CN1366952A - Nano Fengshi Guanjie preparation medicine and preparation method - Google Patents
Nano Fengshi Guanjie preparation medicine and preparation method Download PDFInfo
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- CN1366952A CN1366952A CN 01102148 CN01102148A CN1366952A CN 1366952 A CN1366952 A CN 1366952A CN 01102148 CN01102148 CN 01102148 CN 01102148 A CN01102148 A CN 01102148A CN 1366952 A CN1366952 A CN 1366952A
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- 239000003814 drug Substances 0.000 title claims abstract description 45
- 238000002360 preparation method Methods 0.000 title claims abstract description 22
- 239000000463 material Substances 0.000 claims abstract description 20
- 238000000034 method Methods 0.000 claims abstract description 12
- 239000002994 raw material Substances 0.000 claims abstract description 6
- 238000001694 spray drying Methods 0.000 claims abstract description 5
- 229940079593 drug Drugs 0.000 claims description 19
- 241000213006 Angelica dahurica Species 0.000 claims description 8
- 241000208340 Araliaceae Species 0.000 claims description 8
- 241000903946 Clematidis Species 0.000 claims description 8
- 244000113306 Monascus purpureus Species 0.000 claims description 8
- 235000002322 Monascus purpureus Nutrition 0.000 claims description 8
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 claims description 8
- 235000003140 Panax quinquefolius Nutrition 0.000 claims description 8
- 235000008331 Pinus X rigitaeda Nutrition 0.000 claims description 8
- 235000011613 Pinus brutia Nutrition 0.000 claims description 8
- 241000018646 Pinus brutia Species 0.000 claims description 8
- 235000008434 ginseng Nutrition 0.000 claims description 8
- 229940057059 monascus purpureus Drugs 0.000 claims description 8
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- 239000000843 powder Substances 0.000 claims description 7
- 239000008187 granular material Substances 0.000 claims description 6
- 239000012528 membrane Substances 0.000 claims description 6
- 239000006187 pill Substances 0.000 claims description 6
- 238000000605 extraction Methods 0.000 claims description 5
- 239000002904 solvent Substances 0.000 claims description 5
- 241000753128 Periploca <moth> Species 0.000 claims description 4
- 241001180876 Saposhnikovia Species 0.000 claims description 4
- 239000012141 concentrate Substances 0.000 claims description 4
- 235000008504 concentrate Nutrition 0.000 claims description 4
- 238000001035 drying Methods 0.000 claims description 4
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- 238000002156 mixing Methods 0.000 claims description 4
- VYQNWZOUAUKGHI-UHFFFAOYSA-N monobenzone Chemical compound C1=CC(O)=CC=C1OCC1=CC=CC=C1 VYQNWZOUAUKGHI-UHFFFAOYSA-N 0.000 claims description 4
- 239000000443 aerosol Substances 0.000 claims description 3
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- 238000002347 injection Methods 0.000 claims description 3
- 239000007924 injection Substances 0.000 claims description 3
- 239000003094 microcapsule Substances 0.000 claims description 3
- 239000002674 ointment Substances 0.000 claims description 3
- 229940100688 oral solution Drugs 0.000 claims description 3
- 239000000829 suppository Substances 0.000 claims description 3
- 239000006188 syrup Substances 0.000 claims description 3
- 235000020357 syrup Nutrition 0.000 claims description 3
- 239000003826 tablet Substances 0.000 claims description 3
- 239000003390 Chinese drug Substances 0.000 claims 2
- 241000173529 Aconitum napellus Species 0.000 abstract 1
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- 241000365112 Monsonia angustifolia Species 0.000 abstract 1
- 229940023019 aconite Drugs 0.000 abstract 1
- 235000004879 dioscorea Nutrition 0.000 abstract 1
- 238000000874 microwave-assisted extraction Methods 0.000 abstract 1
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- 208000008035 Back Pain Diseases 0.000 description 2
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Abstract
The present invention discloses a nano Fengshi Guanjie preparation medicine. It is made up by using 23 Chinese medicinal materials of nano black-striped snake, nano wild aconite, nano cranesbill, nano Japanese dioscorea, nano notopterygium as raw material through the processes of microwave extraction, reduced pressure concentration and supersonic jet spray drying. Its grain fineness is up to 1200-1500 meshes, grain size is 0.1-200 nm, in which most of grain size is less than 100 nm.
