENZHU ANCHUANG PIAN.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment 1:
Prepare nano raw material by preceding method:
1 part in 3 parts of nano antelope horn powder of 120 parts of nano-pearl layers of nanometer skin sore dry extract powder
50 parts of 50 parts of nanometer Radix Paeoniae Rubra of 10 parts of nanometer Radix Glehniaes of nanometer Pulvis Cornus Bubali Concentratus
50 parts of nanometer Radix Scutellariaes
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, do not granulate, directly divide encapsulated with the fully-automatic capsule racking machine, make capsule, every capsules content of dispersion is the 0.1--0.6 gram, and the patient takes the 1-5 grain at every turn, and take 1-4 every day.
Embodiment 2:
Prepare nano raw material by preceding method:
1 part in 3 parts of nano antelope horn powder of 120 parts of nano-pearl layers of nanometer skin sore dry extract powder
50 parts of 50 parts of nanometer Radix Paeoniae Rubra of 10 parts of nanometer Radix Glehniaes of nanometer Pulvis Cornus Bubali Concentratus
50 parts of nanometer Radix Scutellariaes
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or the described mixed of powder good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia powder needle injection standard, do not add any adjuvant, make nano compound Margarita skin sore powder needle injection, every injection content is the 5-20 milligram, each consumption is that 1-2 props up, and use 1-3 every day.
Claims (6)
1, a kind of nano compound Margarita skin sore preparation medicine is characterized in that it is the medicament that the nano raw material of following weight proportioning is made:
Nanometer skin sore dry extract 80-180 part nano-pearl layer powder 1-6 part nano antelope horn powder 1-5 part
Nanometer Pulvis Cornus Bubali Concentratus 6-18 part nanometer Radix Glehniae 35-80 part nanometer Radix Paeoniae Rubra 35-80 part
Nanometer Radix Scutellariae 35-80 part
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
2, nano compound Margarita skin sore preparation medicine according to claim 1, wherein the weight proportion of each nano raw material is:
Nanometer skin sore dry extract 100-150 part nano-pearl layer powder 2-5 part nano antelope horn powder 1-3 part
Nanometer Pulvis Cornus Bubali Concentratus 8-15 part nanometer Radix Glehniae 40-60 part nanometer Radix Paeoniae Rubra 40-60 part
Nanometer Radix Scutellariae 40-60 part
3, nano compound Margarita skin sore preparation medicine according to claim 1, wherein the weight proportion of each nano raw material is:
1 part in 3 parts of nano antelope horn powder of 120 parts of nano-pearl layers of nanometer skin sore dry extract powder
50 parts of 50 parts of nanometer Radix Paeoniae Rubra of 10 parts of nanometer Radix Glehniaes of nanometer Pulvis Cornus Bubali Concentratus
50 parts of nanometer Radix Scutellariaes
4, according to claim 1 or 2 or 3 described nano compound Margarita skin sore preparation medicines, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
5,, it is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs according to the pharmaceutical methods of claim 1 or 2 or 3 described nano compound Margarita skin sore preparation medicines; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
6, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01102526 CN1368194A (en) | 2001-02-01 | 2001-02-01 | Nano medicine 'Compound Zhenzhu Anchuan' and its praparing process |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01102526 CN1368194A (en) | 2001-02-01 | 2001-02-01 | Nano medicine 'Compound Zhenzhu Anchuan' and its praparing process |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1368194A true CN1368194A (en) | 2002-09-11 |
Family
ID=4652787
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 01102526 Pending CN1368194A (en) | 2001-02-01 | 2001-02-01 | Nano medicine 'Compound Zhenzhu Anchuan' and its praparing process |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1368194A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100404047C (en) * | 2005-07-22 | 2008-07-23 | 张友生 | Medicinal composition for treating acne and eczema and its preparing method |
-
2001
- 2001-02-01 CN CN 01102526 patent/CN1368194A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100404047C (en) * | 2005-07-22 | 2008-07-23 | 张友生 | Medicinal composition for treating acne and eczema and its preparing method |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN1364538A (en) | Nano bronchitis treating medicine and its preparing method | |
| CN1368194A (en) | Nano medicine 'Compound Zhenzhu Anchuan' and its praparing process | |
| CN1368066A (en) | Nano ginseng-pearl medicine and its preparing process | |
| CN1365676A (en) | Nano medicine 'Compound berberine' and its preparing process | |
| CN1368349A (en) | Nano medicine 'Huodan Biyan' and its preparing process | |
| CN1368310A (en) | Nano medicine 'Tianma Mihuanjun' and its preparing process | |
| CN1364500A (en) | Nano sanliangban medicine and its preparing method | |
| CN1368117A (en) | Nano medicine for developing infantile intelligence and its preparing process | |
| CN1368215A (en) | Nano medicine 'Compound Dahuang' and its preparing process | |
| CN1368071A (en) | Nano medicine 'Qianzihong' and its preparing process | |
| CN1364581A (en) | Nano Children heat fast clearing away medicine and its preparing method | |
| CN1365713A (en) | Nano medicine for treating ulcer and its preparing process | |
| CN1368127A (en) | Nano medicine 'Liandanxiaoyan' and its preparing process | |
| CN1368352A (en) | Nano medicine 'Guanxinning' and its preparing process | |
| CN1365736A (en) | Nano medicine for treating coronary heart disease and its preparing process | |
| CN1368070A (en) | Nano antitussive medicine 'Jinbaohong' and its preparing process | |
| CN1368276A (en) | Nano medicine 'Zhike Pipa' and its preparing process | |
| CN1365729A (en) | Nano medicine for treating laryngalgia and its preparing process | |
| CN1368218A (en) | Nano compound medicine for treating hepatitides and its preparing process | |
| CN1368351A (en) | Nano medicine 'Hexue' and its preparing process | |
| CN1368121A (en) | Nano medicine 'Jinzeguanxin' and its preparing process | |
| CN1368338A (en) | Nano medicine 'Quick-acting Xintong' and its preparing process | |
| CN1365769A (en) | Nano medicine 'Kanggan' and its preparing process | |
| CN1368138A (en) | Nano safflower medicine and its preparing process | |
| CN1368052A (en) | Nano medicine 'Gansukang' and its preparing process |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |