CN1365680A - Nano medicine 'Suzi Jingqi' and its preparing process - Google Patents
Nano medicine 'Suzi Jingqi' and its preparing process Download PDFInfo
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- CN1365680A CN1365680A CN 01100299 CN01100299A CN1365680A CN 1365680 A CN1365680 A CN 1365680A CN 01100299 CN01100299 CN 01100299 CN 01100299 A CN01100299 A CN 01100299A CN 1365680 A CN1365680 A CN 1365680A
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- 239000003814 drug Substances 0.000 title claims abstract description 45
- 238000000034 method Methods 0.000 title claims description 12
- 239000000463 material Substances 0.000 claims abstract description 20
- 239000000843 powder Substances 0.000 claims abstract description 11
- 238000001694 spray drying Methods 0.000 claims abstract description 5
- 229940079593 drug Drugs 0.000 claims description 18
- 241000213006 Angelica dahurica Species 0.000 claims description 9
- 239000006187 pill Substances 0.000 claims description 9
- 239000002775 capsule Substances 0.000 claims description 7
- 239000008187 granular material Substances 0.000 claims description 6
- 238000002347 injection Methods 0.000 claims description 6
- 239000007924 injection Substances 0.000 claims description 6
- 239000012528 membrane Substances 0.000 claims description 6
- 238000002156 mixing Methods 0.000 claims description 6
- 239000002994 raw material Substances 0.000 claims description 6
- 239000002904 solvent Substances 0.000 claims description 5
- 239000012141 concentrate Substances 0.000 claims description 4
- 235000008504 concentrate Nutrition 0.000 claims description 4
- 238000001035 drying Methods 0.000 claims description 4
- 238000000605 extraction Methods 0.000 claims description 4
- 230000008676 import Effects 0.000 claims description 4
- 239000000443 aerosol Substances 0.000 claims description 3
- 239000006196 drop Substances 0.000 claims description 3
- 239000000796 flavoring agent Substances 0.000 claims description 3
- 235000019634 flavors Nutrition 0.000 claims description 3
- 239000003094 microcapsule Substances 0.000 claims description 3
- 229940100688 oral solution Drugs 0.000 claims description 3
- 239000000829 suppository Substances 0.000 claims description 3
- 239000006188 syrup Substances 0.000 claims description 3
- 235000020357 syrup Nutrition 0.000 claims description 3
- 239000003826 tablet Substances 0.000 claims description 3
- 239000002674 ointment Substances 0.000 claims description 2
- 239000003390 Chinese drug Substances 0.000 claims 2
- 230000000694 effects Effects 0.000 abstract description 9
- 235000004347 Perilla Nutrition 0.000 abstract description 5
- 241001673966 Magnolia officinalis Species 0.000 abstract 1
- 244000124853 Perilla frutescens Species 0.000 abstract 1
- 241000244269 Peucedanum Species 0.000 abstract 1
- 241001522129 Pinellia Species 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 description 7
- 230000001088 anti-asthma Effects 0.000 description 5
- 239000000924 antiasthmatic agent Substances 0.000 description 5
- 239000003795 chemical substances by application Substances 0.000 description 5
- 241000229722 Perilla <angiosperm> Species 0.000 description 4
- 208000006673 asthma Diseases 0.000 description 4
- 235000013399 edible fruits Nutrition 0.000 description 4
- 238000005516 engineering process Methods 0.000 description 4
- 206010011224 Cough Diseases 0.000 description 3
- 239000002671 adjuvant Substances 0.000 description 3
- 238000004140 cleaning Methods 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 239000002245 particle Substances 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 230000000954 anitussive effect Effects 0.000 description 2
- 229940124584 antitussives Drugs 0.000 description 2
- 239000013078 crystal Substances 0.000 description 2
- ZZVUWRFHKOJYTH-UHFFFAOYSA-N diphenhydramine Chemical compound C=1C=CC=CC=1C(OCCN(C)C)C1=CC=CC=C1 ZZVUWRFHKOJYTH-UHFFFAOYSA-N 0.000 description 2
- 239000006185 dispersion Substances 0.000 description 2
- 230000003203 everyday effect Effects 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 239000011858 nanopowder Substances 0.000 description 2
- 239000000825 pharmaceutical preparation Substances 0.000 description 2
- 230000000144 pharmacologic effect Effects 0.000 description 2
- 239000007962 solid dispersion Substances 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 208000031361 Hiccup Diseases 0.000 description 1
- 206010062717 Increased upper airway secretion Diseases 0.000 description 1
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- 206010036790 Productive cough Diseases 0.000 description 1
- 230000003187 abdominal effect Effects 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 230000003266 anti-allergic effect Effects 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 229940126678 chinese medicines Drugs 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 230000002500 effect on skin Effects 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 239000002086 nanomaterial Substances 0.000 description 1