Description
The present invention relates to the nano Fengshi Guanjie preparation medicine of a kind of wind dispelling cold expelling, promoting blood circulation and stopping pain, the invention still further relates to the method for this medication preparation.
Fengshi Guanjie wine is a kind of classical Chinese patent medicine, mainly contains effects such as wind dispelling cold expelling, promoting blood circulation and stopping pain, is used for wind-cold damp pathogen and causes: arthralgia, shoulder back of the body acid precipitation, lumbago rheumatism in the legs, numb limbs and tense tendons, the contracture of muscle arteries and veins.But traditional Fengshi Guanjie wine absorbs not exclusively, and bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully the nano Fengshi Guanjie preparation medicine of increase evident in efficacy.
Another object of the present invention provides the preparation method of this nano Fengshi Guanjie preparation medicine.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
Nanometer Zaocys 100-200 part nanometer Radix Aconiti Kusnezoffii 60-150 part nanometer Herba Erodii 150-400 part
Nanometer Rhizoma Dioscoreae Nipponicae 150-400 part nanometer Rhizoma Et Radix Notopterygii 60-150 part nanometer Radix Angelicae Pubescentis 60-150 part
Nanometer Radix Clematidis 40-95 part nanometer Cortex Periplocae 150-400 part nanometer Fructus Chaenomelis 40-90 part
Nanometer Rhizoma Atractylodis 100-200 part nanometer Radix Saposhnikoviae 80-180 part nanometer Pine Nodular Branch 100-200 part
Nano Chinese angelica 100-200 part nanometer Rhizoma Chuanxiong 100-200 part nanometer Ramulus Cinnamomi 60-150 part
Nanometer Caulis Spatholobi 80-180 part nanometer Radix Achyranthis Bidentatae 60-150 part nanometer Radix Paeoniae Alba 100-250 part
Nanometric Hypoglaucous Collett Yam Rhizome 100-250 part nanometer Fructus Citri Sarcodactylis 100-250 part nano ginseng 80-180 part
Nanometer Radix Glycyrrhizae 80-180 part nanometer Monas cuspurpureus Went 150-400 part
The formula optimization weight proportion scope of medicine of the present invention is:
Nanometer Zaocys 120-180 part nanometer Radix Aconiti Kusnezoffii 80-120 part nanometer Herba Erodii 200-300 part
Nanometer Rhizoma Dioscoreae Nipponicae 200-300 part nanometer Rhizoma Et Radix Notopterygii 80-120 part nanometer Radix Angelicae Pubescentis 80-120 part
Nanometer Radix Clematidis 50-90 part nanometer Cortex Periplocae 200-300 part nanometer Fructus Chaenomelis 50-80 part
Nanometer Rhizoma Atractylodis 120-180 part nanometer Radix Saposhnikoviae 100-150 part nanometer Pine Nodular Branch 120-180 part
Nano Chinese angelica 120-180 part nanometer Rhizoma Chuanxiong 120-180 part nanometer Ramulus Cinnamomi 80-120 part
Nanometer Caulis Spatholobi 100-150 part nanometer Radix Achyranthis Bidentatae 80-120 part nanometer Radix Paeoniae Alba 120-180 part
Nanometric Hypoglaucous Collett Yam Rhizome 120-180 part nanometer Fructus Citri Sarcodactylis 120-180 part nano ginseng 100-150 part
Nanometer Radix Glycyrrhizae 100-150 part nanometer Monas cuspurpureus Went 200-300 part
The optimum weight proportioning of medicine of the present invention is:
250 parts of 93.75 parts of nanometer Herba Erodiis of 156.25 parts of nanometer Radix Aconiti Kusnezoffii of nanometer Zaocys
93.75 parts of 93.75 parts of nanometer Radix Angelicae Pubescentiss of 250 parts of nanometer Rhizoma Et Radix Notopterygiis of nanometer Rhizoma Dioscoreae Nipponicae
62.5 parts of 250 parts of nanometer Fructus Chaenomeliss of 62.5 parts of nanometer Cortex Periplocaes of nanometer Radix Clematidis
156.25 parts of 125 parts of nanometer Pine Nodular Branchs of 156.25 parts of nanometer Radix Saposhnikoviaes of nanometer Rhizoma Atractylodis
93.75 parts of 156.25 parts of nanometer Ramulus Cinnamomi of 156.25 parts of nanometer Rhizoma Chuanxiongs of nano Chinese angelica
156.25 parts of 93.75 parts of nanometer Radix Paeoniae Albas of 125 parts of nanometer Radix Achyranthis Bidentataes of nanometer Caulis Spatholobi
