CN1362131A - Nano pus drawing out medicine and its preparation - Google Patents
Nano pus drawing out medicine and its preparation Download PDFInfo
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- CN1362131A CN1362131A CN 01100184 CN01100184A CN1362131A CN 1362131 A CN1362131 A CN 1362131A CN 01100184 CN01100184 CN 01100184 CN 01100184 A CN01100184 A CN 01100184A CN 1362131 A CN1362131 A CN 1362131A
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- 239000003814 drug Substances 0.000 title claims abstract description 44
- 238000002360 preparation method Methods 0.000 title claims abstract description 20
- 239000000463 material Substances 0.000 claims abstract description 20
- 238000000034 method Methods 0.000 claims abstract description 10
- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 claims abstract description 5
- 239000002994 raw material Substances 0.000 claims abstract description 5
- 238000001694 spray drying Methods 0.000 claims abstract description 5
- 239000011505 plaster Substances 0.000 claims description 17
- 229940079593 drug Drugs 0.000 claims description 16
- 241000717739 Boswellia sacra Species 0.000 claims description 7
- 241000287828 Gallus gallus Species 0.000 claims description 7
- 241001057584 Myrrha Species 0.000 claims description 7
- 241000972673 Phellodendron amurense Species 0.000 claims description 7
- 229940056582 human hair preparation Drugs 0.000 claims description 7
- 210000000582 semen Anatomy 0.000 claims description 7
- 239000012528 membrane Substances 0.000 claims description 6
- 239000006187 pill Substances 0.000 claims description 6
- 239000000843 powder Substances 0.000 claims description 6
- 239000008187 granular material Substances 0.000 claims description 5
- 239000002904 solvent Substances 0.000 claims description 5
- 241001161070 Calomela Species 0.000 claims description 4
- 239000004863 Frankincense Substances 0.000 claims description 4
- 239000012141 concentrate Substances 0.000 claims description 4
- 235000008504 concentrate Nutrition 0.000 claims description 4
- 238000001035 drying Methods 0.000 claims description 4
- 238000000605 extraction Methods 0.000 claims description 4
- 230000008676 import Effects 0.000 claims description 4
- 238000002156 mixing Methods 0.000 claims description 4
- 241000405217 Viola <butterfly> Species 0.000 claims description 3
- 239000000443 aerosol Substances 0.000 claims description 3
- 239000002775 capsule Substances 0.000 claims description 3
- 239000006196 drop Substances 0.000 claims description 3
- 239000000796 flavoring agent Substances 0.000 claims description 3
- 235000019634 flavors Nutrition 0.000 claims description 3
- 238000002347 injection Methods 0.000 claims description 3
- 239000007924 injection Substances 0.000 claims description 3
- 239000003094 microcapsule Substances 0.000 claims description 3
- 229940100688 oral solution Drugs 0.000 claims description 3
- 239000000829 suppository Substances 0.000 claims description 3
- 239000006188 syrup Substances 0.000 claims description 3
- 235000020357 syrup Nutrition 0.000 claims description 3
- 239000003826 tablet Substances 0.000 claims description 3
- 239000002674 ointment Substances 0.000 claims description 2
- 239000003390 Chinese drug Substances 0.000 claims 2
- REPVLJRCJUVQFA-UHFFFAOYSA-N (-)-isopinocampheol Natural products C1C(O)C(C)C2C(C)(C)C1C2 REPVLJRCJUVQFA-UHFFFAOYSA-N 0.000 abstract 1
- 244000144619 Abrus precatorius Species 0.000 abstract 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 abstract 1
- 241000972672 Phellodendron Species 0.000 abstract 1
- 240000000528 Ricinus communis Species 0.000 abstract 1
- 235000004443 Ricinus communis Nutrition 0.000 abstract 1
- 229940116229 borneol Drugs 0.000 abstract 1
- CKDOCTFBFTVPSN-UHFFFAOYSA-N borneol Natural products C1CC2(C)C(C)CC1C2(C)C CKDOCTFBFTVPSN-UHFFFAOYSA-N 0.000 abstract 1
- 229910052802 copper Inorganic materials 0.000 abstract 1
- 239000010949 copper Substances 0.000 abstract 1
- DTGKSKDOIYIVQL-UHFFFAOYSA-N dl-isoborneol Natural products C1CC2(C)C(O)CC1C2(C)C DTGKSKDOIYIVQL-UHFFFAOYSA-N 0.000 abstract 1
- JEIPFZHSYJVQDO-UHFFFAOYSA-N iron(III) oxide Inorganic materials O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 abstract 1
- 238000000874 microwave-assisted extraction Methods 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 description 8
- 238000005516 engineering process Methods 0.000 description 4
- 239000006071 cream Substances 0.000 description 3
- 238000009472 formulation Methods 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 239000002245 particle Substances 0.000 description 3
- 206010007247 Carbuncle Diseases 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 206010017553 Furuncle Diseases 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 239000013078 crystal Substances 0.000 description 2
- 230000003211 malignant effect Effects 0.000 description 2
- 239000011858 nanopowder Substances 0.000 description 2
- 239000000825 pharmaceutical preparation Substances 0.000 description 2
- 230000000144 pharmacologic effect Effects 0.000 description 2
- 239000007962 solid dispersion Substances 0.000 description 2
- 230000008961 swelling Effects 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 229940126678 chinese medicines Drugs 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 230000002500 effect on skin Effects 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000002086 nanomaterial Substances 0.000 description 1
- 239000002547 new drug Substances 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
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- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The present invention discloses a nano Badu preparation medicine. It is made up by using 12 Chinese medicinal materials of nano prayer-beads, nano castor bean, nano borneol, nano copper rust, nano phellodendron and others as raw material through the processes of microwave extraction, reduced pressure concentration and supersonic jet spray drying. Its grain fineness is up to 1200-1500 meshes, grain size is 0.1-200 nm, in which most of grain size is less than 100 nm. Said medicine is high in biological utilization rate and obvious in therapeutic effect.