- 239000002547 new drug Substances 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 208000026435 phlegm Diseases 0.000 description 1
- 208000008423 pleurisy Diseases 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 208000024794 sputum Diseases 0.000 description 1
- 210000003802 sputum Anatomy 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000010792 warming Methods 0.000 description 1
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- Medicinal Preparation (AREA)
Abstract
A nanometre medicine "Suzijiangqi" is prepared from the nanometre powders of 10 Chinese medicinal materials including perilla seed, pinellia tuber, magnolia bark, peucedanum root, etc. through proportioning, microwave extracting, pressure reduction concentrating and supersonic-jet spray drying. Its grain fineness reaches 1200-1500 meshes and grain diameters are 0.1-200 nm. Its advantages include high biological utilization rate and high curative effect.
Description
The present invention relates to a kind of lowering the adverse-rising QI to resolve phlegm, the kidney warming improving inspiration by invigorating kidney-QI, antitussive and antiasthmatic, cure mainly the nano medicine ' Suzi Jingqi ' of cough with asthma, the invention still further relates to the method for this medication preparation.
Antiasthmatic pill of perilla fruit is a kind of classical Chinese patent medicine, mainly contains antitussive, relievings asthma, antiinflammatory, antiallergic and influence effect such as body's immunity, is used for cough with asthma, accumulation and obstruction of sputum, full vexed, the white and slippery fur or white greasy of chest and diaphragm.But traditional antiasthmatic pill of perilla fruit disintegrate is slower, absorbs not exclusively, and bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully the nano medicine ' Suzi Jingqi ' of increase evident in efficacy.
Another object of the present invention provides the preparation method of this nano medicine ' Suzi Jingqi '.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
Nanometer Fructus Perillae (parched) 10-50 part nanometer processed with Rhizoma Zingiberis Recens Rhizoma Pinelliae 15-60 part nanometer Cortex Magnoliae Officinalis 8-50 part
Nanometer Radix Peucedani 10-50 part nanometer Pericarpium Citri Reticulatae 5-40 part nano Chinese angelica 8-40 part
Nanometer Radix Glycyrrhizae 5-40 part nanometer Rhizoma Zingiberis Recens 10-50 part nanometer Fructus Jujubae 10-50 part
Nanometer Lignum Aquilariae Resinatum 8-50 part
The formula optimization weight proportion scope of medicine of the present invention is:
Nanometer Fructus Perillae (parched) 20-40 part nanometer processed with Rhizoma Zingiberis Recens Rhizoma Pinelliae 25-50 part nanometer Cortex Magnoliae Officinalis 15-40 part
Nanometer Radix Peucedani 20-40 part nanometer Pericarpium Citri Reticulatae 10-30 part nano Chinese angelica 15-40 part
Nanometer Radix Glycyrrhizae 8-30 part nanometer Rhizoma Zingiberis Recens 20-40 part nanometer Fructus Jujubae 20-40 part
Nanometer Lignum Aquilariae Resinatum 15-40 part
The optimum weight proportioning of medicine of the present invention is:
25 parts of 35 parts of nanometer Cortex Magnoliae Officinalis of 30 parts of nanometer processed with Rhizoma Zingiberis Recens of nanometer Fructus Perillae (parched) Rhizoma Pinelliae
25 parts of 20 parts of nano Chinese angelicas of 28 parts of nanometer Pericarpium Citri Reticulataes of nanometer Radix Peucedani
30 parts in 28 portions of nanometer Fructus Jujubaes of 15 portions of nanometer Rhizoma Zingiberis Recenss of nanometer Radix Glycyrrhizae
26 parts of nanometer Lignum Aquilariae Resinatum
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material is because the special construction of nano material---the particle size of material is less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15%-50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, add to concoct according to Chinese Pharmacopoeia one one of version in 2000 and be processed into the common Chinese decoction pieces
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20-30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃-60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters-990 meter per seconds of effluxvelocity, 30 ℃ of-60 ℃ of temperature, under 0 to the 0.05MPa pressure,, promptly make the nanometer prepared slices of Chinese crude drugs with the instantaneous drying of hypersonic velocity.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20-30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃-60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters-990 meter per seconds of effluxvelocity, 30 ℃ of-60 ℃ of temperature, under 0 to the 0.05MPa pressure,, get the 'Suzi Jingqi ' nano powder with the instantaneous drying of hypersonic velocity jet;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
The pharmacological effect that above-mentioned two kinds of methods are made nano medicine ' Suzi Jingqi ' is identical.