125 parts of 156.25 parts of nano ginsengs of 156.25 parts of nanometer Fructus Citri Sarcodactylis of nanometric Hypoglaucous Collett Yam Rhizome
250 parts in 125 parts of nanometer Monas cuspurpureus Went of nanometer Radix Glycyrrhizae
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material be since special construction----the material grains size of nano material less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15--50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, be processed into the common Chinese decoction pieces according to process of preparing Chinese medicine of Chinese Pharmacopoeia version in 2000.
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃--and 60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, promptly make the nanometer prepared slices of Chinese crude drugs with hypersonic velocity instantaneous jet drying.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its little liquid extraction is 30 ℃-60 ℃, time 1-10 hour:
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, get Fengshi Guanjie preparation nano powder with hypersonic velocity instantaneous jet drying;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
The pharmacological effect that above-mentioned two kinds of methods are made the nano Fengshi Guanjie preparation medicine is identical.
A kind of important feature of the present invention is: the made drug material of the present invention has reached nanoscale, common Fengshi Guanjie liquor preparation material is micron or the above particle diameter of millimeter, can only cross the 80-120 mesh sieve, the drug material that the present invention is made, particle diameter is at 0.1--200nm, the overwhelming majority can be crossed the 1200--1500 mesh sieve less than 100nm.
Another important feature of the present invention is: solid preparation of the present invention disintegrate rapidly, and solid dispersion is good in water, absorb fully, the bioavailability height, the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also created the novel form that pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, syrup, oral solution of nano Fengshi Guanjie preparation medicine etc. had no precedent in the past.
Pharmaceutical preparation of the present invention can be used for wind-cold damp pathogen and causes: treatment of conditions such as arthralgia, shoulder back of the body acid precipitation, lumbago rheumatism in the legs, numb limbs and tense tendons, the contracture of muscle arteries and veins, clinical efficacy significantly is better than traditional Fengshi Guanjie wine.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment 1:
Prepare nano raw material by preceding method:
250 parts of 93.75 parts of nanometer Herba Erodiis of 156.25 parts of nanometer Radix Aconiti Kusnezoffii of nanometer Zaocys
93.75 parts of 93.75 parts of nanometer Radix Angelicae Pubescentiss of 250 parts of nanometer Rhizoma Et Radix Notopterygiis of nanometer Rhizoma Dioscoreae Nipponicae
62.5 parts of 250 parts of nanometer Fructus Chaenomeliss of 62.5 parts of nanometer Cortex Periplocaes of nanometer Radix Clematidis
156.25 parts of 125 parts of nanometer Pine Nodular Branchs of 156.25 parts of nanometer Radix Saposhnikoviaes of nanometer Rhizoma Atractylodis
93.75 parts of 156.25 parts of nanometer Ramulus Cinnamomi of 156.25 parts of nanometer Rhizoma Chuanxiongs of nano Chinese angelica
156.25 parts of 93.75 parts of nanometer Radix Paeoniae Albas of 125 parts of nanometer Radix Achyranthis Bidentataes of nanometer Caulis Spatholobi
125 parts of 156.25 parts of nano ginsengs of 156.25 parts of nanometer Fructus Citri Sarcodactylis of nanometric Hypoglaucous Collett Yam Rhizome
250 parts in 125 parts of nanometer Monas cuspurpureus Went of nanometer Radix Glycyrrhizae
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, do not granulate, directly divide encapsulated with the fully-automatic capsule racking machine, make capsule, every capsules content of dispersion is the 0.1--0.6 gram, and the patient takes the 1-5 grain at every turn, and take 1-4 every day.