Description
The nanometer that the present invention relates to a kind of reducing swelling and alleviating pain, the putrefaction-removing granulation-promoting preparation medicine of drawing out pus by applying a plaster to the affected part the invention still further relates to the method for this medication preparation.
The patch cream of drawing out pus by applying a plaster to the affected part is a kind of classical Chinese patent medicine, mainly contains effects such as reducing swelling and alleviating pain, putrefaction-removing granulation-promoting, is used for diseases such as carbuncle, furuncle and malignant sore, nameless gall.But traditional patch cream of drawing out pus by applying a plaster to the affected part absorbs not exclusively, and bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully the nanometer of the increase evident in efficacy preparation medicine of drawing out pus by applying a plaster to the affected part.
The preparation method that another object of the present invention provides this nanometer to draw out pus by applying a plaster to the affected part preparation medicine.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
Nanometer Os Gallus domesticus 500-990 part nanometer Semen Ricini 600-1500 part nanometer Borneolum Syntheticum 100-500 part
Nanometer Aerugo 8-28 part nano phellodendron bark 150-500 part nanometer Herba Violae 60-150 part
Nanometer Herba Taraxaci 60-150 part nanometer Olibanum 60-150 part nanometer Myrrha 100-350 part
Nanometer Crinis Carbonisatus 60-150 part nanometer Ramulus Salicis Babylonicae 600-1500 part nanometer Calomelas 15-50 part
The formula optimization weight proportion scope of medicine of the present invention is:
Nanometer Os Gallus domesticus 600-900 part nanometer Semen Ricini 800-1200 part nanometer Borneolum Syntheticum 200-300 part
Nanometer Aerugo 12-18 part nano phellodendron bark 200-300 part nanometer Herba Violae 80-120 part
Nanometer Herba Taraxaci 80-120 part nanometer Olibanum 80-120 part nanometer Myrrha 150-250 part
Nanometer Crinis Carbonisatus 80-120 part nanometer Ramulus Salicis Babylonicae 800-1200 part nanometer Calomelas 20-30 part
The optimum weight proportioning of medicine of the present invention is:
250 parts of 1000 parts of nanometer Borneolum Syntheticums of 750 parts of nanometer Semen Ricini of nanometer Os Gallus domesticus
100 parts of 250 parts of nanometer Herba Violaes of 15 parts of nano phellodendron barks of nanometer Aerugo
200 parts of 100 parts of nanometer Myrrhas of 100 parts of nanometer Olibanums of nanometer Herba Taraxaci
25 parts of 1000 parts of nanometer Calomelass of 100 parts of nanometer Ramulus Salicis Babylonicaes of nanometer Crinis Carbonisatus
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material is because the special construction of nano material---the particle size of material is less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15%-50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, add to concoct according to Chinese Pharmacopoeia one one of version in 2000 and be processed into the common Chinese decoction pieces
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20-30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃-60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters-990 meter per seconds of effluxvelocity, 30 ℃ of-60 ℃ of temperature, under 0 to the 0.05MPa pressure,, promptly make the nanometer prepared slices of Chinese crude drugs with the instantaneous drying of hypersonic velocity.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20-30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃-60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters-990 meter per seconds of effluxvelocity, 30 ℃ of-60 ℃ of temperature, under 0 to the 0.05MPa pressure, with the instantaneous drying of hypersonic velocity jet, the preparation nano powder of must drawing out pus by applying a plaster to the affected part;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
It is identical that above-mentioned two kinds of methods are made the draw out pus by applying a plaster to the affected part pharmacological effect of preparation medicine of nanometer.
A kind of important feature of the present invention is: the made drug material of the present invention has reached nanoscale, the common patch paste formulation material of drawing out pus by applying a plaster to the affected part is micron or the above particle diameter of millimeter, can only cross the 80-120 mesh sieve, the drug material that the present invention is made, particle diameter is at 0.1-200nm, the overwhelming majority can be crossed the 1200-1500 mesh sieve less than 100nm.