A kind of important feature of the present invention is: the made drug material of the present invention has reached nanoscale, common antiasthmatic pill of perilla fruit preparation material is micron or the above particle diameter of millimeter, can only cross the 80-120 mesh sieve, the drug material that the present invention is made, particle diameter is at 0.1-200nm, the overwhelming majority can be crossed the 1200-1500 mesh sieve less than 100nm.
Another important feature of the present invention is: solid preparation of the present invention disintegrate rapidly, and solid dispersion is good in water, absorb fully, the bioavailability height, the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also created the new drug formulation that powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, medicated wine, syrup, oral solution of nano medicine ' Suzi Jingqi ' etc. is had no precedent in the past.
Pharmaceutical preparation of the present invention can be used for treatment of conditions such as cough with asthma, singultus, pleuritis, oesphageal bulb, and clinical efficacy significantly is better than traditional antiasthmatic pill of perilla fruit.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment 1:
Prepare nano raw material by preceding method:
25 parts of 35 parts of nanometer Cortex Magnoliae Officinalis of 30 parts of nanometer processed with Rhizoma Zingiberis Recens of nanometer Fructus Perillae (parched) Rhizoma Pinelliae
25 parts of 20 parts of nano Chinese angelicas of 28 parts of nanometer Pericarpium Citri Reticulataes of nanometer Radix Peucedani
30 parts in 28 portions of nanometer Fructus Jujubaes of 15 portions of nanometer Rhizoma Zingiberis Recenss of nanometer Radix Glycyrrhizae
26 parts of nanometer Lignum Aquilariae Resinatum
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, do not granulate, directly divide encapsulated with the fully-automatic capsule racking machine, make capsule, every capsules content of dispersion is the 0.1-0.6 gram, and the patient takes 1-4 time every day, each 1-5 grain.
Embodiment 2:
Prepare nano raw material by preceding method:
25 parts of 35 parts of nanometer Cortex Magnoliae Officinalis of 30 parts of nanometer processed with Rhizoma Zingiberis Recens of nanometer Fructus Perillae (parched) Rhizoma Pinelliae
25 parts of 20 parts of nano Chinese angelicas of 28 parts of nanometer Pericarpium Citri Reticulataes of nanometer Radix Peucedani
30 parts in 28 portions of nanometer Fructus Jujubaes of 15 portions of nanometer Rhizoma Zingiberis Recenss of nanometer Radix Glycyrrhizae
26 parts of nanometer Lignum Aquilariae Resinatum
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent powder needle injection standard, do not add any adjuvant, make nanometer perillaseed droping gas powder needle injection, every injection content is the 5-20 milligram, and each consumption is that 1-2 props up, and use 1-3 every day.
Embodiment 3:
Prepare nano raw material by preceding method:
25 parts of 35 parts of nanometer Cortex Magnoliae Officinalis of 30 parts of nanometer processed with Rhizoma Zingiberis Recens of nanometer Fructus Perillae (parched) Rhizoma Pinelliae
25 parts of 20 parts of nano Chinese angelicas of 28 parts of nanometer Pericarpium Citri Reticulataes of nanometer Radix Peucedani
30 parts in 28 portions of nanometer Fructus Jujubaes of 15 portions of nanometer Rhizoma Zingiberis Recenss of nanometer Radix Glycyrrhizae
26 parts of nanometer Lignum Aquilariae Resinatum
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent membrane standard, filmogen adopts polyvinyl alcohol, make nanometer perillaseed droping gas membrane, every membrane area size is the 2-100 square centimeter, and content of dispersion is the 1-50 gram, every medicine film pasted 1-7 days, pasted the medicine position: abdominal part.