Embodiment 2:
Prepare nano raw material by preceding method:
250 parts of 93.75 parts of nanometer Herba Erodiis of 156.25 parts of nanometer Radix Aconiti Kusnezoffii of nanometer Zaocys
93.75 parts of 93.75 parts of nanometer Radix Angelicae Pubescentiss of 250 parts of nanometer Rhizoma Et Radix Notopterygiis of nanometer Rhizoma Dioscoreae Nipponicae
62.5 parts of 250 parts of nanometer Fructus Chaenomeliss of 62.5 parts of nanometer Cortex Periplocaes of nanometer Radix Clematidis
156.25 parts of 125 parts of nanometer Pine Nodular Branchs of 156.25 parts of nanometer Radix Saposhnikoviaes of nanometer Rhizoma Atractylodis
93.75 parts of 156.25 parts of nanometer Ramulus Cinnamomi of 156.25 parts of nanometer Rhizoma Chuanxiongs of nano Chinese angelica
156.25 parts of 93.75 parts of nanometer Radix Paeoniae Albas of 125 parts of nanometer Radix Achyranthis Bidentataes of nanometer Caulis Spatholobi
125 parts of 156.25 parts of nano ginsengs of 156.25 parts of nanometer Fructus Citri Sarcodactylis of nanometric Hypoglaucous Collett Yam Rhizome
250 parts in 125 parts of nanometer Monas cuspurpureus Went of nanometer Radix Glycyrrhizae
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or powder by described mixed good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia membrane standard, filmogen adopts polyvinyl alcohol, make the nano Fengshi Guanjie membrane, every membrane area size is the 2-100 square centimeter, and content of dispersion is the 1-50 gram, every medicine film pasted 1-7 days, pasted the medicine position: the affected part.
Claims (6)
1, a kind of nano Fengshi Guanjie preparation medicine is characterized in that it is the medicament that the nano raw material of following weight proportioning is made:
Nanometer Zaocys 100-200 part nanometer Radix Aconiti Kusnezoffii 60-150 part nanometer Herba Erodii 150-400 part
Nanometer Rhizoma Dioscoreae Nipponicae 150-400 part nanometer Rhizoma Et Radix Notopterygii 60-150 part nanometer Radix Angelicae Pubescentis 60-150 part
Nanometer Radix Clematidis 40-95 part nanometer Cortex Periplocae 150-400 part nanometer Fructus Chaenomelis 40-90 part
Nanometer Rhizoma Atractylodis 100-200 part nanometer Radix Saposhnikoviae 80-180 part nanometer Pine Nodular Branch 100-200 part
Nano Chinese angelica 100-200 part nanometer Rhizoma Chuanxiong 100-200 part nanometer Ramulus Cinnamomi 60-150 part
Nanometer Caulis Spatholobi 80-180 part nanometer Radix Achyranthis Bidentatae 60-150 part nanometer Radix Paeoniae Alba 100-250 part
Nanometric Hypoglaucous Collett Yam Rhizome 100-250 part nanometer Fructus Citri Sarcodactylis 100-250 part nano ginseng 80-180 part
Nanometer Radix Glycyrrhizae 80-180 part nanometer Monas cuspurpureus Went 150-400 part
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
2, nano Fengshi Guanjie preparation medicine according to claim 1, wherein the weight proportion of each nano raw material is:
Nanometer Zaocys 120-180 part nanometer Radix Aconiti Kusnezoffii 80-120 part nanometer Herba Erodii 200-300 part
Nanometer Rhizoma Dioscoreae Nipponicae 200-300 part nanometer Rhizoma Et Radix Notopterygii 80-120 part nanometer Radix Angelicae Pubescentis 80-120 part
Nanometer Radix Clematidis 50-90 part nanometer Cortex Periplocae 200-300 part nanometer Fructus Chaenomelis 50-80 part