Another important feature of the present invention is: solid preparation of the present invention disintegrate rapidly, and solid dispersion is good in water, absorb fully, the bioavailability height, the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also created the nanometer new drug formulation that the pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, medicated wine, syrup, oral solution etc. of preparation medicine have no precedent in the past of drawing out pus by applying a plaster to the affected part.
Pharmaceutical preparation of the present invention can be used for treatment of conditions such as carbuncle, furuncle and malignant sore, nameless gall, and clinical efficacy significantly is better than traditional patch cream of drawing out pus by applying a plaster to the affected part.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment:
Prepare nano raw material by preceding method:
250 parts of 1000 parts of nanometer Borneolum Syntheticums of 750 parts of nanometer Semen Ricini of nanometer Os Gallus domesticus
100 parts of 250 parts of nanometer Herba Violaes of 15 parts of nano phellodendron barks of nanometer Aerugo
200 parts of 100 parts of nanometer Myrrhas of 100 parts of nanometer Olibanums of nanometer Herba Taraxaci
25 parts of 1000 parts of nanometer Calomelass of 100 parts of nanometer Ramulus Salicis Babylonicaes of nanometer Crinis Carbonisatus
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent membrane standard, filmogen adopts polyvinyl alcohol, make the nanometer membrane of drawing out pus by applying a plaster to the affected part, every membrane area size is the 2-100 square centimeter, and content of dispersion is the 1-50 gram, every medicine film pasted 1-7 days, pasted the medicine position: the affected part.
Claims (6)
1, a kind of nanometer preparation medicine of drawing out pus by applying a plaster to the affected part is characterized in that it is the medicament that the nano raw material of following weight proportioning is made:
Nanometer Os Gallus domesticus 500-990 part nanometer Semen Ricini 600-1500 part nanometer Borneolum Syntheticum 100-500 part
Nanometer Aerugo 8-28 part nano phellodendron bark 150-500 part nanometer Herba Violae 60-150 part
Nanometer Herba Taraxaci 60-150 part nanometer Olibanum 60-150 part nanometer Myrrha 100-350 part
Nanometer Crinis Carbonisatus 60-150 part nanometer Ramulus Salicis Babylonicae 600-1500 part nanometer Calomelas 15-50 part
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1--10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3--72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
2, the nanometer according to claim 1 preparation medicine of drawing out pus by applying a plaster to the affected part, wherein the weight proportion of each nano raw material is:
Nanometer Os Gallus domesticus 600-900 part nanometer Semen Ricini 800-1200 part nanometer Borneolum Syntheticum 200-300 part
Nanometer Aerugo 12-18 part nano phellodendron bark 200-300 part nanometer Herba Violae 80-120 part
Nanometer Herba Taraxaci 80-120 part nanometer Olibanum 80-120 part nanometer Myrrha 150-250 part
Nanometer Crinis Carbonisatus 80-120 part nanometer Ramulus Salicis Babylonicae 800-1200 part nanometer Calomelas 20-30 part
3, the nanometer according to claim 1 preparation medicine of drawing out pus by applying a plaster to the affected part, wherein the weight proportion of each nano raw material is:
250 parts of 1000 parts of nanometer Borneolum Syntheticums of 750 parts of nanometer Semen Ricini of nanometer Os Gallus domesticus
100 parts of 250 parts of nanometer Herba Violaes of 15 parts of nano phellodendron barks of nanometer Aerugo
200 parts of 100 parts of nanometer Myrrhas of 100 parts of nanometer Olibanums of nanometer Herba Taraxaci
25 parts of 1000 parts of nanometer Calomelass of 100 parts of nanometer Ramulus Salicis Babylonicaes of nanometer Crinis Carbonisatus
4, according to claim 1 or the 2 or 3 described nanometers preparation medicine of drawing out pus by applying a plaster to the affected part, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
5, according to the draw out pus by applying a plaster to the affected part pharmaceutical methods of preparation medicine of claim 1 or 2 or 3 described nanometers, it is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1--10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3--72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
6, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100184 CN1362131A (en) | 2001-01-04 | 2001-01-04 | Nano pus drawing out medicine and its preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100184 CN1362131A (en) | 2001-01-04 | 2001-01-04 | Nano pus drawing out medicine and its preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1362131A true CN1362131A (en) | 2002-08-07 |
Family
ID=4651364
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 01100184 Pending CN1362131A (en) | 2001-01-04 | 2001-01-04 | Nano pus drawing out medicine and its preparation |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1362131A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105535596A (en) * | 2015-12-29 | 2016-05-04 | 平南县莹冠仙生物农业科技有限公司 | Traditional Chinese medicine composition for treating carbuncle-abscess and furunculosis and preparation method thereof |
-
2001
- 2001-01-04 CN CN 01100184 patent/CN1362131A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105535596A (en) * | 2015-12-29 | 2016-05-04 | 平南县莹冠仙生物农业科技有限公司 | Traditional Chinese medicine composition for treating carbuncle-abscess and furunculosis and preparation method thereof |
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