Claims (6)
1, a kind of nano medicine ' Suzi Jingqi ' is characterized in that it is the medicament that the nano raw material of following weight proportioning is made:
Nanometer Fructus Perillae (parched) 10-50 part nanometer processed with Rhizoma Zingiberis Recens Rhizoma Pinelliae 15-60 part nanometer Cortex Magnoliae Officinalis 8-50 part
Nanometer Radix Peucedani 10-50 part nanometer Pericarpium Citri Reticulatae 5-40 part nano Chinese angelica 8-40 part
Nanometer Radix Glycyrrhizae 5-40 part nanometer Rhizoma Zingiberis Recens 10-50 part nanometer Fructus Jujubae 10-50 part
Nanometer Lignum Aquilariae Resinatum 8-50 part
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1--10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3--72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters--990 meter per seconds, promptly make the nanometer prepared slices of Chinese crude drugs.
2, nano medicine ' Suzi Jingqi ' according to claim 1, wherein the weight proportion of each nano raw material is:
Nanometer Fructus Perillae (parched) 20-40 part nanometer processed with Rhizoma Zingiberis Recens Rhizoma Pinelliae 25-50 part nanometer Cortex Magnoliae Officinalis 15-40 part
Nanometer Radix Peucedani 20-40 part nanometer Pericarpium Citri Reticulatae 10-30 part nano Chinese angelica 15-40 part
Nanometer Radix Glycyrrhizae 8-30 part nanometer Rhizoma Zingiberis Recens 20-40 part nanometer Fructus Jujubae 20-40 part
Nanometer Lignum Aquilariae Resinatum 15-40 part
3, nano medicine ' Suzi Jingqi ' according to claim 1, wherein the weight proportion of each nano raw material is:
25 parts of 35 parts of nanometer Cortex Magnoliae Officinalis of 30 parts of nanometer processed with Rhizoma Zingiberis Recens of nanometer Fructus Perillae (parched) Rhizoma Pinelliae
25 parts of 20 parts of nano Chinese angelicas of 28 parts of nanometer Pericarpium Citri Reticulataes of nanometer Radix Peucedani
30 parts in 28 portions of nanometer Fructus Jujubaes of 15 portions of nanometer Rhizoma Zingiberis Recenss of nanometer Radix Glycyrrhizae
26 parts of nanometer Lignum Aquilariae Resinatum
4,, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution according to claim 1 or 2 or 3 described nano medicine ' Suzi Jingqi 's.
5,, it is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs according to the pharmaceutical methods of claim 1 or 2 or 3 described nano medicine ' Suzi Jingqi 's; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1--10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3--72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters--990 meter per seconds, promptly make the nanometer prepared slices of Chinese crude drugs.
6, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100299 CN1365680A (en) | 2001-01-18 | 2001-01-18 | Nano medicine 'Suzi Jingqi' and its preparing process |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100299 CN1365680A (en) | 2001-01-18 | 2001-01-18 | Nano medicine 'Suzi Jingqi' and its preparing process |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1365680A true CN1365680A (en) | 2002-08-28 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 01100299 Pending CN1365680A (en) | 2001-01-18 | 2001-01-18 | Nano medicine 'Suzi Jingqi' and its preparing process |
Country Status (1)
| Country | Link |
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| CN (1) | CN1365680A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103656016A (en) * | 2013-12-22 | 2014-03-26 | 青岛琴诚医药技术有限公司 | Preparation method and application of perillaseed qi depressing pellet |
-
2001
- 2001-01-18 CN CN 01100299 patent/CN1365680A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103656016A (en) * | 2013-12-22 | 2014-03-26 | 青岛琴诚医药技术有限公司 | Preparation method and application of perillaseed qi depressing pellet |
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