Nanometer Rhizoma Atractylodis 120-180 part nanometer Radix Saposhnikoviae 100-150 part nanometer Pine Nodular Branch 120-180 part
Nano Chinese angelica 120-180 part nanometer Rhizoma Chuanxiong 120-180 part nanometer Ramulus Cinnamomi 80-120 part
Nanometer Caulis Spatholobi 100-150 part nanometer Radix Achyranthis Bidentatae 80-120 part nanometer Radix Paeoniae Alba 120-180 part
Nanometric Hypoglaucous Collett Yam Rhizome 120-180 part nanometer Fructus Citri Sarcodactylis 120-180 part nano ginseng 100-150 part
Nanometer Radix Glycyrrhizae 100-150 part nanometer Monas cuspurpureus Went 200-300 part
3, nano Fengshi Guanjie preparation medicine according to claim 1, wherein the weight proportion of each nano raw material is:
250 parts of 93.75 parts of nanometer Herba Erodiis of 156.25 parts of nanometer Radix Aconiti Kusnezoffii of nanometer Zaocys
93.75 parts of 93.75 parts of nanometer Radix Angelicae Pubescentiss of 250 parts of nanometer Rhizoma Et Radix Notopterygiis of nanometer Rhizoma Dioscoreae Nipponicae
62.5 parts of 250 parts of nanometer Fructus Chaenomeliss of 62.5 parts of nanometer Cortex Periplocaes of nanometer Radix Clematidis
156.25 parts of 125 parts of nanometer Pine Nodular Branchs of 156.25 parts of nanometer Radix Saposhnikoviaes of nanometer Rhizoma Atractylodis
93.75 parts of 156.25 parts of nanometer Ramulus Cinnamomi of 156.25 parts of nanometer Rhizoma Chuanxiongs of nano Chinese angelica
156.25 parts of 93.75 parts of nanometer Radix Paeoniae Albas of 125 parts of nanometer Radix Achyranthis Bidentataes of nanometer Caulis Spatholobi
125 parts of 156.25 parts of nano ginsengs of 156.25 parts of nanometer Fructus Citri Sarcodactylis of nanometric Hypoglaucous Collett Yam Rhizome
250 parts in 125 parts of nanometer Monas cuspurpureus Went of nanometer Radix Glycyrrhizae
4,, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution according to claim 1 or 2 or 3 described nano Fengshi Guanjie preparation medicines.
5,, it is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs according to the pharmaceutical methods of claim 1 or 2 or 3 described nano Fengshi Guanjie preparation medicines; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
6, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01102148 CN1366952A (en) | 2001-01-20 | 2001-01-20 | Nano Fengshi Guanjie preparation medicine and preparation method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01102148 CN1366952A (en) | 2001-01-20 | 2001-01-20 | Nano Fengshi Guanjie preparation medicine and preparation method |
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| Publication Number | Publication Date |
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| CN1366952A true CN1366952A (en) | 2002-09-04 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN 01102148 Pending CN1366952A (en) | 2001-01-20 | 2001-01-20 | Nano Fengshi Guanjie preparation medicine and preparation method |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1322877C (en) * | 2003-09-16 | 2007-06-27 | 郁华堂 | Caspule for treating fibrositis |
-
2001
- 2001-01-20 CN CN 01102148 patent/CN1366952A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1322877C (en) * | 2003-09-16 | 2007-06-27 | 郁华堂 | Caspule for treating fibrositis |
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